AutismKB 2.0

Annotation Detail for GCOM1


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Basic Information Top
Gene Symbol:GCOM1 ( FLJ30973,GRINL1A,Gcom2,Gup,Gup1,Gup2,MGC126694,MGC138353,MYOZAP )
Gene Full Name: GRINL1A complex locus
Band: 15q21.3
Quick LinksEntrez ID:145781; OMIM: NA; Uniprot ID:GCOM1_HUMAN; ENSEMBL ID: ENSG00000137878; HGNC ID: 26424
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D006830 Hydralazine [Hydralazine co-treated with Valproic Acid] results in increased expression of GCOM1 mRNAaffects cotreatment|increases expression 17183730
D010634 Phenobarbital NR1I3 protein affects the reaction [Phenobarbital results in increased expression of GCOM1 mRNA]affects reaction|increases expression 19482888
D010634 Phenobarbital Phenobarbital results in increased expression of GCOM1 mRNAincreases expression 19482888
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of GCOM1 mRNAaffects binding|increases activity|increases expression 19710929
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of GCOM1 mRNAincreases expression 20106945
D014635 Valproic Acid [Hydralazine co-treated with Valproic Acid] results in increased expression of GCOM1 mRNAaffects cotreatment|increases expression 17183730
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 17.616195326
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 17.6115322242 11752688 14514962
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 17.618875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 4.3019490988
MESH:D055371 Acute Lung Injury pirinixic acid 3.5218653653
MESH:D018248 Adenoma, Liver Cell Phenobarbital 20.7117620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 20.7116434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 20.7116835633
MESH:D000550 Amblyopia Valproic Acid 5.8517688650
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.2911748828
MESH:D001008 Anxiety Disorders Valproic Acid 3.8617497229
MESH:D001321 Autistic Disorder Valproic Acid 1.9815238991 18558336 18177632 17507914 16609825 20603192 18775368 17688650 17157402 18316065 18940202 18985861 19460635 18396377 19232924
MESH:D001714 Bipolar Disorder Valproic Acid 3.2320046352 17594078
MESH:D001778 Blood Coagulation Disorders pirinixic acid 10.0419483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 10.0412125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.4015340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 8.7215746008
MESH:D001848 Bone Diseases, Developmental Valproic Acid 8.728888407
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.6720435547
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 3.0916835633
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 1.9417173139 20007298 20935162 1701930 6705139
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.5418670907 16120746 18850075
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.744080065
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.8120734317
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.4916835633
MESH:D002779 Cholestasis pirinixic acid 3.0819176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.2216354765 15340226 15668235 8697196 12621046
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.3814669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.5510048152 15322242 20055451
MESH:D019465 Craniofacial Abnormalities Valproic Acid 2.5517688650 8888407 16575769
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5618249437
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7317107852
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 4.0520420201
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 4.051733752 19641884
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 3.0211462148
MESH:D004421 Dystonia Phenobarbital 11.811851702
MESH:D004421 Dystonia Valproic Acid 11.811851702
MESH:D004487 Edema pirinixic acid 7.7912083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 7.7911000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.5116714409 15322242 18230668
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.379294722 10568697
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 12.463659116
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 12.4617275665 3659116
MESH:D004828 Epilepsies, Partial Phenobarbital 12.103922381 11558140
MESH:D004828 Epilepsies, Partial Valproic Acid 12.103922381 16628512
MESH:D004827 Epilepsy Phenobarbital 7.1920417680
MESH:D004827 Epilepsy Valproic Acid 7.1918234410 20417680
MESH:D004832 Epilepsy, Absence Phenobarbital 9.966401628
MESH:D004832 Epilepsy, Absence Valproic Acid 9.966254150 7562514 6426943
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 12.977750514
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 12.977750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 12.353659116
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 12.353659116
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.2711564622
MESH:D005234 Fatty Liver pirinixic acid 8.9920131406 19236843
MESH:D005234 Fatty Liver Valproic Acid 8.9914986274 19224547
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.9411858732
MESH:D005315 Fetal Diseases Valproic Acid 5.5016575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 4.5718558336 8888407
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 3.4320067830
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 5.2110696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.4910048152 11294989
MESH:D006333 Heart Failure pirinixic acid 2.7320558911
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.7111000095
MESH:D006529 Hepatomegaly Phenobarbital 17.4016109766
MESH:D006529 Hepatomegaly pirinixic acid 17.4018467677 19176532 19772884 16221962
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 17.4016120746 12621046 15340226
MESH:D006849 Hydrocephalus Valproic Acid 5.4117688650
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.668697196 16959395 15340226 16354765 18606429
MESH:D006943 Hyperglycemia pirinixic acid 3.5320558911
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 2.0118670907 18850075
MESH:D046110 Hypertension, Pregnancy-Induced Hydralazine 5.1116612254
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 2.0112200463 12878042
MESH:D007333 Insulin Resistance pirinixic acid 2.8516306350
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.7116580747
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 2.1916294345 17596541
MESH:D008103 Liver Cirrhosis Phenobarbital 3.0721047994
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 2.2215474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.2212878042
MESH:D008107 Liver Diseases Phenobarbital 2.2319363144
MESH:D008113 Liver Neoplasms Phenobarbital 8.0019812893 19073162 8742319 21047994 19482888 15975961
MESH:D008113 Liver Neoplasms pirinixic acid 8.0020007298 16377806 15890375
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 8.0016984957
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 6.4817172636 6150874 1399818 18308698 2563599
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 6.4812151625
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 4.8717228818
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 1.2419555203 11884234
MESH:D008881 Migraine Disorders Valproic Acid 3.4418803445 18765137
MESH:D009135 Muscular Diseases pirinixic acid 3.9916239165
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 4.408888407
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 3.3317596541
MESH:D009203 Myocardial Infarction pirinixic acid 2.2619151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.3112213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.2216411023
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 5.0217484760
MESH:D009369 Neoplasms pirinixic acid 2.0917405874
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.6514600291
MESH:D009436 Neural Tube Defects Valproic Acid 3.3416359493 8888407
MESH:D009765 Obesity pirinixic acid 1.8820558911
MESH:D010018 Osteomalacia Phenobarbital 4.9017016548
MESH:D010190 Pancreatic Neoplasms Phenobarbital 2.5916965848
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.8612520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 4.0018163543
MESH:D011230 Precancerous Conditions Phenobarbital 3.952563599
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 11.3311399792 11118676 11222880 11896295
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 11.3320603192
MESH:D019310 Pseudolymphoma Phenobarbital 14.3212752131
MESH:D019310 Pseudolymphoma Valproic Acid 14.3211422049 12752131
MESH:D015427 Reperfusion Injury pirinixic acid 2.5319058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.2818990726
MESH:D012208 Rhabdomyosarcoma Valproic Acid 4.5819155313
MESH:D012559 Schizophrenia Valproic Acid 2.1019110320 15737665
MESH:D012640 Seizures Phenobarbital 6.783137016 11442880 4039156 16876388
MESH:D012640 Seizures Valproic Acid 6.7814763951 11738929 3137016 16876388 11044598 17978042 1511512 15475178
MESH:D003294 Seizures, Febrile Phenobarbital 5.366407741
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.1816192470
MESH:D016135 Spinal Dysraphism Valproic Acid 4.0619490988
MESH:D013226 Status Epilepticus Valproic Acid 5.1512833885
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.5112697716
MESH:D013964 Thyroid Neoplasms Phenobarbital 3.321399818
MESH:D014178 Translocation, Genetic Valproic Acid 5.8517262798
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 5.063119515
MESH:D014564 Urogenital Abnormalities Valproic Acid 5.138888407
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 5.2112125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.8615886252
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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