Annotation Detail for HAPLN3
Basic Information Top
| Gene Symbol: | HAPLN3 ( EXLD1,HsT19883 ) |
|---|---|
| Gene Full Name: | hyaluronan and proteoglycan link protein 3 |
| Band: | 15q26.1 |
| Quick Links | Entrez ID:145864; OMIM: NA; Uniprot ID:HPLN3_HUMAN; ENSEMBL ID: ENSG00000140511; HGNC ID: 21446 |
| Relate to Another Database: | SFARIGene; denovo-db |
Related Pathway Information| Chemical ID | Chemical Name | Interaction | Interaction Action | Publication |
|---|---|---|---|---|
| D000082 | Acetaminophen | Acetaminophen affects the expression of HAPLN3 mRNA | affects expression | 17562736 |
| D004054 | Diethylstilbestrol | Diethylstilbestrol results in decreased expression of HAPLN3 mRNA | decreases expression | 19371625 |
| D015025 | Zearalenone | Zearalenone results in decreased expression of HAPLN3 mRNA | decreases expression | 19371625 |
| C016340 | o,p'-DDT | o,p'-DDT results in decreased expression of HAPLN3 mRNA | decreases expression | 19371625 |
| C006253 | pirinixic acid | [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of HAPLN3 mRNA | affects binding|decreases expression|increases activity | 19710929 |
| Disease ID | Disease Name | Direct Evidence | Inference Chemical Name | Inference Score | Publication |
|---|---|---|---|---|---|
| MESH:D055371 | Acute Lung Injury | pirinixic acid | 3.52 | 18653653 | |
| MESH:D018248 | Adenoma, Liver Cell | pirinixic acid | 4.02 | 16434500 | |
| MESH:D000686 | Amyloidosis | Diethylstilbestrol | 4.92 | 15469931 | |
| MESH:D000799 | Angioedema | Acetaminophen | 4.45 | 10982225 | |
| MESH:D001321 | Autistic Disorder | Acetaminophen | 1.40 | 18445737 | |
| MESH:D001778 | Blood Coagulation Disorders | pirinixic acid | 3.52 | 19483382 | |
| MESH:D001943 | Breast Neoplasms | Diethylstilbestrol | 2.59 | 17129689 15324884 | |
| MESH:D006528 | Carcinoma, Hepatocellular | Acetaminophen | 3.13 | 3084413 | |
| MESH:D006528 | Carcinoma, Hepatocellular | Diethylstilbestrol | 3.13 | 16924424 15948411 | |
| MESH:D002386 | Cataract | Acetaminophen | 2.77 | 10977129 | |
| MESH:D002779 | Cholestasis | pirinixic acid | 3.08 | 19176532 | |
| MESH:D003456 | Cryptorchidism | Diethylstilbestrol | 5.00 | 16002989 12952375 | |
| MESH:D003876 | Dermatitis, Atopic | pirinixic acid | 2.56 | 18249437 | |
| MESH:D056486 | Drug-Induced Liver Injury | Acetaminophen | 1.66 | 19923254 11461765 11739529 16227642 17562736 14725611 12540782 11421492 14550746 19416960 19420014 17906064 18713872 16109766 19370779 18071297 16393943 16177239 19164858 10915739 12594235 12958197 16485898 12705907 11529661 19739265 10774834 16081117 15619225 19085960 11743745 11287661 2444490 17522070 12392966 15968718 10663392 11834606 12153990 16781746 14986274 | |
| MESH:D056487 | Drug-Induced Liver Injury, Chronic | Acetaminophen | 4.71 | 19426721 | |
| MESH:D004487 | Edema | pirinixic acid | 2.85 | 12083418 | |
| MESH:D004714 | Endometrial Hyperplasia | Diethylstilbestrol | 5.23 | 16402032 | |
| MESH:D016889 | Endometrial Neoplasms | Diethylstilbestrol | 3.68 | 15700306 16804899 | |
| MESH:D005234 | Fatty Liver | pirinixic acid | 3.14 | 19236843 20131406 | |
| MESH:D052776 | Female Urogenital Diseases | Diethylstilbestrol | 3.85 | 16611131 15751030 16513791 16534752 16002989 | |
| MESH:D005756 | Gastritis | Acetaminophen | 4.29 | 16983495 | |
| MESH:D005833 | Genital Neoplasms, Female | Diethylstilbestrol | 5.49 | 16452187 | |
| MESH:D006333 | Heart Failure | pirinixic acid | 2.73 | 20558911 | |
| MESH:D006529 | Hepatomegaly | pirinixic acid | 3.48 | 18467677 16221962 19772884 19176532 | |
| MESH:D006930 | Hyperalgesia | Acetaminophen | 2.99 | 16870215 | |
| MESH:D006943 | Hyperglycemia | pirinixic acid | 3.53 | 20558911 | |
| MESH:D006965 | Hyperplasia | Diethylstilbestrol | 4.92 | 14722030 12960047 | |
| MESH:D007021 | Hypospadias | Diethylstilbestrol | 5.06 | 16002989 | |
| MESH:D007246 | Infertility | Diethylstilbestrol | 4.79 | 15036965 | |
| MESH:D007333 | Insulin Resistance | pirinixic acid | 2.85 | 16306350 | |
| MESH:D007674 | Kidney Diseases | Acetaminophen | 2.38 | 15629191 12587719 | |
| MESH:D007680 | Kidney Neoplasms | Diethylstilbestrol | 3.76 | 14681315 15003126 16762066 | |
| MESH:D007859 | Learning Disorders | Diethylstilbestrol | 4.54 | 17184923 | |
| MESH:D008106 | Liver Cirrhosis, Experimental | pirinixic acid | 1.35 | 15474484 | |
| MESH:D008107 | Liver Diseases | Acetaminophen | 1.69 | 16610002 19784758 16611625 19460945 12587719 19014921 11587558 12969438 | |
| MESH:D017114 | Liver Failure, Acute | Acetaminophen | 3.58 | 16871587 17185352 | |
| MESH:D008113 | Liver Neoplasms | Diethylstilbestrol | 4.95 | 16712894 15890375 | |
| MESH:D008113 | Liver Neoplasms | pirinixic acid | 4.95 | 20007298 16377806 15890375 | |
| MESH:D008181 | Lupus Nephritis | Diethylstilbestrol | 5.69 | 15166399 | |
| MESH:D008223 | Lymphoma | Diethylstilbestrol | 3.72 | 15700306 | |
| MESH:D052801 | Male Urogenital Diseases | Diethylstilbestrol | 6.13 | 16002989 | |
| MESH:D008546 | Melanoma, Experimental | Acetaminophen | 4.05 | 19513568 | |
| MESH:D009135 | Muscular Diseases | pirinixic acid | 3.99 | 16239165 | |
| MESH:D009203 | Myocardial Infarction | pirinixic acid | 2.26 | 19151258 | |
| MESH:D015428 | Myocardial Reperfusion Injury | pirinixic acid | 3.22 | 16411023 | |
| MESH:D009369 | Neoplasms | Diethylstilbestrol | 5.55 | 15313581 | |
| MESH:D009369 | Neoplasms | pirinixic acid | 5.55 | 17405874 | |
| MESH:D009421 | Nervous System Malformations | Diethylstilbestrol | 4.57 | 11399458 | |
| MESH:D019636 | Neurodegenerative Diseases | Acetaminophen | 3.18 | 18514411 | |
| MESH:D009765 | Obesity | pirinixic acid | 1.88 | 20558911 | |
| MESH:D010146 | Pain | Acetaminophen | 2.69 | 16870215 | |
| MESH:D010900 | Pituitary Diseases | Diethylstilbestrol | 5.78 | 14722030 | |
| MESH:D010911 | Pituitary Neoplasms | Diethylstilbestrol | 5.16 | 15687265 16977796 | |
| MESH:D011297 | Prenatal Exposure Delayed Effects | Diethylstilbestrol | 4.65 | 17184923 | |
| MESH:D011471 | Prostatic Neoplasms | Diethylstilbestrol | 3.51 | 15046698 17136230 15846301 | |
| MESH:D015427 | Reperfusion Injury | pirinixic acid | 2.53 | 19058328 | |
| MESH:D013088 | Spermatocele | Diethylstilbestrol | 5.32 | 16002989 16709447 | |
| MESH:D001749 | Urinary Bladder Neoplasms | Diethylstilbestrol | 2.88 | 17306315 16452187 16712894 | |
| MESH:D014581 | Urticaria | Acetaminophen | 3.38 | 10982225 | |
| MESH:D002583 | Uterine Cervical Neoplasms | Diethylstilbestrol | 4.38 | 16175088 | |
| MESH:D014591 | Uterine Diseases | Diethylstilbestrol | 5.78 | 14652134 | |
| MESH:D014594 | Uterine Neoplasms | Diethylstilbestrol | 4.51 | 15809267 16690809 | |
| MESH:D014625 | Vaginal Neoplasms | Diethylstilbestrol | 4.92 | 16002989 16513791 |
| No data |