AutismKB 2.0

Annotation Detail for ADRA1D


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:ADRA1D ( ADRA1,ADRA1A,ADRA1R,ALPHA1,DAR,dJ779E11.2 )
Gene Full Name: adrenergic, alpha-1D-, receptor
Band: 20p13
Quick LinksEntrez ID:146; OMIM: 104219; Uniprot ID:ADA1D_HUMAN; ENSEMBL ID: ENSG00000171873; HGNC ID: 280
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04270Vascular smooth muscle contraction
hsa04080Neuroactive ligand-receptor interaction
hsa04020Calcium signaling pathway
hsa04970Salivary secretion
Pathway IDPathway Name
Signaling by GPCR
No data
Pathway IDPathway Name
P00026Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
P00002Alpha adrenergic receptor signaling pathway
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1902Kidney failure
Desease Name
PHARMACOGENOMIC
interstitial cystitis
INFECTION
left ventricular fractional shortening
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C099060 1-(2-(3-methoxyphenyl)ethyl)phenoxy-3-(dimethylamino)-2-propanol 1-(2-(3-methoxyphenyl)ethyl)phenoxy-3-(dimethylamino)-2-propanol inhibits the reaction [Prazosin binds to ADRA1D protein]affects binding|decreases reaction 11937776
C057446 5-methylurapidil 5-methylurapidil binds to ADRA1D proteinaffects binding 15493479
D000643 Ammonium Chloride Ammonium Chloride affects the expression of ADRA1D mRNAaffects expression 16483693
D000661 Amphetamine ADRA1D protein affects the susceptibility to Amphetamineaffects response to substance 12874602
C053428 BMY 7378 BMY 7378 binds to and results in decreased activity of ADRA1D proteinaffects binding|decreases activity 19371927
C053428 BMY 7378 BMY 7378 inhibits the reaction [Phenylephrine binds to and results in increased activity of ADRA1D protein]affects binding|decreases reaction|increases activity 19371927
C053428 BMY 7378 BMY 7378 binds to [ADRA1A protein binds to ADRA1D protein]affects binding 16195468
C053428 BMY 7378 BMY 7378 binds to [ADRA1B protein binds to ADRA1D protein]affects binding 16195468
C053428 BMY 7378 BMY 7378 binds to ADRA1D proteinaffects binding 16195468
15493479
C053428 BMY 7378 BMY 7378 inhibits the reaction [ADRA1D protein results in increased susceptibility to Phenylephrine]decreases reaction|increases response to substance 18604236
C053428 BMY 7378 BMY 7378 binds to and results in decreased activity of ADRA1D proteinaffects binding|decreases activity 19566752
15872040
11306708
15951348
C053428 BMY 7378 BMY 7378 inhibits the reaction [ADRA1D protein results in increased susceptibility to Phenylephrine]decreases reaction|increases response to substance 19566752
C053428 BMY 7378 chlorethylclonidine inhibits the reaction [BMY 7378 results in decreased activity of ADRA1D protein]decreases activity|decreases reaction 15951348
D002065 Buspirone Buspirone binds to and results in increased activity of ADRA1D proteinaffects binding|increases activity 15872040
C055494 caffeic acid phenethyl ester [Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of ADRA1D mRNAaffects cotreatment|decreases expression 20360939
D002251 Carbon Tetrachloride Carbon Tetrachloride results in increased expression of ADRA1D mRNAincreases expression 16644059
C051731 chlorethylclonidine chlorethylclonidine inhibits the reaction [BMY 7378 results in decreased activity of ADRA1D protein]decreases activity|decreases reaction 15951348
D004390 Chlorpyrifos Chlorpyrifos affects the expression of ADRA1D mRNAaffects expression 18812211
D004390 Chlorpyrifos Chlorpyrifos results in decreased expression of ADRA1D mRNAdecreases expression 17452286
C014347 decitabine decitabine affects the methylation of ADRA1D promoteraffects methylation 17384146
C014347 decitabine [decitabine affects the methylation of ADRA1D promoter] which affects the expression of ADRA1D mRNAaffects expression|affects methylation 17384146
C014347 decitabine decitabine results in increased expression of ADRA1D proteinincreases expression 17384146
D003907 Dexamethasone Dexamethasone results in increased expression of ADRA1D mRNAincreases expression 10229127
D003907 Dexamethasone Dexamethasone results in increased expression of ADRA1D proteinincreases expression 10229127
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of ADRA1D mRNAaffects cotreatment|decreases expression 20360939
D004958 Estradiol Estradiol results in decreased expression of ADRA1D mRNAdecreases expression 15849065
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of ADRA1D mRNAincreases expression 17557909
17351261
15834898
D005419 Flavonoids Flavonoids results in decreased expression of ADRA1D mRNAdecreases expression 18035473
D007650 Ketanserin Ketanserin inhibits the reaction [Prazosin binds to ADRA1D protein]affects binding|decreases reaction 11937776
D008729 Methoxamine Methoxamine binds to ADRA1D proteinaffects binding 15493479
C064357 naftopidil naftopidil binds to and results in decreased activity of ADRA1D proteinaffects binding|decreases activity 19371927
C064357 naftopidil naftopidil inhibits the reaction [Phenylephrine binds to and results in increased activity of ADRA1D protein]affects binding|decreases reaction|increases activity 19371927
D009638 Norepinephrine Norepinephrine binds to ADRA1D proteinaffects binding 15493479
D009638 Norepinephrine ADRA1D affects the susceptibility to Norepinephrineaffects response to substance 11901185
D010109 Oxymetazoline Oxymetazoline binds to ADRA1D proteinaffects binding 15493479
D010269 Paraquat Paraquat results in decreased expression of ADRA1D mRNAdecreases expression 17077588
D010646 Phentolamine Phentolamine binds to ADRA1D proteinaffects binding 15493479
D010656 Phenylephrine BMY 7378 inhibits the reaction [Phenylephrine binds to and results in increased activity of ADRA1D protein]affects binding|decreases reaction|increases activity 19371927
D010656 Phenylephrine naftopidil inhibits the reaction [Phenylephrine binds to and results in increased activity of ADRA1D protein]affects binding|decreases reaction|increases activity 19371927
D010656 Phenylephrine Phenylephrine binds to and results in increased activity of ADRA1D proteinaffects binding|increases activity 19371927
D010656 Phenylephrine ADRA1D protein affects the susceptibility to Phenylephrineaffects response to substance 18257748
D010656 Phenylephrine Phenylephrine binds to ADRA1D proteinaffects binding 15493479
D010656 Phenylephrine ADRA1D protein results in increased susceptibility to Phenylephrineincreases response to substance 18604236
D010656 Phenylephrine BMY 7378 inhibits the reaction [ADRA1D protein results in increased susceptibility to Phenylephrine]decreases reaction|increases response to substance 18604236
D010656 Phenylephrine ADRA1D affects the susceptibility to Phenylephrineaffects response to substance 11901185
D010656 Phenylephrine Phenylephrine results in increased expression of ADRA1D mRNAincreases expression 17122163
D010656 Phenylephrine ADRA1D protein results in increased susceptibility to Phenylephrineincreases response to substance 19566752
D010656 Phenylephrine BMY 7378 inhibits the reaction [ADRA1D protein results in increased susceptibility to Phenylephrine]decreases reaction|increases response to substance 19566752
D010656 Phenylephrine Phenylephrine binds to and results in increased activity of ADRA1D proteinaffects binding|increases activity 16371063
D010656 Phenylephrine Phenylephrine results in increased activity of ADRA1D proteinincreases activity 19376108
C025299 polyphenols polyphenols results in decreased expression of ADRA1D mRNAdecreases expression 16293270
D011224 Prazosin 1-(2-(3-methoxyphenyl)ethyl)phenoxy-3-(dimethylamino)-2-propanol inhibits the reaction [Prazosin binds to ADRA1D protein]affects binding|decreases reaction 11937776
D011224 Prazosin Ketanserin inhibits the reaction [Prazosin binds to ADRA1D protein]affects binding|decreases reaction 11937776
D011224 Prazosin Prazosin binds to ADRA1D proteinaffects binding 15493479
D011224 Prazosin sarpogrelate inhibits the reaction [Prazosin binds to ADRA1D protein]affects binding|decreases reaction 11937776
D012110 Reserpine ADRA1D protein results in increased susceptibility to Reserpineincreases response to substance 15159276
D012110 Reserpine Reserpine results in increased expression of ADRA1D mRNAincreases expression 15159276
17676312
C099495 RS 17053 RS 17053 binds to ADRA1D proteinaffects binding 15493479
C064294 sarpogrelate sarpogrelate inhibits the reaction [Prazosin binds to ADRA1D protein]affects binding|decreases reaction 11937776
D013311 Streptozocin Streptozocin results in decreased expression of ADRA1D mRNAdecreases expression 19298542
D013726 Terbutaline Terbutaline results in increased expression of ADRA1D mRNAincreases expression 10229127
D013726 Terbutaline Terbutaline results in increased expression of ADRA1D proteinincreases expression 10229127
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of ADRA1D mRNAincreases expression 20106945
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Terbutaline 7.8114610225
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 7.8115322242 11752688 14514962
MESH:D000138 Acidosis Ammonium Chloride 3.2518287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.6317505938
MESH:D000230 Adenocarcinoma Estradiol 3.9411473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 3.9414692618
MESH:D000236 Adenoma Diethylnitrosamine 2.6710737359 6695378
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 9.0219052882 19061943 18056438 16434500 17162532 17620307
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 9.0216835633
MESH:D000382 Agricultural Workers' Diseases Chlorpyrifos 7.9316611668 11874814 17119214
MESH:D000382 Agricultural Workers' Diseases Paraquat 7.9311874814
MESH:D019969 Amphetamine-Related Disorders Amphetamine 5.7418475255 16916582 15010207 16459022
MESH:D000686 Amyloidosis Terbutaline 5.337986221
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.6811748828
MESH:D000855 Anorexia Amphetamine 4.7412005258 16084549 12183048 16101753
MESH:D001145 Arrhythmias, Cardiac Phenylephrine 3.8517460149
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 9.6211256880
MESH:D001161 Arteriosclerosis Reserpine 9.6210729376
MESH:D001169 Arthritis, Experimental Dexamethasone 6.7417659584
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 6.7415885639
MESH:D001321 Autistic Disorder Buspirone 2.8518056831
MESH:D001321 Autistic Disorder Norepinephrine 2.858570775
MESH:D001321 Autistic Disorder Terbutaline 2.8517400887 16417856
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 2.7712125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.4715340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.5715746008
MESH:D001919 Bradycardia Phenylephrine 4.2315306635
MESH:D001943 Breast Neoplasms decitabine 2.2619208741 18320071
MESH:D001943 Breast Neoplasms Diethylnitrosamine 2.2617474063
MESH:D001943 Breast Neoplasms Estradiol 2.2619861407 16675129 14630087 12948864 17289903 17261762 18497071 17018787
MESH:D001943 Breast Neoplasms Reserpine 2.2611921183
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.2620435547
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.1516111702
MESH:D019559 Capillary Leak Syndrome Terbutaline 5.549428835 11713377
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.4816192424 16097048 16050911 15721981 16011737 15700767 16124888 10355542 18705752 15673190 3786805 16227642
MESH:D002276 Carcinoid Tumor Streptozocin 5.2916051944
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.5616835633
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 4.2718788625
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 4.2710737359 18506893 18971187 18788625 18494052 19701751 20512989 19919837 16830150 16878318 19208518 17173139 16935385 16288022 16569478 10672840 20727157 19171122 16681979 17138121 19418558 17761372 16540662 20514400 16502159 17978847 18665156 17055752 20007298 17428255 18056438 18210153 16328049 3581430 20524982 19394651 19107877 19539802 17162532 3084413 16698587 19052882 20214788 19519916 20101231 16779866 19383236 18393292 18691550 20935162 18978308 11831363 20432363 19335982 16807293 21159647 18785209 20084675 19822196
MESH:D006528 Carcinoma, Hepatocellular Estradiol 4.2716924424
MESH:D002294 Carcinoma, Squamous Cell decitabine 2.5019215824
MESH:D006332 Cardiomegaly Norepinephrine 10.6111179087
MESH:D006332 Cardiomegaly Phenylephrine 10.6117124262 15728586 17287366 11754973 16170337 11179087
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 10.6118670907 18850075 16120746
MESH:D002375 Catalepsy Norepinephrine 5.238216760
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 5.992727394 7505956 21159647 17174075
MESH:D002471 Cell Transformation, Neoplastic Estradiol 5.9918566989
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 8.4619052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 8.4616835633
MESH:D002779 Cholestasis Ethinyl Estradiol 2.6517110522 17333356 15861022 16919318 11677210 16105132 17681005
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 1.9716354765 8697196 15668235 15340226 12621046
MESH:D003110 Colonic Neoplasms decitabine 5.5917616700
MESH:D003110 Colonic Neoplasms Dexamethasone 5.5915824018
MESH:D003110 Colonic Neoplasms polyphenols 5.5916293270
MESH:D015179 Colorectal Neoplasms decitabine 2.1018981723
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.8017141729 14669216
MESH:D003371 Cough Terbutaline 5.2519679606
MESH:D019465 Craniofacial Abnormalities Dexamethasone 2.5117728286
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.5115322242 20055451 10048152
MESH:D017449 Dermatitis, Allergic Contact Dexamethasone 3.1212438553
MESH:D003920 Diabetes Mellitus Streptozocin 4.4716285004
MESH:D003921 Diabetes Mellitus, Experimental Streptozocin 4.232177838 17442507 12446591 19298542 18603373 16684804 15862027 7637645 11055810 19960420 19496084 6379147 16286809 12644472 18715473 12083368 17874149 8740154 15831366 19586609 12093613 15298345 11260395 1374869
MESH:D003922 Diabetes Mellitus, Type 1 Streptozocin 3.5418603373
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 6.7420387270
MESH:D003924 Diabetes Mellitus, Type 2 Streptozocin 6.7419586609 19647726
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 6.7417107852
MESH:D058065 Diabetic Cardiomyopathies Streptozocin 5.4116025228
MESH:D003928 Diabetic Nephropathies Estradiol 8.4219279558
MESH:D003928 Diabetic Nephropathies Streptozocin 8.4219682444 19960420
MESH:D003930 Diabetic Retinopathy Streptozocin 5.1317662242
MESH:D003967 Diarrhea Dexamethasone 3.417237001
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 11.0017522070 19336974 9327722 6884620 19085960 15027814 16227642 10092053 6623471 11566570 16177239 10915739 7440962 2869522 4309450 7179309 15998439 21278145 15968718 7120509 3732212 3786805
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 11.0019107877
MESH:D056486 Drug-Induced Liver Injury polyphenols 11.0019370779
MESH:D056486 Drug-Induced Liver Injury Prazosin 11.0018071297
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 11.0020420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.5311462148
MESH:D004485 Eczema Dexamethasone 4.1612438553
MESH:D004487 Edema Dexamethasone 5.9719703484
MESH:D004487 Edema Tetrachlorodibenzodioxin 5.9711000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.5918230668 15322242 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 2.9012538720
MESH:D004701 Endocrine Gland Neoplasms decitabine 4.8019294695
MESH:D016889 Endometrial Neoplasms Estradiol 2.7811473722 18566989 19148513
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.769294722 10568697
MESH:D004827 Epilepsy Norepinephrine 4.14821787
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 4.8016302075
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.7811564622
MESH:D005221 Fatigue Amphetamine 5.2919890266
MESH:D005234 Fatty Liver Carbon Tetrachloride 11.5019224547 15959796 16239168 12795759 61145 16045604 17595544 12631006
MESH:D005234 Fatty Liver Diethylnitrosamine 11.5020387270 21071580
MESH:D005234 Fatty Liver Ethinyl Estradiol 11.5015345470
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.1511858732
MESH:D005355 Fibrosis Carbon Tetrachloride 13.2018705752
MESH:D005355 Fibrosis Terbutaline 13.2015467267
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 13.2020067830
MESH:D005911 Gliosis Paraquat 4.8511124998
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.2810696789
MESH:D006258 Head and Neck Neoplasms decitabine 3.2819215824
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.1711294989 10048152
MESH:D006331 Heart Diseases Streptozocin 4.0612093613
MESH:D018883 Heat Stroke Ketanserin 6.8616205318
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.0611000095
MESH:D006505 Hepatitis Carbon Tetrachloride 3.3019110552 19900420
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 2.5912621046 15340226 16120746
MESH:D006548 Hernia, Diaphragmatic Dexamethasone 2.967520565
MESH:D006558 Herpes Genitalis Estradiol 4.7215709030
MESH:D019584 Hot Flashes Estradiol 3.4417088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.7316959395 18606429 16354765 15340226 8697196
MESH:D006930 Hyperalgesia Prazosin 4.6312727271
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.2216899240
MESH:D006948 Hyperkinesis Amphetamine 5.1214960337 1977408
MESH:D006973 Hypertension Dexamethasone 8.0117042910
MESH:D006973 Hypertension Phenylephrine 8.0112717712 8949925
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 8.0118670907 18850075
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 3.7815338365
MESH:D006984 Hypertrophy Phenylephrine 4.2818502941 12791704
MESH:D006985 Hyperventilation Terbutaline 5.7710895896
MESH:D007008 Hypokalemia Terbutaline 5.7817292646
MESH:D007021 Hypospadias Ethinyl Estradiol 3.5116569931 16945680
MESH:D007022 Hypotension Norepinephrine 4.716740701
MESH:D007035 Hypothermia Reserpine 5.971977408
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.1812013081
MESH:D007248 Infertility, Male decitabine 10.0717581917
MESH:D007248 Infertility, Male Ethinyl Estradiol 10.0717937319
MESH:D007248 Infertility, Male Paraquat 10.074850670
MESH:D007249 Inflammation Dexamethasone 14.1311099482 8960868
MESH:D007249 Inflammation Diethylnitrosamine 14.1318785209
MESH:D007249 Inflammation Flavonoids 14.1317296493
MESH:D007249 Inflammation polyphenols 14.1316366677
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 14.1312200463 12878042
MESH:D007333 Insulin Resistance Estradiol 2.7716627594 16393666
MESH:D007414 Intestinal Neoplasms caffeic acid phenethyl ester 4.3210783313
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.0616580747
MESH:D007674 Kidney Diseases caffeic acid phenethyl ester 9.3215369732
MESH:D007674 Kidney Diseases Estradiol 9.3215618244
MESH:D007674 Kidney Diseases Streptozocin 9.3212093613
MESH:D007680 Kidney Neoplasms Estradiol 2.7315610895
MESH:D053609 Lethargy Terbutaline 6.0010895896
MESH:D007938 Leukemia decitabine 2.9219235587 18980019
MESH:D007951 Leukemia, Myeloid decitabine 3.7319117987 18454857 17236224
MESH:D015470 Leukemia, Myeloid, Acute decitabine 2.3319010910 17679729 18460780 18704418 19387464 18206229
MESH:D015477 Leukemia, Myelomonocytic, Chronic decitabine 5.1518055864
MESH:D015473 Leukemia, Promyelocytic, Acute caffeic acid phenethyl ester 3.7916766008
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 6.0421278145 11903743 17157831 16239168 17334410 16943688 17174718 11408273 16221502
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 6.0418407596 18665156 19638242 20032147 18522880
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 4.6218339082 15893842 13678700 18481824 18376398 14716496 17525996 18317297 17631135 15057751 16192424 18472332 12741479 17565644 18418968 20821823 17766677 18263696 10355542 17944888 12667390 14748882 18251166 18277467 15362042 12666154 18279442 16116963 16097048 18166357 17640975 14716833 12445421 17823541 15818738 17976157 16027843 12609069 17708605 11481614 18205269 15650968 15876570 16015684 17761835 18395095 17721639 14724832 18187930 16011737 12586293 18420326 16033810 15959796 17900296 18705752 15996030 17698563 18429990 12898905 18156304 12632514 12632512 17805973 15123356 12389079 17714472 17922224 12958196 18412020 15052691 15338365 14620537 18006644 16638106 16248980 15925388 18210741 18472094 18395914 12649538 15931870 15730626 12445418 17869086 15370692 14512876 12546737 17481882 15673190 16136751 18054572 17557913
MESH:D008106 Liver Cirrhosis, Experimental Dexamethasone 4.6216718785
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 4.6214716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 4.6212878042
MESH:D008107 Liver Diseases Carbon Tetrachloride 8.7417285989 16964402 15720792 16246199 15830285
MESH:D008107 Liver Diseases Chlorpyrifos 8.7415991261
MESH:D008107 Liver Diseases Diethylnitrosamine 8.7417034775
MESH:D008107 Liver Diseases polyphenols 8.7416698588
MESH:D017093 Liver Failure Carbon Tetrachloride 3.8615123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 3.4216899240 14706259
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 6.6819294768
MESH:D008113 Liver Neoplasms Diethylnitrosamine 6.689163691 19996281 10737359 20501860 19833225 19255062 19073162 18978307 20492335 15175105 18754104 19090486 18644402 19642983 19256749 19294768 21047994 20583210 19690152 15885732 20405173 18648771 20452335 19427195 21278145 19551842 19426721 2862719 19499222 21071580 20137499 16942905 12771043 19850985 18977376 20101389 19638242 20434301 12112319 20118626 19812893 19254457 2422723 21167192
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 6.6816984957
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 8.6712014681 15583823
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 8.6718093689 18079962 3124819 18775883 17942915 19009564 16842330 16267830 19004024 19539802 19126423 18544905 17174075 18308698 21159647 18164116 2563599 18282651 9362446 17854601 19519916 18253720
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 8.6712151625
MESH:D008175 Lung Neoplasms Dexamethasone 3.2215824018 11195469
MESH:D008175 Lung Neoplasms Diethylnitrosamine 3.226695378 21163286 20512841 20970405
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.2211884234 19555203
MESH:D008223 Lymphoma decitabine 3.2019470736
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 6.0616891317 11408345 11807958 17203775
MESH:D008325 Mammary Neoplasms, Experimental Reserpine 6.0611921183
MESH:D020149 Manganese Poisoning Estradiol 4.1719453300
MESH:D008545 Melanoma decitabine 2.2016505122 17785578
MESH:D009101 Multiple Myeloma decitabine 6.8018172295
MESH:D009101 Multiple Myeloma Dexamethasone 6.8016118317 15744524 15867202
MESH:D009190 Myelodysplastic Syndromes decitabine 7.0619157545 19010910 16882708 18608210
MESH:D009190 Myelodysplastic Syndromes Dexamethasone 7.069809623
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.7812213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 8.1716810080
MESH:D015428 Myocardial Reperfusion Injury Norepinephrine 8.1715642760
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 2.449029167 3581430
MESH:D009369 Neoplasms decitabine 2.5719116145 17925555 19470736
MESH:D009389 Neovascularization, Pathologic Estradiol 3.4217289903
MESH:D009410 Nerve Degeneration Paraquat 3.4816893418
MESH:D009421 Nervous System Malformations Estradiol 8.4811399458 16427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 8.4814600291
MESH:D019636 Neurodegenerative Diseases Amphetamine 8.0015183010
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 8.0020387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 4.8020387270
MESH:D020258 Neurotoxicity Syndromes Chlorpyrifos 3.9615081274
MESH:D007752 Obstetric Labor, Premature Terbutaline 5.8014998686
MESH:D010051 Ovarian Neoplasms decitabine 4.5719259094 19331143
MESH:D010051 Ovarian Neoplasms Estradiol 4.5719401270
MESH:D010190 Pancreatic Neoplasms decitabine 4.9819294695
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 4.9816540662
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.4011578682
MESH:D010300 Parkinson Disease Paraquat 2.7011124998 16140633 12911755 11181820 11445065 15824117 15451049 16510128
MESH:D010302 Parkinson Disease, Secondary Paraquat 4.1316190885
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 3.9312520081
MESH:D011014 Pneumonia Paraquat 4.1412504350
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.2618163543
MESH:D011230 Precancerous Conditions Diethylnitrosamine 3.292563599
MESH:D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma Dexamethasone 3.3721297632
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 2.8811118676 11896295 11399792 11222880
MESH:D055728 Primary Myelofibrosis decitabine 4.4217616702
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.6120887781
MESH:D011471 Prostatic Neoplasms Estradiol 3.1816740699
MESH:D011537 Pruritus Ethinyl Estradiol 3.0015861022 16919318
MESH:D011654 Pulmonary Edema Terbutaline 5.2010903255
MESH:D011658 Pulmonary Fibrosis Paraquat 2.7916324872 17997886
MESH:D012128 Respiratory Distress Syndrome, Adult Dexamethasone 13.7411700416 18379247
MESH:D012128 Respiratory Distress Syndrome, Adult Paraquat 13.7411700416
MESH:D012128 Respiratory Distress Syndrome, Adult Terbutaline 13.742878809
MESH:D012135 Respiratory Sounds Chlorpyrifos 8.9311874814 16611668 17119214
MESH:D012135 Respiratory Sounds Paraquat 8.9311874814
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.5418990726
MESH:D012140 Respiratory Tract Diseases Chlorpyrifos 4.5817119214 16611668
MESH:D012162 Retinal Degeneration Paraquat 3.6416458197
MESH:D012208 Rhabdomyosarcoma decitabine 4.1219155313
MESH:D012729 Sex Chromosome Aberrations Chlorpyrifos 5.776418539
MESH:D012772 Shock, Septic Terbutaline 5.183431524
MESH:D012852 Sinusitis Phenylephrine 4.397327846
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 1.9016192470
MESH:D013088 Spermatocele Ethinyl Estradiol 3.6316709447
MESH:D019956 Stereotypic Movement Disorder Amphetamine 6.111977408
MESH:D013272 Stomach Diseases Dexamethasone 4.0115472012
MESH:D013274 Stomach Neoplasms decitabine 2.4519037991
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 2.4518456281
MESH:D013276 Stomach Ulcer Dexamethasone 3.2215138204
MESH:D013610 Tachycardia Norepinephrine 10.573261545
MESH:D013610 Tachycardia Terbutaline 10.5710895896
MESH:D013705 Temporomandibular Joint Disorders polyphenols 4.9417997062
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.3311994571
MESH:D013927 Thrombosis Ethinyl Estradiol 2.8915669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.5912697716
MESH:D013964 Thyroid Neoplasms decitabine 6.5117967635
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 6.517505956
MESH:D013978 Tibial Fractures Estradiol 4.3719048282
MESH:D001749 Urinary Bladder Neoplasms decitabine 2.6019087683 17616700
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.0014692618
MESH:D014604 Uveal Neoplasms decitabine 4.6017785578
MESH:D014605 Uveitis Dexamethasone 4.501336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.2812125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.2615869587 14671159
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 3.9315886252
Pathway ID Pathway Name
KEGG:04020 Calcium signaling pathway
KEGG:04080 Neuroactive ligand-receptor interaction
KEGG:04970 Salivary secretion
REACT:14797 Signaling by GPCR
KEGG:04270 Vascular smooth muscle contraction
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA24597
    • No data
    Releated disease ID Related disease Name
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    PA443632Cardiomyopathy, Dilated
    Releated drug ID Related drug Name
    PA450379mercaptopurine
    PA450428methotrexate
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB00298 antagonist Dapiprazole Ophthalmologicals;Adrenergic alpha-Antagonists;Antimydriatics;Antipsychotic Agents
    DB00321 antagonist Triavil Tab Adrenergic Uptake Inhibitors;Analgesics, Non-Narcotic;Antidepressive Agents, Tricyclic
    DB00346 antagonist Alfuzosin Antihypertensive Agents;Adrenergic alpha-Antagonists
    DB00368 agonist Norepinephrine Vasoconstrictor Agents;Sympathomimetics;Adrenergic alpha-Agonists
    DB00388 - Vasosulf Oph Soln Vasoconstrictor Agents;Sympathomimetics;Adrenergic alpha-Agonists;Mydriatics;Cardiotonic Agents;Nasal Decongestants
    DB00420 antagonist Promazine Antiemetics;Antipsychotics;Dopamine Antagonists;Neuroleptics;Phenothiazines;Antipsychotic Agents
    DB00457 antagonist Minizide Antihypertensive Agents;Adrenergic alpha-Antagonists;Alpha-adrenergic Blocking Agents
    DB00458 antagonist Imipramine Adrenergic Uptake Inhibitors;Antidepressive Agents, Tricyclic;Norepinephrine-Reuptake Inhibitors
    DB00540 antagonist Nortriptyline Antidepressants;Adrenergic Uptake Inhibitors;Antidepressive Agents, Tricyclic;Norepinephrine-Reuptake Inhibitors
    DB00590 antagonist Doxazosin Antineoplastic Agents;Antihypertensive Agents;Vasodilator Agents;Adrenergic alpha-Antagonists;Alpha-adrenergic Blocking Agents;Antihyperplasia Agents
    DB00622 antagonist Nicardipine Antihypertensive Agents;Vasodilator Agents;Antiarrhythmic Agents;Calcium Channel Blockers;Dihydropyridines
    DB00668 antagonist Zorcaine Vasoconstrictor Agents;Sympathomimetics;Adrenergic alpha-Agonists;Mydriatics;Bronchodilator Agents;Adrenergic beta-Agonists;Adrenergic Agonists
    DB00696 partial agonist Wigraine Tab Vasoconstrictor Agents;Sympatholytics;Adrenergic alpha-Agonists;Analgesics, Non-Narcotic
    DB00706 antagonist Tamsulosin Antineoplastic Agents;Adrenergic alpha-Antagonists
    DB00777 antagonist Propiomazine Sedatives and Hypnotics
    DB01142 antagonist Doxepin Antidepressants;Anti-anxiety Agents;Antipruritics;Antidepressive Agents, Tricyclic;Norepinephrine-Reuptake Inhibitors;Histamine Antagonists
    DB01162 antagonist Terazosin Antineoplastic Agents;Adrenergic alpha-Antagonists
    DB01186 agonist Pergolide Central Nervous System Agents;Antiparkinson Agents;Antidyskinetics;Dopamine Agonists;Neuroprotective Agents
    DB01200 agonist Bromocriptine Antiparkinson Agents;Antidyskinetics;Dopamine Agonists;Hormone Antagonists
    DB01224 antagonist Quetiapine Antipsychotics;Antipsychotic Agents
    DB01403 antagonist Methotrimeprazine Dopamine Antagonists;Analgesics, Non-Narcotic;Antipsychotic Agents
    DB06144 - Sertindole Neuroleptics;Antipsychotic Agents
    DB06262 agonist Droxidopa Vasoconstrictor Agents;Sympathomimetics;Adrenergic alpha-Agonists
    DB06694 agonist Xylometazoline Sympathomimetics;Adrenergic alpha-Agonists;Nasal Decongestants
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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