AutismKB 2.0

Annotation Detail for NCAN


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Basic Information Top
Gene Symbol:NCAN ( CSPG3,FLJ44681 )
Gene Full Name: neurocan
Band: 19p12
Quick LinksEntrez ID:1463; OMIM: 600826; Uniprot ID:NCAN_HUMAN; ENSEMBL ID: ENSG00000130287; HGNC ID: 2465
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
No data
Pathway IDPathway Name
Axon guidance
Pathway IDPathway Name
200170Syndecan-3-mediated signaling events
No data
Pathway IDPathway Name
500097L1CAM interactions
500087NCAM1 interactions
Related Diseases/Disorders Top
No data
No data
Desease Name
METABOLIC
LDL cholesterol
triglycerides
cholesterol, total
Desease Name
Cholesterol, total
Triglycerides
LDL cholesterol
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C472791 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in increased expression of NCAN mRNAincreases expression 16788091
D000643 Ammonium Chloride Ammonium Chloride affects the expression of NCAN mRNAaffects expression 16483693
D002251 Carbon Tetrachloride Carbon Tetrachloride results in increased expression of NCAN mRNAincreases expression 16644059
D003024 Clozapine Clozapine results in decreased expression of NCAN mRNAdecreases expression 18797397
D006220 Haloperidol Haloperidol results in decreased expression of NCAN mRNAdecreases expression 18797397
C076029 olanzapine olanzapine results in decreased expression of NCAN mRNAdecreases expression 18797397
C035988 procymidone procymidone results in increased expression of NCAN mRNAincreases expression 15686871
C025643 vinclozolin vinclozolin results in increased expression of NCAN mRNAincreases expression 15686871
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 3.9018287403
MESH:D000380 Agranulocytosis Clozapine 5.3612649775 14617031 16160616
MESH:D001008 Anxiety Disorders vinclozolin 3.8319015723
MESH:D001321 Autistic Disorder Haloperidol 2.8418080171 19368416
MESH:D001321 Autistic Disorder olanzapine 2.8417069543 18685284
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 4.0815700767 16011737 15673190 10355542 16050911 16097048 16192424 18705752 3786805 16124888 15721981 16227642
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 1.8518788625
MESH:D002375 Catalepsy Haloperidol 5.2515215559 1977408
MESH:D002389 Catatonia olanzapine 6.6318071103 16772815
MESH:D003072 Cognition Disorders Clozapine 5.2717123785
MESH:D003456 Cryptorchidism vinclozolin 4.6214966744
MESH:D016757 Death, Sudden, Cardiac Haloperidol 5.1020210726
MESH:D003704 Dementia Haloperidol 4.8211575062
MESH:D002658 Developmental Disabilities olanzapine 4.8417069543
MESH:D003924 Diabetes Mellitus, Type 2 Clozapine 3.0216402076
MESH:D006970 Disorders of Excessive Somnolence Clozapine 5.9315331141
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 2.097440962 7179309 2869522 3786805 9327722 21278145 16227642 15998439 4309450 6623471 17522070 6884620 19085960 3732212 15968718 7120509 16177239 10092053 11566570 10915739 15027814 19336974
MESH:D050171 Dyslipidemias Clozapine 4.3516402076
MESH:D005234 Fatty Liver Carbon Tetrachloride 3.4112631006 17595544 15959796 61145 16239168 19224547 12795759 16045604
MESH:D005355 Fibrosis Carbon Tetrachloride 3.7618705752
MESH:D030342 Genetic Diseases, Inborn vinclozolin 5.2716973722
MESH:D005832 Genital Diseases, Male vinclozolin 5.6816417039
MESH:D006505 Hepatitis Carbon Tetrachloride 3.8819900420 19110552
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.8716899240
MESH:D006948 Hyperkinesis Clozapine 5.2516046005
MESH:D006963 Hyperphagia olanzapine 6.5717933447
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.3915338365
MESH:D007248 Infertility, Male vinclozolin 3.1916467254
MESH:D007984 Leydig Cell Tumor vinclozolin 5.0716417039
MESH:D008064 Lipidoses Clozapine 4.1317567588
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 2.9221278145 17174718 16943688 17157831 17334410 11903743 11408273 16221502 16239168
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 1.7516136751 17708605 14512876 15052691 15370692 15893842 12666154 16033810 17823541 17631135 16011737 16248980 18251166 15650968 18277467 16192424 16015684 17805973 12445418 18187930 17714472 10355542 17976157 17565644 12649538 12741479 14716833 15057751 15931870 18156304 18472094 18429990 15818738 20821823 17922224 17900296 18395095 17525996 18412020 18317297 17557913 12586293 12609069 17640975 12389079 12632512 18054572 18166357 17698563 17944888 17481882 12632514 17869086 15673190 18395914 14724832 15925388 15730626 18420326 18418968 12898905 15123356 18006644 16027843 16638106 16116963 14620537 15338365 18263696 16097048 14716496 18279442 12546737 13678700 18472332 17761835 14748882 12445421 18376398 15996030 15876570 12667390 15362042 18481824 12958196 18705752 17766677 17721639 18205269 18339082 15959796 11481614 18210741
MESH:D008107 Liver Diseases Carbon Tetrachloride 2.1317285989 15720792 16246199 15830285 16964402
MESH:D017093 Liver Failure Carbon Tetrachloride 4.4715123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 3.9214706259 16899240
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 2.2919294768
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 2.7512014681 15583823
MESH:D008133 Long QT Syndrome olanzapine 4.9120210726
MESH:D001523 Mental Disorders Clozapine 15.5216856516
MESH:D001523 Mental Disorders Haloperidol 15.5216856516
MESH:D001523 Mental Disorders olanzapine 15.5216856516
MESH:D008659 Metabolic Diseases olanzapine 5.6319142110
MESH:D024821 Metabolic Syndrome X Clozapine 4.6119142101
MESH:D009765 Obesity Clozapine 5.5718515891 19142110
MESH:D009765 Obesity olanzapine 5.5718515891
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 4.2319015723 18220299 18042343
MESH:D011469 Prostatic Diseases vinclozolin 5.2718220299
MESH:D011472 Prostatitis vinclozolin 5.2718629315
MESH:D011595 Psychomotor Agitation Haloperidol 12.8611575062
MESH:D011595 Psychomotor Agitation olanzapine 12.8618685284
MESH:D011618 Psychotic Disorders Clozapine 9.7215331141
MESH:D011618 Psychotic Disorders Haloperidol 9.7211575062
MESH:D012559 Schizophrenia Clozapine 6.0811151749 18855531 18806925 11763009 19369910 20580759 17123785 20168265 16141801 20452607 20521320 17726453 17667964 20107430 20521326
MESH:D012559 Schizophrenia Haloperidol 6.0820107430 18513383 19369910 1830565
MESH:D012559 Schizophrenia olanzapine 6.0820107430 20521326 17726453
MESH:D017180 Tachycardia, Ventricular Haloperidol 11.9120210726
MESH:D017180 Tachycardia, Ventricular olanzapine 11.9120210726
MESH:D015430 Weight Gain Clozapine 11.0716141801 17502770 16402076 20107430 20564506 20521320
MESH:D015430 Weight Gain olanzapine 11.0720107430 17933447 19434072
MESH:D015431 Weight Loss Clozapine 5.4117933447
Pathway ID Pathway Name
REACT:18266 Axon guidance
Pharmacogenomics Knowledge Base Top
Drug Bank Top
Drugbank ID Action Drug Name Description
DB02379 - Beta-D-Glucose Sweetening Agents
DB04396 - Thiodigalactoside
No data
No data
No data

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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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