AutismKB 2.0

Annotation Detail for ADRA1B


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Basic Information Top
Gene Symbol:ADRA1B ( ADRA1,ALPHA1BAR )
Gene Full Name: adrenergic, alpha-1B-, receptor
Band: 5q33.3
Quick LinksEntrez ID:147; OMIM: 104220; Uniprot ID:ADA1B_HUMAN; ENSEMBL ID: ENSG00000170214; HGNC ID: 278
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04270Vascular smooth muscle contraction
hsa04080Neuroactive ligand-receptor interaction
hsa04020Calcium signaling pathway
hsa04970Salivary secretion
Pathway IDPathway Name
Signaling by GPCR
Pathway IDPathway Name
200011LPA receptor mediated events
Pathway IDPathway Name
P00026Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
P00002Alpha adrenergic receptor signaling pathway
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1902Kidney failure
No data
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C099060 1-(2-(3-methoxyphenyl)ethyl)phenoxy-3-(dimethylamino)-2-propanol 1-(2-(3-methoxyphenyl)ethyl)phenoxy-3-(dimethylamino)-2-propanol inhibits the reaction [Prazosin binds to ADRA1B protein]affects binding|decreases reaction 11937776
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of ADRA1B mRNAaffects expression 21346803
D015761 4-Aminopyridine 4-Aminopyridine inhibits the reaction [ADRA1B protein results in increased susceptibility to Phenylephrine]decreases reaction|increases response to substance 18480251
D000643 Ammonium Chloride Ammonium Chloride affects the expression of ADRA1B mRNAaffects expression 16483693
C015001 arsenite arsenite results in increased expression of ADRA1B mRNAincreases expression 18191166
C095105 bexarotene bexarotene results in decreased expression of ADRA1B mRNAdecreases expression 16648578
D001761 Bleomycin Bleomycin results in decreased expression of ADRA1B mRNAdecreases expression 15808516
C053428 BMY 7378 BMY 7378 binds to ADRA1B proteinaffects binding 16195468
C053428 BMY 7378 BMY 7378 binds to [ADRA1B protein binds to ADRA1D protein]affects binding 16195468
D002118 Calcium [Phenylephrine results in increased activity of ADRA1B protein] which results in increased abundance of Calciumincreases abundance|increases activity 16498073
C059041 calyculin A calyculin A results in increased phosphorylation of ADRA1B proteinincreases phosphorylation 10683197
D002251 Carbon Tetrachloride Carbon Tetrachloride results in decreased expression of ADRA1B mRNAdecreases expression 17484886
D002330 Carmustine Carmustine results in decreased expression of ADRA1B mRNAdecreases expression 15980968
C051731 chlorethylclonidine chlorethylclonidine binds to and results in decreased activity of ADRA1B proteinaffects binding|decreases activity 18480251
C051731 chlorethylclonidine chlorethylclonidine inhibits the reaction [ADRA1B protein results in increased susceptibility to Phenylephrine]decreases reaction|increases response to substance 18480251
C080462 cyclazosin cyclazosin binds to and results in decreased activity of ADRA1B proteinaffects binding|decreases activity 15951348
C017160 cypermethrin cypermethrin results in increased phosphorylation of ADRA1B proteinincreases phosphorylation 10683197
D003907 Dexamethasone Dexamethasone results in increased expression of ADRA1B mRNAincreases expression 10229127
D003907 Dexamethasone Dexamethasone results in increased expression of ADRA1B proteinincreases expression 10229127
D004051 Diethylhexyl Phthalate Diethylhexyl Phthalate results in increased expression of ADRA1B mRNAincreases expression 15620428
D004052 Diethylnitrosamine Diethylnitrosamine results in decreased expression of ADRA1B mRNAdecreases expression 19638242
D002117 Calcitriol Calcitriol results in increased expression of ADRA1B mRNAincreases expression 16002434
D004958 Estradiol Estradiol promotes the reaction [ADRA1B protein results in increased susceptibility to Phenylephrine]increases reaction|increases response to substance 18480251
D004958 Estradiol Estradiol results in increased expression of ADRA1B mRNAincreases expression 18480251
D004958 Estradiol Estradiol results in increased expression of ADRA1B proteinincreases expression 18480251
D007650 Ketanserin Ketanserin inhibits the reaction [Prazosin binds to ADRA1B protein]affects binding|decreases reaction 11937776
D015544 Inositol 1,4,5-Trisphosphate ADRA1B protein results in increased metabolism of Inositol 1,4,5-Trisphosphateincreases metabolic processing 11278430
D019319 Okadaic Acid Okadaic Acid results in increased phosphorylation of ADRA1B proteinincreases phosphorylation 10683197
D019319 Okadaic Acid Ro 31-8220 inhibits the reaction [Okadaic Acid results in increased phosphorylation of ADRA1B protein]decreases reaction|increases phosphorylation 10683197
D019319 Okadaic Acid Staurosporine inhibits the reaction [Okadaic Acid results in increased phosphorylation of ADRA1B protein]decreases reaction|increases phosphorylation 10683197
D010634 Phenobarbital Phenobarbital results in increased expression of ADRA1B mRNAincreases expression 19270015
D010656 Phenylephrine ADRA1B protein affects the susceptibility to Phenylephrineaffects response to substance 18257748
D010656 Phenylephrine Phenylephrine results in increased activity of ADRA1B proteinincreases activity 16498073
D010656 Phenylephrine [Phenylephrine results in increased activity of ADRA1B protein] which results in increased abundance of Calciumincreases abundance|increases activity 16498073
D010656 Phenylephrine ADRA1B protein results in increased susceptibility to Phenylephrineincreases response to substance 11499749
D010656 Phenylephrine [Phenylephrine co-treated with ADRA1B protein] results in decreased expression of ATP2A2 proteinaffects cotreatment|decreases expression 11499749
D010656 Phenylephrine [Phenylephrine co-treated with ADRA1B protein] results in decreased expression of NPY proteinaffects cotreatment|decreases expression 11499749
D010656 Phenylephrine [Phenylephrine co-treated with ADRA1B protein] results in increased expression of ACTA1 proteinaffects cotreatment|increases expression 11499749
D010656 Phenylephrine [Phenylephrine co-treated with ADRA1B protein] results in increased expression of ADRBK1 proteinaffects cotreatment|increases expression 11499749
D010656 Phenylephrine [Phenylephrine co-treated with ADRA1B protein] results in increased expression of NPPA proteinaffects cotreatment|increases expression 11499749
D010656 Phenylephrine Phenylephrine results in increased expression of ADRA1B mRNAincreases expression 17122163
D010656 Phenylephrine 4-Aminopyridine inhibits the reaction [ADRA1B protein results in increased susceptibility to Phenylephrine]decreases reaction|increases response to substance 18480251
D010656 Phenylephrine ADRA1B protein affects the reaction [Phenylephrine results in decreased activity of TGM2 protein]affects reaction|decreases activity 10801782
D010656 Phenylephrine ADRA1B protein results in increased susceptibility to Phenylephrineincreases response to substance 18480251
D010656 Phenylephrine chlorethylclonidine inhibits the reaction [ADRA1B protein results in increased susceptibility to Phenylephrine]decreases reaction|increases response to substance 18480251
D010656 Phenylephrine Estradiol promotes the reaction [ADRA1B protein results in increased susceptibility to Phenylephrine]increases reaction|increases response to substance 18480251
D010656 Phenylephrine Phenylephrine results in decreased expression of ADRA1B mRNAdecreases expression 11693201
D010656 Phenylephrine Phenylephrine results in decreased expression of ADRA1B proteindecreases expression 11693201
D010656 Phenylephrine Phenylephrine results in increased activity of ADRA1B proteinincreases activity 19376108
D010716 Phosphatidylinositols ADRA1B protein results in increased hydrolysis of Phosphatidylinositolsincreases hydrolysis 11195782
D010795 Phthalic Acids Phthalic Acids results in decreased expression of ADRA1B mRNAdecreases expression 15728792
D010852 Picrotoxin Picrotoxin results in increased expression of ADRA1B mRNAincreases expression 15170462
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of ADRA1B mRNAaffects binding|decreases expression|increases activity 19710929
D011224 Prazosin 1-(2-(3-methoxyphenyl)ethyl)phenoxy-3-(dimethylamino)-2-propanol inhibits the reaction [Prazosin binds to ADRA1B protein]affects binding|decreases reaction 11937776
D011224 Prazosin Ketanserin inhibits the reaction [Prazosin binds to ADRA1B protein]affects binding|decreases reaction 11937776
D011224 Prazosin sarpogrelate inhibits the reaction [Prazosin binds to ADRA1B protein]affects binding|decreases reaction 11937776
C064758 Ro 31-8220 Ro 31-8220 inhibits the reaction [Okadaic Acid results in increased phosphorylation of ADRA1B protein]decreases reaction|increases phosphorylation 10683197
C064294 sarpogrelate sarpogrelate inhibits the reaction [Prazosin binds to ADRA1B protein]affects binding|decreases reaction 11937776
D019311 Staurosporine Staurosporine inhibits the reaction [Okadaic Acid results in increased phosphorylation of ADRA1B protein]decreases reaction|increases phosphorylation 10683197
D013311 Streptozocin Streptozocin results in increased expression of ADRA1B mRNAincreases expression 19298542
D013654 Taurine Taurine results in increased expression of ADRA1B mRNAincreases expression 16579726
C053079 tautomycin tautomycin results in increased phosphorylation of ADRA1B proteinincreases phosphorylation 10683197
D013726 Terbutaline Terbutaline results in increased expression of ADRA1B mRNAincreases expression 10229127
D013726 Terbutaline Terbutaline results in increased expression of ADRA1B proteinincreases expression 10229127
D013755 Tetradecanoylphorbol Acetate Tetradecanoylphorbol Acetate results in increased phosphorylation of ADRA1B proteinincreases phosphorylation 10683197
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Diethylhexyl Phthalate 12.356734493
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 12.356195326
MESH:D000014 Abnormalities, Drug-Induced Terbutaline 12.3514610225
MESH:D000138 Acidosis Ammonium Chloride 3.1718287403
MESH:D055371 Acute Lung Injury Bleomycin 8.1517118201
MESH:D055371 Acute Lung Injury pirinixic acid 8.1518653653
MESH:D000230 Adenocarcinoma Estradiol 2.0011473722
MESH:D000236 Adenoma Diethylnitrosamine 2.6210737359 6695378
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 15.0719061943 19052882 16434500 17620307 18056438 17162532
MESH:D018248 Adenoma, Liver Cell Phenobarbital 15.0717620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 15.0716434500
MESH:D000382 Agricultural Workers' Diseases cypermethrin 4.5416487989
MESH:D000686 Amyloidosis Terbutaline 5.257986221
MESH:D000860 Anoxia Bleomycin 5.0115782499
MESH:D001145 Arrhythmias, Cardiac Phenylephrine 3.7717460149
MESH:D001169 Arthritis, Experimental Dexamethasone 3.2917659584
MESH:D001289 Attention Deficit Disorder with Hyperactivity Phthalic Acids 4.0920106747
MESH:D001321 Autistic Disorder Terbutaline 3.4817400887 16417856
MESH:D001778 Blood Coagulation Disorders pirinixic acid 2.8019483382
MESH:D001919 Bradycardia Phenylephrine 4.1515306635
MESH:D001932 Brain Neoplasms Carmustine 4.0516187019
MESH:D001943 Breast Neoplasms bexarotene 1.9516818667 16344269
MESH:D001943 Breast Neoplasms Calcitriol 1.9511237771
MESH:D001943 Breast Neoplasms Diethylnitrosamine 1.9517474063
MESH:D001943 Breast Neoplasms Estradiol 1.9519861407 12948864 17018787 16675129 18497071 17289903 14630087 17261762
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.0716111702
MESH:D019559 Capillary Leak Syndrome Terbutaline 5.4611713377 9428835
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.4015700767 15721981 16227642 18705752 16192424 16011737 15673190 16124888 16050911 16097048 10355542 3786805
MESH:D002276 Carcinoid Tumor Streptozocin 5.2016051944
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 8.0716705839
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 8.0718788625
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 8.0719171122 3084413 20935162 20514400 18978308 16878318 19335982 19208518 3581430 17761372 19519916 18788625 17173139 16502159 11831363 20727157 18785209 16328049 19822196 18393292 19394651 19052882 17978847 18210153 21159647 20214788 16288022 10737359 16779866 19418558 18506893 17162532 19701751 19383236 20084675 20512989 20524982 18494052 20007298 16540662 19539802 10672840 16807293 20432363 17428255 18691550 17138121 16935385 19919837 16681979 16698587 17055752 16830150 19107877 18665156 18056438 20101231 18971187 16569478
MESH:D006528 Carcinoma, Hepatocellular Estradiol 8.0716924424
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 8.076705139 1701930 17173139 20007298 20935162
MESH:D002289 Carcinoma, Non-Small-Cell Lung bexarotene 3.0816247446
MESH:D002294 Carcinoma, Squamous Cell Bleomycin 7.096189445
MESH:D002294 Carcinoma, Squamous Cell Calcitriol 7.0911237771
MESH:D002294 Carcinoma, Squamous Cell Tetradecanoylphorbol Acetate 7.0918922899
MESH:D006332 Cardiomegaly marker/mechanism 11278430
MESH:D006332 Cardiomegaly Phenylephrine 3.3115728586 11754973 17124262 17287366 16170337 11179087
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 5.7917174075 7505956 21159647 2727394
MESH:D002471 Cell Transformation, Neoplastic Estradiol 5.7918566989
MESH:D002493 Central Nervous System Diseases Phenobarbital 3.874080065
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 3.3519052882
MESH:D002779 Cholestasis pirinixic acid 2.5419176532
MESH:D003110 Colonic Neoplasms arsenite 3.7815037631
MESH:D003110 Colonic Neoplasms Dexamethasone 3.7815824018
MESH:D003371 Cough Terbutaline 5.1619679606
MESH:D019465 Craniofacial Abnormalities Dexamethasone 2.2617728286
MESH:D003490 Cyanosis 2,4-dinitrotoluene 3.6318551238
MESH:D017449 Dermatitis, Allergic Contact Dexamethasone 3.0412438553
MESH:D003876 Dermatitis, Atopic Diethylhexyl Phthalate 6.3416882537
MESH:D003876 Dermatitis, Atopic pirinixic acid 6.3418249437
MESH:D003920 Diabetes Mellitus Streptozocin 4.4016285004
MESH:D003921 Diabetes Mellitus, Experimental Streptozocin 4.1611055810 16684804 12446591 19298542 2177838 6379147 18603373 7637645 15862027 15298345 19496084 8740154 18715473 12644472 15831366 16286809 17442507 19960420 12093613 17874149 1374869 12083368 11260395 19586609
MESH:D003922 Diabetes Mellitus, Type 1 Streptozocin 3.5118603373
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 4.4820387270
MESH:D003924 Diabetes Mellitus, Type 2 Streptozocin 4.4819586609 19647726
MESH:D058065 Diabetic Cardiomyopathies Streptozocin 12.2916025228
MESH:D058065 Diabetic Cardiomyopathies Taurine 12.2916025228
MESH:D003928 Diabetic Nephropathies Estradiol 8.1819279558
MESH:D003928 Diabetic Nephropathies Streptozocin 8.1819682444 19960420
MESH:D003930 Diabetic Retinopathy Streptozocin 5.0517662242
MESH:D003967 Diarrhea Dexamethasone 3.337237001
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 10.6818551238 21346803
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 10.687120509 19085960 3732212 11566570 3786805 17522070 19336974 15998439 10092053 16177239 21278145 15968718 9327722 6623471 6884620 7440962 7179309 4309450 10915739 16227642 2869522 15027814
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 10.6819107877
MESH:D056486 Drug-Induced Liver Injury Prazosin 10.6818071297
MESH:D056486 Drug-Induced Liver Injury Taurine 10.689328219
MESH:D004417 Dyspnea cypermethrin 4.9916487989
MESH:D004421 Dystonia Phenobarbital 3.641851702
MESH:D004485 Eczema Dexamethasone 4.0912438553
MESH:D004487 Edema Bleomycin 18.0117118201
MESH:D004487 Edema Dexamethasone 18.0119703484
MESH:D004487 Edema pirinixic acid 18.0112083418
MESH:D004487 Edema Staurosporine 18.018273558
MESH:D004487 Edema Tetradecanoylphorbol Acetate 18.018113982 8273558 16716910 9599246 7812673 15177302 11698051
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Calcitriol 3.5615138306
MESH:D016889 Endometrial Neoplasms Estradiol 2.7211473722 18566989 19148513
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 3.723659116
MESH:D004828 Epilepsies, Partial Phenobarbital 3.4711558140 3922381
MESH:D004827 Epilepsy Phenobarbital 2.6820417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.216401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 3.877750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 3.633659116
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 4.7116302075
MESH:D005234 Fatty Liver arsenite 15.9218296743
MESH:D005234 Fatty Liver Carbon Tetrachloride 15.9215959796 16045604 19224547 16239168 61145 17595544 12631006 12795759
MESH:D005234 Fatty Liver Diethylnitrosamine 15.9221071580 20387270
MESH:D005234 Fatty Liver pirinixic acid 15.9220131406 19236843
MESH:D005355 Fibrosis arsenite 12.8918296743
MESH:D005355 Fibrosis Carbon Tetrachloride 12.8918705752
MESH:D005355 Fibrosis Terbutaline 12.8915467267
MESH:D005909 Glioblastoma Carmustine 7.1916187019
MESH:D005909 Glioblastoma Okadaic Acid 7.1917312396
MESH:D006331 Heart Diseases Streptozocin 4.0012093613
MESH:D006333 Heart Failure pirinixic acid 2.2920558911
MESH:D018883 Heat Stroke Ketanserin 6.7716205318
MESH:D006505 Hepatitis Carbon Tetrachloride 8.5919900420 19110552
MESH:D006505 Hepatitis cypermethrin 8.5916487989
MESH:D006529 Hepatomegaly Phenobarbital 7.2116109766
MESH:D006529 Hepatomegaly pirinixic acid 7.2118467677 16221962 19772884 19176532
MESH:D006548 Hernia, Diaphragmatic Dexamethasone 2.937520565
MESH:D006558 Herpes Genitalis Estradiol 4.6315709030
MESH:D006689 Hodgkin Disease Bleomycin 4.0517606976 18501091 15147373
MESH:D019584 Hot Flashes Estradiol 3.3517088409
MESH:D006930 Hyperalgesia Prazosin 4.5612727271
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.1416899240
MESH:D006943 Hyperglycemia pirinixic acid 2.8420558911
MESH:D006973 Hypertension Dexamethasone 5.1517042910
MESH:D006973 Hypertension Phenylephrine 5.158949925 12717712
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 3.7015338365
MESH:D006984 Hypertrophy Phenylephrine 4.2012791704 18502941
MESH:D006985 Hyperventilation Terbutaline 5.6910895896
MESH:D007008 Hypokalemia Terbutaline 5.7017292646
MESH:D007022 Hypotension marker/mechanism 11278430
MESH:D007249 Inflammation Bleomycin 10.3417118201
MESH:D007249 Inflammation Dexamethasone 10.3411099482 8960868
MESH:D007249 Inflammation Diethylnitrosamine 10.3418785209
MESH:D007249 Inflammation Tetradecanoylphorbol Acetate 10.3415177302 8273558 7812673 7562506 11698051
MESH:D007299 Insect Bites and Stings cypermethrin 5.5715189238
MESH:D007333 Insulin Resistance Estradiol 6.3316393666 16627594
MESH:D007333 Insulin Resistance pirinixic acid 6.3316306350
MESH:D007674 Kidney Diseases marker/mechanism 18257748
MESH:D007674 Kidney Diseases Estradiol 5.7215618244
MESH:D007674 Kidney Diseases Streptozocin 5.7212093613
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 6.3116705839
MESH:D007680 Kidney Neoplasms Estradiol 6.3115610895
MESH:D007683 Kidney Tubular Necrosis, Acute Calcium 4.6416316344
MESH:D053609 Lethargy Terbutaline 5.9110895896
MESH:D008103 Liver Cirrhosis arsenite 13.9418296743
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 13.9421278145 11408273 17334410 16943688 17174718 11903743 17157831 16221502 16239168
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 13.9418522880 19638242 18665156 18407596 20032147
MESH:D008103 Liver Cirrhosis Phenobarbital 13.9421047994
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 6.1512546737 17900296 17708605 12609069 12445418 18481824 15370692 12632512 14512876 20821823 17823541 18187930 12666154 17481882 14716496 16033810 17557913 17976157 15925388 18472094 14620537 16011737 18006644 17565644 12389079 18472332 17698563 18277467 15818738 15052691 17761835 16116963 12898905 12649538 17714472 16136751 18054572 17922224 18412020 15057751 18251166 18317297 18376398 16638106 16015684 18420326 18395914 15931870 12741479 17631135 12586293 18263696 12958196 18166357 15876570 16192424 18156304 15893842 18418968 15362042 13678700 16097048 17640975 17869086 15730626 15959796 16027843 11481614 17766677 14748882 17525996 17944888 18205269 14716833 12445421 18395095 17805973 18705752 10355542 15650968 16248980 18339082 15673190 14724832 15338365 15123356 17721639 15996030 18210741 18429990 18279442 12667390 12632514
MESH:D008106 Liver Cirrhosis, Experimental Dexamethasone 6.1516718785
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 6.1514716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 6.1515474484
MESH:D008106 Liver Cirrhosis, Experimental Taurine 6.1515931870 15893842
MESH:D008107 Liver Diseases Carbon Tetrachloride 8.5015830285 16964402 16246199 17285989 15720792
MESH:D008107 Liver Diseases cypermethrin 8.5015991261
MESH:D008107 Liver Diseases Diethylnitrosamine 8.5017034775
MESH:D008107 Liver Diseases Phenobarbital 8.5019363144
MESH:D017093 Liver Failure Carbon Tetrachloride 3.7815123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 3.3516899240 14706259
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 12.5419294768
MESH:D008113 Liver Neoplasms Diethylhexyl Phthalate 12.5411940454
MESH:D008113 Liver Neoplasms Diethylnitrosamine 12.5419812893 12112319 19254457 19642983 20101389 21278145 20452335 19690152 18648771 20492335 18754104 19427195 19294768 21071580 18644402 19499222 15885732 19426721 20501860 10737359 20583210 19638242 19255062 2862719 20434301 20405173 19090486 19256749 19551842 19073162 15175105 16942905 21167192 20137499 18977376 19833225 19850985 9163691 18978307 12771043 20118626 21047994 2422723 19996281
MESH:D008113 Liver Neoplasms Phenobarbital 12.5419073162 8742319 15975961 19812893 21047994 19482888
MESH:D008113 Liver Neoplasms pirinixic acid 12.5420007298 15890375 16377806
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 8.4315583823 12014681
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 8.4319539802 16842330 18544905 3124819 16267830 18164116 18079962 19126423 19009564 9362446 18775883 18308698 19519916 17942915 21159647 18093689 19004024 18253720 18282651 17854601 17174075 2563599
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 8.4317172636 1399818 18308698 2563599 6150874
MESH:D008175 Lung Neoplasms arsenite 7.8316809336
MESH:D008175 Lung Neoplasms bexarotene 7.8317849452
MESH:D008175 Lung Neoplasms Bleomycin 7.836189445
MESH:D008175 Lung Neoplasms Dexamethasone 7.8311195469 15824018
MESH:D008175 Lung Neoplasms Diethylnitrosamine 7.836695378 20970405 21163286 20512841
MESH:D008175 Lung Neoplasms Tetradecanoylphorbol Acetate 7.8311807781
MESH:D016410 Lymphoma, T-Cell, Cutaneous bexarotene 4.7611161223
MESH:D008325 Mammary Neoplasms, Experimental bexarotene 8.6615591091 19196722 19196723
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 8.6616891317 17203775 11807958 11408345
MESH:D008325 Mammary Neoplasms, Experimental Tetradecanoylphorbol Acetate 8.668985016
MESH:D020149 Manganese Poisoning Estradiol 4.0819453300
MESH:D008545 Melanoma Bleomycin 3.8815577320
MESH:D008545 Melanoma Carmustine 3.8812393984
MESH:D009101 Multiple Myeloma Dexamethasone 3.2316118317 15867202 15744524
MESH:D009103 Multiple Sclerosis 4-Aminopyridine 5.3219915712
MESH:D009135 Muscular Diseases pirinixic acid 3.1216239165
MESH:D009190 Myelodysplastic Syndromes Dexamethasone 3.319809623
MESH:D009203 Myocardial Infarction pirinixic acid 1.9719151258
MESH:D015428 Myocardial Reperfusion Injury Estradiol 7.2516810080
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 7.2516411023
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.0817484760
MESH:D009336 Necrosis 2,4-dinitrotoluene 3.4718551238
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 2.403581430 9029167
MESH:D009369 Neoplasms pirinixic acid 1.7617405874
MESH:D009376 Neoplasms, Hormone-Dependent bexarotene 4.3819196722
MESH:D009389 Neovascularization, Pathologic arsenite 8.8415738583
MESH:D009389 Neovascularization, Pathologic Estradiol 8.8417289903
MESH:D009421 Nervous System Malformations Estradiol 3.2816427766 11399458
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 3.0220387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 4.7120387270
MESH:D009765 Obesity pirinixic acid 1.7120558911
MESH:D007752 Obstetric Labor, Premature Terbutaline 5.7114998686
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 3.0916049721 12819281
MESH:D010018 Osteomalacia Phenobarbital 3.9717016548
MESH:D010024 Osteoporosis Calcium 3.5417882678
MESH:D010051 Ovarian Neoplasms Estradiol 2.0919401270
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 7.8016540662
MESH:D010190 Pancreatic Neoplasms Phenobarbital 7.8016965848
MESH:D010190 Pancreatic Neoplasms Tetradecanoylphorbol Acetate 7.8015976015
MESH:D010212 Papilloma Tetradecanoylphorbol Acetate 3.918330346 18404319 12065085 18922899
MESH:D011014 Pneumonia Bleomycin 5.0117071938 16317386 18024389
MESH:D011230 Precancerous Conditions Diethylnitrosamine 7.992563599
MESH:D011230 Precancerous Conditions Phenobarbital 7.992563599
MESH:D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma Dexamethasone 3.3221297632
MESH:D011470 Prostatic Hyperplasia Calcitriol 4.3815572423
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.5320887781
MESH:D011471 Prostatic Neoplasms Calcitriol 3.4816289102 15754350 16644109 12479363 18247401
MESH:D011471 Prostatic Neoplasms Estradiol 3.4816740699
MESH:D019310 Pseudolymphoma Phenobarbital 4.0912752131
MESH:D011654 Pulmonary Edema Bleomycin 10.2115808516
MESH:D011654 Pulmonary Edema Terbutaline 10.2110903255
MESH:D011658 Pulmonary Fibrosis Bleomycin 3.7118162602 12624602 21435439 17241526 15322207 14609568 17177178 11554783 17434272 12574379 16314464 16115399 18008008 15541506
MESH:D015427 Reperfusion Injury pirinixic acid 2.1919058328
MESH:D012128 Respiratory Distress Syndrome, Adult Dexamethasone 8.4818379247 11700416
MESH:D012128 Respiratory Distress Syndrome, Adult Terbutaline 8.482878809
MESH:D012640 Seizures 2,4-dinitrotoluene 8.4518551238
MESH:D012640 Seizures Phenobarbital 8.454039156 3137016 16876388 11442880
MESH:D012640 Seizures Picrotoxin 8.458635557 8954991
MESH:D003294 Seizures, Febrile Phenobarbital 4.436407741
MESH:D012772 Shock, Septic Terbutaline 5.103431524
MESH:D012852 Sinusitis Phenylephrine 4.317327846
MESH:D012878 Skin Neoplasms Okadaic Acid 5.9712628509
MESH:D012878 Skin Neoplasms Tetradecanoylphorbol Acetate 5.9718404319 11807781 8330346 12065085 8985016
MESH:D013272 Stomach Diseases Dexamethasone 3.9315472012
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 1.7518456281
MESH:D013276 Stomach Ulcer Dexamethasone 3.1515138204
MESH:D013610 Tachycardia Terbutaline 5.1310895896
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 6.197505956
MESH:D013964 Thyroid Neoplasms Phenobarbital 6.191399818
MESH:D013978 Tibial Fractures Estradiol 4.2819048282
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 2.1316049721
MESH:D014570 Urologic Diseases cypermethrin 5.4616487989
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 3.9210091137
MESH:D014605 Uveitis Dexamethasone 4.421336536
MESH:D015431 Weight Loss Bleomycin 5.2512624602
Pathway ID Pathway Name
KEGG:04020 Calcium signaling pathway
KEGG:04080 Neuroactive ligand-receptor interaction
KEGG:04970 Salivary secretion
REACT:14797 Signaling by GPCR
KEGG:04270 Vascular smooth muscle contraction
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA33
    • No data
    Releated disease ID Related disease Name
    PA443450Asthma
    Releated drug ID Related drug Name
    PA450649norepinephrine
    PA451093prazosin
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB00211 agonist Midodrine Vasoconstrictor Agents;Sympathomimetics;Adrenergic alpha-Agonists
    DB00246 antagonist Ziprasidone Antipsychotics;Dopamine Antagonists;Serotonin Antagonists;Antipsychotic Agents
    DB00298 antagonist Dapiprazole Ophthalmologicals;Adrenergic alpha-Antagonists;Antimydriatics;Antipsychotic Agents
    DB00334 antagonist Olanzapine Antiemetics;Antipsychotics;Antipsychotic Agents;Serotonin Uptake Inhibitors
    DB00346 antagonist Alfuzosin Antihypertensive Agents;Adrenergic alpha-Antagonists
    DB00363 antagonist Clozapine Antipsychotics;Serotonin Antagonists;Antipsychotic Agents;GABA Antagonists
    DB00368 agonist Norepinephrine Vasoconstrictor Agents;Sympathomimetics;Adrenergic alpha-Agonists
    DB00388 - Vasosulf Oph Soln Vasoconstrictor Agents;Sympathomimetics;Adrenergic alpha-Agonists;Mydriatics;Cardiotonic Agents;Nasal Decongestants
    DB00420 antagonist Promazine Antiemetics;Antipsychotics;Dopamine Antagonists;Neuroleptics;Phenothiazines;Antipsychotic Agents
    DB00457 antagonist Minizide Antihypertensive Agents;Adrenergic alpha-Antagonists;Alpha-adrenergic Blocking Agents
    DB00477 antagonist Chlorpromazine Antiemetics;Antipsychotics;Dopamine Antagonists;Phenothiazines;Antipsychotic Agents
    DB00590 antagonist Doxazosin Antineoplastic Agents;Antihypertensive Agents;Vasodilator Agents;Adrenergic alpha-Antagonists;Alpha-adrenergic Blocking Agents;Antihyperplasia Agents
    DB00598 antagonist Labetalol Antihypertensive Agents;Adrenergic beta-Antagonists;Sympatholytics;Adrenergic alpha-Antagonists
    DB00622 antagonist Nicardipine Antihypertensive Agents;Vasodilator Agents;Antiarrhythmic Agents;Calcium Channel Blockers;Dihydropyridines
    DB00668 agonist Zorcaine Vasoconstrictor Agents;Sympathomimetics;Adrenergic alpha-Agonists;Mydriatics;Bronchodilator Agents;Adrenergic beta-Agonists;Adrenergic Agonists
    DB00679 antagonist Thioridazine Antipsychotics;Dopamine Antagonists;Phenothiazines;Antipsychotic Agents
    DB00696 partial agonist Wigraine Tab Vasoconstrictor Agents;Sympatholytics;Adrenergic alpha-Agonists;Analgesics, Non-Narcotic
    DB00706 antagonist Tamsulosin Antineoplastic Agents;Adrenergic alpha-Antagonists
    DB00723 agonist Methoxamine Vasoconstrictor Agents;Sympathomimetics;Adrenergic alpha-Agonists
    DB00726 antagonist Trimipramine Antidepressants;Adrenergic Uptake Inhibitors;Antidepressive Agents, Tricyclic;Norepinephrine-Reuptake Inhibitors
    DB00734 antagonist Risperidone Antipsychotics;Dopamine Antagonists;Serotonin Antagonists;Antipsychotic Agents
    DB00745 partial agonist Modafinil Central Nervous System Stimulants;Central Nervous System Agents;Anorexigenic Agents;Stimulants;Neuroprotective Agents
    DB00777 antagonist Propiomazine Sedatives and Hypnotics
    DB01142 antagonist Doxepin Antidepressants;Anti-anxiety Agents;Antipruritics;Antidepressive Agents, Tricyclic;Norepinephrine-Reuptake Inhibitors;Histamine Antagonists
    DB01149 other/unknown Nefazodone Antidepressants;Analgesics;Antidepressive Agents, Second-Generation;Serotonin Agents
    DB01162 antagonist Terazosin Antineoplastic Agents;Adrenergic alpha-Antagonists
    DB01186 agonist Pergolide Central Nervous System Agents;Antiparkinson Agents;Antidyskinetics;Dopamine Agonists;Neuroprotective Agents
    DB01200 agonist Bromocriptine Antiparkinson Agents;Antidyskinetics;Dopamine Agonists;Hormone Antagonists
    DB01224 antagonist Quetiapine Antipsychotics;Antipsychotic Agents
    DB01238 other/unknown Aripiprazole Antipsychotics;Antipsychotic Agents
    DB01255 antagonist Lisdexamfetamine Central Nervous System Agents
    DB01267 antagonist Paliperidone Antipsychotic Agents
    DB01403 antagonist Methotrimeprazine Dopamine Antagonists;Analgesics, Non-Narcotic;Antipsychotic Agents
    DB01576 antagonist Adderall XR Adrenergic Agents;Dopamine Agents;Dopamine Uptake Inhibitors;Adrenergic Uptake Inhibitors;Central Nervous System Stimulants;Sympathomimetics
    DB01579 agonist Phendimetrazine Anorexigenic Agents
    DB01608 antagonist Propericiazine Phenothiazines;Antipsychotic Agents
    DB01614 antagonist Acepromazine Dopamine Antagonists;Antipsychotic Agents;Sedatives and Hypnotics
    DB01622 antagonist Thioproperazine Phenothiazines;Antipsychotic Agents
    DB06144 - Sertindole Neuroleptics;Antipsychotic Agents
    DB06262 agonist Droxidopa Vasoconstrictor Agents;Sympathomimetics;Adrenergic alpha-Agonists
    DB06694 agonist Xylometazoline Sympathomimetics;Adrenergic alpha-Agonists;Nasal Decongestants
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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