AutismKB 2.0

Annotation Detail for CST3


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Basic Information Top
Gene Symbol:CST3 ( ARMD11,MGC117328 )
Gene Full Name: cystatin C
Band: 20p11.21
Quick LinksEntrez ID:1471; OMIM: 604312; Uniprot ID:CYTC_HUMAN; ENSEMBL ID: ENSG00000101439; HGNC ID: 2475
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1731Growth retardation
1740Alzheimer's disease
1781Rheumatoid arthritis
1799Epilepsy
1806Arteriopathy
1820Kuhnt-Junius degeneration
1831Prostate cancer
1840Macular degeneration
1848Embryoma
1860Brain tumor
1902Kidney failure
1904Diabetes mellitus
1918Atherosclerosis
1944Breast cancer
1963Amyloidosis
2008Liver disease
2014Pulmonary alveolar proteinosis
2091Hypertension
2085Vascular dementia
2134Amyotrophic lateral sclerosis
2138Osteoporosis
1855Prostatic hypertrophy, Benign
2196Periodontal disease
2237Neoplasm metastasis
2246Malnutrition
Desease Name
Macular Degeneration
Cystatin C
Alzheimer's disease
RENAL
NEUROLOGICAL
VISION
frontotemporal lobar degeneration
Desease Name
Chronic kidney disease
Desease Name
Macular degeneration, age-related, 11
Cerebral amyloid angiopathy
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C422565 13beta-methyl 19-nor-steroid 13beta-methyl 19-nor-steroid inhibits the reaction [IFNE protein promotes the reaction [Progesterone results in increased expression of CST3 mRNA]]decreases reaction|increases expression|increases reaction 16556762
C422565 13beta-methyl 19-nor-steroid 13beta-methyl 19-nor-steroid inhibits the reaction [Progesterone results in increased expression of CST3 mRNA]decreases reaction|increases expression 16556762
C430898 AGN 194204 AGN 194204 results in increased expression of CST3 mRNAincreases expression 16339527
D000643 Ammonium Chloride Ammonium Chloride affects the expression of CST3 mRNAaffects expression 16483693
D001151 Arsenic Arsenic results in increased expression of CST3 mRNAincreases expression 18315880
C006632 arsenic trioxide arsenic trioxide results in decreased expression of CST3 mRNAdecreases expression 15725085
D002251 Carbon Tetrachloride Carbon Tetrachloride results in decreased expression of CST3 mRNAdecreases expression 17484886
D002251 Carbon Tetrachloride Carbon Tetrachloride results in increased expression of CST3 mRNAincreases expression 16239168
D002794 Choline Choline affects the expression of CST3 mRNAaffects expression 17616785
D003024 Clozapine Clozapine results in increased expression of CST3 mRNAincreases expression 14647396
C014347 decitabine [decitabine co-treated with vorinostat] affects the expression of CST3 mRNAaffects cotreatment|affects expression 17330099
D004041 Dietary Fats Dietary Fats results in increased expression of CST3 mRNAincreases expression 15238619
D004997 Ethinyl Estradiol Ethinyl Estradiol results in decreased expression of CST3 mRNAdecreases expression 19400957
D004997 Ethinyl Estradiol Ethinyl Estradiol results in decreased expression of CST3 mRNAdecreases expression 19400957
17557909
D005419 Flavonoids Flavonoids results in increased expression of CST3 mRNAincreases expression 18035473
D006220 Haloperidol Haloperidol results in increased expression of CST3 mRNAincreases expression 14647396
C006253 pirinixic acid pirinixic acid results in increased expression of CST3 mRNAincreases expression 18301758
D011374 Progesterone 13beta-methyl 19-nor-steroid inhibits the reaction [IFNE protein promotes the reaction [Progesterone results in increased expression of CST3 mRNA]]decreases reaction|increases expression|increases reaction 16556762
D011374 Progesterone 13beta-methyl 19-nor-steroid inhibits the reaction [Progesterone results in increased expression of CST3 mRNA]decreases reaction|increases expression 16556762
D011374 Progesterone IFNE protein promotes the reaction [Progesterone results in increased expression of CST3 mRNA]increases expression|increases reaction 16556762
D011374 Progesterone Progesterone results in increased expression of CST3 mRNAincreases expression 16556762
C410733 scriptaid scriptaid affects the expression of CST3 mRNAaffects expression 18813790
D012643 Selenium Selenium results in increased expression of CST3 mRNAincreases expression 19244175
D013629 Tamoxifen Tamoxifen results in decreased expression of CST3 mRNAdecreases expression 19400957
D013629 Tamoxifen Tamoxifen results in decreased expression of CST3 mRNAdecreases expression 19400957
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of CST3 mRNAdecreases expression 16054898
D014810 Vitamin E Vitamin E results in increased expression of CST3 mRNAincreases expression 19244175
C111237 vorinostat [decitabine co-treated with vorinostat] affects the expression of CST3 mRNAaffects cotreatment|affects expression 17330099
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.4414745880
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.7415322242 14514962 11752688
MESH:D000138 Acidosis Ammonium Chloride 3.4518287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.8417505938
MESH:D055371 Acute Lung Injury pirinixic acid 3.0118653653
MESH:D000230 Adenocarcinoma arsenic trioxide 4.2011798837 19825857
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 4.2014692618
MESH:D018248 Adenoma, Liver Cell pirinixic acid 9.5416434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 9.5416835633
MESH:D018246 Adrenocortical Adenoma Arsenic 5.1117306315
MESH:D000380 Agranulocytosis Clozapine 4.9514617031 12649775 16160616
MESH:D000544 Alzheimer Disease marker/mechanism|therapeutic 17192785 18026100
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.8511748828
MESH:D020261 Arsenic Poisoning Arsenic 2.8412569548 16251483 18414634 16835338
MESH:D001161 Arteriosclerosis Dietary Fats 9.5515238619
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 9.5511256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.6015885639
MESH:D050197 Atherosclerosis Arsenic 3.1812928151 19371607
MESH:D001321 Autistic Disorder Choline 2.8316818868
MESH:D001321 Autistic Disorder Haloperidol 2.8319368416 18080171
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 14.6916206674
MESH:D001778 Blood Coagulation Disorders pirinixic acid 14.6919483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 14.6912125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.6915340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.6915746008
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 5.2317868700
MESH:D001930 Brain Injuries Progesterone 4.1515845082 15665606 15380490
MESH:D001943 Breast Neoplasms decitabine 2.9119208741 18320071
MESH:D001943 Breast Neoplasms Dietary Fats 2.9120435547
MESH:D001943 Breast Neoplasms Progesterone 2.9115562024 16175315 17614352
MESH:D001943 Breast Neoplasms Tamoxifen 2.9119011961 21138602 19189210 20065188 19189212 21152245 18815881 17049068 11161223 19487384 20859285 17440819 20544844 19059307 17893378 17261762 20390343 19066611 19084267 19244106 19288272 16818667 15668708 16873071 19115204 19103187 19155303 16273361 20135344 19410462 18629630 19200415 19221464 19289846 15565566 18821012 18351453 18425577 18855134 20005174 17242785 18997820 16202921 18984771 19142967
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.9120435547
MESH:D001943 Breast Neoplasms vorinostat 2.9116144943
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.2211589617
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 9.5715700767 3786805 16227642 10355542 15721981 16097048 15673190 18705752 16011737 16050911 16124888 16192424
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 9.5716050911
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.7116835633
MESH:D002280 Carcinoma, Basal Cell Arsenic 3.5315504454 17687452
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.4019066611
MESH:D006528 Carcinoma, Hepatocellular Arsenic 6.4617306315 16507464
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 6.4616217749 14691202 15553829 11135700 15073043
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 6.4618788625
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 6.4616924424
MESH:D002291 Carcinoma, Papillary arsenic trioxide 4.7719014326
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 4.0212490120
MESH:D002294 Carcinoma, Squamous Cell Arsenic 4.8115504454 17687452 18922899
MESH:D002294 Carcinoma, Squamous Cell decitabine 4.8119215824
MESH:D002295 Carcinoma, Transitional Cell Arsenic 9.1718640142
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 9.1717572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.3118850075 16120746 18670907
MESH:D002318 Cardiovascular Diseases Arsenic 3.3719152805 15738583 17938729
MESH:D002340 Carotid Artery Diseases Arsenic 4.2118022660 16973168
MESH:D002375 Catalepsy Haloperidol 4.8015215559 1977408
MESH:D028243 Cerebral Amyloid Angiopathy, Familial marker/mechanism 18566660
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.0716835633
MESH:D002779 Cholestasis Ethinyl Estradiol 7.4711677210 17110522 17333356 15861022 16105132 16919318 17681005
MESH:D002779 Cholestasis pirinixic acid 7.4719176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.0612621046 8697196 15340226 15668235 16354765
MESH:D003072 Cognition Disorders Clozapine 4.8517123785
MESH:D003092 Colitis Selenium 3.6717936198
MESH:D003110 Colonic Neoplasms decitabine 2.3217616700
MESH:D015179 Colorectal Neoplasms arsenic trioxide 2.5620501625
MESH:D015179 Colorectal Neoplasms decitabine 2.5618981723
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.9617141729 14669216
MESH:D023903 Coronary Restenosis arsenic trioxide 4.0812609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 3.7010525206
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 3.7015322242 20055451 10048152
MESH:D019465 Craniofacial Abnormalities Vitamin E 3.7019769572
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 10.5715213294
MESH:D016757 Death, Sudden, Cardiac Haloperidol 10.5720210726
MESH:D003704 Dementia Haloperidol 4.4811575062
MESH:D003711 Demyelinating Diseases Tamoxifen 4.2519031437
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.3818249437
MESH:D002658 Developmental Disabilities Choline 4.6016818868
MESH:D003924 Diabetes Mellitus, Type 2 Clozapine 4.4216402076
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.4217107852
MESH:D003928 Diabetic Nephropathies Tamoxifen 3.3819279558
MESH:D003929 Diabetic Neuropathies Progesterone 4.3817187935
MESH:D003967 Diarrhea vorinostat 4.3920479100
MESH:D006970 Disorders of Excessive Somnolence Clozapine 5.4515331141
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 6.0116227642 2869522 7440962 10092053 6623471 11566570 17522070 19336974 3786805 15027814 19085960 7179309 10915739 6884620 4309450 3732212 16177239 9327722 15998439 7120509 21278145 15968718
MESH:D056486 Drug-Induced Liver Injury Selenium 6.0115131321
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 6.0120420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.6811462148
MESH:D050171 Dyslipidemias Clozapine 8.6016402076
MESH:D050171 Dyslipidemias Dietary Fats 8.6018367378
MESH:C538011 Eales disease Vitamin E 4.609068938
MESH:D004487 Edema pirinixic acid 6.2012083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 6.2011000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.8016714409 15322242 18230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 14.7012538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 14.7017692515
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 14.7019031437
MESH:D004701 Endocrine Gland Neoplasms decitabine 5.0119294695
MESH:D016889 Endometrial Neoplasms Tamoxifen 2.9716202921 20544844 19155303 17893378
MESH:D004715 Endometriosis Progesterone 8.6016134523
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 8.609294722 10568697
MESH:D004938 Esophageal Neoplasms arsenic trioxide 2.2812903497
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.9311564622
MESH:D005221 Fatigue vorinostat 5.4920479100
MESH:D005234 Fatty Liver arsenic trioxide 29.4015073043
MESH:D005234 Fatty Liver Carbon Tetrachloride 29.4061145 16239168 19224547 16045604 12631006 12795759 15959796 17595544
MESH:D005234 Fatty Liver Dietary Fats 29.4017967931 19551842 19004024 18296743
MESH:D005234 Fatty Liver Ethinyl Estradiol 29.4015345470
MESH:D005234 Fatty Liver pirinixic acid 29.4020131406 19236843
MESH:D005234 Fatty Liver Tamoxifen 29.4014986274 19224547
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.1716709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.3511858732
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.4214745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.0719069698
MESH:D005355 Fibrosis Carbon Tetrachloride 14.1318705752
MESH:D005355 Fibrosis Dietary Fats 14.1318296743
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 14.1320067830
MESH:D005534 Foot Diseases Arsenic 5.456392382
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.1516904648
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.4910696789
MESH:D006258 Head and Neck Neoplasms decitabine 3.4119215824
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.3810048152 11294989
MESH:D006330 Heart Defects, Congenital Vitamin E 6.3816080930
MESH:D006333 Heart Failure pirinixic acid 6.7320558911
MESH:D006333 Heart Failure Selenium 6.7317162251
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.2311000095
MESH:D006505 Hepatitis Carbon Tetrachloride 3.4919900420 19110552
MESH:D006529 Hepatomegaly pirinixic acid 7.9016221962 18467677 19176532 19772884
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 7.9016120746 12621046 15340226
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.6616863852 16490937
MESH:D019584 Hot Flashes Vitamin E 3.8714716179
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.9416959395 18606429 16354765 15340226 8697196
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.4216899240
MESH:D006937 Hypercholesterolemia Dietary Fats 3.4921332399
MESH:D006943 Hyperglycemia pirinixic acid 3.0820558911
MESH:D017488 Hyperkeratosis, Epidermolytic Arsenic 4.3617050553
MESH:D006948 Hyperkinesis Clozapine 4.8016046005
MESH:D006949 Hyperlipidemias Dietary Fats 3.5121332399
MESH:D006973 Hypertension Arsenic 5.099931084 11953799 16076760
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.0918670907 18850075
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 3.9815338365
MESH:D006987 Hypesthesia Arsenic 5.4516093927
MESH:D007021 Hypospadias Ethinyl Estradiol 3.7016945680 16569931
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 4.2915869954
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.3612013081
MESH:D007248 Infertility, Male decitabine 6.4817581917
MESH:D007248 Infertility, Male Ethinyl Estradiol 6.4817937319
MESH:D007249 Inflammation Dietary Fats 15.2620412841
MESH:D007249 Inflammation Flavonoids 15.2617296493
MESH:D007249 Inflammation Progesterone 15.2615869954
MESH:D007249 Inflammation Tamoxifen 15.2619457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 15.2612200463 12878042
MESH:D007251 Influenza, Human Selenium 10.6116624496
MESH:D007251 Influenza, Human Vitamin E 10.6116624496
MESH:D007333 Insulin Resistance Dietary Fats 7.0111836018 18457598
MESH:D007333 Insulin Resistance pirinixic acid 7.0116306350
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.2316580747
MESH:D007642 Keratosis Arsenic 4.8816930632 12749816
MESH:D007674 Kidney Diseases Vitamin E 2.7412488133
MESH:D007676 Kidney Failure, Chronic Selenium 3.7816518626
MESH:D007680 Kidney Neoplasms Tamoxifen 2.9518625569
MESH:D007938 Leukemia arsenic trioxide 6.2715070760
MESH:D007938 Leukemia decitabine 6.2719235587 18980019
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 3.6917077332 12560223
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.2016972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.3514633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 9.2519077051
MESH:D007951 Leukemia, Myeloid decitabine 9.2518454857 17236224 19117987
MESH:D015470 Leukemia, Myeloid, Acute marker/mechanism 17330099
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 3.9220471514 17050201 16467208 16968895 19850784
MESH:D015470 Leukemia, Myeloid, Acute decitabine 3.9219010910 18704418 18460780 18206229 19387464 17679729
MESH:D015477 Leukemia, Myelomonocytic, Chronic decitabine 5.3618055864
MESH:D015473 Leukemia, Promyelocytic, Acute Arsenic 7.5417339181
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 7.5411161223 16330433 15748426 12712474 12679006 17712046 16331271 9834237 17217047 17107899 15336539 16112521 12018890 16891316 15622746 16966277 17869043 19642359 17649720 15213294 19225113 16823087 19075265 19035177 11468182
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.2416882451
MESH:D008064 Lipidoses Clozapine 7.8217567588
MESH:D008064 Lipidoses Tamoxifen 7.8217567588 15342952
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 6.4317157831 11903743 16943688 21278145 16221502 17334410 11408273 17174718 16239168
MESH:D008103 Liver Cirrhosis Dietary Fats 6.4318296743
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 6.5815959796 17869086 15996030 15818738 13678700 16136751 18187930 17557913 18376398 12898905 16011737 12632514 18429990 14748882 16027843 17823541 15876570 18472094 12586293 12666154 12609069 12546737 16033810 15730626 18420326 18277467 12632512 15673190 15123356 16015684 14716833 12649538 16097048 14716496 16192424 18210741 12741479 16248980 12445421 18395914 17525996 18412020 18263696 15338365 18205269 17805973 17900296 17761835 17721639 18472332 18251166 17565644 17714472 18054572 18418968 15931870 18395095 17698563 15362042 16116963 18339082 15057751 18279442 20821823 17640975 15370692 17766677 17922224 12958196 14512876 17631135 18166357 17708605 15893842 15650968 18006644 12667390 18481824 10355542 15925388 18156304 12445418 15052691 11481614 17976157 16638106 17944888 12389079 17481882 18705752 18317297 14724832 14620537
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 6.5815474484
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 6.5818564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 6.5812878042
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 6.5816169303
MESH:D008107 Liver Diseases Arsenic 4.1411134558
MESH:D008107 Liver Diseases Carbon Tetrachloride 4.1416964402 17285989 15830285 15720792 16246199
MESH:D017093 Liver Failure Carbon Tetrachloride 4.0515123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 3.5916899240 14706259
MESH:D008113 Liver Neoplasms Arsenic 17.4516368122
MESH:D008113 Liver Neoplasms arsenic trioxide 17.4514682389
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 17.4519294768
MESH:D008113 Liver Neoplasms pirinixic acid 17.4516377806 15890375 20007298
MESH:D008113 Liver Neoplasms Tamoxifen 17.4516684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 17.4516984957
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 9.4120377131
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 9.4112014681 15583823
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 9.4112151625
MESH:D008133 Long QT Syndrome arsenic trioxide 3.2615213294
MESH:D008171 Lung Diseases Vitamin E 3.1016863852
MESH:D008175 Lung Neoplasms Arsenic 6.4517306315 17976673 19168569
MESH:D008175 Lung Neoplasms arsenic trioxide 6.4511798837 19825857
MESH:D008175 Lung Neoplasms Tamoxifen 6.4518625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 6.4511884234 19555203
MESH:D008175 Lung Neoplasms Vitamin E 6.4511062179
MESH:D008223 Lymphoma decitabine 3.3419470736
MESH:D016410 Lymphoma, T-Cell, Cutaneous vorinostat 5.5820479100
MESH:D008268 Macular Degeneration marker/mechanism
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 3.6519428831
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 9.5917203775 11408345
MESH:D008325 Mammary Neoplasms, Experimental Selenium 9.5915318939
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 9.5916827153 14580682 19196722 11731420 19196723
MESH:D020149 Manganese Poisoning Tamoxifen 4.4419453300
MESH:D008545 Melanoma decitabine 3.3317785578 16505122
MESH:D008545 Melanoma Tamoxifen 3.3312393984 19393235
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.0715990972
MESH:D001523 Mental Disorders Clozapine 8.0016856516
MESH:D001523 Mental Disorders Haloperidol 8.0016856516
MESH:D008654 Mesothelioma Selenium 2.7515107826
MESH:D024821 Metabolic Syndrome X Clozapine 4.3219142101
MESH:D009101 Multiple Myeloma arsenic trioxide 7.1111468182 19549372 15949261 14977855 19417148
MESH:D009101 Multiple Myeloma decitabine 7.1118172295
MESH:D009135 Muscular Diseases pirinixic acid 3.4016239165
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.5718349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 7.2916882451 16105982
MESH:D009190 Myelodysplastic Syndromes decitabine 7.2918608210 16882708 19010910 19157545
MESH:D009203 Myocardial Infarction pirinixic acid 2.1019151258
MESH:D017202 Myocardial Ischemia Arsenic 8.7115371236
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 8.7112213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 2.8616411023
MESH:D009325 Nausea vorinostat 5.4220479100
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 3.8516624393
MESH:D009362 Neoplasm Metastasis Tamoxifen 2.5019393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.4819410462
MESH:D009369 Neoplasms decitabine 4.8419116145 17925555 19470736
MESH:D009369 Neoplasms pirinixic acid 4.8417405874
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 3.8919200415 19189210 19196722
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.1114600291
MESH:D009436 Neural Tube Defects Arsenic 7.2116620997
MESH:D009436 Neural Tube Defects arsenic trioxide 7.2110525206
MESH:D020078 Neurogenic Inflammation Arsenic 4.2717056641
MESH:D009765 Obesity Clozapine 7.3119142110 18515891
MESH:D009765 Obesity Dietary Fats 7.3121332399 20132043 18674790 20518802 17217161 18457598 19632207 16723640 11836018
MESH:D009765 Obesity pirinixic acid 7.3120558911
MESH:D009914 Oral Submucous Fibrosis marker/mechanism 16311067
MESH:D010051 Ovarian Neoplasms Arsenic 11.0517306315
MESH:D010051 Ovarian Neoplasms arsenic trioxide 11.0516624393 19769630 12452020
MESH:D010051 Ovarian Neoplasms decitabine 11.0519331143 19259094
MESH:D010051 Ovarian Neoplasms Progesterone 11.0517393432 16525653
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 5.2715580305
MESH:D010190 Pancreatic Neoplasms decitabine 5.2719294695
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.5811578682
MESH:D010235 Paraganglioma arsenic trioxide 4.0619927285
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.1412520081
MESH:D010523 Peripheral Nervous System Diseases Arsenic 4.0716093927
MESH:D016491 Peripheral Vascular Diseases Arsenic 4.8816905509 6392382 15371236
MESH:D010954 Plasmacytoma Selenium 4.7815087411
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.4518163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.0811896295 11222880 11118676 11399792
MESH:D055728 Primary Myelofibrosis decitabine 4.6217616702
MESH:D011471 Prostatic Neoplasms AGN 194204 1.9016000583
MESH:D011471 Prostatic Neoplasms Arsenic 1.9016140617
MESH:D011471 Prostatic Neoplasms arsenic trioxide 1.9019131511
MESH:D011471 Prostatic Neoplasms Tamoxifen 1.9015067354
MESH:D011471 Prostatic Neoplasms Vitamin E 1.9015084515
MESH:D011471 Prostatic Neoplasms vorinostat 1.9017218635
MESH:D011507 Proteinuria Arsenic 3.9021343184
MESH:D011537 Pruritus Ethinyl Estradiol 3.2016919318 15861022
MESH:D011595 Psychomotor Agitation Haloperidol 4.8511575062
MESH:D011618 Psychotic Disorders Clozapine 8.8915331141
MESH:D011618 Psychotic Disorders Haloperidol 8.8911575062
MESH:D015427 Reperfusion Injury pirinixic acid 2.3319058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.7318990726
MESH:D012208 Rhabdomyosarcoma decitabine 4.3019155313
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.8218045962
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 3.8516646077
MESH:D012559 Schizophrenia Clozapine 4.0411763009 18806925 16141801 20168265 18855531 11151749 17726453 20521320 20452607 19369910 20107430 17667964 20521326 17123785 20580759
MESH:D012559 Schizophrenia Haloperidol 4.0419369910 18513383 1830565 20107430
MESH:D012871 Skin Diseases Arsenic 4.9417453740 6392382 17938729 18709164 16759981 15952646 17548696 17050553 16702368 16353154 19834688
MESH:D012871 Skin Diseases Vitamin E 4.9418709164
MESH:D012878 Skin Neoplasms Arsenic 5.5415504454 17050553 19538983 16251483 17976673 17029826
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.5416192470
MESH:D013088 Spermatocele Ethinyl Estradiol 11.2116709447
MESH:D013088 Spermatocele Tamoxifen 11.2116709447
MESH:D013119 Spinal Cord Injuries Progesterone 10.5116503802 15862959
MESH:D013119 Spinal Cord Injuries Tamoxifen 10.5119457130
MESH:D013274 Stomach Neoplasms arsenic trioxide 2.5417007042
MESH:D013274 Stomach Neoplasms decitabine 2.5419037991
MESH:D020521 Stroke Vitamin E 3.4316517955
MESH:D017180 Tachycardia, Ventricular Haloperidol 4.6020210726
MESH:D013921 Thrombocytopenia vorinostat 4.8720479100
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.5211994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.0615669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.8012697716
MESH:D013964 Thyroid Neoplasms arsenic trioxide 7.0419014326
MESH:D013964 Thyroid Neoplasms decitabine 7.0417967635
MESH:D016171 Torsades de Pointes arsenic trioxide 3.8515213294
MESH:D001749 Urinary Bladder Neoplasms Arsenic 11.6217306315 19429237 15987713 18640142 11144890 17976673 19322015
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 11.6220435036 12845720 11780464 12973940
MESH:D001749 Urinary Bladder Neoplasms decitabine 11.6217616700 19087683
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 11.628653321 17572228 16712894
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.1914692618
MESH:D014604 Uveal Neoplasms decitabine 4.8117785578
MESH:D014652 Vascular Diseases Arsenic 4.6317056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.4912125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.4414671159 15869587
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.1415886252
MESH:D015430 Weight Gain Clozapine 9.5116141801 20107430 20521320 16402076 17502770 20564506
MESH:D015430 Weight Gain Dietary Fats 9.5116723640
MESH:D015431 Weight Loss Clozapine 4.9717933447
Pathway ID Pathway Name
KEGG:04970 Salivary secretion
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA26976
    • No data
    Releated disease ID Related disease Name
    PA443937Drug Toxicity
    PA444071Epilepsy, Temporal Lobe
    PA443797Coronary Disease
    PA446438Kidney Failure
    PA443319Alzheimer Disease
    PA443671Brain Ischemia
    PA443425Arteriosclerosis
    PA443626Carcinoma, Squamous Cell
    No data
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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