AutismKB 2.0

Annotation Detail for APCDD1


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Basic Information Top
Gene Symbol:APCDD1 ( B7323,DRAPC1 )
Gene Full Name: adenomatosis polyposis coli down-regulated 1
Band: 18p11.22
Quick LinksEntrez ID:147495; OMIM: 607479; Uniprot ID:APCD1_HUMAN; ENSEMBL ID: ENSG00000154856; HGNC ID: 15718
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C548651 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in decreased expression of APCDD1 mRNAdecreases expression 19933214
C010914 2,4-diaminotoluene 2,4-diaminotoluene results in increased expression of APCDD1 mRNAincreases expression 20713471
D000082 Acetaminophen Acetaminophen affects the expression of APCDD1 mRNAaffects expression 17562736
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide affects the expression of APCDD1 mRNAaffects expression 20382639
D002251 Carbon Tetrachloride Carbon Tetrachloride results in increased expression of APCDD1 mRNAincreases expression 17484886
D003907 Dexamethasone [Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of APCDD1 mRNAaffects cotreatment|increases expression 16054899
D004041 Dietary Fats Dietary Fats results in decreased expression of APCDD1 mRNAdecreases expression 18457598
18042831
D002117 Calcitriol Calcitriol results in decreased expression of APCDD1 mRNAdecreases expression 16002434
D004958 Estradiol Estradiol results in decreased expression of APCDD1 mRNAdecreases expression 14664709
D015056 1-Methyl-3-isobutylxanthine [Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of APCDD1 mRNAaffects cotreatment|increases expression 16054899
D008748 Methylcholanthrene Methylcholanthrene results in increased expression of APCDD1 mRNAincreases expression 20713471
C041786 palm oil palm oil results in decreased expression of APCDD1 mRNAdecreases expression 18042831
C089730 rosiglitazone [Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of APCDD1 mRNAaffects cotreatment|increases expression 16054899
D018038 Sodium Selenite Sodium Selenite results in decreased expression of APCDD1 mRNAdecreases expression 18175754
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with EGF protein] results in decreased expression of APCDD1 mRNAaffects cotreatment|decreases expression 16054899
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of APCDD1 mRNAdecreases expression 16054899
19933214
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.9015322242 14514962 11752688
MESH:D000230 Adenocarcinoma Estradiol 2.1011473722
MESH:D000236 Adenoma Methylcholanthrene 3.5110545420 6695378
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.4316835633
MESH:D000544 Alzheimer Disease rosiglitazone 2.8619621015
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.9711748828
MESH:D000799 Angioedema Acetaminophen 3.9110982225
MESH:D001161 Arteriosclerosis Dietary Fats 3.9315238619
MESH:D001169 Arthritis, Experimental Dexamethasone 3.5517659584
MESH:D050197 Atherosclerosis Methylcholanthrene 3.4711922910
MESH:D001321 Autistic Disorder Acetaminophen 1.4218445737
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.0712125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.8515340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.7815746008
MESH:D001943 Breast Neoplasms 2,4-diaminotoluene 2.9811921183
MESH:D001943 Breast Neoplasms Calcitriol 2.9811237771
MESH:D001943 Breast Neoplasms Dietary Fats 2.9820435547
MESH:D001943 Breast Neoplasms Estradiol 2.9817261762 12948864 19861407 16675129 17289903 17018787 18497071 14630087
MESH:D001943 Breast Neoplasms Methylcholanthrene 2.9817474063
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.9820435547
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.5116111702
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.8216050911 16124888 15673190 16097048 3786805 16011737 10355542 16227642 18705752 16192424 15700767 15721981
MESH:D002277 Carcinoma Methylcholanthrene 8.4110545420
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 8.4116835633
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 4.543084413
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 4.5418788625
MESH:D006528 Carcinoma, Hepatocellular Estradiol 4.5416924424
MESH:D002294 Carcinoma, Squamous Cell Calcitriol 2.6311237771
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.3818850075 18670907 16120746
MESH:D002386 Cataract Acetaminophen 2.6010977129
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 11.3820889678
MESH:D002471 Cell Transformation, Neoplastic Estradiol 11.3818566989
MESH:D002471 Cell Transformation, Neoplastic Methylcholanthrene 11.3816192471
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.1916835633
MESH:D019457 Chromosome Breakage Sodium Selenite 4.7915894690
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1112621046 8697196 15668235 16354765 15340226
MESH:D003110 Colonic Neoplasms Dexamethasone 2.5015824018
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.0817141729 14669216
MESH:D019465 Craniofacial Abnormalities Dexamethasone 2.6217728286
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.6215322242 20055451 10048152
MESH:D017449 Dermatitis, Allergic Contact Dexamethasone 3.4512438553
MESH:D003920 Diabetes Mellitus rosiglitazone 9.5117446233
MESH:D003920 Diabetes Mellitus Sodium Selenite 9.5116285004
MESH:D003924 Diabetes Mellitus, Type 2 rosiglitazone 4.5212642470
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.5217107852
MESH:D003928 Diabetic Nephropathies Estradiol 3.4419279558
MESH:D003967 Diarrhea Dexamethasone 3.737237001
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 9.0316081117 19420014 12705907 15968718 12958197 17562736 19085960 19164858 16177239 16393943 14725611 12392966 16781746 16485898 17522070 19370779 16109766 10774834 11421492 11743745 11834606 17906064 16227642 11739529 18071297 15619225 11461765 14550746 14986274 11287661 19416960 19739265 10915739 12153990 10663392 19923254 12540782 12594235 11529661 2444490 18713872
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 9.0316177239 6884620 19085960 9327722 15968718 3732212 10915739 19336974 7440962 10092053 15027814 3786805 2869522 16227642 21278145 4309450 7179309 15998439 11566570 7120509 17522070 6623471
MESH:D056486 Drug-Induced Liver Injury Sodium Selenite 9.0315131321
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 9.0320420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.1619426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.7811462148
MESH:D050171 Dyslipidemias Dietary Fats 3.4718367378
MESH:D004485 Eczema Dexamethasone 4.5012438553
MESH:D004487 Edema Dexamethasone 11.7719703484
MESH:D004487 Edema rosiglitazone 11.7712083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 11.7711000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.9616714409 15322242 18230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Calcitriol 3.9715138306
MESH:D016889 Endometrial Neoplasms Estradiol 3.0011473722 18566989 19148513
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.0510568697 9294722
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.0820426865
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.0311564622
MESH:D005234 Fatty Liver Carbon Tetrachloride 13.4315959796 12631006 17595544 16045604 16239168 12795759 19224547 61145
MESH:D005234 Fatty Liver Dietary Fats 13.4317967931 18296743 19004024 19551842
MESH:D005234 Fatty Liver rosiglitazone 13.4319196556
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.5011858732
MESH:D005354 Fibrosarcoma Methylcholanthrene 4.9910962813 14633661
MESH:D005355 Fibrosis Carbon Tetrachloride 15.0218705752
MESH:D005355 Fibrosis Dietary Fats 15.0218296743
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 15.0220067830
MESH:D005756 Gastritis Acetaminophen 3.7416983495
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.6610696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.3410048152 11294989
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.3611000095
MESH:D006505 Hepatitis Carbon Tetrachloride 3.6319900420 19110552
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 2.9315340226 16120746 12621046
MESH:D006548 Hernia, Diaphragmatic Dexamethasone 3.087520565
MESH:D006558 Herpes Genitalis Estradiol 5.0915709030
MESH:D019584 Hot Flashes Estradiol 3.8117088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.1116959395 18606429 16354765 15340226 8697196
MESH:D006930 Hyperalgesia Acetaminophen 7.9616870215
MESH:D006930 Hyperalgesia rosiglitazone 7.9612083418
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.5816899240
MESH:D006937 Hypercholesterolemia Dietary Fats 3.6221332399
MESH:D006949 Hyperlipidemias Dietary Fats 3.6521332399
MESH:D006973 Hypertension Dexamethasone 5.2817042910
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.2818670907 18850075
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.1315338365
OMIM:605389 HYPOTRICHOSIS SIMPLEX, GENERALIZED, HEREDITARY marker/mechanism 20393562
MESH:D007077 Ileal Diseases 1-Methyl-3-isobutylxanthine 5.5118306037
MESH:D007249 Inflammation Dexamethasone 12.138960868 11099482
MESH:D007249 Inflammation Dietary Fats 12.1320412841
MESH:D007249 Inflammation rosiglitazone 12.1312083418
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 12.1312878042 12200463
MESH:D007333 Insulin Resistance Dietary Fats 17.8518457598 11836018
MESH:D007333 Insulin Resistance Estradiol 17.8516393666 16627594
MESH:D007333 Insulin Resistance rosiglitazone 17.8516306350
MESH:D007333 Insulin Resistance Sodium Selenite 17.8514714311
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.3616580747
MESH:D007579 Jejunal Diseases 1-Methyl-3-isobutylxanthine 5.5118306037
MESH:D007674 Kidney Diseases Acetaminophen 5.9415629191 12587719
MESH:D007674 Kidney Diseases Estradiol 5.9415618244
MESH:D007680 Kidney Neoplasms Estradiol 3.0015610895
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 6.6811903743 21278145 17157831 17334410 16943688 17174718 16239168 11408273 16221502
MESH:D008103 Liver Cirrhosis Dietary Fats 6.6818296743
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 6.7918429990 12586293 18156304 15730626 18705752 12632512 15057751 18210741 11481614 16248980 18279442 17557913 10355542 17922224 17721639 17766677 20821823 18187930 13678700 12741479 18205269 15818738 16097048 15338365 17900296 17708605 18481824 17631135 15996030 16638106 18166357 18339082 18420326 17714472 16033810 17481882 12609069 17805973 18395095 16192424 17525996 18251166 12667390 18412020 18418968 18376398 15876570 12898905 14716833 12632514 14724832 15123356 17640975 15931870 12445421 12958196 16027843 17761835 15052691 18395914 17944888 15673190 18006644 15362042 14748882 12546737 18054572 18277467 16136751 16015684 18317297 15893842 16116963 15925388 15650968 14620537 14716496 17823541 17869086 15959796 18472332 16011737 17565644 12445418 17698563 18472094 12649538 18263696 14512876 15370692 12666154 17976157 12389079
MESH:D008106 Liver Cirrhosis, Experimental Dexamethasone 6.7916718785
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 6.7914659978 14716833
MESH:D008106 Liver Cirrhosis, Experimental rosiglitazone 6.7915980055 17347453
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 6.7912878042
MESH:D008107 Liver Diseases Acetaminophen 3.9219014921 11587558 19460945 16610002 12969438 12587719 16611625 19784758
MESH:D008107 Liver Diseases Carbon Tetrachloride 3.9217285989 16246199 15830285 16964402 15720792
MESH:D017093 Liver Failure Carbon Tetrachloride 4.2115123358
MESH:D017114 Liver Failure, Acute Acetaminophen 9.5017185352 16871587
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 9.5016899240 14706259
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 4.4319294768
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 4.4316984957
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 9.9815583823 12014681
MESH:D008114 Liver Neoplasms, Experimental Methylcholanthrene 9.98598648 1399818
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 9.9812151625
MESH:D008175 Lung Neoplasms Dexamethasone 3.5415824018 11195469
MESH:D008175 Lung Neoplasms Methylcholanthrene 3.547750092 10545420 9230183 20512841 16271038 21163286 1399818 6695378 20970405 17909032 16337739 15390079 11893704
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.5419555203 11884234
MESH:D016393 Lymphoma, B-Cell Sodium Selenite 4.0914737004
MESH:D008325 Mammary Neoplasms, Experimental 2,4-diaminotoluene 10.2811921183
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 10.2816891317 11408345 17203775 11807958
MESH:D008325 Mammary Neoplasms, Experimental rosiglitazone 10.2816827153
MESH:D020149 Manganese Poisoning Estradiol 4.5519453300
MESH:D008546 Melanoma, Experimental Acetaminophen 3.6119513568
MESH:D024821 Metabolic Syndrome X rosiglitazone 4.4017261469
MESH:D009101 Multiple Myeloma Dexamethasone 3.5215867202 16118317 15744524
MESH:D009190 Myelodysplastic Syndromes Dexamethasone 3.569809623
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.0412213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 3.3016810080
MESH:D009389 Neovascularization, Pathologic Estradiol 3.7817289903
MESH:D009421 Nervous System Malformations Estradiol 9.5911399458 16427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 9.5914600291
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.8918514411
MESH:D009765 Obesity Dietary Fats 2.2920132043 19632207 18674790 21332399 11836018 20518802 16723640 17217161 18457598
MESH:D010051 Ovarian Neoplasms Estradiol 2.2319401270
MESH:D010146 Pain Acetaminophen 2.4116870215
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.3112520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.5918163543
MESH:D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma Dexamethasone 3.5621297632
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.2411399792 11896295 11222880 11118676
MESH:D011470 Prostatic Hyperplasia Calcitriol 4.8315572423
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.9120887781
MESH:D011471 Prostatic Neoplasms Calcitriol 2.6115754350 18247401 16289102 12479363 16644109
MESH:D011471 Prostatic Neoplasms Estradiol 2.6116740699
MESH:D011471 Prostatic Neoplasms Sodium Selenite 2.6118760546
MESH:D012128 Respiratory Distress Syndrome, Adult Dexamethasone 4.0518379247 11700416
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.8718990726
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.0516192470
MESH:D013272 Stomach Diseases Dexamethasone 4.3715472012
MESH:D013276 Stomach Ulcer Dexamethasone 3.5115138204
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.9612697716
MESH:D013978 Tibial Fractures Estradiol 4.7519048282
MESH:D014581 Urticaria Acetaminophen 3.0110982225
MESH:D014605 Uveitis Dexamethasone 4.881336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.6612125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.3115886252
MESH:D015430 Weight Gain Dietary Fats 3.7616723640
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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