AutismKB 2.0

Annotation Detail for ADRA1A


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Basic Information Top
Gene Symbol:ADRA1A ( ADRA1C,ADRA1L1,ALPHA1AAR )
Gene Full Name: adrenergic, alpha-1A-, receptor
Band: 8p21.2
Quick LinksEntrez ID:148; OMIM: 104221; Uniprot ID:ADA1A_HUMAN; ENSEMBL ID: ENSG00000120907; HGNC ID: 277
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04270Vascular smooth muscle contraction
hsa04080Neuroactive ligand-receptor interaction
hsa04020Calcium signaling pathway
hsa04970Salivary secretion
Pathway IDPathway Name
Signaling by GPCR
No data
Pathway IDPathway Name
P00026Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
P00002Alpha adrenergic receptor signaling pathway
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1831Prostate cancer
1902Kidney failure
2091Hypertension
Desease Name
CARDIOVASCULAR
PSYCH
schizoaffective disorder
hypertension
schizophrenia
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C099060 1-(2-(3-methoxyphenyl)ethyl)phenoxy-3-(dimethylamino)-2-propanol 1-(2-(3-methoxyphenyl)ethyl)phenoxy-3-(dimethylamino)-2-propanol inhibits the reaction [Prazosin binds to ADRA1A protein]affects binding|decreases reaction 11937776
C070379 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [[cirazoline results in increased activity of ADRA1A protein] which results in increased transport of Glucose]decreases reaction|increases activity|increases transport 15550506
C060229 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [[cirazoline results in increased activity of ADRA1A protein] which results in increased transport of Glucose]decreases reaction|increases activity|increases transport 15550506
C010654 (2-(2',6'-dimethoxy)phenoxyethylamino)methylbenzo-1,4-dioxane (2-(2',6'-dimethoxy)phenoxyethylamino)methylbenzo-1,4-dioxane results in decreased activity of ADRA1A proteindecreases activity 11306708
C085911 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[cirazoline results in increased activity of ADRA1A protein] which results in increased transport of Glucose]decreases reaction|increases activity|increases transport 15550506
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in decreased expression of ADRA1A mRNAdecreases expression 18648102
C090942 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [[cirazoline results in increased activity of ADRA1A protein] which results in increased transport of Glucose]decreases reaction|increases activity|increases transport 15550506
C057446 5-methylurapidil 5-methylurapidil inhibits the reaction [[Phenylephrine results in increased activity of ADRA1A protein] which results in increased abundance of Calcium]decreases reaction|increases abundance|increases activity 16498073
C057446 5-methylurapidil 5-methylurapidil results in decreased activity of ADRA1A proteindecreases activity 16498073
C057446 5-methylurapidil 5-methylurapidil inhibits the reaction [ADRA1A protein results in increased susceptibility to Phenylephrine]decreases reaction|increases response to substance 18604236
C057446 5-methylurapidil 5-methylurapidil binds to and results in decreased activity of ADRA1A proteinaffects binding|decreases activity 19566752
15951348
15872040
C057446 5-methylurapidil 5-methylurapidil results in decreased activity of ADRA1A proteindecreases activity 11306708
C094643 A 61603 A 61603 results in increased activity of ADRA1A proteinincreases activity 16498073
C094643 A 61603 [A 61603 results in increased activity of ADRA1A protein] which results in increased abundance of Calciumincreases abundance|increases activity 16498073
C094643 A 61603 A 61603 binds to and results in increased activity of ADRA1A proteinaffects binding|increases activity 15872040
15877108
C094643 A 61603 ADRA1A protein results in increased susceptibility to A 61603increases response to substance 15877108
D000643 Ammonium Chloride Ammonium Chloride affects the expression of ADRA1A mRNAaffects expression 16483693
D001464 Barium ADRA1A protein promotes the reaction [TRPC6 protein results in increased transport of Barium]increases reaction|increases transport 11179201
C053428 BMY 7378 BMY 7378 binds to [ADRA1A protein binds to ADRA1D protein]affects binding 16195468
D002118 Calcium 5-methylurapidil inhibits the reaction [[Phenylephrine results in increased activity of ADRA1A protein] which results in increased abundance of Calcium]decreases reaction|increases abundance|increases activity 16498073
D002118 Calcium [A 61603 results in increased activity of ADRA1A protein] which results in increased abundance of Calciumincreases abundance|increases activity 16498073
D002118 Calcium [Phenylephrine results in increased activity of ADRA1A protein] which results in increased abundance of Calciumincreases abundance|increases activity 16498073
D002118 Calcium ADRA1A protein affects the transport of Calciumaffects transport 15639650
D002118 Calcium Calcium affects the reaction [[Phenylephrine results in increased activity of ADRA1A protein] which results in increased phosphorylation of EIF4EBP1 protein]affects reaction|increases activity|increases phosphorylation 12935885
D002118 Calcium Calcium affects the reaction [[Phenylephrine results in increased activity of ADRA1A protein] which results in increased phosphorylation of MTOR protein]affects reaction|increases activity|increases phosphorylation 12935885
D002118 Calcium Calcium affects the reaction [[Phenylephrine results in increased activity of ADRA1A protein] which results in increased phosphorylation of RPS6KB1 protein]affects reaction|increases activity|increases phosphorylation 12935885
D002118 Calcium [Epinephrine binds to and results in increased activity of ADRA1A protein] which results in increased transport of Calciumaffects binding|increases activity|increases transport 15672411
D002118 Calcium [Phenylephrine binds to and results in increased activity of ADRA1A protein] which results in increased transport of Calciumaffects binding|increases activity|increases transport 15672411
D004390 Chlorpyrifos Chlorpyrifos affects the expression of ADRA1A mRNAaffects expression 18812211
D004390 Chlorpyrifos Chlorpyrifos results in decreased expression of ADRA1A mRNAdecreases expression 17452286
C014282 cirazoline 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [[cirazoline results in increased activity of ADRA1A protein] which results in increased transport of Glucose]decreases reaction|increases activity|increases transport 15550506
C014282 cirazoline 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [[cirazoline results in increased activity of ADRA1A protein] which results in increased transport of Glucose]decreases reaction|increases activity|increases transport 15550506
C014282 cirazoline 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[cirazoline results in increased activity of ADRA1A protein] which results in increased transport of Glucose]decreases reaction|increases activity|increases transport 15550506
C014282 cirazoline 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [[cirazoline results in increased activity of ADRA1A protein] which results in increased transport of Glucose]decreases reaction|increases activity|increases transport 15550506
C014282 cirazoline ADRA1A protein promotes the reaction [cirazoline results in increased expression of NPPA protein]increases expression|increases reaction 18378355
C014282 cirazoline cirazoline binds to and results in increased activity of ADRA1A proteinaffects binding|increases activity 15550506
C014282 cirazoline [cirazoline results in increased activity of ADRA1A protein] which results in increased transport of Glucoseincreases activity|increases transport 15550506
C014282 cirazoline Go 6983 inhibits the reaction [[cirazoline results in increased activity of ADRA1A protein] which results in increased transport of Glucose]decreases reaction|increases activity|increases transport 15550506
C014282 cirazoline Prazosin inhibits the reaction [[cirazoline results in increased activity of ADRA1A protein] which results in increased transport of Glucose]decreases reaction|increases activity|increases transport 15550506
D016572 Cyclosporine Cyclosporine results in decreased expression of ADRA1A mRNAdecreases expression 20106945
D003976 Diazinon Diazinon results in decreased expression of ADRA1A mRNAdecreases expression 17452286
D003993 Dibutyl Phthalate Dibutyl Phthalate results in decreased expression of ADRA1A mRNAdecreases expression 15620428
D004051 Diethylhexyl Phthalate Diethylhexyl Phthalate results in decreased expression of ADRA1A mRNAdecreases expression 15620428
D017292 Doxazosin Doxazosin binds to and results in decreased activity of ADRA1A proteinaffects binding|decreases activity 16007219
D004837 Epinephrine Epinephrine binds to and results in increased activity of ADRA1A proteinaffects binding|increases activity 15672411
D004837 Epinephrine [Epinephrine binds to and results in increased activity of ADRA1A protein] which results in increased transport of Calciumaffects binding|increases activity|increases transport 15672411
D000431 Ethanol Ethanol inhibits the reaction [[Phenylephrine results in increased activity of ADRA1A protein] which results in increased phosphorylation of EIF4EBP1 protein]decreases reaction|increases activity|increases phosphorylation 12935885
D000431 Ethanol Ethanol inhibits the reaction [[Phenylephrine results in increased activity of ADRA1A protein] which results in increased phosphorylation of MTOR protein]decreases reaction|increases activity|increases phosphorylation 12935885
D000431 Ethanol Ethanol inhibits the reaction [[Phenylephrine results in increased activity of ADRA1A protein] which results in increased phosphorylation of RPS6KB1 protein]decreases reaction|increases activity|increases phosphorylation 12935885
D005576 Forskolin [Forskolin co-treated with 1-Methyl-3-isobutylxanthine] affects the reaction [[Phenylephrine binds to and results in increased activity of ADRA1A protein] which affects the transport of Potassium]affects binding|affects cotreatment|affects reaction|affects transport|increases activity 19419905
D005947 Glucose 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [[cirazoline results in increased activity of ADRA1A protein] which results in increased transport of Glucose]decreases reaction|increases activity|increases transport 15550506
D005947 Glucose 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [[cirazoline results in increased activity of ADRA1A protein] which results in increased transport of Glucose]decreases reaction|increases activity|increases transport 15550506
D005947 Glucose 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[cirazoline results in increased activity of ADRA1A protein] which results in increased transport of Glucose]decreases reaction|increases activity|increases transport 15550506
D005947 Glucose 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [[cirazoline results in increased activity of ADRA1A protein] which results in increased transport of Glucose]decreases reaction|increases activity|increases transport 15550506
D005947 Glucose [cirazoline results in increased activity of ADRA1A protein] which results in increased transport of Glucoseincreases activity|increases transport 15550506
D005947 Glucose Go 6983 inhibits the reaction [[cirazoline results in increased activity of ADRA1A protein] which results in increased transport of Glucose]decreases reaction|increases activity|increases transport 15550506
D005947 Glucose [Phenylephrine results in increased activity of ADRA1A protein] which results in increased transport of Glucoseincreases activity|increases transport 15550506
D005947 Glucose Prazosin inhibits the reaction [[cirazoline results in increased activity of ADRA1A protein] which results in increased transport of Glucose]decreases reaction|increases activity|increases transport 15550506
C487498 Go 6983 Go 6983 inhibits the reaction [[cirazoline results in increased activity of ADRA1A protein] which results in increased transport of Glucose]decreases reaction|increases activity|increases transport 15550506
D015056 1-Methyl-3-isobutylxanthine [Forskolin co-treated with 1-Methyl-3-isobutylxanthine] affects the reaction [[Phenylephrine binds to and results in increased activity of ADRA1A protein] which affects the transport of Potassium]affects binding|affects cotreatment|affects reaction|affects transport|increases activity 19419905
D007650 Ketanserin Ketanserin inhibits the reaction [Prazosin binds to ADRA1A protein]affects binding|decreases reaction 11937776
C095285 KMD 3213 KMD 3213 binds to and results in decreased activity of ADRA1A proteinaffects binding|decreases activity 19371927
C095285 KMD 3213 KMD 3213 inhibits the reaction [Phenylephrine binds to and results in increased activity of ADRA1A protein]affects binding|decreases reaction|increases activity 19371927
C057416 KT 5720 KT 5720 inhibits the reaction [[Phenylephrine results in increased activity of ADRA1A protein] which results in decreased transport of Potassium]decreases reaction|decreases transport|increases activity 15365637
C108255 levormeloxifene levormeloxifene results in decreased expression of ADRA1A mRNAdecreases expression 20201831
D009151 Mustard Gas Mustard Gas results in increased expression of ADRA1A mRNAincreases expression 15674844
D009638 Norepinephrine ADRA1A protein affects the susceptibility to Norepinephrineaffects response to substance 12417256
D009638 Norepinephrine Norepinephrine affects the expression of ADRA1A proteinaffects expression 12417256
D010100 Oxygen Oxygen deficiency results in increased expression of ADRA1A mRNAincreases expression 18084315
D010109 Oxymetazoline Oxymetazoline binds to and results in increased activity of ADRA1A proteinaffects binding|increases activity 15872040
D010269 Paraquat Paraquat results in decreased expression of ADRA1A mRNAdecreases expression 17077588
D010656 Phenylephrine KMD 3213 inhibits the reaction [Phenylephrine binds to and results in increased activity of ADRA1A protein]affects binding|decreases reaction|increases activity 19371927
D010656 Phenylephrine Phenylephrine binds to and results in increased activity of ADRA1A proteinaffects binding|increases activity 19371927
D010656 Phenylephrine 5-methylurapidil inhibits the reaction [[Phenylephrine results in increased activity of ADRA1A protein] which results in increased abundance of Calcium]decreases reaction|increases abundance|increases activity 16498073
D010656 Phenylephrine ADRA1A protein affects the susceptibility to Phenylephrineaffects response to substance 18257748
D010656 Phenylephrine [Forskolin co-treated with 1-Methyl-3-isobutylxanthine] affects the reaction [[Phenylephrine binds to and results in increased activity of ADRA1A protein] which affects the transport of Potassium]affects binding|affects cotreatment|affects reaction|affects transport|increases activity 19419905
D010656 Phenylephrine [KCND3 protein co-treated with ADRA1A protein] affects the susceptibility to Phenylephrineaffects cotreatment|affects response to substance 11709419
D010656 Phenylephrine KT 5720 inhibits the reaction [[Phenylephrine results in increased activity of ADRA1A protein] which results in decreased transport of Potassium]decreases reaction|decreases transport|increases activity 15365637
D010656 Phenylephrine Phenylephrine binds to and results in increased activity of ADRA1A proteinaffects binding|increases activity 19419905
D010656 Phenylephrine [Phenylephrine binds to and results in increased activity of ADRA1A protein] which affects the abundance of Phosphatidylinositol 4,5-Diphosphateaffects abundance|affects binding|increases activity 19419905
D010656 Phenylephrine [Phenylephrine binds to and results in increased activity of ADRA1A protein] which affects the transport of Potassiumaffects binding|affects transport|increases activity 19419905
D010656 Phenylephrine Phenylephrine results in decreased activity of [KCND3 protein alternative form co-treated with ADRA1A protein]affects cotreatment|decreases activity 11709419
D010656 Phenylephrine Phenylephrine results in increased activity of ADRA1A proteinincreases activity 15365637
16498073
D010656 Phenylephrine [Phenylephrine results in increased activity of ADRA1A protein] which affects the transport of Potassiumaffects transport|increases activity 15365637
D010656 Phenylephrine [Phenylephrine results in increased activity of ADRA1A protein] which results in increased abundance of Calciumincreases abundance|increases activity 16498073
D010656 Phenylephrine Prazosin inhibits the reaction [[Phenylephrine results in increased activity of ADRA1A protein] which results in decreased transport of Potassium]decreases reaction|decreases transport|increases activity 15365637
D010656 Phenylephrine Ro 32-0432 inhibits the reaction [[Phenylephrine results in increased activity of ADRA1A protein] which results in decreased transport of Potassium]decreases reaction|decreases transport|increases activity 15365637
D010656 Phenylephrine 5-methylurapidil inhibits the reaction [ADRA1A protein results in increased susceptibility to Phenylephrine]decreases reaction|increases response to substance 18604236
D010656 Phenylephrine ADRA1A protein results in increased susceptibility to Phenylephrineincreases response to substance 18604236
D010656 Phenylephrine Phenylephrine results in increased expression of ADRA1A mRNAincreases expression 17122163
D010656 Phenylephrine ADRA1A protein results in increased susceptibility to Phenylephrineincreases response to substance 19566752
D010656 Phenylephrine Calcium affects the reaction [[Phenylephrine results in increased activity of ADRA1A protein] which results in increased phosphorylation of EIF4EBP1 protein]affects reaction|increases activity|increases phosphorylation 12935885
D010656 Phenylephrine Calcium affects the reaction [[Phenylephrine results in increased activity of ADRA1A protein] which results in increased phosphorylation of MTOR protein]affects reaction|increases activity|increases phosphorylation 12935885
D010656 Phenylephrine Calcium affects the reaction [[Phenylephrine results in increased activity of ADRA1A protein] which results in increased phosphorylation of RPS6KB1 protein]affects reaction|increases activity|increases phosphorylation 12935885
D010656 Phenylephrine Ethanol inhibits the reaction [[Phenylephrine results in increased activity of ADRA1A protein] which results in increased phosphorylation of EIF4EBP1 protein]decreases reaction|increases activity|increases phosphorylation 12935885
D010656 Phenylephrine Ethanol inhibits the reaction [[Phenylephrine results in increased activity of ADRA1A protein] which results in increased phosphorylation of MTOR protein]decreases reaction|increases activity|increases phosphorylation 12935885
D010656 Phenylephrine Ethanol inhibits the reaction [[Phenylephrine results in increased activity of ADRA1A protein] which results in increased phosphorylation of RPS6KB1 protein]decreases reaction|increases activity|increases phosphorylation 12935885
D010656 Phenylephrine Phenylephrine affects the activity of ADRA1A proteinaffects activity 19133277
D010656 Phenylephrine [Phenylephrine affects the activity of ADRA1A protein] which affects the transport of Potassiumaffects activity|affects transport 19133277
D010656 Phenylephrine Phenylephrine binds to and results in increased activity of ADRA1A proteinaffects binding|increases activity 15672411
15550506
D010656 Phenylephrine [Phenylephrine binds to and results in increased activity of ADRA1A protein] which results in increased transport of Calciumaffects binding|increases activity|increases transport 15672411
D010656 Phenylephrine Phenylephrine results in increased activity of ADRA1A proteinincreases activity 15603588
12935885
D010656 Phenylephrine [Phenylephrine results in increased activity of ADRA1A protein] which results in increased phosphorylation of EIF4EBP1 proteinincreases activity|increases phosphorylation 12935885
D010656 Phenylephrine [Phenylephrine results in increased activity of ADRA1A protein] which results in increased phosphorylation of MTOR proteinincreases activity|increases phosphorylation 12935885
D010656 Phenylephrine [Phenylephrine results in increased activity of ADRA1A protein] which results in increased phosphorylation of RPS6KB1 proteinincreases activity|increases phosphorylation 12935885
D010656 Phenylephrine [Phenylephrine results in increased activity of ADRA1A protein] which results in increased transport of Glucoseincreases activity|increases transport 15550506
D010716 Phosphatidylinositols ADRA1A protein results in increased hydrolysis of Phosphatidylinositolsincreases hydrolysis 11195782
C006253 pirinixic acid pirinixic acid results in increased expression of ADRA1A mRNAincreases expression 18301758
C025299 polyphenols polyphenols results in decreased expression of ADRA1A mRNAdecreases expression 16293270
D011188 Potassium [Forskolin co-treated with 1-Methyl-3-isobutylxanthine] affects the reaction [[Phenylephrine binds to and results in increased activity of ADRA1A protein] which affects the transport of Potassium]affects binding|affects cotreatment|affects reaction|affects transport|increases activity 19419905
D011188 Potassium KT 5720 inhibits the reaction [[Phenylephrine results in increased activity of ADRA1A protein] which results in decreased transport of Potassium]decreases reaction|decreases transport|increases activity 15365637
D011188 Potassium [Phenylephrine binds to and results in increased activity of ADRA1A protein] which affects the transport of Potassiumaffects binding|affects transport|increases activity 19419905
D011188 Potassium [Phenylephrine results in increased activity of ADRA1A protein] which affects the transport of Potassiumaffects transport|increases activity 15365637
D011188 Potassium Prazosin inhibits the reaction [[Phenylephrine results in increased activity of ADRA1A protein] which results in decreased transport of Potassium]decreases reaction|decreases transport|increases activity 15365637
D011188 Potassium Ro 32-0432 inhibits the reaction [[Phenylephrine results in increased activity of ADRA1A protein] which results in decreased transport of Potassium]decreases reaction|decreases transport|increases activity 15365637
D011188 Potassium [Phenylephrine affects the activity of ADRA1A protein] which affects the transport of Potassiumaffects activity|affects transport 19133277
D011224 Prazosin 1-(2-(3-methoxyphenyl)ethyl)phenoxy-3-(dimethylamino)-2-propanol inhibits the reaction [Prazosin binds to ADRA1A protein]affects binding|decreases reaction 11937776
D011224 Prazosin Ketanserin inhibits the reaction [Prazosin binds to ADRA1A protein]affects binding|decreases reaction 11937776
D011224 Prazosin Prazosin binds to and results in decreased activity of ADRA1A proteinaffects binding|decreases activity 15627480
D011224 Prazosin Prazosin inhibits the reaction [[Phenylephrine results in increased activity of ADRA1A protein] which results in decreased transport of Potassium]decreases reaction|decreases transport|increases activity 15365637
D011224 Prazosin sarpogrelate inhibits the reaction [Prazosin binds to ADRA1A protein]affects binding|decreases reaction 11937776
D011224 Prazosin Prazosin binds to and results in decreased activity of ADRA1A proteinaffects binding|decreases activity 12560108
D011224 Prazosin Prazosin binds to and results in decreased activity of ADRA1A proteinaffects binding|decreases activity 15951348
15550506
D011224 Prazosin Prazosin inhibits the reaction [[cirazoline results in increased activity of ADRA1A protein] which results in increased transport of Glucose]decreases reaction|increases activity|increases transport 15550506
D011224 Prazosin Prazosin results in increased expression of ADRA1A mRNAincreases expression 11693201
D019269 Phosphatidylinositol 4,5-Diphosphate [Phenylephrine binds to and results in increased activity of ADRA1A protein] which affects the abundance of Phosphatidylinositol 4,5-Diphosphateaffects abundance|affects binding|increases activity 19419905
D020849 Raloxifene Raloxifene results in decreased expression of ADRA1A mRNAdecreases expression 20201831
C085989 Ro 32-0432 Ro 32-0432 inhibits the reaction [[Phenylephrine results in increased activity of ADRA1A protein] which results in decreased transport of Potassium]decreases reaction|decreases transport|increases activity 15365637
C120711 RS 100329 RS 100329 binds to and results in decreased activity of ADRA1A proteinaffects binding|decreases activity 19566752
C064294 sarpogrelate sarpogrelate inhibits the reaction [Prazosin binds to ADRA1A protein]affects binding|decreases reaction 11937776
D013311 Streptozocin Streptozocin results in increased expression of ADRA1A mRNAincreases expression 19133277
D013311 Streptozocin Streptozocin results in increased expression of ADRA1A proteinincreases expression 19133277
D013739 Testosterone Testosterone results in increased expression of ADRA1A proteinincreases expression 18157169
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of ADRA1A mRNAdecreases expression 20106945
D014147 Tramadol Tramadol results in increased expression of ADRA1A proteinincreases expression 15464068
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Diethylhexyl Phthalate 11.376734493
MESH:D000014 Abnormalities, Drug-Induced Ethanol 11.3718926900 17676605
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 11.3714514962 15322242 11752688
MESH:D000138 Acidosis Ammonium Chloride 8.7218287403
MESH:D000138 Acidosis Ethanol 8.7211192467
MESH:D055371 Acute Lung Injury Oxygen 7.6116759491
MESH:D055371 Acute Lung Injury pirinixic acid 7.6118653653
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 2.433712494
MESH:D018248 Adenoma, Liver Cell pirinixic acid 8.1516434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 8.1516835633
MESH:D000382 Agricultural Workers' Diseases Chlorpyrifos 11.5217119214 11874814 16611668
MESH:D000382 Agricultural Workers' Diseases Diazinon 11.5216487989
MESH:D000382 Agricultural Workers' Diseases Paraquat 11.5211874814
MESH:D000419 Albuminuria Raloxifene 4.0917308373 17451421
MESH:D020268 Alcohol-Induced Disorders, Nervous System Ethanol 4.7815451039 15451040
MESH:D000544 Alzheimer Disease Raloxifene 2.4115800139
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.4911748828
MESH:D000853 Anophthalmos Ethanol 4.3015513904
MESH:D000860 Anoxia Oxygen 4.5320872349
MESH:D000987 Antisocial Personality Disorder Testosterone 5.327506515
MESH:D001008 Anxiety Disorders Ethanol 3.5811141031
MESH:D001145 Arrhythmias, Cardiac Phenylephrine 3.6617460149
MESH:D001249 Asthma Mustard Gas 2.5310378619
MESH:D050197 Atherosclerosis Oxygen 3.4816391483
MESH:D001321 Autistic Disorder Norepinephrine 3.448570775
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 4.481440618 11289319
MESH:D001768 Blister Mustard Gas 4.6319167455
MESH:D001778 Blood Coagulation Disorders pirinixic acid 7.2019483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 7.2012125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.2515340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.4115746008
MESH:D001919 Bradycardia Phenylephrine 4.0215306635
MESH:D001930 Brain Injuries Raloxifene 3.9616580743
MESH:D001943 Breast Neoplasms Oxygen 1.9717263869
MESH:D001943 Breast Neoplasms Raloxifene 1.9715758505 15775269 17440819 17952589 17893378 17261762 17049068 17595753 15572757 16837676 16912660 17242785
MESH:D001943 Breast Neoplasms Testosterone 1.9717261762
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9720435547
MESH:D001989 Bronchiolitis Obliterans Mustard Gas 4.6315286001
MESH:D029481 Bronchitis, Chronic Mustard Gas 4.4417687719 10378619
MESH:D002056 Burns Ethanol 4.1416374292
MESH:D002276 Carcinoid Tumor Streptozocin 5.0616051944
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.3816835633
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 2.887296757 3581430
MESH:D006528 Carcinoma, Hepatocellular Ethanol 2.8818788625 15763234 15289165
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.417296757
MESH:D002295 Carcinoma, Transitional Cell Raloxifene 3.6117572228
MESH:D006332 Cardiomegaly Doxazosin 18.1915969258
MESH:D006332 Cardiomegaly Ethanol 18.1919332462
MESH:D006332 Cardiomegaly Norepinephrine 18.1911179087
MESH:D006332 Cardiomegaly Phenylephrine 18.1916170337 15728586 17124262 11754973 11179087 17287366
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 18.1918670907 18850075 16120746
MESH:D002318 Cardiovascular Diseases Raloxifene 3.0715775269
MESH:D002375 Catalepsy Norepinephrine 5.018216760
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 5.337505956
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 5.3312371664
MESH:D002659 Child Development Disorders, Pervasive Testosterone 3.4620678186
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 2.7216835633
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 11.0719486331 9022650
MESH:D002779 Cholestasis Cyclosporine 11.0719486331
MESH:D002779 Cholestasis pirinixic acid 11.0719176532
MESH:D002971 Cleft Lip Ethanol 3.2915513904
MESH:D002972 Cleft Palate Ethanol 5.1315513904
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 5.1315668235 16354765 15340226 12621046 8697196
MESH:D003072 Cognition Disorders Raloxifene 4.1015800139
MESH:D003110 Colonic Neoplasms polyphenols 2.5816293270
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.6117141729 14669216
MESH:D019465 Craniofacial Abnormalities Ethanol 2.4310194807 11198716 15451039 11873399 19302082 15513904 15451040
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.4320055451 15322242 10048152
MESH:D003456 Cryptorchidism Dibutyl Phthalate 4.9516037377
MESH:D003865 Depressive Disorder, Major Raloxifene 3.7217474826
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 2.3214531868 11298694 2524372 8970840 11906362 18759878 8156756 12868966
MESH:D003876 Dermatitis, Atopic Diethylhexyl Phthalate 6.0816882537
MESH:D003876 Dermatitis, Atopic pirinixic acid 6.0818249437
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.012952479 3621924
MESH:D003920 Diabetes Mellitus Streptozocin 4.2816285004
MESH:D003921 Diabetes Mellitus, Experimental marker/mechanism 19133277
MESH:D003921 Diabetes Mellitus, Experimental Streptozocin 4.0517874149 19496084 15831366 15862027 11260395 19960420 18715473 18603373 12446591 7637645 12083368 16684804 19586609 16286809 11055810 1374869 2177838 19298542 12093613 15298345 12644472 8740154 6379147 17442507
MESH:D003922 Diabetes Mellitus, Type 1 Streptozocin 3.4518603373
MESH:D003924 Diabetes Mellitus, Type 2 Streptozocin 4.1219647726 19586609
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.1217107852
MESH:D058065 Diabetic Cardiomyopathies Streptozocin 5.2016025228
MESH:D003928 Diabetic Nephropathies Raloxifene 7.9917308373 15920148 17451421
MESH:D003928 Diabetic Nephropathies Streptozocin 7.9919682444 19960420
MESH:D003930 Diabetic Retinopathy Streptozocin 4.9217662242
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 10.0516192314 8291058 18289764 18648102 7440962 18692083 1440618 9022650 6679447 9653073 6482804 11289319 9328219
MESH:D056486 Drug-Induced Liver Injury Ethanol 10.0511566570
MESH:D056486 Drug-Induced Liver Injury polyphenols 10.0519370779
MESH:D056486 Drug-Induced Liver Injury Prazosin 10.0518071297
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 10.0520420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.3611462148
MESH:D004417 Dyspnea Diazinon 8.9716487989
MESH:D004417 Dyspnea Oxygen 8.9720016425
MESH:D004487 Edema Mustard Gas 12.6111402378 9260866 11428647 11428631
MESH:D004487 Edema pirinixic acid 12.6112083418
MESH:D004487 Edema Raloxifene 12.6115860553
MESH:D004487 Edema Tetrachlorodibenzodioxin 12.6111000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.3615322242 16714409 18230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Raloxifene 3.5015845917
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.579294722 10568697
MESH:D004827 Epilepsy Epinephrine 6.83821787
MESH:D004827 Epilepsy Norepinephrine 6.83821787
MESH:D004890 Erythema Mustard Gas 4.639357497
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 4.093581430
MESH:D004938 Esophageal Neoplasms Ethanol 4.0916704527
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.6111564622
MESH:D005234 Fatty Liver Cyclosporine 14.9419224547
MESH:D005234 Fatty Liver Ethanol 14.9416409862 19236843 18620774
MESH:D005234 Fatty Liver pirinixic acid 14.9420131406 19236843
MESH:D005234 Fatty Liver Raloxifene 14.9417473493
MESH:D005235 Fatty Liver, Alcoholic Ethanol 5.1317920746
MESH:D005310 Fetal Alcohol Syndrome Ethanol 4.7716946407 15451040 15513904 10194807
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 2.9411858732
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 4.486705139
MESH:D005355 Fibrosis Cyclosporine 6.7812639820 12168785
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 6.7820067830
MESH:D005391 Firesetting Behavior Testosterone 5.327506515
MESH:D005739 Gas Poisoning Oxygen 4.6820016425
MESH:D005756 Gastritis Ethanol 4.1615046732
MESH:D005885 Gingival Hyperplasia Cyclosporine 3.698708960
MESH:D005909 Glioblastoma Testosterone 3.7017162496
MESH:D005911 Gliosis Paraquat 4.6211124998
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 3.557505956
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.0510696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.0410048152 11294989
MESH:D006331 Heart Diseases Raloxifene 6.8811110106
MESH:D006331 Heart Diseases Streptozocin 6.8812093613
MESH:D006333 Heart Failure pirinixic acid 2.2020558911
MESH:D018883 Heat Stroke Ketanserin 6.6416205318
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 3.8915720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 2.8611000095
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 7.926705139
MESH:D006505 Hepatitis Diazinon 7.9216487989
MESH:D006529 Hepatomegaly pirinixic acid 6.5618467677 16221962 19772884 19176532
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 6.5615340226 12621046 16120746
MESH:D006628 Hirsutism Testosterone 5.1117019078
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.5115340226 18606429 8697196 16959395 16354765
MESH:D006930 Hyperalgesia Ethanol 7.2218783367
MESH:D006930 Hyperalgesia Prazosin 7.2212727271
MESH:D017588 Hyperandrogenism Testosterone 4.7717019078
MESH:D006943 Hyperglycemia pirinixic acid 2.7320558911
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 3.4215034207
MESH:D006973 Hypertension Cyclosporine 13.9710903974
MESH:D006973 Hypertension Doxazosin 13.9715969258
MESH:D006973 Hypertension Phenylephrine 13.9712717712 8949925
MESH:D006973 Hypertension Raloxifene 13.9717577099 15787275
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 13.9718670907 18850075
MESH:D006984 Hypertrophy Phenylephrine 4.0812791704 18502941
MESH:D007006 Hypogonadism Testosterone 4.2012002444
MESH:D020514 Hypokalemic Periodic Paralysis Potassium 5.3319822448
MESH:D007018 Hypopituitarism Testosterone 5.6617426086
MESH:D007022 Hypotension Epinephrine 8.536740701
MESH:D007022 Hypotension Norepinephrine 8.536740701
MESH:D007077 Ileal Diseases 1-Methyl-3-isobutylxanthine 4.9018306037
MESH:D007174 Impulse Control Disorders Testosterone 5.327506515
MESH:D007248 Infertility, Male Diazinon 6.0212948887 16466525
MESH:D007248 Infertility, Male Paraquat 6.024850670
MESH:D007249 Inflammation Mustard Gas 6.7017524151 11428631 8975870 11428620 9357497 11402378 9260866 16001271 11428647
MESH:D007249 Inflammation polyphenols 6.7016366677
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 6.7012200463 12878042
MESH:D007333 Insulin Resistance pirinixic acid 2.2816306350
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 4.488074119 9022650
MESH:D007569 Jaw Abnormalities Ethanol 8.5415513904
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 8.5416580747
MESH:D007579 Jejunal Diseases 1-Methyl-3-isobutylxanthine 4.9018306037
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 3.9015604871
MESH:D007674 Kidney Diseases Cyclosporine 5.338314463 10903974 18776723
MESH:D007674 Kidney Diseases Streptozocin 5.3312093613
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 5.856582329
MESH:D007680 Kidney Neoplasms Cyclosporine 5.8512371664
MESH:D007683 Kidney Tubular Necrosis, Acute Calcium 4.5116316344
MESH:D007859 Learning Disorders Ethanol 3.7015451040
MESH:D007889 Leiomyoma Raloxifene 4.0116973256
MESH:D007938 Leukemia 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 3.5212970779
MESH:D017880 Limb Deformities, Congenital Ethanol 3.4317676605
MESH:D008103 Liver Cirrhosis Ethanol 3.0715289165
MESH:D008104 Liver Cirrhosis, Alcoholic Ethanol 4.5718295389
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 2.859327722 15034207
MESH:D008106 Liver Cirrhosis, Experimental Ethanol 3.0318166357
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 3.0315474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.0312878042
MESH:D008107 Liver Diseases Chlorpyrifos 4.1515991261
MESH:D008107 Liver Diseases polyphenols 4.1516698588
MESH:D008108 Liver Diseases, Alcoholic Ethanol 4.1417207112 17347304
MESH:D008113 Liver Neoplasms Diethylhexyl Phthalate 6.1711940454
MESH:D008113 Liver Neoplasms pirinixic acid 6.1720007298 15890375 16377806
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 6.1716984957
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 4.603712494 1399818 6587162 598648
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 4.6012151625
MESH:D008171 Lung Diseases Mustard Gas 3.0918161513 18702808
MESH:D055370 Lung Injury Oxygen 4.0018339021
MESH:D008175 Lung Neoplasms Mustard Gas 2.223148597 8781369
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 2.2211884234 19555203
MESH:D008545 Melanoma Glucose 2.9914993021
MESH:D008569 Memory Disorders Ethanol 3.6918411066 15451040
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.2516801185
MESH:D018200 Mixed Tumor, Mullerian Raloxifene 5.0115863610
MESH:D009101 Multiple Myeloma Raloxifene 3.0616497877
MESH:D009135 Muscular Diseases pirinixic acid 2.9916239165
MESH:D009203 Myocardial Infarction pirinixic acid 1.9119151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.6012213967
MESH:D015428 Myocardial Reperfusion Injury Norepinephrine 7.4615642760
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 7.4616411023
MESH:D009232 Myxoma Raloxifene 5.0116343187
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 2.243581430
MESH:D009369 Neoplasms pirinixic acid 1.6917405874
MESH:D009402 Nephrosis, Lipoid Cyclosporine 3.9017954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 2.8419348381 18481113
MESH:D009410 Nerve Degeneration Paraquat 3.3116893418
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 2.7214600291
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 2.566679447
MESH:D020258 Neurotoxicity Syndromes Chlorpyrifos 3.8015081274
MESH:D009503 Neutropenia Mustard Gas 3.4916761898 7688884
MESH:D009765 Obesity pirinixic acid 1.6720558911
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 2.966482804 4026338
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 4.483988306
MESH:D010024 Osteoporosis Calcium 6.3917882678
MESH:D010024 Osteoporosis Raloxifene 6.3917882678 19059307 15775268
MESH:D015663 Osteoporosis, Postmenopausal Raloxifene 3.7417893378 15579764 17823083 15758505
MESH:D010051 Ovarian Neoplasms 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 3.2016211241
MESH:D010146 Pain 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione 6.9618987195
MESH:D010146 Pain Tramadol 6.9618204346
MESH:D010190 Pancreatic Neoplasms Ethanol 2.7612384795
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 2.977296757
MESH:D010300 Parkinson Disease Paraquat 2.6016140633 15824117 16510128 11124998 15451049 12911755 11181820 11445065
MESH:D010302 Parkinson Disease, Secondary Paraquat 3.9216190885
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 3.7112520081
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 3.936228378
MESH:D011014 Pneumonia Paraquat 3.9312504350
MESH:D011041 Poisoning Diazinon 7.4117603234
MESH:D011041 Poisoning Mustard Gas 7.4115727166
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.0618163543
MESH:D011230 Precancerous Conditions Cyclosporine 2.7812371664
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 2.6711222880 11399792 11896295 11118676
MESH:D019048 Prostatic Intraepithelial Neoplasia Testosterone 4.5820887781
MESH:D011471 Prostatic Neoplasms Raloxifene 3.8016536755 16220300 15731164
MESH:D011537 Pruritus Mustard Gas 3.5718058305
MESH:D011565 Psoriasis Cyclosporine 2.0216882103
MESH:D011658 Pulmonary Fibrosis Mustard Gas 5.1017894541 17266442 17720292 10334151 17620002
MESH:D011658 Pulmonary Fibrosis Paraquat 5.1017997886 16324872
MESH:D011693 Purpura Raloxifene 5.0115770314
MESH:D015427 Reperfusion Injury pirinixic acid 2.1119058328
MESH:D012128 Respiratory Distress Syndrome, Adult Oxygen 7.8317627322 18339021
MESH:D012128 Respiratory Distress Syndrome, Adult Paraquat 7.8311700416
MESH:D012135 Respiratory Sounds Chlorpyrifos 8.2316611668 17119214 11874814
MESH:D012135 Respiratory Sounds Paraquat 8.2311874814
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.3318990726
MESH:D012140 Respiratory Tract Diseases Chlorpyrifos 4.3616611668 17119214
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 7.583692021
MESH:D012162 Retinal Degeneration Paraquat 7.5816458197
MESH:D012640 Seizures Ethanol 2.829754883
MESH:D012729 Sex Chromosome Aberrations Chlorpyrifos 5.556418539
MESH:D012735 Sexual Dysfunction, Physiological Testosterone 5.6616631401
MESH:D012852 Sinusitis Phenylephrine 4.187327846
MESH:D012871 Skin Diseases Mustard Gas 2.5616961503 15451306 12880345
MESH:D012878 Skin Neoplasms Glucose 5.0714993021
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.0716192470
MESH:D013274 Stomach Neoplasms Ethanol 2.3018456281
MESH:D013276 Stomach Ulcer Ethanol 3.0811906479 9562338 16755016 17189318 17918041 9211565
MESH:D020521 Stroke Raloxifene 3.4016837676
MESH:D013375 Substance Withdrawal Syndrome Ethanol 3.809754883
MESH:D013398 Sudden Infant Death Oxygen 5.0212563064
MESH:D013610 Tachycardia Norepinephrine 4.933261545
MESH:D013705 Temporomandibular Joint Disorders polyphenols 4.7117997062
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.3612697716
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 2.496582329 1399818 6587162 3712494 7505956
MESH:D013978 Tibial Fractures Raloxifene 4.6719048282
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 4.438074119
MESH:D001749 Urinary Bladder Neoplasms Raloxifene 4.4317572228
MESH:D014570 Urologic Diseases Diazinon 4.7416487989
MESH:D014605 Uveitis Cyclosporine 3.451336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.0512125929
MESH:D054556 Venous Thromboembolism Raloxifene 4.6716837676
MESH:D014846 Vulvar Neoplasms Raloxifene 5.0116343187
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 3.7115886252
MESH:D014985 Xerophthalmia Cyclosporine 3.9017120751
Pathway ID Pathway Name
KEGG:04020 Calcium signaling pathway
KEGG:04080 Neuroactive ligand-receptor interaction
KEGG:04970 Salivary secretion
REACT:14797 Signaling by GPCR
KEGG:04270 Vascular smooth muscle contraction
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA34
    • No data
    Releated disease ID Related disease Name
    PA447216Schizophrenia
    PA445876Tobacco Use Disorder
    PA443309Alcoholism
    PA445131Obesity
    PA128406954Weight gain
    Releated drug ID Related drug Name
    PA449061clozapine
    PA450626nicotine
    PA450649norepinephrine
    PA451093prazosin
    PA452233antipsychotics
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB00211 agonist Midodrine Vasoconstrictor Agents;Sympathomimetics;Adrenergic alpha-Agonists
    DB00246 antagonist Ziprasidone Antipsychotics;Dopamine Antagonists;Serotonin Antagonists;Antipsychotic Agents
    DB00298 antagonist Dapiprazole Ophthalmologicals;Adrenergic alpha-Antagonists;Antimydriatics;Antipsychotic Agents
    DB00321 antagonist Triavil Tab Adrenergic Uptake Inhibitors;Analgesics, Non-Narcotic;Antidepressive Agents, Tricyclic
    DB00334 antagonist Olanzapine Antiemetics;Antipsychotics;Antipsychotic Agents;Serotonin Uptake Inhibitors
    DB00346 antagonist Alfuzosin Antihypertensive Agents;Adrenergic alpha-Antagonists
    DB00363 antagonist Clozapine Antipsychotics;Serotonin Antagonists;Antipsychotic Agents;GABA Antagonists
    DB00368 agonist Norepinephrine Vasoconstrictor Agents;Sympathomimetics;Adrenergic alpha-Agonists
    DB00388 - Vasosulf Oph Soln Vasoconstrictor Agents;Sympathomimetics;Adrenergic alpha-Agonists;Mydriatics;Cardiotonic Agents;Nasal Decongestants
    DB00397 agonist Tussaminic DH Pediatric Syrup Sympathomimetics;Appetite Depressants;Adrenergic alpha-Agonists;Nasal Decongestants
    DB00420 antagonist Promazine Antiemetics;Antipsychotics;Dopamine Antagonists;Neuroleptics;Phenothiazines;Antipsychotic Agents
    DB00449 agonist Probeta - Liq Oph Sympathomimetics;Ophthalmologicals;Adrenergic Agonists
    DB00450 antagonist Innovar-Vet Inj Antiemetics;Adjuvants, Anesthesia;Dopamine Antagonists;Antipsychotic Agents
    DB00457 antagonist Minizide Antihypertensive Agents;Adrenergic alpha-Antagonists;Alpha-adrenergic Blocking Agents
    DB00458 antagonist Imipramine Adrenergic Uptake Inhibitors;Antidepressive Agents, Tricyclic;Norepinephrine-Reuptake Inhibitors
    DB00477 antagonist Chlorpromazine Antiemetics;Antipsychotics;Dopamine Antagonists;Phenothiazines;Antipsychotic Agents
    DB00540 antagonist Nortriptyline Antidepressants;Adrenergic Uptake Inhibitors;Antidepressive Agents, Tricyclic;Norepinephrine-Reuptake Inhibitors
    DB00543 antagonist Amoxapine Adrenergic Uptake Inhibitors;Dopamine Antagonists;Serotonin Uptake Inhibitors;Antidepressive Agents, Second-Generation;Neurotransmitter Uptake Inhibitors
    DB00590 antagonist Doxazosin Antineoplastic Agents;Antihypertensive Agents;Vasodilator Agents;Adrenergic alpha-Antagonists;Alpha-adrenergic Blocking Agents;Antihyperplasia Agents
    DB00598 antagonist Labetalol Antihypertensive Agents;Adrenergic beta-Antagonists;Sympatholytics;Adrenergic alpha-Antagonists
    DB00610 agonist Metaraminol Vasoconstrictor Agents;Adrenergic Agents;Sympathomimetics;Adrenergic alpha-Agonists
    DB00622 antagonist Nicardipine Antihypertensive Agents;Vasodilator Agents;Antiarrhythmic Agents;Calcium Channel Blockers;Dihydropyridines
    DB00656 antagonist Trazodone Anti-anxiety Agents;Antidepressants, Second-Generation;Serotonin Uptake Inhibitors;Antidepressive Agents, Second-Generation
    DB00668 agonist Zorcaine Vasoconstrictor Agents;Sympathomimetics;Adrenergic alpha-Agonists;Mydriatics;Bronchodilator Agents;Adrenergic beta-Agonists;Adrenergic Agonists
    DB00679 antagonist Thioridazine Antipsychotics;Dopamine Antagonists;Phenothiazines;Antipsychotic Agents
    DB00692 antagonist Phentolamine Antihypertensive Agents;Sympatholytics;Adrenergic alpha-Antagonists
    DB00696 partial agonist Wigraine Tab Vasoconstrictor Agents;Sympatholytics;Adrenergic alpha-Agonists;Analgesics, Non-Narcotic
    DB00699 agonist Nicergoline Vasodilator Agents;Adrenergic alpha-Antagonists;Nootropic Agents
    DB00706 antagonist Tamsulosin Antineoplastic Agents;Adrenergic alpha-Antagonists
    DB00723 agonist Methoxamine Vasoconstrictor Agents;Sympathomimetics;Adrenergic alpha-Agonists
    DB00726 antagonist Trimipramine Antidepressants;Adrenergic Uptake Inhibitors;Antidepressive Agents, Tricyclic;Norepinephrine-Reuptake Inhibitors
    DB00734 antagonist Risperidone Antipsychotics;Dopamine Antagonists;Serotonin Antagonists;Antipsychotic Agents
    DB00751 unknown Epinastine Histamine H1 Antagonists;Antihistamines;Ophthalmics
    DB00777 antagonist Propiomazine Sedatives and Hypnotics
    DB00797 antagonist Tolazoline Antihypertensive Agents;Vasodilator Agents;Adrenergic alpha-Antagonists
    DB00831 antagonist Stelabid No 2 Antiemetics;Antipsychotics;Dopamine Antagonists;Phenothiazines;Antipsychotic Agents
    DB00852 agonist Tussin Cough Medicine DM Antitussive Expectorant Decongestant Vasoconstrictor Agents;Adrenergic Agents;Sympathomimetics;Central Nervous System Agents;Bronchodilator Agents;Nasal Decongestants
    DB00865 agonist Benzphetamine Adrenergic Agents;Dopamine Agents;Dopamine Uptake Inhibitors;Adrenergic Uptake Inhibitors;Central Nervous System Stimulants;Sympathomimetics;Central Nervous System Agents
    DB00875 antagonist Flupenthixol Antipsychotics;Dopamine Antagonists;Antipsychotic Agents;Thioxanthenes
    DB00925 antagonist Phenoxybenzamine Antihypertensive Agents;Vasodilator Agents;Adrenergic alpha-Antagonists
    DB00934 antagonist Maprotiline Antidepressants;Adrenergic Uptake Inhibitors;Antidepressive Agents, Second-Generation
    DB00935 agonist Oxymetazoline Sympathomimetics;Adrenergic alpha-Agonists;Nasal Decongestants
    DB00964 other/unknown Apraclonidine EENT Drugs;Adrenergic alpha-Agonists;Antiglaucomic Agents;Ophthalmics
    DB01049 antagonist Ergoloid mesylate Sympatholytics;Vasodilator Agents;Adrenergic alpha-Antagonists;Nootropic Agents
    DB01069 unknown Phenergan VC Expectorant Syrup Antipruritics;Anti-Allergic Agents;Histamine H1 Antagonists;Phenothiazine Derivatives
    DB01136 antagonist Carvedilol Antihypertensive Agents;Adrenergic Agents;Adrenergic beta-Antagonists;Vasodilator Agents;Adrenergic alpha-Antagonists
    DB01142 antagonist Doxepin Antidepressants;Anti-anxiety Agents;Antipruritics;Antidepressive Agents, Tricyclic;Norepinephrine-Reuptake Inhibitors;Histamine Antagonists
    DB01149 antagonist Nefazodone Antidepressants;Analgesics;Antidepressive Agents, Second-Generation;Serotonin Agents
    DB01151 antagonist Desipramine Antidepressants;Adrenergic Uptake Inhibitors;Enzyme Inhibitors;Antidepressive Agents, Tricyclic;Norepinephrine-Reuptake Inhibitors
    DB01162 antagonist Terazosin Antineoplastic Agents;Adrenergic alpha-Antagonists
    DB01175 antagonist Escitalopram Serotonin Uptake Inhibitors;Antidepressive Agents, Second-Generation
    DB01186 agonist Pergolide Central Nervous System Agents;Antiparkinson Agents;Antidyskinetics;Dopamine Agonists;Neuroprotective Agents
    DB01200 agonist Bromocriptine Antiparkinson Agents;Antidyskinetics;Dopamine Agonists;Hormone Antagonists
    DB01224 antagonist Quetiapine Antipsychotics;Antipsychotic Agents
    DB01238 unknown Aripiprazole Antipsychotics;Antipsychotic Agents
    DB01253 agonist Ergonovine Oxytocics
    DB01267 antagonist Paliperidone Antipsychotic Agents
    DB01287 antagonist Dihydroergotoxine
    DB01295 antagonist Bevantolol Antihypertensive Agents;Adrenergic beta-Antagonists;Calcium Channel Blockers
    DB01364 - Ephedrine Vasoconstrictor Agents;Adrenergic Agents;Central Nervous System Stimulants;Sympathomimetics
    DB01365 agonist Mephentermine Vasoconstrictor Agents;Adrenergic Agents;Sympathomimetics;Adrenergic alpha-Agonists
    DB01403 antagonist Methotrimeprazine Dopamine Antagonists;Analgesics, Non-Narcotic;Antipsychotic Agents
    DB01472 agonist 4-Methoxyamphetamine Hallucinogens
    DB01576 - Adderall XR Adrenergic Agents;Dopamine Agents;Dopamine Uptake Inhibitors;Adrenergic Uptake Inhibitors;Central Nervous System Stimulants;Sympathomimetics
    DB01579 agonist Phendimetrazine Anorexigenic Agents
    DB01614 antagonist Acepromazine Dopamine Antagonists;Antipsychotic Agents;Sedatives and Hypnotics
    DB01622 antagonist Thioproperazine Phenothiazines;Antipsychotic Agents
    DB01624 antagonist Zuclopenthixol Dopamine Antagonists;Antipsychotic Agents
    DB06144 - Sertindole Neuroleptics;Antipsychotic Agents
    DB06262 agonist Droxidopa Vasoconstrictor Agents;Sympathomimetics;Adrenergic alpha-Agonists
    DB06694 agonist Xylometazoline Sympathomimetics;Adrenergic alpha-Agonists;Nasal Decongestants
    DB06706 agonist Isometheptene Sympathomimetics
    DB06707 agonist Levonordefrin Vasoconstrictor Agents;Nasal Decongestants
    DB06711 agonist Naphcon-A Adrenergic alpha-Agonists;Sympathomimetic
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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