AutismKB 2.0

Annotation Detail for TMEM56


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Basic Information Top
Gene Symbol:TMEM56 ( FLJ31842,MGC102912 )
Gene Full Name: transmembrane protein 56
Band: 1p21.3
Quick LinksEntrez ID:148534; OMIM: NA; Uniprot ID:TMM56_HUMAN; ENSEMBL ID: ENSG00000152078; HGNC ID: 26477
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of TMEM56 mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of TMEM56 mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen affects the expression of TMEM56 mRNAaffects expression 17562736
C006780 bisphenol A bisphenol A results in decreased expression of TMEM56 mRNAdecreases expression 20739668
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of TMEM56 mRNAaffects expression 17484886
C006253 pirinixic acid pirinixic acid results in increased expression of TMEM56 mRNAincreases expression 18301758
D014635 Valproic Acid Valproic Acid results in increased expression of TMEM56 mRNAincreases expression 19101580
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 3.888875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 4.2119490988
MESH:D055371 Acute Lung Injury pirinixic acid 3.4218653653
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.8816434500
MESH:D000550 Amblyopia Valproic Acid 5.6817688650
MESH:D000799 Angioedema Acetaminophen 4.2910982225
MESH:D001008 Anxiety Disorders Valproic Acid 3.7917497229
MESH:D001321 Autistic Disorder Acetaminophen 1.8618445737
MESH:D001321 Autistic Disorder Valproic Acid 1.8617688650 20603192 17157402 19232924 17507914 19460635 18985861 18177632 15238991 18940202 18316065 18396377 18558336 16609825 18775368
MESH:D001714 Bipolar Disorder Valproic Acid 3.2020046352 17594078
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.4319483382
MESH:D001848 Bone Diseases, Developmental Valproic Acid 3.578888407
MESH:D001862 Bone Resorption bisphenol A 4.1411985600
MESH:D001943 Breast Neoplasms bisphenol A 2.4417123778
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 4.1416011737 16097048 10355542 15721981 16192424 16124888 16050911 18705752 3786805 15700767 16227642 15673190
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 6.8416705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 6.8416705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 6.843084413
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 6.8418788625
MESH:D002278 Carcinoma in Situ bisphenol A 5.3817123778
MESH:D002386 Cataract Acetaminophen 2.7310977129
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 2.956135515
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.7920734317
MESH:D002779 Cholestasis pirinixic acid 3.0319176532
MESH:D019465 Craniofacial Abnormalities Valproic Acid 1.908888407 17688650 16575769
MESH:D003490 Cyanosis 2,4-dinitrotoluene 12.1218551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 12.1218551238
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5318249437
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 12.7721346803 18551238
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 12.7721346803 18551238
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 12.7714550746 10915739 11739529 16485898 12540782 10774834 12705907 19923254 18713872 19370779 11743745 17522070 11529661 16081117 10663392 19739265 12153990 11287661 18071297 16109766 17906064 12594235 15619225 2444490 11421492 12392966 19420014 19416960 16227642 14986274 19164858 16393943 11834606 14725611 16781746 15968718 19085960 17562736 11461765 12958197 16177239
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 12.7716227642 10092053 11566570 6884620 15998439 21278145 3786805 10915739 19336974 15968718 7120509 4309450 6623471 7179309 19085960 9327722 7440962 17522070 3732212 2869522 16177239 15027814
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 12.7719641884 1733752
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.5419426721
MESH:D004421 Dystonia Valproic Acid 4.351851702
MESH:D004487 Edema pirinixic acid 2.7612083418
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 4.513659116 17275665
MESH:D004828 Epilepsies, Partial Valproic Acid 4.3616628512 3922381
MESH:D004827 Epilepsy Valproic Acid 3.0618234410 20417680
MESH:D004832 Epilepsy, Absence Valproic Acid 3.847562514 6426943 6254150
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 4.667750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 4.463659116
MESH:D005234 Fatty Liver Carbon Tetrachloride 14.8116239168 61145 17595544 19224547 16045604 12631006 15959796 12795759
MESH:D005234 Fatty Liver pirinixic acid 14.8120131406 19236843
MESH:D005234 Fatty Liver Valproic Acid 14.8114986274 19224547
MESH:D005315 Fetal Diseases Valproic Acid 5.3316575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 4.4618558336 8888407
MESH:D005355 Fibrosis Carbon Tetrachloride 3.8118705752
MESH:D005756 Gastritis Acetaminophen 4.1216983495
MESH:D006333 Heart Failure pirinixic acid 2.6920558911
MESH:D006505 Hepatitis Carbon Tetrachloride 3.9219900420 19110552
MESH:D006529 Hepatomegaly pirinixic acid 3.3519772884 18467677 19176532 16221962
MESH:D006849 Hydrocephalus Valproic Acid 5.2617688650
MESH:D006930 Hyperalgesia Acetaminophen 2.9216870215
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.9316899240
MESH:D006943 Hyperglycemia pirinixic acid 3.4520558911
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.4515338365
MESH:D007333 Insulin Resistance bisphenol A 7.8816393666
MESH:D007333 Insulin Resistance pirinixic acid 7.8816306350
MESH:D007674 Kidney Diseases Acetaminophen 2.3415629191 12587719
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 8.1516705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 8.1516705839
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 2.1916294345 17596541
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 2.9417174718 17157831 21278145 16943688 17334410 11903743 16221502 11408273 16239168
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 2.3918277467 15818738 17976157 10355542 17481882 18376398 17869086 18210741 14748882 16015684 17823541 18395914 18418968 17761835 17565644 15338365 18481824 12586293 12632512 12741479 16192424 12632514 14716496 17721639 17631135 12546737 15959796 18429990 16116963 15730626 14620537 18412020 18705752 12898905 15057751 12445418 18395095 16248980 17525996 18251166 16136751 18279442 17944888 15996030 18317297 17557913 18006644 15673190 15931870 17714472 16011737 17708605 17900296 16027843 12666154 17805973 12609069 18205269 14512876 18263696 18054572 12389079 17766677 17922224 16033810 14716833 15123356 15370692 18339082 17640975 20821823 16097048 15052691 12445421 11481614 12649538 13678700 16638106 12667390 15876570 17698563 15925388 18187930 12958196 18166357 18420326 18472332 14724832 15362042 18472094 15650968 18156304 15893842
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 2.3915474484
MESH:D008107 Liver Diseases Acetaminophen 4.0916610002 19460945 11587558 16611625 12587719 12969438 19784758 19014921
MESH:D008107 Liver Diseases Carbon Tetrachloride 4.0916246199 17285989 16964402 15830285 15720792
MESH:D017093 Liver Failure Carbon Tetrachloride 4.5215123358
MESH:D017114 Liver Failure, Acute Acetaminophen 10.3117185352 16871587
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 10.3116899240 14706259
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 7.927678174
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 7.9219294768
MESH:D008113 Liver Neoplasms pirinixic acid 7.9220007298 16377806 15890375
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 6.462876786 6135515 2876784
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 6.4615583823 12014681
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 4.7017228818
MESH:D008546 Melanoma, Experimental Acetaminophen 3.9319513568
MESH:D008881 Migraine Disorders Valproic Acid 3.3818765137 18803445
MESH:D009135 Muscular Diseases pirinixic acid 3.8616239165
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 4.318888407
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 3.3017596541
MESH:D009203 Myocardial Infarction pirinixic acid 2.2419151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.1616411023
MESH:D009336 Necrosis 2,4-dinitrotoluene 11.7018551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 11.707678174 18551238
MESH:D009369 Neoplasms pirinixic acid 2.0617405874
MESH:D009421 Nervous System Malformations bisphenol A 4.3016427766 11399458
MESH:D009436 Neural Tube Defects Valproic Acid 3.308888407 16359493
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.1018514411
MESH:D009765 Obesity pirinixic acid 1.8620558911
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 9.7812819281 16049721
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 9.7816049721
MESH:D010049 Ovarian Diseases bisphenol A 5.3811985600
MESH:D010146 Pain Acetaminophen 2.6216870215
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 11.1010548101
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 11.1020603192
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 4.4920887781
MESH:D011471 Prostatic Neoplasms bisphenol A 3.3616740699
MESH:D019310 Pseudolymphoma Valproic Acid 4.9811422049 12752131
MESH:D011629 Puberty, Precocious bisphenol A 5.1810548101
MESH:D015427 Reperfusion Injury pirinixic acid 2.5019058328
MESH:D012208 Rhabdomyosarcoma Valproic Acid 4.4819155313
MESH:D012559 Schizophrenia Valproic Acid 2.0915737665 19110320
MESH:D012640 Seizures 2,4-dinitrotoluene 10.9018551238
MESH:D012640 Seizures 2,6-dinitrotoluene 10.9018551238
MESH:D012640 Seizures Valproic Acid 10.9011044598 16876388 3137016 15475178 1511512 14763951 17978042 11738929
MESH:D016135 Spinal Dysraphism Valproic Acid 3.9919490988
MESH:D013226 Status Epilepticus Valproic Acid 4.9812833885
MESH:D019966 Substance-Related Disorders bisphenol A 4.3816684133 16045194
MESH:D014178 Translocation, Genetic Valproic Acid 5.6817262798
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.923119515
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 5.3216049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 5.3216049721
MESH:D014564 Urogenital Abnormalities Valproic Acid 5.008888407
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 13.3510091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 13.3510091137
MESH:D014581 Urticaria Acetaminophen 3.2810982225
MESH:D014591 Uterine Diseases bisphenol A 5.4514652134
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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