AutismKB 2.0

Annotation Detail for CTBP1


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Basic Information Top
Gene Symbol:CTBP1 ( BARS,MGC104684 )
Gene Full Name: C-terminal binding protein 1
Band: 4p16.3
Quick LinksEntrez ID:1487; OMIM: 602618; Uniprot ID:CTBP1_HUMAN; ENSEMBL ID: ENSG00000159692; HGNC ID: 2494
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04310Wnt signaling pathway
hsa04330Notch signaling pathway
hsa05220Chronic myeloid leukemia
hsa05200Pathways in cancer
No data
Pathway IDPathway Name
200002Regulation of nuclear SMAD2/3 signaling
200013Notch signaling pathway
200106Regulation of Wnt-mediated beta catenin signaling and target gene transcription
200191Regulation of retinoblastoma protein
200196Notch-mediated HES/HEY network
200052Presenilin action in Notch and Wnt signaling
Pathway IDPathway Name
P00057Wnt signaling pathway
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1809HIV infection
2052Infection
2053Colon cancer
No data
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of CTBP1 mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen affects the expression of CTBP1 mRNAaffects expression 17562736
D000499 Allylamine Allylamine affects the expression of CTBP1 mRNAaffects expression 15910882
D000643 Ammonium Chloride Ammonium Chloride affects the expression of CTBP1 mRNAaffects expression 16483693
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of CTBP1 mRNAdecreases expression 19150397
C006780 bisphenol A bisphenol A results in decreased expression of CTBP1 mRNAdecreases expression 18007998
D003994 Bucladesine Bucladesine affects the localization of CTBP1 proteinaffects localization 18184656
D003994 Bucladesine Bucladesine inhibits the reaction [CTBP1 protein binds to KAT2A protein]affects binding|decreases reaction 18184656
D003994 Bucladesine Bucladesine inhibits the reaction [CTBP1 protein binds to NR5A1 protein]affects binding|decreases reaction 18184656
D003994 Bucladesine Bucladesine promotes the reaction [CTBP1 protein binds to CTBP2 protein]affects binding|increases reaction 18184656
D004958 Estradiol [Progesterone co-treated with Estradiol] results in decreased expression of CTBP1 mRNAaffects cotreatment|decreases expression 17404688
D008628 Mercury Mercury results in increased expression of CTBP1 mRNAincreases expression 16823088
D009151 Mustard Gas Mustard Gas affects the expression of CTBP1 mRNAaffects expression 15651846
D011374 Progesterone [Progesterone co-treated with Estradiol] results in decreased expression of CTBP1 mRNAaffects cotreatment|decreases expression 17404688
D019289 Pyruvic Acid Pyruvic Acid affects the localization of CTBP1 proteinaffects localization 18184656
D019289 Pyruvic Acid Pyruvic Acid inhibits the reaction [CTBP1 protein binds to CTBP2 protein]affects binding|decreases reaction 18184656
D019289 Pyruvic Acid Pyruvic Acid inhibits the reaction [CTBP1 protein binds to NR5A1 protein]affects binding|decreases reaction 18184656
D019289 Pyruvic Acid Pyruvic Acid promotes the reaction [CTBP1 protein binds to CYP17A1 promoter]affects binding|increases reaction 18184656
D012643 Selenium Selenium results in increased expression of CTBP1 mRNAincreases expression 19244175
D014810 Vitamin E Vitamin E results in decreased expression of CTBP1 mRNAdecreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 3.6418287403
MESH:D000230 Adenocarcinoma Estradiol 2.1111473722
MESH:D000799 Angioedema Acetaminophen 3.9410982225
MESH:D001249 Asthma Mustard Gas 2.7210378619
MESH:D001321 Autistic Disorder Acetaminophen 2.1418445737
MESH:D001321 Autistic Disorder Mercury 2.1417497416
MESH:D001327 Autoimmune Diseases Mercury 4.9416634805
MESH:D001768 Blister Mustard Gas 5.2419167455
MESH:D001862 Bone Resorption bisphenol A 3.9211985600
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 5.4317868700
MESH:D001930 Brain Injuries Progesterone 4.3315665606 15380490 15845082
MESH:D001943 Breast Neoplasms bisphenol A 1.9517123778
MESH:D001943 Breast Neoplasms Estradiol 1.9514630087 17289903 16675129 19861407 12948864 17018787 18497071 17261762
MESH:D001943 Breast Neoplasms Progesterone 1.9517614352 15562024 16175315
MESH:D001989 Bronchiolitis Obliterans Mustard Gas 5.2415286001
MESH:D029481 Bronchitis, Chronic Mustard Gas 5.0717687719 10378619
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.5516111702
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 4.0016050911
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 4.5516705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 4.553084413
MESH:D006528 Carcinoma, Hepatocellular Estradiol 4.5516924424
MESH:D002278 Carcinoma in Situ bisphenol A 5.0717123778
MESH:D002311 Cardiomyopathy, Dilated Mercury 3.4710334427
MESH:D002386 Cataract Acetaminophen 2.6110977129
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 11.396135515
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 11.3920889678
MESH:D002471 Cell Transformation, Neoplastic Estradiol 11.3918566989
MESH:D003092 Colitis Selenium 3.8517936198
MESH:D015179 Colorectal Neoplasms marker/mechanism 17028196
MESH:D019465 Craniofacial Abnormalities Vitamin E 1.9119769572
MESH:D003490 Cyanosis 2,6-dinitrotoluene 4.0918551238
MESH:D017449 Dermatitis, Allergic Contact Mercury 3.8616823706
MESH:D003928 Diabetic Nephropathies Estradiol 3.4619279558
MESH:D003929 Diabetic Neuropathies Progesterone 4.5617187935
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 6.2918551238 21346803
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 6.2919416960 17906064 11461765 16177239 16781746 16227642 11739529 19085960 12540782 15619225 14725611 11834606 14550746 19420014 18071297 11287661 12705907 16081117 11743745 11421492 10774834 12958197 10663392 2444490 19370779 15968718 17562736 19923254 16485898 17522070 18713872 14986274 12594235 19739265 12392966 10915739 16393943 16109766 11529661 19164858 12153990
MESH:D056486 Drug-Induced Liver Injury Selenium 6.2915131321
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.1919426721
MESH:C538011 Eales disease Vitamin E 4.809068938
MESH:D004487 Edema Mustard Gas 3.3611428647 11402378 9260866 11428631
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 3.8417692515
MESH:D016889 Endometrial Neoplasms Estradiol 3.0119148513 18566989 11473722
MESH:D004715 Endometriosis Progesterone 3.8216134523
MESH:D004890 Erythema Mustard Gas 5.249357497
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.0920426865
MESH:D005756 Gastritis Acetaminophen 3.7716983495
MESH:D006330 Heart Defects, Congenital Vitamin E 3.0116080930
MESH:D006333 Heart Failure Selenium 3.1117162251
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.7216490937 16863852
MESH:D006558 Herpes Genitalis Estradiol 5.1315709030
MESH:D019584 Hot Flashes Estradiol 10.3817088409
MESH:D019584 Hot Flashes Vitamin E 10.3814716179
MESH:D006930 Hyperalgesia Acetaminophen 2.7416870215
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 4.4715869954
MESH:D007249 Inflammation Mustard Gas 5.4116001271 17524151 11428620 9260866 11402378 9357497 11428631 8975870 11428647
MESH:D007249 Inflammation Progesterone 5.4115869954
MESH:D007251 Influenza, Human Selenium 11.2916624496
MESH:D007251 Influenza, Human Vitamin E 11.2916624496
MESH:D007333 Insulin Resistance bisphenol A 7.5516393666
MESH:D007333 Insulin Resistance Estradiol 7.5516393666 16627594
MESH:D007674 Kidney Diseases Acetaminophen 14.7312587719 15629191
MESH:D007674 Kidney Diseases Estradiol 14.7315618244
MESH:D007674 Kidney Diseases Mercury 14.7317934191
MESH:D007674 Kidney Diseases Vitamin E 14.7312488133
MESH:D007676 Kidney Failure, Chronic Selenium 3.9416518626
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 7.5116705839
MESH:D007680 Kidney Neoplasms Estradiol 7.5115610895
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 2.5114716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 2.5116169303
MESH:D008107 Liver Diseases Acetaminophen 1.6419014921 12969438 19460945 19784758 11587558 16611625 16610002 12587719
MESH:D017114 Liver Failure, Acute Acetaminophen 3.2917185352 16871587
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 2.177678174
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 2.572876786 2876784 6135515
MESH:D008171 Lung Diseases Mustard Gas 7.6618702808 18161513
MESH:D008171 Lung Diseases Vitamin E 7.6616863852
MESH:D008175 Lung Neoplasms Mustard Gas 2.663148597 8781369
MESH:D008175 Lung Neoplasms Vitamin E 2.6611062179
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 10.1916891317 17203775 11807958 11408345
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 10.1917203775 11408345
MESH:D008325 Mammary Neoplasms, Experimental Selenium 10.1915318939
MESH:D020149 Manganese Poisoning Estradiol 4.5819453300
MESH:D008546 Melanoma, Experimental Acetaminophen 3.6419513568
MESH:D008654 Mesothelioma Selenium 2.8115107826
MESH:D015428 Myocardial Reperfusion Injury Estradiol 3.3216810080
MESH:D009336 Necrosis 2,6-dinitrotoluene 3.9418551238 7678174
MESH:D009389 Neovascularization, Pathologic Estradiol 3.8117289903
MESH:D009421 Nervous System Malformations bisphenol A 9.9616427766 11399458
MESH:D009421 Nervous System Malformations Estradiol 9.9616427766 11399458
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.9118514411
MESH:D009503 Neutropenia Mustard Gas 4.0316761898 7688884
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 3.4816049721
MESH:D010049 Ovarian Diseases bisphenol A 5.0711985600
MESH:D010051 Ovarian Neoplasms Estradiol 4.9219401270
MESH:D010051 Ovarian Neoplasms Progesterone 4.9216525653 17393432
MESH:D010146 Pain Acetaminophen 2.4316870215
MESH:D010954 Plasmacytoma Selenium 4.9915087411
MESH:D011041 Poisoning Mustard Gas 3.8515727166
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 4.0310548101
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 10.7420887781
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 10.7420887781
MESH:D011471 Prostatic Neoplasms bisphenol A 2.5716740699
MESH:D011471 Prostatic Neoplasms Estradiol 2.5716740699
MESH:D011471 Prostatic Neoplasms Vitamin E 2.5715084515
MESH:D011537 Pruritus Mustard Gas 4.1718058305
MESH:D011629 Puberty, Precocious bisphenol A 4.8710548101
MESH:D011658 Pulmonary Fibrosis Mustard Gas 2.9417266442 17894541 17720292 10334151 17620002
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.8718045962
MESH:D012640 Seizures 2,6-dinitrotoluene 2.5718551238
MESH:D012871 Skin Diseases Mustard Gas 5.0716961503 12880345 15451306
MESH:D012871 Skin Diseases Vitamin E 5.0718709164
MESH:D013119 Spinal Cord Injuries Progesterone 4.3615862959 16503802
MESH:D020521 Stroke Vitamin E 3.5616517955
MESH:D019966 Substance-Related Disorders bisphenol A 4.0716684133 16045194
MESH:D013978 Tibial Fractures Estradiol 4.7819048282
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 2.3116049721
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 4.4010091137
MESH:D014581 Urticaria Acetaminophen 3.0310982225
MESH:D014591 Uterine Diseases bisphenol A 5.1114652134
Pathway ID Pathway Name
KEGG:05220 Chronic myeloid leukemia
KEGG:04330 Notch signaling pathway
KEGG:05200 Pathways in cancer
KEGG:04310 Wnt signaling pathway
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA26995
    • No data
    No data
    Releated drug ID Related drug Name
    PA164743471adenosine triphosphate
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB01907 - Nicotinamide-Adenine-Dinucleotide
    DB01942 - Formic Acid Antibacterial Agents
    DB03398 - Cysteine Sulfenic Acid
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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