Annotation Detail for SHISA4
Basic Information
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| Gene Symbol: | SHISA4 ( C1orf40,FLJ18233,MGC102893,MGC129812,MGC129813,TMEM58 ) |
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| Gene Full Name: | shisa homolog 4 (Xenopus laevis) |
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| Band: | 1q32.1 |
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| Quick Links | Entrez ID:149345; OMIM: NA; Uniprot ID:SHSA4_HUMAN; ENSEMBL ID: ENSG00000198892; HGNC ID: 27139 |
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| Relate to Another Database: |
SFARIGene;
denovo-db |
| Chemical ID |
Chemical Name |
Interaction |
Interaction Action |
Publication |
|---|
| C472791 |
3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid |
3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in increased expression of SHISA4 mRNA | increases expression | 16788091
|
| D004958 |
Estradiol |
Estradiol results in increased expression of SHISA4 mRNA | increases expression | 20068009
|
| C006253 |
pirinixic acid |
[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of SHISA4 mRNA | affects binding|decreases expression|increases activity | 19710929
|
| Disease ID |
Disease Name |
Direct Evidence |
Inference Chemical Name |
Inference Score |
Publication |
|---|
| MESH:D055371 |
Acute Lung Injury |
|
pirinixic acid |
3.64 | 18653653 |
| MESH:D000230 |
Adenocarcinoma |
|
Estradiol |
2.18 | 11473722 |
| MESH:D018248 |
Adenoma, Liver Cell |
|
pirinixic acid |
4.22 | 16434500 |
| MESH:D001778 |
Blood Coagulation Disorders |
|
pirinixic acid |
3.63 | 19483382 |
| MESH:D001943 |
Breast Neoplasms |
|
Estradiol |
2.10 | 17289903 18497071 12948864 14630087 17018787 19861407 16675129 17261762 |
| MESH:D002181 |
Candidiasis, Vulvovaginal |
|
Estradiol |
5.21 | 16111702 |
| MESH:D006528 |
Carcinoma, Hepatocellular |
|
Estradiol |
1.79 | 16924424 |
| MESH:D002471 |
Cell Transformation, Neoplastic |
|
Estradiol |
3.06 | 18566989 |
| MESH:D002779 |
Cholestasis |
|
pirinixic acid |
3.15 | 19176532 |
| MESH:D003876 |
Dermatitis, Atopic |
|
pirinixic acid |
2.59 | 18249437 |
| MESH:D003928 |
Diabetic Nephropathies |
|
Estradiol |
3.83 | 19279558 |
| MESH:D004487 |
Edema |
|
pirinixic acid |
2.96 | 12083418 |
| MESH:D016889 |
Endometrial Neoplasms |
|
Estradiol |
3.25 | 19148513 11473722 18566989 |
| MESH:D005234 |
Fatty Liver |
|
pirinixic acid |
3.25 | 19236843 20131406 |
| MESH:D006333 |
Heart Failure |
|
pirinixic acid |
2.78 | 20558911 |
| MESH:D006529 |
Hepatomegaly |
|
pirinixic acid |
3.64 | 18467677 19176532 19772884 16221962 |
| MESH:D006558 |
Herpes Genitalis |
|
Estradiol |
5.90 | 15709030 |
| MESH:D019584 |
Hot Flashes |
|
Estradiol |
4.62 | 17088409 |
| MESH:D006943 |
Hyperglycemia |
|
pirinixic acid |
3.63 | 20558911 |
| MESH:D007333 |
Insulin Resistance |
|
Estradiol |
8.10 | 16627594 16393666 |
| MESH:D007333 |
Insulin Resistance |
|
pirinixic acid |
8.10 | 16306350 |
| MESH:D007674 |
Kidney Diseases |
|
Estradiol |
2.80 | 15618244 |
| MESH:D007680 |
Kidney Neoplasms |
|
Estradiol |
3.36 | 15610895 |
| MESH:D008106 |
Liver Cirrhosis, Experimental |
|
Estradiol |
2.40 | 14716833 14659978 |
| MESH:D008106 |
Liver Cirrhosis, Experimental |
|
pirinixic acid |
2.40 | 15474484 |
| MESH:D008113 |
Liver Neoplasms |
|
pirinixic acid |
1.94 | 16377806 15890375 20007298 |
| MESH:D008325 |
Mammary Neoplasms, Experimental |
|
Estradiol |
2.82 | 16891317 11807958 17203775 11408345 |
| MESH:D020149 |
Manganese Poisoning |
|
Estradiol |
5.35 | 19453300 |
| MESH:D009135 |
Muscular Diseases |
|
pirinixic acid |
4.16 | 16239165 |
| MESH:D009203 |
Myocardial Infarction |
|
pirinixic acid |
2.29 | 19151258 |
| MESH:D015428 |
Myocardial Reperfusion Injury |
|
Estradiol |
9.41 | 16810080 |
| MESH:D015428 |
Myocardial Reperfusion Injury |
|
pirinixic acid |
9.41 | 16411023 |
| MESH:D009369 |
Neoplasms |
|
pirinixic acid |
2.12 | 17405874 |
| MESH:D009389 |
Neovascularization, Pathologic |
|
Estradiol |
4.47 | 17289903 |
| MESH:D009421 |
Nervous System Malformations |
|
Estradiol |
4.23 | 16427766 11399458 |
| MESH:D009765 |
Obesity |
|
pirinixic acid |
1.89 | 20558911 |
| MESH:D010051 |
Ovarian Neoplasms |
|
Estradiol |
2.32 | 19401270 |
| MESH:D019048 |
Prostatic Intraepithelial Neoplasia |
|
Estradiol |
4.37 | 20887781 |
| MESH:D011471 |
Prostatic Neoplasms |
|
Estradiol |
3.02 | 16740699 |
| MESH:D015427 |
Reperfusion Injury |
|
pirinixic acid |
2.56 | 19058328 |
| MESH:D013978 |
Tibial Fractures |
|
Estradiol |
5.55 | 19048282 |
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