AutismKB 2.0

Annotation Detail for CTNNA1


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Basic Information Top
Gene Symbol:CTNNA1 ( CAP102,FLJ36832,FLJ52416 )
Gene Full Name: catenin (cadherin-associated protein), alpha 1, 102kDa
Band: 5q31.2
Quick LinksEntrez ID:1495; OMIM: 116805; Uniprot ID:CTNA1_HUMAN; ENSEMBL ID: ENSG00000044115; HGNC ID: 2509
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04670Leukocyte transendothelial migration
hsa05412Arrhythmogenic right ventricular cardiomyopathy (ARVC)
hsa04530Tight junction
hsa05100Bacterial invasion of epithelial cells
hsa04520Adherens junction
hsa05213Endometrial cancer
hsa05200Pathways in cancer
Pathway IDPathway Name
Myogenesis
Cell junction organization
Pathway IDPathway Name
200032Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
200155Stabilization and expansion of the E-cadherin adherens junction
200125E-cadherin signaling in keratinocytes
200180N-cadherin signaling events
200046Arf6 trafficking events
200105E-cadherin signaling in the nascent adherens junction
200190RAC1 signaling pathway
200053Nectin adhesion pathway
200057CDC42 signaling events
Pathway IDPathway Name
P00004Alzheimer disease-presenilin pathway
P00012Cadherin signaling pathway
P00057Wnt signaling pathway
Pathway IDPathway Name
500120Adherens junctions interactions
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1728Gastrointestinal tumor
1809HIV infection
1859Ovarian cancer
2074Asthma
No data
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of CTNNA1 mRNAaffects expression 17562736
D013196 Dihydrotestosterone Dihydrotestosterone results in decreased expression of CTNNA1 mRNAdecreases expression 17023530
D000638 Amiodarone Amiodarone affects the expression of CTNNA1 mRNAaffects expression 19483382
D000643 Ammonium Chloride Ammonium Chloride results in increased expression of CTNNA1 proteinincreases expression 16483693
D001149 Arsenates [Atrazine co-treated with Arsenates] results in increased expression of CTNNA1 mRNAaffects cotreatment|increases expression 18585445
C006632 arsenic trioxide arsenic trioxide results in decreased expression of CTNNA1 mRNAdecreases expression 15761015
D001280 Atrazine [Atrazine co-treated with Arsenates] results in increased expression of CTNNA1 mRNAaffects cotreatment|increases expression 18585445
D001553 Benzbromarone Benzbromarone affects the expression of CTNNA1 mRNAaffects expression 19483382
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of CTNNA1 mRNAdecreases expression 20018196
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in decreased expression of CTNNA1 mRNAdecreases expression 12419474
D002994 Clofibrate Clofibrate affects the expression of CTNNA1 mRNAaffects expression 19483382
C014347 decitabine [decitabine co-treated with vorinostat] affects the expression of CTNNA1 mRNAaffects cotreatment|affects expression 17330099
D004051 Diethylhexyl Phthalate Diethylhexyl Phthalate results in increased expression of CTNNA1 proteinincreases expression 16678996
D002117 Calcitriol Calcitriol results in decreased expression of CTNNA1 mRNAdecreases expression 12875902
D005001 Ethionine Ethionine affects the expression of CTNNA1 mRNAaffects expression 19483382
C056933 fumonisin B1 fumonisin B1 results in increased expression of CTNNA1 mRNAincreases expression 16221962
D006861 Hydrogen Peroxide Hydrogen Peroxide results in decreased expression of CTNNA1 mRNAdecreases expression 12419474
D008345 Manganese Manganese results in decreased expression of CTNNA1 mRNAdecreases expression 17175027
C025340 manganese chloride manganese chloride results in decreased expression of CTNNA1 mRNAdecreases expression 17175027
C030667 methylazoxymethanol methylazoxymethanol results in increased expression of CTNNA1 mRNAincreases expression 17107856
D016685 Mitomycin CTNNA1 protein affects the susceptibility to Mitomycinaffects response to substance 16217747
D009853 Omeprazole Omeprazole affects the expression of CTNNA1 mRNAaffects expression 19483382
D010634 Phenobarbital Phenobarbital results in increased expression of CTNNA1 mRNAincreases expression 12082028
C006253 pirinixic acid pirinixic acid results in increased expression of CTNNA1 mRNAincreases expression 16221962
C006253 pirinixic acid pirinixic acid affects the expression of CTNNA1 mRNAaffects expression 19483382
D011441 Propylthiouracil Propylthiouracil affects the expression of CTNNA1 mRNAaffects expression 19483382
D011794 Quercetin Quercetin results in increased expression of CTNNA1 mRNAincreases expression 15309432
D012643 Selenium Selenium results in increased expression of CTNNA1 mRNAincreases expression 19244175
C016104 sodium bichromate sodium bichromate results in decreased expression of CTNNA1 mRNAdecreases expression 12760830
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of CTNNA1 mRNAincreases expression 20106945
D013853 Thioacetamide Thioacetamide affects the expression of CTNNA1 mRNAaffects expression 19483382
D014212 Tretinoin Tretinoin results in decreased expression of CTNNA1 mRNAdecreases expression 12875902
D014212 Tretinoin Tretinoin results in increased expression of CTNNA1 mRNAincreases expression 16236135
D014415 Tunicamycin Tunicamycin results in decreased expression of CTNNA1 mRNAdecreases expression 17127020
C111237 vorinostat [decitabine co-treated with vorinostat] affects the expression of CTNNA1 mRNAaffects cotreatment|affects expression 17330099
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Diethylhexyl Phthalate 12.466734493
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 12.466195326
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 12.4615322242 14514962 11752688
MESH:D000138 Acidosis Ammonium Chloride 3.2318287403
MESH:D055371 Acute Lung Injury pirinixic acid 2.8218653653
MESH:D000230 Adenocarcinoma arsenic trioxide 2.2111798837 19825857
MESH:D018248 Adenoma, Liver Cell Phenobarbital 15.4017620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 15.4016434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 15.4016835633
MESH:D000382 Agricultural Workers' Diseases Atrazine 3.9011874814
MESH:D000505 Alopecia Tretinoin 3.3615955085
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.6711748828
MESH:D000743 Anemia, Hemolytic Quercetin 3.9517084956
MESH:D000756 Anemia, Sideroblastic Manganese 10.0616910769
MESH:D000756 Anemia, Sideroblastic manganese chloride 10.0616910769
MESH:D000799 Angioedema Acetaminophen 3.5110982225
MESH:D001145 Arrhythmias, Cardiac Amiodarone 3.5218218290 18057881 20041841
MESH:D001169 Arthritis, Experimental Tretinoin 2.8816412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.1916292516
MESH:D001249 Asthma Tretinoin 2.2416456186
MESH:D001260 Ataxia Telangiectasia Quercetin 4.6515336622
MESH:D001281 Atrial Fibrillation Amiodarone 3.6618651412 19698954
MESH:D001321 Autistic Disorder Acetaminophen 1.4518445737
MESH:D001327 Autoimmune Diseases Quercetin 4.0919761891
MESH:D001471 Barrett Esophagus Tretinoin 4.0916935849
MESH:D001778 Blood Coagulation Disorders Amiodarone 67.3919483382
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 67.3916206674
MESH:D001778 Blood Coagulation Disorders Benzbromarone 67.3919483382
MESH:D001778 Blood Coagulation Disorders Clofibrate 67.3919483382
MESH:D001778 Blood Coagulation Disorders Ethionine 67.3919483382
MESH:D001778 Blood Coagulation Disorders Omeprazole 67.3919483382
MESH:D001778 Blood Coagulation Disorders pirinixic acid 67.3919483382
MESH:D001778 Blood Coagulation Disorders Propylthiouracil 67.3919483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 67.3912125929
MESH:D001778 Blood Coagulation Disorders Thioacetamide 67.3919483382
MESH:D001778 Blood Coagulation Disorders Tretinoin 67.3916197459 16206674
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.4615340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.5615746008
MESH:D001943 Breast Neoplasms Calcitriol 2.8011237771
MESH:D001943 Breast Neoplasms decitabine 2.8019208741 18320071
MESH:D001943 Breast Neoplasms Quercetin 2.8018628248
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.8020435547
MESH:D001943 Breast Neoplasms Tretinoin 2.8016166294 16443354 16873071
MESH:D001943 Breast Neoplasms vorinostat 2.8016144943
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.2616813970
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.0311589617
MESH:D002105 Cadmium Poisoning Quercetin 5.2116962696
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.5516835633
MESH:D018236 Carcinoma, Embryonal Tretinoin 4.8316168501
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 13.183084413
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 13.1815553829 14691202 16217749 15073043 11135700
MESH:D006528 Carcinoma, Hepatocellular Benzbromarone 13.181701930
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 13.1820935162 1701930 6705139 20007298 17173139
MESH:D006528 Carcinoma, Hepatocellular Quercetin 13.1812508355 19519916
MESH:D006528 Carcinoma, Hepatocellular Thioacetamide 13.1817997003
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 13.181917145
MESH:D021441 Carcinoma, Pancreatic Ductal Quercetin 4.6417234771
MESH:D002291 Carcinoma, Papillary arsenic trioxide 4.5419014326
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 3.8412490120
MESH:D002294 Carcinoma, Squamous Cell Calcitriol 7.0211237771
MESH:D002294 Carcinoma, Squamous Cell decitabine 7.0219215824
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 7.0216051514 16096774
MESH:D006332 Cardiomegaly Quercetin 6.2019794523
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 6.2018670907 18850075 16120746
MESH:D002311 Cardiomyopathy, Dilated Amiodarone 2.7819225199 15710769
MESH:D002318 Cardiovascular Diseases Hydrogen Peroxide 3.2916936243
MESH:D002341 Carotid Artery Thrombosis Amiodarone 4.7618974383
MESH:D002386 Cataract Acetaminophen 6.5910977129
MESH:D002386 Cataract Tretinoin 6.5917460283
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 6.1820889678
MESH:D002471 Cell Transformation, Neoplastic Clofibrate 6.181399818
MESH:D002493 Central Nervous System Diseases Phenobarbital 3.934080065
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.2616129372
MESH:D002637 Chest Pain Omeprazole 4.7815447763
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 8.6416835633
MESH:D018281 Cholangiocarcinoma Thioacetamide 8.6418291259
MESH:D002779 Cholestasis pirinixic acid 2.5919176532
MESH:D002822 Choriocarcinoma Tretinoin 4.8316461808
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 5.3015340226 8697196 12621046 15668235 16354765
MESH:D002972 Cleft Palate Tretinoin 5.309407595
MESH:D003092 Colitis Selenium 8.4417936198
MESH:D003092 Colitis Tretinoin 8.4417035595
MESH:D003110 Colonic Neoplasms decitabine 3.7217616700
MESH:D003110 Colonic Neoplasms Quercetin 3.7217148506 15741050 19440933 17191121 11134977 19056647 16640504
MESH:D015179 Colorectal Neoplasms arsenic trioxide 3.3120501625
MESH:D015179 Colorectal Neoplasms decitabine 3.3118981723
MESH:D015179 Colorectal Neoplasms Quercetin 3.3118852136 18095365
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.7914669216 17141729
MESH:D023903 Coronary Restenosis arsenic trioxide 3.8812609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 3.5410525206
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 3.5410048152 20055451 15322242
MESH:D019465 Craniofacial Abnormalities Tretinoin 3.5417551590 9664655 16925845 9125849 10589399 9224671 9142499 8800419 9211117 14991402
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 3.8015213294
MESH:D003876 Dermatitis, Atopic Diethylhexyl Phthalate 6.4616882537
MESH:D003876 Dermatitis, Atopic pirinixic acid 6.4618249437
MESH:D003921 Diabetes Mellitus, Experimental Quercetin 3.4719496084
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.5917107852
MESH:D003967 Diarrhea vorinostat 4.1920479100
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 13.9019164858 11834606 18713872 19739265 11743745 11529661 11739529 10915739 19420014 16227642 19923254 12705907 19370779 11461765 2444490 11287661 10663392 12153990 16485898 19416960 16393943 17906064 12594235 18071297 17562736 17522070 15619225 11421492 19085960 16781746 15968718 12958197 16109766 14725611 16081117 14986274 10774834 12540782 12392966 16177239 14550746
MESH:D056486 Drug-Induced Liver Injury Amiodarone 13.9015265979 18218290
MESH:D056486 Drug-Induced Liver Injury fumonisin B1 13.9016221962
MESH:D056486 Drug-Induced Liver Injury Selenium 13.9015131321
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 13.9020420201
MESH:D056486 Drug-Induced Liver Injury Thioacetamide 13.9012963478
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.7719426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.5211462148
MESH:D004381 Duodenal Ulcer Omeprazole 4.0221218061 16613094 15991576 17151854
MESH:D050171 Dyslipidemias Clofibrate 3.8316707586
MESH:D004421 Dystonia Phenobarbital 3.701851702
MESH:D004487 Edema pirinixic acid 5.5912083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 5.5912711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 10.8416714409 15322242 18230668
MESH:D004489 Edema, Cardiac Tretinoin 10.8418230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Calcitriol 3.6315138306
MESH:D004701 Endocrine Gland Neoplasms decitabine 4.7819294695
MESH:D016889 Endometrial Neoplasms Tretinoin 2.9016569247
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.749294722 10568697
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 3.793659116
MESH:D004828 Epilepsies, Partial Phenobarbital 3.543922381 11558140
MESH:D004827 Epilepsy Phenobarbital 2.7220417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.276401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 3.937750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 3.693659116
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 4.1620426865
MESH:D004938 Esophageal Neoplasms arsenic trioxide 4.1612903497
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 8.0411564622
MESH:D005124 Eye Abnormalities Tretinoin 8.0416938888 9664655
MESH:D005221 Fatigue vorinostat 5.2720479100
MESH:D005218 Fat Necrosis Thioacetamide 5.3916456712
MESH:D005234 Fatty Liver Amiodarone 16.4414986274
MESH:D005234 Fatty Liver arsenic trioxide 16.4415073043
MESH:D005234 Fatty Liver Clofibrate 16.4419224547
MESH:D005234 Fatty Liver pirinixic acid 16.4420131406 19236843
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.1411858732
MESH:D005355 Fibrosis Quercetin 12.9819474275
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 12.9820067830
MESH:D005355 Fibrosis Tretinoin 12.9817994277
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 3.9516904648
MESH:D005756 Gastritis Acetaminophen 3.3416983495
MESH:D005909 Glioblastoma Manganese 10.8017043766
MESH:D005909 Glioblastoma Quercetin 10.8019804834
MESH:D005909 Glioblastoma Tretinoin 10.8017312396
MESH:D005910 Glioma Quercetin 2.9217643826
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.2610696789
MESH:D006258 Head and Neck Neoplasms decitabine 7.1019215824
MESH:D006258 Head and Neck Neoplasms Tretinoin 7.1016096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 4.8316084493
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 5.9610048152 11294989
MESH:D006330 Heart Defects, Congenital Tretinoin 5.9614991402 9664655
MESH:D006333 Heart Failure pirinixic acid 6.2820558911
MESH:D006333 Heart Failure Selenium 6.2817162251
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.0511000095
MESH:D006501 Hepatic Encephalopathy Thioacetamide 4.2815929193 18665440 17276928
MESH:D006505 Hepatitis Thioacetamide 3.9116456712
MESH:D006529 Hepatomegaly Amiodarone 23.7515265979
MESH:D006529 Hepatomegaly fumonisin B1 23.7516221962
MESH:D006529 Hepatomegaly Phenobarbital 23.7516109766
MESH:D006529 Hepatomegaly pirinixic acid 23.7519772884 16221962 18467677 19176532
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 23.7516120746 12621046 15340226
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.7116354765 15340226 16959395 8697196 18606429
MESH:D006930 Hyperalgesia Acetaminophen 6.7816870215
MESH:D006930 Hyperalgesia Tretinoin 6.7816870215
MESH:D006937 Hypercholesterolemia Amiodarone 3.589751232 8137927
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.2516778211
MESH:D006943 Hyperglycemia pirinixic acid 8.3120558911
MESH:D006943 Hyperglycemia Quercetin 8.3118262572 11834736
MESH:D006973 Hypertension Quercetin 4.8018356687
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 4.8018850075 18670907
MESH:D007037 Hypothyroidism Amiodarone 10.5517991464 18020914
MESH:D007037 Hypothyroidism Propylthiouracil 10.5518031379 8137927
MESH:D007248 Infertility, Male Atrazine 6.4512948887
MESH:D007248 Infertility, Male decitabine 6.4517581917
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 1.7012878042 12200463
MESH:D007251 Influenza, Human Quercetin 9.9616624496
MESH:D007251 Influenza, Human Selenium 9.9616624496
MESH:D007333 Insulin Resistance pirinixic acid 2.4216306350
MESH:D007410 Intestinal Diseases Tretinoin 3.4517994277
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 8.9716580747
MESH:D007569 Jaw Abnormalities Tretinoin 8.9717551590 15992940
MESH:D007627 Keloid Quercetin 4.6417086741
MESH:D007674 Kidney Diseases Acetaminophen 5.4515629191 12587719
MESH:D007674 Kidney Diseases Quercetin 5.4516962696
MESH:D007676 Kidney Failure, Chronic Hydrogen Peroxide 9.0616518626
MESH:D007676 Kidney Failure, Chronic Selenium 9.0616518626
MESH:D016773 Leishmaniasis, Cutaneous Omeprazole 3.8419248655
MESH:D007938 Leukemia arsenic trioxide 13.6215070760
MESH:D007938 Leukemia decitabine 13.6219235587 18980019
MESH:D007938 Leukemia Quercetin 13.6217468513
MESH:D007938 Leukemia Tretinoin 13.6217143497
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 3.5117077332 12560223
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 3.9816972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.1914633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 14.3219077051
MESH:D007951 Leukemia, Myeloid decitabine 14.3218454857 17236224 19117987
MESH:D007951 Leukemia, Myeloid Tretinoin 14.3219285840 16932348 16482212
MESH:D015470 Leukemia, Myeloid, Acute marker/mechanism 17330099
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 5.7620471514 17050201 16467208 16968895 19850784
MESH:D015470 Leukemia, Myeloid, Acute decitabine 5.7617679729 18206229 19387464 18704418 19010910 18460780
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 5.7616294345 17596541 19850784
MESH:D015477 Leukemia, Myelomonocytic, Chronic decitabine 5.1318055864
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 6.9315213294 15336539 16966277 16331271 19642359 12679006 16823087 15748426 19035177 11161223 17107899 12018890 17649720 17217047 19225113 15622746 19075265 17869043 11468182 16330433 16112521 12712474 16891316 17712046 9834237
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 6.9317712046 17107899 17361223 16140955 17294898 17339181 19035177 19225113 19642359 17217047 17649720 15748426 9834237 16935935 17506722 17301526 16823087 19029980 19075265 17368321 16788101 16331271 16891316 16766008 12679006
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.0416882451
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.089224671
MESH:D008064 Lipidoses Amiodarone 3.2815342952 17567588
MESH:D008103 Liver Cirrhosis Phenobarbital 2.7221047994
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 6.2615474484
MESH:D008106 Liver Cirrhosis, Experimental Quercetin 6.2612741479
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 6.2612878042
MESH:D008106 Liver Cirrhosis, Experimental Thioacetamide 6.2612891558 15075984 15362042 14739098 18263696 15334695 16511523 16126171 18606216 16098781 17127702 12679928 18395095 18416461 16097051 15078482 17050028 15288473 12531686 11481614 12085344 18031379 15465738 11682029 10677585 15474484 16489207 15316131 18380797 15158331 18615449 15716488 17355460 16343077 17292413 15288472 12557150 15095483 12175628 18032466 17629604 18458672 18295389 16248980 11172339
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 6.2618397230 16248980
MESH:D008107 Liver Diseases Acetaminophen 6.0316610002 19784758 16611625 12969438 12587719 19460945 11587558 19014921
MESH:D008107 Liver Diseases Phenobarbital 6.0319363144
MESH:D008107 Liver Diseases Thioacetamide 6.0315158337 18374380 16337175
MESH:D017114 Liver Failure, Acute Acetaminophen 8.7017185352 16871587
MESH:D017114 Liver Failure, Acute Thioacetamide 8.7015633222 15313186 12479984 17276928
MESH:D008113 Liver Neoplasms arsenic trioxide 19.9214682389
MESH:D008113 Liver Neoplasms Diethylhexyl Phthalate 19.9211940454
MESH:D008113 Liver Neoplasms Mitomycin 19.9215113037
MESH:D008113 Liver Neoplasms Phenobarbital 19.9219812893 8742319 19073162 15975961 21047994 19482888
MESH:D008113 Liver Neoplasms pirinixic acid 19.9220007298 15890375 16377806
MESH:D008113 Liver Neoplasms Quercetin 19.9218980244
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 19.9216984957
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 12.4620377131
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 12.466150874 18308698 2563599 1399818 17172636
MESH:D008114 Liver Neoplasms, Experimental Quercetin 12.4619519916
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 12.4612151625
MESH:D008133 Long QT Syndrome Amiodarone 7.3817391786 15350150 11989578
MESH:D008133 Long QT Syndrome arsenic trioxide 7.3815213294
MESH:D008171 Lung Diseases Amiodarone 3.1612587719
MESH:D017563 Lung Diseases, Interstitial Amiodarone 4.1518516814
MESH:D008175 Lung Neoplasms arsenic trioxide 3.2219825857 11798837
MESH:D008175 Lung Neoplasms Quercetin 3.2216280456
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.2211884234 19555203
MESH:D008223 Lymphoma decitabine 3.1919470736
MESH:D016410 Lymphoma, T-Cell, Cutaneous vorinostat 5.3720479100
MESH:D008325 Mammary Neoplasms, Experimental Selenium 2.5615318939
MESH:D020149 Manganese Poisoning Manganese 5.1916551646 19453300 16568477
MESH:D008527 Medulloblastoma Tretinoin 2.6517453147
MESH:D008545 Melanoma decitabine 3.2216505122 17785578
MESH:D008545 Melanoma Tretinoin 3.2216752155
MESH:D008546 Melanoma, Experimental Acetaminophen 3.2519513568
MESH:D008591 Meningomyelocele Tretinoin 4.1116940565
MESH:D008654 Mesothelioma Atrazine 6.011916698
MESH:D008654 Mesothelioma Selenium 6.0115107826
MESH:D009069 Movement Disorders Manganese 4.7116551646
MESH:D009101 Multiple Myeloma arsenic trioxide 6.6111468182 19417148 15949261 14977855 19549372
MESH:D009101 Multiple Myeloma decitabine 6.6118172295
MESH:D009135 Muscular Diseases pirinixic acid 3.1916239165
MESH:D009181 Mycoses Amiodarone 4.5712754197 17974566
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.3418349030
MESH:D009190 Myelodysplastic Syndromes marker/mechanism 17330099
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 11.2516882451 16105982
MESH:D009190 Myelodysplastic Syndromes decitabine 11.2519010910 19157545 18608210 16882708
MESH:D009190 Myelodysplastic Syndromes Tretinoin 11.2517596541
MESH:D009203 Myocardial Infarction pirinixic acid 5.2619151258
MESH:D009203 Myocardial Infarction Quercetin 5.2619595682
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.7612213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 7.6216411023
MESH:D015428 Myocardial Reperfusion Injury Quercetin 7.6219207477
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.1517484760
MESH:D009325 Nausea vorinostat 5.1920479100
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 3.6516624393
MESH:D009369 Neoplasms decitabine 10.5219470736 19116145 17925555
MESH:D009369 Neoplasms pirinixic acid 10.5217405874
MESH:D009369 Neoplasms Quercetin 10.5215185748
MESH:D009369 Neoplasms Tretinoin 10.5216946489 16594593
MESH:D009410 Nerve Degeneration Manganese 4.0316551646
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 8.4814600291
MESH:D009421 Nervous System Malformations Tretinoin 8.489125849
MESH:D009436 Neural Tube Defects arsenic trioxide 6.6010525206
MESH:D009436 Neural Tube Defects Tretinoin 6.609142499
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.6118514411
MESH:D020078 Neurogenic Inflammation Quercetin 4.0617929310
MESH:D052556 Niemann-Pick Disease, Type C Clofibrate 4.629802331
MESH:D009765 Obesity pirinixic acid 1.7320558911
MESH:D010018 Osteomalacia Phenobarbital 4.0417016548
MESH:D015663 Osteoporosis, Postmenopausal Quercetin 3.9219495926
MESH:D010051 Ovarian Neoplasms arsenic trioxide 10.4219769630 16624393 12452020
MESH:D010051 Ovarian Neoplasms decitabine 10.4219331143 19259094
MESH:D010051 Ovarian Neoplasms Quercetin 10.4219005980
MESH:D010051 Ovarian Neoplasms Tretinoin 10.4216936753
MESH:D010146 Pain Acetaminophen 5.7316870215
MESH:D010146 Pain Tretinoin 5.7316870215
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 18.9115580305
MESH:D010190 Pancreatic Neoplasms decitabine 18.9119294695
MESH:D010190 Pancreatic Neoplasms Mitomycin 18.9115113037
MESH:D010190 Pancreatic Neoplasms Phenobarbital 18.9116965848
MESH:D010190 Pancreatic Neoplasms Quercetin 18.9116965848
MESH:D010190 Pancreatic Neoplasms Tretinoin 18.9115976015
MESH:D010212 Papilloma Hydrogen Peroxide 3.7712065085
MESH:D010235 Paraganglioma arsenic trioxide 3.8619927285
MESH:D010300 Parkinson Disease Atrazine 5.4717218051
MESH:D010300 Parkinson Disease Manganese 5.4711181820
MESH:D020734 Parkinsonian Disorders Manganese 4.1916140633
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 3.9212520081
MESH:D010954 Plasmacytoma Selenium 4.5615087411
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.2518163543
MESH:D011230 Precancerous Conditions Phenobarbital 8.352563599
MESH:D011230 Precancerous Conditions Quercetin 8.3519056647
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 2.8711896295 11222880 11399792 11118676
MESH:D055728 Primary Myelofibrosis decitabine 4.4117616702
MESH:D011470 Prostatic Hyperplasia Calcitriol 4.4515572423
MESH:D011471 Prostatic Neoplasms arsenic trioxide 2.2319131511
MESH:D011471 Prostatic Neoplasms Calcitriol 2.2315754350 16644109 16289102 12479363 18247401
MESH:D011471 Prostatic Neoplasms Quercetin 2.2314715546 17292933
MESH:D011471 Prostatic Neoplasms vorinostat 2.2317218635
MESH:D011507 Proteinuria Tretinoin 3.3116636307
MESH:D019310 Pseudolymphoma Phenobarbital 4.1612752131
MESH:D011625 Pterygium Tretinoin 4.4716723453
MESH:D011658 Pulmonary Fibrosis Amiodarone 2.7312490602 12832656 11597910
MESH:D015427 Reperfusion Injury pirinixic acid 2.2319058328
MESH:D012135 Respiratory Sounds Atrazine 4.2011874814
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.5318990726
MESH:D012208 Rhabdomyosarcoma decitabine 9.9519155313
MESH:D012208 Rhabdomyosarcoma Tretinoin 9.9516116481 16283617
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 3.6516646077
MESH:D012554 Schistosomiasis japonica Quercetin 5.2116862918
MESH:D012640 Seizures Phenobarbital 2.484039156 11442880 16876388 3137016
MESH:D003294 Seizures, Febrile Phenobarbital 4.506407741
OMIM:609620 SHORT QT SYNDROME 1 Amiodarone 4.7618724381
MESH:D012878 Skin Neoplasms Hydrogen Peroxide 12.2812065085
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 12.288532709
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 12.2816192470
MESH:D012878 Skin Neoplasms Tretinoin 12.2816467112
MESH:D013272 Stomach Diseases Omeprazole 4.2918545984
MESH:D013274 Stomach Neoplasms arsenic trioxide 3.2217007042
MESH:D013274 Stomach Neoplasms decitabine 3.2219037991
MESH:D013274 Stomach Neoplasms Tretinoin 3.2217261132
MESH:D013276 Stomach Ulcer Amiodarone 6.6318087811
MESH:D013276 Stomach Ulcer Omeprazole 6.6318237397 15991576 10750652 16755016 17977527 11906479
MESH:D013610 Tachycardia Amiodarone 3.9811238279
MESH:D017180 Tachycardia, Ventricular Amiodarone 3.8819225199
MESH:D013921 Thrombocytopenia vorinostat 4.6920479100
MESH:D013959 Thyroid Diseases Amiodarone 10.9519731979
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 10.9512697716
MESH:D013964 Thyroid Neoplasms arsenic trioxide 19.8819014326
MESH:D013964 Thyroid Neoplasms decitabine 19.8817967635
MESH:D013964 Thyroid Neoplasms Phenobarbital 19.881399818
MESH:D013964 Thyroid Neoplasms Propylthiouracil 19.8815710170
MESH:D013964 Thyroid Neoplasms Tretinoin 19.8816026305 17045167
MESH:D013971 Thyrotoxicosis Amiodarone 4.5419584973 18020914
MESH:D014062 Tongue Neoplasms Tretinoin 3.5116051514
MESH:D016171 Torsades de Pointes Amiodarone 9.1817467628 11989578
MESH:D016171 Torsades de Pointes arsenic trioxide 9.1815213294
MESH:D014376 Tuberculosis Tretinoin 3.0316040207
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 7.6620435036 11780464 12973940 12845720
MESH:D001749 Urinary Bladder Neoplasms decitabine 7.6619087683 17616700
MESH:D001749 Urinary Bladder Neoplasms Quercetin 7.6616720314
MESH:D014581 Urticaria Acetaminophen 2.6810982225
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 3.4016129372
MESH:D014604 Uveal Neoplasms decitabine 11.7217785578
MESH:D014604 Uveal Neoplasms Tretinoin 11.7216752155
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.2612125929
MESH:D014820 Vitiligo Tretinoin 3.7516761959
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 3.9215886252
MESH:D009396 Wilms Tumor Tretinoin 3.6916287080
Pathway ID Pathway Name
KEGG:04520 Adherens junction
KEGG:05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC)
KEGG:05100 Bacterial invasion of epithelial cells
REACT:20676 Cell junction organization
KEGG:05213 Endometrial cancer
KEGG:04670 Leukocyte transendothelial migration
REACT:21303 Myogenesis
KEGG:05200 Pathways in cancer
KEGG:04530 Tight junction
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA27008
    • No data
    Releated disease ID Related disease Name
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    Releated drug ID Related drug Name
    PA448976choline
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB03684 - 2-Methyl-2,4-Pentanediol
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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