AutismKB 2.0

Annotation Detail for CTNNA2


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Basic Information Top
Gene Symbol:CTNNA2 ( CAP-R,CAPR,CT114,CTNR,DKFZp686H02198 )
Gene Full Name: catenin (cadherin-associated protein), alpha 2
Band: 2p12
Quick LinksEntrez ID:1496; OMIM: 114025; Uniprot ID:CTNA2_HUMAN; ENSEMBL ID: ENSG00000066032; HGNC ID: 2510
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04670Leukocyte transendothelial migration
hsa05412Arrhythmogenic right ventricular cardiomyopathy (ARVC)
hsa04530Tight junction
hsa05100Bacterial invasion of epithelial cells
hsa04520Adherens junction
hsa05213Endometrial cancer
hsa05200Pathways in cancer
Pathway IDPathway Name
Myogenesis
No data
Pathway IDPathway Name
P00004Alzheimer disease-presenilin pathway
P00012Cadherin signaling pathway
P00057Wnt signaling pathway
No data
Related Diseases/Disorders Top
No data
No data
Desease Name
bipolar disorder
protein quantitative trait loci
CHEMDEPENDENCY
PSYCH
smoking cessation
Desease Name
Protein quantitative trait loci
Bipolar disorder
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene results in increased expression of CTNNA2 mRNAincreases expression 20406850
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in increased expression of CTNNA2 mRNAincreases expression 18648102
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of CTNNA2 mRNAincreases expression 17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CTNNA2 mRNAaffects cotreatment|increases expression 17942748
D009151 Mustard Gas Mustard Gas results in increased expression of CTNNA2 mRNAincreases expression 15674843
D010126 Ozone Ozone results in decreased expression of CTNNA2 mRNAdecreases expression 12763052
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CTNNA2 mRNAaffects cotreatment|increases expression 17942748
D014212 Tretinoin Tretinoin affects the expression of CTNNA2 mRNAaffects expression 16211290
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.2414514962 15322242 11752688
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.3817505938
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.8614692618
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 2.903712494
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.7716835633
MESH:D000505 Alopecia Tretinoin 3.8415955085
MESH:D000544 Alzheimer Disease Ozone 2.4815513908
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.2111748828
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.8211256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 7.7315885639
MESH:D001169 Arthritis, Experimental Tretinoin 7.7316412693
MESH:D001172 Arthritis, Rheumatoid Ozone 4.8515570426
MESH:D001172 Arthritis, Rheumatoid Tretinoin 4.8516292516
MESH:D001249 Asthma Mustard Gas 8.3810378619
MESH:D001249 Asthma Ozone 8.3817854713 16373670
MESH:D001249 Asthma Tretinoin 8.3816456186
MESH:D001471 Barrett Esophagus Tretinoin 4.7316935849
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.461440618 11289319
MESH:D001768 Blister Mustard Gas 5.5619167455
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 9.8912125929
MESH:D001778 Blood Coagulation Disorders Tretinoin 9.8916206674 16197459
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.2315340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.9315746008
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9620435547
MESH:D001943 Breast Neoplasms Tretinoin 1.9616873071 16443354 16166294
MESH:D016535 Bronchial Hyperreactivity Ozone 3.9016777450 18315731 14754758 15516495 17626835 19059883 18417511
MESH:D001989 Bronchiolitis Obliterans Mustard Gas 5.5615286001
MESH:D029481 Bronchitis, Chronic Mustard Gas 5.4217687719 10378619
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.9916813970
MESH:D002100 Cachexia Ozone 5.1416183385
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 3.0216835633
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.6016168501
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 4.7816705839
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 4.783581430 7296757
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 4.781917145
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.787296757
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 2.3516096774 16051514
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.5018850075 18670907 16120746
MESH:D002386 Cataract Tretinoin 3.2417460283
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 7.276135515
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 7.277505956
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.9916129372
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.4116835633
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 8.549022650 19486331
MESH:D002779 Cholestasis Ethinyl Estradiol 8.5417110522 11677210 15861022 16919318 17333356 17681005 16105132
MESH:D002822 Choriocarcinoma Tretinoin 5.6016461808
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 6.0916354765 8697196 12621046 15340226 15668235
MESH:D002972 Cleft Palate Tretinoin 6.099407595
MESH:D003092 Colitis Tretinoin 4.0617035595
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.3114669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.5110048152 15322242 20055451
MESH:D019465 Craniofacial Abnormalities Tretinoin 2.5110589399 9142499 9125849 9224671 8800419 16925845 9664655 9211117 17551590 14991402
MESH:D003490 Cyanosis 2,6-dinitrotoluene 4.3818551238
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 3.1518759878 2524372 11298694 8156756 8970840 12868966 11906362 14531868
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.792952479 3621924
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7217107852
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 6.5721346803 18551238
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 6.5718289764 9328219 18648102 8291058 11289319 6679447 6482804 1440618 18692083 9022650 9653073 7440962 16192314
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 6.5720420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.9611462148
MESH:D004487 Edema Mustard Gas 7.7911428631 9260866 11428647 11402378
MESH:D004487 Edema Tetrachlorodibenzodioxin 7.7911000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 13.4716714409 15322242 18230668
MESH:D004489 Edema, Cardiac Tretinoin 13.4718230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.5212538720
MESH:D016889 Endometrial Neoplasms Tretinoin 3.2816569247
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.299294722 10568697
MESH:D004890 Erythema Mustard Gas 5.569357497
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 2.163581430
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 9.5211564622
MESH:D005124 Eye Abnormalities Tretinoin 9.529664655 16938888
MESH:D005234 Fatty Liver Ethinyl Estradiol 3.0915345470
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.8111858732
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.466705139
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 9.8420067830
MESH:D005355 Fibrosis Tretinoin 9.8417994277
MESH:D005909 Glioblastoma Tretinoin 3.1717312396
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.347505956
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 5.0410696789
MESH:D006258 Head and Neck Neoplasms Tretinoin 3.3616096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.6016084493
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.9710048152 11294989
MESH:D006330 Heart Defects, Congenital Tretinoin 6.9714991402 9664655
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.6211000095
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.846705139
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.2512621046 15340226 16120746
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.4916959395 15340226 16354765 18606429 8697196
MESH:D006930 Hyperalgesia Tretinoin 3.4316870215
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.9316778211
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.3015034207
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9918850075 18670907
MESH:D007021 Hypospadias Ethinyl Estradiol 4.1716569931 16945680
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.7712013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.6617937319
MESH:D007249 Inflammation Mustard Gas 5.4811428620 11428647 8975870 9357497 17524151 16001271 9260866 11402378 11428631
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 5.4812878042 12200463
MESH:D007410 Intestinal Diseases Tretinoin 4.1217994277
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.468074119 9022650
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 10.8916580747
MESH:D007569 Jaw Abnormalities Tretinoin 10.8915992940 17551590
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 8.1516705839
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 8.156582329
MESH:D007938 Leukemia Tretinoin 2.8917143497
MESH:D007951 Leukemia, Myeloid Tretinoin 3.9816482212 16932348 19285840
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 2.1116294345 17596541 19850784
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 3.3216140955 17361223 19642359 19075265 17107899 16823087 19035177 12679006 19225113 17712046 17217047 17339181 16766008 17294898 15748426 16891316 16331271 17506722 17368321 16788101 17301526 17649720 19029980 9834237 16935935
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.509224671
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.359327722 15034207
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.3712878042
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 2.3718397230 16248980
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 4.667678174
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 4.6616984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 10.726135515 2876786 2876784
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 10.723712494 6587162 598648 1399818
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 10.7212151625
MESH:D008171 Lung Diseases Mustard Gas 8.2118161513 18702808
MESH:D008171 Lung Diseases Ozone 8.2119066396 8266340
MESH:D055370 Lung Injury Ozone 4.2120417186
MESH:D008175 Lung Neoplasms Mustard Gas 3.613148597 8781369
MESH:D008175 Lung Neoplasms Ozone 3.618597069 7614698
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.6119555203 11884234
MESH:D008527 Medulloblastoma Tretinoin 2.8717453147
MESH:D008545 Melanoma Tretinoin 1.9716752155
MESH:D008591 Meningomyelocele Tretinoin 4.7816940565
MESH:D008679 Metaplasia Ozone 5.5510496685
MESH:D009190 Myelodysplastic Syndromes Tretinoin 3.2217596541
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.2412213967
MESH:D009336 Necrosis 2,6-dinitrotoluene 4.267678174 18551238
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 2.563581430
MESH:D009369 Neoplasms Tretinoin 2.5216946489 16594593
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 10.6314600291
MESH:D009421 Nervous System Malformations Tretinoin 10.639125849
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 7.806679447
MESH:D009436 Neural Tube Defects Tretinoin 7.809142499
MESH:D009503 Neutropenia Mustard Gas 4.277688884 16761898
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 9.7816049721
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 9.784026338 6482804
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.463988306
MESH:D010051 Ovarian Neoplasms Tretinoin 2.4116936753
MESH:D010146 Pain Tretinoin 3.1316870215
MESH:D010190 Pancreatic Neoplasms Tretinoin 2.5415976015
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.9911578682
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.847296757
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.6912520081
MESH:D010538 Peritonitis Ozone 4.4916369182
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.916228378
MESH:D011014 Pneumonia Ozone 4.7918929643 18381685 18007984
MESH:D011041 Poisoning Mustard Gas 4.1015727166
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.8918163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.5911896295 11399792 11118676 11222880
MESH:D011507 Proteinuria Tretinoin 3.9116636307
MESH:D011537 Pruritus Ethinyl Estradiol 10.8815861022 16919318
MESH:D011537 Pruritus Mustard Gas 10.8818058305
MESH:D011625 Pterygium Tretinoin 5.1916723453
MESH:D011658 Pulmonary Fibrosis Mustard Gas 3.0117720292 17266442 17620002 17894541 10334151
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.1718990726
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.583692021
MESH:D012208 Rhabdomyosarcoma Tretinoin 4.4016283617 16116481
MESH:D012640 Seizures 2,6-dinitrotoluene 2.7118551238
MESH:D012871 Skin Diseases Mustard Gas 2.7712880345 15451306 16961503
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.9416192470
MESH:D012878 Skin Neoplasms Tretinoin 5.9416467112
MESH:D013088 Spermatocele Ethinyl Estradiol 4.3816709447
MESH:D013274 Stomach Neoplasms Tretinoin 1.8017261132
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.9211994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.4015669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.3512697716
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 7.846582329 6587162 1399818 7505956 3712494
MESH:D013964 Thyroid Neoplasms Tretinoin 7.8417045167 16026305
MESH:D014062 Tongue Neoplasms Tretinoin 4.0516051514
MESH:D014376 Tuberculosis Tretinoin 3.3816040207
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 5.3116049721
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 5.318074119
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 4.7110091137
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 3.9416129372
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.6314692618
MESH:D014604 Uveal Neoplasms Tretinoin 5.0516752155
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 5.0412125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.8215869587 14671159
MESH:D014820 Vitiligo Tretinoin 4.3916761959
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.6915886252
MESH:D009396 Wilms Tumor Tretinoin 4.2216287080
Pathway ID Pathway Name
KEGG:04520 Adherens junction
KEGG:05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC)
KEGG:05100 Bacterial invasion of epithelial cells
KEGG:05213 Endometrial cancer
KEGG:04670 Leukocyte transendothelial migration
REACT:21303 Myogenesis
KEGG:05200 Pathways in cancer
KEGG:04530 Tight junction
Pharmacogenomics Knowledge Base Top
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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