AutismKB 2.0

Annotation Detail for AANAT


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Basic Information Top
Gene Symbol:AANAT ( SNAT )
Gene Full Name: aralkylamine N-acetyltransferase
Band: 17q25.1
Quick LinksEntrez ID:15; OMIM: 600950; Uniprot ID:SNAT_HUMAN; ENSEMBL ID: ENSG00000129673; HGNC ID: 19
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Pathway IDPathway Name
PWY-6030serotonin and melatonin biosynthesis
Pathway IDPathway Name
hsa00380Tryptophan metabolism
hsa01100Metabolic pathways
Pathway IDPathway Name
Hormone biosynthesis
Metabolism of amino acids and derivatives
No data
No data
Pathway IDPathway Name
500767Serotonin and melatonin biosynthesis
Related Diseases/Disorders Top
No data
No data
Desease Name
NEUROLOGICAL
delayed sleep phase syndrome
No data
Desease Name
Delayed sleep phase syndrome, susceptibility to
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000643 Ammonium Chloride Ammonium Chloride affects the expression of AANAT mRNAaffects expression 16483693
C055494 caffeic acid phenethyl ester [Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of AANAT mRNAaffects cotreatment|decreases expression 20360939
C059041 calyculin A calyculin A results in decreased activity of AANAT proteindecreases activity 11442772
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of AANAT mRNAaffects cotreatment|decreases expression 20360939
D012701 Serotonin AANAT protein binds to and results in increased acylation of Serotoninaffects binding|increases acylation 15644438
D008094 Lithium Lithium inhibits the reaction [Methamphetamine results in decreased expression of AANAT mRNA]decreases expression|decreases reaction 19149911
D008694 Methamphetamine Lithium inhibits the reaction [Methamphetamine results in decreased expression of AANAT mRNA]decreases expression|decreases reaction 19149911
D008694 Methamphetamine Methamphetamine results in decreased expression of AANAT mRNAdecreases expression 19149911
D008694 Methamphetamine Valproic Acid inhibits the reaction [Methamphetamine results in decreased expression of AANAT mRNA]decreases expression|decreases reaction 19149911
D019319 Okadaic Acid Okadaic Acid results in decreased activity of AANAT proteindecreases activity 11442772
D019319 Okadaic Acid Okadaic Acid results in decreased expression of AANAT mRNAdecreases expression 11442772
D014501 Uranium Uranium affects the expression of AANAT mRNAaffects expression 15672453
C005460 uranyl acetate uranyl acetate affects the expression of AANAT mRNAaffects expression 15672453
D014635 Valproic Acid Valproic Acid inhibits the reaction [Methamphetamine results in decreased expression of AANAT mRNA]decreases expression|decreases reaction 19149911
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 3.688875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 4.0719490988
MESH:D000138 Acidosis Ammonium Chloride 3.7518287403
MESH:D000236 Adenoma Diethylnitrosamine 2.9310737359 6695378
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 4.0918056438 19061943 17162532 19052882 17620307 16434500
MESH:D000544 Alzheimer Disease Lithium 3.4919621015
MESH:D000550 Amblyopia Valproic Acid 5.4517688650
MESH:D001008 Anxiety Disorders Valproic Acid 3.6817497229
MESH:D001321 Autistic Disorder Serotonin 2.6118062943 8570775 18361446 15132762 17157402 18405062 19221690
MESH:D001321 Autistic Disorder Valproic Acid 2.6117507914 18985861 17157402 18558336 17688650 15238991 18940202 18316065 16609825 18396377 18775368 19460635 20603192 19232924 18177632
MESH:D001714 Bipolar Disorder Lithium 7.8320046352 19153942 20338123 17594078
MESH:D001714 Bipolar Disorder Valproic Acid 7.8320046352 17594078
MESH:D001848 Bone Diseases, Developmental Valproic Acid 3.498888407
MESH:D001919 Bradycardia Serotonin 5.678112388
MESH:D001943 Breast Neoplasms Diethylnitrosamine 2.2217474063
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 1.8618971187 20514400 11831363 18506893 16779866 19519916 21159647 16288022 20512989 20935162 19822196 17428255 19418558 10672840 20084675 18785209 10737359 19335982 18665156 16807293 16681979 3581430 18691550 17761372 18056438 17173139 20524982 18393292 20007298 18210153 20432363 3084413 18788625 19701751 19383236 19394651 16540662 17978847 16328049 19539802 16935385 19171122 16569478 19052882 19107877 17138121 16698587 18494052 16830150 20214788 16878318 18978308 17055752 20727157 20101231 19919837 16502159 17162532 19208518
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 2.9521159647 7505956 2727394 17174075
MESH:D002659 Child Development Disorders, Pervasive Serotonin 6.5921254450
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 6.5920734317
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 3.8119052882
MESH:D021081 Chronobiology Disorders Serotonin 6.9117157402
MESH:D019465 Craniofacial Abnormalities Valproic Acid 1.908888407 16575769 17688650
MESH:D007644 Darier Disease Lithium 6.1020338123
MESH:D018500 Diabetes Insipidus, Nephrogenic Lithium 5.9219244398
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 2.2220387270
MESH:D003967 Diarrhea Serotonin 4.938112388 11488427 10446763
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 4.0819107877
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 4.081733752 19641884
MESH:D004421 Dystonia Valproic Acid 4.201851702
MESH:D004487 Edema Serotonin 4.6118841975
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 4.3317275665 3659116
MESH:D004828 Epilepsies, Partial Valproic Acid 4.133922381 16628512
MESH:D004827 Epilepsy Valproic Acid 3.0020417680 18234410
MESH:D004832 Epilepsy, Absence Valproic Acid 3.716254150 6426943 7562514
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 4.477750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 4.263659116
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.3316302075
MESH:D005234 Fatty Liver Diethylnitrosamine 8.3521071580 20387270
MESH:D005234 Fatty Liver Valproic Acid 8.3519224547 14986274
MESH:D005315 Fetal Diseases Valproic Acid 5.1016575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 4.298888407 18558336
MESH:D005909 Glioblastoma Okadaic Acid 4.7117312396
MESH:D006330 Heart Defects, Congenital Lithium 4.2819638421
MESH:D006849 Hydrocephalus Valproic Acid 5.0617688650
MESH:D006948 Hyperkinesis Methamphetamine 5.7017658665
MESH:D007249 Inflammation Diethylnitrosamine 2.4418785209
MESH:D007414 Intestinal Neoplasms caffeic acid phenethyl ester 4.7210783313
MESH:D007674 Kidney Diseases caffeic acid phenethyl ester 3.6215369732
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 2.1717596541 16294345
MESH:D015473 Leukemia, Promyelocytic, Acute caffeic acid phenethyl ester 4.0816766008
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 2.8918665156 18522880 20032147 18407596 19638242
MESH:D008107 Liver Diseases Diethylnitrosamine 2.1317034775
MESH:D008113 Liver Neoplasms Diethylnitrosamine 2.2819254457 19256749 19255062 18644402 19996281 18754104 18648771 19833225 21167192 19690152 19294768 19426721 15885732 19812893 20583210 20137499 15175105 12112319 18977376 19638242 20101389 20405173 19090486 10737359 19073162 21047994 2422723 21278145 19642983 19499222 21071580 12771043 19551842 20452335 20118626 9163691 18978307 20492335 19850985 20434301 20501860 2862719 16942905 19427195
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 2.7118079962 18253720 18093689 2563599 3124819 9362446 18544905 17174075 18775883 17854601 17942915 19126423 19009564 19004024 18282651 19519916 16842330 18164116 18308698 19539802 16267830 21159647
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 4.4817228818
MESH:D008175 Lung Neoplasms Diethylnitrosamine 1.7620970405 21163286 6695378 20512841
MESH:D008881 Migraine Disorders Valproic Acid 3.2918803445 18765137
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 4.178888407
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 3.2317596541
MESH:D009203 Myocardial Infarction Lithium 3.9716288908
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 2.619029167 3581430
MESH:D009436 Neural Tube Defects Valproic Acid 3.2116359493 8888407
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 3.4620387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.3320387270
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 2.4616540662
MESH:D011230 Precancerous Conditions Diethylnitrosamine 3.682563599
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 4.0220603192
MESH:D019310 Pseudolymphoma Valproic Acid 4.7612752131 11422049
MESH:D012208 Rhabdomyosarcoma Valproic Acid 4.3219155313
MESH:D012559 Schizophrenia Valproic Acid 2.0815737665 19110320
MESH:D012640 Seizures Lithium 6.7919660546
MESH:D012640 Seizures Valproic Acid 6.7911738929 14763951 15475178 16876388 17978042 11044598 3137016 1511512
MESH:D012878 Skin Neoplasms Okadaic Acid 4.2912628509
MESH:D012893 Sleep Disorders marker/mechanism
MESH:D016135 Spinal Dysraphism Valproic Acid 3.8919490988
MESH:D013226 Status Epilepticus Lithium 13.4019951488 19430551 19570321
MESH:D013226 Status Epilepticus Valproic Acid 13.4012833885
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 1.7618456281
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 3.097505956
MESH:D014178 Translocation, Genetic Valproic Acid 5.4517262798
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.713119515
MESH:D014564 Urogenital Abnormalities Valproic Acid 4.828888407
Pathway ID Pathway Name
REACT:15314 Hormone biosynthesis
KEGG:01100 Metabolic pathways
REACT:13 Metabolism of amino acids and derivatives
KEGG:00380 Tryptophan metabolism
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA24366
    • No data
    No data
    Releated drug ID Related drug Name
    PA161990676tetrahydrobiopterin
    PA10323l-tryptophan
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB01777 - Coa-S-Trimethylene-Acetyl-Tryptamine
    DB02931 - Coa-S-Acetyl Tryptamine
    DB03341 - Coa-S-Acetyl 5-Bromotryptamine
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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