AutismKB 2.0

Annotation Detail for SIK1


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Basic Information Top
Gene Symbol:SIK1 ( MSK,SIK,SNF1LK )
Gene Full Name: salt-inducible kinase 1
Band: 21q22.3
Quick LinksEntrez ID:150094; OMIM: 605705; Uniprot ID:SIK1_HUMAN; ENSEMBL ID: ENSG00000142178; HGNC ID: 11142
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
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Pathway IDPathway Name
200061LKB1 signaling events
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Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C548651 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in decreased expression of SIK1 mRNAdecreases expression 19933214
C404910 2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane 2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane affects the reaction [FSHB protein affects the expression of SIK1 mRNA]affects expression|affects reaction 19414516
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of SIK1 mRNAaffects expression 21346803
C021296 2-ethoxyethanol 2-ethoxyethanol results in increased expression of SIK1 mRNAincreases expression 19643169
D000082 Acetaminophen Acetaminophen affects the expression of SIK1 mRNAaffects expression 17562736
D000643 Ammonium Chloride Ammonium Chloride affects the expression of SIK1 mRNAaffects expression 16483693
D000965 Antimony Antimony results in increased expression of SIK1 mRNAincreases expression 17547211
D000966 Antimony Potassium Tartrate Antimony Potassium Tartrate results in increased expression of SIK1 mRNAincreases expression 17547211
D016589 Astemizole Astemizole results in decreased expression of SIK1 mRNAdecreases expression 20221588
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide affects the expression of SIK1 mRNAaffects expression 20382639
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of SIK1 mRNAdecreases expression 19150397
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in increased expression of SIK1 mRNAincreases expression 15336504
D002857 Chromium Chromium results in increased expression of SIK1 mRNAincreases expression 17547211
D016572 Cyclosporine Cyclosporine results in increased expression of SIK1 mRNAincreases expression 20106945
D004128 Dimethylnitrosamine Dimethylnitrosamine results in increased expression of SIK1 mRNAincreases expression 17547211
D004317 Doxorubicin Doxorubicin results in increased expression of SIK1 mRNAincreases expression 16243910
C022838 nickel chloride nickel chloride results in increased expression of SIK1 mRNAincreases expression 17547211
D019800 Phenol Phenol results in increased expression of SIK1 mRNAincreases expression 17547211
D010656 Phenylephrine Phenylephrine results in increased expression of SIK1 mRNAincreases expression 18158353
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of SIK1 mRNAaffects binding|decreases expression|increases activity 19710929
D011192 Potassium Dichromate Potassium Dichromate results in increased expression of SIK1 mRNAincreases expression 17547211
C009250 sevoflurane sevoflurane affects the expression of SIK1 mRNAaffects expression 15967596
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of SIK1 mRNAdecreases expression 19933214
C025643 vinclozolin vinclozolin affects the expression of SIK1 mRNAaffects expression 19015723
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced 2-ethoxyethanol 8.286499823 6499796 6499812 7151721 6499820
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 8.2814514962 11752688 15322242
MESH:D000138 Acidosis Ammonium Chloride 3.4118287403
MESH:D055371 Acute Lung Injury pirinixic acid 2.9718653653
MESH:D000230 Adenocarcinoma Dimethylnitrosamine 4.6616033868
MESH:D000230 Adenocarcinoma Doxorubicin 4.6617418594
MESH:D000236 Adenoma Dimethylnitrosamine 3.4719555203
MESH:D018248 Adenoma, Liver Cell pirinixic acid 9.3916434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 9.3916835633
MESH:D000419 Albuminuria Doxorubicin 4.4021441931
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.8111748828
MESH:D000799 Angioedema Acetaminophen 11.5210982225
MESH:D000799 Angioedema Astemizole 11.522883202
MESH:D001008 Anxiety Disorders vinclozolin 3.5219015723
MESH:D001145 Arrhythmias, Cardiac Phenylephrine 3.9817460149
MESH:D053627 Asthenozoospermia 2-ethoxyethanol 5.546499807 6499823 10689203
MESH:D001259 Ataxia 2-ethoxyethanol 5.317151721
MESH:D001284 Atrophy 2-ethoxyethanol 5.2015850284 6499799
MESH:D001321 Autistic Disorder Acetaminophen 1.4318445737
MESH:D053713 Azoospermia 2-ethoxyethanol 5.436499807 6492198
MESH:D001724 Birth Weight 2-ethoxyethanol 6.366499823 2884743
MESH:D001778 Blood Coagulation Disorders pirinixic acid 8.3119483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 8.3112125929
MESH:D001836 Body Weight Changes 2-ethoxyethanol 11.527151721 6499796
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 11.5215340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.6715746008
MESH:D019046 Bone Marrow Neoplasms Doxorubicin 4.5514601052
MESH:D001859 Bone Neoplasms Phenol 5.0610556009
MESH:D001913 Bowen's Disease Phenol 5.6019293009
MESH:D001919 Bradycardia Phenylephrine 4.3915306635
MESH:D001932 Brain Neoplasms Doxorubicin 3.6817150277
MESH:D001943 Breast Neoplasms Chromium 2.0515986119
MESH:D001943 Breast Neoplasms Doxorubicin 2.0516935488 17369602 16264153 15668708 16322301 11325840 15567936 15994142 15692762 18382427 18628466 16826403 18695136 17983394 16595493 18234424 17426702 16115903 16096432 19526202 15634643 15939500 15136595 15993339
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.0520435547
MESH:D001991 Bronchitis Antimony 5.988768112
MESH:D002276 Carcinoid Tumor Doxorubicin 4.6616051944
MESH:D002277 Carcinoma Dimethylnitrosamine 7.9519555203
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 7.9516835633
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 4.4316705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 4.433084413
MESH:D006528 Carcinoma, Hepatocellular Doxorubicin 4.4318059187 17876044 16023760 16234567
MESH:D002292 Carcinoma, Renal Cell Doxorubicin 3.091485588 16201981
MESH:D002294 Carcinoma, Squamous Cell Dimethylnitrosamine 4.8816033868
MESH:D002294 Carcinoma, Squamous Cell Doxorubicin 4.886189445
MESH:D006332 Cardiomegaly Phenylephrine 6.6017287366 11754973 16170337 11179087 17124262 15728586
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 6.6018850075 18670907 16120746
MESH:D009202 Cardiomyopathies Doxorubicin 3.4315505089 16278810 15792986 16612575 15811867 17308081 16731534 17928571 16109756 16242529 16651473 16455267 18627295 17131338 17351982 17924179 16269455 17007740 17382496 16364871 17519947 17329180 17974986 16952015 15476868
MESH:D002311 Cardiomyopathy, Dilated marker/mechanism 16243910
MESH:D002311 Cardiomyopathy, Dilated Antimony 6.1810334427
MESH:D002311 Cardiomyopathy, Dilated Doxorubicin 6.1816243910 17334414
MESH:D002386 Cataract Acetaminophen 2.4910977129
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 10.536135515
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 10.5320889678
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 10.5312371664
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.0316835633
MESH:D002764 Cholecystitis 2-ethoxyethanol 5.816499794
MESH:D002779 Cholestasis Cyclosporine 7.3919486331
MESH:D002779 Cholestasis pirinixic acid 7.3919176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.048697196 15668235 12621046 16354765 15340226
MESH:D015179 Colorectal Neoplasms Doxorubicin 2.1418259882 18802399
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.9314669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2510048152 20055451 15322242
MESH:D003456 Cryptorchidism vinclozolin 4.1914966744
MESH:D003490 Cyanosis 2,6-dinitrotoluene 3.8718551238
MESH:D003643 Death 2-ethoxyethanol 5.816499796
MESH:D017449 Dermatitis, Allergic Contact Potassium Dichromate 4.1616823706
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.3618249437
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6317107852
MESH:D004244 Dizziness Astemizole 6.313105558
MESH:D004283 Dog Diseases Antimony 5.5012019027
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 11.5418551238 21346803
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 11.5418713872 11529661 19420014 12540782 11834606 12958197 16393943 11421492 11739529 19739265 17562736 17906064 10774834 16781746 19164858 11287661 16109766 10915739 14986274 14725611 12594235 12705907 10663392 11461765 15968718 17522070 19085960 14550746 16485898 19416960 12392966 18071297 12153990 11743745 16177239 16081117 2444490 19370779 19923254 16227642 15619225
MESH:D056486 Drug-Induced Liver Injury Dimethylnitrosamine 11.548172417
MESH:D056486 Drug-Induced Liver Injury Doxorubicin 11.5417416283
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 11.5420420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.9519426721
MESH:D004362 Drug Toxicity Doxorubicin 7.7418602426
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 7.7411462148
MESH:D004487 Edema pirinixic acid 6.0812083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 6.0811000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.7518230668 15322242 16714409
MESH:D020964 Embryo Loss 2-ethoxyethanol 6.366499796
MESH:D016889 Endometrial Neoplasms Doxorubicin 3.3517359293
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.899294722 10568697
MESH:D004719 Endomyocardial Fibrosis Doxorubicin 5.0118037988
MESH:D004802 Eosinophilia Astemizole 4.651355641
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 4.5520426865
MESH:D004938 Esophageal Neoplasms Dimethylnitrosamine 4.5517016578
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.9011564622
MESH:D005234 Fatty Liver Cyclosporine 7.1019224547
MESH:D005234 Fatty Liver pirinixic acid 7.1020131406 19236843
MESH:D005313 Fetal Death 2-ethoxyethanol 10.346499823 7198755 2884743 7151721 6499820
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 10.3411858732
MESH:D005317 Fetal Growth Retardation 2-ethoxyethanol 5.266499796
MESH:D005327 Fetal Resorption 2-ethoxyethanol 5.566499812 6499820
MESH:D020567 Fetal Weight 2-ethoxyethanol 5.816499820 2884743 7151721
MESH:D018222 Fibromatosis, Aggressive Doxorubicin 4.4419069698
MESH:D005355 Fibrosis Cyclosporine 7.9812639820 12168785
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 7.9820067830
MESH:D005499 Folliculitis Astemizole 5.771671328
MESH:D005756 Gastritis Acetaminophen 3.5216983495
MESH:D030342 Genetic Diseases, Inborn vinclozolin 4.7816973722
MESH:D005832 Genital Diseases, Male vinclozolin 5.1516417039
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.078708960
MESH:D005909 Glioblastoma Doxorubicin 3.2517150277
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.4410696789
MESH:D006258 Head and Neck Neoplasms Doxorubicin 3.4315692506
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.2510048152 11294989
MESH:D006331 Heart Diseases Doxorubicin 3.3816144979 17875725 17888722 14766674 16330681 16244372 16707910 18006777 18674790 16495754 16879835 12587719 16244371
MESH:D006333 Heart Failure Doxorubicin 6.7417481944
MESH:D006333 Heart Failure pirinixic acid 6.7420558911
MESH:D006394 Hemangiosarcoma Doxorubicin 3.7615692506
MESH:D006402 Hematologic Diseases 2-ethoxyethanol 5.2420172899 10514026
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.2715720958
MESH:D006461 Hemolysis 2-ethoxyethanol 5.4719051582 17874071
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.2011000095
MESH:D006529 Hepatomegaly pirinixic acid 7.7616221962 19176532 19772884 18467677
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 7.7615340226 12621046 16120746
MESH:D006689 Hodgkin Disease Doxorubicin 3.2815147373 18501091 17606976
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.8916959395 18606429 8697196 15340226 16354765
MESH:D006930 Hyperalgesia Acetaminophen 2.5816870215
MESH:D006943 Hyperglycemia pirinixic acid 3.0520558911
MESH:D006973 Hypertension Cyclosporine 8.2710903974
MESH:D006973 Hypertension Phenylephrine 8.2712717712 8949925
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 8.2718670907 18850075
MESH:D006984 Hypertrophy Phenylephrine 4.4212791704 18502941
MESH:D007247 Infertility, Female 2-ethoxyethanol 5.096499823
MESH:D007248 Infertility, Male 2-ethoxyethanol 6.986499823
MESH:D007248 Infertility, Male vinclozolin 6.9816467254
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 1.7812878042 12200463
MESH:D007333 Insulin Resistance pirinixic acid 2.5316306350
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.2016580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.2915604871
MESH:D055623 Keratosis, Actinic Phenol 6.2919293009
MESH:D007674 Kidney Diseases Acetaminophen 18.1815629191 12587719
MESH:D007674 Kidney Diseases Chromium 18.1817934191
MESH:D007674 Kidney Diseases Cyclosporine 18.188314463 18776723 10903974
MESH:D007674 Kidney Diseases Doxorubicin 18.1816775033 15699352 15369732
MESH:D007674 Kidney Diseases Potassium Dichromate 18.1819665454
MESH:D007676 Kidney Failure, Chronic Doxorubicin 4.0116707910
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 6.8616705839
MESH:D007680 Kidney Neoplasms Cyclosporine 6.8612371664
MESH:D007859 Learning Disorders sevoflurane 4.6219212262
MESH:D007896 Leishmaniasis Antimony 4.6812019027 15220340 21182181 10953559 21063981
MESH:D016773 Leishmaniasis, Cutaneous Antimony 4.5419141829 8889330 11475954
MESH:D007897 Leishmaniasis, Mucocutaneous Antimony 5.3410651420 10881086 9643325 11370249 7854095
MESH:D007898 Leishmaniasis, Visceral Antimony 8.3511105143 7875148 7854095 1899875 20495762 7554475 8142506
MESH:D007898 Leishmaniasis, Visceral Antimony Potassium Tartrate 8.3512707265
MESH:D004915 Leukemia, Erythroblastic, Acute Doxorubicin 5.0116085563
MESH:D015473 Leukemia, Promyelocytic, Acute Antimony Potassium Tartrate 4.429834237
MESH:D007984 Leydig Cell Tumor vinclozolin 4.5816417039
MESH:D017513 Lichen Nitidus Astemizole 6.312563723
MESH:D008106 Liver Cirrhosis, Experimental Dimethylnitrosamine 4.8212918455 15798949 15138612 16627068 15842777 17724770 18672772 15369754 18210741 14643895 15067225 16009107 15086199 15577212 15081153 17198567 15942678 17201889 15793283 14568256 17348192 15479170 17640959 15161499 15763062 15383259 17432682 17534399 16042886 17465448 16570917 15099470 18364076 16169303 16270385 17719030 15298665 15571005 18237412 14726149 12925901 18239293 15339415 18095165 18629640 16544323 17881167 15591649 15366600 18371158 17203207 16603200 17196135 15492853 18637143 14709902 17666798 15744066 18567088 15864749 17036385 15723089 15504291 14659978 15733078
MESH:D008106 Liver Cirrhosis, Experimental Doxorubicin 4.8216595196 16439617
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 4.8215474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 4.8212878042
MESH:D008107 Liver Diseases Acetaminophen 1.5919014921 16611625 12969438 16610002 19784758 12587719 19460945 11587558
MESH:D017114 Liver Failure, Acute Acetaminophen 9.2317185352 16871587
MESH:D017114 Liver Failure, Acute Dimethylnitrosamine 9.2317457977
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 10.237678174
MESH:D008113 Liver Neoplasms Dimethylnitrosamine 10.2315890375 3113478
MESH:D008113 Liver Neoplasms pirinixic acid 10.2315890375 16377806 20007298
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 10.2316984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 13.382876784 2876786 6135515
MESH:D008114 Liver Neoplasms, Experimental Dimethylnitrosamine 13.3815603536 1848544 6150874
MESH:D008114 Liver Neoplasms, Experimental Doxorubicin 13.3816842330 17085340
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 13.3812151625
MESH:D008133 Long QT Syndrome Astemizole 4.4818472280 11989578
MESH:D008175 Lung Neoplasms Dimethylnitrosamine 3.4216061637 11884234 19555203
MESH:D008175 Lung Neoplasms Doxorubicin 3.426189445 17418594
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.4211884234 19555203
MESH:D008223 Lymphoma Doxorubicin 3.3516098063
MESH:D008228 Lymphoma, Non-Hodgkin Doxorubicin 3.6717654614
MESH:D016399 Lymphoma, T-Cell Doxorubicin 4.4215621674
MESH:D008288 Malaria Astemizole 4.6416816845
MESH:D008325 Mammary Neoplasms, Experimental Doxorubicin 2.9415458769
MESH:D008545 Melanoma Doxorubicin 2.2716827129
MESH:D008546 Melanoma, Experimental Acetaminophen 3.4219513568
MESH:D008569 Memory Disorders sevoflurane 4.6019212262
MESH:D008654 Mesothelioma Doxorubicin 3.0017638057
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.6416801185
MESH:D028361 Mitochondrial Diseases Doxorubicin 4.3615792986
MESH:D052016 Mucositis Doxorubicin 4.6417415656
MESH:D009135 Muscular Diseases pirinixic acid 3.3616239165
MESH:D009203 Myocardial Infarction Doxorubicin 5.5015857846 19429709
MESH:D009203 Myocardial Infarction pirinixic acid 5.5019151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.9012213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 2.8316411023
MESH:D009336 Necrosis 2,6-dinitrotoluene 10.3918551238 7678174
MESH:D009336 Necrosis 2-ethoxyethanol 10.3920172899
MESH:D009362 Neoplasm Metastasis Doxorubicin 2.8918259882
MESH:D009369 Neoplasms pirinixic acid 1.8817405874
MESH:D009401 Nephrosis Doxorubicin 4.6216636307 16899518
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.2917954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 8.8719348381 18481113
MESH:D009404 Nephrotic Syndrome Doxorubicin 8.8716889571 15640375
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.0714600291
MESH:D009447 Neuroblastoma Doxorubicin 3.1915555623
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.7518514411
MESH:D009759 Nystagmus, Pathologic Astemizole 6.316135121
MESH:D009765 Obesity pirinixic acid 1.7820558911
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 3.3016049721
MESH:D009845 Oligospermia 2-ethoxyethanol 5.1920172899
MESH:D012516 Osteosarcoma Doxorubicin 3.9915930896
MESH:D010146 Pain Acetaminophen 6.6516870215
MESH:D010146 Pain Phenol 6.6517610455
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.1012520081
MESH:D010392 Pemphigus Phenol 6.2917163923 16522979
MESH:D010409 Penile Diseases Antimony 5.579643325
MESH:D010493 Pericarditis Antimony 5.9620465667
MESH:D003557 Phyllodes Tumor Doxorubicin 5.0117983394
MESH:D010864 Pilonidal Sinus Phenol 6.2915622588 19655223
MESH:D010997 Pleural Neoplasms Doxorubicin 5.0117638057
MESH:D011041 Poisoning Phenol 4.578825745
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.4118163543
MESH:D011230 Precancerous Conditions Cyclosporine 3.0912371664
MESH:D011297 Prenatal Exposure Delayed Effects 2-ethoxyethanol 15.537198755 6499817 2884743
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 15.5311222880 11896295 11118676 11399792
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 15.5318042343 18220299 19015723
MESH:D011469 Prostatic Diseases vinclozolin 4.7818220299
MESH:D011471 Prostatic Neoplasms Doxorubicin 3.6016888761 16868541 18437689 15749863 16729912 15897917
MESH:D011472 Prostatitis vinclozolin 4.7818629315
MESH:D011565 Psoriasis Cyclosporine 2.1816882103
MESH:D051437 Renal Insufficiency Doxorubicin 4.0717922066
MESH:D015427 Reperfusion Injury pirinixic acid 2.3119058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.6918990726
MESH:D012221 Rhinitis, Allergic, Perennial Astemizole 5.2810822083
MESH:D012509 Sarcoma Doxorubicin 3.8616767912 15625365 17203757 15675481 18313854 17710206
MESH:D012512 Sarcoma, Ewing's Doxorubicin 4.0916326096 14601052
MESH:D012514 Sarcoma, Kaposi Doxorubicin 4.6417846226
MESH:D012640 Seizures 2,6-dinitrotoluene 2.4418551238
MESH:D012852 Sinusitis Phenylephrine 4.557327846
MESH:D012878 Skin Neoplasms Doxorubicin 9.0615692506
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 9.068532709
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 9.0616192470
MESH:D012983 Soft Tissue Neoplasms Doxorubicin 4.4215625365 17203757 16767912
MESH:D013088 Spermatocele Phenol 5.4918646496
MESH:D013158 Splenic Diseases Dimethylnitrosamine 5.1212587719
MESH:D013274 Stomach Neoplasms Dimethylnitrosamine 2.4516033868
MESH:D013276 Stomach Ulcer 2-ethoxyethanol 4.256499799
MESH:D013733 Testicular Diseases 2-ethoxyethanol 5.1010514026 10048760 6499806
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.7512697716
MESH:D013964 Thyroid Neoplasms Doxorubicin 3.2616010429 17909728
MESH:D016171 Torsades de Pointes Astemizole 5.058256756 9583453
MESH:D014277 Trigeminal Neuralgia Phenol 6.2910223447 16527771
MESH:D014352 Trypanosomiasis Antimony 5.7815220340
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 4.9916049721
MESH:D001749 Urinary Bladder Neoplasms Doxorubicin 4.9917653716
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 4.1710091137
MESH:D014581 Urticaria Acetaminophen 8.5610982225
MESH:D014581 Urticaria Astemizole 8.563097109 2147912 1976298 2565098 2859714 3080510 2885854 2568189 2883202 1683191 2568013 3134034
MESH:D014605 Uveitis Cyclosporine 3.831336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.4412125929
MESH:D018487 Ventricular Dysfunction, Left Doxorubicin 4.0717678736 16364871 17334414 17638931
MESH:D014717 Vertigo Astemizole 6.313105558
MESH:D014860 Warts Phenol 5.9519122958
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.1015886252
MESH:D014985 Xerophthalmia Cyclosporine 4.2917120751
No data
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA164725717
    • No data
    Releated disease ID Related disease Name
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    Releated drug ID Related drug Name
    PA451096prednisolone
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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