AutismKB 2.0

Annotation Detail for CTNND2


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Basic Information Top
Gene Symbol:CTNND2 ( GT24,NPRAP )
Gene Full Name: catenin (cadherin-associated protein), delta 2 (neural plakophilin-related arm-repeat protein)
Band: 5p15.2
Quick LinksEntrez ID:1501; OMIM: 604275; Uniprot ID:CTND2_HUMAN; ENSEMBL ID: ENSG00000169862; HGNC ID: 2516
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
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Pathway IDPathway Name
P00012Cadherin signaling pathway
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1831Prostate cancer
No data
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Desease Name
Mental retardation in cri-du-chat syndrome
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000643 Ammonium Chloride Ammonium Chloride affects the expression of CTNND2 mRNAaffects expression 16483693
D003520 Cyclophosphamide CTNND2 mRNA affects the susceptibility to [Paclitaxel co-treated with Fluorouracil co-treated with Doxorubicin co-treated with Cyclophosphamide]affects cotreatment|affects response to substance 16896004
D004317 Doxorubicin CTNND2 mRNA affects the susceptibility to [Paclitaxel co-treated with Fluorouracil co-treated with Doxorubicin co-treated with Cyclophosphamide]affects cotreatment|affects response to substance 16896004
D004958 Estradiol [Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of CTNND2 mRNAaffects cotreatment|increases expression 19619570
D004958 Estradiol Estradiol results in decreased expression of CTNND2 mRNAdecreases expression 19619570
D004958 Estradiol Estradiol results in increased expression of CTNND2 mRNAincreases expression 17555868
D005472 Fluorouracil CTNND2 mRNA affects the susceptibility to [Paclitaxel co-treated with Fluorouracil co-treated with Doxorubicin co-treated with Cyclophosphamide]affects cotreatment|affects response to substance 16896004
C071834 glycidamide glycidamide results in decreased expression of CTNND2 mRNAdecreases expression 17822822
D017239 Paclitaxel CTNND2 mRNA affects the susceptibility to [Paclitaxel co-treated with Fluorouracil co-treated with Doxorubicin co-treated with Cyclophosphamide]affects cotreatment|affects response to substance 16896004
D013749 Tetrachlorodibenzodioxin [Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of CTNND2 mRNAaffects cotreatment|increases expression 19619570
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of CTNND2 mRNAdecreases expression 19619570
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of CTNND2 mRNAincreases expression 17555868
D014415 Tunicamycin Tunicamycin results in decreased expression of CTNND2 mRNAdecreases expression 17127020
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.1311752688 14514962 15322242
MESH:D000138 Acidosis Ammonium Chloride 3.8418287403
MESH:D000230 Adenocarcinoma Doxorubicin 7.4317418594
MESH:D000230 Adenocarcinoma Estradiol 7.4311473722
MESH:D000230 Adenocarcinoma Fluorouracil 7.4317638652
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.6616835633
MESH:D000419 Albuminuria Doxorubicin 4.7821441931
MESH:D000740 Anemia Fluorouracil 9.3316511603 15504547 17963324
MESH:D000740 Anemia Tetrachlorodibenzodioxin 9.3311748828
MESH:D001161 Arteriosclerosis Cyclophosphamide 4.8615014928
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.2512125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.1115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8915746008
MESH:D019046 Bone Marrow Neoplasms Doxorubicin 5.0214601052
MESH:D001859 Bone Neoplasms Paclitaxel 4.7915867366
MESH:D001932 Brain Neoplasms Doxorubicin 4.0017150277
MESH:D001943 Breast Neoplasms Cyclophosphamide 3.0516978400 11325840 12006526 15136595 17020986 15093573 18234424 18323546 17388661
MESH:D001943 Breast Neoplasms Doxorubicin 3.0519526202 18628466 15668708 16264153 18234424 15136595 17426702 18695136 16595493 15994142 16826403 15939500 17369602 18382427 15634643 16096432 16935488 11325840 15993339 15692762 17983394 15567936 16115903 16322301
MESH:D001943 Breast Neoplasms Estradiol 3.0512948864 19861407 17289903 18497071 14630087 17018787 17261762 16675129
MESH:D001943 Breast Neoplasms Fluorouracil 3.0516557594 18608205 15136595 16110121 19217205 18357371 16595493
MESH:D001943 Breast Neoplasms Paclitaxel 3.0516115903 16273361 16244791 18323546 18234424 15136595 18223236 11325840
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 3.0520435547
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.7516111702
MESH:D002276 Carcinoid Tumor Doxorubicin 13.4416051944
MESH:D002276 Carcinoid Tumor Fluorouracil 13.4416051944
MESH:D002277 Carcinoma Fluorouracil 8.7417121937
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 8.7416835633
MESH:D006528 Carcinoma, Hepatocellular Cyclophosphamide 9.2119701751
MESH:D006528 Carcinoma, Hepatocellular Doxorubicin 9.2118059187 16234567 16023760 17876044
MESH:D006528 Carcinoma, Hepatocellular Estradiol 9.2116924424
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 9.2117045692 16332177 16799960 18930000 17971768 17088986
MESH:D006528 Carcinoma, Hepatocellular Paclitaxel 9.2116313753
MESH:D018827 Carcinoma, Lewis Lung Cyclophosphamide 5.1716152834
MESH:D002292 Carcinoma, Renal Cell Cyclophosphamide 11.4016201981
MESH:D002292 Carcinoma, Renal Cell Doxorubicin 11.401485588 16201981
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 11.4018695887
MESH:D002294 Carcinoma, Squamous Cell Doxorubicin 5.036189445
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 5.0316757204 17066447 16280240 18986760
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4716120746 18670907 18850075
MESH:D009202 Cardiomyopathies Doxorubicin 3.6616455267 18627295 17928571 17382496 15811867 17924179 16612575 17974986 16364871 17351982 16242529 17131338 16952015 17329180 15792986 15476868 17007740 17519947 16278810 16651473 17308081 16731534 16269455 16109756 15505089
MESH:D002311 Cardiomyopathy, Dilated Doxorubicin 3.0016243910 17334414
MESH:D002471 Cell Transformation, Neoplastic Estradiol 2.9118566989
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.3416835633
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1815668235 8697196 12621046 15340226 16354765
MESH:D003110 Colonic Neoplasms Fluorouracil 2.2615001691 16340194 17725105 18772588 16510598 17287894 17169374 17172411 17018589 17016597
MESH:D015179 Colorectal Neoplasms Doxorubicin 3.6418802399 18259882
MESH:D015179 Colorectal Neoplasms Fluorouracil 3.6417016601 17401013 16391804 15148649 18288408 20501625 18949393 17454858 17255274 17094418 17594712 18802399 15289873 18509181 16282729 16303861 18448328 16331619 14970324 16524972 17695437 18383874
MESH:D015179 Colorectal Neoplasms Paclitaxel 3.6418802399
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.2414669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2610048152 20055451 15322242
MESH:D003410 Cri-du-Chat Syndrome marker/mechanism
MESH:D003556 Cystitis Cyclophosphamide 5.3018710439 15276878 17010015 10498854 12161096 12388444 16651033 18433785 18295254 18372110 15643279 12913760 17979934 16614059 11948286 16413132 10700343 16989017 18483878 18093676
MESH:D007644 Darier Disease Fluorouracil 5.0816733453
MESH:D003921 Diabetes Mellitus, Experimental Cyclophosphamide 4.2415331540 11751995 10990075
MESH:D003922 Diabetes Mellitus, Type 1 Cyclophosphamide 3.2718772604
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7117107852
MESH:D003928 Diabetic Nephropathies Estradiol 3.5919279558
MESH:D056486 Drug-Induced Liver Injury Doxorubicin 4.0417416283
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 4.0420420201
MESH:D004362 Drug Toxicity Doxorubicin 8.6118602426
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 8.6111462148
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.5812711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.2216714409 18230668 15322242
MESH:D016889 Endometrial Neoplasms Doxorubicin 7.9717359293
MESH:D016889 Endometrial Neoplasms Estradiol 7.9719148513 18566989 11473722
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.2110568697 9294722
MESH:D004719 Endomyocardial Fibrosis Doxorubicin 5.4718037988
MESH:D004802 Eosinophilia Cyclophosphamide 4.4711006010
MESH:D004938 Esophageal Neoplasms Fluorouracil 4.9616337965 15173087 17638652 16481741 16785472
MESH:D004938 Esophageal Neoplasms Paclitaxel 4.9616481741
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.1611564622
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.7111858732
MESH:D018222 Fibromatosis, Aggressive Doxorubicin 4.8719069698
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 3.2120067830
MESH:D005909 Glioblastoma Doxorubicin 3.4717150277
MESH:D005910 Glioma Fluorouracil 2.9416145905
MESH:D018316 Gliosarcoma Cyclophosphamide 5.8011389073
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.9110696789
MESH:D006086 Graft vs Host Disease Cyclophosphamide 5.2916376943 11014644 15172196
MESH:D006258 Head and Neck Neoplasms Doxorubicin 8.3615692506
MESH:D006258 Head and Neck Neoplasms Fluorouracil 8.3615162350 18337622 15102660
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.4310048152 11294989
MESH:D006331 Heart Diseases Doxorubicin 3.6216144979 16244372 18674790 16495754 12587719 14766674 16244371 17875725 17888722 18006777 16330681 16879835 16707910
MESH:D006333 Heart Failure Doxorubicin 3.4617481944
MESH:D006394 Hemangiosarcoma Doxorubicin 4.1115692506
MESH:D006467 Hemophilia A Cyclophosphamide 5.5511918545
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.5411000095
MESH:D006504 Hepatic Veno-Occlusive Disease Cyclophosphamide 5.8514986274
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.1512621046 15340226 16120746
MESH:D006558 Herpes Genitalis Estradiol 5.3515709030
MESH:D006689 Hodgkin Disease Cyclophosphamide 8.3217606976 16135485
MESH:D006689 Hodgkin Disease Doxorubicin 8.3215147373 17606976 18501091
MESH:D019584 Hot Flashes Estradiol 4.0717088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.368697196 16959395 15340226 16354765 18606429
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9718850075 18670907
MESH:D007154 Immune System Diseases Cyclophosphamide 5.6516076520
MESH:D007248 Infertility, Male Cyclophosphamide 3.757193160 16517039
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 1.9512200463 12878042
MESH:D007333 Insulin Resistance Estradiol 3.0916393666 16627594
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.5416580747
MESH:D007674 Kidney Diseases Doxorubicin 6.5615369732 16775033 15699352
MESH:D007674 Kidney Diseases Estradiol 6.5615618244
MESH:D007676 Kidney Failure, Chronic Doxorubicin 4.3616707910
MESH:D007680 Kidney Neoplasms Estradiol 8.0615610895
MESH:D007680 Kidney Neoplasms Fluorouracil 8.0616985049
MESH:D007938 Leukemia Cyclophosphamide 3.5810602166
MESH:D004915 Leukemia, Erythroblastic, Acute Doxorubicin 5.4716085563
MESH:D015451 Leukemia, Lymphocytic, Chronic, B-Cell Cyclophosphamide 3.5717008537 17296974 17658394 17802794 18172266 18587576
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive Cyclophosphamide 4.2410373061
MESH:D007970 Leukopenia Cyclophosphamide 5.2510052129 11830472
MESH:D008080 Liposarcoma Paclitaxel 5.0417353645
MESH:D008106 Liver Cirrhosis, Experimental Doxorubicin 3.6016595196 16439617
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 3.6014659978 14716833
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.6012878042
MESH:D008113 Liver Neoplasms Fluorouracil 4.7115113037 17045692 18383874 16603448
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 4.7116984957
MESH:D008114 Liver Neoplasms, Experimental Doxorubicin 6.3117085340 16842330
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 6.3112151625
MESH:D008175 Lung Neoplasms Doxorubicin 3.566189445 17418594
MESH:D008175 Lung Neoplasms Fluorouracil 3.5615246190
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.5611884234 19555203
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 5.0815086387
MESH:D008223 Lymphoma Cyclophosphamide 8.3612854902
MESH:D008223 Lymphoma Doxorubicin 8.3616098063
MESH:D016393 Lymphoma, B-Cell Cyclophosphamide 4.8216675587
MESH:D008228 Lymphoma, Non-Hodgkin Cyclophosphamide 15.7111911406
MESH:D008228 Lymphoma, Non-Hodgkin Doxorubicin 15.7117654614
MESH:D008228 Lymphoma, Non-Hodgkin Paclitaxel 15.7114749477
MESH:D016399 Lymphoma, T-Cell Doxorubicin 4.8315621674
MESH:D008325 Mammary Neoplasms, Experimental Doxorubicin 6.5415458769
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 6.5417203775 11807958 11408345 16891317
MESH:D020149 Manganese Poisoning Estradiol 4.8019453300
MESH:D008545 Melanoma Doxorubicin 3.7716827129
MESH:D008545 Melanoma Paclitaxel 3.7716342250 12025231 12040289
MESH:D008546 Melanoma, Experimental Cyclophosphamide 5.0616388313
MESH:D008654 Mesothelioma Doxorubicin 3.1317638057
MESH:D028361 Mitochondrial Diseases Doxorubicin 4.7015792986
MESH:D009062 Mouth Neoplasms Fluorouracil 3.7916757204 18986760
MESH:D052016 Mucositis Doxorubicin 5.0817415656
MESH:D009101 Multiple Myeloma Paclitaxel 3.8314749477
MESH:D009203 Myocardial Infarction Doxorubicin 3.0215857846 19429709
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.1812213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 3.4416810080
MESH:D009362 Neoplasm Metastasis Doxorubicin 6.3718259882
MESH:D009362 Neoplasm Metastasis Paclitaxel 6.3715867366
MESH:D009369 Neoplasms Cyclophosphamide 5.7218854779
MESH:D009369 Neoplasms Fluorouracil 5.7218239605 18600527 16928823
MESH:D009389 Neovascularization, Pathologic Estradiol 4.0217289903
MESH:D009401 Nephrosis Doxorubicin 5.0316899518 16636307
MESH:D009404 Nephrotic Syndrome Doxorubicin 4.1816889571 15640375
MESH:D009421 Nervous System Malformations Estradiol 10.2711399458 16427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 10.2714600291
MESH:D009447 Neuroblastoma Cyclophosphamide 7.538761367 15176712 16115947
MESH:D009447 Neuroblastoma Doxorubicin 7.5315555623
MESH:D017599 Neuroectodermal Tumors Cyclophosphamide 5.1712837982 8761367
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.5716436463
MESH:D009503 Neutropenia Cyclophosphamide 4.548291058
MESH:D009845 Oligospermia Cyclophosphamide 5.0016517039
MESH:D010014 Osteolysis Paclitaxel 5.2615867366
MESH:D012516 Osteosarcoma Doxorubicin 4.2815930896
MESH:D010051 Ovarian Neoplasms Estradiol 5.2319401270
MESH:D010051 Ovarian Neoplasms Paclitaxel 5.2311161223
MESH:D010146 Pain Cyclophosphamide 3.7918093676 12161096
MESH:D010190 Pancreatic Neoplasms Cyclophosphamide 5.8211332152
MESH:D010190 Pancreatic Neoplasms Fluorouracil 5.8219003803 16929163 16500647 15113037
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.5712520081
MESH:D003557 Phyllodes Tumor Doxorubicin 5.4717983394
MESH:D010997 Pleural Neoplasms Doxorubicin 5.4717638057
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.8018163543
MESH:D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma Cyclophosphamide 3.9121297632
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.4811896295 11118676 11399792 11222880
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 4.0920887781
MESH:D011471 Prostatic Neoplasms Cyclophosphamide 1.8817136230
MESH:D011471 Prostatic Neoplasms Doxorubicin 1.8815897917 15749863 16729912 16888761 16868541 18437689
MESH:D011471 Prostatic Neoplasms Estradiol 1.8816740699
MESH:D011471 Prostatic Neoplasms Fluorouracil 1.8818626508 19082440
MESH:D011471 Prostatic Neoplasms Paclitaxel 1.8816729912 17136230 17172428 16356831
MESH:D011658 Pulmonary Fibrosis Cyclophosphamide 3.3516636934
MESH:D012004 Rectal Neoplasms Fluorouracil 4.1918286688 18722050 16160472 15538739
MESH:D051437 Renal Insufficiency Doxorubicin 4.4817922066
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.0818990726
MESH:D012509 Sarcoma Doxorubicin 4.1815625365 15675481 17710206 16767912 18313854 17203757
MESH:D012512 Sarcoma, Ewing's Doxorubicin 4.4814601052 16326096
MESH:D012514 Sarcoma, Kaposi Doxorubicin 5.0817846226
MESH:D012595 Scleroderma, Systemic Cyclophosphamide 5.0416636934
MESH:D012878 Skin Neoplasms Doxorubicin 5.9715692506
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.9716192470
MESH:D012983 Soft Tissue Neoplasms Doxorubicin 4.8316767912 15625365 17203757
OMIM:102530 SPERMATOGENIC FAILURE 6 Cyclophosphamide 5.8016517039
MESH:D013274 Stomach Neoplasms Fluorouracil 2.7918396642 17498489 16951190 17522103 19015929 16424979 17172411 15786421 18567086 19084572
MESH:D013274 Stomach Neoplasms Paclitaxel 2.7918396642 18506536
MESH:D015173 Supratentorial Neoplasms Cyclophosphamide 5.3412837982
MESH:D024801 Tauopathies Paclitaxel 5.1016930453
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.2212697716
MESH:D013964 Thyroid Neoplasms Doxorubicin 3.5216010429 17909728
MESH:D013978 Tibial Fractures Estradiol 5.0019048282
MESH:D014062 Tongue Neoplasms Fluorouracil 4.1816280240
MESH:D001749 Urinary Bladder Neoplasms Cyclophosphamide 5.7314692829
MESH:D001749 Urinary Bladder Neoplasms Doxorubicin 5.7317653716
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 4.0716803524
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.9112125929
MESH:D018487 Ventricular Dysfunction, Left Doxorubicin 4.4817334414 17678736 16364871 17638931
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.5715886252
No data
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA27017
    • No data
    Releated disease ID Related disease Name
    PA447216Schizophrenia
    No data
    Drug Bank Top

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    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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