AutismKB 2.0

Annotation Detail for PNPLA5


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Basic Information Top
Gene Symbol:PNPLA5 ( GS2L,dJ388M5,dJ388M5.4 )
Gene Full Name: patatin-like phospholipase domain containing 5
Band: 22q13.31
Quick LinksEntrez ID:150379; OMIM: 611589; Uniprot ID:PLPL5_HUMAN; ENSEMBL ID: ENSG00000100341; HGNC ID: 24888
Relate to Another Database: SFARIGene; denovo-db
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Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of PNPLA5 mRNAaffects expression 21346803
C059514 resveratrol resveratrol results in increased expression of PNPLA5 mRNAincreases expression 19371625
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D058186 Acute Kidney Injury resveratrol 4.4016538975
MESH:D000236 Adenoma resveratrol 3.5615688382
MESH:D000544 Alzheimer Disease resveratrol 2.6416162502 16183991
MESH:D001169 Arthritis, Experimental resveratrol 3.7717115116
MESH:D050197 Atherosclerosis resveratrol 3.5316873680 17967414
MESH:D002545 Brain Ischemia resveratrol 5.1717600658
MESH:D001943 Breast Neoplasms resveratrol 2.6517651959 16393696 17534123
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 3.3316705839
MESH:D006528 Carcinoma, Hepatocellular resveratrol 3.3316227395 19321006
MESH:D018827 Carcinoma, Lewis Lung resveratrol 5.4816675471
MESH:D002294 Carcinoma, Squamous Cell resveratrol 2.8116227395
MESH:D002318 Cardiovascular Diseases resveratrol 3.8015458977
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 3.096135515
MESH:D003092 Colitis resveratrol 4.8916474422
MESH:D003110 Colonic Neoplasms resveratrol 2.5116338953
MESH:D015179 Colorectal Neoplasms resveratrol 2.2316550006
MESH:D003327 Coronary Disease resveratrol 4.0416507316
MESH:D003490 Cyanosis 2,6-dinitrotoluene 4.7818551238
MESH:D003921 Diabetes Mellitus, Experimental resveratrol 4.2016873680
MESH:D003928 Diabetic Nephropathies resveratrol 4.4316286809
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 2.0718551238 21346803
MESH:D004487 Edema resveratrol 3.918985016
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental resveratrol 4.7017872969
MESH:D020345 Enterocolitis, Necrotizing resveratrol 5.6117923197
MESH:D006561 Herpes Simplex resveratrol 5.0616876885
MESH:D006937 Hypercholesterolemia resveratrol 4.5617188708
MESH:D006949 Hyperlipidemias resveratrol 4.6316873680
MESH:D017379 Hypertrophy, Left Ventricular resveratrol 4.8117488730
MESH:D020244 Infarction, Middle Cerebral Artery resveratrol 5.4117600658
MESH:D007249 Inflammation resveratrol 3.0516366677
MESH:D007251 Influenza, Human resveratrol 5.6116624496
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 3.4116705839
MESH:D015473 Leukemia, Promyelocytic, Acute resveratrol 3.8716087638
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 5.227678174
MESH:D008113 Liver Neoplasms resveratrol 5.2219812893 19073162 19321006 20405173
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 2.822876784 2876786 6135515
MESH:D016393 Lymphoma, B-Cell resveratrol 4.9117088997
MESH:D008228 Lymphoma, Non-Hodgkin resveratrol 4.3114749477
MESH:D015674 Mammary Neoplasms, Animal resveratrol 5.1315688416
MESH:D008325 Mammary Neoplasms, Experimental resveratrol 3.408985016 11606380
MESH:D008545 Melanoma resveratrol 2.4117992120
MESH:D008659 Metabolic Diseases resveratrol 4.9317112576
MESH:D009101 Multiple Myeloma resveratrol 3.8117164350 16490592 14749477 17049120 16267019 17935668
MESH:D009134 Muscular Atrophy, Spinal resveratrol 5.7617962980
MESH:D009203 Myocardial Infarction resveratrol 3.1917015251 16525036 16317513 17188708 16456233 17125593
MESH:D017202 Myocardial Ischemia resveratrol 4.4217015251 17125593
MESH:D009205 Myocarditis resveratrol 5.6517322642
MESH:D009336 Necrosis 2,6-dinitrotoluene 4.7518551238 7678174
MESH:D009374 Neoplasms, Experimental resveratrol 4.768985016
MESH:D019636 Neurodegenerative Diseases resveratrol 4.2417652729
MESH:D020078 Neurogenic Inflammation resveratrol 5.0117929310
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 3.9416049721
MESH:D015663 Osteoporosis, Postmenopausal resveratrol 4.8617513867
MESH:D011297 Prenatal Exposure Delayed Effects resveratrol 5.0616679765
MESH:D011471 Prostatic Neoplasms resveratrol 3.5615767336 17675339 16731767 17804756 17718901 17636462
MESH:D051436 Renal Insufficiency, Chronic resveratrol 6.6516325855
MESH:D015427 Reperfusion Injury resveratrol 3.4716314181 17058453 15827377 17520802 16317513
MESH:D012640 Seizures 2,6-dinitrotoluene 2.8518551238
MESH:D012878 Skin Neoplasms resveratrol 3.2215837718 8985016
OMIM:601367 STROKE, ISCHEMIC resveratrol 4.9916321402
MESH:D014062 Tongue Neoplasms resveratrol 4.7216227395
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 2.4316049721
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 5.2010091137
MESH:D002583 Uterine Cervical Neoplasms resveratrol 4.6117473185
MESH:D014594 Uterine Neoplasms resveratrol 4.8117044934
MESH:D018487 Ventricular Dysfunction, Left resveratrol 5.0617488730
No data
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AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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