AutismKB 2.0

Annotation Detail for CTRL


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Basic Information Top
Gene Symbol:CTRL ( CTRL1,MGC70821 )
Gene Full Name: chymotrypsin-like
Band: 16q22.1
Quick LinksEntrez ID:1506; OMIM: 118888; Uniprot ID:CTRL_HUMAN; ENSEMBL ID: ENSG00000141086; HGNC ID: 2524
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04972Pancreatic secretion
hsa04974Protein digestion and absorption
No data
No data
No data
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000643 Ammonium Chloride Ammonium Chloride affects the expression of CTRL mRNAaffects expression 16483693
D003024 Clozapine Clozapine results in increased expression of CTRL mRNAincreases expression 16715494
D006220 Haloperidol Haloperidol results in increased expression of CTRL mRNAincreases expression 16715494
C006253 pirinixic acid pirinixic acid results in increased expression of CTRL mRNAincreases expression 17426115
D013629 Tamoxifen Tamoxifen results in decreased expression of CTRL mRNAdecreases expression 15590111
D014501 Uranium Uranium affects the expression of CTRL mRNAaffects expression 15672453
C005460 uranyl acetate uranyl acetate affects the expression of CTRL mRNAaffects expression 15672453
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.9914745880
MESH:D000138 Acidosis Ammonium Chloride 3.9518287403
MESH:D055371 Acute Lung Injury pirinixic acid 3.4218653653
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.8816434500
MESH:D000380 Agranulocytosis Clozapine 5.4114617031 16160616 12649775
MESH:D001321 Autistic Disorder Haloperidol 2.7218080171 19368416
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.4319483382
MESH:D001943 Breast Neoplasms Tamoxifen 2.1816273361 16202921 20065188 18855134 19103187 20544844 18821012 19289846 18997820 18351453 16818667 18425577 17440819 20005174 19244106 18629630 16873071 19142967 19066611 19155303 17049068 15565566 19200415 18984771 19487384 11161223 20859285 19115204 19059307 15668708 17242785 20135344 21152245 19221464 19288272 18815881 19084267 19410462 21138602 17261762 19011961 19189212 20390343 17893378 19189210
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.8719066611
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 1.8516924424
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.8817572228
MESH:D002375 Catalepsy Haloperidol 5.311977408 15215559
MESH:D002779 Cholestasis pirinixic acid 3.0319176532
MESH:D003072 Cognition Disorders Clozapine 5.3217123785
MESH:D016757 Death, Sudden, Cardiac Haloperidol 5.1520210726
MESH:D003704 Dementia Haloperidol 4.8611575062
MESH:D003711 Demyelinating Diseases Tamoxifen 4.7219031437
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5318249437
MESH:D003924 Diabetes Mellitus, Type 2 Clozapine 3.0216402076
MESH:D003928 Diabetic Nephropathies Tamoxifen 3.7219279558
MESH:D006970 Disorders of Excessive Somnolence Clozapine 6.0015331141
MESH:D050171 Dyslipidemias Clozapine 4.3816402076
MESH:D004487 Edema pirinixic acid 2.7612083418
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 3.8719031437
MESH:D016889 Endometrial Neoplasms Tamoxifen 3.2119155303 17893378 20544844 16202921
MESH:D005234 Fatty Liver pirinixic acid 8.6319236843 20131406
MESH:D005234 Fatty Liver Tamoxifen 8.6314986274 19224547
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.3916709447
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.9214745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.5819069698
MESH:D006333 Heart Failure pirinixic acid 2.6920558911
MESH:D006529 Hepatomegaly pirinixic acid 3.3518467677 16221962 19176532 19772884
MESH:D006943 Hyperglycemia pirinixic acid 3.4520558911
MESH:D006948 Hyperkinesis Clozapine 5.3016046005
MESH:D007249 Inflammation Tamoxifen 2.4819457130
MESH:D007333 Insulin Resistance pirinixic acid 2.8016306350
MESH:D007680 Kidney Neoplasms Tamoxifen 3.2718625569
MESH:D008064 Lipidoses Clozapine 8.7317567588
MESH:D008064 Lipidoses Tamoxifen 8.7317567588 15342952
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 2.3915474484
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 2.3918564211
MESH:D008113 Liver Neoplasms pirinixic acid 4.7315890375 20007298 16377806
MESH:D008113 Liver Neoplasms Tamoxifen 4.7316684651
MESH:D008175 Lung Neoplasms Tamoxifen 1.7418625569
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 4.1519428831
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 2.7919196723 19196722 16827153 14580682 11731420
MESH:D020149 Manganese Poisoning Tamoxifen 4.9919453300
MESH:D008545 Melanoma Tamoxifen 1.9119393235 12393984
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.5815990972
MESH:D001523 Mental Disorders Clozapine 9.7116856516
MESH:D001523 Mental Disorders Haloperidol 9.7116856516
MESH:D024821 Metabolic Syndrome X Clozapine 4.6519142101
MESH:D009135 Muscular Diseases pirinixic acid 3.8616239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.2419151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.1616411023
MESH:D009362 Neoplasm Metastasis Tamoxifen 2.6419393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.5919410462
MESH:D009369 Neoplasms pirinixic acid 2.0617405874
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 4.4419200415 19196722 19189210
MESH:D009765 Obesity Clozapine 4.8918515891 19142110
MESH:D009765 Obesity pirinixic acid 4.8920558911
MESH:D011471 Prostatic Neoplasms Tamoxifen 3.1015067354
MESH:D011595 Psychomotor Agitation Haloperidol 5.3111575062
MESH:D011618 Psychotic Disorders Clozapine 9.8115331141
MESH:D011618 Psychotic Disorders Haloperidol 9.8111575062
MESH:D015427 Reperfusion Injury pirinixic acid 2.5019058328
MESH:D012559 Schizophrenia Clozapine 4.2117726453 18855531 19369910 16141801 17123785 20107430 20452607 20521320 20521326 20168265 20580759 17667964 11151749 11763009 18806925
MESH:D012559 Schizophrenia Haloperidol 4.2119369910 18513383 20107430 1830565
MESH:D013088 Spermatocele Tamoxifen 4.7416709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 4.4319457130
MESH:D017180 Tachycardia, Ventricular Haloperidol 5.0420210726
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 2.4416712894 8653321 17572228
MESH:D015430 Weight Gain Clozapine 4.7216402076 17502770 20521320 20107430 20564506 16141801
MESH:D015431 Weight Loss Clozapine 5.4717933447
Pathway ID Pathway Name
KEGG:04972 Pancreatic secretion
KEGG:04974 Protein digestion and absorption
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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