AutismKB 2.0

Annotation Detail for PROM2


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Basic Information Top
Gene Symbol:PROM2 ( MGC138714,PROML2 )
Gene Full Name: prominin 2
Band: 2q11.1
Quick LinksEntrez ID:150696; OMIM: NA; Uniprot ID:PROM2_HUMAN; ENSEMBL ID: ENSG00000155066; HGNC ID: 20685
Relate to Another Database: SFARIGene; denovo-db
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Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in increased expression of PROM2 mRNAincreases expression 18648102
D000643 Ammonium Chloride Ammonium Chloride affects the expression of PROM2 mRNAaffects expression 16483693
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of PROM2 mRNAincreases expression 17557909
D006830 Hydralazine [Hydralazine co-treated with Valproic Acid] results in increased expression of PROM2 mRNAaffects cotreatment|increases expression 17183730
D014635 Valproic Acid [Hydralazine co-treated with Valproic Acid] results in increased expression of PROM2 mRNAaffects cotreatment|increases expression 17183730
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 4.028875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 4.3019490988
MESH:D000138 Acidosis Ammonium Chloride 4.1018287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.5517505938
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.8814692618
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 2.933712494
MESH:D000550 Amblyopia Valproic Acid 5.8517688650
MESH:D001008 Anxiety Disorders Valproic Acid 3.8617497229
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.9511256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.8615885639
MESH:D001321 Autistic Disorder Valproic Acid 1.9818177632 17507914 16609825 17688650 18940202 17157402 19460635 18316065 20603192 18985861 19232924 18558336 18775368 15238991 18396377
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.631440618 11289319
MESH:D001714 Bipolar Disorder Valproic Acid 3.2320046352 17594078
MESH:D001848 Bone Diseases, Developmental Valproic Acid 3.618888407
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 1.777296757 3581430
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.817296757
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 2.997505956
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.8120734317
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 8.7419486331 9022650
MESH:D002779 Cholestasis Ethinyl Estradiol 8.7411677210 17681005 16919318 16105132 15861022 17110522 17333356
MESH:D019465 Craniofacial Abnormalities Valproic Acid 1.9016575769 17688650 8888407
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 3.282524372 8156756 11298694 12868966 18759878 11906362 8970840 14531868
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.893621924 2952479
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 4.218291058 18692083 6679447 9328219 18289764 11289319 6482804 1440618 18648102 16192314 7440962 9022650 9653073
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 4.2119641884 1733752
MESH:D004421 Dystonia Valproic Acid 4.451851702
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.6312538720
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 4.6417275665 3659116
MESH:D004828 Epilepsies, Partial Valproic Acid 4.533922381 16628512
MESH:D004827 Epilepsy Valproic Acid 3.0920417680 18234410
MESH:D004832 Epilepsy, Absence Valproic Acid 3.916426943 7562514 6254150
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 4.787750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 4.603659116
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 2.173581430
MESH:D005234 Fatty Liver Ethinyl Estradiol 9.0115345470
MESH:D005234 Fatty Liver Valproic Acid 9.0119224547 14986274
MESH:D005315 Fetal Diseases Valproic Acid 5.5016575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 4.5718558336 8888407
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.636705139
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.447505956
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.956705139
MESH:D006849 Hydrocephalus Valproic Acid 5.4117688650
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.4215034207
MESH:D046110 Hypertension, Pregnancy-Induced Hydralazine 5.1116612254
MESH:D007021 Hypospadias Ethinyl Estradiol 4.2916945680 16569931
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.8712013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.7117937319
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.638074119 9022650
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 3.276582329
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 2.1916294345 17596541
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.409327722 15034207
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 2.733712494 598648 1399818 6587162
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 4.8717228818
MESH:D008881 Migraine Disorders Valproic Acid 3.4418765137 18803445
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 4.408888407
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 3.3317596541
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 2.583581430
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 7.986679447
MESH:D009436 Neural Tube Defects Valproic Acid 7.9816359493 8888407
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 3.776482804 4026338
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.633988306
MESH:D016584 Panic Disorder Ethinyl Estradiol 4.0911578682
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.977296757
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 5.086228378
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 4.3720603192
MESH:D011537 Pruritus Ethinyl Estradiol 3.8516919318 15861022
MESH:D019310 Pseudolymphoma Valproic Acid 5.1512752131 11422049
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.643692021
MESH:D012208 Rhabdomyosarcoma Valproic Acid 4.5819155313
MESH:D012559 Schizophrenia Valproic Acid 2.1015737665 19110320
MESH:D012640 Seizures Valproic Acid 2.9614763951 11044598 16876388 1511512 11738929 3137016 17978042 15475178
MESH:D013088 Spermatocele Ethinyl Estradiol 4.5516709447
MESH:D016135 Spinal Dysraphism Valproic Acid 4.0619490988
MESH:D013226 Status Epilepticus Valproic Acid 5.1512833885
MESH:D019851 Thrombophilia Ethinyl Estradiol 4.0211994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.4815669648
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 3.156582329 6587162 7505956 3712494 1399818
MESH:D014178 Translocation, Genetic Valproic Acid 5.8517262798
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 5.063119515
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 2.398074119
MESH:D014564 Urogenital Abnormalities Valproic Acid 5.138888407
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.7414692618
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.9115869587 14671159
No data
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AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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