AutismKB 2.0

Annotation Detail for CTSD


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:CTSD ( CLN10,CPSD,MGC2311 )
Gene Full Name: cathepsin D
Band: 11p15.5
Quick LinksEntrez ID:1509; OMIM: 116840; Uniprot ID:CATD_HUMAN; ENSEMBL ID: ENSG00000117984; HGNC ID: 2529
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04142Lysosome
No data
Pathway IDPathway Name
200061LKB1 signaling events
200101Direct p53 effectors
200100Ceramide signaling pathway
No data
No data
Related Diseases/Disorders Top
Desease IDDesease Name
Lysosomal storage diseases
H00149Neuronal ceroid lipofuscinosis
Genetic disorders
Desease IDDesease Name
1740Alzheimer's disease
1763Keratosis
1934Cancer
2089Creutzfeldt-Jakob syndrome
2164Barrett's esophagus
Desease Name
periodontitis
Parkinson's disease
Alzheimer's disease
Creutzfeldt-Jakob Syndrome
IMMUNE
NEUROLOGICAL
No data
Desease Name
Ceroid lipofuscinosis, neuronal, 10
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C019499 2-nitrofluorene 2-nitrofluorene results in increased expression of CTSD mRNAincreases expression 15890375
C016392 3,3'-diindolylmethane 3,3'-diindolylmethane results in increased expression of CTSD mRNAincreases expression 16192472
C016583 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of CTSD mRNAincreases expression 15890375
D000082 Acetaminophen Acetaminophen affects the expression of CTSD mRNAaffects expression 17562736
D016604 Aflatoxin B1 Aflatoxin B1 results in increased expression of CTSD mRNAincreases expression 15890375
C011512 alpha-naphthoflavone alpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin inhibits the reaction [Estradiol results in increased expression of CTSD mRNA]]decreases reaction|increases expression 11165043
D000643 Ammonium Chloride Ammonium Chloride affects the expression of CTSD mRNAaffects expression 16483693
D000643 Ammonium Chloride Ammonium Chloride results in increased expression of CTSD proteinincreases expression 16483693
D003913 Dextroamphetamine Dextroamphetamine results in decreased expression of CTSD mRNAdecreases expression 12558987
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of CTSD mRNAdecreases expression 17879257
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of CTSD mRNAincreases expression 20382639
C006780 bisphenol A [bisphenol A results in increased activity of ESR1 protein] which results in increased expression of CTSD mRNAincreases activity|increases expression 14754635
D003042 Cocaine Cocaine affects the expression of CTSD mRNAaffects expression 15681117
D003300 Copper Copper affects the expression of CTSD proteinaffects expression 17192175
D003520 Cyclophosphamide [Cyclophosphamide co-treated with Mecamylamine] results in increased expression of CTSD mRNAaffects cotreatment|increases expression 18433785
D016572 Cyclosporine Cyclosporine results in increased expression of CTSD mRNAincreases expression 20106945
D003687 Dehydroepiandrosterone Dehydroepiandrosterone results in increased expression of CTSD mRNAincreases expression 18709148
17823450
D004041 Dietary Fats Dietary Fats results in decreased expression of CTSD mRNAdecreases expression 18042831
D004054 Diethylstilbestrol Diethylstilbestrol results in increased expression of CTSD mRNAincreases expression 15890375
D004128 Dimethylnitrosamine Dimethylnitrosamine results in increased expression of CTSD mRNAincreases expression 15890375
D004317 Doxorubicin CTSD protein results in decreased susceptibility to Doxorubicindecreases response to substance 18566016
D004317 Doxorubicin Doxorubicin results in increased expression of CTSD proteinincreases expression 18566016
D004642 Emodin Emodin results in decreased expression of CTSD mRNAdecreases expression 16045814
C044101 endotoxin, Escherichia coli endotoxin, Escherichia coli results in increased expression of CTSD mRNAincreases expression 15919760
D004958 Estradiol alpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin inhibits the reaction [Estradiol results in increased expression of CTSD mRNA]]decreases reaction|increases expression 11165043
D004958 Estradiol [Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of CTSD mRNAaffects cotreatment|decreases expression 19619570
D004958 Estradiol Estradiol promotes the reaction [ESR1 protein binds to CTSD promoter]affects binding|increases reaction 19698761
D004958 Estradiol Estradiol promotes the reaction [[ESR1 protein binds to CTSD promoter] which results in increased expression of CTSD mRNA]affects binding|increases expression|increases reaction 11165043
D004958 Estradiol Estradiol results in increased expression of CTSD mRNAincreases expression 19619570
11165043
15090535
15072547
16257430
20372779
15219790
11179685
14994273
D004958 Estradiol [Tetrachlorodibenzodioxin binds to and results in increased activity of [AHR protein binds to ARNT protein]] inhibits the reaction [Estradiol results in increased expression of CTSD mRNA]affects binding|decreases reaction|increases activity|increases expression 11165043
D004958 Estradiol Tetrachlorodibenzodioxin inhibits the reaction [Estradiol results in increased expression of CTSD mRNA]decreases reaction|increases expression 11165043
11179685
D004958 Estradiol Estradiol results in increased expression of CTSD mRNAincreases expression 17823450
18709148
16192472
D005419 Flavonoids Flavonoids results in increased expression of CTSD mRNAincreases expression 18035473
C070081 fulvestrant fulvestrant results in increased expression of CTSD mRNAincreases expression 15072547
C056933 fumonisin B1 fumonisin B1 results in increased expression of CTSD mRNAincreases expression 16221962
D019833 Genistein Genistein results in increased expression of CTSD mRNAincreases expression 15090535
D005944 Glucosamine Glucosamine affects the localization of CTSD proteinaffects localization 15972124
C475919 hydroxytamoxifen hydroxytamoxifen results in increased expression of CTSD mRNAincreases expression 15072547
C016517 indole-3-carbinol indole-3-carbinol results in decreased expression of CTSD proteindecreases expression 11110848
C016517 indole-3-carbinol indole-3-carbinol results in increased expression of CTSD mRNAincreases expression 16192472
D007545 Isoproterenol Isoproterenol results in decreased activity of CTSD proteindecreases activity 19172585
D007545 Isoproterenol mangiferin inhibits the reaction [Isoproterenol results in decreased activity of CTSD protein]decreases activity|decreases reaction 19172585
D008070 Lipopolysaccharides Lipopolysaccharides results in increased expression of CTSD mRNAincreases expression 15919760
C013592 mangiferin mangiferin inhibits the reaction [Isoproterenol results in decreased activity of CTSD protein]decreases activity|decreases reaction 19172585
D008464 Mecamylamine [Cyclophosphamide co-treated with Mecamylamine] results in increased expression of CTSD mRNAaffects cotreatment|increases expression 18433785
D008701 Methapyrilene Methapyrilene results in increased expression of CTSD mRNAincreases expression 15890375
D008748 Methylcholanthrene Methylcholanthrene results in increased expression of CTSD mRNAincreases expression 16257430
D008767 Methylmercury Compounds Methylmercury Compounds results in increased expression of CTSD mRNAincreases expression 16966085
D015741 Metribolone Metribolone results in decreased expression of CTSD proteindecreases expression 17152098
D005996 Nitroglycerin Nitroglycerin results in decreased expression of CTSD mRNAdecreases expression 12102619
C014707 nitrosobenzylmethylamine nitrosobenzylmethylamine results in increased expression of CTSD mRNAincreases expression 17616710
C025256 nonylphenol [nonylphenol results in increased activity of ESR1 protein] which results in increased expression of CTSD mRNAincreases activity|increases expression 14754635
D004963 Estrenes Estrenes analog results in increased expression of CTSD mRNAincreases expression 15219790
C041786 palm oil palm oil results in decreased expression of CTSD mRNAdecreases expression 18042831
D010269 Paraquat Paraquat results in decreased expression of CTSD mRNAdecreases expression 16797015
C031375 pepstatin pepstatin results in decreased activity of CTSD proteindecreases activity 17116725
C023036 perfluorooctanoic acid perfluorooctanoic acid results in increased expression of CTSD mRNAincreases expression 18709148
D010615 Phenacetin Phenacetin results in increased expression of CTSD mRNAincreases expression 17698508
C030299 phenylhydrazine phenylhydrazine results in increased expression of CTSD mRNAincreases expression 17698508
D010882 Piperonyl Butoxide Piperonyl Butoxide results in increased expression of CTSD mRNAincreases expression 15890375
C014153 pirimiphos methyl pirimiphos methyl results in decreased activity of CTSD proteindecreases activity 9204212
C014153 pirimiphos methyl pirimiphos methyl results in increased activity of CTSD proteinincreases activity 9204212
C006253 pirinixic acid pirinixic acid results in increased expression of CTSD mRNAincreases expression 18301758
C006253 pirinixic acid pirinixic acid results in increased expression of CTSD mRNAincreases expression 15890375
D011794 Quercetin Quercetin results in increased expression of CTSD mRNAincreases expression 15090535
C059514 resveratrol CTSD protein affects the reaction [resveratrol affects the localization of CYCS protein]affects localization|affects reaction 17116725
C059514 resveratrol CTSD protein affects the reaction [resveratrol promotes the reaction [BAX protein binds to BAX protein]]affects binding|affects reaction|increases reaction 17116725
C059514 resveratrol CTSD protein affects the reaction [resveratrol results in increased activity of CASP3 protein]affects reaction|increases activity 17116725
C059514 resveratrol CTSD protein affects the susceptibility to resveratrolaffects response to substance 17116725
C059514 resveratrol ESR1 protein affects the reaction [resveratrol affects the secretion of CTSD protein]affects reaction|affects secretion 16393696
C059514 resveratrol resveratrol affects the expression of CTSD mRNAaffects expression 16393696
C059514 resveratrol resveratrol results in increased expression of and results in increased metabolism of and affects the localization of CTSD proteinaffects localization|increases expression|increases metabolic processing 17116725
C059514 resveratrol [resveratrol results in increased expression of IGF2 protein] which results in increased secretion of CTSD proteinincreases expression|increases secretion 16393696
C059514 resveratrol resveratrol results in increased secretion of CTSD proteinincreases secretion 16393696
C059514 resveratrol resveratrol results in increased expression of CTSD mRNAincreases expression 16081268
C009166 retinol acetate retinol acetate results in increased expression of CTSD mRNAincreases expression 16772331
C410733 scriptaid scriptaid affects the expression of CTSD mRNAaffects expression 18813790
C009277 sodium arsenate sodium arsenate results in increased expression of CTSD mRNAincreases expression 16882884
D013749 Tetrachlorodibenzodioxin AHR protein promotes the reaction [Tetrachlorodibenzodioxin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CTSD mRNA]]decreases reaction|increases expression|increases reaction 11165043
D013749 Tetrachlorodibenzodioxin alpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin inhibits the reaction [Estradiol results in increased expression of CTSD mRNA]]decreases reaction|increases expression 11165043
D013749 Tetrachlorodibenzodioxin ARNT protein promotes the reaction [Tetrachlorodibenzodioxin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CTSD mRNA]]decreases reaction|increases expression|increases reaction 11165043
D013749 Tetrachlorodibenzodioxin [Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of CTSD mRNAaffects cotreatment|decreases expression 19619570
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin binds to and results in increased activity of [AHR protein binds to ARNT protein]] inhibits the reaction [Estradiol results in increased expression of CTSD mRNA]affects binding|decreases reaction|increases activity|increases expression 11165043
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin inhibits the reaction [Estradiol results in increased expression of CTSD mRNA]decreases reaction|increases expression 11179685
11165043
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin promotes the reaction [[AHR protein binds to ARNT protein] which binds to CTSD promoter]affects binding|increases reaction 11165043
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin promotes the reaction [[AHR protein binds to ARNT protein] which results in decreased expression of CTSD mRNA]affects binding|decreases expression|increases reaction 11165043
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of CTSD mRNAdecreases expression 19619570
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of CTSD mRNAincreases expression 11879969
D014108 Tosylphenylalanyl Chloromethyl Ketone Tosylphenylalanyl Chloromethyl Ketone results in increased expression of CTSD proteinincreases expression 10772776
D014212 Tretinoin Tretinoin results in increased expression of CTSD mRNAincreases expression 17218384
16054129
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.2511752688 15322242 14514962
MESH:D000138 Acidosis Ammonium Chloride 2.9518287403
MESH:D058186 Acute Kidney Injury resveratrol 3.3116538975
MESH:D055371 Acute Lung Injury Lipopolysaccharides 7.1818653653 11850527
MESH:D055371 Acute Lung Injury pirinixic acid 7.1818653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 11.4120127859 20464547
MESH:D000230 Adenocarcinoma Dimethylnitrosamine 11.4116033868
MESH:D000230 Adenocarcinoma Doxorubicin 11.4117418594
MESH:D000230 Adenocarcinoma Estradiol 11.4111473722
MESH:D000230 Adenocarcinoma Genistein 11.4111473722
MESH:D000236 Adenoma 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone 16.9916176798
MESH:D000236 Adenoma Benzo(a)pyrene 16.996695378
MESH:D000236 Adenoma Dimethylnitrosamine 16.9919555203
MESH:D000236 Adenoma Methylcholanthrene 16.996695378 10545420
MESH:D000236 Adenoma resveratrol 16.9915688382
MESH:D018248 Adenoma, Liver Cell pirinixic acid 7.8816434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 7.8816835633
MESH:D000309 Adrenal Insufficiency Dehydroepiandrosterone 5.1717302879
MESH:D000382 Agricultural Workers' Diseases Paraquat 3.1711874814
MESH:D000419 Albuminuria Doxorubicin 3.9621441931
MESH:D000437 Alcoholism Mecamylamine 5.1620201817
MESH:D000505 Alopecia Tretinoin 3.1215955085
MESH:D000544 Alzheimer Disease Copper 4.0816410023 16325427 17119284 16962711 16886094 16866297
MESH:D000544 Alzheimer Disease resveratrol 4.0816162502 16183991
MESH:D000686 Amyloidosis Diethylstilbestrol 3.9015469931
MESH:D000690 Amyotrophic Lateral Sclerosis Copper 3.8910694572
MESH:D000707 Anaphylaxis mangiferin 4.8814669257 16536907
MESH:D000740 Anemia Phenacetin 12.072444515
MESH:D000740 Anemia phenylhydrazine 12.072444515
MESH:D000740 Anemia Tetrachlorodibenzodioxin 12.0711748828
MESH:D000743 Anemia, Hemolytic Phenacetin 14.1817082564 17698508 1949026
MESH:D000743 Anemia, Hemolytic phenylhydrazine 14.1817698508 17084956 17082564
MESH:D000743 Anemia, Hemolytic Quercetin 14.1817084956
MESH:D018798 Anemia, Iron-Deficiency Copper 4.3416614410
MESH:D000799 Angioedema Acetaminophen 3.2210982225
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 3.4819183758
MESH:D001161 Arteriosclerosis Cyclophosphamide 8.3615014928
MESH:D001161 Arteriosclerosis Dietary Fats 8.3615238619
MESH:D001169 Arthritis, Experimental resveratrol 10.2217115116
MESH:D001169 Arthritis, Experimental Tosylphenylalanyl Chloromethyl Ketone 10.2218706406
MESH:D001169 Arthritis, Experimental Tretinoin 10.2216412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.1016292516
MESH:D001249 Asthma Tretinoin 2.1316456186
MESH:D001260 Ataxia Telangiectasia Quercetin 4.3715336622
MESH:D050197 Atherosclerosis mangiferin 8.9718450471
MESH:D050197 Atherosclerosis Methylcholanthrene 8.9711922910
MESH:D050197 Atherosclerosis resveratrol 8.9716873680 17967414
MESH:D001284 Atrophy fulvestrant 4.2711514358
MESH:D001321 Autistic Disorder Acetaminophen 1.5118445737
MESH:D001327 Autoimmune Diseases Quercetin 3.8119761891
MESH:D001471 Barrett Esophagus Tretinoin 3.8216935849
MESH:D001778 Blood Coagulation Disorders pirinixic acid 12.1119483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 12.1112125929
MESH:D001778 Blood Coagulation Disorders Tretinoin 12.1116206674 16197459
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.1715340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.3515746008
MESH:D019046 Bone Marrow Neoplasms Doxorubicin 4.0814601052
MESH:D001862 Bone Resorption bisphenol A 8.0611985600
MESH:D001862 Bone Resorption mangiferin 8.069881647
MESH:D001919 Bradycardia Isoproterenol 4.586740701
MESH:D002545 Brain Ischemia resveratrol 3.6817600658
MESH:D001932 Brain Neoplasms Copper 7.4317079463
MESH:D001932 Brain Neoplasms Doxorubicin 7.4317150277
MESH:D001943 Breast Neoplasms 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone 15.9020146248
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 15.9020146248 17474063
MESH:D001943 Breast Neoplasms bisphenol A 15.9017123778
MESH:D001943 Breast Neoplasms Copper 15.9015986119 17079463
MESH:D001943 Breast Neoplasms Cyclophosphamide 15.9018323546 17388661 15093573 11325840 12006526 18234424 15136595 16978400 17020986
MESH:D001943 Breast Neoplasms Dietary Fats 15.9020435547
MESH:D001943 Breast Neoplasms Diethylstilbestrol 15.9017129689 15324884
MESH:D001943 Breast Neoplasms Doxorubicin 15.9016264153 16595493 16096432 15993339 18628466 15668708 18695136 16826403 19526202 18234424 15136595 15994142 17983394 15939500 17369602 15567936 16115903 15634643 11325840 16935488 15692762 18382427 17426702 16322301
MESH:D001943 Breast Neoplasms Estradiol 15.9017289903 19861407 14630087 17261762 17018787 16675129 12948864 18497071
MESH:D001943 Breast Neoplasms fulvestrant 15.9018984771
MESH:D001943 Breast Neoplasms Genistein 15.9016873071 17200150 16541309
MESH:D001943 Breast Neoplasms indole-3-carbinol 15.9016082211
MESH:D001943 Breast Neoplasms Methylcholanthrene 15.9017474063
MESH:D001943 Breast Neoplasms Quercetin 15.9018628248
MESH:D001943 Breast Neoplasms resveratrol 15.9017534123 17651959 16393696
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 15.9020435547
MESH:D001943 Breast Neoplasms Tretinoin 15.9016166294 16443354 16873071
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 3.9816813970
MESH:D002105 Cadmium Poisoning Quercetin 4.9216962696
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 3.8516111702
MESH:D002276 Carcinoid Tumor Doxorubicin 4.1916051944
MESH:D002277 Carcinoma Dimethylnitrosamine 11.2219555203
MESH:D002277 Carcinoma Methylcholanthrene 11.2210545420
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 11.2216835633
MESH:D018236 Carcinoma, Embryonal Tretinoin 4.5416168501
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 19.923084413
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 19.9212907637 12619106 21507988
MESH:D006528 Carcinoma, Hepatocellular Cyclophosphamide 19.9219701751
MESH:D006528 Carcinoma, Hepatocellular Diethylstilbestrol 19.9215948411 16924424
MESH:D006528 Carcinoma, Hepatocellular Doxorubicin 19.9216023760 18059187 16234567 17876044
MESH:D006528 Carcinoma, Hepatocellular Estradiol 19.9216924424
MESH:D006528 Carcinoma, Hepatocellular Genistein 19.9216924424
MESH:D006528 Carcinoma, Hepatocellular Quercetin 19.9219519916 12508355
MESH:D006528 Carcinoma, Hepatocellular resveratrol 19.9216227395 19321006
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 19.921917145
MESH:D002278 Carcinoma in Situ bisphenol A 4.3817123778
MESH:D018827 Carcinoma, Lewis Lung Cyclophosphamide 9.4616152834
MESH:D018827 Carcinoma, Lewis Lung resveratrol 9.4616675471
MESH:D021441 Carcinoma, Pancreatic Ductal Quercetin 4.3617234771
MESH:D002292 Carcinoma, Renal Cell Cyclophosphamide 5.7916201981
MESH:D002292 Carcinoma, Renal Cell Doxorubicin 5.7916201981 1485588
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 11.9520419170
MESH:D002294 Carcinoma, Squamous Cell Dimethylnitrosamine 11.9516033868
MESH:D002294 Carcinoma, Squamous Cell Doxorubicin 11.956189445
MESH:D002294 Carcinoma, Squamous Cell resveratrol 11.9516227395
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 11.9516051514 16096774
MESH:D006332 Cardiomegaly Copper 13.3717327471
MESH:D006332 Cardiomegaly Isoproterenol 13.3711179087 7544033
MESH:D006332 Cardiomegaly Quercetin 13.3719794523
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 13.3716120746 18850075 18670907
MESH:D009202 Cardiomyopathies Doxorubicin 3.1115811867 17351982 17382496 17519947 15792986 17007740 16731534 16242529 16651473 16269455 16455267 17131338 17924179 15505089 17974986 16364871 16612575 16109756 16952015 15476868 16278810 17308081 17928571 18627295 17329180
MESH:D002311 Cardiomyopathy, Dilated Doxorubicin 2.7017334414 16243910
MESH:D002318 Cardiovascular Diseases Genistein 6.0516332659
MESH:D002318 Cardiovascular Diseases resveratrol 6.0515458977
MESH:D002386 Cataract Acetaminophen 5.9310977129
MESH:D002386 Cataract Tretinoin 5.9317460283
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 12.4420889678
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 12.4412371664
MESH:D002471 Cell Transformation, Neoplastic Estradiol 12.4418566989
MESH:D002471 Cell Transformation, Neoplastic Methylcholanthrene 12.4416192471
OMIM:610127 CEROID LIPOFUSCINOSIS, NEURONAL, 10 marker/mechanism
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 3.9816129372
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 2.6416835633
MESH:D002779 Cholestasis Cyclosporine 6.2119486331
MESH:D002779 Cholestasis pirinixic acid 6.2119176532
MESH:D002822 Choriocarcinoma Tretinoin 4.5416461808
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 4.7812621046 8697196 15340226 15668235 16354765
MESH:D002972 Cleft Palate Tretinoin 4.789407595
MESH:D019970 Cocaine-Related Disorders Cocaine 5.1119606084
MESH:D003092 Colitis resveratrol 7.6616474422
MESH:D003092 Colitis Tretinoin 7.6617035595
MESH:D003110 Colonic Neoplasms Genistein 5.0217182828
MESH:D003110 Colonic Neoplasms Quercetin 5.0217191121 19440933 15741050 11134977 16640504 17148506 19056647
MESH:D003110 Colonic Neoplasms resveratrol 5.0216338953
MESH:D015179 Colorectal Neoplasms Doxorubicin 3.1318259882 18802399
MESH:D015179 Colorectal Neoplasms Quercetin 3.1318852136 18095365
MESH:D015179 Colorectal Neoplasms resveratrol 3.1316550006
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.5417141729 14669216
MESH:D003327 Coronary Disease resveratrol 3.3416507316
MESH:D019465 Craniofacial Abnormalities sodium arsenate 3.3610525206
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 3.3615322242 20055451 10048152
MESH:D019465 Craniofacial Abnormalities Tretinoin 3.3616925845 14991402 10589399 9211117 17551590 9664655 8800419 9142499 9125849 9224671
MESH:D003456 Cryptorchidism Diethylstilbestrol 3.9816002989 12952375
MESH:D003457 Cryptosporidiosis mangiferin 5.2416547730
MESH:D003556 Cystitis Cyclophosphamide 4.3712913760 12161096 12388444 16651033 15643279 18710439 18483878 17010015 10700343 11948286 18372110 16614059 18433785 10498854 16413132 15276878 18295254 16989017 18093676 17979934
MESH:D003704 Dementia Methylmercury Compounds 4.4516140633
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.1118249437
MESH:D003921 Diabetes Mellitus, Experimental Cyclophosphamide 15.7810990075 15331540 11751995
MESH:D003921 Diabetes Mellitus, Experimental mangiferin 15.7812093613 19028559
MESH:D003921 Diabetes Mellitus, Experimental Quercetin 15.7819496084
MESH:D003921 Diabetes Mellitus, Experimental resveratrol 15.7816873680
MESH:D003922 Diabetes Mellitus, Type 1 Cyclophosphamide 5.3218772604
MESH:D003922 Diabetes Mellitus, Type 1 Dehydroepiandrosterone 5.3216616286
MESH:D003924 Diabetes Mellitus, Type 2 Genistein 6.1416647724
MESH:D003924 Diabetes Mellitus, Type 2 mangiferin 6.1411315760 9881663
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 6.1417107852
MESH:D003928 Diabetic Nephropathies Estradiol 12.2119279558
MESH:D003928 Diabetic Nephropathies mangiferin 12.2119960420 19706694
MESH:D003928 Diabetic Nephropathies resveratrol 12.2116286809
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 12.3019370779 17906064 11834606 11529661 12958197 14550746 16081117 19739265 14986274 11287661 12705907 12540782 17522070 10915739 14725611 12153990 18071297 19164858 11421492 19420014 11461765 11739529 16781746 12392966 19085960 11743745 19416960 12594235 10774834 16393943 16109766 15619225 16227642 18713872 15968718 2444490 16177239 19923254 17562736 16485898 10663392
MESH:D056486 Drug-Induced Liver Injury Dimethylnitrosamine 12.308172417
MESH:D056486 Drug-Induced Liver Injury Doxorubicin 12.3017416283
MESH:D056486 Drug-Induced Liver Injury fumonisin B1 12.3016221962
MESH:D056486 Drug-Induced Liver Injury sodium arsenate 12.3018186108
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 12.3020420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.4819426721
MESH:D004362 Drug Toxicity Doxorubicin 6.5618602426
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 6.5611462148
MESH:D050171 Dyslipidemias Dietary Fats 3.0018367378
MESH:D004487 Edema perfluorooctanoic acid 12.0417259670 12083418
MESH:D004487 Edema pirinixic acid 12.0412083418
MESH:D004487 Edema resveratrol 12.048985016
MESH:D004487 Edema Tetrachlorodibenzodioxin 12.0411000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 9.8816714409 18230668 15322242
MESH:D004489 Edema, Cardiac Tretinoin 9.8818230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental resveratrol 3.4517872969
MESH:D004714 Endometrial Hyperplasia Diethylstilbestrol 9.8716402032
MESH:D004714 Endometrial Hyperplasia Genistein 9.8716402032
MESH:D016889 Endometrial Neoplasms Diethylstilbestrol 18.9015700306 16804899
MESH:D016889 Endometrial Neoplasms Doxorubicin 18.9017359293
MESH:D016889 Endometrial Neoplasms Estradiol 18.9018566989 11473722 19148513
MESH:D016889 Endometrial Neoplasms Genistein 18.9011473722
MESH:D016889 Endometrial Neoplasms Tretinoin 18.9016569247
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.4910568697 9294722
MESH:D004719 Endomyocardial Fibrosis Doxorubicin 4.5318037988
MESH:D019446 Endotoxemia endotoxin, Escherichia coli 9.0318509659 17637181
MESH:D019446 Endotoxemia Lipopolysaccharides 9.0317637181 15328337 15821434
MESH:D020345 Enterocolitis, Necrotizing resveratrol 4.2517923197
MESH:D004802 Eosinophilia Cyclophosphamide 3.6311006010
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 8.7520426865
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 8.7516530937
MESH:D004938 Esophageal Neoplasms Dimethylnitrosamine 8.7517016578
MESH:D004938 Esophageal Neoplasms nitrosobenzylmethylamine 8.7516704527 15264214 15150132 15547733 15547721 15878914 16805852 16510608 15623463
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 7.2811564622
MESH:D005124 Eye Abnormalities Tretinoin 7.2816938888 9664655
MESH:D005234 Fatty Liver Cyclosporine 14.3619224547
MESH:D005234 Fatty Liver Dietary Fats 14.3619004024 17967931 18296743 19551842
MESH:D005234 Fatty Liver mangiferin 14.3615975614
MESH:D005234 Fatty Liver pirinixic acid 14.3620131406 19236843
MESH:D052776 Female Urogenital Diseases Diethylstilbestrol 3.2616534752 16611131 16002989 16513791 15751030
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 2.8611858732
MESH:D005334 Fever endotoxin, Escherichia coli 7.9916997862
MESH:D005334 Fever Lipopolysaccharides 7.999205823 11852909
MESH:D018222 Fibromatosis, Aggressive Doxorubicin 3.9819069698
MESH:D005354 Fibrosarcoma Methylcholanthrene 4.3314633661 10962813
MESH:D005355 Fibrosis Cyclosporine 26.8612639820 12168785
MESH:D005355 Fibrosis Dietary Fats 26.8618296743
MESH:D005355 Fibrosis Emodin 26.8619474275
MESH:D005355 Fibrosis Quercetin 26.8619474275
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 26.8620067830
MESH:D005355 Fibrosis Tretinoin 26.8617994277
MESH:D005756 Gastritis Acetaminophen 3.0616983495
MESH:D005833 Genital Neoplasms, Female Diethylstilbestrol 4.3416452187
MESH:D005885 Gingival Hyperplasia Cyclosporine 3.618708960
MESH:D005909 Glioblastoma Doxorubicin 13.5217150277
MESH:D005909 Glioblastoma Genistein 13.5216598420
MESH:D005909 Glioblastoma Quercetin 13.5219804834
MESH:D005909 Glioblastoma Tretinoin 13.5217312396
MESH:D005910 Glioma Quercetin 2.7817643826
MESH:D018316 Gliosarcoma Cyclophosphamide 4.9011389073
MESH:D005911 Gliosis Paraquat 4.5411124998
MESH:D018149 Glucose Intolerance sodium arsenate 4.5119446573
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 3.9710696789
MESH:D006086 Graft vs Host Disease Cyclophosphamide 4.4416376943 15172196 11014644
MESH:D006261 Headache Nitroglycerin 4.5711554966 11284996
MESH:D006258 Head and Neck Neoplasms Doxorubicin 6.4115692506
MESH:D006258 Head and Neck Neoplasms Tretinoin 6.4116096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 4.5416084493
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 9.0220471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 9.0211294989 10048152
MESH:D006330 Heart Defects, Congenital Tretinoin 9.0214991402 9664655
MESH:D006331 Heart Diseases Doxorubicin 6.6916330681 14766674 18674790 17888722 16707910 12587719 17875725 16495754 16244372 16144979 16879835 16244371 18006777
MESH:D006331 Heart Diseases mangiferin 6.6912093613
MESH:D006333 Heart Failure Doxorubicin 9.6317481944
MESH:D006333 Heart Failure Isoproterenol 9.6318097624
MESH:D006333 Heart Failure pirinixic acid 9.6320558911
MESH:D006394 Hemangiosarcoma Doxorubicin 3.3615692506
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 3.8115720958
MESH:D006463 Hemolytic-Uremic Syndrome Lipopolysaccharides 3.8516366002
MESH:D006467 Hemophilia A Cyclophosphamide 4.6911918545
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 2.7911000095
MESH:D006504 Hepatic Veno-Occlusive Disease Cyclophosphamide 4.9114986274
MESH:D006521 Hepatitis, Chronic Copper 4.6617338147
MESH:D006527 Hepatolenticular Degeneration Copper 4.5717276780 16607473 17109627 19888908 17182432
MESH:D006529 Hepatomegaly fumonisin B1 15.8916221962
MESH:D006529 Hepatomegaly perfluorooctanoic acid 15.893609246
MESH:D006529 Hepatomegaly pirinixic acid 15.8916221962 18467677 19772884 19176532
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 15.8916120746 12621046 15340226
MESH:D006558 Herpes Genitalis Estradiol 4.4115709030
MESH:D006561 Herpes Simplex mangiferin 8.2510715843
MESH:D006561 Herpes Simplex resveratrol 8.2516876885
MESH:D006689 Hodgkin Disease Cyclophosphamide 6.0217606976 16135485
MESH:D006689 Hodgkin Disease Doxorubicin 6.0215147373 18501091 17606976
MESH:D019584 Hot Flashes Estradiol 3.1417088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.4216959395 16354765 8697196 15340226 18606429
MESH:D006930 Hyperalgesia Acetaminophen 10.2616870215
MESH:D006930 Hyperalgesia perfluorooctanoic acid 10.2612083418
MESH:D006930 Hyperalgesia Tretinoin 10.2616870215
MESH:D006937 Hypercholesterolemia Dietary Fats 7.4021332399
MESH:D006937 Hypercholesterolemia resveratrol 7.4017188708
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 3.9716778211
MESH:D006943 Hyperglycemia pirinixic acid 7.4720558911
MESH:D006943 Hyperglycemia Quercetin 7.4711834736 18262572
MESH:D006946 Hyperinsulinism mangiferin 4.4911315760 9881663
MESH:D006949 Hyperlipidemias Dietary Fats 12.3621332399
MESH:D006949 Hyperlipidemias mangiferin 12.3615975614
MESH:D006949 Hyperlipidemias resveratrol 12.3616873680
MESH:D006965 Hyperplasia Diethylstilbestrol 3.8414722030 12960047
MESH:D006967 Hypersensitivity mangiferin 4.1716536907
MESH:D006973 Hypertension Cyclosporine 6.9810903974
MESH:D006973 Hypertension Quercetin 6.9818356687
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 6.9818850075 18670907
MESH:D006984 Hypertrophy Isoproterenol 4.6412791704
MESH:D017379 Hypertrophy, Left Ventricular resveratrol 3.7717488730
MESH:D007021 Hypospadias Diethylstilbestrol 3.9916002989
MESH:D007022 Hypotension Isoproterenol 4.246740701
MESH:D007154 Immune System Diseases Cyclophosphamide 11.3816076520
MESH:D007154 Immune System Diseases mangiferin 11.3816076520
MESH:D020244 Infarction, Middle Cerebral Artery resveratrol 4.0517600658
MESH:D007246 Infertility Diethylstilbestrol 3.7815036965
MESH:D007248 Infertility, Male Cyclophosphamide 12.747193160 16517039
MESH:D007248 Infertility, Male fulvestrant 12.7411514358
MESH:D007248 Infertility, Male Paraquat 12.744850670
MESH:D007248 Infertility, Male pirimiphos methyl 12.7417604518
MESH:D007249 Inflammation Dietary Fats 18.8420412841
MESH:D007249 Inflammation Flavonoids 18.8417296493
MESH:D007249 Inflammation Lipopolysaccharides 18.8417237260 17963957 9205823 17255318 12878042
MESH:D007249 Inflammation mangiferin 18.8415222974
MESH:D007249 Inflammation perfluorooctanoic acid 18.8412083418
MESH:D007249 Inflammation resveratrol 18.8416366677
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 18.8412200463 12878042
MESH:D007251 Influenza, Human Quercetin 9.1316624496
MESH:D007251 Influenza, Human resveratrol 9.1316624496
MESH:D007333 Insulin Resistance bisphenol A 18.7516393666
MESH:D007333 Insulin Resistance Dietary Fats 18.7518457598 11836018
MESH:D007333 Insulin Resistance Estradiol 18.7516393666 16627594
MESH:D007333 Insulin Resistance mangiferin 18.7511315760
MESH:D007333 Insulin Resistance pirinixic acid 18.7516306350
MESH:D007410 Intestinal Diseases Tretinoin 3.1817994277
MESH:D019189 Iron Metabolism Disorders Lipopolysaccharides 4.0717255318
MESH:D007511 Ischemia mangiferin 4.6816806951
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 8.1116580747
MESH:D007569 Jaw Abnormalities Tretinoin 8.1115992940 17551590
MESH:D007627 Keloid Quercetin 4.3617086741
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 3.8215604871
MESH:D007674 Kidney Diseases Acetaminophen 18.9312587719 15629191
MESH:D007674 Kidney Diseases Cyclosporine 18.938314463 10903974 18776723
MESH:D007674 Kidney Diseases Doxorubicin 18.9315699352 16775033 15369732
MESH:D007674 Kidney Diseases Estradiol 18.9315618244
MESH:D007674 Kidney Diseases mangiferin 18.9312093613
MESH:D007674 Kidney Diseases Quercetin 18.9316962696
MESH:D007676 Kidney Failure, Chronic Copper 8.5416518626
MESH:D007676 Kidney Failure, Chronic Doxorubicin 8.5416707910
MESH:D007680 Kidney Neoplasms Cyclosporine 9.5412371664
MESH:D007680 Kidney Neoplasms Diethylstilbestrol 9.5415003126 14681315 16762066
MESH:D007680 Kidney Neoplasms Estradiol 9.5415610895
MESH:D007859 Learning Disorders Copper 12.9217134702
MESH:D007859 Learning Disorders Diethylstilbestrol 12.9217184923
MESH:D007859 Learning Disorders mangiferin 12.9219182383
MESH:D007938 Leukemia Cyclophosphamide 12.2010602166
MESH:D007938 Leukemia Genistein 12.2018980019 17468513
MESH:D007938 Leukemia Quercetin 12.2017468513
MESH:D007938 Leukemia Tretinoin 12.2017143497
MESH:D004915 Leukemia, Erythroblastic, Acute Doxorubicin 4.5316085563
MESH:D015451 Leukemia, Lymphocytic, Chronic, B-Cell Cyclophosphamide 3.2017658394 17802794 18587576 18172266 17008537 17296974
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell Emodin 4.4817077332
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive Cyclophosphamide 7.5110373061
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive mangiferin 7.5115498116
MESH:D007951 Leukemia, Myeloid Tretinoin 3.1516482212 16932348 19285840
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 1.9616294345 19850784 17596541
MESH:D015473 Leukemia, Promyelocytic, Acute resveratrol 6.3616087638
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 6.3616140955 12679006 17294898 16788101 17107899 19075265 17649720 17506722 19642359 16935935 9834237 15748426 17712046 16331271 16823087 17301526 17361223 19029980 17217047 16766008 19035177 19225113 16891316 17368321 17339181
MESH:D007970 Leukopenia Cyclophosphamide 9.7510052129 11830472
MESH:D007970 Leukopenia Lipopolysaccharides 9.7515821434
MESH:D007984 Leydig Cell Tumor perfluorooctanoic acid 4.628812269
MESH:D017880 Limb Deformities, Congenital Tretinoin 2.869224671
MESH:D008103 Liver Cirrhosis Dietary Fats 2.5218296743
MESH:D008106 Liver Cirrhosis, Experimental Dimethylnitrosamine 15.8316627068 18371158 16009107 15366600 15591649 18237412 16169303 18364076 15161499 18672772 17198567 15081153 18637143 16270385 16544323 15339415 15793283 17348192 17203207 17640959 18567088 14709902 15723089 15492853 17724770 17666798 16603200 14659978 17881167 15086199 17534399 15942678 18629640 17432682 15138612 15763062 18210741 17036385 12925901 15864749 15744066 16042886 15577212 15733078 15798949 12918455 18239293 18095165 15298665 15842777 17196135 15067225 15504291 14568256 16570917 14643895 17465448 15369754 17719030 15479170 15099470 17201889 14726149 15571005 15383259
MESH:D008106 Liver Cirrhosis, Experimental Doxorubicin 15.8316595196 16439617
MESH:D008106 Liver Cirrhosis, Experimental Emodin 15.8315288473
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 15.8314659978 14716833
MESH:D008106 Liver Cirrhosis, Experimental Genistein 15.8317823541
MESH:D008106 Liver Cirrhosis, Experimental Lipopolysaccharides 15.8312878042
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 15.8315474484
MESH:D008106 Liver Cirrhosis, Experimental Quercetin 15.8312741479
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 15.8312878042
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 15.8316248980 18397230
MESH:D008107 Liver Diseases Acetaminophen 1.4719460945 11587558 19014921 16611625 12969438 12587719 19784758 16610002
MESH:D017114 Liver Failure, Acute Acetaminophen 7.9017185352 16871587
MESH:D017114 Liver Failure, Acute Dimethylnitrosamine 7.9017457977
MESH:D008113 Liver Neoplasms 2-nitrofluorene 48.3515890375
MESH:D008113 Liver Neoplasms 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone 48.3515890375
MESH:D008113 Liver Neoplasms Aflatoxin B1 48.352125692 15890375 18177683 9163691
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 48.3521137059 20195826
MESH:D008113 Liver Neoplasms Copper 48.3520302851
MESH:D008113 Liver Neoplasms Dehydroepiandrosterone 48.3518709148
MESH:D008113 Liver Neoplasms Diethylstilbestrol 48.3516712894 15890375
MESH:D008113 Liver Neoplasms Dimethylnitrosamine 48.3515890375 3113478
MESH:D008113 Liver Neoplasms Methapyrilene 48.3515890375
MESH:D008113 Liver Neoplasms perfluorooctanoic acid 48.3518709148 14757943
MESH:D008113 Liver Neoplasms Piperonyl Butoxide 48.3518648771 19690152 15890375 20101389
MESH:D008113 Liver Neoplasms pirinixic acid 48.3516377806 20007298 15890375
MESH:D008113 Liver Neoplasms Quercetin 48.3518980244
MESH:D008113 Liver Neoplasms resveratrol 48.3519321006 19073162 20405173 19812893
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 48.3516984957
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 22.078603461
MESH:D008114 Liver Neoplasms, Experimental Dehydroepiandrosterone 22.078603461
MESH:D008114 Liver Neoplasms, Experimental Dimethylnitrosamine 22.071848544 15603536 6150874
MESH:D008114 Liver Neoplasms, Experimental Doxorubicin 22.0716842330 17085340
MESH:D008114 Liver Neoplasms, Experimental Methylcholanthrene 22.071399818 598648
MESH:D008114 Liver Neoplasms, Experimental Quercetin 22.0719519916
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 22.0712151625
MESH:D055370 Lung Injury Lipopolysaccharides 3.4221114838
MESH:D008175 Lung Neoplasms 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone 13.2518508827 19931552 15172992 9255578 15893417 18813816 12438228 14755239 16401635 16061637 17139156
MESH:D008175 Lung Neoplasms Aflatoxin B1 13.2514755239
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 13.2518816296 20869020 18569708 18520028 20464547 6695378 20135361 20064080 17053015
MESH:D008175 Lung Neoplasms Dimethylnitrosamine 13.2516061637 11884234 19555203
MESH:D008175 Lung Neoplasms Doxorubicin 13.256189445 17418594
MESH:D008175 Lung Neoplasms mangiferin 13.2518520028 18569708 18816296
MESH:D008175 Lung Neoplasms Methylcholanthrene 13.2510545420 1399818 20512841 9230183 21163286 20970405 6695378 16271038 17909032 7750092 11893704 15390079 16337739
MESH:D008175 Lung Neoplasms Quercetin 13.2516280456
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 13.2519555203 11884234
MESH:D008181 Lupus Nephritis Diethylstilbestrol 4.5415166399
MESH:D008223 Lymphoma Cyclophosphamide 10.0812854902
MESH:D008223 Lymphoma Diethylstilbestrol 10.0815700306
MESH:D008223 Lymphoma Doxorubicin 10.0816098063
MESH:D016393 Lymphoma, B-Cell Cyclophosphamide 8.6016675587
MESH:D016393 Lymphoma, B-Cell resveratrol 8.6017088997
MESH:D008228 Lymphoma, Non-Hodgkin Cyclophosphamide 11.7311911406
MESH:D008228 Lymphoma, Non-Hodgkin Doxorubicin 11.7317654614
MESH:D008228 Lymphoma, Non-Hodgkin resveratrol 11.7314749477
MESH:D016399 Lymphoma, T-Cell Doxorubicin 3.9715621674
MESH:D052801 Male Urogenital Diseases Diethylstilbestrol 4.8916002989
MESH:D015674 Mammary Neoplasms, Animal resveratrol 3.6415688416
MESH:D008325 Mammary Neoplasms, Experimental Dehydroepiandrosterone 14.4616457693
MESH:D008325 Mammary Neoplasms, Experimental Doxorubicin 14.4615458769
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 14.4611807958 17203775 11408345 16891317
MESH:D008325 Mammary Neoplasms, Experimental Genistein 14.4614578162 12929590
MESH:D008325 Mammary Neoplasms, Experimental resveratrol 14.4611606380 8985016
MESH:D020149 Manganese Poisoning Estradiol 3.8619453300
MESH:D008527 Medulloblastoma Tretinoin 2.5117453147
MESH:D008545 Melanoma Doxorubicin 4.3616827129
MESH:D008545 Melanoma resveratrol 4.3617992120
MESH:D008545 Melanoma Tretinoin 4.3616752155
MESH:D008546 Melanoma, Experimental Acetaminophen 8.8619513568
MESH:D008546 Melanoma, Experimental Cyclophosphamide 8.8616388313
MESH:D008569 Memory Disorders mangiferin 8.3919182383
MESH:D008569 Memory Disorders Methylmercury Compounds 8.3918436314
MESH:D008591 Meningomyelocele Tretinoin 3.8316940565
MESH:D007706 Menkes Kinky Hair Syndrome Copper 5.2717109627 17268249
MESH:D008654 Mesothelioma Doxorubicin 2.7817638057
MESH:D008659 Metabolic Diseases resveratrol 3.8317112576
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.1716801185
MESH:D008708 Methemoglobinemia Nitroglycerin 8.053537620
MESH:D008708 Methemoglobinemia Phenacetin 8.0516296465 1949026 4834387 3537620
MESH:D020326 Migraine without Aura Nitroglycerin 4.5514659530
MESH:D028361 Mitochondrial Diseases Doxorubicin 3.9515792986
MESH:D009041 Motion Sickness Dextroamphetamine 4.901613127
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 2.7116381670
MESH:D009069 Movement Disorders Methylmercury Compounds 4.7618436314
MESH:D052016 Mucositis Doxorubicin 4.1817415656
MESH:D009101 Multiple Myeloma resveratrol 3.0316267019 17935668 16490592 17164350 17049120 14749477
MESH:D009134 Muscular Atrophy, Spinal resveratrol 4.2617962980
MESH:D009135 Muscular Diseases pirinixic acid 2.9116239165
MESH:D009139 Musculoskeletal Abnormalities sodium arsenate 4.3118186108
MESH:D009190 Myelodysplastic Syndromes Tretinoin 2.7017596541
MESH:D009203 Myocardial Infarction Cocaine 31.1318072171
MESH:D009203 Myocardial Infarction Doxorubicin 31.1315857846 19429709
MESH:D009203 Myocardial Infarction Genistein 31.1317141266
MESH:D009203 Myocardial Infarction Isoproterenol 31.1315740881 17052832 19172585 16538859 16697266 16584858 19595682
MESH:D009203 Myocardial Infarction mangiferin 31.1316584858 16538859 16697266 17052832 19172585
MESH:D009203 Myocardial Infarction Nitroglycerin 31.1314729435
MESH:D009203 Myocardial Infarction pirinixic acid 31.1319151258
MESH:D009203 Myocardial Infarction Quercetin 31.1319595682
MESH:D009203 Myocardial Infarction resveratrol 31.1316317513 17188708 17125593 16456233 17015251 16525036
MESH:D017202 Myocardial Ischemia resveratrol 7.3817125593 17015251
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 7.3812213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 16.3816810080
MESH:D015428 Myocardial Reperfusion Injury Genistein 16.3817141266
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 16.3816411023
MESH:D015428 Myocardial Reperfusion Injury Quercetin 16.3819207477
MESH:D009205 Myocarditis resveratrol 4.1517322642
MESH:D009362 Neoplasm Metastasis Doxorubicin 2.6818259882
MESH:D009369 Neoplasms Benzo(a)pyrene 15.4011141357
MESH:D009369 Neoplasms Cyclophosphamide 15.4018854779
MESH:D009369 Neoplasms Diethylstilbestrol 15.4015313581
MESH:D009369 Neoplasms pirinixic acid 15.4017405874
MESH:D009369 Neoplasms Quercetin 15.4015185748
MESH:D009369 Neoplasms Tretinoin 15.4016946489 16594593
MESH:D009374 Neoplasms, Experimental resveratrol 3.418985016
MESH:D009389 Neovascularization, Pathologic Copper 8.3317308104
MESH:D009389 Neovascularization, Pathologic Estradiol 8.3317289903
MESH:D009401 Nephrosis Doxorubicin 4.1716899518 16636307
MESH:D009402 Nephrosis, Lipoid Cyclosporine 3.8217954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 7.5719348381 18481113
MESH:D009404 Nephrotic Syndrome Doxorubicin 7.5715640375 16889571
MESH:D009410 Nerve Degeneration mangiferin 7.3217433543
MESH:D009410 Nerve Degeneration Paraquat 7.3216893418
MESH:D009421 Nervous System Malformations bisphenol A 30.8016427766 11399458
MESH:D009421 Nervous System Malformations Diethylstilbestrol 30.8011399458
MESH:D009421 Nervous System Malformations Estradiol 30.8016427766 11399458
MESH:D009421 Nervous System Malformations Genistein 30.8016427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 30.8014600291
MESH:D009421 Nervous System Malformations Tretinoin 30.809125849
MESH:D009436 Neural Tube Defects sodium arsenate 6.2119446573 10525206 18186108 11749123
MESH:D009436 Neural Tube Defects Tretinoin 6.219142499
MESH:D009447 Neuroblastoma Cyclophosphamide 6.058761367 15176712 16115947
MESH:D009447 Neuroblastoma Doxorubicin 6.0515555623
MESH:D019636 Neurodegenerative Diseases Acetaminophen 6.6818514411
MESH:D019636 Neurodegenerative Diseases resveratrol 6.6817652729
MESH:D017599 Neuroectodermal Tumors Cyclophosphamide 4.2812837982 8761367
MESH:D020078 Neurogenic Inflammation Quercetin 8.8217929310
MESH:D020078 Neurogenic Inflammation resveratrol 8.8217929310
MESH:D009503 Neutropenia Cyclophosphamide 3.778291058
MESH:D052556 Niemann-Pick Disease, Type C perfluorooctanoic acid 4.369802331
MESH:D009765 Obesity Dietary Fats 3.7920518802 21332399 11836018 17217161 19632207 18674790 16723640 20132043 18457598
MESH:D009765 Obesity pirinixic acid 3.7920558911
MESH:D009845 Oligospermia Cyclophosphamide 4.1116517039
MESH:D010024 Osteoporosis Genistein 2.8619401787
MESH:D015663 Osteoporosis, Postmenopausal Dehydroepiandrosterone 19.4616397352
MESH:D015663 Osteoporosis, Postmenopausal Genistein 19.4616169203
MESH:D015663 Osteoporosis, Postmenopausal Quercetin 19.4619495926
MESH:D015663 Osteoporosis, Postmenopausal resveratrol 19.4617513867
MESH:D012516 Osteosarcoma Doxorubicin 3.6215930896
MESH:D010049 Ovarian Diseases bisphenol A 4.3811985600
MESH:D010051 Ovarian Neoplasms Estradiol 9.3519401270
MESH:D010051 Ovarian Neoplasms Genistein 9.3519005980
MESH:D010051 Ovarian Neoplasms Quercetin 9.3519005980
MESH:D010051 Ovarian Neoplasms Tretinoin 9.3516936753
MESH:D010146 Pain Acetaminophen 8.4316870215
MESH:D010146 Pain Cyclophosphamide 8.4318093676 12161096
MESH:D010146 Pain Tretinoin 8.4316870215
MESH:D010190 Pancreatic Neoplasms 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone 10.2512384795
MESH:D010190 Pancreatic Neoplasms Cyclophosphamide 10.2511332152
MESH:D010190 Pancreatic Neoplasms Quercetin 10.2516965848
MESH:D010190 Pancreatic Neoplasms Tretinoin 10.2515976015
MESH:D010300 Parkinson Disease mangiferin 4.9617433543
MESH:D010300 Parkinson Disease Paraquat 4.9611181820 11445065 16140633 12911755 11124998 15451049 16510128 15824117
MESH:D010302 Parkinson Disease, Secondary Paraquat 3.8416190885
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 3.6312520081
MESH:D010518 Periodontitis mangiferin 4.9819026997
MESH:D003557 Phyllodes Tumor Doxorubicin 4.5317983394
MESH:D010900 Pituitary Diseases Diethylstilbestrol 4.5514722030
MESH:D010911 Pituitary Neoplasms Diethylstilbestrol 4.0816977796 15687265
MESH:D010997 Pleural Neoplasms Doxorubicin 4.5317638057
MESH:D011014 Pneumonia Lipopolysaccharides 9.1012224865 11605937
MESH:D011014 Pneumonia Paraquat 9.1012504350
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 2.9818163543
MESH:D011230 Precancerous Conditions Cyclosporine 7.3812371664
MESH:D011230 Precancerous Conditions Quercetin 7.3819056647
MESH:D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma Cyclophosphamide 3.4321297632
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 30.0510548101
MESH:D011297 Prenatal Exposure Delayed Effects Diethylstilbestrol 30.0517184923
MESH:D011297 Prenatal Exposure Delayed Effects Methylmercury Compounds 30.0518436314
MESH:D011297 Prenatal Exposure Delayed Effects perfluorooctanoic acid 30.0517132714
MESH:D011297 Prenatal Exposure Delayed Effects resveratrol 30.0516679765
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 30.0511896295 11399792 11118676 11222880
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 8.7320887781
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 8.7320887781
MESH:D011471 Prostatic Neoplasms marker/mechanism 17013881
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 3.1517292933
MESH:D011471 Prostatic Neoplasms bisphenol A 3.1516740699
MESH:D011471 Prostatic Neoplasms Copper 3.1517308104 17079463
MESH:D011471 Prostatic Neoplasms Cyclophosphamide 3.1517136230
MESH:D011471 Prostatic Neoplasms Diethylstilbestrol 3.1517136230 15846301 15046698
MESH:D011471 Prostatic Neoplasms Doxorubicin 3.1516868541 16729912 15749863 15897917 16888761 18437689
MESH:D011471 Prostatic Neoplasms Estradiol 3.1516740699
MESH:D011471 Prostatic Neoplasms Genistein 3.1515256057 15378649 16925846
MESH:D011471 Prostatic Neoplasms Quercetin 3.1517292933 14715546
MESH:D011471 Prostatic Neoplasms resveratrol 3.1516731767 17675339 17804756 17636462 17718901 15767336
MESH:D011507 Proteinuria Tretinoin 3.0516636307
MESH:D011565 Psoriasis Cyclosporine 1.9816882103
MESH:D011618 Psychotic Disorders Cocaine 4.3716134406
MESH:D011625 Pterygium Tretinoin 4.1816723453
MESH:D011629 Puberty, Precocious bisphenol A 4.1810548101
MESH:D011654 Pulmonary Edema Isoproterenol 4.6310903255
MESH:D011658 Pulmonary Fibrosis Cyclophosphamide 5.0816636934
MESH:D011658 Pulmonary Fibrosis Paraquat 5.0816324872 17997886
MESH:D011833 Radiation Injuries, Experimental mangiferin 5.7815830843
MESH:D051437 Renal Insufficiency Doxorubicin 3.6317922066
MESH:D051436 Renal Insufficiency, Chronic resveratrol 4.9616325855
MESH:D015427 Reperfusion Injury pirinixic acid 5.4519058328
MESH:D015427 Reperfusion Injury resveratrol 5.4517058453 17520802 16317513 16314181 15827377
MESH:D012128 Respiratory Distress Syndrome, Adult Paraquat 3.3511700416
MESH:D012130 Respiratory Hypersensitivity Lipopolysaccharides 3.3110835634
MESH:D012135 Respiratory Sounds Paraquat 3.4711874814
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.2618990726
MESH:D012162 Retinal Degeneration Paraquat 3.4016458197
MESH:D012208 Rhabdomyosarcoma Tretinoin 3.5416116481 16283617
MESH:D012509 Sarcoma Doxorubicin 3.4616767912 17710206 18313854 17203757 15625365 15675481
MESH:D012512 Sarcoma, Ewing's Doxorubicin 3.6616326096 14601052
MESH:D012514 Sarcoma, Kaposi Doxorubicin 4.1817846226
MESH:D012554 Schistosomiasis japonica Quercetin 4.9216862918
MESH:D012559 Schizophrenia Copper 2.9916842975
MESH:D012595 Scleroderma, Systemic Cyclophosphamide 4.2616636934
MESH:D012640 Seizures Cocaine 5.8210454489
MESH:D012640 Seizures Mecamylamine 5.8212660363
MESH:D012772 Shock, Septic endotoxin, Escherichia coli 9.4918063050
MESH:D012772 Shock, Septic mangiferin 9.4915177305
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 14.4619755658 10029692
MESH:D012878 Skin Neoplasms Doxorubicin 14.4615692506
MESH:D012878 Skin Neoplasms resveratrol 14.4615837718 8985016
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 14.4616192470
MESH:D012878 Skin Neoplasms Tretinoin 14.4616467112
MESH:D012983 Soft Tissue Neoplasms Doxorubicin 3.9717203757 15625365 16767912
MESH:D013088 Spermatocele Diethylstilbestrol 4.0916002989 16709447
OMIM:102530 SPERMATOGENIC FAILURE 6 Cyclophosphamide 4.9016517039
MESH:D013158 Splenic Diseases Dimethylnitrosamine 4.6512587719
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 4.0720155912 2093021
MESH:D013274 Stomach Neoplasms Dimethylnitrosamine 4.0716033868
MESH:D013274 Stomach Neoplasms nitrosobenzylmethylamine 4.0717575124 12958204
MESH:D013274 Stomach Neoplasms Tretinoin 4.0717261132
MESH:D013276 Stomach Ulcer mangiferin 3.7517918041
OMIM:601367 STROKE, ISCHEMIC resveratrol 3.9416321402
MESH:D019966 Substance-Related Disorders bisphenol A 3.3816684133 16045194
MESH:D013436 Sulfhemoglobinemia Phenacetin 5.93978859
MESH:D015173 Supratentorial Neoplasms Cyclophosphamide 4.4512837982
MESH:D013921 Thrombocytopenia Lipopolysaccharides 3.6315821434
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.2812697716
MESH:D013964 Thyroid Neoplasms Doxorubicin 5.7516010429 17909728
MESH:D013964 Thyroid Neoplasms Tretinoin 5.7517045167 16026305
MESH:D013978 Tibial Fractures Estradiol 4.0619048282
MESH:D014062 Tongue Neoplasms resveratrol 8.1416227395
MESH:D014062 Tongue Neoplasms Tretinoin 8.1416051514
MESH:D014235 Trichinellosis mangiferin 5.4414669257
MESH:D014376 Tuberculosis Tretinoin 2.8216040207
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 16.2317053015
MESH:D001749 Urinary Bladder Neoplasms Cyclophosphamide 16.2314692829
MESH:D001749 Urinary Bladder Neoplasms Diethylstilbestrol 16.2316712894 16452187 17306315
MESH:D001749 Urinary Bladder Neoplasms Doxorubicin 16.2317653716
MESH:D001749 Urinary Bladder Neoplasms Phenacetin 16.2311144890
MESH:D001749 Urinary Bladder Neoplasms Quercetin 16.2316720314
MESH:D014581 Urticaria Acetaminophen 2.4210982225
MESH:D002583 Uterine Cervical Neoplasms Diethylstilbestrol 18.3416175088
MESH:D002583 Uterine Cervical Neoplasms indole-3-carbinol 18.3416082211
MESH:D002583 Uterine Cervical Neoplasms resveratrol 18.3417473185
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 18.3416129372
MESH:D014591 Uterine Diseases bisphenol A 11.7514652134
MESH:D014591 Uterine Diseases Diethylstilbestrol 11.7514652134
MESH:D014594 Uterine Neoplasms Diethylstilbestrol 7.8616690809 15809267
MESH:D014594 Uterine Neoplasms resveratrol 7.8617044934
MESH:D014604 Uveal Neoplasms Tretinoin 3.9916752155
MESH:D014605 Uveitis Cyclosporine 3.361336536
MESH:D014625 Vaginal Neoplasms Diethylstilbestrol 3.8416513791 16002989
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 3.9712125929
MESH:D018487 Ventricular Dysfunction, Left Doxorubicin 13.8717334414 17638931 17678736 16364871
MESH:D018487 Ventricular Dysfunction, Left Isoproterenol 13.8718097624
MESH:D018487 Ventricular Dysfunction, Left resveratrol 13.8717488730
MESH:D020257 Ventricular Remodeling Isoproterenol 5.0818097624
MESH:D014820 Vitiligo Tretinoin 3.4816761959
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 3.6315886252
MESH:D015430 Weight Gain Dietary Fats 3.2216723640
MESH:D009396 Wilms Tumor Tretinoin 3.4516287080
MESH:D014985 Xerophthalmia Cyclosporine 3.8217120751
Pathway ID Pathway Name
KEGG:04142 Lysosome
KEGG:05152 Tuberculosis
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA27029
    • No data
    Releated disease ID Related disease Name
    PA446858Neurodegenerative Diseases
    PA443319Alzheimer Disease
    Releated drug ID Related drug Name
    PA449780glutathione
    PA164768822chlorotrianisene
    PA164754789conjugated estrogens
    PA164745534dienestrol
    PA449307diethylstilbestrol
    PA449503estradiol
    PA449509estrogens
    PA449512estrone
    PA449527ethinyl estradiol
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB00030 - Insulin recombinant Hypoglycemic Agents
    DB00071 - Insulin, porcine Hypoglycemic Agents
    DB02216 - S-Methylcysteine
    DB02944 - Alpha-D-Mannose
    DB03028 - 1h-Benoximidazole-2-Carboxylic Acid
    DB03096 - N-Aminoethylmorpholine
    DB07542 - 5-AMINO-6-CYCLOHEXYL-4-HYDROXY-2-ISOBUTYL-HEXANOIC ACID
    DB08740 - CYCLOHEXYLMETHYL-2,3-DIHYDROXY-5-METHYL-HEXYLAMIDE
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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