AutismKB 2.0

Annotation Detail for ADRA2B


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Basic Information Top
Gene Symbol:ADRA2B ( ADRA2L1,ADRA2RL1,ADRARL1,ALPHA2BAR )
Gene Full Name: adrenergic, alpha-2B-, receptor
Band: 2q11.2
Quick LinksEntrez ID:151; OMIM: 104260; Uniprot ID:ADA2B_HUMAN; ENSEMBL ID: ENSG00000222040; HGNC ID: 282
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04080Neuroactive ligand-receptor interaction
Pathway IDPathway Name
Signaling by GPCR
Hemostasis
No data
Pathway IDPathway Name
P00026Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
P00002Alpha adrenergic receptor signaling pathway
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1856Obesity
1904Diabetes mellitus
2091Hypertension
2102Polycystic ovary syndrome
Desease Name
flow-mediated dilation of the brachial artery
glucose
CARDIOVASCULAR
myocardial infarct
body mass
cardiac death
hypertension
nervous system activity
METABOLIC
heart rate
obesity
insulin
diabetes, type 2
intima-media thickness
ANS function
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000109 Acetylcholine ADRA2B protein affects the susceptibility to [Phenylephrine co-treated with Acetylcholine]affects cotreatment|affects response to substance 16815979
D000643 Ammonium Chloride Ammonium Chloride affects the expression of ADRA2B mRNAaffects expression 16483693
C006632 arsenic trioxide arsenic trioxide results in decreased expression of ADRA2B mRNAdecreases expression 19128835
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of ADRA2B mRNAdecreases expression 20064835
D002251 Carbon Tetrachloride Carbon Tetrachloride results in decreased expression of ADRA2B mRNAdecreases expression 17484886
D002251 Carbon Tetrachloride Carbon Tetrachloride results in decreased expression of ADRA2B proteindecreases expression 12629582
D003993 Dibutyl Phthalate Dibutyl Phthalate results in decreased expression of ADRA2B mRNAdecreases expression 15620428
D004026 Dieldrin Dieldrin results in decreased expression of ADRA2B mRNAdecreases expression 18812211
D005038 Ethylnitrosourea Ethylnitrosourea results in increased mutagenesis of ADRA2B geneincreases mutagenesis 16495775
D010656 Phenylephrine ADRA2B protein affects the susceptibility to Phenylephrineaffects response to substance 16815979
D010656 Phenylephrine ADRA2B protein affects the susceptibility to [Phenylephrine co-treated with Acetylcholine]affects cotreatment|affects response to substance 16815979
C025299 polyphenols polyphenols results in decreased expression of ADRA2B mRNAdecreases expression 16293270
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 3.8018287403
MESH:D000230 Adenocarcinoma arsenic trioxide 4.4819825857 11798837
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 4.4820464547 20127859
MESH:D000236 Adenoma Benzo(a)pyrene 7.266695378
MESH:D000236 Adenoma Ethylnitrosourea 7.266695378
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.2919183758
MESH:D001145 Arrhythmias, Cardiac Phenylephrine 4.2717460149
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 3.8416206674
MESH:D001919 Bradycardia Phenylephrine 4.7815306635
MESH:D001927 Brain Diseases Ethylnitrosourea 5.0414991843
MESH:D001932 Brain Neoplasms Ethylnitrosourea 4.4515144691 16651633 16436596 16357521 18412241
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.4817474063 20146248
MESH:D001943 Breast Neoplasms Dieldrin 2.4811859874 15770527
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.5111589617
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.9910355542 15673190 18705752 3786805 16124888 16050911 16097048 16227642 16011737 16192424 15700767 15721981
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 3.1215073043 16217749 14691202 11135700 15553829
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 3.1218788625
MESH:D002291 Carcinoma, Papillary arsenic trioxide 5.1419014326
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 4.2812490120
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 2.0920419170
MESH:D006332 Cardiomegaly Phenylephrine 3.6217124262 11754973 11179087 15728586 17287366 16170337
MESH:D002471 Cell Transformation, Neoplastic Ethylnitrosourea 3.8416003739
MESH:D016543 Central Nervous System Neoplasms Ethylnitrosourea 6.2517160924
MESH:D003110 Colonic Neoplasms polyphenols 2.7016293270
MESH:D015179 Colorectal Neoplasms arsenic trioxide 1.8620501625
MESH:D023903 Coronary Restenosis arsenic trioxide 4.3812609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 1.8910525206
MESH:D003456 Cryptorchidism Dibutyl Phthalate 5.6516037377
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 4.2815213294
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 4.313786805 10915739 3732212 7440962 15027814 2869522 7179309 21278145 19336974 4309450 11566570 16177239 7120509 17522070 10092053 19085960 6884620 15998439 15968718 6623471 9327722 16227642
MESH:D056486 Drug-Induced Liver Injury polyphenols 4.3119370779
MESH:D004476 Ectodermal Dysplasia Ethylnitrosourea 6.2518357618
MESH:D004938 Esophageal Neoplasms arsenic trioxide 4.5612903497
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.5616530937
MESH:D005234 Fatty Liver arsenic trioxide 8.4415073043
MESH:D005234 Fatty Liver Carbon Tetrachloride 8.4461145 15959796 17595544 12795759 16239168 16045604 19224547 12631006
MESH:D005355 Fibrosis Carbon Tetrachloride 3.6718705752
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.4616904648
MESH:D005909 Glioblastoma Ethylnitrosourea 3.9416436596
MESH:D005910 Glioma Ethylnitrosourea 3.5516357521 18412241 16651633
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 2.7420471113
MESH:D006505 Hepatitis Carbon Tetrachloride 3.7919110552 19900420
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.7716899240
MESH:D006973 Hypertension Phenylephrine 3.1312717712 8949925
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.3015338365
MESH:D006984 Hypertrophy Phenylephrine 4.7318502941 12791704
MESH:D007247 Infertility, Female Dieldrin 5.1210630421
MESH:D007249 Inflammation polyphenols 3.1416366677
MESH:D007680 Kidney Neoplasms Ethylnitrosourea 4.0717379185
MESH:D007938 Leukemia arsenic trioxide 2.9115070760
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 3.9712560223 17077332
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.5416972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.5514633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 3.9319077051
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 2.1616968895 16467208 20471514 17050201 19850784
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 3.3217712046 12018890 9834237 16966277 19642359 17217047 11468182 12679006 15748426 17869043 19035177 19225113 15336539 11161223 16331271 17649720 16330433 19075265 17107899 16823087 16112521 16891316 12712474 15622746 15213294
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.5516882451
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 2.8916239168 17157831 11408273 16943688 17334410 16221502 11903743 21278145 17174718
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 1.7515338365 17714472 17766677 15818738 15996030 15730626 15673190 12649538 12667390 18251166 16248980 18277467 12632512 18376398 18187930 18472094 18339082 12546737 12586293 14748882 17631135 16136751 15123356 18472332 18210741 17869086 16192424 12898905 17761835 12632514 17708605 17481882 12741479 17823541 13678700 12666154 18205269 15370692 17805973 17557913 15362042 17922224 18279442 18412020 17721639 16638106 10355542 18395914 12958196 15931870 15959796 17944888 12389079 12445421 14716833 17698563 16097048 18420326 15893842 18418968 18156304 18263696 18395095 18481824 18006644 14724832 17525996 14512876 15925388 18705752 15052691 14716496 14620537 17640975 17976157 15650968 18317297 16033810 18429990 15876570 16015684 11481614 17565644 15057751 17900296 16116963 12445418 12609069 16011737 18166357 20821823 16027843 18054572
MESH:D008107 Liver Diseases Carbon Tetrachloride 4.4516246199 15830285 17285989 15720792 16964402
MESH:D008107 Liver Diseases polyphenols 4.4516698588
MESH:D017093 Liver Failure Carbon Tetrachloride 4.3815123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 3.8516899240 14706259
MESH:D008113 Liver Neoplasms arsenic trioxide 11.2514682389
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 11.2521137059 20195826
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 11.2519294768
MESH:D008113 Liver Neoplasms Dieldrin 11.258742319 9539021
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 6.3320377131
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 6.3312014681 15583823
MESH:D008133 Long QT Syndrome arsenic trioxide 3.4815213294
MESH:D008175 Lung Neoplasms arsenic trioxide 3.6419825857 11798837
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 3.6420464547 20064080 18816296 20869020 18569708 18520028 20135361 6695378 17053015
MESH:D008175 Lung Neoplasms Ethylnitrosourea 3.6416019985 16271038 6695378 17703301
MESH:D008223 Lymphoma Ethylnitrosourea 4.0615790496
MESH:D016399 Lymphoma, T-Cell Ethylnitrosourea 5.2615375218
MESH:D008325 Mammary Neoplasms, Experimental Ethylnitrosourea 3.6110767621 18041768 10838139
MESH:D008579 Meningioma Ethylnitrosourea 6.2517943659
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.3216381670
MESH:D009101 Multiple Myeloma arsenic trioxide 3.2214977855 11468182 19417148 15949261 19549372
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.9418349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 3.2316105982 16882451
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 4.1616624393
MESH:D009369 Neoplasms Benzo(a)pyrene 5.6411141357
MESH:D009369 Neoplasms Dieldrin 5.648820588
MESH:D009374 Neoplasms, Experimental Ethylnitrosourea 4.6216707424
MESH:D009436 Neural Tube Defects arsenic trioxide 3.2210525206
MESH:D009442 Neurilemmoma Ethylnitrosourea 5.6516003739 16651423 17160924
MESH:D009837 Oligodendroglioma Ethylnitrosourea 6.2517160924
MESH:D010051 Ovarian Neoplasms arsenic trioxide 2.4519769630 12452020 16624393
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 2.5815580305
MESH:D010235 Paraganglioma arsenic trioxide 4.3519927285
MESH:D010300 Parkinson Disease Dieldrin 3.5816112328 11181820 16809432 11445065 17291500
MESH:D011471 Prostatic Neoplasms arsenic trioxide 3.1419131511
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 3.1417292933
MESH:D012130 Respiratory Hypersensitivity Acetylcholine 4.359413022
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 4.1616646077
MESH:D012852 Sinusitis Phenylephrine 4.947327846
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 2.4419755658 10029692
MESH:D013274 Stomach Neoplasms arsenic trioxide 2.4017007042
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 2.402093021 20155912
MESH:D013705 Temporomandibular Joint Disorders polyphenols 5.5217997062
MESH:D013953 Thymus Neoplasms Ethylnitrosourea 5.4015790496
MESH:D013964 Thyroid Neoplasms arsenic trioxide 3.2219014326
MESH:D016171 Torsades de Pointes arsenic trioxide 4.2015213294
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 5.2420435036 11780464 12845720 12973940
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 5.2417053015
Pathway ID Pathway Name
REACT:604 Hemostasis
KEGG:04080 Neuroactive ligand-receptor interaction
REACT:14797 Signaling by GPCR
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA36
    • Releated gene ID Related gene Name
    PA36ADRA2B
    Releated disease ID Related disease Name
    PA443309Alcoholism
    Releated drug ID Related drug Name
    PA449256dexmedetomidine
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB00217 agonist Bethanidine Antihypertensive Agents;Adrenergic Agents;Sympatholytics
    DB00246 antagonist Ziprasidone Antipsychotics;Dopamine Antagonists;Serotonin Antagonists;Antipsychotic Agents
    DB00248 antagonist Cabergoline Antineoplastic Agents;Antiparkinson Agents;Dopamine Agonists
    DB00268 agonist Ropinirole Central Nervous System Agents;Antiparkinson Agents;Antidyskinetics;Dopamine Agonists
    DB00292 agonist Etomidate Hypnotics and Sedatives;Anesthetics, Intravenous
    DB00334 antagonist Olanzapine Antiemetics;Antipsychotics;Antipsychotic Agents;Serotonin Uptake Inhibitors
    DB00363 antagonist Clozapine Antipsychotics;Serotonin Antagonists;Antipsychotic Agents;GABA Antagonists
    DB00368 agonist Norepinephrine Vasoconstrictor Agents;Sympathomimetics;Adrenergic alpha-Agonists
    DB00413 unknown Pramipexole Antioxidants;Free Radical Scavengers;Antiparkinson Agents;Antidyskinetics;Dopamine Agonists
    DB00484 agonist Brimonidine Antihypertensive Agents;EENT Drugs;Adrenergic alpha-Agonists
    DB00575 agonist Combipres 0.1/15 Tab Antihypertensive Agents;Analgesics;Sympatholytics;Adrenergic alpha-Agonists;Central Alpha-Agonists
    DB00589 other/unknown Lisuride Antiparkinson Agents;Antidyskinetics;Dopamine Agonists;Serotonin Agonists
    DB00668 agonist Zorcaine Vasoconstrictor Agents;Sympathomimetics;Adrenergic alpha-Agonists;Mydriatics;Bronchodilator Agents;Adrenergic beta-Agonists;Adrenergic Agonists
    DB00696 partial agonist Wigraine Tab Vasoconstrictor Agents;Sympatholytics;Adrenergic alpha-Agonists;Analgesics, Non-Narcotic
    DB00697 agonist Tizanidine Muscle Relaxants;Skeletal Muscle Relaxants;Anticonvulsants;Analgesics;Adrenergic alpha-Agonists;Muscle Relaxants, Central;Parasympatholytics
    DB00714 agonist Homeopathic Remedy Thc No. 48 Dps Antiparkinson Agents;Antidyskinetics;Dopamine Agonists
    DB00726 other/unknown Trimipramine Antidepressants;Adrenergic Uptake Inhibitors;Antidepressive Agents, Tricyclic;Norepinephrine-Reuptake Inhibitors
    DB00734 agonist Risperidone Antipsychotics;Dopamine Antagonists;Serotonin Antagonists;Antipsychotic Agents
    DB00800 antagonist Fenoldopam Antihypertensive Agents;Vasodilator Agents;Dopamine Agonists
    DB00925 antagonist Phenoxybenzamine Antihypertensive Agents;Vasodilator Agents;Adrenergic alpha-Antagonists
    DB01142 antagonist Doxepin Antidepressants;Anti-anxiety Agents;Antipruritics;Antidepressive Agents, Tricyclic;Norepinephrine-Reuptake Inhibitors;Histamine Antagonists
    DB01186 agonist Pergolide Central Nervous System Agents;Antiparkinson Agents;Antidyskinetics;Dopamine Agonists;Neuroprotective Agents
    DB01200 agonist Bromocriptine Antiparkinson Agents;Antidyskinetics;Dopamine Agonists;Hormone Antagonists
    DB01224 antagonist Quetiapine Antipsychotics;Antipsychotic Agents
    DB01238 other/unknown Aripiprazole Antipsychotics;Antipsychotic Agents
    DB01267 antagonist Paliperidone Antipsychotic Agents
    DB01363 agonist Tartephedreel
    DB01392 antagonist Yohimbine Mydriatics;Adrenergic alpha-Antagonists
    DB01403 antagonist Methotrimeprazine Dopamine Antagonists;Analgesics, Non-Narcotic;Antipsychotic Agents
    DB01577 agonist Methamphetamine Adrenergic Agents;Dopamine Agents;Dopamine Uptake Inhibitors;Adrenergic Uptake Inhibitors;Central Nervous System Stimulants;Sympathomimetics
    DB06262 agonist Droxidopa Vasoconstrictor Agents;Sympathomimetics;Adrenergic alpha-Agonists
    DB06694 agonist Xylometazoline Sympathomimetics;Adrenergic alpha-Agonists;Nasal Decongestants
    No data
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    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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