AutismKB 2.0

Annotation Detail for CTSG


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Basic Information Top
Gene Symbol:CTSG ( CG,MGC23078 )
Gene Full Name: cathepsin G
Band: 14q12
Quick LinksEntrez ID:1511; OMIM: 116830; Uniprot ID:CATG_HUMAN; ENSEMBL ID: ENSG00000100448; HGNC ID: 2532
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04080Neuroactive ligand-receptor interaction
hsa04142Lysosome
hsa05146Amoebiasis
hsa05322Systemic lupus erythematosus
hsa04614Renin-angiotensin system
Pathway IDPathway Name
Diabetes pathways
No data
No data
Pathway IDPathway Name
500133Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Protei
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1781Rheumatoid arthritis
1803Periodontitis
1818Systemic scleroderma
2029Tuberculosis
2051Leukemia
2075Heart failure
Desease Name
cardiovascular disease
CARDIOVASCULAR
cerebrovascular disease
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of CTSG mRNAaffects expression 17562736
D000814 Aniline Compounds CTSG protein results in increased hydrolysis of Aniline Compounds analogincreases hydrolysis 6566611
D000814 Aniline Compounds CTSG protein results in increased hydrolysis of Aniline Compounds analogincreases hydrolysis 6566611
D004317 Doxorubicin CTSG affects the susceptibility to Doxorubicinaffects response to substance 16458935
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of CTSG mRNAincreases expression 16114106
D014212 Tretinoin Tretinoin results in decreased expression of CTSG mRNAdecreases expression 17218384
D014212 Tretinoin Tretinoin results in decreased expression of CTSG mRNAdecreases expression 16604517
C034028 vanadyl sulfate vanadyl sulfate results in increased expression of CTSG mRNAincreases expression 16330358
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.3115322242 11752688 14514962
MESH:D000230 Adenocarcinoma Doxorubicin 2.6317418594
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.8416835633
MESH:D000419 Albuminuria Doxorubicin 4.9321441931
MESH:D000505 Alopecia Tretinoin 3.8715955085
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.2511748828
MESH:D000799 Angioedema Acetaminophen 4.3610982225
MESH:D001169 Arthritis, Experimental Tretinoin 3.2516412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.3216292516
MESH:D001249 Asthma Tretinoin 2.4216456186
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001471 Barrett Esophagus Tretinoin 4.7816935849
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 10.0412125929
MESH:D001778 Blood Coagulation Disorders Tretinoin 10.0416206674 16197459
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.3115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.9515746008
MESH:D019046 Bone Marrow Neoplasms Doxorubicin 5.2214601052
MESH:D001932 Brain Neoplasms Doxorubicin 4.1117150277
MESH:D001943 Breast Neoplasms Doxorubicin 1.8816264153 15567936 16096432 15994142 18628466 16115903 15939500 16826403 18695136 16935488 18234424 15993339 19526202 16322301 11325840 15692762 18382427 16595493 17426702 17983394 17369602 15668708 15634643 15136595
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.8820435547
MESH:D001943 Breast Neoplasms Tretinoin 1.8816166294 16443354 16873071
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 5.0516813970
MESH:D002276 Carcinoid Tumor Doxorubicin 5.3316051944
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 3.0516835633
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.6816168501
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 4.813084413
MESH:D006528 Carcinoma, Hepatocellular Doxorubicin 4.8116234567 16023760 18059187 17876044
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 4.811917145
MESH:D002292 Carcinoma, Renal Cell Doxorubicin 3.2816201981 1485588
MESH:D002294 Carcinoma, Squamous Cell Doxorubicin 5.036189445
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 5.0316051514 16096774
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.5216120746 18670907 18850075
MESH:D009202 Cardiomyopathies Doxorubicin 3.7217924179 17308081 17007740 16731534 15792986 16612575 16952015 15505089 17974986 16651473 16278810 17519947 15811867 17131338 17928571 17329180 16242529 16364871 16455267 15476868 18627295 16109756 16269455 17351982 17382496
MESH:D002311 Cardiomyopathy, Dilated Doxorubicin 3.0317334414 16243910
MESH:D002386 Cataract Acetaminophen 7.7810977129
MESH:D002386 Cataract Tretinoin 7.7817460283
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 5.0516129372
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.4516835633
MESH:D002822 Choriocarcinoma Tretinoin 5.6816461808
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 6.1312621046 15668235 16354765 8697196 15340226
MESH:D002972 Cleft Palate Tretinoin 6.139407595
MESH:D003092 Colitis Tretinoin 4.1217035595
MESH:D015179 Colorectal Neoplasms Doxorubicin 2.1518802399 18259882
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.3417141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.5215322242 20055451 10048152
MESH:D019465 Craniofacial Abnormalities Tretinoin 2.529224671 9664655 8800419 14991402 9211117 10589399 16925845 17551590 9142499 9125849
MESH:D003921 Diabetes Mellitus, Experimental vanadyl sulfate 4.6416684804
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7217107852
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 6.6316227642 14725611 12594235 16781746 19085960 11739529 11287661 11743745 11421492 12705907 15619225 11529661 16177239 16393943 16081117 18713872 11834606 12540782 17906064 10663392 19739265 10774834 19416960 14550746 12958197 17562736 16109766 19370779 14986274 16485898 17522070 2444490 10915739 19923254 11461765 12392966 15968718 12153990 19164858 18071297 19420014
MESH:D056486 Drug-Induced Liver Injury Doxorubicin 6.6317416283
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 6.6320420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.6219426721
MESH:D004362 Drug Toxicity Doxorubicin 8.8918602426
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 8.8911462148
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.7012711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 13.7415322242 18230668 16714409
MESH:D004489 Edema, Cardiac Tretinoin 13.7418230668
MESH:D016889 Endometrial Neoplasms Doxorubicin 8.2317359293
MESH:D016889 Endometrial Neoplasms Tretinoin 8.2316569247
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.339294722 10568697
MESH:D004719 Endomyocardial Fibrosis Doxorubicin 5.6818037988
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 9.6111564622
MESH:D005124 Eye Abnormalities Tretinoin 9.6116938888 9664655
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.8711858732
MESH:D018222 Fibromatosis, Aggressive Doxorubicin 5.0519069698
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 10.0420067830
MESH:D005355 Fibrosis Tretinoin 10.0417994277
MESH:D005756 Gastritis Acetaminophen 4.1916983495
MESH:D005909 Glioblastoma Doxorubicin 7.8917150277
MESH:D005909 Glioblastoma Tretinoin 7.8917312396
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 5.1210696789
MESH:D006258 Head and Neck Neoplasms Doxorubicin 8.5215692506
MESH:D006258 Head and Neck Neoplasms Tretinoin 8.5216096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.6816084493
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 7.0211294989 10048152
MESH:D006330 Heart Defects, Congenital Tretinoin 7.029664655 14991402
MESH:D006331 Heart Diseases Doxorubicin 3.6918006777 12587719 16495754 16144979 17875725 16707910 16879835 18674790 16244372 16244371 14766674 17888722 16330681
MESH:D006333 Heart Failure Doxorubicin 3.5217481944
MESH:D006394 Hemangiosarcoma Doxorubicin 4.2315692506
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.6611000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.3112621046 15340226 16120746
MESH:D006689 Hodgkin Disease Doxorubicin 3.6917606976 18501091 15147373
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.5716959395 15340226 18606429 8697196 16354765
MESH:D006930 Hyperalgesia Acetaminophen 8.4816870215
MESH:D006930 Hyperalgesia Tretinoin 8.4816870215
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.9916778211
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 2.0018850075 18670907
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 1.9912200463 12878042
MESH:D007410 Intestinal Diseases Tretinoin 4.1817994277
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 11.0416580747
MESH:D007569 Jaw Abnormalities Tretinoin 11.0415992940 17551590
MESH:D007674 Kidney Diseases Acetaminophen 6.6115629191 12587719
MESH:D007674 Kidney Diseases Doxorubicin 6.6116775033 15369732 15699352
MESH:D007676 Kidney Failure, Chronic Doxorubicin 4.4816707910
MESH:D007938 Leukemia Tretinoin 2.9017143497
MESH:D004915 Leukemia, Erythroblastic, Acute Doxorubicin 5.6816085563
MESH:D007951 Leukemia, Myeloid Tretinoin 4.0216932348 16482212 19285840
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 2.1217596541 16294345 19850784
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 3.3419225113 15748426 16891316 17361223 17649720 17712046 17294898 16766008 19029980 9834237 16823087 19642359 17301526 19075265 16140955 16331271 12679006 19035177 17506722 17339181 17217047 17107899 16935935 16788101 17368321
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.539224671
MESH:D008106 Liver Cirrhosis, Experimental Doxorubicin 3.6616595196 16439617
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.6612878042
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 3.6616248980 18397230
MESH:D008107 Liver Diseases Acetaminophen 1.6919460945 16610002 19014921 11587558 12969438 12587719 16611625 19784758
MESH:D017114 Liver Failure, Acute Acetaminophen 3.5416871587 17185352
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 1.8116984957
MESH:D008114 Liver Neoplasms, Experimental Doxorubicin 6.5217085340 16842330
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 6.5212151625
MESH:D008175 Lung Neoplasms Doxorubicin 2.4717418594 6189445
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 2.4711884234 19555203
MESH:D008223 Lymphoma Doxorubicin 3.6816098063
MESH:D008228 Lymphoma, Non-Hodgkin Doxorubicin 4.0617654614
MESH:D016399 Lymphoma, T-Cell Doxorubicin 4.9815621674
MESH:D008325 Mammary Neoplasms, Experimental Doxorubicin 3.2115458769
MESH:D008527 Medulloblastoma Tretinoin 2.8817453147
MESH:D008545 Melanoma Doxorubicin 3.5716827129
MESH:D008545 Melanoma Tretinoin 3.5716752155
MESH:D008546 Melanoma, Experimental Acetaminophen 3.9819513568
MESH:D008591 Meningomyelocele Tretinoin 4.8416940565
MESH:D008654 Mesothelioma Doxorubicin 3.1617638057
MESH:D028361 Mitochondrial Diseases Doxorubicin 4.8315792986
MESH:D052016 Mucositis Doxorubicin 5.2517415656
MESH:D009190 Myelodysplastic Syndromes Tretinoin 3.2417596541
MESH:D009203 Myocardial Infarction Doxorubicin 3.0515857846 19429709
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.2712213967
MESH:D009362 Neoplasm Metastasis Doxorubicin 3.0518259882
MESH:D009369 Neoplasms Tretinoin 2.5416946489 16594593
MESH:D009401 Nephrosis Doxorubicin 5.1916636307 16899518
MESH:D009404 Nephrotic Syndrome Doxorubicin 4.2916889571 15640375
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 10.8114600291
MESH:D009421 Nervous System Malformations Tretinoin 10.819125849
MESH:D009436 Neural Tube Defects Tretinoin 3.249142499
MESH:D009447 Neuroblastoma Doxorubicin 3.4015555623
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.1418514411
MESH:D012516 Osteosarcoma Doxorubicin 4.3715930896
MESH:D010051 Ovarian Neoplasms Tretinoin 2.4216936753
MESH:D010146 Pain Acetaminophen 7.4916870215
MESH:D010146 Pain Tretinoin 7.4916870215
MESH:D010190 Pancreatic Neoplasms Tretinoin 2.5515976015
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.7712520081
MESH:D003557 Phyllodes Tumor Doxorubicin 5.6817983394
MESH:D010997 Pleural Neoplasms Doxorubicin 5.6817638057
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.9418163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.6511896295 11222880 11118676 11399792
MESH:D011471 Prostatic Neoplasms Doxorubicin 3.5016868541 15897917 15749863 16729912 18437689 16888761
MESH:D011507 Proteinuria Tretinoin 3.9516636307
MESH:D011625 Pterygium Tretinoin 5.2616723453
MESH:D051437 Renal Insufficiency Doxorubicin 4.6417922066
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.2218990726
MESH:D012208 Rhabdomyosarcoma Tretinoin 4.4516283617 16116481
MESH:D012509 Sarcoma Doxorubicin 4.2917203757 17710206 15675481 15625365 18313854 16767912
MESH:D012512 Sarcoma, Ewing's Doxorubicin 4.6216326096 14601052
MESH:D012514 Sarcoma, Kaposi Doxorubicin 5.2517846226
MESH:D012878 Skin Neoplasms Doxorubicin 10.2215692506
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 10.2216192470
MESH:D012878 Skin Neoplasms Tretinoin 10.2216467112
MESH:D012983 Soft Tissue Neoplasms Doxorubicin 4.9815625365 17203757 16767912
MESH:D013274 Stomach Neoplasms Tretinoin 1.8017261132
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.4212697716
MESH:D013964 Thyroid Neoplasms Doxorubicin 8.1216010429 17909728
MESH:D013964 Thyroid Neoplasms Tretinoin 8.1217045167 16026305
MESH:D014062 Tongue Neoplasms Tretinoin 4.0916051514
MESH:D014376 Tuberculosis Tretinoin 3.4116040207
MESH:D001749 Urinary Bladder Neoplasms Doxorubicin 2.8617653716
MESH:D014581 Urticaria Acetaminophen 3.3310982225
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 3.9816129372
MESH:D014604 Uveal Neoplasms Tretinoin 5.1316752155
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 5.1212125929
MESH:D018487 Ventricular Dysfunction, Left Doxorubicin 4.6417678736 16364871 17638931 17334414
MESH:D014820 Vitiligo Tretinoin 4.4416761959
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.7715886252
MESH:D009396 Wilms Tumor Tretinoin 4.2516287080
Pathway ID Pathway Name
KEGG:05146 Amoebiasis
REACT:15380 Diabetes pathways
KEGG:04142 Lysosome
KEGG:04080 Neuroactive ligand-receptor interaction
KEGG:04614 Renin-angiotensin system
KEGG:05322 Systemic lupus erythematosus
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA27032
    • No data
    Releated disease ID Related disease Name
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    Releated drug ID Related drug Name
    PA450379mercaptopurine
    PA450428methotrexate
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB02360 - Bis-Napthyl Beta-Ketophosphonic Acid
    DB04016 - 2-[3-({Methyl[1-(2-Naphthoyl)Piperidin-4-Yl]Amino}Carbonyl)-2-Naphthyl]-1-(1-Naphthyl)-2-Oxoethylphosphonic Acid
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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