AutismKB 2.0

Annotation Detail for KLHL23


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Basic Information Top
Gene Symbol:KLHL23 ( DITHP,FLJ37812,MGC22679,MGC2610 )
Gene Full Name: kelch-like 23 (Drosophila)
Band: 2q31.1
Quick LinksEntrez ID:151230; OMIM: NA; Uniprot ID:KLH23_HUMAN; ENSEMBL ID: ENSG00000213160; HGNC ID: 27506
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of KLHL23 mRNAaffects expression 21346803
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of KLHL23 mRNAdecreases expression 20018196
D016572 Cyclosporine Cyclosporine results in decreased expression of KLHL23 mRNAdecreases expression 20106945
D004040 Dietary Carbohydrates Dietary Carbohydrates results in decreased expression of KLHL23 mRNAdecreases expression 17490981
D006830 Hydralazine [Hydralazine co-treated with Valproic Acid] results in increased expression of KLHL23 mRNAaffects cotreatment|increases expression 17183730
D010634 Phenobarbital NR1I3 protein affects the reaction [Phenobarbital results in increased expression of KLHL23 mRNA]affects reaction|increases expression 19482888
D010634 Phenobarbital Phenobarbital results in increased expression of KLHL23 mRNAincreases expression 19482888
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of KLHL23 mRNAdecreases expression 20106945
D014635 Valproic Acid [Hydralazine co-treated with Valproic Acid] results in increased expression of KLHL23 mRNAaffects cotreatment|increases expression 17183730
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 16.276195326
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 16.2715322242 11752688 14514962
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 16.278875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 4.1719490988
MESH:D018248 Adenoma, Liver Cell Phenobarbital 11.2317620307
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 11.2316835633
MESH:D000550 Amblyopia Valproic Acid 5.6117688650
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.1711748828
MESH:D001008 Anxiety Disorders Valproic Acid 3.7617497229
MESH:D001321 Autistic Disorder Valproic Acid 1.9918177632 18316065 18775368 18940202 16609825 17507914 19460635 18985861 17157402 15238991 18396377 18558336 17688650 20603192 19232924
MESH:D001714 Bipolar Disorder Valproic Acid 3.1817594078 20046352
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.2912125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.1715340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 8.5015746008
MESH:D001848 Bone Diseases, Developmental Valproic Acid 8.508888407
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.6820435547
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.9916835633
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 3.1116705839
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 3.116705139 17173139 20007298 1701930 20935162
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4918670907 18850075 16120746
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7.0920889678
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 7.0912371664
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.564080065
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.7820734317
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.3816835633
MESH:D002779 Cholestasis Cyclosporine 3.0919486331
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.198697196 12621046 15340226 15668235 16354765
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.2717141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.5315322242 10048152 20055451
MESH:D019465 Craniofacial Abnormalities Valproic Acid 2.538888407 17688650 16575769
MESH:D003490 Cyanosis 2,4-dinitrotoluene 4.3218551238
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7117107852
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 6.5518551238 21346803
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 6.5520420201
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 6.551733752 19641884
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.9311462148
MESH:D004421 Dystonia Phenobarbital 11.321851702
MESH:D004421 Dystonia Valproic Acid 11.321851702
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.6112711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.2815322242 18230668 16714409
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.2510568697 9294722
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 11.843659116
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 11.8417275665 3659116
MESH:D004828 Epilepsies, Partial Phenobarbital 11.263922381 11558140
MESH:D004828 Epilepsies, Partial Valproic Acid 11.263922381 16628512
MESH:D004827 Epilepsy Phenobarbital 7.0320417680
MESH:D004827 Epilepsy Valproic Acid 7.0318234410 20417680
MESH:D004832 Epilepsy, Absence Phenobarbital 9.596401628
MESH:D004832 Epilepsy, Absence Valproic Acid 9.596426943 6254150 7562514
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 12.357750514
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 12.357750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 11.633659116
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 11.633659116
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.1220426865
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.1911564622
MESH:D005234 Fatty Liver Cyclosporine 8.5719224547
MESH:D005234 Fatty Liver Valproic Acid 8.5714986274 19224547
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.7611858732
MESH:D005315 Fetal Diseases Valproic Acid 5.2616575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 4.418888407 18558336
MESH:D005355 Fibrosis Cyclosporine 9.5212168785 12639820
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 9.5220067830
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.568708960
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.9710696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.4410048152 11294989
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.7615720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.5811000095
MESH:D006529 Hepatomegaly Phenobarbital 9.4816109766
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 9.4816120746 15340226 12621046
MESH:D006849 Hydrocephalus Valproic Acid 5.2017688650
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.428697196 16959395 15340226 16354765 18606429
MESH:D006973 Hypertension Cyclosporine 5.2110903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.2118670907 18850075
MESH:D046110 Hypertension, Pregnancy-Induced Hydralazine 4.9316612254
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 1.9612200463 12878042
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.5816580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.8215604871
MESH:D007674 Kidney Diseases Cyclosporine 2.468314463 10903974 18776723
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 7.9516705839
MESH:D007680 Kidney Neoplasms Cyclosporine 7.9512371664
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 2.1816294345 17596541
MESH:D008103 Liver Cirrhosis Phenobarbital 3.0121047994
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 1.2412878042
MESH:D008107 Liver Diseases Phenobarbital 2.2219363144
MESH:D008113 Liver Neoplasms Phenobarbital 4.6919812893 15975961 19482888 19073162 8742319 21047994
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 4.6916984957
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 6.2617172636 18308698 1399818 6150874 2563599
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 6.2612151625
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 4.6417228818
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 1.2419555203 11884234
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.1616801185
MESH:D008881 Migraine Disorders Valproic Acid 3.3618803445 18765137
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 4.278888407
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 3.2817596541
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.2112213967
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.8117484760
MESH:D009336 Necrosis 2,4-dinitrotoluene 4.2018551238
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.8217954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.5018481113 19348381
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.4914600291
MESH:D009436 Neural Tube Defects Valproic Acid 3.278888407 16359493
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 3.6616049721 12819281
MESH:D010018 Osteomalacia Phenobarbital 4.7017016548
MESH:D010190 Pancreatic Neoplasms Phenobarbital 2.5616965848
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.6212520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.8418163543
MESH:D011230 Precancerous Conditions Cyclosporine 9.6912371664
MESH:D011230 Precancerous Conditions Phenobarbital 9.692563599
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 10.6111222880 11118676 11896295 11399792
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 10.6120603192
MESH:D019310 Pseudolymphoma Phenobarbital 13.4812752131
MESH:D019310 Pseudolymphoma Valproic Acid 13.4811422049 12752131
MESH:D011565 Psoriasis Cyclosporine 2.3016882103
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.1218990726
MESH:D012208 Rhabdomyosarcoma Valproic Acid 4.4419155313
MESH:D012559 Schizophrenia Valproic Acid 2.0919110320 15737665
MESH:D012640 Seizures 2,4-dinitrotoluene 10.7818551238
MESH:D012640 Seizures Phenobarbital 10.783137016 11442880 4039156 16876388
MESH:D012640 Seizures Valproic Acid 10.7814763951 15475178 1511512 16876388 3137016 17978042 11044598 11738929
MESH:D003294 Seizures, Febrile Phenobarbital 5.166407741
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.1416192470
MESH:D016135 Spinal Dysraphism Valproic Acid 3.9619490988
MESH:D013226 Status Epilepticus Valproic Acid 4.9212833885
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.2812697716
MESH:D013964 Thyroid Neoplasms Phenobarbital 3.231399818
MESH:D014178 Translocation, Genetic Valproic Acid 5.6117262798
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.863119515
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 2.3616049721
MESH:D014564 Urogenital Abnormalities Valproic Acid 4.958888407
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 4.6510091137
MESH:D014605 Uveitis Cyclosporine 4.361336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.9712125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.6215886252
MESH:D014985 Xerophthalmia Cyclosporine 4.8217120751
No data
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Syndromic Genes

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AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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