AutismKB 2.0

Annotation Detail for PPP1R1C


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Basic Information Top
Gene Symbol:PPP1R1C ( IPP5 )
Gene Full Name: protein phosphatase 1, regulatory (inhibitor) subunit 1C
Band: 2q31.3-q32.1
Quick LinksEntrez ID:151242; OMIM: 613240; Uniprot ID:PPR1C_HUMAN; ENSEMBL ID: ENSG00000150722; HGNC ID: 14940
Relate to Another Database: SFARIGene; denovo-db
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Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D002251 Carbon Tetrachloride Carbon Tetrachloride results in increased expression of PPP1R1C mRNAincreases expression 12832660
D015946 Ethylene Dibromide Ethylene Dibromide results in decreased expression of PPP1R1C mRNAdecreases expression 15612046
D002117 Calcitriol Calcitriol results in increased expression of PPP1R1C mRNAincreases expression 16002434
D004642 Emodin Emodin results in decreased expression of PPP1R1C mRNAdecreases expression 15612046
C004312 glycidol glycidol results in decreased expression of PPP1R1C mRNAdecreases expression 15612046
D015735 Mifepristone Mifepristone results in increased expression of PPP1R1C mRNAincreases expression 17584828
D015058 1-Naphthylisothiocyanate 1-Naphthylisothiocyanate results in increased expression of PPP1R1C mRNAincreases expression 12832660
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of PPP1R1C mRNAaffects binding|decreases expression|increases activity 19710929
D015125 Oxyquinoline Oxyquinoline results in decreased expression of PPP1R1C mRNAdecreases expression 15612046
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D055371 Acute Lung Injury pirinixic acid 3.3418653653
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.7616434500
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.3519483382
MESH:D001932 Brain Neoplasms glycidol 5.6210528639 12562636
MESH:D001943 Breast Neoplasms Calcitriol 2.4811237771
MESH:D001943 Breast Neoplasms Ethylene Dibromide 2.4811921183
MESH:D001943 Breast Neoplasms glycidol 2.4811921183
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 4.0415700767 3786805 15721981 16124888 15673190 16097048 16227642 16011737 10355542 16192424 16050911 18705752
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 1.8518788625
MESH:D002294 Carcinoma, Squamous Cell Calcitriol 2.6711237771
MESH:D002761 Cholangitis 1-Naphthylisothiocyanate 6.5212912871
MESH:D002779 Cholestasis 1-Naphthylisothiocyanate 8.7815913567 16629650 19486331 12927374 7624871 18590720 18164287 15500046
MESH:D002779 Cholestasis pirinixic acid 8.7819176532
MESH:D002780 Cholestasis, Intrahepatic 1-Naphthylisothiocyanate 6.1719407337 10220858
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5118249437
MESH:D056486 Drug-Induced Liver Injury 1-Naphthylisothiocyanate 6.9818289764 7624871 20133375 17522070
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 6.9815027814 7440962 7179309 2869522 19336974 16177239 11566570 21278145 6623471 3732212 10092053 9327722 6884620 3786805 15998439 7120509 15968718 4309450 17522070 16227642 10915739 19085960
MESH:D056486 Drug-Induced Liver Injury Ethylene Dibromide 6.982862719
MESH:D004487 Edema pirinixic acid 2.6812083418
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Calcitriol 4.1715138306
MESH:D004715 Endometriosis Mifepristone 4.5616134523
MESH:D005234 Fatty Liver Carbon Tetrachloride 8.3717595544 61145 15959796 12631006 16239168 16045604 12795759 19224547
MESH:D005234 Fatty Liver pirinixic acid 8.3720131406 19236843
MESH:D005355 Fibrosis Carbon Tetrachloride 10.1618705752
MESH:D005355 Fibrosis Emodin 10.1619474275
MESH:D006333 Heart Failure pirinixic acid 2.6520558911
MESH:D006505 Hepatitis 1-Naphthylisothiocyanate 10.4618590720
MESH:D006505 Hepatitis Carbon Tetrachloride 10.4619900420 19110552
MESH:D006529 Hepatomegaly pirinixic acid 3.2519772884 19176532 16221962 18467677
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.8216899240
MESH:D006943 Hyperglycemia pirinixic acid 3.3820558911
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.3515338365
MESH:D007333 Insulin Resistance pirinixic acid 2.7616306350
MESH:D007674 Kidney Diseases Ethylene Dibromide 4.7612628311
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell Emodin 5.2317077332
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 2.9117157831 16943688 11903743 16221502 21278145 11408273 16239168 17174718 17334410
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 3.7517900296 17869086 18429990 15650968 15052691 12389079 17525996 14620537 18481824 12649538 16097048 18317297 12586293 15730626 18418968 16116963 15876570 17761835 17766677 14512876 17631135 12445418 18279442 18277467 18339082 18472094 18187930 12546737 15123356 11481614 12958196 14748882 17640975 14724832 12667390 16136751 17976157 17708605 18376398 15893842 17714472 17698563 17721639 15925388 18205269 12898905 15362042 17481882 18420326 12666154 18395914 17557913 12741479 17805973 15996030 15338365 16011737 12632514 18263696 17922224 10355542 18472332 16033810 17944888 14716833 20821823 12445421 16638106 18412020 18006644 12609069 15370692 18251166 16248980 18395095 18705752 16027843 18054572 16192424 17823541 12632512 18210741 15959796 14716496 18156304 15673190 13678700 15931870 15818738 15057751 18166357 17565644 16015684
MESH:D008106 Liver Cirrhosis, Experimental Emodin 3.7515288473
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 3.7515474484
MESH:D008107 Liver Diseases 1-Naphthylisothiocyanate 4.6217184895
MESH:D008107 Liver Diseases Carbon Tetrachloride 4.6217285989 16246199 15720792 15830285 16964402
MESH:D017093 Liver Failure Carbon Tetrachloride 4.4215123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 3.8814706259 16899240
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 4.6619294768
MESH:D008113 Liver Neoplasms pirinixic acid 4.6620007298 15890375 16377806
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 7.0915583823 12014681
MESH:D008114 Liver Neoplasms, Experimental glycidol 7.0912562636 12692647
MESH:D008175 Lung Neoplasms glycidol 3.7612692647 12562636
MESH:D015674 Mammary Neoplasms, Animal glycidol 6.0712562636 12692647 8818859
MESH:D008325 Mammary Neoplasms, Experimental Ethylene Dibromide 7.8911921183
MESH:D008325 Mammary Neoplasms, Experimental glycidol 7.8911921183
MESH:D009062 Mouth Neoplasms glycidol 5.5412562636
MESH:D009135 Muscular Diseases pirinixic acid 3.7616239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.2119151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.1016411023
MESH:D009369 Neoplasms pirinixic acid 2.0317405874
MESH:D009669 Nose Neoplasms Ethylene Dibromide 5.809385384
MESH:D009765 Obesity pirinixic acid 1.8520558911
MESH:D010051 Ovarian Neoplasms Mifepristone 3.1816525653
MESH:D010382 Peliosis Hepatis 1-Naphthylisothiocyanate 6.1720133375
MESH:D011470 Prostatic Hyperplasia Calcitriol 5.0615572423
MESH:D011471 Prostatic Neoplasms Calcitriol 3.5112479363 15754350 18247401 16289102 16644109
MESH:D015427 Reperfusion Injury pirinixic acid 2.4719058328
MESH:D012878 Skin Neoplasms glycidol 4.6512692647 12562636
MESH:D013274 Stomach Neoplasms Ethylene Dibromide 3.913768853
MESH:D013274 Stomach Neoplasms glycidol 3.918818859 12562636 11397402 12692647
MESH:D013921 Thrombocytopenia 1-Naphthylisothiocyanate 4.9520133375
MESH:D013964 Thyroid Neoplasms glycidol 5.1412562636
MESH:D014594 Uterine Neoplasms glycidol 5.9112692647 12562636
No data
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Syndromic Genes

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AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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