AutismKB 2.0

Annotation Detail for SLC38A11


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Basic Information Top
Gene Symbol:SLC38A11 ( AVT2,FLJ39822,MGC150450 )
Gene Full Name: solute carrier family 38, member 11
Band: 2q24.3
Quick LinksEntrez ID:151258; OMIM: NA; Uniprot ID:S38AB_HUMAN; ENSEMBL ID: ENSG00000169507; HGNC ID: 26836
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of SLC38A11 proteinaffects expression 20106945
D000638 Amiodarone Amiodarone results in increased expression of SLC38A11 mRNAincreases expression 19774075
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of SLC38A11 mRNAdecreases expression 20106945
D016572 Cyclosporine Cyclosporine results in decreased expression of SLC38A11 mRNAdecreases expression 20106945
D004958 Estradiol Estradiol results in decreased expression of SLC38A11 mRNAdecreases expression 20106945
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of SLC38A11 mRNAdecreases expression 20106945
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.3114514962 15322242 11752688
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 4.5020127859 20464547
MESH:D000230 Adenocarcinoma Estradiol 4.5011473722
MESH:D000236 Adenoma Benzo(a)pyrene 2.826695378
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.8416835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.2511748828
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.4919183758
MESH:D001145 Arrhythmias, Cardiac Amiodarone 4.1118057881 20041841 18218290
MESH:D001281 Atrial Fibrillation Amiodarone 4.1319698954 18651412
MESH:D001778 Blood Coagulation Disorders Amiodarone 10.1519483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 10.1512125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.3115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.9515746008
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 1.7917474063 20146248
MESH:D001943 Breast Neoplasms Estradiol 1.7918497071 16675129 14630087 17289903 17018787 12948864 19861407 17261762
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.7920435547
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.9316111702
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 3.0516835633
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 3.1521507988 12907637 12619106
MESH:D006528 Carcinoma, Hepatocellular Estradiol 3.1516924424
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 2.1220419170
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.5216120746 18670907 18850075
MESH:D002311 Cardiomyopathy, Dilated Amiodarone 2.9815710769 19225199
MESH:D002341 Carotid Artery Thrombosis Amiodarone 5.5518974383
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 7.2712371664
MESH:D002471 Cell Transformation, Neoplastic Estradiol 7.2718566989
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.4516835633
MESH:D002779 Cholestasis Cyclosporine 3.1419486331
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.2112621046 8697196 15668235 16354765 15340226
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.3417141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2615322242 10048152 20055451
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7217107852
MESH:D003928 Diabetic Nephropathies Estradiol 3.7019279558
MESH:D056486 Drug-Induced Liver Injury Amiodarone 4.1018218290 15265979
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 4.1020420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.9911462148
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.7012711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.4218230668 15322242 16714409
MESH:D016889 Endometrial Neoplasms Estradiol 3.1719148513 18566989 11473722
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.339294722 10568697
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 2.0716530937
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.2411564622
MESH:D005234 Fatty Liver Amiodarone 8.9414986274
MESH:D005234 Fatty Liver Cyclosporine 8.9419224547
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.8711858732
MESH:D005355 Fibrosis Cyclosporine 9.9112639820 12168785
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 9.9120067830
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.688708960
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 5.1210696789
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 6.9320471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.9310048152 11294989
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.8815720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.6611000095
MESH:D006529 Hepatomegaly Amiodarone 9.9615265979
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 9.9612621046 15340226 16120746
MESH:D006558 Herpes Genitalis Estradiol 5.5515709030
MESH:D019584 Hot Flashes Estradiol 4.2717088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.5716354765 15340226 18606429 16959395 8697196
MESH:D006937 Hypercholesterolemia Amiodarone 4.209751232 8137927
MESH:D006973 Hypertension Cyclosporine 5.2810903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.2818670907 18850075
MESH:D007037 Hypothyroidism Amiodarone 4.9317991464 18020914
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 1.9912878042 12200463
MESH:D007333 Insulin Resistance Estradiol 3.1616627594 16393666
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.6616580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.9615604871
MESH:D007674 Kidney Diseases Cyclosporine 6.4918776723 8314463 10903974
MESH:D007674 Kidney Diseases Estradiol 6.4915618244
MESH:D007680 Kidney Neoplasms Cyclosporine 8.1812371664
MESH:D007680 Kidney Neoplasms Estradiol 8.1815610895
MESH:D008064 Lipidoses Amiodarone 3.7317567588 15342952
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 2.3314659978 14716833
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.3312878042
MESH:D008113 Liver Neoplasms Aflatoxin B1 7.972125692 15890375 9163691 18177683
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 7.9720195826 21137059
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 7.9716984957
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 6.428603461
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 6.4212151625
MESH:D008133 Long QT Syndrome Amiodarone 3.8217391786 15350150 11989578
MESH:D008171 Lung Diseases Amiodarone 3.5712587719
MESH:D017563 Lung Diseases, Interstitial Amiodarone 5.0018516814
MESH:D008175 Lung Neoplasms Aflatoxin B1 3.5114755239
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 3.5120135361 20464547 6695378 18520028 18816296 20064080 18569708 20869020 17053015
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.5111884234 19555203
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 2.7416891317 17203775 11807958 11408345
MESH:D020149 Manganese Poisoning Estradiol 5.0019453300
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.3116801185
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.4316381670
MESH:D009181 Mycoses Amiodarone 5.4212754197 17974566
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.2712213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 3.5216810080
MESH:D009369 Neoplasms Benzo(a)pyrene 2.3011141357
MESH:D009389 Neovascularization, Pathologic Estradiol 4.1917289903
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.9617954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.5718481113 19348381
MESH:D009421 Nervous System Malformations Estradiol 10.7716427766 11399458
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 10.7714600291
MESH:D010051 Ovarian Neoplasms Estradiol 2.2919401270
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.7712520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.9418163543
MESH:D011230 Precancerous Conditions Cyclosporine 3.5112371664
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.6511222880 11118676 11399792 11896295
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 4.2120887781
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 3.0417292933
MESH:D011471 Prostatic Neoplasms Estradiol 3.0416740699
MESH:D011565 Psoriasis Cyclosporine 2.3116882103
MESH:D011658 Pulmonary Fibrosis Amiodarone 2.9511597910 12490602 12832656
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.2218990726
OMIM:609620 SHORT QT SYNDROME 1 Amiodarone 5.5518724381
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 5.9010029692 19755658
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.9016192470
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 1.5620155912 2093021
MESH:D013276 Stomach Ulcer Amiodarone 3.6418087811
MESH:D013610 Tachycardia Amiodarone 4.6711238279
MESH:D017180 Tachycardia, Ventricular Amiodarone 4.5719225199
MESH:D013959 Thyroid Diseases Amiodarone 13.8519731979
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 13.8512697716
MESH:D013971 Thyrotoxicosis Amiodarone 5.2818020914 19584973
MESH:D013978 Tibial Fractures Estradiol 5.2119048282
MESH:D016171 Torsades de Pointes Amiodarone 4.6517467628 11989578
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 2.2817053015
MESH:D014605 Uveitis Cyclosporine 4.501336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 5.1212125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.7715886252
MESH:D014985 Xerophthalmia Cyclosporine 4.9617120751
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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