AutismKB 2.0

Annotation Detail for CTSZ


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Basic Information Top
Gene Symbol:CTSZ ( CTSX,FLJ17088 )
Gene Full Name: cathepsin Z
Band: 20q13.32
Quick LinksEntrez ID:1522; OMIM: 603169; Uniprot ID:CATZ_HUMAN; ENSEMBL ID: ENSG00000101160; HGNC ID: 2547
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04142Lysosome
Pathway IDPathway Name
Membrane Trafficking
No data
No data
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C422565 13beta-methyl 19-nor-steroid [Progesterone co-treated with 13beta-methyl 19-nor-steroid co-treated with IFNE protein] results in increased expression of CTSZ mRNAaffects cotreatment|increases expression 16099855
D000082 Acetaminophen Acetaminophen affects the expression of CTSZ mRNAaffects expression 17562736
C057862 cyanoginosin LR cyanoginosin LR results in increased expression of CTSZ mRNAincreases expression 17654400
C014347 decitabine decitabine affects the expression of CTSZ mRNAaffects expression 17194187
C014347 decitabine [decitabine co-treated with vorinostat] affects the expression of CTSZ mRNAaffects cotreatment|affects expression 17330099
D004041 Dietary Fats Dietary Fats results in decreased expression of CTSZ mRNAdecreases expression 18042831
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CTSZ mRNAaffects cotreatment|increases expression 17942748
C011890 kojic acid kojic acid results in increased expression of CTSZ mRNAincreases expression 16595896
C041786 palm oil palm oil results in decreased expression of CTSZ mRNAdecreases expression 18042831
D011374 Progesterone IFNE protein promotes the reaction [Progesterone results in increased expression of CTSZ mRNA]increases expression|increases reaction 16099855
D011374 Progesterone [Progesterone co-treated with 13beta-methyl 19-nor-steroid co-treated with IFNE protein] results in increased expression of CTSZ mRNAaffects cotreatment|increases expression 16099855
D011374 Progesterone Progesterone results in increased expression of CTSZ mRNAincreases expression 16099855
D017632 Asbestos, Serpentine Asbestos, Serpentine results in increased expression of CTSZ mRNAincreases expression 16251409
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CTSZ mRNAaffects cotreatment|increases expression 17942748
C111237 vorinostat [decitabine co-treated with vorinostat] affects the expression of CTSZ mRNAaffects cotreatment|affects expression 17330099
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.0011752688 15322242 14514962
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.1217505938
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.8314692618
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.5316835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.0511748828
MESH:D000799 Angioedema Acetaminophen 4.0210982225
MESH:D001161 Arteriosclerosis Dietary Fats 10.3815238619
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 10.3811256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.7315885639
MESH:D001195 Asbestosis Asbestos, Serpentine 5.8010751356
MESH:D001321 Autistic Disorder Acetaminophen 1.4118445737
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.1512125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.9615340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8315746008
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 5.5117868700
MESH:D001930 Brain Injuries Progesterone 4.4015845082 15380490 15665606
MESH:D001943 Breast Neoplasms decitabine 2.3918320071 19208741
MESH:D001943 Breast Neoplasms Dietary Fats 2.3920435547
MESH:D001943 Breast Neoplasms Progesterone 2.3915562024 17614352 16175315
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.3920435547
MESH:D001943 Breast Neoplasms vorinostat 2.3916144943
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.8916835633
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 1.383084413
MESH:D002294 Carcinoma, Squamous Cell decitabine 2.6219215824
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4218670907 16120746 18850075
MESH:D002386 Cataract Acetaminophen 2.6410977129
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.2616835633
MESH:D002779 Cholestasis Ethinyl Estradiol 2.9517333356 17681005 15861022 16105132 17110522 16919318 11677210
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.148697196 12621046 15340226 16354765 15668235
MESH:D003110 Colonic Neoplasms decitabine 2.3517616700
MESH:D015179 Colorectal Neoplasms decitabine 2.1018981723
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.1617141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2615322242 10048152 20055451
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6917107852
MESH:D003929 Diabetic Neuropathies Progesterone 4.6317187935
MESH:D003967 Diarrhea vorinostat 4.6220479100
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 6.4511461765 19923254 18713872 11421492 14725611 17522070 16177239 12958197 11743745 12594235 17906064 16485898 10915739 19164858 16081117 2444490 16781746 11834606 14986274 19370779 11287661 16227642 16109766 16393943 19739265 17562736 15968718 10774834 18071297 14550746 11739529 15619225 19085960 12153990 19416960 12392966 12705907 12540782 11529661 19420014 10663392
MESH:D056486 Drug-Induced Liver Injury cyanoginosin LR 6.4517654400
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 6.4520420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.2719426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8411462148
MESH:D050171 Dyslipidemias Dietary Fats 3.5318367378
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.4811000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.0818230668 15322242 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 9.4612538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 9.4617692515
MESH:D004701 Endocrine Gland Neoplasms decitabine 5.2919294695
MESH:D004715 Endometriosis Progesterone 9.2816134523
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 9.2810568697 9294722
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.0911564622
MESH:D005221 Fatigue vorinostat 5.7520479100
MESH:D005234 Fatty Liver Dietary Fats 8.0918296743 17967931 19004024 19551842
MESH:D005234 Fatty Liver Ethinyl Estradiol 8.0915345470
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.5911858732
MESH:D005355 Fibrosis Dietary Fats 9.0918296743
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 9.0920067830
MESH:D005756 Gastritis Acetaminophen 3.8516983495
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.7710696789
MESH:D006258 Head and Neck Neoplasms decitabine 3.5619215824
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.3811294989 10048152
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.4411000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.0315340226 16120746 12621046
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.228697196 16959395 15340226 18606429 16354765
MESH:D006930 Hyperalgesia Acetaminophen 2.7916870215
MESH:D006937 Hypercholesterolemia Dietary Fats 3.7021332399
MESH:D006949 Hyperlipidemias Dietary Fats 3.7321332399
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9418850075 18670907
MESH:D007021 Hypospadias Ethinyl Estradiol 3.9516945680 16569931
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 4.5415869954
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.5812013081
MESH:D007248 Infertility, Male decitabine 6.9617581917
MESH:D007248 Infertility, Male Ethinyl Estradiol 6.9617937319
MESH:D007249 Inflammation Dietary Fats 8.6320412841
MESH:D007249 Inflammation Progesterone 8.6315869954
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 8.6312200463 12878042
MESH:D007333 Insulin Resistance Dietary Fats 3.1718457598 11836018
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.4416580747
MESH:D007674 Kidney Diseases Acetaminophen 2.2615629191 12587719
MESH:D007938 Leukemia decitabine 3.1219235587 18980019
MESH:D007951 Leukemia, Myeloid decitabine 4.1119117987 17236224 18454857
MESH:D015470 Leukemia, Myeloid, Acute marker/mechanism 17330099
MESH:D015470 Leukemia, Myeloid, Acute decitabine 2.3919010910 18704418 18460780 19387464 17679729 18206229
MESH:D015477 Leukemia, Myelomonocytic, Chronic decitabine 5.6418055864
MESH:D008103 Liver Cirrhosis Dietary Fats 2.9318296743
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 1.2412878042
MESH:D008107 Liver Diseases Acetaminophen 1.6519784758 12587719 19460945 11587558 19014921 16611625 16610002 12969438
MESH:D017114 Liver Failure, Acute Acetaminophen 3.3417185352 16871587
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 1.7516984957
MESH:D008114 Liver Neoplasms, Experimental kojic acid 6.2418544905
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 6.2412151625
MESH:D008171 Lung Diseases Asbestos, Serpentine 4.4217200189
MESH:D008175 Lung Neoplasms Asbestos, Serpentine 2.7611198217
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 2.7611884234 19555203
MESH:D008223 Lymphoma decitabine 3.4919470736
MESH:D016410 Lymphoma, T-Cell, Cutaneous vorinostat 5.8220479100
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 2.9317203775 11408345
MESH:D008545 Melanoma decitabine 2.2616505122 17785578
MESH:D008546 Melanoma, Experimental Acetaminophen 3.7119513568
MESH:D009101 Multiple Myeloma decitabine 3.4218172295
MESH:D009190 Myelodysplastic Syndromes decitabine 3.4419010910 16882708 19157545 18608210
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.1112213967
MESH:D009325 Nausea vorinostat 5.7020479100
MESH:D009369 Neoplasms decitabine 2.7619470736 19116145 17925555
MESH:D009374 Neoplasms, Experimental Asbestos, Serpentine 4.9811704859
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.3414600291
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.9618514411
MESH:D009765 Obesity Dietary Fats 2.3120132043 17217161 20518802 21332399 18457598 11836018 19632207 18674790 16723640
MESH:D010051 Ovarian Neoplasms decitabine 5.1319259094 19331143
MESH:D010051 Ovarian Neoplasms Progesterone 5.1317393432 16525653
MESH:D010146 Pain Acetaminophen 2.4816870215
MESH:D010190 Pancreatic Neoplasms decitabine 2.8019294695
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.8011578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.4212520081
MESH:D010995 Pleural Diseases Asbestos, Serpentine 5.8310923243
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.6918163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.3411399792 11118676 11896295 11222880
MESH:D055728 Primary Myelofibrosis decitabine 4.8717616702
MESH:D011471 Prostatic Neoplasms vorinostat 4.4517218635
MESH:D011537 Pruritus Ethinyl Estradiol 3.4715861022 16919318
MESH:D011658 Pulmonary Fibrosis Asbestos, Serpentine 3.8618569384 15511213
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.9618990726
MESH:D012208 Rhabdomyosarcoma decitabine 4.5219155313
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.8918045962
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.0916192470
MESH:D013088 Spermatocele Ethinyl Estradiol 4.1216709447
MESH:D013119 Spinal Cord Injuries Progesterone 4.4315862959 16503802
MESH:D013274 Stomach Neoplasms decitabine 2.1019037991
MESH:D013921 Thrombocytopenia vorinostat 5.0720479100
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.7411994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.2515669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.0812697716
MESH:D013964 Thyroid Neoplasms decitabine 3.4117967635
MESH:D014376 Tuberculosis marker/mechanism
MESH:D001749 Urinary Bladder Neoplasms decitabine 2.7617616700 19087683
MESH:D014581 Urticaria Acetaminophen 3.0910982225
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.4214692618
MESH:D014604 Uveal Neoplasms decitabine 5.0917785578
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.7712125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.6514671159 15869587
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.4215886252
MESH:D015430 Weight Gain Dietary Fats 3.8316723640
Pathway ID Pathway Name
KEGG:04142 Lysosome
REACT:11123 Membrane Trafficking
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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