AutismKB 2.0

Annotation Detail for FGD5


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Basic Information Top
Gene Symbol:FGD5 ( ZFYVE23 )
Gene Full Name: FYVE, RhoGEF and PH domain containing 5
Band: 3p25.1
Quick LinksEntrez ID:152273; OMIM: NA; Uniprot ID:FGD5_HUMAN; ENSEMBL ID: ENSG00000154783; HGNC ID: 19117
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in increased expression of FGD5 mRNAincreases expression 18648102
D000638 Amiodarone Amiodarone results in increased expression of FGD5 mRNAincreases expression 19774075
C025643 vinclozolin vinclozolin affects the expression of FGD5 mRNAaffects expression 19015723
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 2.983712494
MESH:D001008 Anxiety Disorders vinclozolin 4.0019015723
MESH:D001145 Arrhythmias, Cardiac Amiodarone 4.2520041841 18218290 18057881
MESH:D001281 Atrial Fibrillation Amiodarone 4.2318651412 19698954
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.8911289319 1440618
MESH:D001778 Blood Coagulation Disorders Amiodarone 4.3819483382
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 1.787296757 3581430
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.847296757
MESH:D002311 Cardiomyopathy, Dilated Amiodarone 3.0119225199 15710769
MESH:D002341 Carotid Artery Thrombosis Amiodarone 5.8318974383
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 3.057505956
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 3.4719486331 9022650
MESH:D003456 Cryptorchidism vinclozolin 4.9314966744
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 3.442524372 18759878 11298694 8156756 14531868 12868966 8970840 11906362
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 4.022952479 3621924
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 4.3418289764 9328219 18692083 7440962 1440618 16192314 6482804 9022650 18648102 11289319 6679447 8291058 9653073
MESH:D056486 Drug-Induced Liver Injury Amiodarone 4.3415265979 18218290
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 2.193581430
MESH:D005234 Fatty Liver Amiodarone 4.0014986274
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.896705139
MESH:D030342 Genetic Diseases, Inborn vinclozolin 5.6816973722
MESH:D005832 Genital Diseases, Male vinclozolin 6.1716417039
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.577505956
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 4.106705139
MESH:D006529 Hepatomegaly Amiodarone 4.4015265979
MESH:D006937 Hypercholesterolemia Amiodarone 4.368137927 9751232
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.5915034207
MESH:D007037 Hypothyroidism Amiodarone 5.1717991464 18020914
MESH:D007248 Infertility, Male vinclozolin 3.3216467254
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.898074119 9022650
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 3.356582329
MESH:D007984 Leydig Cell Tumor vinclozolin 5.4716417039
MESH:D008064 Lipidoses Amiodarone 3.8215342952 17567588
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.4415034207 9327722
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 2.78598648 3712494 6587162 1399818
MESH:D008133 Long QT Syndrome Amiodarone 3.9215350150 11989578 17391786
MESH:D008171 Lung Diseases Amiodarone 3.6512587719
MESH:D017563 Lung Diseases, Interstitial Amiodarone 5.3418516814
MESH:D009181 Mycoses Amiodarone 5.7717974566 12754197
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 2.613581430
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 3.186679447
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 3.876482804 4026338
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.893988306
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 4.137296757
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 5.346228378
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 4.6419015723 18220299 18042343
MESH:D011469 Prostatic Diseases vinclozolin 5.6818220299
MESH:D011472 Prostatitis vinclozolin 5.6818629315
MESH:D011658 Pulmonary Fibrosis Amiodarone 2.9812832656 12490602 11597910
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.703692021
OMIM:609620 SHORT QT SYNDROME 1 Amiodarone 5.8318724381
MESH:D013276 Stomach Ulcer Amiodarone 3.7918087811
MESH:D013610 Tachycardia Amiodarone 4.8711238279
MESH:D017180 Tachycardia, Ventricular Amiodarone 4.7719225199
MESH:D013959 Thyroid Diseases Amiodarone 5.6219731979
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 3.221399818 6587162 3712494 7505956 6582329
MESH:D013971 Thyrotoxicosis Amiodarone 5.5118020914 19584973
MESH:D016171 Torsades de Pointes Amiodarone 4.9311989578 17467628
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 2.418074119
No data
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA134874843
    • No data
    Releated disease ID Related disease Name
    PA446847Arrhythmogenic Right Ventricular Dysplasia
    No data
    Drug Bank Top

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    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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