AutismKB 2.0

Annotation Detail for CUX1


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Basic Information Top
Gene Symbol:CUX1 ( CASP,CDP,CDP/Cut,CDP1,COY1,CUTL1,CUX,Clox,Cux/CDP,GOLIM6,Nbla10317,p100,p110,p200,p75 )
Gene Full Name: cut-like homeobox 1
Band: 7q22.1
Quick LinksEntrez ID:1523; OMIM: 116896; Uniprot ID:CASP_HUMAN; ENSEMBL ID: ENSG00000160967; HGNC ID: 2557
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1766Renal Cell cancer
1770Melanoma
2227Uterine fibroids
No data
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C027576 4-hydroxy-2-nonenal 4-hydroxy-2-nonenal results in decreased expression of CUX1 mRNAdecreases expression 12419474
D000643 Ammonium Chloride Ammonium Chloride affects the expression of CUX1 mRNAaffects expression 16483693
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of CUX1 mRNAdecreases expression 20064835
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of CUX1 mRNAdecreases expression 20018196
C005961 bis(tri-n-butyltin)oxide bis(tri-n-butyltin)oxide results in increased expression of CUX1 mRNAincreases expression 17553608
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in decreased expression of CUX1 mRNAdecreases expression 12419474
D002251 Carbon Tetrachloride Carbon Tetrachloride results in increased expression of CUX1 mRNAincreases expression 17484886
D019833 Genistein Genistein results in increased expression of CUX1 mRNAincreases expression 15256057
D006861 Hydrogen Peroxide Hydrogen Peroxide results in decreased expression of CUX1 mRNAdecreases expression 12419474
D009151 Mustard Gas Mustard Gas results in increased expression of CUX1 mRNAincreases expression 15674843
C006253 pirinixic acid pirinixic acid results in increased expression of CUX1 mRNAincreases expression 18301758
D013629 Tamoxifen Tamoxifen results in decreased expression of CUX1 mRNAdecreases expression 17555576
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with AHR gene mutant form] results in decreased expression of CUX1 mRNAaffects cotreatment|decreases expression 19465110
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.6814745880
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.9615322242 14514962 11752688
MESH:D000138 Acidosis Ammonium Chloride 3.6818287403
MESH:D055371 Acute Lung Injury pirinixic acid 3.2018653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 4.4820464547 20127859
MESH:D000230 Adenocarcinoma Genistein 4.4811473722
MESH:D000236 Adenoma Benzo(a)pyrene 2.706695378
MESH:D018248 Adenoma, Liver Cell pirinixic acid 10.3016434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 10.3016835633
MESH:D000690 Amyotrophic Lateral Sclerosis 4-hydroxy-2-nonenal 4.1510965797
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.0211748828
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.1819183758
MESH:D001249 Asthma Mustard Gas 2.7310378619
MESH:D001768 Blister Mustard Gas 5.2819167455
MESH:D001778 Blood Coagulation Disorders pirinixic acid 9.0419483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 9.0412125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.9215340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8115746008
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 1.9417474063 20146248
MESH:D001943 Breast Neoplasms Genistein 1.9416873071 16541309 17200150
MESH:D001943 Breast Neoplasms Tamoxifen 1.9421138602 19142967 19289846 18629630 21152245 19244106 19487384 19066611 19410462 19221464 17049068 20135344 19103187 17242785 20005174 18815881 18997820 18855134 20390343 19084267 18821012 19155303 18425577 18351453 18984771 11161223 19288272 16818667 20065188 19189210 17261762 19059307 20859285 16202921 20544844 17893378 19200415 19189212 19115204 19011961 17440819 16273361 15668708 16873071 15565566
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9420435547
MESH:D001989 Bronchiolitis Obliterans Mustard Gas 5.2815286001
MESH:D029481 Bronchitis, Chronic Mustard Gas 5.1117687719 10378619
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.8815721981 16192424 18705752 16050911 15700767 3786805 15673190 16124888 16227642 16097048 16011737 10355542
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.8616835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.6119066611
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 4.7018788625
MESH:D006528 Carcinoma, Hepatocellular Genistein 4.7016924424
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 4.7016924424
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 2.0720419170
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.6917572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4118670907 16120746 18850075
MESH:D002318 Cardiovascular Diseases Genistein 7.7116332659
MESH:D002318 Cardiovascular Diseases Hydrogen Peroxide 7.7116936243
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.7820889678
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.2316835633
MESH:D002779 Cholestasis pirinixic acid 2.8819176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1316354765 15668235 12621046 15340226 8697196
MESH:D003110 Colonic Neoplasms Genistein 2.3017182828
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.1317141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2615322242 20055451 10048152
MESH:D003711 Demyelinating Diseases Tamoxifen 4.4719031437
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4618249437
MESH:D003924 Diabetes Mellitus, Type 2 Genistein 4.3916647724
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.3917107852
MESH:D003928 Diabetic Nephropathies Tamoxifen 3.5519279558
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 3.793732212 21278145 3786805 2869522 19336974 10915739 7120509 10092053 6623471 6884620 7440962 7179309 19085960 17522070 15998439 15027814 15968718 16227642 11566570 4309450 16177239 9327722
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 3.7920420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8211462148
MESH:D004487 Edema Mustard Gas 11.9111428631 11428647 11402378 9260866
MESH:D004487 Edema pirinixic acid 11.9112083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 11.9111000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.0418230668 15322242 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 3.6319031437
MESH:D004714 Endometrial Hyperplasia Genistein 4.7116402032
MESH:D016889 Endometrial Neoplasms Genistein 7.7011473722
MESH:D016889 Endometrial Neoplasms Tamoxifen 7.7017893378 20544844 19155303 16202921
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.109294722 10568697
MESH:D004890 Erythema Mustard Gas 5.289357497
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 4.4120426865
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.4116530937
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.0711564622
MESH:D005234 Fatty Liver Carbon Tetrachloride 13.5715959796 16045604 12795759 16239168 12631006 17595544 19224547 61145
MESH:D005234 Fatty Liver pirinixic acid 13.5719236843 20131406
MESH:D005234 Fatty Liver Tamoxifen 13.5719224547 14986274
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.2816709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.5611858732
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.6414745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.3019069698
MESH:D005355 Fibrosis Carbon Tetrachloride 8.9518705752
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 8.9520067830
MESH:D005909 Glioblastoma Genistein 3.3116598420
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.7310696789
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 6.5820471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.5811294989 10048152
MESH:D006333 Heart Failure pirinixic acid 2.5820558911
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.4211000095
MESH:D006505 Hepatitis Carbon Tetrachloride 3.6919110552 19900420
MESH:D006529 Hepatomegaly pirinixic acid 8.6116221962 19176532 18467677 19772884
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 8.6112621046 16120746 15340226
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.1818606429 8697196 16959395 15340226 16354765
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.6516899240
MESH:D006943 Hyperglycemia pirinixic acid 3.2620558911
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9318850075 18670907
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.1915338365
MESH:D007249 Inflammation Mustard Gas 8.5611402378 9260866 11428647 8975870 11428631 9357497 11428620 17524151 16001271
MESH:D007249 Inflammation Tamoxifen 8.5619457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 8.5612878042 12200463
MESH:D007333 Insulin Resistance pirinixic acid 2.6816306350
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.4216580747
MESH:D007676 Kidney Failure, Chronic Hydrogen Peroxide 4.3516518626
MESH:D007680 Kidney Neoplasms Tamoxifen 3.1118625569
MESH:D007938 Leukemia Genistein 3.0617468513 18980019
MESH:D008064 Lipidoses Tamoxifen 3.2115342952 17567588
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 2.8517157831 11408273 16239168 16943688 11903743 17334410 16221502 21278145 17174718
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 6.8317805973 12898905 18205269 14620537 15338365 18006644 16027843 15818738 15673190 17557913 12632514 17761835 18210741 15925388 18418968 18472332 15730626 17698563 15876570 12389079 12667390 16136751 18156304 12666154 16248980 17823541 18429990 17708605 12445421 14512876 17640975 15370692 13678700 18412020 17525996 12546737 16097048 14716496 18481824 17714472 15893842 14748882 12958196 12649538 16192424 18251166 17766677 18376398 18705752 18395914 20821823 17481882 12632512 12445418 15959796 16015684 18263696 18054572 18420326 17869086 12609069 15057751 17900296 15996030 15650968 16011737 15123356 17631135 12741479 18339082 14724832 18279442 14716833 17565644 16033810 18187930 17721639 15362042 15931870 12586293 18395095 16638106 18277467 18317297 17922224 11481614 17944888 10355542 17976157 18166357 15052691 18472094 16116963
MESH:D008106 Liver Cirrhosis, Experimental Genistein 6.8317823541
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 6.8315474484
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 6.8318564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 6.8312878042
MESH:D008107 Liver Diseases Carbon Tetrachloride 2.1015830285 16964402 16246199 15720792 17285989
MESH:D017093 Liver Failure Carbon Tetrachloride 4.2715123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 3.7714706259 16899240
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 14.5420195826 21137059
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 14.5419294768
MESH:D008113 Liver Neoplasms pirinixic acid 14.5416377806 20007298 15890375
MESH:D008113 Liver Neoplasms Tamoxifen 14.5416684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 14.5416984957
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 5.9212014681 15583823
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 5.9212151625
MESH:D008171 Lung Diseases Mustard Gas 3.5018161513 18702808
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 4.9120464547 6695378 17053015 18816296 18520028 20064080 20135361 18569708 20869020
MESH:D008175 Lung Neoplasms Mustard Gas 4.918781369 3148597
MESH:D008175 Lung Neoplasms Tamoxifen 4.9118625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 4.9119555203 11884234
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 3.8819428831
MESH:D008325 Mammary Neoplasms, Experimental Genistein 6.2814578162 12929590
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 6.2819196723 14580682 16827153 19196722 11731420
MESH:D020149 Manganese Poisoning Tamoxifen 4.6819453300
MESH:D008545 Melanoma Tamoxifen 1.8919393235 12393984
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.3015990972
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.2516381670
MESH:D009135 Muscular Diseases pirinixic acid 3.6116239165
MESH:D009203 Myocardial Infarction Genistein 5.7817141266
MESH:D009203 Myocardial Infarction pirinixic acid 5.7819151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.0812213967
MESH:D015428 Myocardial Reperfusion Injury Genistein 8.6017141266
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 8.6016411023
MESH:D009362 Neoplasm Metastasis Tamoxifen 2.5719393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.5419410462
MESH:D009369 Neoplasms Benzo(a)pyrene 4.9511141357
MESH:D009369 Neoplasms pirinixic acid 4.9517405874
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 4.1319200415 19196722 19189210
MESH:D009421 Nervous System Malformations Genistein 9.9216427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 9.9214600291
MESH:D009503 Neutropenia Mustard Gas 4.067688884 16761898
MESH:D009765 Obesity pirinixic acid 1.8320558911
MESH:D010024 Osteoporosis Genistein 3.3019401787
MESH:D015663 Osteoporosis, Postmenopausal Genistein 4.1716169203
MESH:D010051 Ovarian Neoplasms Genistein 2.6219005980
MESH:D010212 Papilloma Hydrogen Peroxide 4.1912065085
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.3812520081
MESH:D010787 Photosensitivity Disorders 4-hydroxy-2-nonenal 5.6411550810
MESH:D011041 Poisoning Mustard Gas 3.8815727166
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.6518163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.3111896295 11399792 11118676 11222880
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.5417292933
MESH:D011471 Prostatic Neoplasms Genistein 2.5415256057 16925846 15378649
MESH:D011471 Prostatic Neoplasms Tamoxifen 2.5415067354
MESH:D011537 Pruritus Mustard Gas 4.2118058305
MESH:D011658 Pulmonary Fibrosis Mustard Gas 2.9517720292 17894541 10334151 17266442 17620002
MESH:D015427 Reperfusion Injury pirinixic acid 2.4219058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.9318990726
MESH:D012871 Skin Diseases Mustard Gas 2.7312880345 15451306 16961503
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 13.8719755658 10029692
MESH:D012878 Skin Neoplasms Hydrogen Peroxide 13.8712065085
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 13.878532709
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 13.8716192470
MESH:D013088 Spermatocele Tamoxifen 4.4316709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 4.1519457130
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 1.5620155912 2093021
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.0412697716
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 5.0917053015
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 5.0916712894 17572228 8653321
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.7312125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.3815886252
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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