AutismKB 2.0

Annotation Detail for CX3CR1


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:CX3CR1 ( CCRL1,CMKBRL1,CMKDR1,GPR13,GPRV28,V28 )
Gene Full Name: chemokine (C-X3-C motif) receptor 1
Band: 3p22.2
Quick LinksEntrez ID:1524; OMIM: 601470; Uniprot ID:CX3C1_HUMAN; ENSEMBL ID: ENSG00000168329; HGNC ID: 2558
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04062Chemokine signaling pathway
hsa04060Cytokine-cytokine receptor interaction
Pathway IDPathway Name
Signaling by GPCR
No data
Pathway IDPathway Name
P00031Inflammation mediated by chemokine and cytokine signaling pathway
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1724Vascular disease
1781Rheumatoid arthritis
1821Spinal cord disease
1831Prostate cancer
1840Macular degeneration
1877Multiple sclerosis
1918Atherosclerosis
1954Stroke
1997Dental plaque
1998Enteritis
2017Atopic rhinitis
2022Liver cancer
1764Purpura, Thrombocytopenic, Idiopathic
2032Kidney disease
2053Colon cancer
2074Asthma
2100Hepatitis C
2111Systemic infection
2188Bone marrow disease
2205Uveitis
2220Dermatitis
2239Lymphoma
2248Cytomegalovirus infection
2256Aortic aneurysm
Desease Name
Acute Coronary Syndrome
cardiovascular disease
restenosis
Atherosclerosis
atherosclerosis, coronary
CARDIOVASCULAR
Coronary Artery Disease
Human Renal Transplantation
CANCER
coronary artery disease, occlusive
Intestinal Obstruction
RENAL
Glioblastoma
IMMUNE
retinal vascular occlusion
coronary vascular endothelial dysfunction
VISION
HIV
pulmonary arterial hypertension sclerosis, systemic
cerebrovascular disease
INFECTION
intima-media thickness
Crohn Disease
respiratory syncytial virus
No data
Desease Name
Coronary artery disease, resistance to
Macular degeneration, age-related, susceptibility to
Rapid progression to AIDS from HIV1 infection
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000643 Ammonium Chloride Ammonium Chloride affects the expression of CX3CR1 mRNAaffects expression 16483693
D002794 Choline Choline affects the expression of CX3CR1 mRNAaffects expression 17616785
D003520 Cyclophosphamide Cyclophosphamide results in increased expression of CX3CR1 proteinincreases expression 16651033
D010972 Platelet Activating Factor Platelet Activating Factor results in increased expression of CX3CR1 mRNAincreases expression 16386258
C025299 polyphenols polyphenols results in decreased expression of CX3CR1 mRNAdecreases expression 16293270
D018038 Sodium Selenite Sodium Selenite results in decreased expression of CX3CR1 mRNAdecreases expression 18175754
C066075 vanadium pentoxide vanadium pentoxide results in increased expression of CX3CR1 mRNAincreases expression 17459161
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 3.9518287403
MESH:D000741 Anemia, Aplastic marker/mechanism 18575777
MESH:D001161 Arteriosclerosis Cyclophosphamide 4.9615014928
MESH:D001321 Autistic Disorder Choline 3.3316818868
MESH:D001943 Breast Neoplasms Cyclophosphamide 2.9617020986 11325840 15136595 17388661 16978400 18323546 15093573 18234424 12006526
MESH:D001991 Bronchitis vanadium pentoxide 6.6817459161
MESH:D006528 Carcinoma, Hepatocellular Cyclophosphamide 2.6319701751
MESH:D018827 Carcinoma, Lewis Lung Cyclophosphamide 5.2816152834
MESH:D002292 Carcinoma, Renal Cell Cyclophosphamide 3.6516201981
MESH:D054506 Chloracne marker/mechanism 17101203
MESH:D019457 Chromosome Breakage Sodium Selenite 5.1115894690
MESH:D003110 Colonic Neoplasms polyphenols 2.7116293270
MESH:D003327 Coronary Disease marker/mechanism
MESH:D003556 Cystitis Cyclophosphamide 5.4318483878 16614059 18372110 15276878 17979934 10498854 16413132 18093676 10700343 15643279 12388444 12161096 11948286 18710439 16989017 16651033 18295254 12913760 17010015 18433785
MESH:D002658 Developmental Disabilities Choline 4.8516818868
MESH:D003920 Diabetes Mellitus Sodium Selenite 4.0316285004
MESH:D003921 Diabetes Mellitus, Experimental Cyclophosphamide 4.3015331540 10990075 11751995
MESH:D003922 Diabetes Mellitus, Type 1 Cyclophosphamide 3.2918772604
MESH:D056486 Drug-Induced Liver Injury polyphenols 4.4819370779
MESH:D056486 Drug-Induced Liver Injury Sodium Selenite 4.4815131321
MESH:D004802 Eosinophilia Cyclophosphamide 4.5711006010
MESH:D018316 Gliosarcoma Cyclophosphamide 5.9111389073
MESH:D006086 Graft vs Host Disease Cyclophosphamide 5.3916376943 15172196 11014644
MESH:D006467 Hemophilia A Cyclophosphamide 5.6511918545
MESH:D006504 Hepatic Veno-Occlusive Disease Cyclophosphamide 5.9814986274
MESH:D006689 Hodgkin Disease Cyclophosphamide 4.0316135485 17606976
OMIM:609423 HUMAN IMMUNODEFICIENCY VIRUS TYPE 1, SUSCEPTIBILITY TO marker/mechanism
MESH:D007154 Immune System Diseases Cyclophosphamide 5.7716076520
MESH:D007248 Infertility, Male Cyclophosphamide 3.797193160 16517039
MESH:D007249 Inflammation polyphenols 3.1816366677
MESH:D007333 Insulin Resistance Sodium Selenite 3.4514714311
MESH:D007938 Leukemia Cyclophosphamide 3.6110602166
MESH:D015451 Leukemia, Lymphocytic, Chronic, B-Cell Cyclophosphamide 3.5917296974 17658394 18587576 17802794 17008537 18172266
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive Cyclophosphamide 4.2910373061
MESH:D007970 Leukopenia Cyclophosphamide 5.3610052129 11830472
MESH:D008107 Liver Diseases polyphenols 2.8316698588
MESH:D008175 Lung Neoplasms vanadium pentoxide 3.2312376484
MESH:D008223 Lymphoma Cyclophosphamide 4.0312854902
MESH:D016393 Lymphoma, B-Cell Cyclophosphamide 11.4216675587
MESH:D016393 Lymphoma, B-Cell Sodium Selenite 11.4214737004
MESH:D008228 Lymphoma, Non-Hodgkin Cyclophosphamide 4.4011911406
MESH:D008268 Macular Degeneration marker/mechanism
MESH:D008546 Melanoma, Experimental Cyclophosphamide 5.1616388313
MESH:D009369 Neoplasms Cyclophosphamide 3.2418854779
MESH:D009447 Neuroblastoma Cyclophosphamide 3.7615176712 16115947 8761367
MESH:D017599 Neuroectodermal Tumors Cyclophosphamide 5.2812837982 8761367
MESH:D009503 Neutropenia Cyclophosphamide 4.638291058
MESH:D009845 Oligospermia Cyclophosphamide 5.1116517039
MESH:D010146 Pain Cyclophosphamide 3.8512161096 18093676
MESH:D010190 Pancreatic Neoplasms Cyclophosphamide 3.2611332152
MESH:D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma Cyclophosphamide 3.9421297632
MESH:D011471 Prostatic Neoplasms Cyclophosphamide 3.5117136230
MESH:D011471 Prostatic Neoplasms Sodium Selenite 3.5118760546
MESH:D011658 Pulmonary Fibrosis Cyclophosphamide 3.3716636934
MESH:D012595 Scleroderma, Systemic Cyclophosphamide 5.1316636934
OMIM:102530 SPERMATOGENIC FAILURE 6 Cyclophosphamide 5.9116517039
MESH:D015173 Supratentorial Neoplasms Cyclophosphamide 5.4512837982
MESH:D013705 Temporomandibular Joint Disorders polyphenols 5.6917997062
MESH:D001749 Urinary Bladder Neoplasms Cyclophosphamide 3.2314692829
Pathway ID Pathway Name
KEGG:04062 Chemokine signaling pathway
KEGG:04060 Cytokine-cytokine receptor interaction
REACT:14797 Signaling by GPCR
Pharmacogenomics Knowledge Base Top
Drug Bank Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved