AutismKB 2.0

Annotation Detail for KLB


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Basic Information Top
Gene Symbol:KLB ( BKL,MGC142213 )
Gene Full Name: klotho beta
Band: 4p14
Quick LinksEntrez ID:152831; OMIM: 611135; Uniprot ID:KLOTB_HUMAN; ENSEMBL ID: ENSG00000134962; HGNC ID: 15527
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
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Pathway IDPathway Name
200189FGF signaling pathway
No data
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Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of KLB mRNAaffects expression 17562736
D004041 Dietary Fats Dietary Fats results in decreased expression of KLB mRNAdecreases expression 18042831
C029938 nickel sulfate nickel sulfate results in decreased expression of KLB mRNAdecreases expression 16100012
C041786 palm oil palm oil results in decreased expression of KLB mRNAdecreases expression 18042831
C006253 pirinixic acid pirinixic acid results in increased expression of KLB mRNAincreases expression 18301758
D014635 Valproic Acid Valproic Acid results in increased expression of KLB mRNAincreases expression 19101580
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 3.958875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 4.2519490988
MESH:D055371 Acute Lung Injury nickel sulfate 10.3411954676 12718980 19131640 16100012
MESH:D055371 Acute Lung Injury pirinixic acid 10.3418653653
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.9416434500
MESH:D000550 Amblyopia Valproic Acid 5.7517688650
MESH:D000799 Angioedema Acetaminophen 4.3610982225
MESH:D001008 Anxiety Disorders Valproic Acid 3.8317497229
MESH:D001161 Arteriosclerosis Dietary Fats 4.3115238619
MESH:D001321 Autistic Disorder Acetaminophen 1.8618445737
MESH:D001321 Autistic Disorder Valproic Acid 1.8620603192 19232924 15238991 18940202 18316065 19460635 18558336 17688650 17507914 18396377 18985861 17157402 18177632 18775368 16609825
MESH:D001714 Bipolar Disorder Valproic Acid 3.2117594078 20046352
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.4719483382
MESH:D001848 Bone Diseases, Developmental Valproic Acid 3.598888407
MESH:D001943 Breast Neoplasms Dietary Fats 2.2520435547
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 1.403084413
MESH:D002386 Cataract Acetaminophen 2.7510977129
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.8020734317
MESH:D002779 Cholestasis pirinixic acid 3.0519176532
MESH:D019465 Craniofacial Abnormalities Valproic Acid 1.908888407 17688650 16575769
MESH:D017449 Dermatitis, Allergic Contact nickel sulfate 4.0816780908 11298694 16823706
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5518249437
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 4.0419164858 19085960 14550746 15968718 19420014 14725611 11743745 16177239 10774834 18071297 2444490 16781746 19923254 17906064 12958197 12705907 15619225 11461765 16393943 17522070 12540782 11421492 12392966 10915739 18713872 19416960 12153990 11287661 19370779 19739265 16485898 14986274 11739529 16109766 10663392 16227642 12594235 16081117 17562736 11834606 11529661
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 4.041733752 19641884
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.6219426721
MESH:D050171 Dyslipidemias Dietary Fats 3.6718367378
MESH:D004421 Dystonia Valproic Acid 4.401851702
MESH:D004487 Edema pirinixic acid 2.8012083418
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 4.573659116 17275665
MESH:D004828 Epilepsies, Partial Valproic Acid 4.4416628512 3922381
MESH:D004827 Epilepsy Valproic Acid 3.0718234410 20417680
MESH:D004832 Epilepsy, Absence Valproic Acid 3.876254150 6426943 7562514
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 4.717750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 4.533659116
MESH:D005234 Fatty Liver Dietary Fats 15.0918296743 17967931 19551842 19004024
MESH:D005234 Fatty Liver pirinixic acid 15.0919236843 20131406
MESH:D005234 Fatty Liver Valproic Acid 15.0914986274 19224547
MESH:D005315 Fetal Diseases Valproic Acid 5.4116575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 4.518888407 18558336
MESH:D005355 Fibrosis Dietary Fats 3.9418296743
MESH:D005756 Gastritis Acetaminophen 4.1916983495
MESH:D006333 Heart Failure pirinixic acid 2.7120558911
MESH:D006529 Hepatomegaly pirinixic acid 3.4119772884 16221962 18467677 19176532
MESH:D006849 Hydrocephalus Valproic Acid 5.3317688650
MESH:D006930 Hyperalgesia Acetaminophen 2.9516870215
MESH:D006937 Hypercholesterolemia Dietary Fats 3.9221332399
MESH:D006943 Hyperglycemia pirinixic acid 3.4920558911
MESH:D006949 Hyperlipidemias Dietary Fats 3.9721332399
MESH:D007249 Inflammation Dietary Fats 2.5720412841
MESH:D007333 Insulin Resistance Dietary Fats 7.8911836018 18457598
MESH:D007333 Insulin Resistance pirinixic acid 7.8916306350
MESH:D007674 Kidney Diseases Acetaminophen 2.3612587719 15629191
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 2.1916294345 17596541
MESH:D008103 Liver Cirrhosis Dietary Fats 3.0318296743
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 1.3515474484
MESH:D008107 Liver Diseases Acetaminophen 1.6916611625 19784758 12587719 19014921 16610002 19460945 11587558 12969438
MESH:D017114 Liver Failure, Acute Acetaminophen 3.5416871587 17185352
MESH:D008113 Liver Neoplasms pirinixic acid 1.9120007298 15890375 16377806
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 4.7817228818
MESH:D008546 Melanoma, Experimental Acetaminophen 3.9819513568
MESH:D008881 Migraine Disorders Valproic Acid 3.4118765137 18803445
MESH:D009135 Muscular Diseases pirinixic acid 3.9216239165
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 4.358888407
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 3.3117596541
MESH:D009203 Myocardial Infarction pirinixic acid 2.2519151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.1916411023
MESH:D009369 Neoplasms pirinixic acid 2.0817405874
MESH:D009436 Neural Tube Defects Valproic Acid 3.328888407 16359493
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.1418514411
MESH:D009765 Obesity Dietary Fats 4.6416723640 21332399 19632207 17217161 11836018 18457598 18674790 20132043 20518802
MESH:D009765 Obesity pirinixic acid 4.6420558911
MESH:D010146 Pain Acetaminophen 2.6516870215
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 4.2920603192
MESH:D019310 Pseudolymphoma Valproic Acid 5.0612752131 11422049
MESH:D015427 Reperfusion Injury pirinixic acid 2.5219058328
MESH:D012208 Rhabdomyosarcoma Valproic Acid 4.5319155313
MESH:D012559 Schizophrenia Valproic Acid 2.1015737665 19110320
MESH:D012640 Seizures Valproic Acid 2.943137016 15475178 11044598 16876388 14763951 11738929 1511512 17978042
MESH:D016135 Spinal Dysraphism Valproic Acid 4.0219490988
MESH:D013226 Status Epilepticus Valproic Acid 5.0612833885
MESH:D014178 Translocation, Genetic Valproic Acid 5.7517262798
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.983119515
MESH:D014564 Urogenital Abnormalities Valproic Acid 5.068888407
MESH:D014581 Urticaria Acetaminophen 3.3310982225
MESH:D015430 Weight Gain Dietary Fats 4.0216723640
No data
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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