AutismKB 2.0

Annotation Detail for CYBA


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Basic Information Top
Gene Symbol:CYBA ( p22-PHOX )
Gene Full Name: cytochrome b-245, alpha polypeptide
Band: 16q24.2
Quick LinksEntrez ID:1535; OMIM: 608508; Uniprot ID:CY24A_HUMAN; ENSEMBL ID: ENSG00000051523; HGNC ID: 2577
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04670Leukocyte transendothelial migration
hsa04145Phagosome
hsa05140Leishmaniasis
No data
Pathway IDPathway Name
200190RAC1 signaling pathway
No data
No data
Related Diseases/Disorders Top
Desease IDDesease Name
H00098Chronic granulomatous disease
Immune system diseases
Primary immunodeficiency
Desease IDDesease Name
1809HIV infection
1857Porcine reproductive and respiratory syndrome
1904Diabetes mellitus
1914Cerebrovascular disorder
1918Atherosclerosis
1936Hypercholesterolemia
1959Granulomatous disease
2025Polyarthritis
2032Kidney disease
2040Hyperglycemia
2051Leukemia
2074Asthma
2083IGA glomerulonephritis
2178Retinal disease
2236Cardiovascular disease
Desease Name
cholesterol
periodontitis
hypertension NADPH oxidase activity
Atherosclerosis
atherosclerosis, coronary
CARDIOVASCULAR
Coronary Artery Disease
vascular NAD(P)H oxidase activity
Kidney Failure, Acute
cardiac death cardiovascular disease oxidative stress
coronary endothelial vasodilator function
CANCER
RENAL
hypertension
cardiovascular
IMMUNE
hypertension vascular aging
METABOLIC
obesity
NADPH Oxidase
cerebrovascular disease
cervical intraepithelial neoplasia grade 3
vasodilation, flow-mediated
coronary heart disease in younger individuals.
oxidative stress
Insulin Resistance
No data
Desease Name
Chronic granulomatous disease, autosomal, due to deficiency of CYBA
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of CYBA mRNAaffects expression 17562736
D000643 Ammonium Chloride Ammonium Chloride affects the expression of CYBA mRNAaffects expression 16483693
D001151 Arsenic CYBA gene polymorphism affects the susceptibility to Arsenicaffects response to substance 16076760
C006632 arsenic trioxide arsenic trioxide results in increased expression of CYBA mRNAincreases expression 15070760
C015001 arsenite arsenite results in increased expression of CYBA mRNAincreases expression 10720412
C015001 arsenite CYBA protein promotes the reaction [arsenite results in increased abundance of Superoxides]increases abundance|increases reaction 10720412
C055494 caffeic acid phenethyl ester caffeic acid phenethyl ester inhibits the reaction [Diethylnitrosamine results in increased expression of CYBA mRNA]decreases reaction|increases expression 20360939
D002251 Carbon Tetrachloride Carbon Tetrachloride results in increased expression of CYBA mRNAincreases expression 17854599
C513821 CPU0213 CPU0213 inhibits the reaction [Isoproterenol results in increased expression of CYBA mRNA]decreases reaction|increases expression 18594475
D004041 Dietary Fats Dietary Fats results in decreased expression of CYBA mRNAdecreases expression 18042831
D004052 Diethylnitrosamine caffeic acid phenethyl ester inhibits the reaction [Diethylnitrosamine results in increased expression of CYBA mRNA]decreases reaction|increases expression 20360939
D004052 Diethylnitrosamine Diethylnitrosamine results in increased expression of CYBA mRNAincreases expression 20360939
D004958 Estradiol Estradiol affects the expression of CYBA mRNAaffects expression 16195479
16684588
D000431 Ethanol Ethanol results in decreased expression of CYBA mRNAdecreases expression 17920746
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of CYBA mRNAincreases expression 17555576
17942748
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of CYBA mRNAincreases expression 17557909
D019833 Genistein Genistein results in decreased expression of CYBA mRNAdecreases expression 16705744
D007545 Isoproterenol CPU0213 inhibits the reaction [Isoproterenol results in increased expression of CYBA mRNA]decreases reaction|increases expression 18594475
D007545 Isoproterenol Isoproterenol results in increased expression of CYBA mRNAincreases expression 18594475
D007545 Isoproterenol pimagedine inhibits the reaction [Isoproterenol results in increased expression of CYBA mRNA]decreases reaction|increases expression 18594475
D008070 Lipopolysaccharides CYBA protein affects the reaction [Lipopolysaccharides results in increased expression of ICAM1 mRNA]affects reaction|increases expression 18414230
D008070 Lipopolysaccharides CYBA protein affects the reaction [Lipopolysaccharides results in increased expression of ICAM1 protein]affects reaction|increases expression 18414230
D008070 Lipopolysaccharides CYBA protein affects the reaction [Lipopolysaccharides results in increased secretion of IL8 protein]affects reaction|increases secretion 18414230
C052753 nebivolol nebivolol inhibits the reaction [AGT protein results in increased expression of CYBA mRNA]decreases reaction|increases expression 16940222
C041786 palm oil palm oil results in decreased expression of CYBA mRNAdecreases expression 18042831
D052638 Particulate Matter Particulate Matter results in increased expression of CYBA mRNAincreases expression 18599801
D019800 Phenol Phenol results in increased expression of CYBA mRNAincreases expression 16785328
C004479 pimagedine pimagedine inhibits the reaction [Isoproterenol results in increased expression of CYBA mRNA]decreases reaction|increases expression 18594475
C006253 pirinixic acid pirinixic acid results in decreased expression of CYBA mRNAdecreases expression 17426115
11798191
D010936 Plant Extracts Plant Extracts affects the reaction [AGT protein results in increased expression of CYBA mRNA]affects reaction|increases expression 18047924
D028321 Plant Preparations Plant Preparations results in decreased expression of CYBA mRNAdecreases expression 19450372
D028321 Plant Preparations Plant Preparations results in decreased expression of CYBA proteindecreases expression 19450372
C025299 polyphenols polyphenols results in decreased expression of CYBA mRNAdecreases expression 19450372
C025299 polyphenols polyphenols results in decreased expression of CYBA proteindecreases expression 19450372
D011374 Progesterone Progesterone results in increased expression of CYBA mRNAincreases expression 16195479
D017257 Ramipril Ramipril results in decreased expression of CYBA mRNAdecreases expression 16891913
C017947 sodium arsenite sodium arsenite results in increased expression of CYBA proteinincreases expression 19414066
D013481 Superoxides CYBA protein promotes the reaction [arsenite results in increased abundance of Superoxides]increases abundance|increases reaction 10720412
D013629 Tamoxifen Tamoxifen affects the expression of CYBA mRNAaffects expression 17555576
C004648 testosterone enanthate testosterone enanthate affects the expression of CYBA mRNAaffects expression 17440010
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of CYBA mRNAincreases expression 16051281
20106945
D014212 Tretinoin Tretinoin results in increased expression of CYBA mRNAincreases expression 16054129
17218384
C030665 triphenyltin triphenyltin results in increased expression of CYBA proteinincreases expression 12788061
D015054 Zymosan Zymosan affects the localization of CYBA proteinaffects localization 19005069
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.1914745880
MESH:D000014 Abnormalities, Drug-Induced Ethanol 7.3017676605 18926900
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 7.3015322242 14514962 11752688
MESH:D000138 Acidosis Ammonium Chloride 9.2918287403
MESH:D000138 Acidosis Ethanol 9.2911192467
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.5817505938
MESH:D058186 Acute Kidney Injury Superoxides 4.7918460982
MESH:D055371 Acute Lung Injury Lipopolysaccharides 13.5618653653 11850527
MESH:D055371 Acute Lung Injury Particulate Matter 13.5612396868
MESH:D055371 Acute Lung Injury pirinixic acid 13.5618653653
MESH:D000230 Adenocarcinoma arsenic trioxide 9.3511798837 19825857
MESH:D000230 Adenocarcinoma Estradiol 9.3511473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 9.3514692618
MESH:D000230 Adenocarcinoma Genistein 9.3511473722
MESH:D000236 Adenoma Diethylnitrosamine 2.656695378 10737359
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 15.2217620307 19061943 19052882 17162532 16434500 18056438
MESH:D018248 Adenoma, Liver Cell pirinixic acid 15.2216434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 15.2216835633
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.3415276417
MESH:D018246 Adrenocortical Adenoma Arsenic 12.5917306315
MESH:D018246 Adrenocortical Adenoma sodium arsenite 12.5917306315 16712894
MESH:D020268 Alcohol-Induced Disorders, Nervous System Ethanol 4.9615451040 15451039
MESH:D000505 Alopecia Tretinoin 3.3415955085
MESH:D000544 Alzheimer Disease Particulate Matter 4.7415513908
MESH:D000544 Alzheimer Disease Plant Extracts 4.7416962711
MESH:D000740 Anemia Tetrachlorodibenzodioxin 7.9811748828
MESH:D000740 Anemia Zymosan 7.9818664788
MESH:D000756 Anemia, Sideroblastic Superoxides 5.3116910769
MESH:D000799 Angioedema Acetaminophen 3.4810982225
MESH:D000853 Anophthalmos Ethanol 4.4715513904
MESH:D001008 Anxiety Disorders Ethanol 3.7311141031
MESH:D020261 Arsenic Poisoning Arsenic 2.7616251483 16835338 18414634 12569548
MESH:D001161 Arteriosclerosis Dietary Fats 8.7615238619
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 8.7611256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 15.7915885639
MESH:D001169 Arthritis, Experimental Plant Extracts 15.7914686799
MESH:D001169 Arthritis, Experimental Tretinoin 15.7916412693
MESH:D001169 Arthritis, Experimental Zymosan 15.7916872482 15188379 17659584 15944321 15142272
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.1816292516
MESH:D001249 Asthma Tretinoin 2.2316456186
MESH:D050197 Atherosclerosis Arsenic 6.8212928151 19371607
MESH:D050197 Atherosclerosis Ramipril 6.8211835907
MESH:D001321 Autistic Disorder Acetaminophen 1.4618445737
MESH:D001471 Barrett Esophagus Tretinoin 4.0616935849
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 19.3516206674
MESH:D001778 Blood Coagulation Disorders pirinixic acid 19.3519483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 19.3512125929
MESH:D001778 Blood Coagulation Disorders Tretinoin 19.3516206674 16197459
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.4315340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.5415746008
MESH:D001859 Bone Neoplasms Phenol 4.8810556009
MESH:D001913 Bowen's Disease Phenol 5.3919293009
MESH:D001919 Bradycardia Isoproterenol 4.836740701
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 4.9817868700
MESH:D001930 Brain Injuries Progesterone 3.9115665606 15380490 15845082
MESH:D002545 Brain Ischemia Plant Extracts 4.3816041641
MESH:D001943 Breast Neoplasms Dietary Fats 5.4420435547
MESH:D001943 Breast Neoplasms Diethylnitrosamine 5.4417474063
MESH:D001943 Breast Neoplasms Estradiol 5.4417289903 18497071 19861407 17261762 14630087 16675129 17018787 12948864
MESH:D001943 Breast Neoplasms Genistein 5.4417200150 16541309 16873071
MESH:D001943 Breast Neoplasms Plant Preparations 5.4417398067
MESH:D001943 Breast Neoplasms Progesterone 5.4417614352 15562024 16175315
MESH:D001943 Breast Neoplasms Tamoxifen 5.4418351453 19289846 19189212 19200415 17893378 21138602 19189210 17049068 19155303 19103187 19059307 19410462 19221464 18821012 19142967 19244106 11161223 16818667 20135344 19487384 16202921 18984771 18855134 20005174 16273361 20390343 18815881 18997820 19066611 18425577 19084267 20065188 17242785 19288272 19011961 21152245 18629630 17261762 19115204 17440819 16873071 20859285 15565566 15668708 20544844
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 5.4420435547
MESH:D001943 Breast Neoplasms Tretinoin 5.4416873071 16443354 16166294
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.2416813970
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.0011589617
MESH:D002056 Burns Ethanol 4.3116374292
MESH:D002057 Burns, Chemical Plant Extracts 4.979625245
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.1116111702
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.433786805 15700767 16124888 15721981 16097048 18705752 16011737 15673190 10355542 16227642 16050911 16192424
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.5216835633
MESH:D002280 Carcinoma, Basal Cell Arsenic 3.3917687452 15504454
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.1619066611
MESH:D018236 Carcinoma, Embryonal Tretinoin 4.8016168501
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 27.783084413
MESH:D006528 Carcinoma, Hepatocellular Arsenic 27.7817306315 16507464
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 27.7811135700 14691202 15073043 16217749 15553829
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 27.7818788625
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 27.7816807293 18210153 16681979 16328049 18494052 19539802 11831363 18393292 19822196 17761372 3581430 19171122 16698587 19208518 18978308 17978847 19394651 16878318 16830150 20727157 20432363 20514400 19335982 3084413 20935162 17138121 18785209 19052882 20084675 18788625 17173139 16502159 16288022 10672840 19519916 20512989 19701751 18665156 20524982 20101231 17428255 19919837 18506893 17055752 18056438 16569478 21159647 19418558 16540662 10737359 20007298 16935385 18691550 19107877 16779866 20214788 19383236 17162532 18971187
MESH:D006528 Carcinoma, Hepatocellular Estradiol 27.7816924424
MESH:D006528 Carcinoma, Hepatocellular Ethanol 27.7815289165 15763234 18788625
MESH:D006528 Carcinoma, Hepatocellular Genistein 27.7816924424
MESH:D006528 Carcinoma, Hepatocellular Plant Extracts 27.7818834353
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 27.7816507464 17306315 15276417
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 27.7816924424
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 27.781917145
MESH:D002291 Carcinoma, Papillary arsenic trioxide 4.5119014326
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 3.8112490120
MESH:D002294 Carcinoma, Squamous Cell Arsenic 9.9415504454 18922899 17687452
MESH:D002294 Carcinoma, Squamous Cell Plant Preparations 9.9417418620
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 9.9418572023
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 9.9416096774 16051514
MESH:D002295 Carcinoma, Transitional Cell Arsenic 8.4918640142
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 8.4917572228
MESH:D006332 Cardiomegaly Ethanol 14.7719332462
MESH:D006332 Cardiomegaly Isoproterenol 14.777544033 11179087
MESH:D006332 Cardiomegaly Plant Extracts 14.7717645561
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 14.7716120746 18670907 18850075
MESH:D009202 Cardiomyopathies pimagedine 4.6416612575
MESH:D002318 Cardiovascular Diseases Arsenic 15.4617938729 15738583 19152805
MESH:D002318 Cardiovascular Diseases Genistein 15.4616332659
MESH:D002318 Cardiovascular Diseases Particulate Matter 15.4612396868
MESH:D002318 Cardiovascular Diseases Plant Preparations 15.4616862667
MESH:D002340 Carotid Artery Diseases Arsenic 4.0118022660 16973168
MESH:D016893 Carotid Stenosis Plant Preparations 5.7815158307
MESH:D002386 Cataract Acetaminophen 11.3110977129
MESH:D002386 Cataract pimagedine 11.3115003327 17936468
MESH:D002386 Cataract Tretinoin 11.3117460283
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 9.807505956 21159647 17174075 2727394
MESH:D002471 Cell Transformation, Neoplastic Estradiol 9.8018566989
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 9.8019524636 20056578
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.2416129372
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 8.3419052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 8.3416835633
MESH:D002779 Cholestasis Ethinyl Estradiol 6.8811677210 16105132 17333356 15861022 17110522 16919318 17681005
MESH:D002779 Cholestasis pirinixic acid 6.8819176532
MESH:D002822 Choriocarcinoma Tretinoin 4.8016461808
MESH:D002971 Cleft Lip Ethanol 3.4015513904
MESH:D002972 Cleft Palate Ethanol 8.9415513904
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 8.9412621046 16354765 8697196 15668235 15340226
MESH:D002972 Cleft Palate Tretinoin 8.949407595
MESH:D003092 Colitis Tretinoin 3.3617035595
MESH:D003110 Colonic Neoplasms arsenite 5.5315037631
MESH:D003110 Colonic Neoplasms Genistein 5.5317182828
MESH:D003110 Colonic Neoplasms polyphenols 5.5316293270
MESH:D015179 Colorectal Neoplasms arsenic trioxide 1.8520501625
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.7617141729 14669216
MESH:D003324 Coronary Artery Disease Plant Preparations 3.8615158307
MESH:D023903 Coronary Restenosis arsenic trioxide 3.8512609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 5.0510525206
MESH:D019465 Craniofacial Abnormalities Ethanol 5.0510194807 19302082 15513904 11198716 11873399 15451040 15451039
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 5.0515322242 20055451 10048152
MESH:D019465 Craniofacial Abnormalities Tretinoin 5.059224671 9125849 9211117 14991402 16925845 9664655 9142499 17551590 8800419 10589399
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 3.7715213294
MESH:D003711 Demyelinating Diseases Tamoxifen 4.0219031437
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.2618249437
MESH:D003921 Diabetes Mellitus, Experimental marker/mechanism 11812764
MESH:D003921 Diabetes Mellitus, Experimental Ramipril 5.2211508273
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 6.5320387270
MESH:D003924 Diabetes Mellitus, Type 2 Genistein 6.5316647724
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 6.5317107852
MESH:D003928 Diabetic Nephropathies Estradiol 13.3719279558
MESH:D003928 Diabetic Nephropathies Plant Extracts 13.3719706694
MESH:D003928 Diabetic Nephropathies Tamoxifen 13.3719279558
MESH:D003929 Diabetic Neuropathies Progesterone 4.1517187935
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 13.7619739265 12153990 12958197 11461765 19420014 19416960 16227642 16781746 10915739 14725611 19923254 18071297 2444490 18713872 16081117 12705907 15968718 10663392 16177239 10774834 19085960 19370779 17906064 17562736 11421492 19164858 11834606 16485898 16109766 12594235 14986274 12392966 11287661 16393943 17522070 11529661 15619225 11743745 12540782 14550746 11739529
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 13.769327722 3732212 15027814 19336974 6884620 3786805 10915739 7120509 10092053 6623471 7179309 16177239 16227642 15968718 17522070 15998439 4309450 11566570 21278145 7440962 2869522 19085960
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 13.7619107877
MESH:D056486 Drug-Induced Liver Injury Ethanol 13.7611566570
MESH:D056486 Drug-Induced Liver Injury polyphenols 13.7619370779
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 13.7620420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.7419426721
MESH:D004362 Drug Toxicity Plant Preparations 7.6111033412
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 7.6111462148
MESH:D050171 Dyslipidemias Dietary Fats 3.2018367378
MESH:D004487 Edema pirinixic acid 13.9312083418
MESH:D004487 Edema Plant Extracts 13.9312787963
MESH:D004487 Edema Tetrachlorodibenzodioxin 13.9312711302 11000095
MESH:D004487 Edema Zymosan 13.937907874
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 10.7416714409 18230668 15322242
MESH:D004489 Edema, Cardiac Tretinoin 10.7418230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 13.3812538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 13.3817692515
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 13.3819031437
MESH:D004714 Endometrial Hyperplasia Genistein 4.2316402032
MESH:D016889 Endometrial Neoplasms Estradiol 15.8718566989 11473722 19148513
MESH:D016889 Endometrial Neoplasms Genistein 15.8711473722
MESH:D016889 Endometrial Neoplasms Tamoxifen 15.8716202921 20544844 17893378 19155303
MESH:D016889 Endometrial Neoplasms Tretinoin 15.8716569247
MESH:D004715 Endometriosis Progesterone 7.9116134523
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 7.9110568697 9294722
MESH:D004719 Endomyocardial Fibrosis Plant Extracts 5.3215268973
MESH:D019446 Endotoxemia Lipopolysaccharides 4.0415328337 15821434 17637181
MESH:D004827 Epilepsy Plant Extracts 3.5519700373 19439326
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 4.7616302075
MESH:D004938 Esophageal Neoplasms arsenic trioxide 6.9212903497
MESH:D004938 Esophageal Neoplasms Ethanol 6.9216704527
MESH:D004938 Esophageal Neoplasms Plant Preparations 6.9216510608
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 7.9611564622
MESH:D005124 Eye Abnormalities Tretinoin 7.969664655 16938888
MESH:D005234 Fatty Liver arsenic trioxide 49.6915073043
MESH:D005234 Fatty Liver arsenite 49.6918296743
MESH:D005234 Fatty Liver Carbon Tetrachloride 49.6915959796 16045604 61145 17595544 19224547 16239168 12795759 12631006
MESH:D005234 Fatty Liver Dietary Fats 49.6917967931 19004024 18296743 19551842
MESH:D005234 Fatty Liver Diethylnitrosamine 49.6921071580 20387270
MESH:D005234 Fatty Liver Ethanol 49.6919236843 16409862 18620774
MESH:D005234 Fatty Liver Ethinyl Estradiol 49.6915345470
MESH:D005234 Fatty Liver pirinixic acid 49.6920131406 19236843
MESH:D005234 Fatty Liver Plant Extracts 49.6915975614
MESH:D005234 Fatty Liver Tamoxifen 49.6919224547 14986274
MESH:D005235 Fatty Liver, Alcoholic Ethanol 5.3017920746
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.0216709447
MESH:D005310 Fetal Alcohol Syndrome Ethanol 4.9416946407 10194807 15451040 15513904
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.1111858732
MESH:D005334 Fever Lipopolysaccharides 3.7111852909 9205823
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.1714745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 3.8319069698
MESH:D005355 Fibrosis arsenite 24.0618296743
MESH:D005355 Fibrosis Carbon Tetrachloride 24.0618705752
MESH:D005355 Fibrosis Dietary Fats 24.0618296743
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 24.0620067830
MESH:D005355 Fibrosis Tretinoin 24.0617994277
MESH:D005534 Foot Diseases Arsenic 5.206392382
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 3.9316904648
MESH:D005756 Gastritis Acetaminophen 9.9316983495
MESH:D005756 Gastritis Ethanol 9.9315046732
MESH:D005833 Genital Neoplasms, Female sodium arsenite 4.3216452187
MESH:D005909 Glioblastoma Genistein 6.4416598420
MESH:D005909 Glioblastoma Tretinoin 6.4417312396
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.2310696789
MESH:D006105 Granulomatous Disease, Chronic marker/mechanism
OMIM:233690 GRANULOMATOUS DISEASE, CHRONIC, AUTOSOMAL RECESSIVE, CYTOCHROME b-NEGATIVE marker/mechanism
MESH:D006258 Head and Neck Neoplasms Tretinoin 2.9516096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 4.8016084493
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 5.9010048152 11294989
MESH:D006330 Heart Defects, Congenital Tretinoin 5.909664655 14991402
MESH:D006331 Heart Diseases marker/mechanism 16330681
MESH:D006333 Heart Failure Isoproterenol 10.7618097624
MESH:D006333 Heart Failure pirinixic acid 10.7620558911
MESH:D006333 Heart Failure Plant Extracts 10.7618097624
MESH:D006463 Hemolytic-Uremic Syndrome Lipopolysaccharides 4.0816366002
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.0211000095
MESH:D006505 Hepatitis Carbon Tetrachloride 8.5419900420 19110552
MESH:D006505 Hepatitis Zymosan 8.5419110552
MESH:D006529 Hepatomegaly pirinixic acid 7.1216221962 18467677 19176532 19772884
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 7.1212621046 16120746 15340226
MESH:D006558 Herpes Genitalis Estradiol 4.6715709030
MESH:D006561 Herpes Simplex Plant Extracts 4.2710715843
MESH:D015658 HIV Infections Plant Extracts 3.4912878215
MESH:D019247 HIV Wasting Syndrome testosterone enanthate 5.3917440010
MESH:D006689 Hodgkin Disease sodium arsenite 2.8712676792
MESH:D019584 Hot Flashes Estradiol 9.1417088409
MESH:D019584 Hot Flashes Plant Extracts 9.1417454163 16566672 14716179
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.6816959395 16354765 18606429 15340226 8697196
MESH:D006930 Hyperalgesia Acetaminophen 11.4716870215
MESH:D006930 Hyperalgesia Ethanol 11.4718783367
MESH:D006930 Hyperalgesia Tretinoin 11.4716870215
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.1816899240
MESH:D006937 Hypercholesterolemia Dietary Fats 3.2821332399
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.2216778211
MESH:D006943 Hyperglycemia pirinixic acid 8.8320558911
MESH:D006943 Hyperglycemia triphenyltin 8.8310522495
MESH:D020138 Hyperhomocysteinemia Plant Extracts 9.0516484555
MESH:D020138 Hyperhomocysteinemia Superoxides 9.0512615666
MESH:D017488 Hyperkeratosis, Epidermolytic Arsenic 4.1517050553
MESH:D006949 Hyperlipidemias Dietary Fats 8.3721332399
MESH:D006949 Hyperlipidemias Plant Extracts 8.3715975614 15268973
MESH:D006973 Hypertension Arsenic 4.769931084 11953799 16076760
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 4.7618850075 18670907
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 3.7415338365
MESH:D015228 Hypertriglyceridemia triphenyltin 5.6510522495
MESH:D006984 Hypertrophy Isoproterenol 4.8812791704
MESH:D006987 Hypesthesia Arsenic 5.2016093927
MESH:D007021 Hypospadias Ethinyl Estradiol 3.4616569931 16945680
MESH:D007022 Hypotension Isoproterenol 4.476740701
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 4.0615869954
MESH:D007246 Infertility triphenyltin 5.6915205045
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.1412013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 5.8617937319
MESH:D007248 Infertility, Male sodium arsenite 5.8612646999 15346721
MESH:D007249 Inflammation Dietary Fats 29.4820412841
MESH:D007249 Inflammation Diethylnitrosamine 29.4818785209
MESH:D007249 Inflammation Lipopolysaccharides 29.4817237260 17255318 12878042 9205823 17963957
MESH:D007249 Inflammation Plant Extracts 29.4812787963 15997105 16366677 19332304
MESH:D007249 Inflammation polyphenols 29.4816366677
MESH:D007249 Inflammation Progesterone 29.4815869954
MESH:D007249 Inflammation Tamoxifen 29.4819457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 29.4812878042 12200463
MESH:D007249 Inflammation Zymosan 29.4811289658 8014878
MESH:D007333 Insulin Resistance Dietary Fats 10.9518457598 11836018
MESH:D007333 Insulin Resistance Estradiol 10.9516393666 16627594
MESH:D007333 Insulin Resistance pirinixic acid 10.9516306350
MESH:D007410 Intestinal Diseases pimagedine 14.8011713966
MESH:D007410 Intestinal Diseases Superoxides 14.8010210152
MESH:D007410 Intestinal Diseases Tretinoin 14.8017994277
MESH:D007414 Intestinal Neoplasms caffeic acid phenethyl ester 9.2310783313
MESH:D007414 Intestinal Neoplasms Plant Extracts 9.2312584176 12351151 12628509
MESH:D019189 Iron Metabolism Disorders Lipopolysaccharides 4.3017255318
MESH:D043183 Irritable Bowel Syndrome Zymosan 5.4817553498
MESH:D007569 Jaw Abnormalities Ethanol 15.3515513904
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 15.3516580747
MESH:D007569 Jaw Abnormalities Tretinoin 15.3515992940 17551590
MESH:D007642 Keratosis Arsenic 4.6416930632 12749816
MESH:D055623 Keratosis, Actinic Phenol 6.0819293009
MESH:D007674 Kidney Diseases Acetaminophen 12.7712587719 15629191
MESH:D007674 Kidney Diseases caffeic acid phenethyl ester 12.7715369732
MESH:D007674 Kidney Diseases Estradiol 12.7715618244
MESH:D007674 Kidney Diseases sodium arsenite 12.7720008137
MESH:D007680 Kidney Neoplasms Estradiol 6.4415610895
MESH:D007680 Kidney Neoplasms Tamoxifen 6.4418625569
MESH:D007859 Learning Disorders Ethanol 3.8715451040
MESH:D007938 Leukemia arsenic trioxide 9.4415070760
MESH:D007938 Leukemia Genistein 9.4417468513 18980019
MESH:D007938 Leukemia Tretinoin 9.4417143497
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 3.4812560223 17077332
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 3.9516972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.1714633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 8.4219077051
MESH:D007951 Leukemia, Myeloid Tretinoin 8.4216932348 19285840 16482212
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 3.6416968895 16467208 20471514 19850784 17050201
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 3.6419850784 16294345 17596541
MESH:D015473 Leukemia, Promyelocytic, Acute Arsenic 16.3117339181
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 16.3115336539 15213294 16330433 11468182 19225113 12712474 17869043 17217047 16966277 19642359 12679006 17649720 11161223 16823087 15748426 16891316 16331271 17107899 19075265 12018890 15622746 9834237 19035177 17712046 16112521
MESH:D015473 Leukemia, Promyelocytic, Acute caffeic acid phenethyl ester 16.3116766008
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 16.319834237 16766008 17712046 19029980 16331271 17506722 17107899 16140955 17339181 12679006 17368321 17217047 15748426 19225113 19035177 16823087 16788101 17361223 19642359 16935935 19075265 17649720 17301526 17294898 16891316
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.0216882451
MESH:D007970 Leukopenia Lipopolysaccharides 4.3415821434
MESH:D017880 Limb Deformities, Congenital Ethanol 7.4817676605
MESH:D017880 Limb Deformities, Congenital Tretinoin 7.489224671
MESH:D008064 Lipidoses Tamoxifen 2.9017567588 15342952
MESH:D008103 Liver Cirrhosis arsenite 23.3418296743
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 23.3417157831 16943688 11903743 11408273 16239168 21278145 16221502 17334410 17174718
MESH:D008103 Liver Cirrhosis Dietary Fats 23.3418296743
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 23.3419638242 18665156 18522880 18407596 20032147
MESH:D008103 Liver Cirrhosis Ethanol 23.3415289165
MESH:D008103 Liver Cirrhosis Plant Extracts 23.3417157831
MESH:D008104 Liver Cirrhosis, Alcoholic Ethanol 4.7418295389
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 19.7312546737 17922224 17481882 15123356 15925388 17631135 18006644 18166357 18412020 20821823 14620537 18705752 17557913 12632512 12389079 16192424 17761835 18187930 17698563 17900296 15818738 12741479 14748882 17721639 15370692 15893842 14512876 18420326 17823541 15959796 12666154 17976157 17714472 18395095 14716496 12586293 17869086 14716833 18395914 17766677 17708605 18472094 16136751 17944888 18376398 16033810 18251166 14724832 18472332 16638106 16015684 15931870 12445418 15052691 12898905 15650968 18054572 18481824 16248980 15996030 18205269 18339082 15876570 18317297 18210741 17565644 15730626 12958196 15673190 18263696 18429990 16097048 18156304 15057751 12632514 12609069 16027843 16011737 13678700 18277467 15338365 18279442 17640975 12649538 12667390 16116963 12445421 11481614 17525996 15362042 18418968 10355542 17805973
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 19.7314659978 14716833
MESH:D008106 Liver Cirrhosis, Experimental Ethanol 19.7318166357
MESH:D008106 Liver Cirrhosis, Experimental Genistein 19.7317823541
MESH:D008106 Liver Cirrhosis, Experimental Lipopolysaccharides 19.7312878042
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 19.7315474484
MESH:D008106 Liver Cirrhosis, Experimental Plant Extracts 19.7315479170
MESH:D008106 Liver Cirrhosis, Experimental Plant Preparations 19.7317724770
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 19.7318564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 19.7312878042
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 19.7318397230 16248980
MESH:D008107 Liver Diseases Acetaminophen 14.5516611625 19460945 12969438 19014921 19784758 11587558 12587719 16610002
MESH:D008107 Liver Diseases Arsenic 14.5511134558
MESH:D008107 Liver Diseases Carbon Tetrachloride 14.5516964402 15830285 16246199 15720792 17285989
MESH:D008107 Liver Diseases Diethylnitrosamine 14.5517034775
MESH:D008107 Liver Diseases Plant Extracts 14.5517034775
MESH:D008107 Liver Diseases polyphenols 14.5516698588
MESH:D008108 Liver Diseases, Alcoholic Ethanol 4.3117347304 17207112
MESH:D017093 Liver Failure Carbon Tetrachloride 3.8215123358
MESH:D017114 Liver Failure, Acute Acetaminophen 8.3916871587 17185352
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 8.3914706259 16899240
MESH:D008113 Liver Neoplasms Arsenic 27.3316368122
MESH:D008113 Liver Neoplasms arsenic trioxide 27.3314682389
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 27.3319294768
MESH:D008113 Liver Neoplasms Diethylnitrosamine 27.3315885732 18648771 19642983 19690152 16942905 20452335 21047994 19812893 10737359 15175105 21167192 19294768 19499222 19254457 20583210 18644402 19638242 12112319 12771043 18754104 21278145 20101389 19255062 18977376 20492335 20501860 19833225 19850985 20137499 20118626 19426721 19090486 19996281 2422723 20405173 20434301 2862719 18978307 19073162 19551842 19427195 19256749 9163691 21071580
MESH:D008113 Liver Neoplasms pirinixic acid 27.3320007298 16377806 15890375
MESH:D008113 Liver Neoplasms Plant Extracts 27.3319168119
MESH:D008113 Liver Neoplasms sodium arsenite 27.3316712894 15276417
MESH:D008113 Liver Neoplasms Tamoxifen 27.3316684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 27.3316984957
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 12.2820377131
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 12.2812014681 15583823
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 12.2818253720 18079962 19519916 18544905 3124819 19539802 19126423 18775883 18093689 16267830 18164116 19009564 17942915 21159647 9362446 17174075 16842330 17854601 18308698 2563599 18282651 19004024
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 12.2812151625
MESH:D008133 Long QT Syndrome arsenic trioxide 3.0815213294
MESH:D008171 Lung Diseases sodium arsenite 2.9419095001
MESH:D055370 Lung Injury Lipopolysaccharides 3.6721114838
MESH:D008175 Lung Neoplasms Arsenic 12.1019168569 17976673 17306315
MESH:D008175 Lung Neoplasms arsenic trioxide 12.1019825857 11798837
MESH:D008175 Lung Neoplasms arsenite 12.1016809336
MESH:D008175 Lung Neoplasms Diethylnitrosamine 12.1020970405 21163286 6695378 20512841
MESH:D008175 Lung Neoplasms Plant Extracts 12.1020869020
MESH:D008175 Lung Neoplasms sodium arsenite 12.1017306315 17077188 16712894 19931552 15276417
MESH:D008175 Lung Neoplasms Tamoxifen 12.1018625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 12.1011884234 19555203
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 3.4119428831
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 12.4017203775 11807958 11408345 16891317
MESH:D008325 Mammary Neoplasms, Experimental Genistein 12.4014578162 12929590
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 12.4011408345 17203775
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 12.4011731420 19196723 19196722 16827153 14580682
MESH:D020149 Manganese Poisoning Estradiol 11.4419453300
MESH:D020149 Manganese Poisoning Tamoxifen 11.4419453300
MESH:D008527 Medulloblastoma Tretinoin 2.6417453147
MESH:D008545 Melanoma sodium arsenite 4.6819082730 16487513
MESH:D008545 Melanoma Tamoxifen 4.6812393984 19393235
MESH:D008545 Melanoma Tretinoin 4.6816752155
MESH:D018328 Melanoma, Amelanotic Tamoxifen 3.8315990972
MESH:D008546 Melanoma, Experimental Acetaminophen 3.2219513568
MESH:D008569 Memory Disorders Ethanol 3.8518411066 15451040
MESH:D008591 Meningomyelocele Tretinoin 4.0816940565
MESH:D009062 Mouth Neoplasms Plant Preparations 4.5117418620
MESH:D009101 Multiple Myeloma arsenic trioxide 2.8615949261 14977855 11468182 19417148 19549372
MESH:D009102 Multiple Organ Failure Zymosan 4.8810479408 17724436 18160304 15213630 15241586 12130978 12879239 15259001 15834315 10890648
MESH:D009135 Muscular Diseases pirinixic acid 3.1616239165
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.3118349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 6.7116105982 16882451
MESH:D009190 Myelodysplastic Syndromes Tretinoin 6.7117596541
MESH:D009203 Myocardial Infarction Genistein 12.4317141266
MESH:D009203 Myocardial Infarction Isoproterenol 12.4319172585 16697266 16538859 17052832 19595682 15740881 16584858
MESH:D009203 Myocardial Infarction pirinixic acid 12.4319151258
MESH:D009203 Myocardial Infarction Ramipril 12.4311835907
MESH:D017202 Myocardial Ischemia Arsenic 8.0815371236
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 8.0812213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 12.6116810080
MESH:D015428 Myocardial Reperfusion Injury Genistein 12.6117141266
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 12.6116411023
MESH:D009205 Myocarditis Particulate Matter 5.6012563109
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 3.6216624393
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 5.243581430 9029167
MESH:D009362 Neoplasm Metastasis Tamoxifen 5.2419393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.4019410462
MESH:D009369 Neoplasms pirinixic acid 7.1917405874
MESH:D009369 Neoplasms sodium arsenite 7.1911559025
MESH:D009369 Neoplasms Tretinoin 7.1916594593 16946489
MESH:D009374 Neoplasms, Experimental sodium arsenite 3.3220056578
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 3.6419196722 19189210 19200415
MESH:D009389 Neovascularization, Pathologic arsenite 8.9715738583
MESH:D009389 Neovascularization, Pathologic Estradiol 8.9717289903
MESH:D009421 Nervous System Malformations Estradiol 20.6716427766 11399458
MESH:D009421 Nervous System Malformations Genistein 20.6716427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 20.6714600291
MESH:D009421 Nervous System Malformations Tretinoin 20.679125849
MESH:D009436 Neural Tube Defects Arsenic 15.4516620997
MESH:D009436 Neural Tube Defects arsenic trioxide 15.4510525206
MESH:D009436 Neural Tube Defects sodium arsenite 15.4512854658
MESH:D009436 Neural Tube Defects Tretinoin 15.459142499
MESH:D019954 Neurobehavioral Manifestations Plant Extracts 4.8417168769
MESH:D019636 Neurodegenerative Diseases Acetaminophen 7.2318514411
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 7.2320387270
MESH:D020078 Neurogenic Inflammation Arsenic 4.0517056641
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 4.7620387270
MESH:D009765 Obesity Dietary Fats 6.9121332399 19632207 20132043 20518802 11836018 18674790 17217161 18457598 16723640
MESH:D009765 Obesity pirinixic acid 6.9120558911
MESH:D009765 Obesity Plant Extracts 6.9120132043 19056576
MESH:D010024 Osteoporosis Genistein 3.0419401787
MESH:D015663 Osteoporosis, Postmenopausal Genistein 3.7616169203
MESH:D010051 Ovarian Neoplasms Arsenic 21.0917306315
MESH:D010051 Ovarian Neoplasms arsenic trioxide 21.0912452020 19769630 16624393
MESH:D010051 Ovarian Neoplasms Estradiol 21.0919401270
MESH:D010051 Ovarian Neoplasms Genistein 21.0919005980
MESH:D010051 Ovarian Neoplasms Progesterone 21.0916525653 17393432
MESH:D010051 Ovarian Neoplasms sodium arsenite 21.0917306315 15276417
MESH:D010051 Ovarian Neoplasms Tretinoin 21.0916936753
MESH:D010146 Pain Acetaminophen 9.7316870215
MESH:D010146 Pain Phenol 9.7317610455
MESH:D010146 Pain Tretinoin 9.7316870215
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 11.2315580305
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 11.2316540662
MESH:D010190 Pancreatic Neoplasms Ethanol 11.2312384795
MESH:D010190 Pancreatic Neoplasms Tretinoin 11.2315976015
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.3611578682
MESH:D010212 Papilloma Plant Extracts 4.1515173996 16517061
MESH:D010235 Paraganglioma arsenic trioxide 3.8419927285
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 3.8912520081
MESH:D010392 Pemphigus Phenol 6.0816522979 17163923
MESH:D010523 Peripheral Nervous System Diseases Arsenic 3.8416093927
MESH:D016491 Peripheral Vascular Diseases Arsenic 4.646392382 15371236 16905509
MESH:D010538 Peritonitis Zymosan 4.5417371808 15979727 18557954 11985352 19088179 14761945 18977430 18760300 15259001 17826846 19641140
MESH:D010864 Pilonidal Sinus Phenol 6.0819655223 15622588
MESH:D011014 Pneumonia Lipopolysaccharides 4.2011605937 12224865
MESH:D011041 Poisoning Phenol 4.398825745
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.2218163543
MESH:D011230 Precancerous Conditions Diethylnitrosamine 3.262563599
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 2.8411896295 11399792 11118676 11222880
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.5720887781
MESH:D011471 Prostatic Neoplasms Arsenic 2.0416140617
MESH:D011471 Prostatic Neoplasms arsenic trioxide 2.0419131511
MESH:D011471 Prostatic Neoplasms Estradiol 2.0416740699
MESH:D011471 Prostatic Neoplasms Genistein 2.0416925846 15256057 15378649
MESH:D011471 Prostatic Neoplasms Plant Extracts 2.0414666653 17804756
MESH:D011471 Prostatic Neoplasms sodium arsenite 2.0416039940
MESH:D011471 Prostatic Neoplasms Tamoxifen 2.0415067354
MESH:D011507 Proteinuria Arsenic 8.2021343184
MESH:D011507 Proteinuria Tretinoin 8.2016636307
MESH:D011537 Pruritus Ethinyl Estradiol 2.9615861022 16919318
MESH:D011625 Pterygium Tretinoin 4.4416723453
MESH:D011654 Pulmonary Edema Isoproterenol 4.8910903255
MESH:D011658 Pulmonary Fibrosis Particulate Matter 4.0512475806
MESH:D015427 Reperfusion Injury pirinixic acid 6.4419058328
MESH:D015427 Reperfusion Injury Superoxides 6.4418460982
MESH:D012130 Respiratory Hypersensitivity Lipopolysaccharides 3.5010835634
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.5018990726
MESH:D012208 Rhabdomyosarcoma Tretinoin 3.7716283617 16116481
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.7318045962
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 3.6216646077
MESH:D012640 Seizures Ethanol 2.949754883
MESH:D018805 Sepsis Zymosan 4.3611441115
MESH:D012871 Skin Diseases Arsenic 2.6519834688 17938729 18709164 17548696 16702368 16353154 6392382 17453740 17050553 16759981 15952646
MESH:D012878 Skin Neoplasms Arsenic 16.1116251483 15504454 17050553 19538983 17976673 17029826
MESH:D012878 Skin Neoplasms Plant Extracts 16.1115173996 16517061
MESH:D012878 Skin Neoplasms sodium arsenite 16.1119524636 18572023
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 16.1116192470
MESH:D012878 Skin Neoplasms Tretinoin 16.1116467112
MESH:D013088 Spermatocele Ethinyl Estradiol 18.1716709447
MESH:D013088 Spermatocele Phenol 18.1718646496
MESH:D013088 Spermatocele Tamoxifen 18.1716709447
MESH:D013119 Spinal Cord Injuries Progesterone 9.6916503802 15862959
MESH:D013119 Spinal Cord Injuries Tamoxifen 9.6919457130
MESH:D016135 Spinal Dysraphism sodium arsenite 3.5312854658
MESH:D013274 Stomach Neoplasms arsenic trioxide 4.4117007042
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 4.4118456281
MESH:D013274 Stomach Neoplasms Ethanol 4.4118456281
MESH:D013274 Stomach Neoplasms Tretinoin 4.4117261132
MESH:D013276 Stomach Ulcer Ethanol 10.6011906479 9562338 16755016 9211565 17918041 17189318
MESH:D013276 Stomach Ulcer pimagedine 10.6018209962
MESH:D013276 Stomach Ulcer Plant Extracts 10.6017135157 15255614 18193104 18237397 12787963
MESH:D013375 Substance Withdrawal Syndrome Ethanol 3.959754883
MESH:D013705 Temporomandibular Joint Disorders Plant Extracts 12.0717997062
MESH:D013705 Temporomandibular Joint Disorders polyphenols 12.0717997062
MESH:D013921 Thrombocytopenia Lipopolysaccharides 3.8615821434
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.2911994571
MESH:D013927 Thrombosis Ethinyl Estradiol 2.8615669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.5412697716
MESH:D013964 Thyroid Neoplasms arsenic trioxide 10.4319014326
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 10.437505956
MESH:D013964 Thyroid Neoplasms Tretinoin 10.4316026305 17045167
MESH:D013978 Tibial Fractures Estradiol 4.3219048282
MESH:D014062 Tongue Neoplasms Tretinoin 3.4816051514
MESH:D016171 Torsades de Pointes arsenic trioxide 3.6115213294
MESH:D014277 Trigeminal Neuralgia Phenol 6.0816527771 10223447
MESH:D014376 Tuberculosis Tretinoin 3.0116040207
MESH:D001749 Urinary Bladder Neoplasms Arsenic 14.2717976673 11144890 18640142 19322015 19429237 17306315 15987713
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 14.2712973940 20435036 11780464 12845720
MESH:D001749 Urinary Bladder Neoplasms Plant Preparations 14.2711251952
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 14.2716452187 17306315 11723127 16712894
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 14.2717572228 16712894 8653321
MESH:D014581 Urticaria Acetaminophen 2.6510982225
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 8.3911813266
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 8.3916129372
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 2.9614692618
MESH:D014604 Uveal Neoplasms Tretinoin 4.2516752155
MESH:D014605 Uveitis Zymosan 5.0411006244
MESH:D014652 Vascular Diseases Arsenic 10.6717056641
MESH:D014652 Vascular Diseases sodium arsenite 10.6717056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.2312125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.2214671159 15869587
MESH:D018487 Ventricular Dysfunction, Left Isoproterenol 9.6818097624
MESH:D018487 Ventricular Dysfunction, Left Plant Extracts 9.6818097624
MESH:D020257 Ventricular Remodeling Isoproterenol 11.6818097624
MESH:D020257 Ventricular Remodeling Plant Extracts 11.6818097624
MESH:D014820 Vitiligo Tretinoin 3.7216761959
MESH:D014860 Warts Phenol 5.7419122958
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 3.8915886252
MESH:D015430 Weight Gain Dietary Fats 3.4416723640
MESH:D009396 Wilms Tumor Tretinoin 3.6716287080
MESH:D014947 Wounds and Injuries Plant Extracts 3.9720213670 19894650
Pathway ID Pathway Name
KEGG:05140 Leishmaniasis
KEGG:04670 Leukocyte transendothelial migration
KEGG:04380 Osteoclast differentiation
KEGG:04145 Phagosome
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA27075
    • No data
    Releated disease ID Related disease Name
    PA443421Arrhythmias, Cardiac
    PA445018Cardiomyopathies
    PA443937Drug Toxicity
    PA444845Lymphoma, Non-Hodgkin
    Releated drug ID Related drug Name
    PA449412doxorubicin
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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