Annotation Detail for CNKSR3
Basic Information
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| Chemical ID |
Chemical Name |
Interaction |
Interaction Action |
Publication |
|---|
| C023514 |
2,6-dinitrotoluene |
2,6-dinitrotoluene results in decreased expression of CNKSR3 mRNA | decreases expression | 20406850
|
| D000082 |
Acetaminophen |
Acetaminophen affects the expression of CNKSR3 mRNA | affects expression | 17562736
|
| D001564 |
Benzo(a)pyrene |
Benzo(a)pyrene results in decreased expression of CNKSR3 mRNA | decreases expression | 20064835
|
| D015123 |
7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide |
7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide affects the expression of CNKSR3 mRNA | affects expression | 20382639
|
| Disease ID |
Disease Name |
Direct Evidence |
Inference Chemical Name |
Inference Score |
Publication |
|---|
| MESH:D000230 |
Adenocarcinoma |
|
Benzo(a)pyrene |
2.06 | 20127859 20464547 |
| MESH:D000236 |
Adenoma |
|
Benzo(a)pyrene |
2.86 | 6695378 |
| MESH:D000799 |
Angioedema |
|
Acetaminophen |
4.57 | 10982225 |
| MESH:D017544 |
Aortic Aneurysm, Abdominal |
|
Benzo(a)pyrene |
4.64 | 19183758 |
| MESH:D001321 |
Autistic Disorder |
|
Acetaminophen |
1.40 | 18445737 |
| MESH:D001943 |
Breast Neoplasms |
|
Benzo(a)pyrene |
1.99 | 17474063 20146248 |
| MESH:D006528 |
Carcinoma, Hepatocellular |
|
2,6-dinitrotoluene |
2.96 | 16705839 |
| MESH:D006528 |
Carcinoma, Hepatocellular |
|
Acetaminophen |
2.96 | 3084413 |
| MESH:D002294 |
Carcinoma, Squamous Cell |
|
Benzo(a)pyrene |
2.13 | 20419170 |
| MESH:D002386 |
Cataract |
|
Acetaminophen |
2.79 | 10977129 |
| MESH:D002471 |
Cell Transformation, Neoplastic |
|
2,6-dinitrotoluene |
7.53 | 6135515 |
| MESH:D002471 |
Cell Transformation, Neoplastic |
|
7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide |
7.53 | 20889678 |
| MESH:D003490 |
Cyanosis |
|
2,6-dinitrotoluene |
4.58 | 18551238 |
| MESH:D056486 |
Drug-Induced Liver Injury |
|
2,6-dinitrotoluene |
4.02 | 18551238 21346803 |
| MESH:D056486 |
Drug-Induced Liver Injury |
|
Acetaminophen |
4.02 | 19085960 19739265 16109766 19416960 16177239 10915739 16081117 14725611 15968718 11287661 16393943 10663392 16485898 11461765 17562736 14986274 19370779 12153990 12594235 12705907 19164858 11529661 15619225 11421492 2444490 11834606 10774834 18071297 19923254 17522070 19420014 12958197 18713872 17906064 11743745 16781746 11739529 16227642 12392966 12540782 14550746 |
| MESH:D056487 |
Drug-Induced Liver Injury, Chronic |
|
Acetaminophen |
4.82 | 19426721 |
| MESH:D004938 |
Esophageal Neoplasms |
|
7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide |
4.62 | 20426865 |
| MESH:D004938 |
Esophageal Neoplasms |
|
Benzo(a)pyrene |
4.62 | 16530937 |
| MESH:D005756 |
Gastritis |
|
Acetaminophen |
4.40 | 16983495 |
| MESH:D006330 |
Heart Defects, Congenital |
|
Benzo(a)pyrene |
2.83 | 20471113 |
| MESH:D006930 |
Hyperalgesia |
|
Acetaminophen |
3.02 | 16870215 |
| MESH:D007674 |
Kidney Diseases |
|
Acetaminophen |
2.40 | 15629191 12587719 |
| MESH:D007680 |
Kidney Neoplasms |
|
2,6-dinitrotoluene |
3.32 | 16705839 |
| MESH:D008107 |
Liver Diseases |
|
Acetaminophen |
1.70 | 16611625 11587558 19784758 12587719 19460945 16610002 19014921 12969438 |
| MESH:D017114 |
Liver Failure, Acute |
|
Acetaminophen |
3.63 | 16871587 17185352 |
| MESH:D008113 |
Liver Neoplasms |
|
2,6-dinitrotoluene |
4.89 | 7678174 |
| MESH:D008113 |
Liver Neoplasms |
|
Benzo(a)pyrene |
4.89 | 21137059 20195826 |
| MESH:D008114 |
Liver Neoplasms, Experimental |
|
2,6-dinitrotoluene |
2.77 | 2876784 6135515 2876786 |
| MESH:D008175 |
Lung Neoplasms |
|
Benzo(a)pyrene |
1.57 | 20464547 17053015 18520028 20064080 20869020 6695378 18816296 20135361 18569708 |
| MESH:D008546 |
Melanoma, Experimental |
|
Acetaminophen |
4.13 | 19513568 |
| MESH:D009062 |
Mouth Neoplasms |
|
Benzo(a)pyrene |
3.50 | 16381670 |
| MESH:D009336 |
Necrosis |
|
2,6-dinitrotoluene |
4.49 | 7678174 18551238 |
| MESH:D009369 |
Neoplasms |
|
Benzo(a)pyrene |
2.33 | 11141357 |
| MESH:D019636 |
Neurodegenerative Diseases |
|
Acetaminophen |
3.21 | 18514411 |
| MESH:D009784 |
Occupational Diseases |
|
2,6-dinitrotoluene |
3.83 | 16049721 |
| MESH:D010146 |
Pain |
|
Acetaminophen |
2.73 | 16870215 |
| MESH:D011471 |
Prostatic Neoplasms |
|
Benzo(a)pyrene |
2.91 | 17292933 |
| MESH:D012640 |
Seizures |
|
2,6-dinitrotoluene |
2.79 | 18551238 |
| MESH:D012878 |
Skin Neoplasms |
|
Benzo(a)pyrene |
2.52 | 19755658 10029692 |
| MESH:D013274 |
Stomach Neoplasms |
|
Benzo(a)pyrene |
1.56 | 2093021 20155912 |
| MESH:D001749 |
Urinary Bladder Neoplasms |
|
2,6-dinitrotoluene |
5.39 | 16049721 |
| MESH:D001749 |
Urinary Bladder Neoplasms |
|
Benzo(a)pyrene |
5.39 | 17053015 |
| MESH:D014571 |
Urologic Neoplasms |
|
2,6-dinitrotoluene |
4.95 | 10091137 |
| MESH:D014581 |
Urticaria |
|
Acetaminophen |
3.44 | 10982225 |
Related Pathway Information