AutismKB 2.0

Annotation Detail for ADRB3


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Basic Information Top
Gene Symbol:ADRB3 ( BETA3AR,FLJ99960 )
Gene Full Name: adrenergic, beta-3-, receptor
Band: 8p11.23
Quick LinksEntrez ID:155; OMIM: 109691; Uniprot ID:ADRB3_HUMAN; ENSEMBL ID: ENSG00000188778; HGNC ID: 288
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04080Neuroactive ligand-receptor interaction
hsa04020Calcium signaling pathway
hsa04144Endocytosis
hsa04970Salivary secretion
Pathway IDPathway Name
Signaling by GPCR
No data
Pathway IDPathway Name
P04379Beta3 adrenergic receptor signaling pathway
P00026Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1781Rheumatoid arthritis
1795Amnionitis
1918Atherosclerosis
1961Endometrium cancer
2091Hypertension
2044Pre-Eclampsia
2070Cholelithiasis
2111Systemic infection
2197Metabolism disease
Desease Name
cholesterol
glucose
NORMALVARIATION
colorectal cancer
CARDIOVASCULAR
features of the insulin resistance syndrome
energy expenditure
blood pressure
CANCER
Body mass index
Weight Gain
body mass
endometrial cancer
METABOLIC
increased plasma leptin levels
heart rate
obesity
insulin
coronary heart disease among Japanese.
diabetes, type 2
reduced low-density lipoprotein particle size
Insulin Resistance
No data
Desease Name
Obesity, susceptibility to
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C097869 3-(2-ethylphenoxy)-1-(1,2,3,4-tetrahydronaphth-1-ylamino)-2-propanol oxalate 3-(2-ethylphenoxy)-1-(1,2,3,4-tetrahydronaphth-1-ylamino)-2-propanol oxalate binds to and results in decreased activity of ADRB3 proteinaffects binding|decreases activity 12606629
C097869 3-(2-ethylphenoxy)-1-(1,2,3,4-tetrahydronaphth-1-ylamino)-2-propanol oxalate 3-(2-ethylphenoxy)-1-(1,2,3,4-tetrahydronaphth-1-ylamino)-2-propanol oxalate inhibits the reaction [ICI D7114 binds to and results in increased activity of ADRB3 protein]affects binding|decreases reaction|increases activity 12606629
C097869 3-(2-ethylphenoxy)-1-(1,2,3,4-tetrahydronaphth-1-ylamino)-2-propanol oxalate 3-(2-ethylphenoxy)-1-(1,2,3,4-tetrahydronaphth-1-ylamino)-2-propanol oxalate binds to and results in decreased activity of ADRB3 proteinaffects binding|decreases activity 10952688
C097869 3-(2-ethylphenoxy)-1-(1,2,3,4-tetrahydronaphth-1-ylamino)-2-propanol oxalate 3-(2-ethylphenoxy)-1-(1,2,3,4-tetrahydronaphth-1-ylamino)-2-propanol oxalate inhibits the reaction [cyanopindolol binds to ADRB3 protein]affects binding|decreases reaction 10344530
C097869 3-(2-ethylphenoxy)-1-(1,2,3,4-tetrahydronaphth-1-ylamino)-2-propanol oxalate 3-(2-ethylphenoxy)-1-(1,2,3,4-tetrahydronaphth-1-ylamino)-2-propanol oxalate inhibits the reaction [[SR 59119A binds to and results in increased activity of ADRB3 protein] which results in increased abundance of Cyclic AMP]affects binding|decreases reaction|increases abundance|increases activity 10952688
C097869 3-(2-ethylphenoxy)-1-(1,2,3,4-tetrahydronaphth-1-ylamino)-2-propanol oxalate 3-(2-ethylphenoxy)-1-(1,2,3,4-tetrahydronaphth-1-ylamino)-2-propanol oxalate results in increased expression of ADRB3 mRNAincreases expression 10725275
C097869 3-(2-ethylphenoxy)-1-(1,2,3,4-tetrahydronaphth-1-ylamino)-2-propanol oxalate [3-(2-ethylphenoxy)-1-(1,2,3,4-tetrahydronaphth-1-ylamino)-2-propanol oxalate results in increased expression of ADRB3 mRNA] which results in increased susceptibility to CL 316243increases expression|increases response to substance 10725275
C097869 3-(2-ethylphenoxy)-1-(1,2,3,4-tetrahydronaphth-1-ylamino)-2-propanol oxalate 3-(2-ethylphenoxy)-1-(1,2,3,4-tetrahydronaphth-1-ylamino)-2-propanol oxalate results in increased expression of ADRB3 proteinincreases expression 10725275
C097869 3-(2-ethylphenoxy)-1-(1,2,3,4-tetrahydronaphth-1-ylamino)-2-propanol oxalate 3-(2-ethylphenoxy)-1-(1,2,3,4-tetrahydronaphth-1-ylamino)-2-propanol oxalate binds to and results in decreased activity of ADRB3 proteinaffects binding|decreases activity 8569714
9718277
10344530
C097869 3-(2-ethylphenoxy)-1-(1,2,3,4-tetrahydronaphth-1-ylamino)-2-propanol oxalate 3-(2-ethylphenoxy)-1-(1,2,3,4-tetrahydronaphth-1-ylamino)-2-propanol oxalate inhibits the reaction [CGP 12177 results in increased activity of ADRB3 protein]decreases reaction|increases activity 8569714
C097869 3-(2-ethylphenoxy)-1-(1,2,3,4-tetrahydronaphth-1-ylamino)-2-propanol oxalate 3-(2-ethylphenoxy)-1-(1,2,3,4-tetrahydronaphth-1-ylamino)-2-propanol oxalate inhibits the reaction [Isoproterenol results in increased activity of ADRB3 protein]decreases reaction|increases activity 17622774
C097869 3-(2-ethylphenoxy)-1-(1,2,3,4-tetrahydronaphth-1-ylamino)-2-propanol oxalate 3-(2-ethylphenoxy)-1-(1,2,3,4-tetrahydronaphth-1-ylamino)-2-propanol oxalate inhibits the reaction [Norepinephrine results in increased activity of ADRB3 protein]decreases reaction|increases activity 8569714
17622774
C097869 3-(2-ethylphenoxy)-1-(1,2,3,4-tetrahydronaphth-1-ylamino)-2-propanol oxalate 3-(2-ethylphenoxy)-1-(1,2,3,4-tetrahydronaphth-1-ylamino)-2-propanol oxalate inhibits the reaction [SR 58611A results in increased activity of ADRB3 protein]decreases reaction|increases activity 8569714
C097869 3-(2-ethylphenoxy)-1-(1,2,3,4-tetrahydronaphth-1-ylamino)-2-propanol oxalate 3-(2-ethylphenoxy)-1-(1,2,3,4-tetrahydronaphth-1-ylamino)-2-propanol oxalate binds to and results in decreased activity of ADRB3 proteinaffects binding|decreases activity 17622774
D000082 Acetaminophen Acetaminophen affects the expression of ADRB3 mRNAaffects expression 17562736
D000242 Cyclic AMP 3-(2-ethylphenoxy)-1-(1,2,3,4-tetrahydronaphth-1-ylamino)-2-propanol oxalate inhibits the reaction [[SR 59119A binds to and results in increased activity of ADRB3 protein] which results in increased abundance of Cyclic AMP]affects binding|decreases reaction|increases abundance|increases activity 10952688
D000242 Cyclic AMP [SR 59119A binds to and results in increased activity of ADRB3 protein] which results in increased abundance of Cyclic AMPaffects binding|increases abundance|increases activity 10952688
D000638 Amiodarone Amiodarone inhibits the reaction [Triiodothyronine results in decreased expression of ADRB3 protein]decreases expression|decreases reaction 10217540
D000643 Ammonium Chloride Ammonium Chloride affects the expression of ADRB3 mRNAaffects expression 16483693
D001104 Arbutin Arbutin results in decreased expression of ADRB3 mRNAdecreases expression 17103032
C015001 arsenite arsenite results in decreased expression of ADRB3 mRNAdecreases expression 18191166
D019324 beta-Naphthoflavone [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of ADRB3 mRNAaffects cotreatment|decreases expression 18164116
C039248 BRL 26830A BRL 26830A binds to and results in increased activity of ADRB3 proteinaffects binding|increases activity 7520314
C057368 BRL 37344 BRL 37344 binds to and results in increased activity of ADRB3 proteinaffects binding|increases activity 1682311
C057368 BRL 37344 BRL 37344 results in increased activity of ADRB3 proteinincreases activity 17622774
C057368 BRL 37344 BRL 37344 binds to and results in increased activity of ADRB3 proteinaffects binding|increases activity 17622774
C045916 broxaterol broxaterol binds to and results in increased activity of ADRB3 proteinaffects binding|increases activity 16648137
D002087 Butyrates Butyrates results in decreased expression of ADRB3 mRNAdecreases expression 8120022
D002087 Butyrates Butyrates results in decreased expression of ADRB3 proteindecreases expression 8120022
C033394 CGP 12177 CGP 12177 binds to and results in increased activity of ADRB3 proteinaffects binding|increases activity 15563584
10952688
11753577
C033394 CGP 12177 3-(2-ethylphenoxy)-1-(1,2,3,4-tetrahydronaphth-1-ylamino)-2-propanol oxalate inhibits the reaction [CGP 12177 results in increased activity of ADRB3 protein]decreases reaction|increases activity 8569714
C033394 CGP 12177 CGP 12177 binds to ADRB3 proteinaffects binding 10217540
C033394 CGP 12177 CGP 12177 binds to and results in increased activity of ADRB3 proteinaffects binding|increases activity 7815362
C033394 CGP 12177 CGP 12177 results in increased activity of ADRB3 proteinincreases activity 8569714
C049763 CGP 20712A CGP 20712A binds to and results in increased activity of ADRB3 proteinaffects binding|increases activity 1682311
D004390 Chlorpyrifos Chlorpyrifos affects the expression of ADRB3 mRNAaffects expression 18812211
D004390 Chlorpyrifos Chlorpyrifos results in decreased expression of ADRB3 mRNAdecreases expression 17452286
C076126 CL 316243 [3-(2-ethylphenoxy)-1-(1,2,3,4-tetrahydronaphth-1-ylamino)-2-propanol oxalate results in increased expression of ADRB3 mRNA] which results in increased susceptibility to CL 316243increases expression|increases response to substance 10725275
C076126 CL 316243 CL 316243 binds to and results in increased activity of ADRB3 proteinaffects binding|increases activity 16399693
C076126 CL 316243 CL 316243 binds to and results in increased activity of ADRB3 proteinaffects binding|increases activity 11275008
7815362
D002976 Clenbuterol Clenbuterol binds to and results in increased activity of ADRB3 proteinaffects binding|increases activity 7815362
C047975 cyanopindolol 3-(2-ethylphenoxy)-1-(1,2,3,4-tetrahydronaphth-1-ylamino)-2-propanol oxalate inhibits the reaction [cyanopindolol binds to ADRB3 protein]affects binding|decreases reaction 10344530
C047975 cyanopindolol cyanopindolol binds to ADRB3 proteinaffects binding 10344530
D003907 Dexamethasone Dexamethasone results in decreased expression of ADRB3 mRNAdecreases expression 10725275
D003976 Diazinon Diazinon affects the expression of ADRB3 mRNAaffects expression 18812211
D003976 Diazinon Diazinon results in decreased expression of ADRB3 mRNAdecreases expression 17452286
D004041 Dietary Fats Dietary Fats results in decreased expression of ADRB3 mRNAdecreases expression 18042831
20132043
D004041 Dietary Fats Plant Extracts inhibits the reaction [Dietary Fats results in decreased expression of ADRB3 mRNA]decreases expression|decreases reaction 20132043
D004041 Dietary Fats Dietary Fats results in increased expression of ADRB3 mRNAincreases expression 18721800
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of ADRB3 mRNAaffects cotreatment|decreases expression 18164116
D004280 Dobutamine [Dobutamine co-treated with ICI 118551] results in increased expression of ADRB3 mRNAaffects cotreatment|increases expression 19719783
D004280 Dobutamine [Dobutamine co-treated with ICI 118551] results in increased expression of ADRB3 proteinaffects cotreatment|increases expression 19719783
D004837 Epinephrine Epinephrine binds to and results in increased activity of ADRB3 proteinaffects binding|increases activity 1682311
D004837 Epinephrine Epinephrine binds to and results in increased activity of ADRB3 proteinaffects binding|increases activity 7815362
D004958 Estradiol Estradiol results in increased expression of ADRB3 mRNAincreases expression 15713686
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of ADRB3 mRNAincreases expression 15212814
D005419 Flavonoids Flavonoids results in increased expression of ADRB3 mRNAincreases expression 18035473
D005576 Forskolin Forskolin results in decreased expression of ADRB3 mRNAdecreases expression 10725275
C026777 ICI 118551 ICI 118551 binds to and results in increased activity of ADRB3 proteinaffects binding|increases activity 1682311
C026777 ICI 118551 [Dobutamine co-treated with ICI 118551] results in increased expression of ADRB3 mRNAaffects cotreatment|increases expression 19719783
C026777 ICI 118551 [Dobutamine co-treated with ICI 118551] results in increased expression of ADRB3 proteinaffects cotreatment|increases expression 19719783
C071909 ICI D7114 3-(2-ethylphenoxy)-1-(1,2,3,4-tetrahydronaphth-1-ylamino)-2-propanol oxalate inhibits the reaction [ICI D7114 binds to and results in increased activity of ADRB3 protein]affects binding|decreases reaction|increases activity 12606629
C071909 ICI D7114 ICI D7114 binds to and results in increased activity of ADRB3 proteinaffects binding|increases activity 12606629
D007545 Isoproterenol Isoproterenol binds to and results in increased activity of ADRB3 proteinaffects binding|increases activity 1682311
D007545 Isoproterenol Isoproterenol results in increased activity of ADRB3 proteinincreases activity 18820136
D007545 Isoproterenol L 748,337 inhibits the reaction [Isoproterenol results in increased activity of ADRB3 protein]decreases reaction|increases activity 18820136
D007545 Isoproterenol 3-(2-ethylphenoxy)-1-(1,2,3,4-tetrahydronaphth-1-ylamino)-2-propanol oxalate inhibits the reaction [Isoproterenol results in increased activity of ADRB3 protein]decreases reaction|increases activity 17622774
D007545 Isoproterenol Isoproterenol binds to and results in increased activity of ADRB3 proteinaffects binding|increases activity 7815362
D007545 Isoproterenol Isoproterenol results in increased activity of ADRB3 proteinincreases activity 17622774
C011890 kojic acid kojic acid results in decreased expression of ADRB3 mRNAdecreases expression 16595896
C120576 L 748,337 L 748,337 binds to and results in decreased activity of ADRB3 proteinaffects binding|decreases activity 16022967
C120576 L 748,337 L 748,337 inhibits the reaction [Isoproterenol results in increased activity of ADRB3 protein]decreases reaction|increases activity 18820136
C120576 L 748,337 L 748,337 binds to and results in decreased activity of ADRB3 proteinaffects binding|decreases activity 18820136
D009638 Norepinephrine Norepinephrine binds to and results in increased activity of ADRB3 proteinaffects binding|increases activity 1682311
D009638 Norepinephrine Octopamine inhibits the reaction [Norepinephrine binds to ADRB3 protein]affects binding|decreases reaction 10344530
D009638 Norepinephrine 3-(2-ethylphenoxy)-1-(1,2,3,4-tetrahydronaphth-1-ylamino)-2-propanol oxalate inhibits the reaction [Norepinephrine results in increased activity of ADRB3 protein]decreases reaction|increases activity 17622774
8569714
D009638 Norepinephrine Norepinephrine binds to and results in increased activity of ADRB3 proteinaffects binding|increases activity 7815362
D009638 Norepinephrine Norepinephrine results in increased activity of ADRB3 proteinincreases activity 17622774
8569714
D009655 Octopamine Octopamine results in increased activity of ADRB3 proteinincreases activity 10344530
D009655 Octopamine Octopamine inhibits the reaction [Norepinephrine binds to ADRB3 protein]affects binding|decreases reaction 10344530
D009655 Octopamine Octopamine results in increased activity of ADRB3 proteinincreases activity 10344530
D010096 Oxprenolol Oxprenolol binds to and results in increased activity of ADRB3 proteinaffects binding|increases activity 1682311
D010126 Ozone Ozone results in decreased expression of ADRB3 mRNAdecreases expression 17460151
12763052
C041786 palm oil palm oil results in decreased expression of ADRB3 mRNAdecreases expression 18042831
D010656 Phenylephrine ADRB3 protein results in increased susceptibility to Phenylephrineincreases response to substance 16022967
D010656 Phenylephrine SR 58611A inhibits the reaction [ADRB3 protein results in increased susceptibility to Phenylephrine]decreases reaction|increases response to substance 16022967
D010869 Pindolol Pindolol binds to and results in increased activity of ADRB3 proteinaffects binding|increases activity 1682311
D010869 Pindolol Pindolol binds to and results in increased activity of ADRB3 proteinaffects binding|increases activity 7815362
C006253 pirinixic acid pirinixic acid results in decreased expression of ADRB3 mRNAdecreases expression 17950772
C006253 pirinixic acid pirinixic acid results in increased expression of ADRB3 mRNAincreases expression 16306350
C006253 pirinixic acid PPARA protein promotes the reaction [pirinixic acid results in decreased expression of ADRB3 mRNA]decreases expression|increases reaction 17950772
D010936 Plant Extracts Plant Extracts inhibits the reaction [Dietary Fats results in decreased expression of ADRB3 mRNA]decreases expression|decreases reaction 20132043
D011374 Progesterone Progesterone results in increased expression of ADRB3 mRNAincreases expression 15713686
C089730 rosiglitazone rosiglitazone results in decreased expression of ADRB3 mRNAdecreases expression 16306350
C076252 SR 58611A SR 58611A binds to and results in increased activity of ADRB3 proteinaffects binding|increases activity 16022967
C076252 SR 58611A SR 58611A inhibits the reaction [ADRB3 protein results in increased susceptibility to Phenylephrine]decreases reaction|increases response to substance 16022967
C076252 SR 58611A 3-(2-ethylphenoxy)-1-(1,2,3,4-tetrahydronaphth-1-ylamino)-2-propanol oxalate inhibits the reaction [SR 58611A results in increased activity of ADRB3 protein]decreases reaction|increases activity 8569714
C076252 SR 58611A SR 58611A binds to and results in increased activity of ADRB3 proteinaffects binding|increases activity 9718277
12208771
C076252 SR 58611A SR 58611A results in increased activity of ADRB3 proteinincreases activity 8569714
C114929 SR 59104A SR 59104A binds to and results in increased activity of ADRB3 proteinaffects binding|increases activity 10952688
C114930 SR 59119A 3-(2-ethylphenoxy)-1-(1,2,3,4-tetrahydronaphth-1-ylamino)-2-propanol oxalate inhibits the reaction [[SR 59119A binds to and results in increased activity of ADRB3 protein] which results in increased abundance of Cyclic AMP]affects binding|decreases reaction|increases abundance|increases activity 10952688
C114930 SR 59119A SR 59119A binds to and results in increased activity of ADRB3 proteinaffects binding|increases activity 10952688
C114930 SR 59119A [SR 59119A binds to and results in increased activity of ADRB3 protein] which results in increased abundance of Cyclic AMPaffects binding|increases abundance|increases activity 10952688
D014284 Triiodothyronine Amiodarone inhibits the reaction [Triiodothyronine results in decreased expression of ADRB3 protein]decreases expression|decreases reaction 10217540
D014284 Triiodothyronine Triiodothyronine results in decreased expression of ADRB3 mRNAdecreases expression 10217540
D014284 Triiodothyronine Triiodothyronine results in decreased expression of ADRB3 proteindecreases expression 10217540
D014284 Triiodothyronine Triiodothyronine results in increased expression of ADRB3 proteinincreases expression 8836703
D013726 Terbutaline Terbutaline binds to and results in increased activity of ADRB3 proteinaffects binding|increases activity 16648137
D013726 Terbutaline Terbutaline binds to and results in increased activity of ADRB3 proteinaffects binding|increases activity 7815362
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Terbutaline 4.4114610225
MESH:D000138 Acidosis Ammonium Chloride 3.0418287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.4117505938
MESH:D055371 Acute Lung Injury pirinixic acid 2.6418653653
MESH:D000230 Adenocarcinoma Estradiol 3.6911473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 3.6914692618
MESH:D000236 Adenoma beta-Naphthoflavone 5.8219389873
MESH:D000236 Adenoma Diethylnitrosamine 5.8210737359 6695378
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 8.3718056438 19052882 17620307 16434500 17162532 19061943
MESH:D018248 Adenoma, Liver Cell pirinixic acid 8.3716434500
MESH:D000382 Agricultural Workers' Diseases Chlorpyrifos 7.4716611668 17119214 11874814
MESH:D000382 Agricultural Workers' Diseases Diazinon 7.4716487989
MESH:D000544 Alzheimer Disease Ozone 5.9515513908
MESH:D000544 Alzheimer Disease Plant Extracts 5.9516962711
MESH:D000544 Alzheimer Disease rosiglitazone 5.9519621015
MESH:D000686 Amyloidosis Terbutaline 5.137986221
MESH:D000799 Angioedema Acetaminophen 3.3210982225
MESH:D001145 Arrhythmias, Cardiac Amiodarone 7.6518057881 18218290 20041841
MESH:D001145 Arrhythmias, Cardiac Phenylephrine 7.6517460149
MESH:D001161 Arteriosclerosis Dietary Fats 8.2315238619
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 8.2311256880
MESH:D001169 Arthritis, Experimental Dexamethasone 10.4517659584
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 10.4515885639
MESH:D001169 Arthritis, Experimental Plant Extracts 10.4514686799
MESH:D001172 Arthritis, Rheumatoid Ozone 2.4215570426
MESH:D001249 Asthma Ozone 2.4717854713 16373670
MESH:D001281 Atrial Fibrillation Amiodarone 3.5119698954 18651412
MESH:D001321 Autistic Disorder Acetaminophen 2.3718445737
MESH:D001321 Autistic Disorder Norepinephrine 2.378570775
MESH:D001321 Autistic Disorder Terbutaline 2.3717400887 16417856
MESH:D001778 Blood Coagulation Disorders Amiodarone 7.5419483382
MESH:D001778 Blood Coagulation Disorders pirinixic acid 7.5419483382
MESH:D001919 Bradycardia Isoproterenol 9.246740701
MESH:D001919 Bradycardia Phenylephrine 9.2415306635
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 4.8117868700
MESH:D001930 Brain Injuries Progesterone 3.7515380490 15665606 15845082
MESH:D002545 Brain Ischemia Plant Extracts 4.2116041641
MESH:D001943 Breast Neoplasms Dietary Fats 1.8820435547
MESH:D001943 Breast Neoplasms Diethylnitrosamine 1.8817474063
MESH:D001943 Breast Neoplasms Estradiol 1.8816675129 17289903 19861407 18497071 17261762 12948864 17018787 14630087
MESH:D001943 Breast Neoplasms Progesterone 1.8816175315 15562024 17614352
MESH:D016535 Bronchial Hyperreactivity Ozone 3.2717626835 15516495 19059883 16777450 14754758 18315731 18417511
MESH:D002057 Burns, Chemical Plant Extracts 4.819625245
MESH:D002100 Cachexia Ozone 4.2216183385
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 3.9416111702
MESH:D019559 Capillary Leak Syndrome Terbutaline 5.339428835 11713377
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 5.723084413
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 5.7216681979 20514400 18691550 20727157 18971187 16569478 11831363 16878318 16779866 16540662 18665156 18788625 10737359 16698587 19418558 16502159 19822196 16328049 20512989 19171122 20007298 17173139 17162532 19539802 20101231 19919837 19383236 16935385 19107877 17055752 3581430 16830150 19335982 18978308 20432363 19208518 18494052 10672840 18056438 16288022 21159647 17138121 19394651 20214788 18393292 19519916 18506893 19052882 18210153 20524982 20935162 17978847 18785209 3084413 19701751 17761372 17428255 20084675 16807293
MESH:D006528 Carcinoma, Hepatocellular Estradiol 5.7216924424
MESH:D006528 Carcinoma, Hepatocellular Plant Extracts 5.7218834353
MESH:D006332 Cardiomegaly Isoproterenol 13.9911179087 7544033
MESH:D006332 Cardiomegaly Norepinephrine 13.9911179087
MESH:D006332 Cardiomegaly Phenylephrine 13.9916170337 17124262 17287366 15728586 11179087 11754973
MESH:D006332 Cardiomegaly Plant Extracts 13.9917645561
MESH:D002311 Cardiomyopathy, Dilated Amiodarone 2.6915710769 19225199
MESH:D002341 Carotid Artery Thrombosis Amiodarone 4.5618974383
MESH:D002375 Catalepsy Norepinephrine 5.028216760
MESH:D002386 Cataract Acetaminophen 2.2610977129
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 5.482727394 7505956 17174075 21159647
MESH:D002471 Cell Transformation, Neoplastic Estradiol 5.4818566989
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 3.2519052882
MESH:D002779 Cholestasis Ethinyl Estradiol 6.4516105132 17333356 11677210 15861022 16919318 17110522 17681005
MESH:D002779 Cholestasis pirinixic acid 6.4519176532
MESH:D003110 Colonic Neoplasms arsenite 5.3315037631
MESH:D003110 Colonic Neoplasms Butyrates 5.3315936596
MESH:D003110 Colonic Neoplasms Dexamethasone 5.3315824018
MESH:D003371 Cough Terbutaline 5.0419679606
MESH:D019465 Craniofacial Abnormalities Dexamethasone 2.2617728286
MESH:D017449 Dermatitis, Allergic Contact Dexamethasone 2.9312438553
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.1718249437
MESH:D003920 Diabetes Mellitus rosiglitazone 3.8617446233
MESH:D003921 Diabetes Mellitus, Experimental marker/mechanism 17622774
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 4.1720387270
MESH:D003924 Diabetes Mellitus, Type 2 rosiglitazone 4.1712642470
MESH:D003928 Diabetic Nephropathies Estradiol 7.7319279558
MESH:D003928 Diabetic Nephropathies Plant Extracts 7.7319706694
MESH:D003929 Diabetic Neuropathies Progesterone 3.9917187935
MESH:D003967 Diarrhea Dexamethasone 3.227237001
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 5.1911743745 16485898 14550746 15619225 12594235 19164858 12153990 19923254 19420014 15968718 18713872 11421492 11739529 17562736 10915739 2444490 12540782 16393943 10663392 17522070 11529661 12392966 19739265 10774834 11287661 19370779 17906064 19085960 14986274 19416960 18071297 11461765 11834606 16227642 14725611 16781746 16081117 12958197 12705907 16109766 16177239
MESH:D056486 Drug-Induced Liver Injury Amiodarone 5.1918218290 15265979
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 5.1919107877
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.5719426721
MESH:D050171 Dyslipidemias Dietary Fats 3.0718367378
MESH:D004417 Dyspnea Diazinon 4.2816487989
MESH:D004485 Eczema Dexamethasone 3.9712438553
MESH:D004487 Edema Dexamethasone 12.7819703484
MESH:D004487 Edema pirinixic acid 12.7812083418
MESH:D004487 Edema Plant Extracts 12.7812787963
MESH:D004487 Edema rosiglitazone 12.7812083418
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 7.4112538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 7.4117692515
MESH:D016889 Endometrial Neoplasms Estradiol 2.6311473722 18566989 19148513
MESH:D004715 Endometriosis Progesterone 3.3216134523
MESH:D004719 Endomyocardial Fibrosis Plant Extracts 5.1515268973
MESH:D004827 Epilepsy Epinephrine 9.87821787
MESH:D004827 Epilepsy Norepinephrine 9.87821787
MESH:D004827 Epilepsy Plant Extracts 9.8719439326 19700373
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 4.5916302075
MESH:D005234 Fatty Liver Amiodarone 35.2114986274
MESH:D005234 Fatty Liver arsenite 35.2118296743
MESH:D005234 Fatty Liver Dietary Fats 35.2118296743 17967931 19004024 19551842
MESH:D005234 Fatty Liver Diethylnitrosamine 35.2121071580 20387270
MESH:D005234 Fatty Liver Ethinyl Estradiol 35.2115345470
MESH:D005234 Fatty Liver pirinixic acid 35.2119236843 20131406
MESH:D005234 Fatty Liver Plant Extracts 35.2115975614
MESH:D005234 Fatty Liver rosiglitazone 35.2119196556
MESH:D005355 Fibrosis arsenite 12.2118296743
MESH:D005355 Fibrosis Dietary Fats 12.2118296743
MESH:D005355 Fibrosis Terbutaline 12.2115467267
MESH:D005756 Gastritis Acetaminophen 3.1516983495
MESH:D006333 Heart Failure Dobutamine 14.2717440445
MESH:D006333 Heart Failure Isoproterenol 14.2718097624
MESH:D006333 Heart Failure pirinixic acid 14.2720558911
MESH:D006333 Heart Failure Plant Extracts 14.2718097624
MESH:D006505 Hepatitis Diazinon 4.0916487989
MESH:D006529 Hepatomegaly Amiodarone 6.9115265979
MESH:D006529 Hepatomegaly pirinixic acid 6.9116221962 19772884 19176532 18467677
MESH:D006548 Hernia, Diaphragmatic Dexamethasone 2.877520565
MESH:D006558 Herpes Genitalis Estradiol 4.5015709030
MESH:D006561 Herpes Simplex Plant Extracts 4.1110715843
MESH:D015658 HIV Infections Plant Extracts 3.4012878215
MESH:D019584 Hot Flashes Estradiol 8.5817088409
MESH:D019584 Hot Flashes Plant Extracts 8.5816566672 14716179 17454163
MESH:D006930 Hyperalgesia Acetaminophen 6.5216870215
MESH:D006930 Hyperalgesia rosiglitazone 6.5212083418
MESH:D006937 Hypercholesterolemia Amiodarone 7.638137927 9751232
MESH:D006937 Hypercholesterolemia Dietary Fats 7.6321332399
MESH:D006943 Hyperglycemia pirinixic acid 2.7320558911
MESH:D020138 Hyperhomocysteinemia Plant Extracts 4.0316484555
MESH:D006949 Hyperlipidemias marker/mechanism 16027735
MESH:D006949 Hyperlipidemias Dietary Fats 7.8721332399
MESH:D006949 Hyperlipidemias Plant Extracts 7.8715268973 15975614
MESH:D006973 Hypertension Dexamethasone 4.9417042910
MESH:D006973 Hypertension Phenylephrine 4.9412717712 8949925
MESH:D006984 Hypertrophy Isoproterenol 9.4512791704
MESH:D006984 Hypertrophy Phenylephrine 9.4512791704 18502941
MESH:D006985 Hyperventilation Terbutaline 5.5610895896
MESH:D007008 Hypokalemia Terbutaline 5.5717292646
MESH:D007021 Hypospadias Ethinyl Estradiol 3.3016945680 16569931
MESH:D007022 Hypotension Epinephrine 12.936740701
MESH:D007022 Hypotension Isoproterenol 12.936740701
MESH:D007022 Hypotension Norepinephrine 12.936740701
MESH:D007037 Hypothyroidism Amiodarone 4.0117991464 18020914
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 3.9015869954
MESH:D007247 Infertility, Female Ethinyl Estradiol 2.9812013081
MESH:D007248 Infertility, Male Diazinon 5.7612948887 16466525
MESH:D007248 Infertility, Male Ethinyl Estradiol 5.7617937319
MESH:D007249 Inflammation Dexamethasone 19.7711099482 8960868
MESH:D007249 Inflammation Dietary Fats 19.7720412841
MESH:D007249 Inflammation Diethylnitrosamine 19.7718785209
MESH:D007249 Inflammation Flavonoids 19.7717296493
MESH:D007249 Inflammation Plant Extracts 19.7716366677 19332304 15997105 12787963
MESH:D007249 Inflammation Progesterone 19.7715869954
MESH:D007249 Inflammation rosiglitazone 19.7712083418
MESH:D007333 Insulin Resistance Dietary Fats 14.7811836018 18457598
MESH:D007333 Insulin Resistance Estradiol 14.7816393666 16627594
MESH:D007333 Insulin Resistance pirinixic acid 14.7816306350
MESH:D007333 Insulin Resistance rosiglitazone 14.7816306350
MESH:D007414 Intestinal Neoplasms Plant Extracts 4.1712584176 12628509 12351151
MESH:D007674 Kidney Diseases Acetaminophen 4.8415629191 12587719
MESH:D007674 Kidney Diseases Estradiol 4.8415618244
MESH:D007680 Kidney Neoplasms Estradiol 2.5715610895
MESH:D053609 Lethargy Terbutaline 5.7910895896
MESH:D008064 Lipidoses Amiodarone 3.1315342952 17567588
MESH:D008103 Liver Cirrhosis arsenite 13.3118296743
MESH:D008103 Liver Cirrhosis Dietary Fats 13.3118296743
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 13.3118522880 20032147 18407596 18665156 19638242
MESH:D008103 Liver Cirrhosis Plant Extracts 13.3117157831
MESH:D008106 Liver Cirrhosis, Experimental Dexamethasone 5.8816718785
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 5.8814659978 14716833
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 5.8815474484
MESH:D008106 Liver Cirrhosis, Experimental Plant Extracts 5.8815479170
MESH:D008106 Liver Cirrhosis, Experimental rosiglitazone 5.8817347453 15980055
MESH:D008107 Liver Diseases Acetaminophen 8.0916611625 19784758 19014921 12587719 19460945 16610002 12969438 11587558
MESH:D008107 Liver Diseases Chlorpyrifos 8.0915991261
MESH:D008107 Liver Diseases Diethylnitrosamine 8.0917034775
MESH:D008107 Liver Diseases Plant Extracts 8.0917034775
MESH:D017114 Liver Failure, Acute Acetaminophen 2.7916871587 17185352
MESH:D008113 Liver Neoplasms beta-Naphthoflavone 8.9119389873 21295105
MESH:D008113 Liver Neoplasms Diethylnitrosamine 8.9121071580 2422723 12771043 19090486 19690152 19073162 20101389 20434301 19642983 19850985 19294768 19551842 19996281 16942905 2862719 19833225 19255062 20501860 12112319 20118626 20583210 19427195 19254457 18978307 20137499 21047994 18977376 15885732 18648771 19256749 15175105 20405173 21167192 9163691 10737359 21278145 20492335 19812893 20452335 19638242 19426721 18644402 19499222 18754104
MESH:D008113 Liver Neoplasms pirinixic acid 8.9116377806 20007298 15890375
MESH:D008113 Liver Neoplasms Plant Extracts 8.9119168119
MESH:D008114 Liver Neoplasms, Experimental beta-Naphthoflavone 8.0718164116
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 8.0716842330 17942915 18308698 18253720 19519916 18079962 19009564 18164116 19539802 18544905 18282651 18775883 9362446 19004024 16267830 18093689 17854601 2563599 19126423 17174075 21159647 3124819
MESH:D008114 Liver Neoplasms, Experimental kojic acid 8.0718544905
MESH:D008133 Long QT Syndrome Amiodarone 7.3811989578 15350150 17391786
MESH:D008133 Long QT Syndrome Dobutamine 7.3819353679
MESH:D008171 Lung Diseases Amiodarone 10.4912587719
MESH:D008171 Lung Diseases Dobutamine 10.4916638327
MESH:D008171 Lung Diseases Ozone 10.4919066396 8266340
MESH:D017563 Lung Diseases, Interstitial Amiodarone 3.9518516814
MESH:D055370 Lung Injury Ozone 3.3520417186
MESH:D008175 Lung Neoplasms arsenite 5.7616809336
MESH:D008175 Lung Neoplasms Dexamethasone 5.7611195469 15824018
MESH:D008175 Lung Neoplasms Diethylnitrosamine 5.7620512841 20970405 6695378 21163286
MESH:D008175 Lung Neoplasms Ozone 5.767614698 8597069
MESH:D008175 Lung Neoplasms Plant Extracts 5.7620869020
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 8.0711408345 11807958 17203775 16891317
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 8.0711408345 17203775
MESH:D008325 Mammary Neoplasms, Experimental rosiglitazone 8.0716827153
MESH:D020149 Manganese Poisoning Estradiol 3.9519453300
MESH:D008546 Melanoma, Experimental Acetaminophen 3.0619513568
MESH:D024821 Metabolic Syndrome X rosiglitazone 3.9517261469
MESH:D008679 Metaplasia Ozone 4.5810496685
MESH:D020326 Migraine without Aura Cyclic AMP 4.6611304026
MESH:D009101 Multiple Myeloma Dexamethasone 3.1316118317 15867202 15744524
MESH:D009135 Muscular Diseases pirinixic acid 3.0016239165
MESH:D009181 Mycoses Amiodarone 4.3712754197 17974566
MESH:D009190 Myelodysplastic Syndromes Dexamethasone 3.239809623
MESH:D009203 Myocardial Infarction Isoproterenol 5.2417052832 16697266 19595682 15740881 16584858 16538859 19172585
MESH:D009203 Myocardial Infarction pirinixic acid 5.2419151258
MESH:D017202 Myocardial Ischemia Dobutamine 4.6212447174
MESH:D015428 Myocardial Reperfusion Injury Estradiol 12.0016810080
MESH:D015428 Myocardial Reperfusion Injury Norepinephrine 12.0015642760
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 12.0016411023
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 2.349029167 3581430
MESH:D009369 Neoplasms pirinixic acid 1.7017405874
MESH:D009389 Neovascularization, Pathologic arsenite 8.4315738583
MESH:D009389 Neovascularization, Pathologic Estradiol 8.4317289903
MESH:D009421 Nervous System Malformations Estradiol 3.1616427766 11399458
MESH:D019954 Neurobehavioral Manifestations Plant Extracts 4.6817168769
MESH:D019636 Neurodegenerative Diseases Acetaminophen 6.7718514411
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 6.7720387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 4.5920387270
MESH:D020258 Neurotoxicity Syndromes Chlorpyrifos 3.8115081274
MESH:D009765 Obesity marker/mechanism
MESH:D009765 Obesity Dietary Fats 6.5621332399 18457598 19632207 16723640 20518802 11836018 17217161 18674790 20132043
MESH:D009765 Obesity pirinixic acid 6.5620558911
MESH:D009765 Obesity Plant Extracts 6.5619056576 20132043
MESH:D007752 Obstetric Labor, Premature Terbutaline 5.5814998686
MESH:D010051 Ovarian Neoplasms Estradiol 4.2419401270
MESH:D010051 Ovarian Neoplasms Progesterone 4.2416525653 17393432
MESH:D010146 Pain Acetaminophen 1.9916870215
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 2.2216540662
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.2111578682
MESH:D010212 Papilloma Plant Extracts 3.9915173996 16517061
MESH:D010538 Peritonitis Ozone 3.6316369182
MESH:D011014 Pneumonia Ozone 3.8818007984 18929643 18381685
MESH:D011041 Poisoning Diazinon 3.8817603234
MESH:D011230 Precancerous Conditions Diethylnitrosamine 3.122563599
MESH:D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma Dexamethasone 3.2421297632
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.4220887781
MESH:D011471 Prostatic Neoplasms Estradiol 3.7616740699
MESH:D011471 Prostatic Neoplasms Plant Extracts 3.7614666653 17804756
MESH:D011537 Pruritus Ethinyl Estradiol 2.8015861022 16919318
MESH:D011654 Pulmonary Edema Isoproterenol 9.7610903255
MESH:D011654 Pulmonary Edema Terbutaline 9.7610903255
MESH:D011658 Pulmonary Fibrosis Amiodarone 2.6412832656 12490602 11597910
MESH:D015427 Reperfusion Injury pirinixic acid 2.1119058328
MESH:D012128 Respiratory Distress Syndrome, Adult Dexamethasone 8.1011700416 18379247
MESH:D012128 Respiratory Distress Syndrome, Adult Terbutaline 8.102878809
MESH:D012135 Respiratory Sounds Chlorpyrifos 4.1311874814 17119214 16611668
MESH:D012140 Respiratory Tract Diseases Chlorpyrifos 4.3717119214 16611668
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.6518045962
MESH:D012729 Sex Chromosome Aberrations Chlorpyrifos 5.566418539
MESH:D012772 Shock, Septic Terbutaline 4.983431524
OMIM:609620 SHORT QT SYNDROME 1 Amiodarone 4.5618724381
MESH:D012852 Sinusitis Phenylephrine 4.197327846
MESH:D012878 Skin Neoplasms Plant Extracts 3.2216517061 15173996
MESH:D013088 Spermatocele Ethinyl Estradiol 3.4116709447
MESH:D013119 Spinal Cord Injuries Progesterone 3.7616503802 15862959
MESH:D013272 Stomach Diseases Dexamethasone 3.8115472012
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 1.7518456281
MESH:D013276 Stomach Ulcer Amiodarone 9.5618087811
MESH:D013276 Stomach Ulcer Dexamethasone 9.5615138204
MESH:D013276 Stomach Ulcer Plant Extracts 9.5618237397 17135157 18193104 12787963 15255614
MESH:D013610 Tachycardia Amiodarone 15.3811238279
MESH:D013610 Tachycardia Norepinephrine 15.383261545
MESH:D013610 Tachycardia Terbutaline 15.3810895896
MESH:D017180 Tachycardia, Ventricular Amiodarone 3.7019225199
MESH:D013705 Temporomandibular Joint Disorders Plant Extracts 4.9517997062
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.1411994571
MESH:D013927 Thrombosis Ethinyl Estradiol 2.7215669648
MESH:D013959 Thyroid Diseases Amiodarone 4.2319731979
MESH:D013964 Thyroid Neoplasms Butyrates 6.2417967635
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 6.247505956
MESH:D013971 Thyrotoxicosis Amiodarone 4.3518020914 19584973
MESH:D013978 Tibial Fractures Estradiol 4.1619048282
MESH:D016171 Torsades de Pointes Amiodarone 9.0511989578 17467628
MESH:D016171 Torsades de Pointes Dobutamine 9.0519353679
MESH:D014570 Urologic Diseases Diazinon 4.7516487989
MESH:D014581 Urticaria Acetaminophen 2.5010982225
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 2.8114692618
MESH:D014605 Uveitis Dexamethasone 4.291336536
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.0714671159 15869587
MESH:D018487 Ventricular Dysfunction, Left Isoproterenol 9.1618097624
MESH:D018487 Ventricular Dysfunction, Left Plant Extracts 9.1618097624
MESH:D020257 Ventricular Remodeling Isoproterenol 11.1418097624
MESH:D020257 Ventricular Remodeling Plant Extracts 11.1418097624
MESH:D015430 Weight Gain Dietary Fats 3.3016723640
MESH:D014947 Wounds and Injuries Plant Extracts 3.8320213670 19894650
Pathway ID Pathway Name
KEGG:04020 Calcium signaling pathway
KEGG:04144 Endocytosis
KEGG:04080 Neuroactive ligand-receptor interaction
KEGG:04970 Salivary secretion
REACT:14797 Signaling by GPCR
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA24598
    • Releated gene ID Related gene Name
    PA24598ADRB3
    Releated disease ID Related disease Name
    PA447306diabetes mellitus type 2 and obesity
    PA443890Diabetes Mellitus, Type 2
    PA128406954Weight gain
    PA444370Heart Failure
    Releated drug ID Related drug Name
    PA450688olanzapine
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB00368 agonist Norepinephrine Vasoconstrictor Agents;Sympathomimetics;Adrenergic alpha-Agonists
    DB00571 antagonist Propranolol Anti-anxiety Agents;Antihypertensive Agents;Adrenergic Agents;Adrenergic beta-Antagonists;Vasodilator Agents;Antiarrhythmic Agents;Anti-Arrhythmia Agents
    DB01064 agonist Isoproterenol Sympathomimetics;Bronchodilator Agents;Adrenergic beta-Agonists;Cardiotonic Agents;Sympathomimetic
    DB01102 agonist Arbutamine Adrenergic beta-Agonists;Cardiotonic Agents
    DB01288 agonist Duovent UDV Sympathomimetics;Bronchodilator Agents;Adrenergic beta-Agonists;Tocolytic Agents
    DB01363 agonist Tartephedreel
    DB01407 agonist Clenbuterol Sympathomimetics;Bronchodilator Agents;Adrenergic beta-Agonists
    DB06262 agonist Droxidopa Vasoconstrictor Agents;Sympathomimetics;Adrenergic alpha-Agonists
    DB08807 - Bopindolol Antihypertensive Agents;Adrenergic beta-Antagonists
    DB08808 antagonist Bupranolol Antihypertensive Agents;Adrenergic beta-Antagonists;Anti-Arrhythmia Agents
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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