AutismKB 2.0

Annotation Detail for CYP3A7


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Basic Information Top
Gene Symbol:CYP3A7 ( CP37,P450-HFLA )
Gene Full Name: cytochrome P450, family 3, subfamily A, polypeptide 7
Band: 7q22.1
Quick LinksEntrez ID:1551; OMIM: 605340; Uniprot ID:CP3A7_HUMAN; ENSEMBL ID: ENSG00000160870; HGNC ID: 2640
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa00830Retinol metabolism
hsa00140Steroid hormone biosynthesis
hsa00980Metabolism of xenobiotics by cytochrome P450
hsa00982Drug metabolism - cytochrome P450
hsa00983Drug metabolism - other enzymes
hsa01100Metabolic pathways
hsa00591Linoleic acid metabolism
Pathway IDPathway Name
Biological oxidations
No data
No data
Pathway IDPathway Name
500197Xenobiotics
Related Diseases/Disorders Top
No data
Desease IDDesease Name
2102Polycystic ovary syndrome
Desease Name
bone density dehydroepiandrosterone sulphate osteoporosis
METABOLIC
enzyme activity
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C035342 1,4-naphthoquinone CYP3A7 protein results in increased abundance of 1,4-naphthoquinoneincreases abundance 16243959
C029350 1-naphthol CYP3A7 protein results in increased abundance of 1-naphtholincreases abundance 16243959
C002202 4-oxoretinoic acid 4-oxoretinoic acid results in decreased expression of CYP3A7 mRNAdecreases expression 15982314
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of CYP3A7 proteinaffects expression 20106945
D015760 Alfentanil CYP3A7 protein affects the metabolism of Alfentanilaffects metabolic processing 15557344
C103303 alitretinoin alitretinoin results in decreased expression of CYP3A7 mRNAdecreases expression 15982314
D002220 Carbamazepine Carbamazepine results in increased expression of CYP3A7 mRNAincreases expression 17112801
D020111 Chlorodiphenyl (54% Chlorine) Chlorodiphenyl (54% Chlorine) results in increased expression of CYP3A7 mRNAincreases expression 17851650
D004390 Chlorpyrifos CYP3A7 protein affects the metabolism of Chlorpyrifosaffects metabolic processing 17110060
17079358
D003022 Clotrimazole Clotrimazole results in increased expression of CYP3A7 mRNAincreases expression 12673034
D016572 Cyclosporine Cyclosporine results in decreased expression of CYP3A7 mRNAdecreases expression 20106945
D016572 Cyclosporine Cyclosporine results in increased expression of CYP3A7 mRNAincreases expression 12673034
D015084 2,4-Dichlorophenoxyacetic Acid 2,4-Dichlorophenoxyacetic Acid results in increased expression of CYP3A7 proteinincreases expression 8812189
D003687 Dehydroepiandrosterone CYP3A7 protein affects the metabolism of Dehydroepiandrosteroneaffects metabolic processing 16041241
D003687 Dehydroepiandrosterone CYP3A7 protein results in increased hydroxylation of Dehydroepiandrosteroneincreases hydroxylation 15985487
15937338
15845858
D019314 Dehydroepiandrosterone Sulfate CYP3A7 promoter polymorphism affects the abundance of Dehydroepiandrosterone Sulfateaffects abundance 15985487
D019314 Dehydroepiandrosterone Sulfate CYP3A7 protein results in increased hydroxylation of Dehydroepiandrosterone Sulfateincreases hydroxylation 15985487
D002117 Calcitriol Calcitriol results in increased expression of CYP3A7 mRNAincreases expression 16002434
D004121 Dimethyl Sulfoxide Dimethyl Sulfoxide affects the expression of CYP3A7 mRNAaffects expression 12843640
D004237 Diuron Diuron results in increased expression of CYP3A7 proteinincreases expression 8812189
D004958 Estradiol Estradiol results in decreased expression of CYP3A7 mRNAdecreases expression 20106945
D004970 Estrone CYP3A7 promoter polymorphism affects the abundance of Estroneaffects abundance 15985487
D004970 Estrone CYP3A7 protein results in increased hydroxylation of Estroneincreases hydroxylation 15985487
D005284 Fenthion CYP3A7 protein affects the metabolism of Fenthionaffects metabolic processing 17110060
D007213 Indomethacin Indomethacin results in decreased expression of CYP3A7 mRNAdecreases expression 16771604
D001556 Lindane Lindane results in increased expression of CYP3A7 proteinincreases expression 8812189
D008294 Malathion CYP3A7 protein affects the metabolism of Malathionaffects metabolic processing 17110060
D010278 Parathion CYP3A7 protein affects the metabolism of Parathionaffects metabolic processing 17110060
17079358
D010416 Pentachlorophenol Pentachlorophenol results in increased expression of CYP3A7 proteinincreases expression 8812189
D010672 Phenytoin Phenytoin results in increased expression of CYP3A7 mRNAincreases expression 12673034
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of CYP3A7 mRNAaffects binding|increases activity|increases expression 19710929
D015474 Isotretinoin Isotretinoin results in decreased expression of CYP3A7 mRNAdecreases expression 15982314
D012293 Rifampin Rifampin results in increased expression of CYP3A7 mRNAincreases expression 12673034
D015085 2,4,5-Trichlorophenoxyacetic Acid 2,4,5-Trichlorophenoxyacetic Acid results in increased expression of CYP3A7 proteinincreases expression 8812189
D016559 Tacrolimus CYP3A7 protein results in decreased methylation of Tacrolimusdecreases methylation 15951320
D013739 Testosterone CYP3A7 protein results in increased hydroxylation of Testosteroneincreases hydroxylation 15845858
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of CYP3A7 mRNAincreases expression 20106945
D014212 Tretinoin CYP3A7 protein affects the metabolism of Tretinoinaffects metabolic processing 16041241
D014212 Tretinoin Tretinoin metabolite results in decreased expression of CYP3A7 mRNAdecreases expression 15982314
D014212 Tretinoin Tretinoin results in decreased expression of CYP3A7 mRNAdecreases expression 15982314
C057693 troglitazone troglitazone results in decreased expression of CYP3A7decreases expression 15618651
D014217 Troleandomycin Troleandomycin results in decreased activity of CYP3A7 proteindecreases activity 17207564
C034028 vanadyl sulfate vanadyl sulfate results in increased expression of CYP3A7 mRNAincreases expression 16330358
D014810 Vitamin E Vitamin E results in decreased expression of CYP3A7 mRNAdecreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Carbamazepine 17.258986270
MESH:D000014 Abnormalities, Drug-Induced Isotretinoin 17.2518769834
MESH:D000014 Abnormalities, Drug-Induced Phenytoin 17.253425630 6195326 8986270 9118846 9677735 10563481
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 17.2511752688 14514962 15322242
MESH:D000015 Abnormalities, Multiple Isotretinoin 4.6318769834
MESH:D017486 Acneiform Eruptions Isotretinoin 5.8816232082
MESH:D000152 Acne Vulgaris Isotretinoin 5.0818769834 16185265
MESH:D055371 Acute Lung Injury pirinixic acid 2.7618653653
MESH:D000230 Adenocarcinoma Estradiol 4.2011473722
MESH:D000230 Adenocarcinoma Indomethacin 4.2016537180
MESH:D000236 Adenoma Indomethacin 3.2211497255
MESH:D018248 Adenoma, Liver Cell pirinixic acid 8.5916434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 8.5916835633
MESH:D000310 Adrenal Gland Neoplasms Pentachlorophenol 5.7010696769
MESH:D000309 Adrenal Insufficiency Dehydroepiandrosterone 5.3817302879
MESH:D000382 Agricultural Workers' Diseases 2,4-Dichlorophenoxyacetic Acid 22.6016132792
MESH:D000382 Agricultural Workers' Diseases Chlorpyrifos 22.6017119214 11874814 16611668
MESH:D000382 Agricultural Workers' Diseases Lindane 22.6012661182
MESH:D000382 Agricultural Workers' Diseases Malathion 22.6017119214 11874814
MESH:D000382 Agricultural Workers' Diseases Parathion 22.6011874814 17119214
MESH:D000505 Alopecia Tretinoin 3.3015955085
MESH:D016301 Alveolar Bone Loss Indomethacin 4.9717225004
MESH:D000544 Alzheimer Disease Indomethacin 2.6117627676 15579461
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.6111748828
MESH:D000987 Antisocial Personality Disorder Testosterone 5.457506515
MESH:D001014 Aortic Aneurysm Indomethacin 4.4710231640
MESH:D017544 Aortic Aneurysm, Abdominal Indomethacin 4.4910388637
MESH:D018771 Arthralgia Indomethacin 4.772160914
MESH:D001169 Arthritis, Experimental Tretinoin 2.8316412693
MESH:D001172 Arthritis, Rheumatoid Indomethacin 4.4111248219
MESH:D001172 Arthritis, Rheumatoid Tretinoin 4.4116292516
MESH:D001249 Asthma Tretinoin 2.2216456186
MESH:D050197 Atherosclerosis Phenytoin 3.6915136057
MESH:D001321 Autistic Disorder Dehydroepiandrosterone Sulfate 4.2415820420
MESH:D001471 Barrett Esophagus Tretinoin 4.0316935849
MESH:D001477 Bartter Syndrome Indomethacin 4.6010684365
MESH:D001714 Bipolar Disorder Carbamazepine 3.9320046352 17594078
MESH:D001778 Blood Coagulation Disorders pirinixic acid 13.2319483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 13.2312125929
MESH:D001778 Blood Coagulation Disorders Tretinoin 13.2316206674 16197459
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.3915340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.5115746008
MESH:D001929 Brain Edema Indomethacin 4.6211481608
MESH:D002545 Brain Ischemia Indomethacin 4.0312524144
MESH:D001943 Breast Neoplasms alitretinoin 6.5116344269
MESH:D001943 Breast Neoplasms Calcitriol 6.5111237771
MESH:D001943 Breast Neoplasms Estradiol 6.5117289903 16675129 19861407 17018787 17261762 14630087 18497071 12948864
MESH:D001943 Breast Neoplasms Indomethacin 6.5117401462
MESH:D001943 Breast Neoplasms Lindane 6.5114688026
MESH:D001943 Breast Neoplasms Malathion 6.5112762645
MESH:D001943 Breast Neoplasms Parathion 6.5112762645
MESH:D001943 Breast Neoplasms Testosterone 6.5117261762
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 6.5120435547
MESH:D001943 Breast Neoplasms Tretinoin 6.5116166294 16443354 16873071
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.2016813970
MESH:D002056 Burns Indomethacin 4.3210459503
MESH:D002100 Cachexia Indomethacin 4.6115625704 15141370 16537180 11239499
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.0716111702
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 3.5516050911
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.4916835633
MESH:D018236 Carcinoma, Embryonal Tretinoin 4.7616168501
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 6.0012619106 21507988 12907637
MESH:D006528 Carcinoma, Hepatocellular Estradiol 6.0016924424
MESH:D006528 Carcinoma, Hepatocellular Indomethacin 6.0016391822
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 6.001917145
MESH:D018827 Carcinoma, Lewis Lung Indomethacin 4.3311053908
MESH:D018276 Carcinoma, Medullary Indomethacin 4.9618791128 14736730 11352223
MESH:D002292 Carcinoma, Renal Cell Indomethacin 3.1817341418
MESH:D002294 Carcinoma, Squamous Cell Calcitriol 9.8211237771
MESH:D002294 Carcinoma, Squamous Cell Indomethacin 9.8215482327 12636206
MESH:D002294 Carcinoma, Squamous Cell Isotretinoin 9.8211237771
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 9.8216096774 16051514
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.1518670907 16120746 18850075
MESH:D002318 Cardiovascular Diseases Tacrolimus 4.3417703430
MESH:D002386 Cataract Tretinoin 2.8617460283
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 5.6712371664
MESH:D002471 Cell Transformation, Neoplastic Estradiol 5.6718566989
MESH:D002493 Central Nervous System Diseases Phenytoin 4.914080065
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.2016129372
MESH:D002659 Child Development Disorders, Pervasive Testosterone 3.5320678186
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 2.8316835633
MESH:D002764 Cholecystitis Indomethacin 4.7711181007
MESH:D002779 Cholestasis Cyclosporine 6.7919486331
MESH:D002779 Cholestasis pirinixic acid 6.7919176532
OMIM:601042 CHOREOATHETOSIS/SPASTICITY, EPISODIC Phenytoin 5.4711748493
MESH:D002822 Choriocarcinoma Tretinoin 4.7616461808
MESH:D002971 Cleft Lip Phenytoin 3.942227380
MESH:D002972 Cleft Palate Phenytoin 8.9010789828 6862529 6856622 3877104 2227380 1687470
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 8.9015340226 16354765 15668235 12621046 8697196
MESH:D002972 Cleft Palate Tretinoin 8.909407595
MESH:D003092 Colitis Tretinoin 3.3217035595
MESH:D003103 Coloboma Phenytoin 4.809212184
MESH:D003110 Colonic Neoplasms Indomethacin 2.5215637740 15625704 15963497 15786552 11260862 15936596
MESH:D015179 Colorectal Neoplasms Indomethacin 2.3517054584 12606626 11197048 18059344
MESH:D000013 Congenital Abnormalities Phenytoin 8.2910627286
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 8.2917141729 14669216
MESH:D018352 Coronavirus Infections Indomethacin 5.3217302372
MESH:D019465 Craniofacial Abnormalities Carbamazepine 8.809014606
MESH:D019465 Craniofacial Abnormalities Isotretinoin 8.809879862 18769834
MESH:D019465 Craniofacial Abnormalities Phenytoin 8.809212184 8986270 19952982
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 8.8020055451 10048152 15322242
MESH:D019465 Craniofacial Abnormalities Tretinoin 8.8010589399 16925845 17551590 9224671 14991402 9211117 9664655 9125849 8800419 9142499
MESH:D019465 Craniofacial Abnormalities Vitamin E 8.8019769572
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.2418249437
MESH:D003921 Diabetes Mellitus, Experimental vanadyl sulfate 4.0616684804
MESH:D003922 Diabetes Mellitus, Type 1 Dehydroepiandrosterone 3.5716616286
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.3617107852
MESH:D003924 Diabetes Mellitus, Type 2 troglitazone 4.3616023994
MESH:D003925 Diabetic Angiopathies troglitazone 5.2512601628
MESH:D003928 Diabetic Nephropathies Estradiol 3.0819279558
MESH:D003967 Diarrhea Indomethacin 3.437237001 7907874
OMIM:607208 DRAVET SYNDROME Carbamazepine 11.1211748493
OMIM:607208 DRAVET SYNDROME Phenytoin 11.1211748493
MESH:D003875 Drug Eruptions Phenytoin 5.1115024534
MESH:D004342 Drug Hypersensitivity Carbamazepine 4.1620216337 16538176 16538175 15057820
MESH:D056486 Drug-Induced Liver Injury Carbamazepine 8.0617465707
MESH:D056486 Drug-Induced Liver Injury Chlorodiphenyl (54% Chlorine) 8.0617851650
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 8.0620420201
MESH:D056486 Drug-Induced Liver Injury troglitazone 8.0614986274
MESH:D004362 Drug Toxicity Carbamazepine 7.4320216337
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 7.4311462148
MESH:D004374 Ductus Arteriosus, Patent Indomethacin 4.7518446180 17190690 16133044 18043480 16326151 12774134
MESH:D004381 Duodenal Ulcer Indomethacin 8.5817351913 17202747 17151854 17045617 11535926 10671773 17329845 11595415 11595431 11991626 16699067
MESH:D004381 Duodenal Ulcer Tacrolimus 8.5817202747
MESH:C538011 Eales disease Vitamin E 4.309068938
MESH:D004487 Edema Indomethacin 9.447990266 7907874 8273558 16100529 10653021 8985016 19703484
MESH:D004487 Edema pirinixic acid 9.4412083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 9.4412711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 10.6118230668 15322242 16714409
MESH:D004489 Edema, Cardiac Tretinoin 10.6118230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Calcitriol 13.5415138306
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Carbamazepine 13.5417654737
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Phenytoin 13.5417654737
MESH:D018159 Endolymphatic Hydrops Dimethyl Sulfoxide 6.1620641076
MESH:D016889 Endometrial Neoplasms Estradiol 6.5518566989 11473722 19148513
MESH:D016889 Endometrial Neoplasms Tretinoin 6.5516569247
MESH:D004715 Endometriosis Indomethacin 7.9415652904
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 7.9410568697 9294722
MESH:D019446 Endotoxemia Indomethacin 4.1118509659
MESH:D004751 Enteritis Indomethacin 4.3510567023 16328016 17763956
MESH:D020345 Enterocolitis, Necrotizing Indomethacin 4.6017980183
MESH:D004802 Eosinophilia Indomethacin 3.6711298111
MESH:D004816 Epidermal Necrolysis, Toxic Carbamazepine 10.4816538176 16415921 19915237 18855540 20485159
MESH:D004816 Epidermal Necrolysis, Toxic Phenytoin 10.4820235791
MESH:D004820 Epidermolysis Bullosa Phenytoin 5.831399206 6251365
MESH:D004831 Epilepsies, Myoclonic Carbamazepine 4.8317275665
MESH:D004828 Epilepsies, Partial Carbamazepine 9.4117116037 16628512 15008574
MESH:D004828 Epilepsies, Partial Phenytoin 9.4111558140 17116037
MESH:D004827 Epilepsy Carbamazepine 6.7418234410 19439326 17178248 821787 20417680 7988514 9014606 19700373 19620853 17465707
MESH:D004827 Epilepsy Phenytoin 6.7420417680 11434505 821787
MESH:D017029 Epilepsy, Complex Partial Carbamazepine 10.797750514
MESH:D017029 Epilepsy, Complex Partial Phenytoin 10.797750514
MESH:D004830 Epilepsy, Tonic-Clonic Carbamazepine 9.9415276670 3659116
MESH:D004830 Epilepsy, Tonic-Clonic Phenytoin 9.943659116
MESH:D004916 Erythromelalgia Carbamazepine 5.3319549232
MESH:D004938 Esophageal Neoplasms Indomethacin 2.7011005569
MESH:D005076 Exanthema Carbamazepine 5.0720485159
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 7.8611564622
MESH:D005124 Eye Abnormalities Tretinoin 7.8616938888 9664655
MESH:D005234 Fatty Liver Cyclosporine 6.4019224547
MESH:D005234 Fatty Liver pirinixic acid 6.4019236843 20131406
MESH:D005313 Fetal Death Phenytoin 9.4610627286
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 9.4611858732
MESH:D005334 Fever Indomethacin 3.7817627676 10431976 11852909
MESH:D005354 Fibrosarcoma Indomethacin 4.5010962813
MESH:D005355 Fibrosis Cyclosporine 18.0012168785 12639820
MESH:D005355 Fibrosis Indomethacin 18.0017994277
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 18.0020067830
MESH:D005355 Fibrosis Tretinoin 18.0017994277
MESH:D005391 Firesetting Behavior Testosterone 5.457506515
MESH:D005499 Folliculitis Indomethacin 4.7711298111
MESH:D005756 Gastritis Indomethacin 4.3515046732
MESH:D005885 Gingival Hyperplasia Cyclosporine 11.598708960
MESH:D005885 Gingival Hyperplasia Phenytoin 11.599029455
MESH:D019214 Gingival Overgrowth Phenytoin 5.8316390469 14659971
MESH:D005909 Glioblastoma Indomethacin 10.5612870263
MESH:D005909 Glioblastoma Testosterone 10.5617162496
MESH:D005909 Glioblastoma Tretinoin 10.5617312396
MESH:D005910 Glioma Indomethacin 3.0618371953 16487511
MESH:D005923 Glomerulosclerosis, Focal Segmental Indomethacin 3.9711849393
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.1910696789
MESH:D006073 Gout Indomethacin 4.9611248219
MESH:D006086 Graft vs Host Disease Tacrolimus 5.4916376943
MESH:D006130 Growth Disorders Tacrolimus 4.6611041285
MESH:D006258 Head and Neck Neoplasms Indomethacin 7.0315482327
MESH:D006258 Head and Neck Neoplasms Tretinoin 7.0316096774
MESH:D034381 Hearing Loss Dimethyl Sulfoxide 4.8420641076
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 4.7616084493
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 9.8910048152 11294989
MESH:D006330 Heart Defects, Congenital Tretinoin 9.899664655 14991402
MESH:D006330 Heart Defects, Congenital Vitamin E 9.8916080930
MESH:D006333 Heart Failure pirinixic acid 2.2920558911
MESH:D006394 Hemangiosarcoma Pentachlorophenol 4.7015200160
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.0315720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 2.9811000095
MESH:D006501 Hepatic Encephalopathy Indomethacin 4.2215633222
MESH:D019698 Hepatitis C, Chronic Indomethacin 4.3115135802
MESH:D006529 Hepatomegaly pirinixic acid 6.9918467677 19176532 16221962 19772884
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 6.9915340226 12621046 16120746
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.5616490937 16863852
MESH:D006558 Herpes Genitalis Estradiol 4.6315709030
MESH:D006628 Hirsutism Testosterone 5.2517019078
MESH:D019584 Hot Flashes Estradiol 8.7117088409
MESH:D019584 Hot Flashes Vitamin E 8.7114716179
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.6416959395 16354765 18606429 15340226 8697196
MESH:D006930 Hyperalgesia Indomethacin 6.9912727271
MESH:D006930 Hyperalgesia Tretinoin 6.9916870215
MESH:D034321 Hyperamylasemia Indomethacin 5.3217883296
MESH:D017588 Hyperandrogenism Dehydroepiandrosterone Sulfate 11.2917392600
MESH:D017588 Hyperandrogenism Testosterone 11.2917019078
MESH:D006940 Hyperemia Indomethacin 4.6112524144
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.1816778211
MESH:D006943 Hyperglycemia pirinixic acid 2.8420558911
MESH:D020138 Hyperhomocysteinemia Carbamazepine 8.8110459572
MESH:D020138 Hyperhomocysteinemia Phenytoin 8.8110459572
MESH:D006949 Hyperlipidemias Indomethacin 3.8017546600
MESH:D006965 Hyperplasia Carbamazepine 4.8318773962
MESH:D006973 Hypertension Cyclosporine 4.4110903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 4.4118850075 18670907
MESH:D007006 Hypogonadism Testosterone 4.3112002444
MESH:C537153 Hypomagnesemia primary Tacrolimus 5.7611041285
MESH:D007018 Hypopituitarism Testosterone 5.8017426086
MESH:D007022 Hypotension Tacrolimus 4.7611041285
MESH:D007077 Ileal Diseases Indomethacin 4.6218306037 10574470
MESH:D007079 Ileitis Indomethacin 4.9610647630 10651667 16133968
MESH:D007174 Impulse Control Disorders Testosterone 5.457506515
MESH:D007235 Infant, Premature, Diseases Indomethacin 4.9716133044
MESH:D007248 Infertility, Male 2,4-Dichlorophenoxyacetic Acid 7.0912948887
MESH:D007248 Infertility, Male Parathion 7.0916029889
MESH:D007249 Inflammation Indomethacin 4.427812673 12568917 3291741
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 4.4212200463 12878042
MESH:D007251 Influenza, Human Vitamin E 3.8116624496
MESH:D007333 Insulin Resistance Estradiol 6.3316393666 16627594
MESH:D007333 Insulin Resistance pirinixic acid 6.3316306350
MESH:D007410 Intestinal Diseases Indomethacin 8.6111855677 15831440 17994277 11686837 18236018 11713966 17329856 10210152 15610444
MESH:D007410 Intestinal Diseases Tretinoin 8.6117994277
MESH:D019586 Intracranial Hypertension Indomethacin 4.9715241188
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 8.7616580747
MESH:D007569 Jaw Abnormalities Tretinoin 8.7615992940 17551590
MESH:D007579 Jejunal Diseases Indomethacin 4.6210574470 16133968 18306037
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.0415604871
MESH:D017492 Keratosis, Seborrheic alitretinoin 5.2416144296
MESH:D007674 Kidney Diseases Cyclosporine 16.628314463 10903974 18776723
MESH:D007674 Kidney Diseases Estradiol 16.6215618244
MESH:D007674 Kidney Diseases Indomethacin 16.6217190690
MESH:D007674 Kidney Diseases Tacrolimus 16.6211041285
MESH:D007674 Kidney Diseases Vitamin E 16.6212488133
MESH:D007680 Kidney Neoplasms Cyclosporine 10.7712371664
MESH:D007680 Kidney Neoplasms Estradiol 10.7715610895
MESH:D007680 Kidney Neoplasms Estrone 10.7715610895
MESH:D016773 Leishmaniasis, Cutaneous Indomethacin 3.5912228301 10320625 11703811
MESH:D007938 Leukemia Tretinoin 2.5717143497
MESH:D004915 Leukemia, Erythroblastic, Acute troglitazone 5.7416085563
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive Indomethacin 3.6316572323 10785260 15631656
MESH:D007951 Leukemia, Myeloid Tretinoin 3.3519285840 16482212 16932348
MESH:D015470 Leukemia, Myeloid, Acute Indomethacin 3.7918360721
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 3.7916294345 19850784 17596541
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 2.8916140955 16788101 17506722 19642359 12679006 17361223 17217047 19075265 19225113 16766008 17368321 17712046 19029980 17107899 16823087 17339181 17301526 15748426 17649720 9834237 17294898 16331271 16935935 19035177 16891316
MESH:D007964 Leukocytosis Indomethacin 4.9716537180
MESH:D007969 Leukomalacia, Periventricular Indomethacin 5.3217980183
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.039224671
MESH:D008101 Liver Abscess, Amebic Indomethacin 5.3211479899
MESH:D008106 Liver Cirrhosis, Experimental Dimethyl Sulfoxide 10.0211682029
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 10.0214716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental Indomethacin 10.0218194892
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 10.0215474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 10.0212878042
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 10.0216248980 18397230
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 10.0216169303
MESH:D008107 Liver Diseases Chlorpyrifos 6.2815991261
MESH:D008107 Liver Diseases Lindane 6.281715830
MESH:D008107 Liver Diseases Phenytoin 6.2814986274
MESH:D008113 Liver Neoplasms Aflatoxin B1 12.5615890375 2125692 18177683 9163691
MESH:D008113 Liver Neoplasms Dehydroepiandrosterone 12.5618709148
MESH:D008113 Liver Neoplasms Pentachlorophenol 12.5610696769
MESH:D008113 Liver Neoplasms pirinixic acid 12.5615890375 20007298 16377806
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 12.5616984957
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 8.538603461
MESH:D008114 Liver Neoplasms, Experimental Dehydroepiandrosterone 8.538603461
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 8.5312151625
MESH:D008171 Lung Diseases Vitamin E 2.9116863852
MESH:D008175 Lung Neoplasms Aflatoxin B1 7.8214755239
MESH:D008175 Lung Neoplasms alitretinoin 7.8216413115
MESH:D008175 Lung Neoplasms Indomethacin 7.8211497255 16537180 11053908
MESH:D008175 Lung Neoplasms Isotretinoin 7.8215899809
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 7.8219555203 11884234
MESH:D008175 Lung Neoplasms Vitamin E 7.8211062179
MESH:D008178 Lupus Erythematosus, Cutaneous Rifampin 5.7311422169
MESH:D008180 Lupus Erythematosus, Systemic Carbamazepine 5.7416628512
MESH:D008180 Lupus Erythematosus, Systemic Rifampin 5.7411422169
MESH:D008223 Lymphoma Pentachlorophenol 4.3312669308
MESH:D008228 Lymphoma, Non-Hodgkin 2,4-Dichlorophenoxyacetic Acid 4.8316132792
MESH:D008325 Mammary Neoplasms, Experimental Dehydroepiandrosterone 5.5916457693
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 5.5916891317 17203775 11408345 11807958
MESH:D020149 Manganese Poisoning Estradiol 4.0819453300
MESH:D008527 Medulloblastoma Tretinoin 2.6217453147
MESH:D008545 Melanoma Isotretinoin 3.4717237267
MESH:D008545 Melanoma Tretinoin 3.4716752155
MESH:D008591 Meningomyelocele Tretinoin 4.0416940565
MESH:D008607 Mental Retardation Carbamazepine 6.059014606
MESH:D008607 Mental Retardation Phenytoin 6.059212184
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.3916801185
MESH:D008881 Migraine Disorders Indomethacin 3.4011903285
MESH:D009062 Mouth Neoplasms Indomethacin 3.6912636206
MESH:D009135 Muscular Diseases pirinixic acid 3.1216239165
MESH:D009164 Mycobacterium Infections Rifampin 5.1518474467
MESH:D009190 Myelodysplastic Syndromes Tretinoin 2.8517596541
MESH:D009203 Myocardial Infarction pirinixic acid 1.9719151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.7112213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 7.2516810080
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 7.2516411023
MESH:D020191 Myoclonic Epilepsies, Progressive Phenytoin 5.1317484760
MESH:D009224 Myotonia Congenita Carbamazepine 11.1720399394
MESH:D009224 Myotonia Congenita Phenytoin 11.171896199
MESH:D009362 Neoplasm Metastasis Indomethacin 3.0016537180 11239499 11053908
MESH:D009369 Neoplasms alitretinoin 10.2516946489
MESH:D009369 Neoplasms Lindane 10.2516818664 12807735
MESH:D009369 Neoplasms pirinixic acid 10.2517405874
MESH:D009369 Neoplasms Tretinoin 10.2516594593 16946489
MESH:D009374 Neoplasms, Experimental Indomethacin 3.7515625704 10663608
MESH:D018301 Neoplasms, Mesothelial Pentachlorophenol 6.2510696769
MESH:D009389 Neovascularization, Pathologic Estradiol 3.3417289903
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.0417954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 2.9518481113 19348381
MESH:D009421 Nervous System Malformations Carbamazepine 20.4116990009
MESH:D009421 Nervous System Malformations Estradiol 20.4116427766 11399458
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 20.4114600291
MESH:D009421 Nervous System Malformations Tretinoin 20.419125849
MESH:D009436 Neural Tube Defects Phenytoin 6.819118846
MESH:D009436 Neural Tube Defects Tretinoin 6.819142499
MESH:D009447 Neuroblastoma Isotretinoin 3.8417368321
MESH:D019636 Neurodegenerative Diseases Indomethacin 8.1112349958
MESH:D019636 Neurodegenerative Diseases Tacrolimus 8.1115081597
MESH:D020258 Neurotoxicity Syndromes Chlorpyrifos 7.9215081274
MESH:D020258 Neurotoxicity Syndromes Malathion 7.9215081274
MESH:D009765 Obesity pirinixic acid 1.7120558911
MESH:D007752 Obstetric Labor, Premature Indomethacin 4.776374098
MESH:D010003 Osteoarthritis Indomethacin 3.437009135
MESH:D010018 Osteomalacia Carbamazepine 11.1717016548
MESH:D010018 Osteomalacia Phenytoin 11.1717016548
MESH:D015663 Osteoporosis, Postmenopausal Dehydroepiandrosterone 4.6716397352
MESH:D010051 Ovarian Neoplasms Estradiol 4.3519401270
MESH:D010051 Ovarian Neoplasms Tretinoin 4.3516936753
MESH:D010146 Pain Carbamazepine 13.6415215642
MESH:D010146 Pain Indomethacin 13.643291741 17440234 13679232 17627676
MESH:D010146 Pain Phenytoin 13.6415215642
MESH:D010146 Pain Tretinoin 13.6416870215
MESH:D010149 Pain, Postoperative Indomethacin 4.2818702446 12538197
MESH:D010190 Pancreatic Neoplasms Tretinoin 2.3215976015
MESH:D010195 Pancreatitis Indomethacin 3.5617883296 15028970
MESH:D010257 Paraneoplastic Syndromes Indomethacin 5.3216537180
MESH:D010267 Parapsoriasis Carbamazepine 5.3116538176
MESH:D020734 Parkinsonian Disorders Indomethacin 3.7812349958
OMIM:167400 PAROXYSMAL EXTREME PAIN DISORDER Carbamazepine 5.5317679678 17145499
MESH:D051302 Paroxysmal Hemicrania Indomethacin 5.3211903285
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 3.8512520081
MESH:D010437 Peptic Ulcer Indomethacin 4.7511148446
MESH:D010518 Periodontitis Indomethacin 4.5117225004
MESH:D017689 Polydactyly Phenytoin 4.719212184
MESH:D017499 Porokeratosis alitretinoin 5.6016144296
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.1818163543
MESH:D011230 Precancerous Conditions Cyclosporine 2.8912371664
MESH:D011248 Pregnancy Complications 2,4-Dichlorophenoxyacetic Acid 10.312087686
MESH:D011248 Pregnancy Complications Carbamazepine 10.319014606
MESH:D047928 Premature Birth Indomethacin 4.7417000239
MESH:D011297 Prenatal Exposure Delayed Effects Carbamazepine 14.239014606
MESH:D011297 Prenatal Exposure Delayed Effects Isotretinoin 14.2318769834
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 14.2311118676 11222880 11896295 11399792
MESH:D011470 Prostatic Hyperplasia Calcitriol 4.3815572423
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 9.6920887781
MESH:D019048 Prostatic Intraepithelial Neoplasia Testosterone 9.6920887781
MESH:D011471 Prostatic Neoplasms Calcitriol 2.2216289102 16644109 18247401 12479363 15754350
MESH:D011471 Prostatic Neoplasms Estradiol 2.2216740699
MESH:D011471 Prostatic Neoplasms Lindane 2.2212661182 14688026
MESH:D011471 Prostatic Neoplasms Vitamin E 2.2215084515
MESH:D011507 Proteinuria Indomethacin 8.1311849393
MESH:D011507 Proteinuria Tretinoin 8.1316636307
MESH:D019310 Pseudolymphoma Carbamazepine 11.629591791 12752131
MESH:D019310 Pseudolymphoma Phenytoin 11.6212752131 1419762 8603615
MESH:D011565 Psoriasis Cyclosporine 2.0816882103
MESH:D011596 Psychomotor Disorders Isotretinoin 5.5218769834
MESH:D011625 Pterygium Tretinoin 4.4016723453
MESH:D011658 Pulmonary Fibrosis troglitazone 3.7318162602
MESH:D015427 Reperfusion Injury pirinixic acid 2.1919058328
MESH:D012135 Respiratory Sounds Chlorpyrifos 14.3017119214 16611668 11874814
MESH:D012135 Respiratory Sounds Malathion 14.3011874814 17119214
MESH:D012135 Respiratory Sounds Parathion 14.3011874814 17119214
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.4618990726
MESH:D012140 Respiratory Tract Diseases Chlorpyrifos 15.7616611668 17119214
MESH:D012140 Respiratory Tract Diseases Malathion 15.7617119214
MESH:D012140 Respiratory Tract Diseases Parathion 15.7617119214
MESH:D012208 Rhabdomyosarcoma Tretinoin 3.7416283617 16116481
MESH:D012640 Seizures Carbamazepine 8.719844417 16876388 16938433 15946322 9046859 19414003 16180713
MESH:D012640 Seizures Lindane 8.717539098 15475178 12842176
MESH:D012640 Seizures Phenytoin 8.713137016 16876388 19919933 10029267 11044598 15946322 9844417 3691417
MESH:D012729 Sex Chromosome Aberrations Chlorpyrifos 5.696418539
MESH:D012735 Sexual Dysfunction, Physiological Testosterone 5.8016631401
MESH:D012871 Skin Diseases Vitamin E 2.3318709164
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 4.9216192470
MESH:D012878 Skin Neoplasms Tretinoin 4.9216467112
MESH:D012893 Sleep Disorders Carbamazepine 4.7319414003
MESH:D013160 Splenic Neoplasms Pentachlorophenol 5.9110696769
MESH:D013262 Stevens-Johnson Syndrome Carbamazepine 10.2916538176 20485159 15057820 18855540 16415921 19915237 19694795
MESH:D013262 Stevens-Johnson Syndrome Phenytoin 10.2920235791
MESH:D013272 Stomach Diseases Indomethacin 4.0315038085 17160473 17207306 10486359 15472012 18209964 16184426 10192188 18545984 10215738 16113693 16280098 17638125
MESH:D013274 Stomach Neoplasms Indomethacin 3.3815609394
MESH:D013274 Stomach Neoplasms Tretinoin 3.3817261132
MESH:D013274 Stomach Neoplasms troglitazone 3.3815930296
MESH:D013276 Stomach Ulcer Indomethacin 3.2517918041 11523592 16397915 18299717 10878458 16169175 15138204 12467913 12077510 11145282 10423059 17654042 16755016 17657623 17895592 11595415 16631530 18726076 17977527 12787963 17627676 14567935 18431645 12498302 17135157 16150113 18543354 10750652 15104355 12500499 11595431 16252198 18181030 11729361 1323529 15255614 18209962 18087811 16934674 18237397 11906479 18193104
MESH:D020521 Stroke Vitamin E 3.2116517955
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.5012697716
MESH:D013964 Thyroid Neoplasms Indomethacin 6.4014736730 11352223 18791128
MESH:D013964 Thyroid Neoplasms Tretinoin 6.4016026305 17045167
MESH:D013978 Tibial Fractures Estradiol 4.2819048282
MESH:D014062 Tongue Neoplasms Tretinoin 3.4516051514
MESH:D014376 Tuberculosis Rifampin 7.6015236969 18397238
MESH:D014376 Tuberculosis Tretinoin 7.6016040207
MESH:D014456 Ulcer Indomethacin 4.5017380554 10574470
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 3.3416129372
MESH:D014604 Uveal Neoplasms Tretinoin 4.2116752155
MESH:D014605 Uveitis Cyclosporine 3.581336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.1912125929
MESH:D014820 Vitiligo Tretinoin 3.6816761959
MESH:D014839 Vomiting Indomethacin 4.3511897121
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 3.8515886252
MESH:D009396 Wilms Tumor Tretinoin 3.6416287080
MESH:D014985 Xerophthalmia Cyclosporine 4.0417120751
Pathway ID Pathway Name
REACT:13433 Biological oxidations
KEGG:00982 Drug metabolism - cytochrome P450
KEGG:00983 Drug metabolism - other enzymes
KEGG:00591 Linoleic acid metabolism
KEGG:01100 Metabolic pathways
KEGG:00980 Metabolism of xenobiotics by cytochrome P450
KEGG:00830 Retinol metabolism
KEGG:00140 Steroid hormone biosynthesis
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA122
    • Releated gene ID Related gene Name
    PA122CYP3A7
    PA378NR1I2
    Releated disease ID Related disease Name
    PA443622Carcinoma, Non-Small-Cell Lung
    PA444818Lung Neoplasms
    PA444447Carcinoma, Hepatocellular
    PA445742Stomach Neoplasms
    Releated drug ID Related drug Name
    PA448084alfentanil
    PA449383docetaxel
    PA450947phenytoin
    PA448785carbamazepine
    PA452609aflatoxin b1
    PA450262loperamide
    PA451627testosterone
    PA451365sirolimus
    PA450496midazolam
    PA451899vitamin d and analogues
    PA452604xenobiotics
    PA449512estrone
    PA449247dexamethasone
    PA450180lansoprazole
    PA450774pantoprazole
    PA451216rabeprazole
    PA451868verapamil
    PA449011cisapride
    PA451578tacrolimus
    PA449686fluticasone propionate
    PA165290926fluticasone/salmeterol
    PA451300salmeterol
    PA452609aflatoxin b1
    PA449957ibuprofen
    Drug Bank Top
    No data
    Drugbank ID Action Drug Name Description
    DB00091 inducer Cyclosporine Antirheumatic Agents;Immunomodulatory Agents;Enzyme Inhibitors;Dermatologic Agents;Immunosuppressive Agents;Antifungal Agents
    DB00176 inhibitor Fluvoxamine Anti-anxiety Agents;Selective Serotonin Reuptake Inhibitors (SSRIs);Antidepressive Agents;Serotonin Uptake Inhibitors;Antidepressive Agents, Second-Generation
    DB00196 inhibitor Fluconazole Antifungals;Antifungal Agents
    DB00197 inducer Troglitazone Antineoplastic Agents;Hypoglycemic Agents;Vasodilator Agents;Platelet Aggregation Inhibitors;Fibrinolytic Agents
    DB00199 inhibitor T-Stat Pad-Lot Anti-Bacterial Agents;Macrolides
    DB00201 substrate Wigraine Tab Central Nervous System Stimulants;Anorexigenic Agents;Phosphodiesterase Inhibitors
    DB00203 substrate Sildenafil Vasodilator Agents;Phosphodiesterase Inhibitors
    DB00220 inhibitor Nelfinavir Anti-HIV Agents;HIV Protease Inhibitors
    DB00224 inhibitor Indinavir Anti-HIV Agents;HIV Protease Inhibitors
    DB00227 substrate Lovastatin Antineoplastic Agents;Anticholesteremic Agents;HMG-CoA Reductase Inhibitors;Hydroxymethylglutaryl-CoA Reductase Inhibitors
    DB00246 substrate Ziprasidone Antipsychotics;Dopamine Antagonists;Serotonin Antagonists;Antipsychotic Agents
    DB00250 substrate Dapsone Anti-Infective Agents;Anti-Infectives;Anti-inflammatory Agents;Antimalarials;Folic Acid Antagonists;Leprostatic Agents;Antimycobacterials
    DB00252 inducer Dilantin W Phenobarbital 30mg Cap Anticonvulsants
    DB00257 inducer Lotrisone Antifungal Agents;Anti-Infective Agents, Local;Growth Inhibitors
    DB00281 substrate Xylonor Spray Antiarrhythmic Agents;Anesthetics;Anesthetics, Local;Anti-Arrhythmia Agents
    DB00318 substrate Co-codamol Narcotics;Analgesics;Opiate Agonists;Antitussives;Analgesics, Opioid;Antitussive Agents
    DB00333 substrate Methadone Narcotics;Analgesics;Opiate Agonists;Antitussives;Analgesics, Opioid;Antitussive Agents
    DB00342 substrate Terfenadine Antiarrhythmic Agents;Anti-Allergic Agents;Antihistamines;Histamine H1 Antagonists, Non-Sedating
    DB00343 inhibitor Diltiazem Antihypertensive Agents;Vasodilator Agents;Calcium Channel Blockers;Cardiovascular Agents
    DB00381 substrate Lotrel Antihypertensive Agents;Vasodilator Agents;Calcium Channel Blockers;Antianginals
    DB00396 inhibitor Synovex S Contraceptives;Progestins
    DB00398 substrate Sorafenib Antineoplastic Agents;Protein Kinase Inhibitors;Anticancer Agents
    DB00401 substrate Nisoldipine Antihypertensive Agents;Vasodilator Agents;Calcium Channel Blockers
    DB00404 substrate Alprazolam Anti-anxiety Agents;Hypnotics and Sedatives;Benzodiazepines;GABA Modulators
    DB00425 substrate Zolpidem GABA Agonists;Hypnotics and Sedatives
    DB00439 substrate Cerivastatin Anticholesteremic Agents;Antilipemic Agents;Hydroxymethylglutaryl-CoA Reductase Inhibitors
    DB00446 inhibitor Zoomycetine Spray Anti-Bacterial Agents;Protein Synthesis Inhibitors
    DB00458 substrate Imipramine Adrenergic Uptake Inhibitors;Antidepressive Agents, Tricyclic;Norepinephrine-Reuptake Inhibitors
    DB00468 substrate Triogene for Antimalarials;Analgesics, Non-Narcotic;Muscle Relaxants, Central
    DB00490 substrate Buspirone Anti-anxiety Agents;Serotonin Agonists;Anxiolytics sedatives and hypnotics
    DB00497 substrate Tylox Narcotics;Opiate Agonists;Antitussives;Analgesics, Opioid
    DB00501 inhibitor Cimetidine Anti-Ulcer Agents;Analgesics;Enzyme Inhibitors;Adjuvants;Histamine Antagonists;Histamine H2 Antagonists
    DB00502 substrate Haloperidol Antiemetics;Antidyskinetics;Antipsychotics;Dopamine Antagonists;Antipsychotic Agents;Butyrophenones;Anti-Dyskinesia Agents
    DB00503 inhibitor Kaletra Anti-HIV Agents;HIV Protease Inhibitors
    DB00514 substrate Tussin Cough Medicine Dm Antitussive Expectorant Decongestant Analgesics, Opioid;Antitussive Agents;Excitatory Amino Acid Antagonists
    DB00528 substrate Lercanidipine Antihypertensive Agents;Calcium Channel Blockers
    DB00531 substrate Procytox for Injection 2000mg Pws Iv Antineoplastic Agents;Antirheumatic Agents;Immunosuppressive Agents;Antineoplastic Agents, Alkylating;Myeloablative Agonists;Mutagens
    DB00537 inhibitor Ciprodex Anti-Infective Agents;Anti-Infectives;Quinolones;Nucleic Acid Synthesis Inhibitors
    DB00541 substrate Vincristine Antineoplastic Agents;Antineoplastic Agents, Phytogenic;Tubulin Modulators
    DB00564 substrate Carbamazepine Anticonvulsants;Analgesics;Antimanic Agents;Analgesics, Non-Narcotic
    DB00571 substrate Propranolol Anti-anxiety Agents;Antihypertensive Agents;Adrenergic Agents;Adrenergic beta-Antagonists;Vasodilator Agents;Antiarrhythmic Agents;Anti-Arrhythmia Agents
    DB00582 inhibitor Voriconazole Antifungals;Antifungal Agents
    DB00588 substrate Fluticasone Propionate Anti-inflammatory Agents;Adrenergic Agents;Dermatologic Agents;Bronchodilator Agents;Anti-Allergic Agents
    DB00593 substrate Ethosuximide Anticonvulsants;Succinimides
    DB00604 substrate Cisapride Anti-Ulcer Agents;Gastrointestinal Agents;Serotonin Agonists;Prokinetic Agents
    DB00619 inhibitor Imatinib Antineoplastic Agents;Protein Kinase Inhibitors
    DB00624 substrate Uni-Bol Androgens
    DB00637 substrate Astemizole Anti-Allergic Agents;Antihistamines;Histamine H1 Antagonists, Non-Sedating
    DB00641 substrate Vytorin Anticholesteremic Agents;Antilipemic Agents;Hydroxymethylglutaryl-CoA Reductase Inhibitors
    DB00647 inducer Propoxyphene Narcotics;Analgesics;Antitussives;Analgesics, Opioid
    DB00656 substrate Trazodone Anti-anxiety Agents;Antidepressants, Second-Generation;Serotonin Uptake Inhibitors;Antidepressive Agents, Second-Generation
    DB00661 inhibitor Tarka Vasodilator Agents;Antiarrhythmic Agents;Calcium Channel Blockers;Anti-Arrhythmia Agents
    DB00673 inhibitor Aprepitant Antiemetics
    DB00675 substrate Tamoxifen Antineoplastic Agents, Hormonal;Selective Estrogen Receptor Modulators;Estrogen Antagonists;Bone Density Conservation Agents
    DB00683 inhibitor Midazolam Anti-anxiety Agents;Hypnotics and Sedatives;Adjuvants, Anesthesia;GABA Modulators;Anesthetics, Intravenous
    DB00700 substrate Eplerenone Antihypertensive Agents;Aldosterone Antagonists
    DB00705 inhibitor Delavirdine Anti-HIV Agents;Nonnucleoside Reverse Transcriptase Inhibitors;Reverse Transcriptase Inhibitors
    DB00717 substrate Synphasic (28 day) Contraceptives, Oral, Synthetic;Progestins
    DB00731 substrate Nateglinide Hypoglycemic Agents;Meglitinides
    DB00734 substrate Risperidone Antipsychotics;Dopamine Antagonists;Serotonin Antagonists;Antipsychotic Agents
    DB00741 substrate Vosol Hc Anti-inflammatory Agents
    DB00755 substrate Tretinoin Antineoplastic Agents;Keratolytic Agents;Cell Stimulants and Proliferants
    DB00762 substrate Irinotecan Antineoplastic Agents;Radiation-Sensitizing Agents;Parasympathomimetics;Enzyme Inhibitors;Prodrugs;Antineoplastic Agents, Phytogenic
    DB00780 inhibitor Phenelzine Antidepressants;Antidepressive Agents;Monoamine Oxidase Inhibitors
    DB00783 substrate Triquilar 21 Anticholesteremic Agents;Estrogens;Anti-menopausal Agents
    DB00802 substrate Alfentanil Narcotics;Analgesics;Anesthetics;Anesthetics, Intravenous;Opiate Agonists;Analgesics, Opioid
    DB00813 substrate Innovar Injection Narcotics;Analgesics;Adjuvants, Anesthesia;Anesthetics;Anesthetics, Intravenous;Opiate Agonists;Analgesics, Opioid;Adjuvants
    DB00829 substrate Diazepam Anti-anxiety Agents;Hypnotics and Sedatives;Antiemetics;Anticonvulsants;Adjuvants, Anesthesia;GABA Modulators;Anesthetics, Intravenous;Muscle Relaxants, Central
    DB00834 inhibitor Mifepristone Contraceptives, Oral, Synthetic;Menstruation-Inducing Agents;Luteolytic Agents;Contraceptives, Postcoital, Synthetic;Hormone Antagonists;Abortifacient Agents, Steroidal
    DB00842 substrate Oxazepam Anti-anxiety Agents;Hypnotics and Sedatives;GABA Modulators
    DB00864 substrate Tacrolimus Immunosuppressive Agents
    DB00877 substrate Sirolimus Anti-Bacterial Agents;Antifungals;Immunosuppressive Agents;Antifungal Agents;Antibiotics, Antineoplastic;Macrolides
    DB00897 substrate Triazolam Anti-anxiety Agents;Benzodiazepines;Adjuvants, Anesthesia;GABA Modulators
    DB00904 substrate Ondansetron Anti-anxiety Agents;Antiemetics;Antipsychotics;Serotonin Antagonists;Antipruritics;Antipsychotic Agents
    DB00907 substrate Cocaine Vasoconstrictor Agents;Dopamine Uptake Inhibitors;Anesthetics;Local Anesthetics;Anesthetics, Local
    DB00908 substrate Quinidine Enzyme Inhibitors;Antiarrhythmic Agents;Antimalarials;Muscarinic Antagonists;Adrenergic alpha-Antagonists;Anti-Arrhythmia Agents
    DB00921 substrate Buprenorphine Narcotics;Analgesics, Opioid;Narcotic Antagonists
    DB00938 substrate Advair 500 Diskus Bronchodilator Agents;Adrenergic beta-Agonists;Sympathomimetic
    DB00943 substrate Zalcitabine Anti-HIV Agents;Antimetabolites;Nucleoside and Nucleotide Reverse Transcriptase Inhibitors;Reverse Transcriptase Inhibitors
    DB00962 substrate Zaleplon Hypnotics and Sedatives;Anticonvulsants;Anxiolytics sedatives and hypnotics
    DB00976 inhibitor Telithromycin Anti-Bacterial Agents;Ketolides
    DB01023 substrate Lexxel Antihypertensive Agents;Vasodilator Agents;Calcium Channel Blockers;Dihydropyridines
    DB01026 inhibitor Ketoconazole Antifungals;Antifungal Agents
    DB01045 inducer Rifater Enzyme Inhibitors;Antituberculosis Agents;Nucleic Acid Synthesis Inhibitors;Leprostatic Agents;Antibiotics;Antibiotics, Antitubercular
    DB01054 substrate Nitrendipine Antihypertensive Agents;Vasodilator Agents;Calcium Channel Blockers
    DB01058 substrate Drontal Tab Anthelmintics
    DB01059 inhibitor Norfloxacin Anti-Infectives;Anti-Bacterial Agents;Enzyme Inhibitors;Quinolones;Nucleic Acid Synthesis Inhibitors
    DB01076 substrate Caduet Anticholesteremic Agents;HMG-CoA Reductase Inhibitors;Hydroxymethylglutaryl-CoA Reductase Inhibitors
    DB01100 substrate Pimozide Dopamine Antagonists;Antipsychotic Agents;Anti-Dyskinesia Agents
    DB01114 substrate Triaminicol Dm Syrup Antipruritics;Anti-Allergic Agents;Histamine H1 Antagonists;Antihistamines
    DB01115 substrate Nifedipine Vasodilator Agents;Calcium Channel Blockers;Tocolytic Agents;Dihydropyridines
    DB01118 inhibitor Amiodarone Vasodilator Agents;Enzyme Inhibitors;Anti-Arrhythmia Agents
    DB01149 inhibitor Nefazodone Antidepressants;Analgesics;Antidepressive Agents, Second-Generation;Serotonin Agents
    DB01166 substrate Cilostazol Vasodilator Agents;Platelet Aggregation Inhibitors;Fibrinolytic Agents;Phosphodiesterase Inhibitors;Bronchodilator Agents;Neuroprotective Agents
    DB01167 inhibitor Itraconazole Antifungals;Antiprotozoals;Antifungal Agents;Antiprotozoal Agents
    DB01181 substrate Ifosfamide Antineoplastic Agents;Immunosuppressive Agents;Antineoplastic Agents, Alkylating
    DB01184 substrate Domperidone Antiemetics;Dopamine Antagonists
    DB01201 inducer Rifapentine Leprostatic Agents;Antimycobacterials;Antibiotics, Antitubercular
    DB01211 inhibitor Clarithromycin Anti-Bacterial Agents;Other Macrolides;Protein Synthesis Inhibitors;Macrolides
    DB01216 substrate Finasteride Enzyme Inhibitors;Skin and Mucous Membrane Agents;Anti-baldness Agents;Antihyperplasia Agents
    DB01224 substrate Quetiapine Antipsychotics;Antipsychotic Agents
    DB01227 substrate Levomethadyl Acetate Narcotics;Analgesics, Opioid
    DB01229 substrate Paclitaxel Antineoplastic Agents;Antineoplastic Agents, Phytogenic;Tubulin Modulators
    DB01232 inhibitor Saquinavir Anti-HIV Agents;HIV Protease Inhibitors
    DB01234 inducer Tresaderm Dermatologic Solution Anti-inflammatory Agents;Adrenergic Agents;Antiemetics;Antineoplastic Agents, Hormonal;Glucocorticoids
    DB01238 substrate Aripiprazole Antipsychotics;Antipsychotic Agents
    DB01248 substrate Docetaxel Antineoplastic Agents;Radiation-Sensitizing Agents;Antimalarials;Antineoplastic Agents, Phytogenic
    DB01268 substrate Sunitinib Antineoplastic Agents;Angiogenesis Inhibitors
    DB01388 inhibitor Mibefradil Antihypertensive Agents;Vasodilator Agents;Calcium Channel Blockers
    DB01424 substrate Aminophenazone Analgesics;Pyrazolones
    DB01466 substrate Ethylmorphine Narcotics;Analgesics, Opioid;Antitussive Agents
    DB06287 substrate Temsirolimus Antineoplastic Agents;Protein Kinase Inhibitors
    DB06730 inhibitor Gestodene
    DB06731 inhibitor Seproxetine
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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