AutismKB 2.0

Annotation Detail for CYP2A13


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Basic Information Top
Gene Symbol:CYP2A13 ( CPAD,CYP2A )
Gene Full Name: cytochrome P450, family 2, subfamily A, polypeptide 13
Band: 19q13.2
Quick LinksEntrez ID:1553; OMIM: 608055; Uniprot ID:CP2AD_HUMAN; ENSEMBL ID: ENSG00000197838; HGNC ID: 2608
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa00830Retinol metabolism
hsa00982Drug metabolism - cytochrome P450
hsa00983Drug metabolism - other enzymes
hsa01100Metabolic pathways
hsa00232Caffeine metabolism
Pathway IDPathway Name
Biological oxidations
No data
No data
Pathway IDPathway Name
500197Xenobiotics
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1848Embryoma
2066Lung cancer
Desease Name
CANCER
lung cancer
uterine fibroids
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C006757 4-biphenylamine CYP2A13 protein results in increased hydroxylation of and results in increased activity of 4-biphenylamineincreases activity|increases hydroxylation 16988941
C016583 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone CYP2A13 gene polymorphism results in decreased hydroxylation of 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanonedecreases hydroxylation 17922361
C016583 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone CYP2A13 protein affects the metabolism of 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanoneaffects metabolic processing 12920169
15608128
17717079
C016583 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone CYP2A13 protein results in increased hydroxylation of 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanoneincreases hydroxylation 17922361
C016583 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone CYP2A13 protein results in increased metabolism of 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanoneincreases metabolic processing 17717079
C016583 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone CYP2A13 protein results in increased metabolism of and results in increased activity of 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanoneincreases activity|increases metabolic processing 16917071
17671098
14633739
C016583 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone CYP2A13 protein SNP results in decreased metabolism of 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanonedecreases metabolic processing 14633739
C016583 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone Methoxsalen inhibits the reaction [CYP2A13 protein results in increased metabolism of and results in increased activity of 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone]decreases reaction|increases activity|increases metabolic processing 17671098
D016604 Aflatoxin B1 CYP2A13 protein results in increased metabolism of and results in increased activity of Aflatoxin B1increases activity|increases metabolic processing 16917071
C030123 coumarin CYP2A13 gene polymorphism results in decreased hydroxylation of coumarindecreases hydroxylation 17922361
C030123 coumarin CYP2A13 protein results in increased hydroxylation of coumarinincreases hydroxylation 17922361
D008730 Methoxsalen Methoxsalen inhibits the reaction [CYP2A13 protein results in increased metabolism of and results in increased activity of 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone]decreases reaction|increases activity|increases metabolic processing 17671098
C062567 N-methyl-N-2-(methylsulfinyl)ethylpropionic acid amide CYP2A13 protein results in increased activity of N-methyl-N-2-(methylsulfinyl)ethylpropionic acid amideincreases activity 15725615
C036676 N-nitrosoguvacoline CYP2A13 protein results in increased activity of N-nitrosoguvacolineincreases activity 15725615
C008655 N'-nitrosonornicotine CYP2A13 protein results in increased hydroxylation of N'-nitrosonornicotineincreases hydroxylation 17922361
D011794 Quercetin Quercetin results in decreased expression of CYP2A13 mRNAdecreases expression 16455785
C005266 quinomethionate quinomethionate results in increased expression of CYP2A13 mRNAincreases expression 18214805
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000236 Adenoma 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone 3.9616176798
MESH:D000743 Anemia, Hemolytic Quercetin 4.4117084956
MESH:D001260 Ataxia Telangiectasia Quercetin 5.2115336622
MESH:D001327 Autoimmune Diseases Quercetin 4.6219761891
MESH:D001943 Breast Neoplasms 4-biphenylamine 2.3517671175
MESH:D001943 Breast Neoplasms 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone 2.3520146248
MESH:D001943 Breast Neoplasms Quercetin 2.3518628248
MESH:D002105 Cadmium Poisoning Quercetin 5.8116962696
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 3.2912619106 21507988 12907637
MESH:D006528 Carcinoma, Hepatocellular Quercetin 3.2912508355 19519916
MESH:D021441 Carcinoma, Pancreatic Ductal Quercetin 5.1717234771
MESH:D006332 Cardiomegaly Quercetin 3.4019794523
MESH:D002471 Cell Transformation, Neoplastic 4-biphenylamine 4.8615746073
MESH:D043171 Chromosomal Instability 4-biphenylamine 7.2817671175
MESH:D003110 Colonic Neoplasms Quercetin 2.4411134977 16640504 17191121 17148506 19440933 19056647 15741050
MESH:D015179 Colorectal Neoplasms 4-biphenylamine 3.3117671175
MESH:D015179 Colorectal Neoplasms Quercetin 3.3118852136 18095365
MESH:D003921 Diabetes Mellitus, Experimental Quercetin 3.8719496084
MESH:D003924 Diabetes Mellitus, Type 2 coumarin 3.2319647726
MESH:D004485 Eczema Methoxsalen 6.2216259964
MESH:D005355 Fibrosis Quercetin 4.1119474275
MESH:D005909 Glioblastoma Quercetin 3.5019804834
MESH:D005910 Glioma Quercetin 3.1117643826
MESH:D006943 Hyperglycemia Quercetin 4.1918262572 11834736
MESH:D006973 Hypertension Quercetin 2.9118356687
MESH:D007251 Influenza, Human Quercetin 4.7716624496
MESH:D007627 Keloid Quercetin 5.1717086741
MESH:D007674 Kidney Diseases Quercetin 3.1916962696
MESH:D007938 Leukemia Quercetin 3.2317468513
MESH:D008106 Liver Cirrhosis, Experimental Quercetin 2.1912741479
MESH:D008113 Liver Neoplasms 4-biphenylamine 11.3815761837
MESH:D008113 Liver Neoplasms 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone 11.3815890375
MESH:D008113 Liver Neoplasms Aflatoxin B1 11.3818177683 2125692 15890375 9163691
MESH:D008113 Liver Neoplasms Quercetin 11.3818980244
MESH:D008114 Liver Neoplasms, Experimental 4-biphenylamine 10.8011376689
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 10.808603461
MESH:D008114 Liver Neoplasms, Experimental Quercetin 10.8019519916
MESH:D008175 Lung Neoplasms 4-biphenylamine 6.8817671175
MESH:D008175 Lung Neoplasms 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone 6.8815893417 16401635 18508827 18813816 14755239 15172992 19931552 16061637 17139156 9255578 12438228
MESH:D008175 Lung Neoplasms Aflatoxin B1 6.8814755239
MESH:D008175 Lung Neoplasms Methoxsalen 6.8815893417
MESH:D008175 Lung Neoplasms Quercetin 6.8816280456
MESH:D008708 Methemoglobinemia 4-biphenylamine 5.5912030840
MESH:D009182 Mycosis Fungoides Methoxsalen 6.9016259964
MESH:D009203 Myocardial Infarction Quercetin 3.0519595682
MESH:D015428 Myocardial Reperfusion Injury Quercetin 3.9219207477
MESH:D009369 Neoplasms Quercetin 2.8715185748
MESH:D020078 Neurogenic Inflammation Quercetin 4.5517929310
MESH:D015663 Osteoporosis, Postmenopausal Quercetin 4.4019495926
MESH:D010051 Ovarian Neoplasms Quercetin 2.7819005980
MESH:D010190 Pancreatic Neoplasms 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone 5.9512384795
MESH:D010190 Pancreatic Neoplasms Quercetin 5.9516965848
MESH:D011230 Precancerous Conditions Quercetin 4.1319056647
MESH:D011471 Prostatic Neoplasms Quercetin 3.5714715546 17292933
MESH:D011565 Psoriasis Methoxsalen 4.6716259964
MESH:D012554 Schistosomiasis japonica Quercetin 5.8116862918
MESH:D013274 Stomach Neoplasms N'-nitrosonornicotine 3.9618456281
MESH:D001749 Urinary Bladder Neoplasms 4-biphenylamine 6.1312376482 11144890 6654951 17671175
MESH:D001749 Urinary Bladder Neoplasms Quercetin 6.1316720314
MESH:D014689 Venous Insufficiency coumarin 6.0412708602
MESH:D014820 Vitiligo Methoxsalen 6.2816259964
Pathway ID Pathway Name
REACT:13433 Biological oxidations
KEGG:00232 Caffeine metabolism
KEGG:00982 Drug metabolism - cytochrome P450
KEGG:00983 Drug metabolism - other enzymes
KEGG:01100 Metabolic pathways
KEGG:00830 Retinol metabolism
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA27101
    • Releated gene ID Related gene Name
    PA27101CYP2A13
    Releated disease ID Related disease Name
    PA444818Lung Neoplasms
    PA446661Carcinoma, Small Cell
    PA443265Adenocarcinoma
    PA444447Carcinoma, Hepatocellular
    Releated drug ID Related drug Name
    PA452609aflatoxin b1
    PA450262loperamide
    PA451627testosterone
    PA452604xenobiotics
    PA450626nicotine
    PA134521193coumarin
    PA452609aflatoxin b1
    Drug Bank Top
    No data
    Drugbank ID Action Drug Name Description
    DB00184 substrate Nicotine Anti-craving Agents;Central Nervous System Agents;Autonomic drugs;Nicotinic Agonists;Ganglionic Stimulants
    DB00553 inhibitor Methoxsalen Antineoplastic Agents;Cross-Linking Reagents;Photosensitizing Agents;Pigmenting Agents
    DB00624 substrate Uni-Bol Androgens
    DB01242 - Clomipramine Antidepressive Agents, Tricyclic;Serotonin Uptake Inhibitors
    DB03783 substrate Phenacetin Analgesics;Analgesics, Non-Narcotic
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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