AutismKB 2.0

Annotation Detail for CYP2C8


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Basic Information Top
Gene Symbol:CYP2C8 ( CPC8,MP-12/MP-20 )
Gene Full Name: cytochrome P450, family 2, subfamily C, polypeptide 8
Band: 10q23.33
Quick LinksEntrez ID:1558; OMIM: 601129; Uniprot ID:CP2C8_HUMAN; ENSEMBL ID: ENSG00000138115; HGNC ID: 2622
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa00830Retinol metabolism
hsa00590Arachidonic acid metabolism
hsa00980Metabolism of xenobiotics by cytochrome P450
hsa00982Drug metabolism - cytochrome P450
hsa01100Metabolic pathways
hsa00591Linoleic acid metabolism
Pathway IDPathway Name
Biological oxidations
No data
No data
Pathway IDPathway Name
500197Xenobiotics
Related Diseases/Disorders Top
No data
No data
Desease Name
ibuprofen clearance
reduced plasma concentrations of repaglinide
CARDIOVASCULAR
myocardial infarct
rosiglitazone pharmacokinetics
Multiple Myeloma
CANCER
PHARMACOGENOMIC
hypertension
repaglinide pharmacology
paclitaxel pharmacokinetics
METABOLIC
Jaw Diseases
osteonecrosis of the jaw
hepatotoxicity, diclofenac-induced
osteonecrosis
Desease Name
Osteonecrosis of the jaw
Desease Name
Rhabdomyolysis, cerivastatin-induced
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C035342 1,4-naphthoquinone CYP2C8 protein results in increased abundance of 1,4-naphthoquinoneincreases abundance 16243959
C029350 1-naphthol CYP2C8 protein results in increased abundance of 1-naphtholincreases abundance 16243959
C024336 1-phenylazo-2-naphthol CYP2C8 protein results in increased oxidation of 1-phenylazo-2-naphtholincreases oxidation 17159775
C109602 3-(2-(4-(3-chloro-2-methylphenyl)1-piperazinyl)ethyl)5,6-dimethoxy-1-(4-imidazolylmethyl)-1H-indazol dihydrochloride 3.5 hydrate 3-(2-(4-(3-chloro-2-methylphenyl)1-piperazinyl)ethyl)5,6-dimethoxy-1-(4-imidazolylmethyl)-1H-indazol dihydrochloride 3.5 hydrate results in decreased activity of CYP2C8 proteindecreases activity 16049129
C109602 3-(2-(4-(3-chloro-2-methylphenyl)1-piperazinyl)ethyl)5,6-dimethoxy-1-(4-imidazolylmethyl)-1H-indazol dihydrochloride 3.5 hydrate CYP2C8 protein affects the metabolism of 3-(2-(4-(3-chloro-2-methylphenyl)1-piperazinyl)ethyl)5,6-dimethoxy-1-(4-imidazolylmethyl)-1H-indazol dihydrochloride 3.5 hydrateaffects metabolic processing 16049129
C502236 5-(4-(3-(4-cyclohexyl-2-propylphenoxy)propoxy)phenyl)-1,3-oxazolidine-2,4-dione CYP2C8 protein results in increased hydroxylation of 5-(4-(3-(4-cyclohexyl-2-propylphenoxy)propoxy)phenyl)-1,3-oxazolidine-2,4-dioneincreases hydroxylation 15708677
C475093 6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime [6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime binds to NR1I3 protein] which binds to CYP2C8 promoteraffects binding 15933212
C475093 6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime 6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime results in increased expression of CYP2C8 mRNAincreases expression 15933212
C086219 6-hydroxytaxol CYP2C8 protein results in increased chemical synthesis of 6-hydroxytaxolincreases chemical synthesis 12401345
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of CYP2C8 proteinaffects expression 20106945
D000638 Amiodarone Amiodarone results in decreased activity of CYP2C8 proteindecreases activity 15304522
D000638 Amiodarone CYP2C8 protein results in increased metabolism of Amiodaroneincreases metabolic processing 15716363
D000638 Amiodarone torsemide inhibits the reaction [Amiodarone results in decreased activity of CYP2C8 protein]decreases activity|decreases reaction 15304522
D000655 Amodiaquine CYP2C8 protein affects the metabolism of Amodiaquineaffects metabolic processing 15626586
12920490
D000655 Amodiaquine CYP2C8 protein results in increased metabolism of Amodiaquineincreases metabolic processing 15155557
15601807
17565714
D000655 Amodiaquine [Gemfibrozil co-treated with Amodiaquine] results in decreased activity of CYP2C8 proteinaffects cotreatment|decreases activity 15771232
D001095 Arachidonic Acids CYP2C8 protein affects the metabolism of Arachidonic Acidsaffects metabolic processing 15933212
C010831 bufuralol CYP2C8 protein results in increased hydroxylation of bufuralolincreases hydroxylation 9429232
D002047 Buprenorphine CYP2C8 protein affects the metabolism of Buprenorphineaffects metabolic processing 16010532
C077793 candesartan cilexetil candesartan cilexetil results in decreased activity of CYP2C8 proteindecreases activity 15601807
D002220 Carbamazepine Carbamazepine results in increased expression of CYP2C8 mRNAincreases expression 17112801
D002220 Carbamazepine CYP2C8 protein affects the metabolism of Carbamazepineaffects metabolic processing 15915352
15286053
D002220 Carbamazepine CYP2C8 protein results in increased metabolism of Carbamazepineincreases metabolic processing 12464242
D002220 Carbamazepine Probenecid promotes the reaction [CYP2C8 protein affects the metabolism of Carbamazepine]affects metabolic processing|increases reaction 15915352
C012227 carbamazepine epoxide CYP2C8 protein affects the chemical synthesis of carbamazepine epoxideaffects chemical synthesis 15915352
C012227 carbamazepine epoxide Probenecid promotes the reaction [CYP2C8 protein affects the chemical synthesis of carbamazepine epoxide]affects chemical synthesis|increases reaction 15915352
C086276 cerivastatin CYP2C8 protein results in increased metabolism of cerivastatinincreases metabolic processing 12464242
15716363
D020111 Chlorodiphenyl (54% Chlorine) Chlorodiphenyl (54% Chlorine) results in increased expression of CYP2C8 mRNAincreases expression 17851650
D002738 Chloroquine CYP2C8 protein affects the metabolism of Chloroquineaffects metabolic processing 12920490
C045316 cinitapride CYP2C8 protein results in increased metabolism of cinitaprideincreases metabolic processing 17437965
C029010 cinnamic acid cinnamic acid analog results in decreased activity of CYP2C8 proteindecreases activity 15072549
D002995 Clofibric Acid Clofibric Acid results in increased activity of CYP2C8 proteinincreases activity 15771232
D002995 Clofibric Acid Clofibric Acid results in increased expression of CYP2C8 mRNAincreases expression 15771232
D002995 Clofibric Acid Clofibric Acid results in increased expression of CYP2C8 proteinincreases expression 15771232
D003022 Clotrimazole Clotrimazole results in decreased activity of CYP2C8 proteindecreases activity 15601807
D003042 Cocaine Cocaine results in decreased expression of CYP2C8 mRNAdecreases expression 16188404
D003042 Cocaine Cocaine results in decreased expression of CYP2C8 proteindecreases expression 16188404
D016572 Cyclosporine Cyclosporine results in decreased expression of CYP2C8 mRNAdecreases expression 20106945
C047386 desethylamodiaquine CYP2C8 protein results in increased chemical synthesis of desethylamodiaquineincreases chemical synthesis 15155557
D003907 Dexamethasone [Dexamethasone binds to NR3C1 protein] which binds to CYP2C8 promoteraffects binding 15933212
D003907 Dexamethasone Dexamethasone results in increased expression of CYP2C8 mRNAincreases expression 15933212
D004294 Domperidone CYP2C8 protein results in increased hydroxylation of Domperidoneincreases hydroxylation 15327587
D004958 Estradiol Estradiol results in decreased expression of CYP2C8 mRNAdecreases expression 20106945
D004997 Ethinyl Estradiol Ethinyl Estradiol results in decreased activity of CYP2C8 proteindecreases activity 15601807
D015736 Felodipine Felodipine results in decreased activity of CYP2C8 proteindecreases activity 15601807
D011345 Fenofibrate Fenofibrate results in decreased activity of CYP2C8 proteindecreases activity 15601807
C006012 fenofibric acid fenofibric acid results in increased activity of CYP2C8 proteinincreases activity 15771232
C006012 fenofibric acid fenofibric acid results in increased expression of CYP2C8 mRNAincreases expression 15771232
C006012 fenofibric acid fenofibric acid results in increased expression of CYP2C8 proteinincreases expression 15771232
D005473 Fluoxetine Fluoxetine results in decreased activity of CYP2C8 proteindecreases activity 15304522
D005473 Fluoxetine torsemide inhibits the reaction [Fluoxetine results in decreased activity of CYP2C8 protein]decreases activity|decreases reaction 15304522
D015248 Gemfibrozil [Gemfibrozil co-treated with Amodiaquine] results in decreased activity of CYP2C8 proteinaffects cotreatment|decreases activity 15771232
D015248 Gemfibrozil Gemfibrozil inhibits the reaction [CYP2C8 protein affects the metabolism of pioglitazone]affects metabolic processing|decreases reaction 15900286
D015248 Gemfibrozil Gemfibrozil metabolite results in decreased activity of CYP2C8 proteindecreases activity 16042675
D015248 Gemfibrozil Gemfibrozil results in decreased activity of CYP2C8 proteindecreases activity 15771232
D015248 Gemfibrozil Gemfibrozil results in decreased expression of CYP2C8 proteindecreases expression 15771232
D015248 Gemfibrozil Gemfibrozil results in increased expression of CYP2C8 mRNAincreases expression 15771232
D007052 Ibuprofen CYP2C8 gene polymorphism affects the metabolism of Ibuprofenaffects metabolic processing 15606441
D007052 Ibuprofen CYP2C8 gene polymorphism results in decreased metabolism of Ibuprofendecreases metabolic processing 15289789
D007052 Ibuprofen CYP2C8 gene polymorphism results in increased metabolism of Ibuprofenincreases metabolic processing 18694831
C081309 irbesartan irbesartan results in decreased activity of CYP2C8 proteindecreases activity 15601807
D007538 Isoniazid Isoniazid results in decreased activity of CYP2C8 proteindecreases activity 15304522
D007538 Isoniazid torsemide inhibits the reaction [Isoniazid results in decreased activity of CYP2C8 protein]decreases activity|decreases reaction 15304522
D007654 Ketoconazole Ketoconazole results in decreased activity of CYP2C8 proteindecreases activity 15601807
14709627
D017336 Loratadine Loratadine results in decreased activity of CYP2C8 proteindecreases activity 15601807
D008148 Lovastatin Lovastatin results in decreased activity of CYP2C8 proteindecreases activity 15601807
D008525 Medroxyprogesterone Medroxyprogesterone results in decreased activity of CYP2C8 proteindecreases activity 15601807
C053915 mometasone furoate mometasone furoate results in decreased activity of CYP2C8 proteindecreases activity 15601807
C093875 montelukast montelukast results in decreased activity of CYP2C8 proteindecreases activity 15601807
C093875 montelukast montelukast results in decreased activity of CYP2C8 proteindecreases activity 16670899
D018721 Muscarinic Agonists CYP2C8 protein affects the metabolism of Muscarinic Agonistsaffects metabolic processing 16041192
D009173 Mycophenolic Acid CYP2C8 protein results in increased methylation of Mycophenolic Acidincreases methylation 15570183
D009529 Nicardipine CYP2C8 protein affects the metabolism of Nicardipineaffects metabolic processing 15863898
D009529 Nicardipine Nicardipine results in decreased activity of CYP2C8 proteindecreases activity 15863898
D009543 Nifedipine Nifedipine results in decreased activity of CYP2C8 proteindecreases activity 15601807
D009661 Nortriptyline Nortriptyline results in decreased activity of CYP2C8 proteindecreases activity 15304522
D009661 Nortriptyline torsemide inhibits the reaction [Nortriptyline results in decreased activity of CYP2C8 protein]decreases activity|decreases reaction 15304522
C005419 oxybutynin oxybutynin results in decreased activity of CYP2C8 proteindecreases activity 15601807
D017239 Paclitaxel CYP2C8 mRNA results in increased susceptibility to Paclitaxelincreases response to substance 15239142
D017239 Paclitaxel CYP2C8 protein affects the metabolism of Paclitaxelaffects metabolic processing 15901749
15933212
D017239 Paclitaxel CYP2C8 protein results in increased metabolism of Paclitaxelincreases metabolic processing 16124035
15716363
12464242
12401345
D010278 Parathion CYP2C8 protein affects the metabolism of Parathionaffects metabolic processing 12669189
D010622 Phencyclidine CYP2C8 protein affects the metabolism of Phencyclidineaffects metabolic processing 16782764
D010624 Phenelzine Phenelzine results in decreased activity of CYP2C8 proteindecreases activity 15304522
D010624 Phenelzine torsemide inhibits the reaction [Phenelzine results in decreased activity of CYP2C8 protein]decreases activity|decreases reaction 15304522
C060836 pioglitazone CYP2C8 protein affects the metabolism of pioglitazoneaffects metabolic processing 15900286
C060836 pioglitazone Gemfibrozil inhibits the reaction [CYP2C8 protein affects the metabolism of pioglitazone]affects metabolic processing|decreases reaction 15900286
C060836 pioglitazone pioglitazone results in decreased activity of CYP2C8 proteindecreases activity 12642470
D011339 Probenecid Probenecid promotes the reaction [CYP2C8 protein affects the chemical synthesis of carbamazepine epoxide]affects chemical synthesis|increases reaction 15915352
D011339 Probenecid Probenecid promotes the reaction [CYP2C8 protein affects the metabolism of Carbamazepine]affects metabolic processing|increases reaction 15915352
D011794 Quercetin Quercetin results in decreased activity of CYP2C8 proteindecreases activity 15601807
15155557
D011794 Quercetin [Quercetin results in decreased activity of CYP2C8 protein] which results in decreased degradation of vanoxerinedecreases activity|decreases degradation 11502731
D020849 Raloxifene Raloxifene results in decreased activity of CYP2C8 proteindecreases activity 15601807
C072379 repaglinide CYP2C8 protein affects the metabolism of repaglinideaffects metabolic processing 16042675
D012293 Rifampin [Rifampin binds to NR1I2 protein] which binds to CYP2C8 promoteraffects binding 15933212
D012293 Rifampin Rifampin results in increased activity of CYP2C8 proteinincreases activity 15771232
D012293 Rifampin Rifampin results in increased expression of CYP2C8 mRNAincreases expression 17954527
15771232
15933212
12040753
D012293 Rifampin Rifampin results in increased expression of CYP2C8 proteinincreases expression 15771232
D019438 Ritonavir Ritonavir results in decreased activity of CYP2C8 proteindecreases activity 15601807
C089730 rosiglitazone CYP2C8 protein results in increased metabolism of rosiglitazoneincreases metabolic processing 12464242
C089730 rosiglitazone rosiglitazone results in decreased activity of CYP2C8 proteindecreases activity 12642470
C057823 salmeterol salmeterol results in decreased activity of CYP2C8 proteindecreases activity 15601807
D019821 Simvastatin Simvastatin results in decreased activity of CYP2C8 proteindecreases activity 15601807
D013148 Spironolactone Spironolactone results in decreased activity of CYP2C8 proteindecreases activity 15601807
D013411 Sulfadiazine CYP2C8 protein results in increased hydroxylation of Sulfadiazineincreases hydroxylation 15843491
D013442 Sulfinpyrazone Sulfinpyrazone results in decreased activity of CYP2C8 proteindecreases activity 12464242
D013974 Thyroxine Thyroxine results in decreased activity of CYP2C8 proteindecreases activity 15601807
D013629 Tamoxifen Tamoxifen results in decreased activity of CYP2C8 proteindecreases activity 15601807
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of CYP2C8 mRNAdecreases expression 20106945
D013750 Tetrachloroethylene CYP2C8 protein results in increased metabolism of Tetrachloroethyleneincreases metabolic processing 11684365
C109005 thiocoraline CYP2C8 protein affects the metabolism of thiocoralineaffects metabolic processing 15122071
D014044 Tolbutamide CYP2C8 protein results in increased hydroxylation of Tolbutamideincreases hydroxylation 15843491
C026116 torsemide CYP2C8 protein results in increased metabolism of torsemideincreases metabolic processing 15304522
C026116 torsemide torsemide inhibits the reaction [Amiodarone results in decreased activity of CYP2C8 protein]decreases activity|decreases reaction 15304522
C026116 torsemide torsemide inhibits the reaction [Fluoxetine results in decreased activity of CYP2C8 protein]decreases activity|decreases reaction 15304522
C026116 torsemide torsemide inhibits the reaction [Isoniazid results in decreased activity of CYP2C8 protein]decreases activity|decreases reaction 15304522
C026116 torsemide torsemide inhibits the reaction [Nortriptyline results in decreased activity of CYP2C8 protein]decreases activity|decreases reaction 15304522
C026116 torsemide torsemide inhibits the reaction [Phenelzine results in decreased activity of CYP2C8 protein]decreases activity|decreases reaction 15304522
C026116 torsemide torsemide inhibits the reaction [Verapamil results in decreased activity of CYP2C8 protein]decreases activity|decreases reaction 15304522
C507866 trans-1,2-dihydro-1,2-naphthalenediol CYP2C8 protein results in increased abundance of trans-1,2-dihydro-1,2-naphthalenediolincreases abundance 16243959
D014212 Tretinoin CYP2C8 protein affects the metabolism of Tretinoinaffects metabolic processing 15933212
D014212 Tretinoin CYP2C8 protein results in increased metabolism of Tretinoinincreases metabolic processing 12464242
D014295 Trimethoprim CYP2C8 protein results in increased metabolism of Trimethoprimincreases metabolic processing 12464242
D014295 Trimethoprim Trimethoprim results in decreased activity of CYP2C8 proteindecreases activity 15570183
C057693 troglitazone troglitazone results in decreased activity of CYP2C8 proteindecreases activity 12642470
C043425 vanoxerine CYP2C8 protein results in decreased degradation of vanoxerinedecreases degradation 11502731
C043425 vanoxerine [Quercetin results in decreased activity of CYP2C8 protein] which results in decreased degradation of vanoxerinedecreases activity|decreases degradation 11502731
D014700 Verapamil torsemide inhibits the reaction [Verapamil results in decreased activity of CYP2C8 protein]decreases activity|decreases reaction 15304522
D014700 Verapamil Verapamil results in decreased activity of CYP2C8 proteindecreases activity 15304522
C062735 zafirlukast zafirlukast results in decreased activity of CYP2C8 proteindecreases activity 15601807
C062735 zafirlukast zafirlukast results in decreased activity of CYP2C8 proteindecreases activity 16670899
C515050 zopiclone CYP2C8 protein results in increased metabolism of zopicloneincreases metabolic processing 12464242
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 3.7614745880
MESH:D000014 Abnormalities, Drug-Induced Carbamazepine 6.188986270
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 6.1811752688 15322242 14514962
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.1617505938
MESH:D058186 Acute Kidney Injury Ibuprofen 3.766375363
MESH:D000230 Adenocarcinoma Estradiol 5.5611473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 5.5614692618
MESH:D000230 Adenocarcinoma Ibuprofen 5.5610697514
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 2.6116835633
MESH:D000382 Agricultural Workers' Diseases Parathion 4.2511874814 17119214
MESH:D000419 Albuminuria Raloxifene 3.8617308373 17451421
OMIM:607154 ALLERGIC RHINITIS Loratadine 8.9516527031
OMIM:607154 ALLERGIC RHINITIS zafirlukast 8.9516527031
MESH:D000505 Alopecia Tretinoin 2.9815955085
MESH:D000544 Alzheimer Disease Ibuprofen 5.3618351690
MESH:D000544 Alzheimer Disease Raloxifene 5.3615800139
MESH:D000544 Alzheimer Disease rosiglitazone 5.3619621015
MESH:D000707 Anaphylaxis Ibuprofen 4.499532969
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.2711748828
MESH:D000743 Anemia, Hemolytic Quercetin 3.5417084956
MESH:D000799 Angioedema montelukast 10.4710982225
MESH:D000799 Angioedema salmeterol 10.4710982225
MESH:D001008 Anxiety Disorders Fluoxetine 4.3018083778
MESH:D001145 Arrhythmias, Cardiac Amiodarone 3.1320041841 18057881 18218290
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 2.7211256880
MESH:D001169 Arthritis, Experimental Dexamethasone 9.2117659584
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 9.2115885639
MESH:D001169 Arthritis, Experimental Tretinoin 9.2116412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.0316292516
MESH:D001249 Asthma Loratadine 11.649196086
MESH:D001249 Asthma montelukast 11.6419681236 16293801 17895592 20332717 10852428 19667530
MESH:D001249 Asthma salmeterol 11.6410359889 11694805
MESH:D001249 Asthma Tretinoin 11.6416456186
MESH:D001249 Asthma zafirlukast 11.649196086 11061985 12114351 10386485 15572850 15170009 19681236 11991558 9027267 10027429 12113382 9620946 10817796 11596838 14609035 10852428 10934090 1673495 12604023 10439636 11393122 9949315 9825082 11070746 15136378 12742009 9690572 8087328 9377612 8222486 12583521 10359889 19667530 10967152 9701106 8162986 10780761 9620945 10929920 9847434 10064661 12189465 20332717 11570617 12095178 9412547 11885876 11694805 18489783
MESH:D055963 Asthma, Aspirin-Induced montelukast 8.6619667532
MESH:D055963 Asthma, Aspirin-Induced zafirlukast 8.6619667532
MESH:D001250 Asthma, Exercise-Induced montelukast 15.1719667531 10984370
MESH:D001250 Asthma, Exercise-Induced salmeterol 15.1710984370
MESH:D001250 Asthma, Exercise-Induced zafirlukast 15.178389103 1554195 10984370 11953129 19667531
MESH:D001260 Ataxia Telangiectasia Quercetin 4.2115336622
MESH:D001281 Atrial Fibrillation Amiodarone 3.3018651412 19698954
MESH:D001321 Autistic Disorder Fluoxetine 3.1318775368 19232924
MESH:D001321 Autistic Disorder pioglitazone 3.1317207275
MESH:D001327 Autoimmune Diseases Quercetin 3.6619761891
MESH:D001471 Barrett Esophagus Tretinoin 3.6616935849
MESH:D001714 Bipolar Disorder Carbamazepine 3.6820046352 17594078
MESH:D001778 Blood Coagulation Disorders Amiodarone 11.3519483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 11.3512125929
MESH:D001778 Blood Coagulation Disorders Tretinoin 11.3516206674 16197459
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.0115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.2215746008
MESH:D001859 Bone Neoplasms Paclitaxel 3.8515867366
MESH:D001930 Brain Injuries Raloxifene 3.7216580743
MESH:D002545 Brain Ischemia Ibuprofen 4.1215837124
MESH:D001943 Breast Neoplasms Estradiol 4.6017261762 19861407 16675129 14630087 17289903 17018787 12948864 18497071
MESH:D001943 Breast Neoplasms Paclitaxel 4.6016273361 15136595 18223236 16115903 18234424 11325840 16244791 18323546
MESH:D001943 Breast Neoplasms Parathion 4.6012762645
MESH:D001943 Breast Neoplasms Quercetin 4.6018628248
MESH:D001943 Breast Neoplasms Raloxifene 4.6016837676 17242785 15775269 17893378 17440819 16912660 17595753 15758505 17952589 15572757 17261762 17049068
MESH:D001943 Breast Neoplasms Tamoxifen 4.6019155303 16873071 19059307 15565566 19288272 19189210 20390343 19115204 19244106 19189212 17242785 19410462 18997820 20544844 19487384 21138602 21152245 20135344 16273361 19142967 19200415 18855134 16818667 18815881 20005174 17893378 18629630 15668708 19103187 18351453 18821012 19011961 20065188 19084267 19066611 16202921 17440819 19221464 18425577 11161223 18984771 17261762 17049068 20859285 19289846
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 4.6020435547
MESH:D001943 Breast Neoplasms Tetrachloroethylene 4.6015986119
MESH:D001943 Breast Neoplasms Tretinoin 4.6016873071 16166294 16443354
MESH:D001982 Bronchial Diseases zafirlukast 5.9511994701
MESH:D029481 Bronchitis, Chronic salmeterol 5.7617687719
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 3.8216813970
MESH:D002100 Cachexia Ibuprofen 4.7015141370
MESH:D002105 Cadmium Poisoning Quercetin 4.7616962696
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 10.6316111702
MESH:D002181 Candidiasis, Vulvovaginal zafirlukast 10.6315170009
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.1716835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 3.7519066611
MESH:D018236 Carcinoma, Embryonal Tretinoin 4.3716168501
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 8.8812619106 12907637 21507988
MESH:D006528 Carcinoma, Hepatocellular Estradiol 8.8816924424
MESH:D006528 Carcinoma, Hepatocellular Paclitaxel 8.8816313753
MESH:D006528 Carcinoma, Hepatocellular Quercetin 8.8812508355 19519916
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 8.8816924424
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 8.881917145
MESH:D021441 Carcinoma, Pancreatic Ductal Quercetin 4.2017234771
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 2.0316096774 16051514
MESH:D002295 Carcinoma, Transitional Cell Raloxifene 7.2417572228
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 7.2417572228
MESH:D006332 Cardiomegaly Quercetin 8.7119794523
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 8.7118670907 18850075 16120746
MESH:D006332 Cardiomegaly Thyroxine 8.7118093424
MESH:D002311 Cardiomyopathy, Dilated Amiodarone 2.5615710769 19225199
MESH:D002318 Cardiovascular Diseases Raloxifene 6.1415775269
MESH:D002318 Cardiovascular Diseases Spironolactone 6.1411230374
MESH:D002341 Carotid Artery Thrombosis Amiodarone 4.3118974383
MESH:D002386 Cataract Simvastatin 6.2812518039
MESH:D002386 Cataract Tretinoin 6.2817460283
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 4.7012371664
MESH:D002471 Cell Transformation, Neoplastic Estradiol 4.7018566989
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 3.8216129372
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 2.5016835633
MESH:D002779 Cholestasis Cyclosporine 5.7819486331
MESH:D002779 Cholestasis Ethinyl Estradiol 5.7816105132 17333356 17681005 17110522 16919318 15861022 11677210
MESH:D002822 Choriocarcinoma Tretinoin 4.3716461808
MESH:D015267 Churg-Strauss Syndrome zafirlukast 5.619674492
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 4.4416354765 15668235 8697196 12621046 15340226
MESH:D002972 Cleft Palate Tretinoin 4.449407595
MESH:D019970 Cocaine-Related Disorders Cocaine 4.9519606084
MESH:D003072 Cognition Disorders Raloxifene 3.8715800139
MESH:D003092 Colitis Tretinoin 2.9617035595
MESH:D003110 Colonic Neoplasms Dexamethasone 3.3115824018
MESH:D003110 Colonic Neoplasms Quercetin 3.3111134977 17148506 16640504 19440933 15741050 19056647 17191121
MESH:D015179 Colorectal Neoplasms Paclitaxel 2.5718802399
MESH:D015179 Colorectal Neoplasms Quercetin 2.5718852136 18095365
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.4014669216 17141729
MESH:D003233 Conjunctivitis, Allergic zafirlukast 5.1515351322
MESH:D003327 Coronary Disease Felodipine 5.4318504504
MESH:D003371 Cough zafirlukast 4.8612095178
MESH:D019465 Craniofacial Abnormalities Carbamazepine 4.369014606
MESH:D019465 Craniofacial Abnormalities Dexamethasone 4.3617728286
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 4.3610048152 20055451 15322242
MESH:D019465 Craniofacial Abnormalities Tretinoin 4.369664655 17551590 14991402 10589399 9142499 16925845 9211117 9125849 9224671 8800419
MESH:D003550 Cystic Fibrosis pioglitazone 10.9219747007
MESH:D003550 Cystic Fibrosis Simvastatin 10.9219747007
MESH:D003550 Cystic Fibrosis zafirlukast 10.9215463842
MESH:D003665 Decompression Sickness zafirlukast 5.6118309904
MESH:D003711 Demyelinating Diseases Tamoxifen 3.6119031437
MESH:D003866 Depressive Disorder Fluoxetine 4.0315014590
MESH:D003865 Depressive Disorder, Major Raloxifene 3.5017474826
MESH:D017449 Dermatitis, Allergic Contact Dexamethasone 2.7212438553
MESH:D003876 Dermatitis, Atopic zafirlukast 4.0511901593
MESH:D003920 Diabetes Mellitus rosiglitazone 3.6417446233
MESH:D003921 Diabetes Mellitus, Experimental Quercetin 3.0919496084
MESH:D003924 Diabetes Mellitus, Type 2 pioglitazone 8.1316023994 12642470
MESH:D003924 Diabetes Mellitus, Type 2 rosiglitazone 8.1312642470
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 8.1317107852
MESH:D003924 Diabetes Mellitus, Type 2 troglitazone 8.1316023994
MESH:D003925 Diabetic Angiopathies troglitazone 4.8812601628
MESH:D003928 Diabetic Nephropathies Estradiol 11.1919279558
MESH:D003928 Diabetic Nephropathies Raloxifene 11.1915920148 17308373 17451421
MESH:D003928 Diabetic Nephropathies Tamoxifen 11.1919279558
MESH:D003967 Diarrhea Arachidonic Acids 6.747237001
MESH:D003967 Diarrhea Dexamethasone 6.747237001
OMIM:607208 DRAVET SYNDROME Carbamazepine 4.6911748493
MESH:D004342 Drug Hypersensitivity Carbamazepine 3.8916538176 15057820 16538175 20216337
MESH:D056486 Drug-Induced Liver Injury Amiodarone 19.6315265979 18218290
MESH:D056486 Drug-Induced Liver Injury Carbamazepine 19.6317465707
MESH:D056486 Drug-Induced Liver Injury Chlorodiphenyl (54% Chlorine) 19.6317851650
MESH:D056486 Drug-Induced Liver Injury Isoniazid 19.6316770646 14986274 17950035
MESH:D056486 Drug-Induced Liver Injury Ketoconazole 19.6318289764
MESH:D056486 Drug-Induced Liver Injury Ritonavir 19.6314986274
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 19.6320420201
MESH:D056486 Drug-Induced Liver Injury troglitazone 19.6314986274
MESH:D056486 Drug-Induced Liver Injury zafirlukast 19.6311119397 12583521
MESH:D004362 Drug Toxicity Carbamazepine 6.4020216337
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 6.4011462148
MESH:D004374 Ductus Arteriosus, Patent Ibuprofen 4.8416133044 18446180 18450898
MESH:D050171 Dyslipidemias Fenofibrate 7.6816707586
MESH:D050171 Dyslipidemias Gemfibrozil 7.6816707586
MESH:D004415 Dyspepsia cinitapride 6.5119819042 1820589 8218764
MESH:D004485 Eczema Dexamethasone 3.7312438553
MESH:D004487 Edema Dexamethasone 18.2119703484
MESH:D004487 Edema Fluoxetine 18.2112798668
MESH:D004487 Edema Raloxifene 18.2115860553
MESH:D004487 Edema rosiglitazone 18.2112083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 18.2112711302 11000095
MESH:D004487 Edema zafirlukast 18.2115351322
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 9.3416714409 18230668 15322242
MESH:D004489 Edema, Cardiac Tretinoin 9.3418230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Carbamazepine 16.0017654737
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 16.0012538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Raloxifene 16.0015845917
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 16.0019031437
MESH:D016889 Endometrial Neoplasms Estradiol 13.3018566989 11473722 19148513
MESH:D016889 Endometrial Neoplasms Fenofibrate 13.3016569247
MESH:D016889 Endometrial Neoplasms Tamoxifen 13.3016202921 19155303 20544844 17893378
MESH:D016889 Endometrial Neoplasms Tretinoin 13.3016569247
MESH:D004715 Endometriosis Ibuprofen 11.6315652904
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 11.6310568697 9294722
MESH:D004715 Endometriosis zafirlukast 11.6315019815
MESH:D019446 Endotoxemia Ibuprofen 4.2011545620
MESH:D004802 Eosinophilia montelukast 7.5010335014
MESH:D004802 Eosinophilia zafirlukast 7.5015351322 12689652 15696079 12189465 12742009
MESH:D004816 Epidermal Necrolysis, Toxic Carbamazepine 4.5218855540 20485159 16538176 16415921 19915237
MESH:D004831 Epilepsies, Myoclonic Carbamazepine 4.4617275665
MESH:D004828 Epilepsies, Partial Carbamazepine 4.2017116037 16628512 15008574
MESH:D004827 Epilepsy Carbamazepine 3.5417178248 19620853 18234410 821787 7988514 19439326 9014606 19700373 20417680 17465707
MESH:D017029 Epilepsy, Complex Partial Carbamazepine 4.607750514
MESH:D004830 Epilepsy, Tonic-Clonic Carbamazepine 4.3615276670 3659116
MESH:D004916 Erythromelalgia Carbamazepine 4.9519549232
MESH:D004938 Esophageal Neoplasms Paclitaxel 2.6516481741
MESH:D005076 Exanthema Carbamazepine 4.7020485159
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 6.8211564622
MESH:D005124 Eye Abnormalities Tretinoin 6.8216938888 9664655
MESH:D005234 Fatty Liver Amiodarone 21.8014986274
MESH:D005234 Fatty Liver Cyclosporine 21.8019224547
MESH:D005234 Fatty Liver Ethinyl Estradiol 21.8015345470
MESH:D005234 Fatty Liver Raloxifene 21.8017473493
MESH:D005234 Fatty Liver rosiglitazone 21.8019196556
MESH:D005234 Fatty Liver Tamoxifen 21.8014986274 19224547
MESH:D052776 Female Urogenital Diseases Tamoxifen 2.7116709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 2.7111858732
MESH:D005334 Fever Ibuprofen 3.9116997862
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 3.7614745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 3.4119069698
MESH:D005355 Fibrosis Cyclosporine 19.9012168785 12639820
MESH:D005355 Fibrosis Felodipine 19.9018504504
MESH:D005355 Fibrosis Quercetin 19.9019474275
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 19.9020067830
MESH:D005355 Fibrosis Tretinoin 19.9017994277
MESH:D005596 Fractures, Closed montelukast 5.3819544365
MESH:D005764 Gastroesophageal Reflux cinitapride 5.871626164
MESH:D005767 Gastrointestinal Diseases cinitapride 6.161820589
MESH:D005885 Gingival Hyperplasia Cyclosporine 3.458708960
MESH:D005909 Glioblastoma Quercetin 5.4419804834
MESH:D005909 Glioblastoma Tretinoin 5.4417312396
MESH:D005910 Glioma Quercetin 2.6917643826
MESH:D015432 Glomerulonephritis, Membranoproliferative Spironolactone 5.2716928621
MESH:D005923 Glomerulosclerosis, Focal Segmental pioglitazone 4.6116687628
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 3.8110696789
MESH:D006261 Headache zafirlukast 4.819377612 10386485
MESH:D006258 Head and Neck Neoplasms Tretinoin 2.6316096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 4.3716084493
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 4.9710048152 11294989
MESH:D006330 Heart Defects, Congenital Tretinoin 4.9714991402 9664655
MESH:D006331 Heart Diseases Raloxifene 2.9711110106
MESH:D006333 Heart Failure torsemide 4.9618001696
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 3.6515720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 2.6411000095
MESH:D006505 Hepatitis zafirlukast 4.5112189465
MESH:D006529 Hepatomegaly Amiodarone 6.0715265979
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 6.0715340226 16120746 12621046
MESH:D006548 Hernia, Diaphragmatic Dexamethasone 2.747520565
MESH:D006556 Heroin Dependence Buprenorphine 6.3012756210
MESH:D006558 Herpes Genitalis Estradiol 4.2515709030
MESH:D015658 HIV Infections Ritonavir 4.1217378895 15388451 11141242 11363243
MESH:D019584 Hot Flashes Estradiol 7.9517088409
MESH:D019584 Hot Flashes Fluoxetine 7.9514716179
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.2618606429 8697196 16959395 15340226 16354765
MESH:D006930 Hyperalgesia rosiglitazone 5.9912083418
MESH:D006930 Hyperalgesia Tretinoin 5.9916870215
MESH:D006937 Hypercholesterolemia Amiodarone 3.189751232 8137927
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 3.8116778211
MESH:D006943 Hyperglycemia Quercetin 3.3518262572 11834736
MESH:D020138 Hyperhomocysteinemia Carbamazepine 4.0610459572
MESH:D006938 Hyperlipoproteinemia Type II Simvastatin 4.5816238680
MESH:D017495 Hyperpigmentation 1-phenylazo-2-naphthol 6.471402006
MESH:D006965 Hyperplasia Carbamazepine 4.4618773962
MESH:D006973 Hypertension Cyclosporine 22.9310903974
MESH:D006973 Hypertension Dexamethasone 22.9317042910
MESH:D006973 Hypertension irbesartan 22.9318464745 11593098 11910301 12022239 14700505 13678427 15614026 15453913 12359989 15188945
MESH:D006973 Hypertension Nifedipine 22.9320102058
MESH:D006973 Hypertension Quercetin 22.9318356687
MESH:D006973 Hypertension Raloxifene 22.9317577099 15787275
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 22.9318850075 18670907
MESH:D006973 Hypertension Verapamil 22.9317700361
MESH:D006976 Hypertension, Pulmonary zafirlukast 4.2512781059
MESH:D006984 Hypertrophy Ibuprofen 4.2816672835
MESH:D020514 Hypokalemic Periodic Paralysis Spironolactone 5.3919822448
MESH:D007021 Hypospadias Ethinyl Estradiol 9.3116569931 16945680
MESH:D007021 Hypospadias Loratadine 9.3116407038
MESH:D007037 Hypothyroidism Amiodarone 3.7618020914 17991464
MESH:D007235 Infant, Premature, Diseases Ibuprofen 5.0516133044
MESH:D007247 Infertility, Female Ethinyl Estradiol 2.7512013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 5.3517937319
MESH:D007248 Infertility, Male Parathion 5.3516029889
MESH:D007249 Inflammation Dexamethasone 23.9011099482 8960868
MESH:D007249 Inflammation Fluoxetine 23.9012798668
MESH:D007249 Inflammation Ibuprofen 23.903291741
MESH:D007249 Inflammation montelukast 23.9018059327
MESH:D007249 Inflammation pioglitazone 23.9016908763
MESH:D007249 Inflammation rosiglitazone 23.9012083418
MESH:D007249 Inflammation Tamoxifen 23.9019457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 23.9012878042 12200463
MESH:D007249 Inflammation zafirlukast 23.9011438310 18309904
MESH:D007251 Influenza, Human Quercetin 3.7316624496
MESH:D007333 Insulin Resistance Estradiol 5.8016393666 16627594
MESH:D007333 Insulin Resistance rosiglitazone 5.8016306350
MESH:D007410 Intestinal Diseases Tretinoin 3.0217994277
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 7.6116580747
MESH:D007569 Jaw Abnormalities Tretinoin 7.6115992940 17551590
MESH:D007627 Keloid Quercetin 4.2017086741
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 3.6615604871
MESH:D007674 Kidney Diseases Cyclosporine 7.1918776723 10903974 8314463
MESH:D007674 Kidney Diseases Estradiol 7.1915618244
MESH:D007674 Kidney Diseases Quercetin 7.1916962696
MESH:D007680 Kidney Neoplasms Cyclosporine 8.6712371664
MESH:D007680 Kidney Neoplasms Estradiol 8.6715610895
MESH:D007680 Kidney Neoplasms Tamoxifen 8.6718625569
MESH:D007889 Leiomyoma Raloxifene 3.7816973256
MESH:D016773 Leishmaniasis, Cutaneous Ketoconazole 4.0619744259 8889330 1311351 2166429
MESH:D007898 Leishmaniasis, Visceral Ketoconazole 3.9411332679
MESH:D007938 Leukemia Quercetin 4.9617468513
MESH:D007938 Leukemia Tretinoin 4.9617143497
MESH:D004915 Leukemia, Erythroblastic, Acute troglitazone 5.3616085563
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell Ritonavir 4.8016174765
MESH:D007951 Leukemia, Myeloid Tretinoin 3.0016482212 19285840 16932348
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 1.9119850784 17596541 16294345
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 2.6116788101 16331271 17649720 17506722 19225113 16766008 17294898 17368321 16823087 19029980 17107899 17217047 17361223 15748426 16891316 16140955 17712046 16935935 19035177 12679006 9834237 17301526 19642359 19075265 17339181
MESH:D007964 Leukocytosis zafirlukast 5.6118489783
MESH:D017880 Limb Deformities, Congenital Tretinoin 2.729224671
MESH:D008064 Lipidoses Amiodarone 18.4217567588 15342952
MESH:D008064 Lipidoses Fluoxetine 18.4217567588 15342952
MESH:D008064 Lipidoses Ketoconazole 18.4217567588
MESH:D008064 Lipidoses Loratadine 18.4217567588
MESH:D008064 Lipidoses Tamoxifen 18.4217567588 15342952
MESH:D008080 Liposarcoma Paclitaxel 4.1017353645
MESH:D008106 Liver Cirrhosis, Experimental candesartan cilexetil 14.7314620537
MESH:D008106 Liver Cirrhosis, Experimental Dexamethasone 14.7316718785
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 14.7314716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental Fenofibrate 14.7315474484
MESH:D008106 Liver Cirrhosis, Experimental pioglitazone 14.7315052691 16484506
MESH:D008106 Liver Cirrhosis, Experimental Quercetin 14.7312741479
MESH:D008106 Liver Cirrhosis, Experimental rosiglitazone 14.7317347453 15980055
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 14.7318564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 14.7312878042
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 14.7318397230 16248980
MESH:D008107 Liver Diseases Tetrachloroethylene 3.4917267091
MESH:D008113 Liver Neoplasms Aflatoxin B1 13.152125692 15890375 9163691 18177683
MESH:D008113 Liver Neoplasms Clofibric Acid 13.1517602206
MESH:D008113 Liver Neoplasms Fenofibrate 13.1518978307
MESH:D008113 Liver Neoplasms Quercetin 13.1518980244
MESH:D008113 Liver Neoplasms Tamoxifen 13.1516684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 13.1516984957
MESH:D008114 Liver Neoplasms, Experimental 1-phenylazo-2-naphthol 16.542563599
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 16.548603461
MESH:D008114 Liver Neoplasms, Experimental Fenofibrate 16.5418253720 18775883
MESH:D008114 Liver Neoplasms, Experimental Quercetin 16.5419519916
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 16.5412151625
MESH:D008114 Liver Neoplasms, Experimental Tetrachloroethylene 16.547955063
MESH:D008133 Long QT Syndrome Amiodarone 2.9715350150 17391786 11989578
MESH:D008171 Lung Diseases Amiodarone 2.8212587719
MESH:D017563 Lung Diseases, Interstitial Amiodarone 3.7018516814
MESH:D008173 Lung Diseases, Obstructive zafirlukast 5.259847434
MESH:D008175 Lung Neoplasms Aflatoxin B1 5.0514755239
MESH:D008175 Lung Neoplasms Dexamethasone 5.0511195469 15824018
MESH:D008175 Lung Neoplasms Quercetin 5.0516280456
MESH:D008175 Lung Neoplasms Tamoxifen 5.0518625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 5.0511884234 19555203
MESH:D008178 Lupus Erythematosus, Cutaneous Rifampin 5.3611422169
MESH:D008180 Lupus Erythematosus, Systemic Carbamazepine 5.1616628512
MESH:D008180 Lupus Erythematosus, Systemic Rifampin 5.1611422169
MESH:D008228 Lymphoma, Non-Hodgkin Paclitaxel 3.4514749477
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 3.0019428831
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 9.9116891317 11807958 11408345 17203775
MESH:D008325 Mammary Neoplasms, Experimental Ibuprofen 9.9110697514
MESH:D008325 Mammary Neoplasms, Experimental rosiglitazone 9.9116827153
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 9.9111731420 19196722 14580682 16827153 19196723
MESH:D020149 Manganese Poisoning Estradiol 10.0419453300
MESH:D020149 Manganese Poisoning Tamoxifen 10.0419453300
MESH:D008527 Medulloblastoma Tretinoin 2.4117453147
MESH:D008545 Melanoma Paclitaxel 4.0016342250 12040289 12025231
MESH:D008545 Melanoma Tamoxifen 4.0012393984 19393235
MESH:D008545 Melanoma Tretinoin 4.0016752155
MESH:D018328 Melanoma, Amelanotic Tamoxifen 3.4115990972
MESH:D008591 Meningomyelocele Tretinoin 3.6716940565
MESH:D001523 Mental Disorders Fluoxetine 6.8016856516
MESH:D001523 Mental Disorders Nortriptyline 6.8016856516
MESH:D008607 Mental Retardation Carbamazepine 3.409014606
MESH:D024821 Metabolic Syndrome X rosiglitazone 3.7317261469
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.0016801185
MESH:D008708 Methemoglobinemia Chloroquine 5.013537620
MESH:D008881 Migraine Disorders montelukast 6.7510759916
MESH:D008881 Migraine Disorders zafirlukast 6.7510759916
MESH:D018200 Mixed Tumor, Mullerian Raloxifene 4.7715863610
MESH:D009101 Multiple Myeloma Dexamethasone 8.8915867202 16118317 15744524
MESH:D009101 Multiple Myeloma Paclitaxel 8.8914749477
MESH:D009101 Multiple Myeloma Raloxifene 8.8916497877
MESH:D009135 Muscular Diseases Gemfibrozil 5.1216239165
MESH:D009164 Mycobacterium Infections Isoniazid 14.0318474467
MESH:D009164 Mycobacterium Infections Rifampin 14.0318474467
MESH:D009164 Mycobacterium Infections Ritonavir 14.0321442799
MESH:D009181 Mycoses Amiodarone 4.1217974566 12754197
MESH:D009190 Myelodysplastic Syndromes Dexamethasone 5.879809623
MESH:D009190 Myelodysplastic Syndromes Tretinoin 5.8717596541
MESH:D009203 Myocardial Infarction Cocaine 5.0918072171
MESH:D009203 Myocardial Infarction Quercetin 5.0919595682
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.3912213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 6.5116810080
MESH:D015428 Myocardial Reperfusion Injury Quercetin 6.5119207477
MESH:D009207 Myoclonus Fluoxetine 5.118041377
MESH:D009224 Myotonia Congenita Carbamazepine 4.7020399394
MESH:D009232 Myxoma Raloxifene 4.7716343187
MESH:D009298 Nasal Polyps zafirlukast 5.6110665187 12053594
MESH:D009325 Nausea zafirlukast 5.0610386485
MESH:D009336 Necrosis zafirlukast 4.8015028970
MESH:D009362 Neoplasm Metastasis Paclitaxel 4.7015867366
MESH:D009362 Neoplasm Metastasis Tamoxifen 4.7019393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.2019410462
MESH:D009369 Neoplasms Quercetin 5.9715185748
MESH:D009369 Neoplasms Tetrachloroethylene 5.9711911487
MESH:D009369 Neoplasms Tretinoin 5.9716594593 16946489
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 3.2219189210 19196722 19200415
MESH:D009389 Neovascularization, Pathologic Estradiol 2.9717289903
MESH:D009395 Nephritis, Interstitial cinitapride 9.0418028853
MESH:D009395 Nephritis, Interstitial Ibuprofen 9.046375363
MESH:D009402 Nephrosis, Lipoid Cyclosporine 3.6617954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 2.6218481113 19348381
MESH:D009410 Nerve Degeneration Ibuprofen 3.7810961664
MESH:D009421 Nervous System Malformations Carbamazepine 17.5016990009
MESH:D009421 Nervous System Malformations Estradiol 17.5011399458 16427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 17.5014600291
MESH:D009421 Nervous System Malformations Tretinoin 17.509125849
MESH:D009436 Neural Tube Defects Tretinoin 2.529142499
MESH:D020078 Neurogenic Inflammation Quercetin 3.6517929310
MESH:D009503 Neutropenia Ritonavir 4.6617378895
MESH:D009771 Obsessive-Compulsive Disorder Fluoxetine 4.7420418887
MESH:D010003 Osteoarthritis Ibuprofen 3.627009135
MESH:D010014 Osteolysis Paclitaxel 4.2115867366
MESH:D010018 Osteomalacia Carbamazepine 4.7017016548
MESH:D010024 Osteoporosis Raloxifene 2.8817882678 15775268 19059307
MESH:D015663 Osteoporosis, Postmenopausal Quercetin 7.8219495926
MESH:D015663 Osteoporosis, Postmenopausal Raloxifene 7.8215579764 17823083 15758505 17893378
MESH:D010051 Ovarian Neoplasms Estradiol 8.6419401270
MESH:D010051 Ovarian Neoplasms Paclitaxel 8.6411161223
MESH:D010051 Ovarian Neoplasms Quercetin 8.6419005980
MESH:D010051 Ovarian Neoplasms Tretinoin 8.6416936753
MESH:D010146 Pain Carbamazepine 18.2915215642
MESH:D010146 Pain Fluoxetine 18.2912798668
MESH:D010146 Pain Ibuprofen 18.293291741
MESH:D010146 Pain montelukast 18.2915935457
MESH:D010146 Pain Tretinoin 18.2916870215
MESH:D010146 Pain zafirlukast 18.2911438310 15935457
MESH:D010149 Pain, Postoperative Ibuprofen 4.3616678543
MESH:D010190 Pancreatic Neoplasms Ibuprofen 6.7212384795
MESH:D010190 Pancreatic Neoplasms Quercetin 6.7216965848
MESH:D010190 Pancreatic Neoplasms Tretinoin 6.7215976015
MESH:D010195 Pancreatitis zafirlukast 4.2415028970
MESH:D016584 Panic Disorder Ethinyl Estradiol 2.9711578682
MESH:D010267 Parapsoriasis Carbamazepine 4.9416538176
OMIM:167400 PAROXYSMAL EXTREME PAIN DISORDER Carbamazepine 5.1517679678 17145499
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 3.4612520081
MESH:D010612 Pharyngitis zafirlukast 5.959377612 10386485
MESH:D020774 Pick Disease of the Brain Fluoxetine 5.248041377
MESH:D011085 Polycystic Ovary Syndrome Simvastatin 4.6517105841
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 2.8218163543
MESH:D011230 Precancerous Conditions 1-phenylazo-2-naphthol 11.782563599
MESH:D011230 Precancerous Conditions Cyclosporine 11.7812371664
MESH:D011230 Precancerous Conditions Quercetin 11.7819056647
MESH:D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma Dexamethasone 3.0621297632
MESH:D011248 Pregnancy Complications Carbamazepine 4.409014606
MESH:D011297 Prenatal Exposure Delayed Effects Carbamazepine 7.319014606
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 7.3111399792 11896295 11222880 11118676
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.1820887781
MESH:D011471 Prostatic Neoplasms Estradiol 1.9516740699
MESH:D011471 Prostatic Neoplasms Ibuprofen 1.9517409433
MESH:D011471 Prostatic Neoplasms Ketoconazole 1.9517404083
MESH:D011471 Prostatic Neoplasms Paclitaxel 1.9517136230 17172428 16356831 16729912
MESH:D011471 Prostatic Neoplasms Quercetin 1.9517292933 14715546
MESH:D011471 Prostatic Neoplasms Raloxifene 1.9515731164 16536755 16220300
MESH:D011471 Prostatic Neoplasms Tamoxifen 1.9515067354
MESH:D011507 Proteinuria Ibuprofen 11.606375363
MESH:D011507 Proteinuria pioglitazone 11.6016687628
MESH:D011507 Proteinuria Tretinoin 11.6016636307
MESH:D011537 Pruritus Ethinyl Estradiol 2.5515861022 16919318
MESH:D019310 Pseudolymphoma Carbamazepine 4.819591791 12752131
MESH:D011565 Psoriasis Cyclosporine 1.9016882103
MESH:D011618 Psychotic Disorders Cocaine 4.2316134406
MESH:D011625 Pterygium Tretinoin 4.0216723453
MESH:D029424 Pulmonary Disease, Chronic Obstructive zafirlukast 4.5812781059 12877822
MESH:D011654 Pulmonary Edema zafirlukast 4.8118309904
MESH:D011658 Pulmonary Fibrosis Amiodarone 4.9612490602 11597910 12832656
MESH:D011658 Pulmonary Fibrosis troglitazone 4.9618162602
MESH:D011693 Purpura Raloxifene 4.7715770314
MESH:D015427 Reperfusion Injury zafirlukast 3.9912967936
MESH:D012128 Respiratory Distress Syndrome, Adult Dexamethasone 3.3111700416 18379247
MESH:D012135 Respiratory Sounds Parathion 4.5511874814 17119214
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.1018990726
MESH:D012140 Respiratory Tract Diseases Parathion 4.7717119214
MESH:D012206 Rhabdomyolysis marker/mechanism
MESH:D012208 Rhabdomyosarcoma Tretinoin 3.3816116481 16283617
MESH:D012220 Rhinitis montelukast 7.4920332717
MESH:D012220 Rhinitis zafirlukast 7.4920332717 7767514 12742009
MESH:D012554 Schistosomiasis japonica Quercetin 4.7616862918
MESH:D012640 Seizures Carbamazepine 7.2115946322 9046859 16938433 16876388 19414003 9844417 16180713
MESH:D012640 Seizures Cocaine 7.2110454489
MESH:D012640 Seizures Isoniazid 7.2116107249
MESH:D020230 Serotonin Syndrome Fluoxetine 5.118704074
OMIM:609620 SHORT QT SYNDROME 1 Amiodarone 4.3118724381
MESH:D012852 Sinusitis zafirlukast 4.9110386485 10665187
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 4.1316192470
MESH:D012878 Skin Neoplasms Tretinoin 4.1316467112
MESH:D020181 Sleep Apnea, Obstructive montelukast 5.3819118273
MESH:D012893 Sleep Disorders Carbamazepine 4.3619414003
MESH:D013088 Spermatocele Ethinyl Estradiol 8.9616709447
MESH:D013088 Spermatocele Tamoxifen 8.9616709447
MESH:D013119 Spinal Cord Injuries montelukast 8.8818059327
MESH:D013119 Spinal Cord Injuries Tamoxifen 8.8819457130
MESH:D013262 Stevens-Johnson Syndrome Carbamazepine 4.4615057820 19915237 18855540 19694795 16415921 16538176 20485159
MESH:D013272 Stomach Diseases Dexamethasone 3.5615472012
MESH:D013274 Stomach Neoplasms Paclitaxel 3.0118396642 18506536
MESH:D013274 Stomach Neoplasms Tretinoin 3.0117261132
MESH:D013274 Stomach Neoplasms troglitazone 3.0115930296
MESH:D013276 Stomach Ulcer Amiodarone 15.3818087811
MESH:D013276 Stomach Ulcer cinitapride 15.389211565 9562338
MESH:D013276 Stomach Ulcer Dexamethasone 15.3815138204
MESH:D013276 Stomach Ulcer montelukast 15.3817895592
MESH:D013276 Stomach Ulcer Nifedipine 15.3814653237
MESH:D020521 Stroke Raloxifene 3.1916837676
MESH:D013610 Tachycardia Amiodarone 3.5611238279
MESH:D017180 Tachycardia, Ventricular Amiodarone 3.4619225199
MESH:D024801 Tauopathies Paclitaxel 4.0416930453
MESH:D019851 Thrombophilia Ethinyl Estradiol 2.9011994571
MESH:D013927 Thrombosis Ethinyl Estradiol 2.4915669648
MESH:D013959 Thyroid Diseases Amiodarone 16.6019731979
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 16.6012697716
MESH:D013959 Thyroid Diseases Thyroxine 16.6019910387
MESH:D013964 Thyroid Neoplasms Tretinoin 2.4317045167 16026305
MESH:D013971 Thyrotoxicosis Amiodarone 4.1018020914 19584973
MESH:D013978 Tibial Fractures Estradiol 11.1119048282
MESH:D013978 Tibial Fractures Raloxifene 11.1119048282
MESH:D014062 Tongue Neoplasms Tretinoin 3.1116051514
MESH:D016171 Torsades de Pointes Amiodarone 3.4311989578 17467628
MESH:D014376 Tuberculosis Isoniazid 10.5518397238 15236969 17720495 16770646 17950035 15673755
MESH:D014376 Tuberculosis Rifampin 10.5518397238 15236969
MESH:D014376 Tuberculosis Tretinoin 10.5516040207
MESH:D001749 Urinary Bladder Neoplasms Quercetin 6.2216720314
MESH:D001749 Urinary Bladder Neoplasms Raloxifene 6.2217572228
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 6.2216712894 17572228 8653321
MESH:D014581 Urticaria Loratadine 15.502568013
MESH:D014581 Urticaria montelukast 15.5010982225
MESH:D014581 Urticaria salmeterol 15.5010982225
MESH:D014581 Urticaria zafirlukast 15.5014512923 14713918
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 3.0016129372
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 2.5714692618
MESH:D014604 Uveal Neoplasms Tretinoin 3.8216752155
MESH:D014605 Uveitis Cyclosporine 9.171336536
MESH:D014605 Uveitis Dexamethasone 9.171336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 3.8112125929
MESH:D014657 Vasculitis zafirlukast 5.1412189465
MESH:D020301 Vasospasm, Intracranial Ibuprofen 9.6519057314
MESH:D020301 Vasospasm, Intracranial Nicardipine 9.6519057314
MESH:D054556 Venous Thromboembolism Raloxifene 4.4216837676
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 2.8414671159 15869587
MESH:D018487 Ventricular Dysfunction, Left torsemide 5.6118001696
MESH:D014820 Vitiligo Tretinoin 3.3216761959
MESH:D014846 Vulvar Neoplasms Raloxifene 4.7716343187
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 3.4615886252
MESH:D009396 Wilms Tumor Tretinoin 3.3016287080
MESH:D014985 Xerophthalmia Cyclosporine 3.6617120751
Pathway ID Pathway Name
KEGG:00590 Arachidonic acid metabolism
REACT:13433 Biological oxidations
KEGG:00982 Drug metabolism - cytochrome P450
KEGG:00591 Linoleic acid metabolism
KEGG:01100 Metabolic pathways
KEGG:00980 Metabolism of xenobiotics by cytochrome P450
KEGG:00830 Retinol metabolism
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA125
    • Releated gene ID Related gene Name
    PA125CYP2C8
    Releated disease ID Related disease Name
    PA444418Gastrointestinal Hemorrhage
    PA162263533nephrotoxicity
    PA445187Osteonecrosis
    PA445917Tremor
    PA443890Diabetes Mellitus, Type 2
    PA443622Carcinoma, Non-Small-Cell Lung
    PA444065Epilepsy
    PA445187Osteonecrosis
    PA443636Carotid Artery Diseases
    PA445549Rhabdomyolysis
    PA445019Myocardial Infarction
    PA447054Stroke
    PA443319Alzheimer Disease
    PA445062Neoplasms
    PA446108Colorectal Neoplasms
    PA444859Malaria
    PA443560Breast Neoplasms
    PA444818Lung Neoplasms
    PA445204Ovarian Neoplasms
    PA443937Drug Toxicity
    PA446975Neurotoxicity Syndromes
    Releated drug ID Related drug Name
    PA451799troglitazone
    PA164746334cilostazol
    PA451746tretinoin
    PA10816ezetimibe
    PA450128isotretinoin
    PA450595naproxen
    PA10384antiinflammatory and antirheumatic products, non-steroids
    PA448785carbamazepine
    PA450626nicotine
    PA162372877Nilotinib
    PA451578tacrolimus
    PA450767pamidronate
    PA10235zoledronate
    PA162360980meglitinides
    PA452609aflatoxin b1
    PA450262loperamide
    PA451627testosterone
    PA1658205851,7-dimethylxanthine
    PA448710caffeine
    PA451647theophylline
    PA448803carboplatin
    PA449383docetaxel
    PA164712468Antimalarials
    PA452631thiazolidinediones
    PA449247dexamethasone
    PA449552etoposide
    PA450496midazolam
    PA451611teniposide
    PA448500atorvastatin
    PA448897cerivastatin
    PA449167cyclosporine
    PA449334diltiazem
    PA449750gemfibrozil
    PA450272lovastatin
    PA142650384pitavastatin
    PA451089pravastatin
    PA451260ritonavir
    PA134308647rosuvastatin
    PA451868verapamil
    PA451283rosiglitazone
    PA450546montelukast
    PA451234repaglinide
    PA10202telithromycin
    PA452604xenobiotics
    PA451581tamoxifen
    PA452620tegafur
    PA448383amiodarone
    PA451788trimethoprim
    PA450970pioglitazone
    PA450761paclitaxel
    PA449957ibuprofen
    PA448404amodiaquine
    PA449165cyclophosphamide
    PA449412doxorubicin
    PA452621antineoplastic agents
    PA451250rifampin
    PA451668thiotepa
    PA449293diclofenac
    PA449493erythromycin
    PA449688fluvastatin
    PA449782glibenclamide
    PA450132itraconazole
    PA450146ketoconazole
    PA450268losartan
    PA451718tolbutamide
    PA451363simvastatin
    PA450911phenobarbital
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB03014 - Heme
    DB03796 - Palmitic Acid Enzyme Inhibitors
    DB08607 - (5R)-5-(4-{[(2R)-6-HYDROXY-2,5,7,8-TETRAMETHYL-3,4-DIHYDRO-2H-CHROMEN-2-YL]METHOXY}BENZYL)-1,3-THIAZOLIDINE-2,4-DIONE
    Drugbank ID Action Drug Name Description
    DB00091 inhibitor Cyclosporine Antirheumatic Agents;Immunomodulatory Agents;Enzyme Inhibitors;Dermatologic Agents;Immunosuppressive Agents;Antifungal Agents
    DB00169 inhibitor Women's Timed Release Ultra Mega Without Iron Essential Vitamin;Antihypocalcemic Agents;Antihypoparathyroid Agents;Vitamins (Vitamin D);Bone Density Conservation Agents;Vitamins
    DB00175 inhibitor Pravastatin Anticholesteremic Agents;HMG-CoA Reductase Inhibitors;Hydroxymethylglutaryl-CoA Reductase Inhibitors
    DB00184 substrate Nicotine Anti-craving Agents;Central Nervous System Agents;Autonomic drugs;Nicotinic Agonists;Ganglionic Stimulants
    DB00188 inhibitor Bortezomib Antineoplastic Agents;Protease Inhibitors
    DB00197 inhibitor Troglitazone Antineoplastic Agents;Hypoglycemic Agents;Vasodilator Agents;Platelet Aggregation Inhibitors;Fibrinolytic Agents
    DB00201 substrate Wigraine Tab Central Nervous System Stimulants;Anorexigenic Agents;Phosphodiesterase Inhibitors
    DB00205 inhibitor Sulfaquinoxaline-S Liq Antiprotozoals;Antimalarials;Folic Acid Antagonists;Antiprotozoal Agents
    DB00208 inhibitor Ticlopidine Platelet Aggregation Inhibitors;Fibrinolytic Agents
    DB00214 substrate Torasemide Antihypertensive Agents;Diuretics
    DB00227 inhibitor Lovastatin Antineoplastic Agents;Anticholesteremic Agents;HMG-CoA Reductase Inhibitors;Hydroxymethylglutaryl-CoA Reductase Inhibitors
    DB00231 substrate Temazepam Anti-anxiety Agents;Hypnotics and Sedatives;Benzodiazepines;Adjuvants, Anesthesia;GABA Modulators
    DB00250 substrate Dapsone Anti-Infective Agents;Anti-Infectives;Anti-inflammatory Agents;Antimalarials;Folic Acid Antagonists;Leprostatic Agents;Antimycobacterials
    DB00252 inducer Dilantin W Phenobarbital 30mg Cap Anticonvulsants
    DB00257 inhibitor Lotrisone Antifungal Agents;Anti-Infective Agents, Local;Growth Inhibitors
    DB00277 substrate Theophylline rougier elixir Vasodilator Agents;Phosphodiesterase Inhibitors;Bronchodilator Agents;Respiratory Smooth Muscle Relaxants
    DB00281 substrate Xylonor Spray Antiarrhythmic Agents;Anesthetics;Anesthetics, Local;Anti-Arrhythmia Agents
    DB00295 substrate Paregorique Narcotics;Analgesics;Opiate Agonists;Analgesics, Opioid
    DB00313 inhibitor Valproic Acid Anticonvulsants;Enzyme Inhibitors;Antimanic Agents;GABA Agents
    DB00316 substrate Zydone Analgesics, Non-Narcotic;Antipyretics
    DB00321 inhibitor Triavil Tab Adrenergic Uptake Inhibitors;Analgesics, Non-Narcotic;Antidepressive Agents, Tricyclic
    DB00333 substrate Methadone Narcotics;Analgesics;Opiate Agonists;Antitussives;Analgesics, Opioid;Antitussive Agents
    DB00338 substrate Omeprazole Anti-Ulcer Agents;Enzyme Inhibitors;Proton-pump Inhibitors
    DB00342 inhibitor Terfenadine Antiarrhythmic Agents;Anti-Allergic Agents;Antihistamines;Histamine H1 Antagonists, Non-Sedating
    DB00343 substrate Diltiazem Antihypertensive Agents;Vasodilator Agents;Calcium Channel Blockers;Cardiovascular Agents
    DB00347 substrate Trimethadione Anticonvulsants
    DB00359 substrate Sulfadiazine Anti-Infective Agents;Anti-Infectives;Antiprotozoals;Antiprotozoal Agents;Coccidiostats
    DB00363 substrate Clozapine Antipsychotics;Serotonin Antagonists;Antipsychotic Agents;GABA Antagonists
    DB00370 substrate Mirtazapine Histamine H1 Antagonists;Adrenergic alpha-Antagonists;Antidepressive Agents, Tricyclic
    DB00381 inhibitor Lotrel Antihypertensive Agents;Vasodilator Agents;Calcium Channel Blockers;Antianginals
    DB00396 substrate Synovex S Contraceptives;Progestins
    DB00398 inhibitor Sorafenib Antineoplastic Agents;Protein Kinase Inhibitors;Anticancer Agents
    DB00402 substrate Eszopiclone Hypnotics and Sedatives
    DB00412 inhibitor Avandaryl Hypoglycemic Agents;Vasodilator Agents;Fibrinolytic Agents;Thazolidinediones
    DB00418 inducer Secobarbital Hypnotics and Sedatives;Adjuvants, Anesthesia;GABA Modulators;Barbiturates;Adjuvants
    DB00421 inhibitor Novo-Spirozine-50 Tab Diuretics;Aldosterone Antagonists
    DB00439 inhibitor Cerivastatin Anticholesteremic Agents;Antilipemic Agents;Hydroxymethylglutaryl-CoA Reductase Inhibitors
    DB00440 inhibitor Trimethoprim Anti-Infectives;Antimalarials;Folic Acid Antagonists;Anti-Infective Agents, Urinary
    DB00446 inhibitor Zoomycetine Spray Anti-Bacterial Agents;Protein Synthesis Inhibitors
    DB00448 inhibitor Lansoprazole Anti-Infective Agents;Anti-Infectives;Anti-Ulcer Agents;Enzyme Inhibitors;Proton-pump Inhibitors
    DB00451 inhibitor Thyrolar Antithyroid Agents
    DB00455 inhibitor Liberator Antipruritics;Anti-Allergic Agents;Antihistamines;Histamine H1 Antagonists, Non-Sedating
    DB00468 inhibitor Triogene for Antimalarials;Analgesics, Non-Narcotic;Muscle Relaxants, Central
    DB00471 inhibitor Montelukast Anti-Asthmatic Agents;Antiarrhythmic Agents;Leukotriene Antagonists
    DB00481 inhibitor Raloxifene Antihypocalcemic Agents;Osteoporosis Prophylactic;Selective Estrogen Receptor Modulators;Estrogen Antagonists;Bone Density Conservation Agents
    DB00482 substrate Celecoxib Cyclooxygenase Inhibitors
    DB00495 substrate Trizivir Anti-HIV Agents;Antimetabolites;Nucleoside and Nucleotide Reverse Transcriptase Inhibitors;Reverse Transcriptase Inhibitors
    DB00501 inhibitor Cimetidine Anti-Ulcer Agents;Analgesics;Enzyme Inhibitors;Adjuvants;Histamine Antagonists;Histamine H2 Antagonists
    DB00503 inducer Kaletra Anti-HIV Agents;HIV Protease Inhibitors
    DB00514 substrate Tussin Cough Medicine Dm Antitussive Expectorant Decongestant Analgesics, Opioid;Antitussive Agents;Excitatory Amino Acid Antagonists
    DB00530 substrate Erlotinib Protein Kinase Inhibitors
    DB00531 inducer Procytox for Injection 2000mg Pws Iv Antineoplastic Agents;Antirheumatic Agents;Immunosuppressive Agents;Antineoplastic Agents, Alkylating;Myeloablative Agonists;Mutagens
    DB00532 substrate Mephenytoin Anticonvulsants
    DB00533 substrate Rofecoxib Cyclooxygenase Inhibitors;Cyclooxygenase 2 Inhibitors
    DB00544 substrate Fluorouracil Antineoplastic Agents;Antimetabolites;Immunosuppressive Agents;Antimetabolites, Antineoplastic
    DB00549 inhibitor Zafirlukast Anti-Asthmatic Agents;Leukotriene Antagonists
    DB00554 inhibitor Piroxicam Cyclooxygenase Inhibitors
    DB00564 inducer Carbamazepine Anticonvulsants;Analgesics;Antimanic Agents;Analgesics, Non-Narcotic
    DB00586 substrate Diclofenac Cyclooxygenase Inhibitors;Nonsteroidal Anti-inflammatory Agents (NSAIAs)
    DB00603 inhibitor Lunelle Contraceptives;Contraceptives, Oral, Synthetic;Progestins
    DB00604 substrate Cisapride Anti-Ulcer Agents;Gastrointestinal Agents;Serotonin Agonists;Prokinetic Agents
    DB00608 substrate Chloroquine Antirheumatic Agents;Antimalarials;Amebicides
    DB00613 substrate Camoprima Infatabs Antimalarials;Amebicides
    DB00617 substrate Paramethadione Anticonvulsants
    DB00622 inhibitor Nicardipine Antihypertensive Agents;Vasodilator Agents;Antiarrhythmic Agents;Calcium Channel Blockers;Dihydropyridines
    DB00624 substrate Uni-Bol Androgens
    DB00641 inhibitor Vytorin Anticholesteremic Agents;Antilipemic Agents;Hydroxymethylglutaryl-CoA Reductase Inhibitors
    DB00647 inhibitor Propoxyphene Narcotics;Analgesics;Antitussives;Analgesics, Opioid
    DB00661 substrate Tarka Vasodilator Agents;Antiarrhythmic Agents;Calcium Channel Blockers;Anti-Arrhythmia Agents
    DB00665 inhibitor Nilutamide Antineoplastic Agents;Androgen Antagonists
    DB00675 inhibitor Tamoxifen Antineoplastic Agents, Hormonal;Selective Estrogen Receptor Modulators;Estrogen Antagonists;Bone Density Conservation Agents
    DB00678 inhibitor Hyzaar Antihypertensive Agents;Angiotensin II Receptor Antagonists;Antiarrhythmic Agents;Angiotensin II Type 1 Receptor Blockers;Anti-Arrhythmia Agents
    DB00679 inhibitor Thioridazine Antipsychotics;Dopamine Antagonists;Phenothiazines;Antipsychotic Agents
    DB00682 inhibitor Warfarin Anticoagulants;Rodenticides;Coumarin and Indandione Derivatives
    DB00701 substrate Amprenavir Anti-HIV Agents;HIV Protease Inhibitors;Antibiotics, Antitubercular
    DB00705 inhibitor Delavirdine Anti-HIV Agents;Nonnucleoside Reverse Transcriptase Inhibitors;Reverse Transcriptase Inhibitors
    DB00715 inhibitor Paroxetine Antidepressants;Selective Serotonin Reuptake Inhibitors (SSRIs);Serotonin Uptake Inhibitors;Antidepressive Agents, Second-Generation
    DB00738 substrate Pentamidine Antifungal Agents;Trypanocidal Agents;Antiprotozoal Agents
    DB00741 inducer Vosol Hc Anti-inflammatory Agents
    DB00748 substrate Carbinoxamine Antihistamines
    DB00755 substrate Tretinoin Antineoplastic Agents;Keratolytic Agents;Cell Stimulants and Proliferants
    DB00758 inhibitor Clopidogrel Antiplatelet Agents;Platelet Aggregation Inhibitors;Fibrinolytic Agents
    DB00764 inhibitor Combisor Anti-inflammatory Agents;Anti-Allergic Agents
    DB00773 inhibitor Etoposide Nucleic Acid Synthesis Inhibitors;Antineoplastic Agents, Phytogenic
    DB00780 inhibitor Phenelzine Antidepressants;Antidepressive Agents;Monoamine Oxidase Inhibitors
    DB00783 substrate Triquilar 21 Anticholesteremic Agents;Estrogens;Anti-menopausal Agents
    DB00784 inhibitor Mefenamic acid Cyclooxygenase Inhibitors
    DB00788 substrate Naproxen Cyclooxygenase Inhibitors;Gout Suppressants
    DB00794 inducer Primidone Anticonvulsants;Barbiturates
    DB00796 inhibitor Atacand Plus Antihypertensive Agents;Angiotensin II Receptor Antagonists;Angiotensin II Type 1 Receptor Blockers
    DB00799 substrate Tazarotene Keratolytic Agents;Dermatologic Agents;Prodrugs;Teratogens
    DB00814 inhibitor Meloxicam Antineoplastic Agents;Cyclooxygenase Inhibitors;Antiemetics;Analgesics;Growth Inhibitors;Nonsteroidal Anti-inflammatory Agents (NSAIAs)
    DB00818 substrate Propofol Free Radical Scavengers;Hypnotics and Sedatives;Antiemetics;Anticonvulsants;Anesthetics, Intravenous
    DB00829 substrate Diazepam Anti-anxiety Agents;Hypnotics and Sedatives;Antiemetics;Anticonvulsants;Adjuvants, Anesthesia;GABA Modulators;Anesthetics, Intravenous;Muscle Relaxants, Central
    DB00835 substrate Tantapp Elixir Anti-Allergic Agents;Histamine H1 Antagonists
    DB00850 substrate Triavil Tab Antipsychotics;Dopamine Antagonists;Phenothiazines;Antipsychotic Agents
    DB00857 substrate Terbinafine Antifungals;Enzyme Inhibitors;Antifungal Agents;Trypanocidal Agents;Allylamines
    DB00897 inhibitor Triazolam Anti-anxiety Agents;Benzodiazepines;Adjuvants, Anesthesia;GABA Modulators
    DB00907 inhibitor Cocaine Vasoconstrictor Agents;Dopamine Uptake Inhibitors;Anesthetics;Local Anesthetics;Anesthetics, Local
    DB00908 substrate Quinidine Enzyme Inhibitors;Antiarrhythmic Agents;Antimalarials;Muscarinic Antagonists;Adrenergic alpha-Antagonists;Anti-Arrhythmia Agents
    DB00912 substrate Repaglinide Hypoglycemic Agents;Meglitinides
    DB00916 inhibitor Helidac Anti-Infective Agents;Anti-Infectives;Radiation-Sensitizing Agents;Antiprotozoals;Antiprotozoal Agents
    DB00921 substrate Buprenorphine Narcotics;Analgesics, Opioid;Narcotic Antagonists
    DB00938 inhibitor Advair 500 Diskus Bronchodilator Agents;Adrenergic beta-Agonists;Sympathomimetic
    DB00945 substrate Extra Strength Aspirin Backache Anticoagulants;Cyclooxygenase Inhibitors;Platelet Aggregation Inhibitors;Fibrinolytic Agents;Salicylates
    DB00946 substrate Phenprocoumon Anticoagulants
    DB00951 inhibitor Rifater Antitubercular Agents;Fatty Acid Synthesis Inhibitors
    DB00972 substrate Azelastine Lipoxygenase Inhibitors;Platelet Aggregation Inhibitors;Bronchodilator Agents;Anti-Allergic Agents;Histamine H1 Antagonists;Histamine H1 Antagonists, Non-Sedating
    DB00977 inhibitor Yasmin 28 Estrogens
    DB01007 inhibitor GyneCure Vaginal Ovules Tandempak Antifungal Agents
    DB01009 inhibitor Ketoprofen Anti-inflammatory Agents;Cyclooxygenase Inhibitors;Analgesics;Analgesics, Non-Narcotic;Antipyretics;Nonsteroidal Anti-inflammatory Agents (NSAIAs)
    DB01015 inhibitor Sulfamethoxazole and Trimethoprim Tablets Anti-Infective Agents;Anti-Infectives;Sulfonamides
    DB01023 inhibitor Lexxel Antihypertensive Agents;Vasodilator Agents;Calcium Channel Blockers;Dihydropyridines
    DB01026 inhibitor Ketoconazole Antifungals;Antifungal Agents
    DB01029 inhibitor Avalide 300/12.5 mg Antihypertensive Agents;Angiotensin II Receptor Antagonists;Angiotensin II Type 1 Receptor Blockers
    DB01032 inducer Probenecid Uricosuric Agents;Adjuvants, Pharmaceutic
    DB01037 substrate Selegiline Central Nervous System Agents;Antiparkinson Agents;Antidyskinetics;Neuroprotective Agents;Monoamine Oxidase Inhibitors;Dopaminergics
    DB01039 inhibitor Fenofibrate Antilipemic Agents;Fribic Acid Derivatives
    DB01045 inducer Rifater Enzyme Inhibitors;Antituberculosis Agents;Nucleic Acid Synthesis Inhibitors;Leprostatic Agents;Antibiotics;Antibiotics, Antitubercular
    DB01050 substrate Vicoprofen® Anti-inflammatory Agents;Cyclooxygenase Inhibitors;Analgesics;Analgesics, Non-Narcotic;Antipyretics;Nonsteroidal Anti-inflammatory Agents (NSAIAs)
    DB01062 inhibitor Oxybutynin Muscarinic Antagonists;Antispasmodics;Anticholinergic Agents;Parasympatholytics;Genitourinary Smooth Muscle Relaxants
    DB01076 inhibitor Caduet Anticholesteremic Agents;HMG-CoA Reductase Inhibitors;Hydroxymethylglutaryl-CoA Reductase Inhibitors
    DB01079 inhibitor Tegaserod Gastrointestinal Agents;Serotonin Agonists
    DB01095 inhibitor Fluvastatin Anticholesteremic Agents;HMG-CoA Reductase Inhibitors;Hydroxymethylglutaryl-CoA Reductase Inhibitors
    DB01097 inhibitor Leflunomide Antineoplastic Agents;Antirheumatic Agents;Antiviral Agents;Anti-inflammatory Agents;Enzyme Inhibitors;Immunosuppressive Agents;Antiparasitic Agents;Adjuvants
    DB01115 inhibitor Nifedipine Vasodilator Agents;Calcium Channel Blockers;Tocolytic Agents;Dihydropyridines
    DB01118 substrate Amiodarone Vasodilator Agents;Enzyme Inhibitors;Anti-Arrhythmia Agents
    DB01124 inhibitor Tolbutamide Hypoglycemic Agents;Sulfonylureas
    DB01132 inhibitor ActoplusMet Hypoglycemic Agents;Thazolidinediones
    DB01138 substrate Sulfinpyrazone Uricosuric Agents
    DB01156 substrate Bupropion Dopamine Uptake Inhibitors;Antidepressive Agents;Antidepressive Agents, Second-Generation
    DB01174 inducer Phenobarbital Hypnotics and Sedatives;Anticonvulsants;GABA Modulators;Excitatory Amino Acid Antagonists
    DB01181 inducer Ifosfamide Antineoplastic Agents;Immunosuppressive Agents;Antineoplastic Agents, Alkylating
    DB01182 inhibitor Propafenone Anti-Arrhythmia Agents
    DB01183 substrate Naloxone Antinarcotic Agents;Narcotic Antagonists;Depressants;Opiate Antagonists
    DB01184 substrate Domperidone Antiemetics;Dopamine Antagonists
    DB01198 substrate Zopiclone Hypnotics and Sedatives
    DB01201 inducer Rifapentine Leprostatic Agents;Antimycobacterials;Antibiotics, Antitubercular
    DB01218 substrate Halofantrine Antiprotozoals;Antimalarials
    DB01221 substrate Ketamine Analgesics;General Anesthetics;Excitatory Amino Acid Antagonists;Anesthetics, Dissociative
    DB01229 substrate Paclitaxel Antineoplastic Agents;Antineoplastic Agents, Phytogenic;Tubulin Modulators
    DB01232 inhibitor Saquinavir Anti-HIV Agents;HIV Protease Inhibitors
    DB01234 inducer Tresaderm Dermatologic Solution Anti-inflammatory Agents;Adrenergic Agents;Antiemetics;Antineoplastic Agents, Hormonal;Glucocorticoids
    DB01241 inducer Gemfibrozil Antilipemic Agents;Fribic Acid Derivatives
    DB01259 substrate Lapatinib Antineoplastic Agents;Protein Kinase Inhibitors
    DB01261 substrate Janumet Hypoglycemic Agents;Dipeptidyl-Peptidase IV Inhibitors
    DB01320 inducer Fosphenytoin Anticonvulsants
    DB01361 inhibitor Troleandomycin Anti-Bacterial Agents;Antibacterial Agents;Macrolides
    DB01393 inhibitor Hepaconda Antilipemic Agents
    DB01394 inducer Sucurnix HP Gout Suppressants;Tubulin Modulators
    DB01424 substrate Aminophenazone Analgesics;Pyrazolones
    DB01435 substrate Formule L2
    DB01583 inhibitor Liotrix Hormone Replacement Agents
    DB01698 inhibitor Rutin
    DB04216 inhibitor Quercetin Antioxidants
    DB04868 inhibitor Nilotinib Anticancer Agents
    DB06712 inhibitor Nilvadipine Antihypertensive Agents;Calcium Channel Blockers
    DB06716 substrate Fospropofol Hypnotics and Sedatives;Anesthetics, Intravenous
    DB06729 inhibitor Sulfaphenazole
    DB06772 substrate Cabazitaxel Antineoplastic Agents;Anticancer Agents
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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