AutismKB 2.0

Annotation Detail for ADRBK1


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Basic Information Top
Gene Symbol:ADRBK1 ( BARK1,BETA-ARK1,FLJ16718,GRK2 )
Gene Full Name: adrenergic, beta, receptor kinase 1
Band: 11q13.1
Quick LinksEntrez ID:156; OMIM: 109635; Uniprot ID:ARBK1_HUMAN; ENSEMBL ID: ENSG00000173020; HGNC ID:
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04144Endocytosis
hsa04062Chemokine signaling pathway
Pathway IDPathway Name
Signaling by GPCR
Signalling by NGF
Opioid Signalling
Pathway IDPathway Name
200019Signaling events mediated by HDAC Class II
200083CXCR4-mediated signaling events
200144Signaling events mediated by the Hedgehog family
Pathway IDPathway Name
P00026Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
P00049Parkinson disease
Pathway IDPathway Name
500436G alpha (q) signalling events
500634Calmodulin induced events
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1740Alzheimer's disease
2062Neurodegenerative disorder
No data
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of ADRBK1 mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of ADRBK1 mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen affects the expression of ADRBK1 mRNAaffects expression 17562736
D000643 Ammonium Chloride Ammonium Chloride affects the expression of ADRBK1 mRNAaffects expression 16483693
C095105 bexarotene bexarotene results in increased expression of ADRBK1 mRNAincreases expression 16648578
D004390 Chlorpyrifos Chlorpyrifos inhibits the reaction [ADRBK1 protein results in increased phosphorylation of CHRM2 protein]decreases reaction|increases phosphorylation 16824341
D004390 Chlorpyrifos Chlorpyrifos results in decreased expression of ADRBK1 mRNAdecreases expression 17452286
D003840 Deoxycholic Acid [gluconic acid co-treated with Deoxycholic Acid] results in increased expression of ADRBK1 mRNAaffects cotreatment|increases expression 16556975
D004026 Dieldrin Dieldrin results in increased expression of ADRBK1 mRNAincreases expression 18812211
D004837 Epinephrine Epinephrine promotes the reaction [ADRBK1 protein results in increased phosphorylation of ADRB2 protein]increases phosphorylation|increases reaction 14722251
C030691 gluconic acid [gluconic acid co-treated with Deoxycholic Acid] results in increased expression of ADRBK1 mRNAaffects cotreatment|increases expression 16556975
C120099 GW 1929 GW 1929 results in decreased expression of ADRBK1 mRNAdecreases expression 19420904
D009532 Nickel Nickel results in increased expression of ADRBK1 mRNAincreases expression 18812211
C511689 (N)-methanocarba-2MeSADP ADRBK1 protein inhibits the reaction [(N)-methanocarba-2MeSADP results in increased phosphorylation of and results in increased activity of AKT1 protein]decreases reaction|increases activity|increases phosphorylation 16236484
C009618 O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate inhibits the reaction [ADRBK1 protein results in increased phosphorylation of CHRM2 protein]decreases reaction|increases phosphorylation 16824341
D010656 Phenylephrine [Phenylephrine co-treated with ADRA1B protein] results in increased expression of ADRBK1 proteinaffects cotreatment|increases expression 11499749
C025643 vinclozolin vinclozolin affects the expression of ADRBK1 mRNAaffects expression 19015723
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 3.5818287403
MESH:D055371 Acute Lung Injury Nickel 4.5916166738
MESH:D000382 Agricultural Workers' Diseases Chlorpyrifos 4.3617119214 16611668 11874814
MESH:D000799 Angioedema Acetaminophen 3.8710982225
MESH:D001008 Anxiety Disorders vinclozolin 3.6419015723
MESH:D001145 Arrhythmias, Cardiac Phenylephrine 4.1117460149
MESH:D001172 Arthritis, Rheumatoid marker/mechanism 10094932
MESH:D001321 Autistic Disorder Acetaminophen 1.4218445737
MESH:D001919 Bradycardia Phenylephrine 4.5615306635
MESH:D001943 Breast Neoplasms bexarotene 2.2916818667 16344269
MESH:D001943 Breast Neoplasms Dieldrin 2.2915770527 11859874
MESH:D001943 Breast Neoplasms Nickel 2.2915986119
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 4.5116705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 4.5116705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 4.513084413
MESH:D002289 Carcinoma, Non-Small-Cell Lung bexarotene 3.2316247446
MESH:D006332 Cardiomegaly Phenylephrine 3.5316170337 11754973 17124262 15728586 17287366 11179087
MESH:D002386 Cataract Acetaminophen 2.5810977129
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 2.776135515
MESH:D003110 Colonic Neoplasms Deoxycholic Acid 3.5616213893
MESH:D003456 Cryptorchidism vinclozolin 4.3514966744
MESH:D003490 Cyanosis 2,4-dinitrotoluene 10.9418551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 10.9418551238
MESH:D017449 Dermatitis, Allergic Contact Nickel 3.9617100760 17244072 19470301
MESH:D003877 Dermatitis, Contact Nickel 4.642952479
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 6.1821346803 18551238
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 6.1821346803 18551238
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 6.1819739265 11739529 11287661 18713872 16177239 11743745 17906064 12540782 17522070 14550746 15968718 11529661 11421492 12153990 10915739 19416960 19164858 14725611 2444490 11461765 16109766 10663392 19923254 16781746 12594235 18071297 15619225 12705907 16393943 10774834 16485898 11834606 19370779 19085960 17562736 16081117 14986274 12392966 12958197 16227642 19420014
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.1319426721
MESH:D004827 Epilepsy Epinephrine 4.63821787
MESH:D005756 Gastritis Acetaminophen 3.7116983495
MESH:D030342 Genetic Diseases, Inborn vinclozolin 4.9516973722
MESH:D005832 Genital Diseases, Male vinclozolin 5.3316417039
MESH:D015658 HIV Infections Nickel 3.8217263646
MESH:D006930 Hyperalgesia Acetaminophen 2.7016870215
MESH:D006973 Hypertension Phenylephrine 3.0712717712 8949925
MESH:D006984 Hypertrophy Phenylephrine 4.5612791704 18502941
MESH:D007022 Hypotension Epinephrine 5.336740701
MESH:D007247 Infertility, Female Dieldrin 4.9410630421
MESH:D007248 Infertility, Male vinclozolin 3.0416467254
MESH:D007249 Inflammation Nickel 3.4216166738
MESH:D007674 Kidney Diseases Acetaminophen 2.2012587719 15629191
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 7.3716705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 7.3716705839
MESH:D007984 Leydig Cell Tumor vinclozolin 4.7516417039
MESH:D008107 Liver Diseases Acetaminophen 4.2616611625 19014921 12969438 16610002 19784758 11587558 19460945 12587719
MESH:D008107 Liver Diseases Chlorpyrifos 4.2615991261
MESH:D017114 Liver Failure, Acute Acetaminophen 3.2416871587 17185352
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 4.977678174
MESH:D008113 Liver Neoplasms Dieldrin 4.978742319 9539021
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 6.512876784 2876786 6135515
MESH:D008114 Liver Neoplasms, Experimental Deoxycholic Acid 6.516150874
MESH:D008175 Lung Neoplasms bexarotene 2.5217849452
MESH:D016410 Lymphoma, T-Cell, Cutaneous bexarotene 5.1611161223
MESH:D008325 Mammary Neoplasms, Experimental bexarotene 3.4115591091 19196723 19196722
MESH:D008546 Melanoma, Experimental Acetaminophen 3.5819513568
MESH:D009336 Necrosis 2,4-dinitrotoluene 10.4118551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 10.4118551238 7678174
MESH:D009369 Neoplasms Dieldrin 3.478820588
MESH:D009376 Neoplasms, Hormone-Dependent bexarotene 4.8119196722
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.8718514411
MESH:D020258 Neurotoxicity Syndromes Chlorpyrifos 4.1715081274
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 8.9012819281 16049721
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 8.9016049721
MESH:D010146 Pain Acetaminophen 2.3916870215
MESH:D010300 Parkinson Disease Dieldrin 3.5217291500 11181820 16809432 16112328 11445065
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 3.9218220299 18042343 19015723
MESH:D011469 Prostatic Diseases vinclozolin 4.9518220299
MESH:D011472 Prostatitis vinclozolin 4.9518629315
MESH:D012135 Respiratory Sounds Chlorpyrifos 4.6517119214 16611668 11874814
MESH:D012140 Respiratory Tract Diseases Chlorpyrifos 4.9216611668 17119214
MESH:D012640 Seizures 2,4-dinitrotoluene 5.8718551238
MESH:D012640 Seizures 2,6-dinitrotoluene 5.8718551238
MESH:D012729 Sex Chromosome Aberrations Chlorpyrifos 6.126418539
MESH:D012852 Sinusitis Phenylephrine 4.727327846
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 5.0116049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 5.0116049721
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 12.0610091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 12.0610091137
MESH:D014581 Urticaria Acetaminophen 2.9810982225
Pathway ID Pathway Name
KEGG:04062 Chemokine signaling pathway
KEGG:04144 Endocytosis
KEGG:04724 Glutamatergic synapse
REACT:15295 Opioid Signalling
REACT:14797 Signaling by GPCR
REACT:11061 Signalling by NGF
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA40
    • No data
    Releated disease ID Related disease Name
    PA444370Heart Failure
    PA444552Hypertension
    Releated drug ID Related drug Name
    PA164743471adenosine triphosphate
    PA449396dopamine
    PA164712535Beta Blocking Agents
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB00171 - Adenosine triphosphate Dietary supplement;Micronutrient
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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