AutismKB 2.0

Annotation Detail for CYP2C18


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Basic Information Top
Gene Symbol:CYP2C18 ( CPCI,CYP2C,CYP2C17,DKFZp686I24235,P450-6B/29C,P450IIC17 )
Gene Full Name: cytochrome P450, family 2, subfamily C, polypeptide 18
Band: 10q23.33
Quick LinksEntrez ID:1562; OMIM: 601131; Uniprot ID:CP2CI_HUMAN; ENSEMBL ID: ENSG00000108242; HGNC ID: 2620
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa00830Retinol metabolism
hsa00590Arachidonic acid metabolism
hsa00980Metabolism of xenobiotics by cytochrome P450
hsa00982Drug metabolism - cytochrome P450
hsa01100Metabolic pathways
hsa00591Linoleic acid metabolism
Pathway IDPathway Name
Biological oxidations
Pathway IDPathway Name
200194FOXA1 transcription factor network
No data
Pathway IDPathway Name
500197Xenobiotics
Related Diseases/Disorders Top
No data
No data
Desease Name
PHARMACOGENOMIC
Acenocoumarol maintenance dosage
Desease Name
Response to clopidogrel therapy
Acenocoumarol maintenance dosage
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C495657 1,1,1-trichloro-2-(4-hydroxyphenyl)-2-(4-methoxyphenyl)ethane CYP2C18 protein results in increased chemical synthesis of 1,1,1-trichloro-2-(4-hydroxyphenyl)-2-(4-methoxyphenyl)ethaneincreases chemical synthesis 9733665
C035342 1,4-naphthoquinone CYP2C18 protein results in increased abundance of 1,4-naphthoquinoneincreases abundance 16243959
C017062 1-benzylimidazole 1-benzylimidazole results in increased expression of CYP2C18 proteinincreases expression 16714371
D000074 Acenocoumarol CYP2C18 gene polymorphism affects the susceptibility to Acenocoumarolaffects response to substance 19578179
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of CYP2C18 proteinaffects expression 20106945
D019324 beta-Naphthoflavone beta-Naphthoflavone results in decreased expression of CYP2C18 mRNAdecreases expression 16985168
D003033 Coal Tar Coal Tar results in increased expression of CYP2C18 mRNAincreases expression 16882163
D016572 Cyclosporine Cyclosporine results in decreased expression of CYP2C18 mRNAdecreases expression 20106945
D008731 Methoxychlor CYP2C18 protein results in decreased methylation of Methoxychlordecreases methylation 9733665
D009853 Omeprazole Omeprazole results in increased expression of CYP2C18 proteinincreases expression 16714371
C023036 perfluorooctanoic acid perfluorooctanoic acid results in decreased expression of CYP2C18 mRNAdecreases expression 17560707
D010634 Phenobarbital Phenobarbital results in increased expression of CYP2C18 proteinincreases expression 9972451
D010634 Phenobarbital Phenobarbital results in increased expression of CYP2C18 proteinincreases expression 16714371
D011374 Progesterone Progesterone results in decreased expression of CYP2C18 mRNAdecreases expression 18070364
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of CYP2C18 mRNAdecreases expression 16985168
D014212 Tretinoin Tretinoin results in decreased expression of CYP2C18 mRNAdecreases expression 16985168
C060523 vorozole vorozole results in increased expression of CYP2C18 proteinincreases expression 16714371
D014859 Warfarin CYP2C18 gene polymorphism affects the susceptibility to Warfarinaffects response to substance 19752777
D014859 Warfarin CYP2C18 protein affects the susceptibility to Warfarinaffects response to substance 19752777
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 8.276195326
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 8.2715322242 14514962 11752688
MESH:D000236 Adenoma beta-Naphthoflavone 3.3219389873
MESH:D018248 Adenoma, Liver Cell Phenobarbital 10.0517620307
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 10.0516835633
MESH:D000505 Alopecia Tretinoin 3.6015955085
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.9311748828
MESH:D001169 Arthritis, Experimental Tretinoin 3.0616412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.2616292516
MESH:D001249 Asthma Tretinoin 2.3416456186
MESH:D001471 Barrett Esophagus Tretinoin 4.3916935849
MESH:D001778 Blood Coagulation Disorders Omeprazole 15.3319483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 15.3312125929
MESH:D001778 Blood Coagulation Disorders Tretinoin 15.3316206674 16197459
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.7915340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.7515746008
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 5.3417868700
MESH:D001930 Brain Injuries Progesterone 4.2415380490 15665606 15845082
MESH:D001943 Breast Neoplasms Progesterone 1.8615562024 16175315 17614352
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.8620435547
MESH:D001943 Breast Neoplasms Tretinoin 1.8616873071 16443354 16166294
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.5816813970
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.7816835633
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.1616168501
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 4.6121507988 12619106 12907637
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 4.6120935162 17173139 6705139 1701930 20007298
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 4.611917145
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 2.2816051514 16096774
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.3516120746 18850075 18670907
MESH:D002386 Cataract Tretinoin 3.0817460283
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 2.5112371664
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.244080065
MESH:D002543 Cerebral Hemorrhage Warfarin 5.8311061249
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.5816129372
MESH:D002637 Chest Pain Omeprazole 5.1115447763
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.1416835633
MESH:D002779 Cholestasis Cyclosporine 2.9019486331
MESH:D002822 Choriocarcinoma Tretinoin 5.1616461808
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 5.7412621046 15340226 16354765 8697196 15668235
MESH:D002972 Cleft Palate Tretinoin 5.749407595
MESH:D003092 Colitis Tretinoin 3.6917035595
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.0414669216 17141729
MESH:D023903 Coronary Restenosis Warfarin 5.6612872399
OMIM:122700 COUMARIN RESISTANCE Warfarin 5.8020497562 20579077
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.4415322242 10048152 20055451
MESH:D019465 Craniofacial Abnormalities Tretinoin 2.449142499 10589399 9125849 17551590 8800419 16925845 9664655 9211117 14991402 9224671
MESH:D003922 Diabetes Mellitus, Type 1 Warfarin 4.0518772604
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6617107852
MESH:D003928 Diabetic Nephropathies Warfarin 5.0712644472
MESH:D003929 Diabetic Neuropathies Progesterone 4.4817187935
MESH:D003875 Drug Eruptions Warfarin 5.9714723717
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 1.5320420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.7411462148
MESH:D004381 Duodenal Ulcer Omeprazole 4.3117151854 21218061 15991576 16613094
MESH:D004421 Dystonia Phenobarbital 3.991851702
MESH:D004487 Edema perfluorooctanoic acid 6.8817259670 12083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 6.8811000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 11.9516714409 15322242 18230668
MESH:D004489 Edema, Cardiac Tretinoin 11.9518230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 3.7617692515
MESH:D016889 Endometrial Neoplasms Tretinoin 3.0916569247
MESH:D004715 Endometriosis Progesterone 8.8716134523
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 8.879294722 10568697
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 4.093659116
MESH:D004828 Epilepsies, Partial Phenobarbital 3.873922381 11558140
MESH:D004827 Epilepsy Phenobarbital 2.8820417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.526401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 4.247750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 4.013659116
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 8.7811564622
MESH:D005124 Eye Abnormalities Tretinoin 8.789664655 16938888
MESH:D005234 Fatty Liver Cyclosporine 2.8419224547
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.4411858732
MESH:D005355 Fibrosis Cyclosporine 14.6512639820 12168785
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 14.6520067830
MESH:D005355 Fibrosis Tretinoin 14.6517994277
MESH:D006471 Gastrointestinal Hemorrhage Warfarin 6.7111794436
MESH:D005776 Gaucher Disease Warfarin 5.9412359135
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.218708960
MESH:D005909 Glioblastoma Tretinoin 2.9917312396
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.5910696789
MESH:D006258 Head and Neck Neoplasms Tretinoin 3.1716096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.1616084493
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.5010048152 11294989
MESH:D006330 Heart Defects, Congenital Tretinoin 6.5014991402 9664655
MESH:D006406 Hematoma Warfarin 6.7117493413
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.4115720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 10.4411000095
MESH:D006470 Hemorrhage Warfarin 10.4418429757
MESH:D006529 Hepatomegaly perfluorooctanoic acid 14.463609246
MESH:D006529 Hepatomegaly Phenobarbital 14.4616109766
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 14.4616120746 15340226 12621046
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.058697196 16354765 16959395 15340226 18606429
MESH:D006930 Hyperalgesia perfluorooctanoic acid 7.9912083418
MESH:D006930 Hyperalgesia Tretinoin 7.9916870215
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.5516778211
MESH:D006973 Hypertension Cyclosporine 4.9210903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 4.9218850075 18670907
MESH:D006976 Hypertension, Pulmonary Warfarin 4.7912359135
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 4.3915869954
MESH:D007248 Infertility, Male Methoxychlor 4.2211955947 16467254
MESH:D007249 Inflammation perfluorooctanoic acid 8.3312083418
MESH:D007249 Inflammation Progesterone 8.3315869954
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 8.3312200463 12878042
MESH:D007410 Intestinal Diseases Tretinoin 3.7517994277
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 9.8716580747
MESH:D007569 Jaw Abnormalities Tretinoin 9.8717551590 15992940
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.4415604871
MESH:D007674 Kidney Diseases Cyclosporine 2.338314463 10903974 18776723
MESH:D007680 Kidney Neoplasms Cyclosporine 2.7212371664
MESH:D016773 Leishmaniasis, Cutaneous Omeprazole 4.0819248655
MESH:D007938 Leukemia Tretinoin 2.7617143497
MESH:D007951 Leukemia, Myeloid Tretinoin 3.6819285840 16932348 16482212
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 2.0717596541 19850784 16294345
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 3.1417712046 19029980 19642359 19075265 17339181 19225113 17217047 12679006 16140955 16331271 17107899 17506722 17361223 16935935 16823087 15748426 17294898 16766008 16788101 17368321 19035177 17301526 9834237 17649720 16891316
MESH:D007984 Leydig Cell Tumor perfluorooctanoic acid 5.228812269
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.299224671
MESH:D054068 Livedo Reticularis Warfarin 6.7118280355
MESH:D008103 Liver Cirrhosis Phenobarbital 2.8821047994
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.3012878042
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 2.3018397230 16248980
MESH:D008107 Liver Diseases Phenobarbital 2.1719363144
MESH:D008113 Liver Neoplasms Aflatoxin B1 14.182125692 9163691 18177683 15890375
MESH:D008113 Liver Neoplasms beta-Naphthoflavone 14.1819389873 21295105
MESH:D008113 Liver Neoplasms perfluorooctanoic acid 14.1818709148 14757943
MESH:D008113 Liver Neoplasms Phenobarbital 14.188742319 19812893 19073162 19482888 21047994 15975961
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 14.1816984957
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 14.038603461
MESH:D008114 Liver Neoplasms, Experimental beta-Naphthoflavone 14.0318164116
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 14.031399818 18308698 2563599 6150874 17172636
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 14.0312151625
MESH:D008175 Lung Neoplasms Aflatoxin B1 2.2914755239
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 2.2911884234 19555203
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 2.8511408345 17203775
MESH:D008527 Medulloblastoma Tretinoin 2.7817453147
MESH:D008545 Melanoma Tretinoin 1.9416752155
MESH:D008591 Meningomyelocele Tretinoin 4.4116940565
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.7916801185
MESH:D009190 Myelodysplastic Syndromes Tretinoin 3.0717596541
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.0012213967
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.4717484760
MESH:D009336 Necrosis Warfarin 5.5414723717
MESH:D009369 Neoplasms Tretinoin 2.4016946489 16594593
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.4417954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.2719348381 18481113
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 9.4614600291
MESH:D009421 Nervous System Malformations Tretinoin 9.469125849
MESH:D009436 Neural Tube Defects Tretinoin 3.049142499
MESH:D052556 Niemann-Pick Disease, Type C perfluorooctanoic acid 4.949802331
MESH:D010018 Osteomalacia Phenobarbital 4.3617016548
MESH:D010051 Ovarian Neoplasms Progesterone 4.9016525653 17393432
MESH:D010051 Ovarian Neoplasms Tretinoin 4.9016936753
MESH:D010146 Pain Tretinoin 2.8816870215
MESH:D010190 Pancreatic Neoplasms Phenobarbital 5.2516965848
MESH:D010190 Pancreatic Neoplasms Tretinoin 5.2515976015
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.2512520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.5418163543
MESH:D011230 Precancerous Conditions Cyclosporine 8.9112371664
MESH:D011230 Precancerous Conditions Phenobarbital 8.912563599
MESH:D011297 Prenatal Exposure Delayed Effects perfluorooctanoic acid 9.6417132714
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 9.6411896295 11118676 11222880 11399792
MESH:D020151 Protein C Deficiency Warfarin 6.3418376272
MESH:D011507 Proteinuria Tretinoin 3.5916636307
MESH:D019310 Pseudolymphoma Phenobarbital 4.5012752131
MESH:D011565 Psoriasis Cyclosporine 2.2216882103
MESH:D011625 Pterygium Tretinoin 4.7816723453
MESH:D011655 Pulmonary Embolism Warfarin 6.3419300499
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.8218990726
MESH:D012208 Rhabdomyosarcoma Tretinoin 4.0816283617 16116481
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.8518045962
MESH:D012640 Seizures Phenobarbital 2.6811442880 3137016 4039156 16876388
MESH:D003294 Seizures, Febrile Phenobarbital 4.816407741
MESH:D012851 Sinus Thrombosis, Intracranial Warfarin 5.8512269725
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.5316192470
MESH:D012878 Skin Neoplasms Tretinoin 5.5316467112
MESH:D013119 Spinal Cord Injuries Progesterone 4.2715862959 16503802
MESH:D013272 Stomach Diseases Omeprazole 4.6018545984
MESH:D013274 Stomach Neoplasms Tretinoin 1.8017261132
MESH:D013276 Stomach Ulcer Omeprazole 3.7617977527 15991576 11906479 18237397 10750652 16755016
MESH:D020521 Stroke Warfarin 4.9619300499
MESH:D013923 Thromboembolism Acenocoumarol 14.1418698879
MESH:D013923 Thromboembolism Warfarin 14.1418698879 16960144
MESH:D019851 Thrombophilia Warfarin 5.5717493413
MESH:D013927 Thrombosis Warfarin 5.1019300499 17245631 11518727 15720958 17672075 11307788
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.9012697716
MESH:D013964 Thyroid Neoplasms Phenobarbital 7.141399818
MESH:D013964 Thyroid Neoplasms Tretinoin 7.1416026305 17045167
MESH:D014062 Tongue Neoplasms Tretinoin 3.7716051514
MESH:D014376 Tuberculosis Tretinoin 3.2116040207
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 3.6616129372
MESH:D014604 Uveal Neoplasms Tretinoin 4.6116752155
MESH:D014605 Uveitis Cyclosporine 3.981336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.5912125929
MESH:D014657 Vasculitis Warfarin 5.8520337814
MESH:D054556 Venous Thromboembolism Warfarin 6.3718776969
MESH:D020246 Venous Thrombosis Warfarin 5.4915733061 14723717
MESH:D014820 Vitiligo Tretinoin 4.0416761959
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.2515886252
MESH:D009396 Wilms Tumor Tretinoin 3.9516287080
MESH:D014985 Xerophthalmia Cyclosporine 4.4417120751
Pathway ID Pathway Name
KEGG:00590 Arachidonic acid metabolism
REACT:13433 Biological oxidations
KEGG:00982 Drug metabolism - cytochrome P450
KEGG:00591 Linoleic acid metabolism
KEGG:01100 Metabolic pathways
KEGG:00980 Metabolism of xenobiotics by cytochrome P450
KEGG:00830 Retinol metabolism
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA127
    • Releated gene ID Related gene Name
    PA127CYP2C18
    Releated disease ID Related disease Name
    PA443622Carcinoma, Non-Small-Cell Lung
    PA444818Lung Neoplasms
    PA444546Hypersensitivity
    PA443319Alzheimer Disease
    Releated drug ID Related drug Name
    PA449383docetaxel
    PA450947phenytoin
    PA452609aflatoxin b1
    PA450262loperamide
    PA451627testosterone
    PA452229antidepressants
    PA448710caffeine
    PA449061clozapine
    PA164713257Selective serotonin reuptake inhibitors
    PA452604xenobiotics
    PA451906warfarin
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB03014 - Heme
    DB07670 - 4-METHYL-N-METHYL-N-(2-PHENYL-2H-PYRAZOL-3-YL)BENZENESULFONAMIDE
    Drugbank ID Action Drug Name Description
    DB00250 substrate Dapsone Anti-Infective Agents;Anti-Infectives;Anti-inflammatory Agents;Antimalarials;Folic Acid Antagonists;Leprostatic Agents;Antimycobacterials
    DB00252 substrate Dilantin W Phenobarbital 30mg Cap Anticonvulsants
    DB00281 substrate Xylonor Spray Antiarrhythmic Agents;Anesthetics;Anesthetics, Local;Anti-Arrhythmia Agents
    DB00313 inhibitor Valproic Acid Anticonvulsants;Enzyme Inhibitors;Antimanic Agents;GABA Agents
    DB00333 substrate Methadone Narcotics;Analgesics;Opiate Agonists;Antitussives;Analgesics, Opioid;Antitussive Agents
    DB00338 substrate Omeprazole Anti-Ulcer Agents;Enzyme Inhibitors;Proton-pump Inhibitors
    DB00349 substrate Clobazam Anticonvulsants;Benzodiazepines
    DB00448 substrate Lansoprazole Anti-Infective Agents;Anti-Infectives;Anti-Ulcer Agents;Enzyme Inhibitors;Proton-pump Inhibitors
    DB00458 substrate Imipramine Adrenergic Uptake Inhibitors;Antidepressive Agents, Tricyclic;Norepinephrine-Reuptake Inhibitors
    DB00531 substrate Procytox for Injection 2000mg Pws Iv Antineoplastic Agents;Antirheumatic Agents;Immunosuppressive Agents;Antineoplastic Agents, Alkylating;Myeloablative Agonists;Mutagens
    DB00586 substrate Diclofenac Cyclooxygenase Inhibitors;Nonsteroidal Anti-inflammatory Agents (NSAIAs)
    DB00661 substrate Tarka Vasodilator Agents;Antiarrhythmic Agents;Calcium Channel Blockers;Anti-Arrhythmia Agents
    DB00682 substrate Warfarin Anticoagulants;Rodenticides;Coumarin and Indandione Derivatives
    DB00755 substrate Tretinoin Antineoplastic Agents;Keratolytic Agents;Cell Stimulants and Proliferants
    DB00818 substrate Propofol Free Radical Scavengers;Hypnotics and Sedatives;Antiemetics;Anticonvulsants;Anesthetics, Intravenous
    DB00829 substrate Diazepam Anti-anxiety Agents;Hypnotics and Sedatives;Antiemetics;Anticonvulsants;Adjuvants, Anesthesia;GABA Modulators;Anesthetics, Intravenous;Muscle Relaxants, Central
    DB00850 substrate Triavil Tab Antipsychotics;Dopamine Antagonists;Phenothiazines;Antipsychotic Agents
    DB00921 substrate Buprenorphine Narcotics;Analgesics, Opioid;Narcotic Antagonists
    DB01075 substrate Suppress Cough Syr W.Cod.Diphen.Hcl Amm.Chl. Hypnotics and Sedatives;Antiemetics;Antiparkinson Agents;Antidyskinetics;Antipruritics;Anesthetics;Anti-Allergic Agents;Histamine H1 Antagonists;Anesthetics, Local;Antitussives;Ethanolamine Derivatives
    DB01124 substrate Tolbutamide Hypoglycemic Agents;Sulfonylureas
    DB01151 substrate Desipramine Antidepressants;Adrenergic Uptake Inhibitors;Enzyme Inhibitors;Antidepressive Agents, Tricyclic;Norepinephrine-Reuptake Inhibitors
    DB01181 substrate Ifosfamide Antineoplastic Agents;Immunosuppressive Agents;Antineoplastic Agents, Alkylating
    DB01361 inhibitor Troleandomycin Anti-Bacterial Agents;Antibacterial Agents;Macrolides
    DB01424 substrate Aminophenazone Analgesics;Pyrazolones
    DB01435 substrate Formule L2
    DB01559 substrate Clotiazepam Anti-anxiety Agents;Hypnotics and Sedatives;Anticonvulsants;Benzodiazepines
    DB06716 substrate Fospropofol Hypnotics and Sedatives;Anesthetics, Intravenous
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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