AutismKB 2.0

Annotation Detail for CYP2D6


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Basic Information Top
Gene Symbol:CYP2D6 ( CPD6,CYP2D,CYP2D7AP,CYP2D7BP,CYP2D7P2,CYP2D8P2,CYP2DL1,CYPIID6,MGC120389,MGC120390,P450-DB1,P450C2D,P450DB1 )
Gene Full Name: cytochrome P450, family 2, subfamily D, polypeptide 6
Band: 22q13.2
Quick LinksEntrez ID:1565; OMIM: 124030; Uniprot ID:Q5Y7H2_HUMAN; ENSEMBL ID: ENSG00000100197; HGNC ID: 2625
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa00982Drug metabolism - cytochrome P450
No data
No data
No data
No data
Related Diseases/Disorders Top
No data
No data
Desease Name
CYP2D6 poor metabolizer phenotype
Parkinson's disease
CYP2D6 poor metabolizer phenotype.
simvastatin treatment, efficacy and tolerability
tamoxifen, prophylactic effect of
colorectal cancer
CARDIOVASCULAR
liver cancer
Alzheimer's disease
loratadine pharmacokinetics
CANCER
PSYCH
nortriptyline
liver disease
PHARMACOGENOMIC
breast cancer
hypertension
Haematological Neoplasias
personality disorders
amitriptyline
NEUROLOGICAL
Multiple System Atrophy
tardive dyskinesia
CYP2D7/CYP2D6 poor metabolizer phenotype.
schizophrenia
METABOLIC
depression
efficacy and tolerability of simvastatin
REPRODUCTION
patent ductus arteriosus
drug oxidation
haloperidol, plasma
No data
Desease Name
Debrisoquine sensitivity
Codeine sensitivity
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C495657 1,1,1-trichloro-2-(4-hydroxyphenyl)-2-(4-methoxyphenyl)ethane CYP2D6 protein results in increased hydroxylation of 1,1,1-trichloro-2-(4-hydroxyphenyl)-2-(4-methoxyphenyl)ethaneincreases hydroxylation 9047321
C439392 1-(2-methyl-4-methoxyphenyl)-4-((2-hydroxyethyl)amino)-6-trifluoromethoxy-2,3-dihydropyrrolo(3,2-c)quinoline CYP2D6 protein results in decreased methylation of 1-(2-methyl-4-methoxyphenyl)-4-((2-hydroxyethyl)amino)-6-trifluoromethoxy-2,3-dihydropyrrolo(3,2-c)quinolinedecreases methylation 15585365
C035342 1,4-naphthoquinone CYP2D6 protein results in increased abundance of 1,4-naphthoquinoneincreases abundance 16243959
C033020 1-aminobenzotriazole 1-aminobenzotriazole inhibits the reaction [CYP2D6 protein results in increased hydroxylation of bufuralol]decreases reaction|increases hydroxylation 15618748
C029350 1-naphthol CYP2D6 protein results in increased abundance of 1-naphtholincreases abundance 16243959
C024336 1-phenylazo-2-naphthol CYB5A protein inhibits the reaction [CYP2D6 protein results in increased oxidation of 1-phenylazo-2-naphthol]decreases reaction|increases oxidation 17159775
C024336 1-phenylazo-2-naphthol CYP2D6 protein results in increased oxidation of 1-phenylazo-2-naphtholincreases oxidation 17159775
C003898 2-anisidine CYP2D6 protein results in increased oxidation of 2-anisidineincreases oxidation 15828049
C109602 3-(2-(4-(3-chloro-2-methylphenyl)1-piperazinyl)ethyl)5,6-dimethoxy-1-(4-imidazolylmethyl)-1H-indazol dihydrochloride 3.5 hydrate 3-(2-(4-(3-chloro-2-methylphenyl)1-piperazinyl)ethyl)5,6-dimethoxy-1-(4-imidazolylmethyl)-1H-indazol dihydrochloride 3.5 hydrate results in decreased activity of CYP2D6 proteindecreases activity 16049129
C028657 3-methoxymorphinan CYP2D6 protein affects the metabolism of 3-methoxymorphinanaffects metabolic processing 15988119
C001470 4-ipomeanol CYP2D6 protein results in increased activity of 4-ipomeanolincreases activity 15892579
C016583 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone CYP2D6 protein results in increased metabolism of 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanoneincreases metabolic processing 2070484
C421010 9-(4'-aminophenyl)-9H-pyrido(3,4-b)indole CYP2D6 protein results in increased chemical synthesis of 9-(4'-aminophenyl)-9H-pyrido(3,4-b)indoleincreases chemical synthesis 15279827
C005709 ajmalicine ajmalicine inhibits the reaction [CYP2D6 protein affects the metabolism of Dextromethorphan]affects metabolic processing|decreases reaction 15930738
C005709 ajmalicine ajmalicine results in decreased activity of CYP2D6 proteindecreases activity 15930738
D000638 Amiodarone Amiodarone results in increased expression of CYP2D6 mRNAincreases expression 19774075
D000638 Amiodarone CYP2D6 gene polymorphism affects the reaction [Amiodarone results in increased abundance of Metoprolol]affects reaction|increases abundance 15541258
D000639 Amitriptyline CYP2D6 protein results in increased metabolism of Amitriptylineincreases metabolic processing 16044105
D000661 Amphetamine CYP2D6 protein affects the chemical synthesis of Amphetamineaffects chemical synthesis 15294457
D000662 Amphetamines CYP2D6 protein results in increased metabolism of Amphetaminesincreases metabolic processing 10911933
C023650 aniline CYP2D6 protein affects the metabolism of [norharman co-treated with aniline]affects cotreatment|affects metabolic processing 15279827
C041930 atomoxetine CYP2D6 protein results in increased hydroxylation of atomoxetineincreases hydroxylation 17470523
C061004 benidipine benidipine results in decreased activity of CYP2D6 proteindecreases activity 10805063
D001554 Benzene CYP2D6 gene polymorphism results in increased susceptibility to Benzeneincreases response to substance 17479406
16737584
D001554 Benzene CYP2D6 protein results in increased metabolism of Benzeneincreases metabolic processing 17479406
C400082 bortezomib CYP2D6 protein affects the metabolism of bortezomibaffects metabolic processing 15764713
C010831 bufuralol CYP2D6 protein affects the metabolism of bufuralolaffects metabolic processing 15801540
C010831 bufuralol 1-aminobenzotriazole inhibits the reaction [CYP2D6 protein results in increased hydroxylation of bufuralol]decreases reaction|increases hydroxylation 15618748
C010831 bufuralol CYP2D6 protein affects the metabolism of bufuralolaffects metabolic processing 15801540
C010831 bufuralol CYP2D6 protein results in increased hydrolysis of bufuralolincreases hydrolysis 11377097
C010831 bufuralol CYP2D6 protein results in increased hydroxylation of bufuralolincreases hydroxylation 9429232
10933885
15618748
12433797
15860655
17470523
C010831 bufuralol CYP2D6 protein results in increased metabolism of bufuralolincreases metabolic processing 12401345
12467917
12464242
16049126
C010831 bufuralol N-Methyl-3,4-methylenedioxyamphetamine inhibits the reaction [CYP2D6 protein results in increased metabolism of bufuralol]decreases reaction|increases metabolic processing 16049126
C010831 bufuralol Quinidine inhibits the reaction [CYP2D6 protein results in increased hydrolysis of bufuralol]decreases reaction|increases hydrolysis 11377097
C010831 bufuralol CYP2D6 protein affects the metabolism of bufuralolaffects metabolic processing 15801540
D002047 Buprenorphine Buprenorphine results in decreased activity of CYP2D6 proteindecreases activity 12756210
D002047 Buprenorphine CYP2D6 protein results in increased metabolism of Buprenorphineincreases metabolic processing 12756210
D002065 Buspirone CYP2D6 protein results in increased oxidation of Buspironeincreases oxidation 15640381
D002110 Caffeine CYP2D6 protein affects the metabolism of Caffeineaffects metabolic processing 15199075
C088453 Celsior Celsior results in decreased expression of CYP2D6 mRNAdecreases expression 15448115
D002738 Chloroquine CYP2D6 protein affects the metabolism of Chloroquineaffects metabolic processing 12920490
D002746 Chlorpromazine CYP2D6 protein results in increased metabolism of and results in increased activity of Chlorpromazineincreases activity|increases metabolic processing 19482014
D004390 Chlorpyrifos Chlorpyrifos results in increased expression of CYP2D6 mRNAincreases expression 16757081
D004390 Chlorpyrifos CYP2D6 protein results in increased oxidation of Chlorpyrifosincreases oxidation 14979094
D004390 Chlorpyrifos Quinine inhibits the reaction [CYP2D6 protein results in increased oxidation of Chlorpyrifos]decreases reaction|increases oxidation 14979094
D002927 Cimetidine Cimetidine inhibits the reaction [CYP2D6 protein results in increased metabolism of Dextromethorphan]decreases reaction|increases metabolic processing 17651725
D002927 Cimetidine Cimetidine results in decreased activity of CYP2D6 proteindecreases activity 17651725
C029010 cinnamic acid cinnamic acid analog results in decreased activity of CYP2D6 proteindecreases activity 15072549
D015283 Citalopram CYP2D6 protein results in decreased methylation of Citalopram analogdecreases methylation 9110356
D003024 Clozapine CYP2D6 protein affects the metabolism of Clozapineaffects metabolic processing 15286053
D003061 Codeine CYP2D6 gene polymorphism results in increased metabolism of Codeineincreases metabolic processing 17564651
D003061 Codeine CYP2D6 protein affects the metabolism of Codeineaffects metabolic processing 15286053
15625333
D003061 Codeine CYP2D6 protein results in decreased methylation of Codeinedecreases methylation 17470523
D003061 Codeine CYP2D6 protein results in increased metabolism of Codeineincreases metabolic processing 10911933
D003505 Cyclodextrins Cyclodextrins analog results in decreased activity of CYP2D6 proteindecreases activity 15665498
D003520 Cyclophosphamide CYP2D6 protein results in increased metabolism of Cyclophosphamideincreases metabolic processing 11377097
D003647 Debrisoquin CYP2D6 gene polymorphism results in decreased metabolism of Debrisoquindecreases metabolic processing 6603386
D003647 Debrisoquin CYP2D6 protein affects the metabolism of Debrisoquinaffects metabolic processing 3577206
D003647 Debrisoquin CYP2D6 protein results in increased hydroxylation of Debrisoquinincreases hydroxylation 17470523
D003647 Debrisoquin CYP2D6 protein results in increased metabolism of Debrisoquinincreases metabolic processing 12464242
D003671 DEET CYP2D6 protein results in increased metabolism of DEETincreases metabolic processing 11854147
C007278 desethylchloroquine desethylchloroquine results in decreased activity of CYP2D6 proteindecreases activity 11124226
D003891 Desipramine CYP2D6 protein affects the metabolism of Desipramineaffects metabolic processing 15286053
C121345 desloratadine CYP2D6 protein affects the chemical synthesis of desloratadineaffects chemical synthesis 15932952
D003917 Dextrorphan CYP2D6 protein affects the chemical synthesis of Dextrorphanaffects chemical synthesis 15988119
D003917 Dextrorphan CYP2D6 protein results in increased chemical synthesis of Dextrorphanincreases chemical synthesis 15155557
D003976 Diazinon Diazinon results in increased expression of CYP2D6 mRNAincreases expression 16757081
D004294 Domperidone CYP2D6 protein results in increased hydroxylation of Domperidoneincreases hydroxylation 15327587
C026013 fenproporex CYP2D6 protein results in decreased alkylation of fenproporexdecreases alkylation 15294457
D005473 Fluoxetine CYP2D6 protein affects the metabolism of Fluoxetineaffects metabolic processing 15286053
D005473 Fluoxetine CYP2D6 protein results in decreased methylation of Fluoxetinedecreases methylation 17470523
D005473 Fluoxetine Fluoxetine results in decreased activity of CYP2D6 proteindecreases activity 12173784
C419708 gefitinib CYP2D6 protein affects the metabolism of gefitinibaffects metabolic processing 15788367
D006220 Haloperidol CYP2D6 protein polymorphism affects the susceptibility to Haloperidolaffects response to substance 15538130
C058468 ICI 199441 ICI 199441 results in decreased activity of CYP2D6 proteindecreases activity 15863335
D007099 Imipramine CYP2D6 protein affects the metabolism of Imipramineaffects metabolic processing 15286053
C489645 indomethacin phenethylamide CYP2D6 protein results in increased metabolism of indomethacin phenethylamideincreases metabolic processing 14709628
D007510 Isatin Isatin results in increased expression of CYP2D6 mRNAincreases expression 15056799
D007559 Ivermectin Ivermectin results in decreased activity of CYP2D6 proteindecreases activity 11124226
D007654 Ketoconazole Ketoconazole results in decreased activity of CYP2D6 proteindecreases activity 15618748
D017336 Loratadine CYP2D6 gene polymorphism affects the metabolism of Loratadineaffects metabolic processing 15932952
D017336 Loratadine CYP2D6 protein affects the metabolism of Loratadineaffects metabolic processing 15932952
C054218 manidipine manidipine results in decreased activity of CYP2D6 proteindecreases activity 10805063
D008549 Melarsoprol Melarsoprol results in decreased activity of CYP2D6 proteindecreases activity 11124226
C050699 mepirodipine mepirodipine results in decreased activity of CYP2D6 proteindecreases activity 10805063
C006069 mequitazine CYP2D6 protein results in increased hydroxylation of mequitazineincreases hydroxylation 15863898
C006069 mequitazine Nicardipine inhibits the reaction [CYP2D6 protein results in increased hydroxylation of mequitazine]decreases reaction|increases hydroxylation 15863898
D003915 Dextromethorphan ajmalicine inhibits the reaction [CYP2D6 protein affects the metabolism of Dextromethorphan]affects metabolic processing|decreases reaction 15930738
D003915 Dextromethorphan CYP2D6 protein affects the metabolism of Dextromethorphanaffects metabolic processing 14586384
15199075
15286053
15025748
15988119
15626586
D003915 Dextromethorphan CYP2D6 protein results in decreased methylation of Dextromethorphandecreases methylation 15863898
17470523
12433797
D003915 Dextromethorphan CYP2D6 protein results in increased metabolism of Dextromethorphanincreases metabolic processing 17565714
15370959
15155557
17702393
10911933
16124035
9429232
17267297
17418993
D003915 Dextromethorphan Nicardipine inhibits the reaction [CYP2D6 protein results in decreased methylation of Dextromethorphan]decreases methylation|decreases reaction 15863898
D003915 Dextromethorphan Plant Extracts inhibits the reaction [CYP2D6 protein affects the metabolism of Dextromethorphan]affects metabolic processing|decreases reaction 15930738
D003915 Dextromethorphan serpentine (alkaloid) inhibits the reaction [CYP2D6 protein affects the metabolism of Dextromethorphan]affects metabolic processing|decreases reaction 15930738
D003915 Dextromethorphan Cimetidine inhibits the reaction [CYP2D6 protein results in increased metabolism of Dextromethorphan]decreases reaction|increases metabolic processing 17651725
D003915 Dextromethorphan CYP2D6 protein results in increased metabolism of Dextromethorphanincreases metabolic processing 17651725
D003915 Dextromethorphan ozagrel promotes the reaction [CYP2D6 protein results in increased metabolism of Dextromethorphan]increases metabolic processing|increases reaction 17651725
D018817 N-Methyl-3,4-methylenedioxyamphetamine CYP2D6 protein results in increased metabolism of N-Methyl-3,4-methylenedioxyamphetamineincreases metabolic processing 12464242
D018817 N-Methyl-3,4-methylenedioxyamphetamine N-Methyl-3,4-methylenedioxyamphetamine inhibits the reaction [CYP2D6 protein results in increased metabolism of bufuralol]decreases reaction|increases metabolic processing 16049126
D018817 N-Methyl-3,4-methylenedioxyamphetamine N-Methyl-3,4-methylenedioxyamphetamine results in decreased activity of CYP2D6 proteindecreases activity 16049126
D015632 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine CYP2D6 protein results in increased metabolism of 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridineincreases metabolic processing 12464242
D008790 Metoprolol CYP2D6 gene polymorphism affects the reaction [Amiodarone results in increased abundance of Metoprolol]affects reaction|increases abundance 15541258
D008790 Metoprolol CYP2D6 protein affects the metabolism of Metoprololaffects metabolic processing 15286053
15327588
D008790 Metoprolol CYP2D6 protein results in increased metabolism of Metoprololincreases metabolic processing 12464242
18979093
D009020 Morphine CYP2D6 protein affects the chemical synthesis of Morphineaffects chemical synthesis 15625333
D018721 Muscarinic Agonists CYP2D6 protein affects the metabolism of Muscarinic Agonistsaffects metabolic processing 16041192
D009529 Nicardipine CYP2D6 protein affects the metabolism of Nicardipineaffects metabolic processing 15863898
D009529 Nicardipine Nicardipine inhibits the reaction [CYP2D6 protein results in decreased methylation of Dextromethorphan]decreases methylation|decreases reaction 15863898
D009529 Nicardipine Nicardipine inhibits the reaction [CYP2D6 protein results in increased hydroxylation of mequitazine]decreases reaction|increases hydroxylation 15863898
D009529 Nicardipine Nicardipine results in decreased activity of CYP2D6 proteindecreases activity 15863898
10805063
D009534 Niclosamide Niclosamide results in decreased activity of CYP2D6 proteindecreases activity 11124226
C468271 N-methyl-N-benzylnitrosamine N-methyl-N-benzylnitrosamine results in decreased activity of CYP2D6 proteindecreases activity 12222751
C454677 N,N-diethyl-3-hydroxymethylbenzamide CYP2D6 protein results in increased chemical synthesis of N,N-diethyl-3-hydroxymethylbenzamideincreases chemical synthesis 11854147
C043585 norbuprenorphine norbuprenorphine results in decreased activity of CYP2D6 proteindecreases activity 12756210
C010262 norharman CYP2D6 protein affects the metabolism of [norharman co-treated with aniline]affects cotreatment|affects metabolic processing 15279827
C054116 norlevorphanol CYP2D6 protein affects the chemical synthesis of norlevorphanolaffects chemical synthesis 15988119
D009661 Nortriptyline CYP2D6 protein results in increased hydroxylation of Nortriptylineincreases hydroxylation 17470523
D017294 Ondansetron CYP2D6 protein affects the metabolism of Ondansetronaffects metabolic processing 15286053
D017294 Ondansetron CYP2D6 protein results in increased metabolism of Ondansetronincreases metabolic processing 12464242
C015408 oxatomide oxatomide results in decreased activity of CYP2D6 proteindecreases activity 15684493
C034364 ozagrel CYP2D6 protein results in increased metabolism of ozagrelincreases metabolic processing 17651725
C034364 ozagrel ozagrel promotes the reaction [CYP2D6 protein results in increased metabolism of Dextromethorphan]increases metabolic processing|increases reaction 17651725
C034364 ozagrel ozagrel results in increased expression of and results in increased activity of CYP2D6 proteinincreases activity|increases expression 17651725
D010278 Parathion CYP2D6 protein affects the metabolism of Parathionaffects metabolic processing 12669189
D017374 Paroxetine Paroxetine results in decreased activity of CYP2D6 proteindecreases activity 15860655
12173784
15632378
D010419 Pentamidine Pentamidine results in decreased activity of CYP2D6 proteindecreases activity 11124226
C023036 perfluorooctanoic acid perfluorooctanoic acid results in decreased expression of CYP2D6 mRNAdecreases expression 17681415
C031181 phenanthrene CYP2D6 protein results in increased metabolism of phenanthreneincreases metabolic processing 9429232
D010622 Phencyclidine CYP2D6 protein affects the metabolism of Phencyclidineaffects metabolic processing 16782764
D010936 Plant Extracts Plant Extracts inhibits the reaction [CYP2D6 protein affects the metabolism of Dextromethorphan]affects metabolic processing|decreases reaction 15930738
D010936 Plant Extracts Plant Extracts results in decreased activity of CYP2D6 proteindecreases activity 15992226
15974642
15930738
15900287
D010936 Plant Extracts Plant Extracts results in increased expression of CYP2D6 mRNAincreases expression 15629189
D010936 Plant Extracts Plant Extracts results in decreased activity of CYP2D6 proteindecreases activity 16033948
D011319 Primaquine CYP2D6 protein affects the metabolism of Primaquineaffects metabolic processing 12920490
D002727 Proguanil Proguanil results in decreased activity of CYP2D6 proteindecreases activity 11124226
D011433 Propranolol CYP2D6 protein affects the metabolism of Propranololaffects metabolic processing 15286053
D011433 Propranolol CYP2D6 protein results in increased metabolism of Propranololincreases metabolic processing 12464242
D011715 Pyrantel CYP2D6 protein affects the metabolism of Pyrantelaffects metabolic processing 12920490
D011802 Quinidine CYP2D6 protein results in increased metabolism of Quinidineincreases metabolic processing 17702393
D011802 Quinidine Quinidine inhibits the reaction [CYP2D6 protein results in increased hydrolysis of bufuralol]decreases reaction|increases hydrolysis 11377097
D011802 Quinidine Quinidine inhibits the reaction [CYP2D6 protein results in increased metabolism of tegaserod]decreases reaction|increases metabolic processing 11560869
D011802 Quinidine Quinidine results in decreased activity of CYP2D6 proteindecreases activity 15155557
12464242
8819299
12467917
12814958
16035375
15860655
15306208
D011802 Quinidine Quinidine results in decreased activity of CYP2D6 proteindecreases activity 10828259
D011803 Quinine Quinine inhibits the reaction [CYP2D6 protein results in increased oxidation of Chlorpyrifos]decreases reaction|increases oxidation 14979094
D012293 Rifampin Rifampin results in increased expression of CYP2D6 mRNAincreases expression 19041851
D018967 Risperidone CYP2D6 protein affects the metabolism of Risperidoneaffects metabolic processing 15669884
D018967 Risperidone CYP2D6 protein polymorphism affects the susceptibility to Risperidoneaffects response to substance 15669884
D018967 Risperidone CYP2D6 protein results in increased metabolism of Risperidoneincreases metabolic processing 16044105
D019438 Ritonavir CYP2D6 protein affects the metabolism of Ritonaviraffects metabolic processing 15286053
C039685 Ro 03-7410 CYP2D6 protein results in increased chemical synthesis of Ro 03-7410increases chemical synthesis 12401345
C089730 rosiglitazone rosiglitazone results in decreased activity of CYP2D6 proteindecreases activity 12642470
D012451 Safrole Safrole results in decreased activity of CYP2D6 proteindecreases activity 15778010
C009244 serpentine (alkaloid) serpentine (alkaloid) inhibits the reaction [CYP2D6 protein affects the metabolism of Dextromethorphan]affects metabolic processing|decreases reaction 15930738
C009244 serpentine (alkaloid) serpentine (alkaloid) results in decreased activity of CYP2D6 proteindecreases activity 15930738
D020280 Sertraline CYP2D6 protein results in decreased methylation of and results in increased metabolism of Sertralinedecreases methylation|increases metabolic processing 15547048
D013034 Sparteine CYP2D6 protein results in increased metabolism of Sparteineincreases metabolic processing 11907490
D013629 Tamoxifen CYP2D6 gene affects the abundance of and affects the susceptibility to Tamoxifenaffects abundance|affects response to substance 20124171
D013629 Tamoxifen CYP2D6 gene polymorphism affects the susceptibility to Tamoxifenaffects response to substance 19189212
19189210
D013629 Tamoxifen CYP2D6 gene polymorphism results in decreased susceptibility to Tamoxifendecreases response to substance 20309015
D013629 Tamoxifen CYP2D6 gene polymorphism results in increased susceptibility to Tamoxifenincreases response to substance 21152245
D013629 Tamoxifen CYP2D6 protein affects the metabolism of Tamoxifenaffects metabolic processing 15632378
19189212
15961252
D013629 Tamoxifen CYP2D6 protein results in increased metabolism of Tamoxifenincreases metabolic processing 20123649
D013629 Tamoxifen CYP2D6 protein results in increased susceptibility to Tamoxifenincreases response to substance 19244106
D013629 Tamoxifen Tamoxifen results in increased expression of CYP2D6 proteinincreases expression 19812351
C105050 tegaserod CYP2D6 protein results in increased metabolism of tegaserodincreases metabolic processing 11560869
C105050 tegaserod Quinidine inhibits the reaction [CYP2D6 protein results in increased metabolism of tegaserod]decreases reaction|increases metabolic processing 11560869
C105050 tegaserod tegaserod results in decreased activity of CYP2D6 proteindecreases activity 11560869
D013881 Thioridazine CYP2D6 protein results in increased metabolism of and results in increased activity of Thioridazineincreases activity|increases metabolic processing 19482014
D013988 Ticlopidine Ticlopidine results in decreased activity of CYP2D6 proteindecreases activity 10759690
D014147 Tramadol CYP2D6 gene mutant form affects the metabolism of Tramadolaffects metabolic processing 12191703
D014147 Tramadol CYP2D6 gene polymorphism affects the metabolism of Tramadolaffects metabolic processing 18520597
17570739
D014147 Tramadol CYP2D6 gene polymorphism affects the susceptibility to Tramadolaffects response to substance 16497087
D014147 Tramadol CYP2D6 gene polymorphism results in decreased susceptibility to Tramadoldecreases response to substance 16960721
D014147 Tramadol CYP2D6 protein affects the susceptibility to Tramadolaffects response to substance 16960721
D014147 Tramadol CYP2D6 protein results in decreased methylation of Tramadoldecreases methylation 14624403
17470523
17361124
D014147 Tramadol CYP2D6 protein results in increased metabolism of Tramadolincreases metabolic processing 18520597
18204346
18713907
D014147 Tramadol CYP2D6 protein affects the methylation of Tramadolaffects methylation 12893130
C507866 trans-1,2-dihydro-1,2-naphthalenediol CYP2D6 protein results in increased abundance of trans-1,2-dihydro-1,2-naphthalenediolincreases abundance 16243959
C047426 venlafaxine CYP2D6 gene mutant form affects the metabolism of venlafaxineaffects metabolic processing 18214456
10774634
C047426 venlafaxine CYP2D6 gene polymorphism affects the metabolism of venlafaxineaffects metabolic processing 16958828
C047426 venlafaxine CYP2D6 gene polymorphism affects the methylation of venlafaxineaffects methylation 10877013
10933885
C047426 venlafaxine CYP2D6 protein affects the susceptibility to venlafaxineaffects response to substance 17803873
C047426 venlafaxine CYP2D6 protein results in decreased methylation of venlafaxinedecreases methylation 10877013
10933885
C047426 venlafaxine CYP2D6 protein results in increased metabolism of venlafaxineincreases metabolic processing 16958828
10774634
18214456
16044105
C047426 venlafaxine venlafaxine results in decreased activity of CYP2D6 proteindecreases activity 15632378
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 3.6314745880
MESH:D000236 Adenoma 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone 3.2916176798
MESH:D000380 Agranulocytosis Clozapine 4.1816160616 14617031 12649775
MESH:D000382 Agricultural Workers' Diseases Chlorpyrifos 9.6316611668 11874814 17119214
MESH:D000382 Agricultural Workers' Diseases Diazinon 9.6316487989
MESH:D000382 Agricultural Workers' Diseases Parathion 9.6311874814 17119214
MESH:D017088 AIDS-Related Opportunistic Infections Pentamidine 5.4511806628
MESH:D000437 Alcoholism Ondansetron 5.4819032576
OMIM:607154 ALLERGIC RHINITIS Loratadine 4.9316527031
MESH:D000544 Alzheimer Disease Plant Extracts 3.6816962711
MESH:D000544 Alzheimer Disease rosiglitazone 3.6819621015
MESH:D019969 Amphetamine-Related Disorders Amphetamine 5.1616459022 15010207 18475255 16916582
MESH:D000741 Anemia, Aplastic Benzene 3.6411369114 17661222 14761424
MESH:D000855 Anorexia Amphetamine 8.0112183048 16084549 12005258 16101753
MESH:D000855 Anorexia N-Methyl-3,4-methylenedioxyamphetamine 8.0115146954
MESH:D001008 Anxiety Disorders Citalopram 11.1218083778
MESH:D001008 Anxiety Disorders Fluoxetine 11.1218083778
MESH:D001008 Anxiety Disorders Sertraline 11.1218822694
MESH:D001145 Arrhythmias, Cardiac Amiodarone 6.8918218290 18057881 20041841
MESH:D001145 Arrhythmias, Cardiac Quinidine 6.8918724381 18057881
MESH:D001161 Arteriosclerosis Cyclophosphamide 8.4415014928
MESH:D001161 Arteriosclerosis indomethacin phenethylamide 8.4415950196
MESH:D001169 Arthritis, Experimental Plant Extracts 3.3314686799
MESH:D020817 Asperger Syndrome Risperidone 4.7016401163
MESH:D001249 Asthma Loratadine 3.899196086
MESH:D001281 Atrial Fibrillation Amiodarone 3.1919698954 18651412
MESH:D001289 Attention Deficit Disorder with Hyperactivity atomoxetine 10.4017069549 17003665 17069548
MESH:D001289 Attention Deficit Disorder with Hyperactivity Dextromethorphan 10.4017175572
MESH:D001289 Attention Deficit Disorder with Hyperactivity Risperidone 10.4018349709
MESH:D001321 Autistic Disorder atomoxetine 5.5819232924
MESH:D001321 Autistic Disorder Buspirone 5.5818056831
MESH:D001321 Autistic Disorder Citalopram 5.5818775368 19232924
MESH:D001321 Autistic Disorder Fluoxetine 5.5819232924 18775368
MESH:D001321 Autistic Disorder Haloperidol 5.5818080171 19368416
MESH:D001321 Autistic Disorder Propranolol 5.5818766980
MESH:D001321 Autistic Disorder Risperidone 5.5816239862 15543515 19368416 19154706 18026891 17019624 16379507 16730335 17069546 16601648 19232924 18080171 15492353 15930063 17929164 15994720 18349709 19013209 18278980 18775368 16948927
MESH:D001321 Autistic Disorder Sertraline 5.5818775368
MESH:D001714 Bipolar Disorder Risperidone 3.9719154706 18278980
MESH:D001778 Blood Coagulation Disorders Amiodarone 3.0919483382
MESH:D001855 Bone Marrow Diseases Benzene 4.3216183116
MESH:D001919 Bradycardia Propranolol 4.686740701
MESH:D002545 Brain Ischemia Morphine 7.8319211983
MESH:D002545 Brain Ischemia Plant Extracts 7.8316041641
MESH:D001943 Breast Neoplasms marker/mechanism 19597703
MESH:D001943 Breast Neoplasms 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone 1.9920146248
MESH:D001943 Breast Neoplasms Benzene 1.9911921183 17162533
MESH:D001943 Breast Neoplasms Cyclophosphamide 1.9915136595 18234424 12006526 17388661 15093573 17020986 18323546 11325840 16978400
MESH:D001943 Breast Neoplasms Parathion 1.9912762645
MESH:D001943 Breast Neoplasms Tamoxifen 1.9918855134 15565566 19289846 19221464 19066611 18629630 19410462 19155303 18425577 16202921 18984771 20544844 16273361 19142967 16818667 19189210 17440819 19189212 19487384 19115204 18997820 11161223 20005174 18815881 18821012 17893378 16873071 20135344 17049068 15668708 19244106 19011961 19059307 21152245 20065188 19200415 21138602 17261762 19103187 20390343 17242785 19084267 18351453 19288272 20859285
MESH:D002057 Burns, Chemical Plant Extracts 4.429625245
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 3.6319066611
MESH:D006528 Carcinoma, Hepatocellular Cyclophosphamide 3.5319701751
MESH:D006528 Carcinoma, Hepatocellular Plant Extracts 3.5318834353
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 3.5316924424
MESH:D018827 Carcinoma, Lewis Lung Cyclophosphamide 4.0016152834
MESH:D002289 Carcinoma, Non-Small-Cell Lung bortezomib 5.0616052434
MESH:D002289 Carcinoma, Non-Small-Cell Lung gefitinib 5.0616230376 20005069 17290066 15496427 19233551 18347146
MESH:D002292 Carcinoma, Renal Cell Cyclophosphamide 3.0316201981
MESH:D002294 Carcinoma, Squamous Cell N-methyl-N-benzylnitrosamine 4.5212222751
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 2.8217572228
MESH:D006332 Cardiomegaly Plant Extracts 3.2317645561
MESH:D002311 Cardiomyopathy, Dilated Amiodarone 5.2319225199 15710769
MESH:D002311 Cardiomyopathy, Dilated Metoprolol 5.2319477965
MESH:D002341 Carotid Artery Thrombosis Amiodarone 4.1918974383
MESH:D002375 Catalepsy Haloperidol 4.021977408 15215559
MESH:D002653 Child Behavior Disorders Dextromethorphan 6.3217175572
MESH:D002659 Child Development Disorders, Pervasive Citalopram 4.1415782081
MESH:D016770 Ciliophora Infections Niclosamide 8.4412113305
MESH:D016770 Ciliophora Infections Quinine 8.4412113305
MESH:D003072 Cognition Disorders Clozapine 4.0917123785
MESH:D015179 Colorectal Neoplasms gefitinib 3.2617594712
MESH:D003324 Coronary Artery Disease Ticlopidine 4.6519432301
MESH:D003371 Cough Dextromethorphan 5.2317323712
MESH:D019465 Craniofacial Abnormalities Benzene 2.4215643154
MESH:D003556 Cystitis Cyclophosphamide 4.0810498854 12161096 16614059 17979934 15276878 16989017 18372110 12913760 12388444 18483878 18093676 11948286 15643279 18710439 16413132 18433785 10700343 16651033 18295254 17010015
MESH:D016757 Death, Sudden, Cardiac Haloperidol 13.7620210726
MESH:D016757 Death, Sudden, Cardiac Risperidone 13.7620210726
MESH:D016757 Death, Sudden, Cardiac Thioridazine 13.7620210726
MESH:D003704 Dementia Haloperidol 12.2311575062
MESH:D003704 Dementia Risperidone 12.2311575062
MESH:D003704 Dementia Thioridazine 12.2311575062
MESH:D003711 Demyelinating Diseases Tamoxifen 3.4819031437
MESH:D003866 Depressive Disorder Amitriptyline 30.1915014590 18083778
MESH:D003866 Depressive Disorder Citalopram 30.1915014590
MESH:D003866 Depressive Disorder Desipramine 30.193690436 15014590
MESH:D003866 Depressive Disorder Fluoxetine 30.1915014590
MESH:D003866 Depressive Disorder Imipramine 30.1920305041
MESH:D003866 Depressive Disorder Paroxetine 30.1917072103 15014590
MESH:D003866 Depressive Disorder Sertraline 30.1915014590 20305041 18822694
MESH:D003866 Depressive Disorder venlafaxine 30.1920305041
MESH:D003865 Depressive Disorder, Major Sertraline 4.5816968574
MESH:D003872 Dermatitis Benzene 3.8915902427
MESH:D002658 Developmental Disabilities atomoxetine 5.3417069548 17069549
MESH:D003920 Diabetes Mellitus rosiglitazone 3.5217446233
MESH:D003921 Diabetes Mellitus, Experimental Cyclophosphamide 3.3210990075 15331540 11751995
MESH:D003922 Diabetes Mellitus, Type 1 Cyclophosphamide 2.8618772604
MESH:D003924 Diabetes Mellitus, Type 2 benidipine 5.6616387788
MESH:D003924 Diabetes Mellitus, Type 2 Clozapine 5.6616402076
MESH:D003924 Diabetes Mellitus, Type 2 rosiglitazone 5.6612642470
MESH:D003928 Diabetic Nephropathies Plant Extracts 6.6219706694
MESH:D003928 Diabetic Nephropathies Tamoxifen 6.6219279558
MESH:D003967 Diarrhea Codeine 9.267237001
MESH:D003967 Diarrhea Morphine 9.262540324
MESH:D003967 Diarrhea Ondansetron 9.2610867622
MESH:D006970 Disorders of Excessive Somnolence Clozapine 11.4215331141
MESH:D006970 Disorders of Excessive Somnolence Risperidone 11.4216379507
MESH:D053207 Diurnal Enuresis Risperidone 5.7617822346
MESH:D004314 Down Syndrome Risperidone 4.3718349709
MESH:D056486 Drug-Induced Liver Injury Amiodarone 6.1315265979 18218290
MESH:D056486 Drug-Induced Liver Injury Chlorpromazine 6.1311461765
MESH:D056486 Drug-Induced Liver Injury Ketoconazole 6.1318289764
MESH:D056486 Drug-Induced Liver Injury Ritonavir 6.1314986274
OMIM:608902 DRUG METABOLISM, POOR, CYP2D6-RELATED marker/mechanism
MESH:D004409 Dyskinesia, Drug-Induced Desipramine 5.273690436
MESH:D050171 Dyslipidemias Clozapine 3.4916402076
MESH:D004417 Dyspnea Diazinon 3.9016487989
MESH:D004487 Edema Amitriptyline 20.4312798668
MESH:D004487 Edema Cimetidine 20.4319703484
MESH:D004487 Edema Fluoxetine 20.4312798668
MESH:D004487 Edema Imipramine 20.4312798668
MESH:D004487 Edema perfluorooctanoic acid 20.4312083418 17259670
MESH:D004487 Edema Plant Extracts 20.4312787963
MESH:D004487 Edema rosiglitazone 20.4312083418
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 2.7019031437
MESH:D016889 Endometrial Neoplasms Tamoxifen 2.4019155303 16202921 17893378 20544844
MESH:D004719 Endomyocardial Fibrosis Plant Extracts 4.7715268973
MESH:D004802 Eosinophilia Cyclophosphamide 3.3611006010
MESH:D004827 Epilepsy Plant Extracts 3.1919439326 19700373
MESH:D004830 Epilepsy, Tonic-Clonic marker/mechanism 16835697
MESH:D004938 Esophageal Neoplasms N-methyl-N-benzylnitrosamine 4.5112222751
MESH:D005221 Fatigue Amphetamine 4.7019890266
MESH:D005234 Fatty Liver Amiodarone 12.2814986274
MESH:D005234 Fatty Liver Plant Extracts 12.2815975614
MESH:D005234 Fatty Liver rosiglitazone 12.2819196556
MESH:D005234 Fatty Liver Tamoxifen 12.2814986274 19224547
MESH:D052776 Female Urogenital Diseases Tamoxifen 2.6116709447
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 3.6314745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 3.2919069698
MESH:D005393 Fish Diseases Niclosamide 8.3112113305
MESH:D005393 Fish Diseases Quinine 8.3112113305
MESH:D018316 Gliosarcoma Cyclophosphamide 4.6211389073
MESH:D006086 Graft vs Host Disease Cyclophosphamide 4.1615172196 11014644 16376943
MESH:D006333 Heart Failure Plant Extracts 5.9218097624
MESH:D006333 Heart Failure Propranolol 5.9220082655
MESH:D006402 Hematologic Diseases Benzene 3.8216183116
MESH:D006467 Hemophilia A Cyclophosphamide 4.4111918545
MESH:D006504 Hepatic Veno-Occlusive Disease Cyclophosphamide 4.6214986274
MESH:D006505 Hepatitis Caffeine 7.3011394713
MESH:D006505 Hepatitis Diazinon 7.3016487989
MESH:D006529 Hepatomegaly Amiodarone 9.8615265979
MESH:D006529 Hepatomegaly perfluorooctanoic acid 9.863609246
MESH:D006529 Hepatomegaly Propranolol 9.8616371745
MESH:D006556 Heroin Dependence Buprenorphine 6.1812756210
MESH:D006561 Herpes Simplex Chlorpromazine 7.581682908
MESH:D006561 Herpes Simplex Plant Extracts 7.5810715843
MESH:D015658 HIV Infections Plant Extracts 5.5612878215
MESH:D015658 HIV Infections Ritonavir 5.5611363243 11141242 17378895 15388451
MESH:D006689 Hodgkin Disease Cyclophosphamide 3.0517606976 16135485
MESH:D019584 Hot Flashes Fluoxetine 17.2314716179
MESH:D019584 Hot Flashes Paroxetine 17.2314716179
MESH:D019584 Hot Flashes Plant Extracts 17.2314716179 16566672 17454163
MESH:D019584 Hot Flashes venlafaxine 17.2314716179
MESH:D006816 Huntington Disease Sertraline 5.1418403212
MESH:D006930 Hyperalgesia perfluorooctanoic acid 5.8612083418
MESH:D006930 Hyperalgesia rosiglitazone 5.8612083418
MESH:D006934 Hypercalcemia bortezomib 4.6318089816
MESH:D006937 Hypercholesterolemia Amiodarone 3.078137927 9751232
MESH:D006943 Hyperglycemia Risperidone 4.3718278980
MESH:D020138 Hyperhomocysteinemia Plant Extracts 3.6916484555
MESH:D006948 Hyperkinesis Amphetamine 8.831977408 14960337
MESH:D006948 Hyperkinesis Clozapine 8.8316046005
MESH:D006949 Hyperlipidemias Plant Extracts 3.6515975614 15268973
MESH:D017495 Hyperpigmentation 1-phenylazo-2-naphthol 6.341402006
MESH:D006973 Hypertension Benzene 2.6817940673
MESH:D006976 Hypertension, Pulmonary gefitinib 4.0118424623
MESH:D017380 Hypertrophy, Right Ventricular gefitinib 5.3418424623
MESH:D007021 Hypospadias Loratadine 5.2316407038
MESH:D007022 Hypotension Propranolol 4.366740701
MESH:D007037 Hypothyroidism Amiodarone 3.6418020914 17991464
MESH:D007154 Immune System Diseases Cyclophosphamide 4.4216076520
MESH:D007248 Infertility, Male Cyclophosphamide 7.8416517039 7193160
MESH:D007248 Infertility, Male Diazinon 7.8412948887 16466525
MESH:D007248 Infertility, Male Parathion 7.8416029889
MESH:D007249 Inflammation Amitriptyline 15.6912798668
MESH:D007249 Inflammation Fluoxetine 15.6912798668
MESH:D007249 Inflammation Imipramine 15.6912798668
MESH:D007249 Inflammation perfluorooctanoic acid 15.6912083418
MESH:D007249 Inflammation Plant Extracts 15.6919332304 15997105 16366677 12787963
MESH:D007249 Inflammation rosiglitazone 15.6912083418
MESH:D007249 Inflammation Tamoxifen 15.6919457130
MESH:D007333 Insulin Resistance rosiglitazone 3.1616306350
MESH:D007414 Intestinal Neoplasms Plant Extracts 3.8212351151 12584176 12628509
MESH:D007680 Kidney Neoplasms gefitinib 5.4818625569
MESH:D007680 Kidney Neoplasms Tamoxifen 5.4818625569
MESH:D007896 Leishmaniasis Pentamidine 4.6215340016
MESH:D016773 Leishmaniasis, Cutaneous Ketoconazole 6.948889330 2166429 19744259 1311351
MESH:D016773 Leishmaniasis, Cutaneous Pentamidine 6.9410617787 8889330 12453009 11806628
MESH:D007897 Leishmaniasis, Mucocutaneous Pentamidine 5.1810881086
MESH:D007898 Leishmaniasis, Visceral Ketoconazole 6.5511332679
MESH:D007898 Leishmaniasis, Visceral Pentamidine 6.5512803856 1659303 7498017 7715298 10467834 16131481
MESH:D007938 Leukemia Benzene 5.0017119257 14694614 15935818 18335105
MESH:D007938 Leukemia Cyclophosphamide 5.0010602166
MESH:D015451 Leukemia, Lymphocytic, Chronic, B-Cell Cyclophosphamide 3.0217008537 18172266 17802794 17296974 18587576 17658394
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell bortezomib 8.0418089816
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell Ritonavir 8.0416174765
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive Cyclophosphamide 3.3810373061
MESH:D007951 Leukemia, Myeloid Benzene 3.5117506065
MESH:D015470 Leukemia, Myeloid, Acute Benzene 3.7719478238
MESH:D015470 Leukemia, Myeloid, Acute bortezomib 3.7720471514
MESH:D007970 Leukopenia Cyclophosphamide 4.0711830472 10052129
MESH:D007984 Leydig Cell Tumor perfluorooctanoic acid 4.338812269
MESH:D008064 Lipidoses Amiodarone 51.8315342952 17567588
MESH:D008064 Lipidoses Amitriptyline 51.8317567588 15342952
MESH:D008064 Lipidoses Chlorpromazine 51.8315342952 17567588
MESH:D008064 Lipidoses Citalopram 51.8317567588
MESH:D008064 Lipidoses Clozapine 51.8317567588
MESH:D008064 Lipidoses Fluoxetine 51.8317567588 15342952
MESH:D008064 Lipidoses Imipramine 51.8317567588 15342952
MESH:D008064 Lipidoses Ketoconazole 51.8317567588
MESH:D008064 Lipidoses Loratadine 51.8317567588
MESH:D008064 Lipidoses Sertraline 51.8317567588
MESH:D008064 Lipidoses Tamoxifen 51.8317567588 15342952
MESH:D008064 Lipidoses Thioridazine 51.8317567588 15342952
MESH:D008103 Liver Cirrhosis Plant Extracts 3.1717157831
MESH:D008106 Liver Cirrhosis, Experimental Plant Extracts 2.8215479170
MESH:D008106 Liver Cirrhosis, Experimental rosiglitazone 2.8215980055 17347453
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 2.8218564211
MESH:D008107 Liver Diseases Chlorpromazine 5.0014986274
MESH:D008107 Liver Diseases Chlorpyrifos 5.0015991261
MESH:D008107 Liver Diseases Plant Extracts 5.0017034775
MESH:D017114 Liver Failure, Acute venlafaxine 4.6019857765
MESH:D008113 Liver Neoplasms 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone 9.5215890375
MESH:D008113 Liver Neoplasms 9-(4'-aminophenyl)-9H-pyrido(3,4-b)indole 9.5212970073
MESH:D008113 Liver Neoplasms perfluorooctanoic acid 9.5218709148 14757943
MESH:D008113 Liver Neoplasms Plant Extracts 9.5219168119
MESH:D008113 Liver Neoplasms Tamoxifen 9.5216684651
MESH:D008114 Liver Neoplasms, Experimental 1-phenylazo-2-naphthol 4.942563599
MESH:D008114 Liver Neoplasms, Experimental Benzene 4.9412562636
MESH:D008133 Long QT Syndrome Amiodarone 13.6415350150 11989578 17391786
MESH:D008133 Long QT Syndrome Metoprolol 13.6419353679
MESH:D008133 Long QT Syndrome Quinidine 13.6415350150 11989578
MESH:D008133 Long QT Syndrome Thioridazine 13.6420210726
MESH:D008171 Lung Diseases Amiodarone 2.7212587719
MESH:D017563 Lung Diseases, Interstitial Amiodarone 8.4518516814
MESH:D017563 Lung Diseases, Interstitial Benzene 8.4514698565
MESH:D055370 Lung Injury 4-ipomeanol 5.252384072
MESH:D008175 Lung Neoplasms 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone 3.5518508827 9255578 15893417 14755239 19931552 15172992 12438228 18813816 16401635 16061637 17139156
MESH:D008175 Lung Neoplasms Benzene 3.5512562636
MESH:D008175 Lung Neoplasms Plant Extracts 3.5520869020
MESH:D008175 Lung Neoplasms Tamoxifen 3.5518625569
MESH:D008178 Lupus Erythematosus, Cutaneous Rifampin 5.2311422169
MESH:D008180 Lupus Erythematosus, Systemic Rifampin 3.6411422169
MESH:D008223 Lymphoma Benzene 8.8617584886 17119257
MESH:D008223 Lymphoma bortezomib 8.8616098063
MESH:D008223 Lymphoma Cyclophosphamide 8.8612854902
MESH:D016393 Lymphoma, B-Cell bortezomib 8.0716675587
MESH:D016393 Lymphoma, B-Cell Cyclophosphamide 8.0716675587
MESH:D008228 Lymphoma, Non-Hodgkin Cyclophosphamide 3.4111911406
MESH:D016778 Malaria, Falciparum Thioridazine 4.9016882315
MESH:D015674 Mammary Neoplasms, Animal Benzene 7.1212562636
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 7.1219428831
MESH:D008325 Mammary Neoplasms, Experimental Benzene 9.1411921183
MESH:D008325 Mammary Neoplasms, Experimental gefitinib 9.1418375820
MESH:D008325 Mammary Neoplasms, Experimental rosiglitazone 9.1416827153
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 9.1411731420 19196722 14580682 19196723 16827153
MESH:D020149 Manganese Poisoning Tamoxifen 3.6319453300
MESH:D008527 Medulloblastoma bortezomib 3.7819213072
MESH:D008545 Melanoma Tamoxifen 1.7419393235 12393984
MESH:D018328 Melanoma, Amelanotic Tamoxifen 3.2915990972
MESH:D008546 Melanoma, Experimental Cyclophosphamide 3.9316388313
MESH:D001523 Mental Disorders Amitriptyline 56.1616856516
MESH:D001523 Mental Disorders Chlorpromazine 56.1616856516
MESH:D001523 Mental Disorders Citalopram 56.1616856516
MESH:D001523 Mental Disorders Clozapine 56.1616856516
MESH:D001523 Mental Disorders Desipramine 56.1616856516
MESH:D001523 Mental Disorders Fluoxetine 56.1616856516
MESH:D001523 Mental Disorders Haloperidol 56.1616856516
MESH:D001523 Mental Disorders Imipramine 56.1616856516
MESH:D001523 Mental Disorders Nortriptyline 56.1616856516
MESH:D001523 Mental Disorders Paroxetine 56.1616856516
MESH:D001523 Mental Disorders Risperidone 56.1616856516 16596465
MESH:D001523 Mental Disorders Sertraline 56.1616856516
MESH:D001523 Mental Disorders Thioridazine 56.1616856516
MESH:D001523 Mental Disorders venlafaxine 56.1616856516
MESH:D008607 Mental Retardation Risperidone 3.7218349709
MESH:D024821 Metabolic Syndrome X Clozapine 11.7719142101
MESH:D024821 Metabolic Syndrome X Risperidone 11.7719142101
MESH:D024821 Metabolic Syndrome X rosiglitazone 11.7717261469
MESH:D008708 Methemoglobinemia Chloroquine 7.773537620
MESH:D008708 Methemoglobinemia Primaquine 7.773537620
MESH:D008881 Migraine Disorders Amitriptyline 6.4118803445
MESH:D008881 Migraine Disorders venlafaxine 6.4118803445
MESH:D019964 Mood Disorders Risperidone 4.9517019624
MESH:D009101 Multiple Myeloma Benzene 5.7217119195
MESH:D009101 Multiple Myeloma bortezomib 5.7219372569 19112201 19112817
MESH:D009164 Mycobacterium Infections Rifampin 8.7118474467
MESH:D009164 Mycobacterium Infections Ritonavir 8.7121442799
MESH:D009175 Mycoplasma Infections Chlorpromazine 5.0910773494
MESH:D009181 Mycoses Amiodarone 3.9912754197 17974566
MESH:D009203 Myocardial Infarction Metoprolol 4.2818072171
MESH:D009207 Myoclonus Fluoxetine 4.988041377
MESH:D009224 Myotonia Congenita Quinine 5.341896199
MESH:D009362 Neoplasm Metastasis Tamoxifen 2.1119393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.1319410462
MESH:D009369 Neoplasms Cyclophosphamide 2.6818854779
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 3.0919200415 19189210 19196722
MESH:D009436 Neural Tube Defects Benzene 3.0415643154
MESH:D019954 Neurobehavioral Manifestations Plant Extracts 4.3017168769
MESH:D009447 Neuroblastoma Cyclophosphamide 3.098761367 15176712 16115947
MESH:D019636 Neurodegenerative Diseases 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine 7.0712349958
MESH:D019636 Neurodegenerative Diseases Amphetamine 7.0715183010
MESH:D017599 Neuroectodermal Tumors Cyclophosphamide 4.0012837982 8761367
MESH:D020258 Neurotoxicity Syndromes 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine 6.7416725203
MESH:D020258 Neurotoxicity Syndromes Chlorpyrifos 6.7415081274
MESH:D009503 Neutropenia Cyclophosphamide 7.288291058
MESH:D009503 Neutropenia Ritonavir 7.2817378895
MESH:D052556 Niemann-Pick Disease, Type C perfluorooctanoic acid 4.079802331
MESH:D053206 Nocturnal Enuresis Risperidone 5.4217822346
MESH:D009765 Obesity Clozapine 4.0918515891 19142110
MESH:D009765 Obesity Plant Extracts 4.0919056576 20132043
MESH:D009771 Obsessive-Compulsive Disorder Fluoxetine 13.8720418887
MESH:D009771 Obsessive-Compulsive Disorder Paroxetine 13.8717503984
MESH:D009771 Obsessive-Compulsive Disorder venlafaxine 13.8717503984
MESH:D009784 Occupational Diseases marker/mechanism 16737584
MESH:D009784 Occupational Diseases Benzene 3.3916737584 17178637 15913788 17119257 15727169 15576619 15935809 17479406 15612468
MESH:D009845 Oligospermia Cyclophosphamide 3.8216517039
MESH:D010051 Ovarian Neoplasms Benzene 2.6212562636
MESH:D010146 Pain Amitriptyline 16.8912798668
MESH:D010146 Pain Cyclophosphamide 16.8918093676 12161096
MESH:D010146 Pain Fluoxetine 16.8912798668
MESH:D010146 Pain Imipramine 16.8912798668
MESH:D010146 Pain Morphine 16.896776300 16273134 18699797 15275824 20225289 15215642
MESH:D010146 Pain Tramadol 16.8918204346
MESH:D010190 Pancreatic Neoplasms 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone 4.4612384795
MESH:D010190 Pancreatic Neoplasms Cyclophosphamide 4.4611332152
MESH:D010195 Pancreatitis Cimetidine 4.4710484002
MESH:D010212 Papilloma Plant Extracts 3.6316517061 15173996
MESH:D010300 Parkinson Disease marker/mechanism
MESH:D010300 Parkinson Disease 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine 5.2415451049 11181820 16140633
MESH:D010300 Parkinson Disease Desipramine 5.2410965161
MESH:D020734 Parkinsonian Disorders 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine 4.7712349958
MESH:D020774 Pick Disease of the Brain Fluoxetine 5.128041377
MESH:D011020 Pneumonia, Pneumocystis Pentamidine 5.8015340016
MESH:D011041 Poisoning Diazinon 3.5417603234
MESH:D011230 Precancerous Conditions 1-phenylazo-2-naphthol 4.922563599
MESH:D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma Cyclophosphamide 3.2221297632
MESH:D011297 Prenatal Exposure Delayed Effects perfluorooctanoic acid 3.5117132714
MESH:D011471 Prostatic Neoplasms Cyclophosphamide 2.1517136230
MESH:D011471 Prostatic Neoplasms gefitinib 2.1517914592 15651060 16685379
MESH:D011471 Prostatic Neoplasms Ketoconazole 2.1517404083
MESH:D011471 Prostatic Neoplasms Plant Extracts 2.1517804756 14666653
MESH:D011471 Prostatic Neoplasms Tamoxifen 2.1515067354
MESH:D011595 Psychomotor Agitation Haloperidol 4.0811575062
MESH:D011618 Psychotic Disorders Clozapine 10.8315331141
MESH:D011618 Psychotic Disorders Haloperidol 10.8311575062
MESH:D011618 Psychotic Disorders Thioridazine 10.8316882315
MESH:D011658 Pulmonary Fibrosis Amiodarone 6.8711597910 12490602 12832656
MESH:D011658 Pulmonary Fibrosis Cyclophosphamide 6.8716636934
MESH:D011658 Pulmonary Fibrosis gefitinib 6.8718424623
MESH:D015427 Reperfusion Injury Morphine 3.6119211983
MESH:D012135 Respiratory Sounds Chlorpyrifos 7.5117119214 11874814 16611668
MESH:D012135 Respiratory Sounds Parathion 7.5111874814 17119214
MESH:D012140 Respiratory Tract Diseases Chlorpyrifos 8.2616611668 17119214
MESH:D012140 Respiratory Tract Diseases Parathion 8.2617119214
MESH:D012559 Schizophrenia Clozapine 4.5520107430 20452607 16141801 19369910 18855531 11151749 20580759 17123785 20521326 20168265 17726453 18806925 11763009 20521320 17667964
MESH:D012559 Schizophrenia Haloperidol 4.5520107430 19369910 1830565 18513383
MESH:D012559 Schizophrenia Risperidone 4.5518278980 19154706 20107430
MESH:D012595 Scleroderma, Systemic Cyclophosphamide 3.9816636934
MESH:D020230 Serotonin Syndrome Fluoxetine 4.998704074
MESH:D012729 Sex Chromosome Aberrations Chlorpyrifos 5.176418539
OMIM:609620 SHORT QT SYNDROME 1 Amiodarone 4.1918724381
MESH:D012878 Skin Neoplasms Plant Extracts 2.9915173996 16517061
MESH:D012891 Sleep Apnea Syndromes Codeine 7.0017564651
MESH:D012892 Sleep Deprivation Imipramine 5.3019798453
MESH:D012893 Sleep Disorders Caffeine 8.5319395429
MESH:D012893 Sleep Disorders Risperidone 8.5318278980
MESH:D007319 Sleep Initiation and Maintenance Disorders Amitriptyline 7.8115341891
MESH:D007319 Sleep Initiation and Maintenance Disorders Caffeine 7.8117225163
MESH:D013088 Spermatocele Tamoxifen 3.3816709447
OMIM:102530 SPERMATOGENIC FAILURE 6 Cyclophosphamide 4.6216517039
MESH:D013119 Spinal Cord Injuries Tamoxifen 3.1519457130
MESH:D013158 Splenic Diseases aniline 5.5015694462
MESH:D013167 Spondylitis, Ankylosing marker/mechanism
MESH:D019956 Stereotypic Movement Disorder Amphetamine 5.511977408
MESH:D013274 Stomach Neoplasms Benzene 2.4412562636
MESH:D013276 Stomach Ulcer Amiodarone 4.9918087811
MESH:D013276 Stomach Ulcer Plant Extracts 4.9918193104 12787963 18237397 15255614 17135157
MESH:D015173 Supratentorial Neoplasms Cyclophosphamide 4.1612837982
MESH:D013610 Tachycardia Amiodarone 3.4311238279
MESH:D017180 Tachycardia, Ventricular Amiodarone 17.7919225199
MESH:D017180 Tachycardia, Ventricular Haloperidol 17.7920210726
MESH:D017180 Tachycardia, Ventricular Risperidone 17.7920210726
MESH:D017180 Tachycardia, Ventricular Thioridazine 17.7920210726
MESH:D013705 Temporomandibular Joint Disorders Plant Extracts 4.5717997062
MESH:D013927 Thrombosis Ticlopidine 5.2119432301
MESH:D013953 Thymus Neoplasms Benzene 4.0610850423
MESH:D013959 Thyroid Diseases Amiodarone 3.8519731979
MESH:D013964 Thyroid Neoplasms gefitinib 3.7816940797
MESH:D013971 Thyrotoxicosis Amiodarone 3.9818020914 19584973
MESH:D016171 Torsades de Pointes Amiodarone 8.0617467628 11989578
MESH:D016171 Torsades de Pointes Metoprolol 8.0619353679
MESH:D005879 Tourette Syndrome Risperidone 5.0619154706
MESH:D014352 Trypanosomiasis Pentamidine 5.6015340016
MESH:D014353 Trypanosomiasis, African Melarsoprol 6.8811551633 11348535
MESH:D014376 Tuberculosis Rifampin 4.1415236969 18397238
MESH:D001749 Urinary Bladder Neoplasms Cyclophosphamide 3.8514692829
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 3.8517572228 16712894 8653321
MESH:D014570 Urologic Diseases Diazinon 4.3716487989
MESH:D014581 Urticaria Loratadine 4.552568013
MESH:D014594 Uterine Neoplasms Benzene 3.4912562636
MESH:D020301 Vasospasm, Intracranial Nicardipine 5.3519057314
MESH:D018487 Ventricular Dysfunction, Left Plant Extracts 3.8818097624
MESH:D020257 Ventricular Remodeling Plant Extracts 4.4218097624
MESH:D015430 Weight Gain Clozapine 7.7820107430 16141801 20564506 17502770 20521320 16402076
MESH:D015430 Weight Gain Risperidone 7.7820564506 16379507
MESH:D015431 Weight Loss Clozapine 4.1817933447
MESH:D014947 Wounds and Injuries Plant Extracts 3.5020213670 19894650
Pathway ID Pathway Name
KEGG:00982 Drug metabolism - cytochrome P450
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA128
    • Releated gene ID Related gene Name
    PA128CYP2D6
    Releated disease ID Related disease Name
    PA443319Alzheimer Disease
    PA443853Dementia
    PA446098Dementia, Vascular
    PA447127Lewy Body Disease
    PA446858Neurodegenerative Diseases
    PA443530Body Weight Changes
    PA165108622Drug interaction with drug
    PA165374639suicide
    PA445425Prostatic Neoplasms
    PA447196Anxiety Disorders
    PA447207Depressive Disorder
    PA447215Psychotic Disorders
    PA445618Sclerosis
    PA447268tardive dyskinesia
    PA446861Hepatitis, Autoimmune
    PA443899Diarrhea
    PA447321Depressive Disorder, Major
    PA445048Nausea
    PA446051Vomiting
    PA445254Parkinson Disease
    PA443842Death
    PA447062Parkinsonian Disorders
    PA446863Hepatitis C, Chronic
    PA444516Hypercholesterolemia
    PA444528Hyperlipidemias
    PA444997Muscular Diseases
    PA157379134Myalgia unspecified
    PA445028Myositis
    PA443829Cystic Fibrosis
    PA445062Neoplasms
    PA151958338Neonatal death
    PA444552Hypertension
    PA443560Breast Neoplasms
    PA446108Colorectal Neoplasms
    PA444750Leukemia
    PA445204Ovarian Neoplasms
    PA443937Drug Toxicity
    PA443548Bradycardia
    PA443485Basal Cell Nevus Syndrome
    PA445549Rhabdomyolysis
    PA447250codeine dependence
    PA445208Pain
    PA447278Depression
    PA444818Lung Neoplasms
    PA447216Schizophrenia
    PA443890Diabetes Mellitus, Type 2
    Releated drug ID Related drug Name
    PA164712423Anticholinesterases
    PA163522473tipranavir
    PA449319digoxin
    PA449412doxorubicin
    PA128406956fluorouracil
    PA449383docetaxel
    PA451644thalidomide
    PA164712445Antihypertensives
    PA451128promethazine
    PA165291499GS-9350
    PA10816ezetimibe
    PA448408amphetamine
    PA448817carvedilol
    PA449160cyclobenzaprine
    PA448960chlorpheniramine
    PA449349diphenhydramine
    PA448591benztropine
    PA451583tamsulosin
    PA450475metoclopramide
    PA10804imatinib
    PA450741oxycodone
    PA10026aripiprazole
    PA449900hydrocodone
    PA164712535Beta Blocking Agents
    PA449394donepezil
    PA164712507Anxiolytics
    PA162372877Nilotinib
    PA164754754cevimeline
    PA451168protriptyline
    PA451614terbinafine
    PA164746757tolterodine
    PA448404amodiaquine
    PA452609aflatoxin b1
    PA450262loperamide
    PA452610sparteine
    PA452618opioids
    PA449334diltiazem
    PA451999interferons
    PA451241ribavirin
    PA4519911-methyloxy-4-sulfone-benzene
    PA451866venlafaxine
    PA451145propranolol
    PA448710caffeine
    PA450401methadone
    PA450496midazolam
    PA448515azathioprine
    PA450379mercaptopurine
    PA452229antidepressants
    PA450373mephenytoin
    PA151958426nebivolol
    PA449165cyclophosphamide
    PA450761paclitaxel
    PA452620tegafur
    PA449676fluphenazine
    PA451906warfarin
    PA451946yohimbine
    PA451581tamoxifen
    PA1318870083,4-methylenedioxymethamphetamine
    PA451744trazodone
    PA134687941desmethylcitalopram
    PA134687942levomepromazine
    PA450322maprotiline
    PA134687937mianserin
    PA450657nortriptyline
    PA450688olanzapine
    PA451741tranylcypromine
    PA134688071atomoxetine
    PA1519586374-methylthioamphetamine
    PA448871celecoxib
    PA448687bupropion
    PA131301952gefitinib
    PA452627flavopiridol
    PA448073ethanol
    PA450588naltrexone
    PA452233antipsychotics
    PA448333alprazolam
    PA449167cyclosporine
    PA450266loratadine
    PA451647theophylline
    PA449409doxepin
    PA450522mirtazapine
    PA448015acetaminophen
    PA451142propoxyphene
    PA10066duloxetine
    PA10074escitalopram
    PA450480metoprolol
    PA451333sertraline
    PA451363simvastatin
    PA450550morphine
    PA452610sparteine
    PA449088codeine
    PA452616debrisoquine
    PA449273dextromethorphan
    PA449233desipramine
    PA130150436perhexiline
    PA449015citalopram
    PA449690fluvoxamine
    PA451668thiotepa
    PA451131propafenone
    PA451690timolol
    PA448385amitriptyline
    PA449048clomipramine
    PA449969imipramine
    PA449841haloperidol
    PA451257risperidone
    PA451666thioridazine
    PA449646flecainide
    PA449673fluoxetine
    PA451735tramadol
    PA449001cimetidine
    PA449072cocaine
    PA450801paroxetine
    PA451260ritonavir
    PA450704omeprazole
    PA450488mexiletine
    PA449061clozapine
    PA450882perphenazine
    PA452629zuclopenthixol
    PA452604xenobiotics
    PA449293diclofenac
    PA449493erythromycin
    PA449688fluvastatin
    PA449782glibenclamide
    PA450132itraconazole
    PA450146ketoconazole
    PA450268losartan
    PA451250rifampin
    PA451718tolbutamide
    PA448897cerivastatin
    PA448500atorvastatin
    PA451089pravastatin
    PA448388amlodipine
    PA448905cetirizine
    PA448948chloroquine
    PA448964chlorpromazine
    PA164776671cinacalcet
    PA164776997clemastine
    PA449223delavirdine
    PA164746377diphenylpyraline
    PA449441efavirenz
    PA449591felodipine
    PA449720gabapentin
    PA449839halofantrine
    PA449943hydroxyzine
    PA449977indinavir
    PA450606nelfinavir
    PA450616nevirapine
    PA450620nicardipine
    PA450631nifedipine
    PA450965pimozide
    PA451201quetiapine
    PA451224ranitidine
    PA144614921reboxetine
    PA451305saquinavir
    PA451669thiothixene
    PA451686ticlopidine
    PA164764429tripelennamine
    PA451868verapamil
    PA451974ziprasidone
    PA450970pioglitazone
    PA449726galantamine
    PA451209quinidine
    PA448383amiodarone
    PA451627testosterone
    PA451103primaquine
    PA164769056tiotropium
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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