AutismKB 2.0

Annotation Detail for ADRBK2


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Basic Information Top
Gene Symbol:ADRBK2 ( BARK2,GRK3 )
Gene Full Name: adrenergic, beta, receptor kinase 2
Band: 22q11|22q12.1
Quick LinksEntrez ID:157; OMIM: 109636; Uniprot ID:ARBK2_HUMAN; ENSEMBL ID: ENSG00000100077; HGNC ID:
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04144Endocytosis
hsa04740Olfactory transduction
hsa04062Chemokine signaling pathway
No data
No data
Pathway IDPathway Name
P00026Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
P00049Parkinson disease
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
2045Bipolar disorder
No data
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of ADRBK2 mRNAaffects expression 17562736
D000643 Ammonium Chloride Ammonium Chloride affects the expression of ADRBK2 mRNAaffects expression 16483693
D002713 Chlorine Chlorine results in increased expression of ADRBK2 mRNAincreases expression 18636392
D002713 Chlorine [Ozone co-treated with Chlorine] results in increased expression of ADRBK2 mRNAaffects cotreatment|increases expression 18636392
D004390 Chlorpyrifos Chlorpyrifos affects the expression of ADRBK2 mRNAaffects expression 18812211
D004390 Chlorpyrifos Chlorpyrifos results in increased expression of ADRBK2 mRNAincreases expression 17452286
D003976 Diazinon Diazinon results in increased expression of ADRBK2 mRNAincreases expression 17452286
D006830 Hydralazine [Hydralazine co-treated with Valproic Acid] results in decreased expression of ADRBK2 mRNAaffects cotreatment|decreases expression 17183730
D010126 Ozone [Ozone co-treated with Chlorine] results in increased expression of ADRBK2 mRNAaffects cotreatment|increases expression 18636392
D014028 Tobacco Smoke Pollution Tobacco Smoke Pollution results in decreased expression of ADRBK2 mRNAdecreases expression 18087596
D014635 Valproic Acid [Hydralazine co-treated with Valproic Acid] results in decreased expression of ADRBK2 mRNAaffects cotreatment|decreases expression 17183730
D014810 Vitamin E Vitamin E results in decreased expression of ADRBK2 mRNAdecreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 3.728875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 4.1019490988
MESH:D000138 Acidosis Ammonium Chloride 3.8018287403
MESH:D055371 Acute Lung Injury Chlorine 4.5120601635
MESH:D002282 Adenocarcinoma, Bronchiolo-Alveolar Tobacco Smoke Pollution 5.7915814487
MESH:D000382 Agricultural Workers' Diseases Chlorpyrifos 9.9816611668 11874814 17119214
MESH:D000382 Agricultural Workers' Diseases Diazinon 9.9816487989
MESH:D000544 Alzheimer Disease Ozone 2.4715513908
MESH:D000550 Amblyopia Valproic Acid 5.5017688650
MESH:D000799 Angioedema Acetaminophen 4.1110982225
MESH:D001008 Anxiety Disorders Valproic Acid 3.7117497229
MESH:D001172 Arthritis, Rheumatoid Ozone 5.1315570426
MESH:D001172 Arthritis, Rheumatoid Tobacco Smoke Pollution 5.1319898480
MESH:D001249 Asthma Ozone 2.6816373670 17854713
MESH:D001321 Autistic Disorder Acetaminophen 1.8618445737
MESH:D001321 Autistic Disorder Valproic Acid 1.8615238991 17157402 19232924 17507914 16609825 18396377 18177632 17688650 18775368 18940202 19460635 18316065 18985861 20603192 18558336
MESH:D001714 Bipolar Disorder marker/mechanism 12808434
MESH:D001714 Bipolar Disorder Valproic Acid 3.1517594078 20046352
MESH:D001848 Bone Diseases, Developmental Valproic Acid 3.518888407
MESH:D016535 Bronchial Hyperreactivity Ozone 3.8115516495 18417511 18315731 17626835 19059883 16777450 14754758
MESH:D002100 Cachexia Ozone 4.9816183385
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 4.1516050911
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 1.393084413
MESH:D002289 Carcinoma, Non-Small-Cell Lung Tobacco Smoke Pollution 3.4711212258
MESH:D002294 Carcinoma, Squamous Cell Tobacco Smoke Pollution 3.2511212258
MESH:D002386 Cataract Acetaminophen 2.6710977129
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.7620734317
MESH:D019465 Craniofacial Abnormalities Valproic Acid 2.768888407 17688650 16575769
MESH:D019465 Craniofacial Abnormalities Vitamin E 2.7619769572
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 3.9415619225 19739265 12594235 11529661 16081117 11461765 19923254 11743745 19085960 18713872 16485898 12153990 16177239 11739529 12392966 14550746 2444490 12540782 10774834 19416960 19164858 10663392 17562736 14725611 19420014 16227642 19370779 17522070 16393943 11421492 15968718 12705907 16109766 17906064 12958197 11287661 10915739 14986274 18071297 16781746 11834606
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 3.9419641884 1733752
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.3619426721
MESH:D004417 Dyspnea Chlorine 11.5820016425
MESH:D004417 Dyspnea Diazinon 11.5816487989
MESH:D004421 Dystonia Valproic Acid 4.231851702
MESH:C538011 Eales disease Vitamin E 4.979068938
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 4.373659116 17275665
MESH:D004828 Epilepsies, Partial Valproic Acid 4.183922381 16628512
MESH:D004827 Epilepsy Valproic Acid 3.0120417680 18234410
MESH:D004832 Epilepsy, Absence Valproic Acid 3.747562514 6426943 6254150
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 4.517750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 4.303659116
MESH:D005234 Fatty Liver Valproic Acid 3.4719224547 14986274
MESH:D005315 Fetal Diseases Valproic Acid 5.1516575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 4.338888407 18558336
MESH:D005739 Gas Poisoning Chlorine 5.2720016425
MESH:D005756 Gastritis Acetaminophen 3.9416983495
MESH:D006330 Heart Defects, Congenital Vitamin E 3.0716080930
MESH:D006505 Hepatitis Diazinon 4.7716487989
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.7516490937 16863852
MESH:D019584 Hot Flashes Vitamin E 4.2414716179
MESH:D006849 Hydrocephalus Valproic Acid 5.1017688650
MESH:D006930 Hyperalgesia Acetaminophen 2.8416870215
MESH:D046110 Hypertension, Pregnancy-Induced Hydralazine 4.8416612254
MESH:D007248 Infertility, Male Diazinon 3.9312948887 16466525
MESH:D007249 Inflammation Tobacco Smoke Pollution 3.4218590791
MESH:D007251 Influenza, Human Vitamin E 4.4816624496
MESH:D007674 Kidney Diseases Acetaminophen 6.2715629191 12587719
MESH:D007674 Kidney Diseases Vitamin E 6.2712488133
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 2.1716294345 17596541
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 1.9016169303
MESH:D008107 Liver Diseases Acetaminophen 4.3919784758 12587719 19460945 16611625 12969438 11587558 16610002 19014921
MESH:D008107 Liver Diseases Chlorpyrifos 4.3915991261
MESH:D017114 Liver Failure, Acute Acetaminophen 3.4016871587 17185352
MESH:D008171 Lung Diseases Ozone 7.898266340 19066396
MESH:D008171 Lung Diseases Vitamin E 7.8916863852
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 4.5317228818
MESH:D055370 Lung Injury Ozone 4.0620417186
MESH:D008175 Lung Neoplasms Ozone 3.738597069 7614698
MESH:D008175 Lung Neoplasms Tobacco Smoke Pollution 3.7312111688 11091918 3440675 16288123
MESH:D008175 Lung Neoplasms Vitamin E 3.7311062179
MESH:D008546 Melanoma, Experimental Acetaminophen 3.7819513568
MESH:D008679 Metaplasia Ozone 5.3710496685
MESH:D008881 Migraine Disorders Valproic Acid 3.3118803445 18765137
MESH:D009062 Mouth Neoplasms Tobacco Smoke Pollution 4.4815006635
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 4.208888407
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 3.2417596541
MESH:D009436 Neural Tube Defects Valproic Acid 3.238888407 16359493
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.0118514411
MESH:D020258 Neurotoxicity Syndromes Chlorpyrifos 4.2815081274
MESH:D010146 Pain Acetaminophen 2.5316870215
MESH:D010538 Peritonitis Ozone 4.3516369182
MESH:D011014 Pneumonia Ozone 4.6318007984 18381685 18929643
MESH:D011041 Poisoning Diazinon 4.5317603234
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 4.0720603192
MESH:D011471 Prostatic Neoplasms Vitamin E 3.2815084515
MESH:D019310 Pseudolymphoma Valproic Acid 4.8111422049 12752131
MESH:D012120 Respiration Disorders Chlorine 5.4818579056
MESH:D012135 Respiratory Sounds Chlorpyrifos 10.8811874814 16611668 17119214
MESH:D012135 Respiratory Sounds Tobacco Smoke Pollution 10.8818410779
MESH:D012140 Respiratory Tract Diseases Chlorpyrifos 5.1617119214 16611668
MESH:D012208 Rhabdomyosarcoma Valproic Acid 4.3619155313
MESH:D012559 Schizophrenia Valproic Acid 2.0919110320 15737665
MESH:D012640 Seizures Valproic Acid 2.8511738929 17978042 15475178 16876388 3137016 14763951 11044598 1511512
MESH:D012729 Sex Chromosome Aberrations Chlorpyrifos 6.356418539
MESH:D012871 Skin Diseases Vitamin E 2.4818709164
MESH:D012878 Skin Neoplasms Tobacco Smoke Pollution 3.6018590791
MESH:D016135 Spinal Dysraphism Valproic Acid 3.9119490988
MESH:D013226 Status Epilepticus Valproic Acid 4.8112833885
MESH:D020521 Stroke Vitamin E 3.6616517955
MESH:D014178 Translocation, Genetic Valproic Acid 5.5017262798
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.763119515
MESH:D001749 Urinary Bladder Neoplasms Tobacco Smoke Pollution 3.3912846360
MESH:D014564 Urogenital Abnormalities Valproic Acid 4.868888407
MESH:D014570 Urologic Diseases Diazinon 5.5416487989
MESH:D014581 Urticaria Acetaminophen 3.1610982225
Pathway ID Pathway Name
KEGG:04062 Chemokine signaling pathway
KEGG:04144 Endocytosis
KEGG:04724 Glutamatergic synapse
KEGG:04740 Olfactory transduction
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA41
    • No data
    Releated disease ID Related disease Name
    PA444370Heart Failure
    PA444552Hypertension
    Releated drug ID Related drug Name
    PA448478l-arginine
    PA450635nitric oxide
    PA164712535Beta Blocking Agents
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB00171 - Adenosine triphosphate Dietary supplement;Micronutrient
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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