AutismKB 2.0

Annotation Detail for CDCA2


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Basic Information Top
Gene Symbol:CDCA2 ( FLJ25804,MGC129906,MGC129907,Repo-Man )
Gene Full Name: cell division cycle associated 2
Band: 8p21.2
Quick LinksEntrez ID:157313; OMIM: NA; Uniprot ID:CDCA2_HUMAN; ENSEMBL ID: ENSG00000184661; HGNC ID: 14623
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C014024 2,4,5,2',4',5'-hexachlorobiphenyl 2,4,5,2',4',5'-hexachlorobiphenyl results in increased expression of CDCA2 mRNAincreases expression 20005886
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of CDCA2 proteinaffects expression 20106945
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of CDCA2 mRNAincreases expression 20713471
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of CDCA2 mRNAdecreases expression 20018196
20382639
D002251 Carbon Tetrachloride Carbon Tetrachloride results in increased expression of CDCA2 mRNAincreases expression 17484886
D016572 Cyclosporine Cyclosporine results in decreased expression of CDCA2 mRNAdecreases expression 20106945
D004137 Dinitrochlorobenzene Dinitrochlorobenzene results in increased expression of CDCA2 mRNAincreases expression 18242016
D008748 Methylcholanthrene Methylcholanthrene results in increased expression of CDCA2 mRNAincreases expression 20713471
D010081 Oxazolone Oxazolone results in increased expression of CDCA2 mRNAincreases expression 18242016
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of CDCA2 mRNAincreases expression 19465110
D014051 Toluene 2,4-Diisocyanate Toluene 2,4-Diisocyanate results in increased expression of CDCA2 mRNAincreases expression 18242016
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.0415322242 14514962 11752688
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 2.0120127859 20464547
MESH:D000236 Adenoma Benzo(a)pyrene 7.136695378
MESH:D000236 Adenoma Methylcholanthrene 7.1310545420 6695378
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.5716835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.0811748828
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.2519183758
MESH:D001249 Asthma Toluene 2,4-Diisocyanate 3.53170078 15590890 8156442 10934080 3040596 15590891 19187332 15855793 18394133 20032816 7684630 16792590 17015710 11467998 12762349 12585506 10797510 12684321 11077013 11742282 6091945 16210060 6091946
MESH:D050197 Atherosclerosis Methylcholanthrene 3.5311922910
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.1812125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.0115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8515746008
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.0320146248 17474063
MESH:D001943 Breast Neoplasms Methylcholanthrene 2.0317474063
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.0320435547
MESH:D001943 Breast Neoplasms Toluene 2,4-Diisocyanate 2.0311921183
MESH:D016535 Bronchial Hyperreactivity Toluene 2,4-Diisocyanate 4.6515590891 8156442 12507178
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.9516192424 16124888 16050911 16011737 10355542 16097048 15721981 15700767 18705752 15673190 16227642 3786805
MESH:D002277 Carcinoma Methylcholanthrene 8.7110545420
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 8.7116835633
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 3.1112907637 21507988 12619106
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 3.1118788625
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 2.0820419170
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4418850075 18670907 16120746
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 11.7920889678
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 11.7912371664
MESH:D002471 Cell Transformation, Neoplastic Methylcholanthrene 11.7916192471
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.2916835633
MESH:D002779 Cholestasis Cyclosporine 3.0219486331
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1512621046 15668235 15340226 16354765 8697196
MESH:D003093 Colitis, Ulcerative Dinitrochlorobenzene 3.8919159591 17373747
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.1817141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2610048152 15322242 20055451
MESH:D017449 Dermatitis, Allergic Contact Dinitrochlorobenzene 8.4015491423
MESH:D017449 Dermatitis, Allergic Contact Toluene 2,4-Diisocyanate 8.4012956900 18759878 15491423
MESH:D003877 Dermatitis, Contact Oxazolone 10.6915944321 12811023
MESH:D003877 Dermatitis, Contact Toluene 2,4-Diisocyanate 10.6917010967
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6917107852
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 3.8421278145 15027814 2869522 11566570 16177239 17522070 19085960 15998439 15968718 16227642 10915739 6623471 7440962 6884620 3732212 7179309 3786805 10092053 4309450 7120509 9327722 19336974
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 3.8420420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8611462148
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.5111000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.1216714409 15322242 18230668
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.1510568697 9294722
MESH:D004802 Eosinophilia Toluene 2,4-Diisocyanate 4.828156442
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 4.4620426865
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.4616530937
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.1211564622
MESH:D005128 Eye Diseases Toluene 2,4-Diisocyanate 5.9418447907
MESH:D005234 Fatty Liver Carbon Tetrachloride 8.1815959796 19224547 12631006 16239168 16045604 17595544 12795759 61145
MESH:D005234 Fatty Liver Cyclosporine 8.1819224547
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.6311858732
MESH:D005354 Fibrosarcoma Methylcholanthrene 5.1314633661 10962813
MESH:D005355 Fibrosis Carbon Tetrachloride 15.7718705752
MESH:D005355 Fibrosis Cyclosporine 15.7712168785 12639820
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 15.7720067830
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.418708960
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.8110696789
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 6.6720471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.6710048152 11294989
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.6215720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.4811000095
MESH:D006505 Hepatitis Carbon Tetrachloride 3.7619900420 19110552
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.0715340226 12621046 16120746
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.2615340226 16354765 8697196 18606429 16959395
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.7316899240
MESH:D006967 Hypersensitivity Toluene 2,4-Diisocyanate 4.7310880147 11019492
MESH:D006973 Hypertension Cyclosporine 5.1010903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.1018850075 18670907
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.2615338365
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 1.9212878042 12200463
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.4816580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.6615604871
MESH:D007674 Kidney Diseases Cyclosporine 2.418314463 10903974 18776723
MESH:D007680 Kidney Neoplasms Cyclosporine 2.8512371664
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 2.8816943688 17157831 16239168 17334410 11408273 11903743 17174718 16221502 21278145
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 2.3217976157 17805973 17565644 18251166 15650968 17922224 18054572 15362042 17823541 15730626 14716496 14748882 15925388 17869086 16116963 18187930 16015684 18472094 18263696 17557913 14620537 12586293 12389079 15673190 18317297 17766677 15959796 16248980 15893842 12898905 14512876 16638106 12445418 16192424 12666154 18412020 17698563 15818738 16011737 18210741 15370692 18277467 18006644 18472332 12649538 15931870 20821823 12546737 18705752 18339082 15057751 12741479 17944888 12632512 17721639 17481882 10355542 15338365 18279442 17631135 11481614 17714472 13678700 17761835 18205269 17708605 17900296 15123356 16097048 16136751 14724832 12632514 12958196 18376398 16033810 18395914 12609069 18395095 15996030 18420326 18166357 18481824 18418968 12667390 17525996 17640975 12445421 14716833 15876570 16027843 18156304 15052691 18429990
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.3212878042
MESH:D008107 Liver Diseases Carbon Tetrachloride 2.1115720792 17285989 15830285 16964402 16246199
MESH:D017093 Liver Failure Carbon Tetrachloride 4.3415123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 3.8216899240 14706259
MESH:D008113 Liver Neoplasms 2,4,5,2',4',5'-hexachlorobiphenyl 14.7816835634 18644402
MESH:D008113 Liver Neoplasms Aflatoxin B1 14.7815890375 18177683 9163691 2125692
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 14.7821137059 20195826
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 14.7819294768
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 14.7816984957
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 14.858603461
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 14.8515583823 12014681
MESH:D008114 Liver Neoplasms, Experimental Methylcholanthrene 14.85598648 1399818
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 14.8512151625
MESH:D008175 Lung Neoplasms Aflatoxin B1 4.9714755239
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 4.9720464547 20135361 18816296 20064080 18569708 18520028 17053015 6695378 20869020
MESH:D008175 Lung Neoplasms Methylcholanthrene 4.977750092 10545420 16337739 15390079 16271038 20512841 9230183 6695378 1399818 11893704 20970405 17909032 21163286
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 4.9719555203 11884234
MESH:D008545 Melanoma Dinitrochlorobenzene 3.2112202904 17334785
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.0116801185
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.3016381670
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.1312213967
MESH:D009369 Neoplasms 2,4,5,2',4',5'-hexachlorobiphenyl 5.668820588
MESH:D009369 Neoplasms Benzo(a)pyrene 5.6611141357
MESH:D009374 Neoplasms, Experimental Toluene 2,4-Diisocyanate 4.911670384
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.6617954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.4118481113 19348381
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.3714600291
MESH:D009784 Occupational Diseases Toluene 2,4-Diisocyanate 4.853040596 11077013 18394133 12585506 8156442 6091946 6091945
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.4712520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.7218163543
MESH:D011230 Precancerous Conditions Cyclosporine 3.3512371664
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.3811896295 11399792 11118676 11222880
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.9517292933
MESH:D011565 Psoriasis Cyclosporine 2.2716882103
MESH:D011657 Pulmonary Eosinophilia Toluene 2,4-Diisocyanate 5.8414606601
MESH:D012130 Respiratory Hypersensitivity Toluene 2,4-Diisocyanate 4.527692837 20219652 16940033
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.0018990726
MESH:D012140 Respiratory Tract Diseases Toluene 2,4-Diisocyanate 5.3318447907
MESH:D012220 Rhinitis Toluene 2,4-Diisocyanate 4.7119050374
MESH:D012221 Rhinitis, Allergic, Perennial Toluene 2,4-Diisocyanate 5.4912617775 15015336
MESH:D006255 Rhinitis, Allergic, Seasonal Toluene 2,4-Diisocyanate 5.7319075512
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 5.6719755658 10029692
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.6716192470
MESH:D012912 Sneezing Toluene 2,4-Diisocyanate 5.7319075512 19050374
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 1.5620155912 2093021
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.1212697716
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 2.2217053015
MESH:D014605 Uveitis Cyclosporine 4.201336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.8112125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.4715886252
MESH:D014985 Xerophthalmia Cyclosporine 4.6617120751
No data
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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