AutismKB 2.0

Annotation Detail for RDH10


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Basic Information Top
Gene Symbol:RDH10 ( SDR16C4 )
Gene Full Name: retinol dehydrogenase 10 (all-trans)
Band: 8q21.11
Quick LinksEntrez ID:157506; OMIM: 607599; Uniprot ID:RDH10_HUMAN; ENSEMBL ID: ENSG00000121039; HGNC ID: 19975
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa00830Retinol metabolism
hsa01100Metabolic pathways
No data
No data
No data
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in increased expression of RDH10 mRNAincreases expression 18648102
D000082 Acetaminophen Acetaminophen affects the expression of RDH10 mRNAaffects expression 17562736
D000643 Ammonium Chloride Ammonium Chloride affects the expression of RDH10 mRNAaffects expression 16483693
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of RDH10 mRNAaffects expression 17484886
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of RDH10 mRNAincreases expression 16872691
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of RDH10 mRNAaffects expression 17555576
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of RDH10 mRNAincreases expression 17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of RDH10 mRNAaffects cotreatment|increases expression 17942748
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of RDH10 mRNAaffects binding|increases activity|increases expression 19710929
D012172 Retinaldehyde RDH10 protein results in increased chemical synthesis of Retinaldehydeincreases chemical synthesis 17473173
C089730 rosiglitazone rosiglitazone results in increased expression of RDH10 mRNAincreases expression 16982809
C089730 rosiglitazone rosiglitazone results in increased expression of RDH10 proteinincreases expression 16982809
D013629 Tamoxifen Tamoxifen affects the expression of RDH10 mRNAaffects expression 17555576
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of RDH10 mRNAaffects cotreatment|increases expression 17942748
D014212 Tretinoin [PPARG protein results in increased expression of RDH10 protein] which results in increased chemical synthesis of Tretinoinincreases chemical synthesis|increases expression 16982809
D014801 Vitamin A RDH10 protein results in increased oxidation of Vitamin Aincreases oxidation 17473173
D014801 Vitamin A RDH10 protein results in increased oxidation of Vitamin Aincreases oxidation 16982809
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.7214745880
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.0015322242 11752688 14514962
MESH:D000015 Abnormalities, Multiple Vitamin A 4.9710992263
MESH:D000138 Acidosis Ammonium Chloride 3.7118287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.1217505938
MESH:D055371 Acute Lung Injury pirinixic acid 3.2318653653
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.8314692618
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 2.813712494
MESH:D018248 Adenoma, Liver Cell pirinixic acid 10.4216434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 10.4216835633
MESH:D000505 Alopecia Tretinoin 3.7015955085
MESH:D000544 Alzheimer Disease rosiglitazone 2.8719621015
MESH:D000740 Anemia Tetrachlorodibenzodioxin 9.3211748828
MESH:D000740 Anemia Vitamin A 9.3216960172
MESH:D018798 Anemia, Iron-Deficiency Vitamin A 4.9016960172
MESH:D000799 Angioedema Acetaminophen 4.0210982225
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.6011256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 7.4215885639
MESH:D001169 Arthritis, Experimental Tretinoin 7.4216412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.2916292516
MESH:D001249 Asthma Tretinoin 5.3216456186
MESH:D001249 Asthma Vitamin A 5.3216732791
MESH:D001321 Autistic Disorder Acetaminophen 1.4118445737
MESH:D001471 Barrett Esophagus Tretinoin 4.5316935849
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.191440618 11289319
MESH:D001778 Blood Coagulation Disorders pirinixic acid 15.9319483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 15.9312125929
MESH:D001778 Blood Coagulation Disorders Tretinoin 15.9316206674 16197459
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.9615340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8315746008
MESH:D001943 Breast Neoplasms Tamoxifen 1.8315668708 18629630 20065188 17893378 19288272 19155303 16873071 19221464 21152245 16202921 19084267 19289846 19244106 19189210 19066611 18815881 20859285 20135344 16273361 18984771 19200415 20544844 17261762 18351453 19011961 15565566 19487384 19142967 19059307 18855134 19410462 11161223 17440819 20005174 18821012 19103187 17242785 19115204 21138602 18425577 20390343 19189212 16818667 18997820 17049068
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.8320435547
MESH:D001943 Breast Neoplasms Tretinoin 1.8316873071 16443354 16166294
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 13.5416813970
MESH:D001997 Bronchopulmonary Dysplasia Vitamin A 13.5417377406 17426644
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.9218705752 16011737 15721981 16124888 15673190 16097048 3786805 16192424 16050911 16227642 15700767 10355542
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.8916835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.6419066611
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.3316168501
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 9.043581430 7296757
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 9.043084413
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 9.0418788625
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 9.0416924424
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 9.041917145
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.727296757
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 2.3216096774 16051514
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.7217572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4218850075 18670907 16120746
MESH:D002386 Cataract Acetaminophen 7.4310977129
MESH:D002386 Cataract Tretinoin 7.4317460283
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 2.837505956
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.7416129372
MESH:D015362 Child Nutrition Disorders Vitamin A 5.6516153327
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.2616835633
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 19.9719486331 9022650
MESH:D002779 Cholestasis Ethinyl Estradiol 19.9717681005 17110522 11677210 17333356 16105132 16919318 15861022
MESH:D002779 Cholestasis pirinixic acid 19.9719176532
MESH:D002779 Cholestasis Vitamin A 19.9716175620
MESH:D002822 Choriocarcinoma Tretinoin 5.3316461808
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 10.1615668235 15340226 8697196 12621046 16354765
MESH:D002972 Cleft Palate Tretinoin 10.169407595
MESH:D002972 Cleft Palate Vitamin A 10.1616054864
MESH:D003092 Colitis Tretinoin 3.8417035595
MESH:D003110 Colonic Neoplasms Vitamin A 3.0617219422 16267017
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.1614669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 3.9520055451 10048152 15322242
MESH:D019465 Craniofacial Abnormalities Tretinoin 3.959224671 16925845 9211117 17551590 14991402 10589399 9664655 8800419 9142499 9125849
MESH:D019465 Craniofacial Abnormalities Vitamin A 3.9510992263
MESH:D003711 Demyelinating Diseases Tamoxifen 4.5019031437
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 2.9412868966 8970840 8156756 2524372 11906362 11298694 18759878 14531868
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4718249437
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.613621924 2952479
MESH:D003920 Diabetes Mellitus rosiglitazone 4.4017446233
MESH:D003922 Diabetes Mellitus, Type 1 Vitamin A 3.5416506275
MESH:D003924 Diabetes Mellitus, Type 2 rosiglitazone 4.5812642470
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.5817107852
MESH:D003928 Diabetic Nephropathies Tamoxifen 3.5719279558
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 9.1918692083 18289764 7440962 18648102 6679447 6482804 1440618 8291058 9653073 9022650 11289319 9328219 16192314
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 9.1911739529 16393943 18713872 14725611 19923254 17906064 12540782 17522070 19739265 16781746 12594235 11421492 19420014 12392966 11529661 17562736 14550746 12958197 19164858 16177239 11461765 19370779 10663392 16485898 19416960 12705907 11743745 19085960 12153990 10915739 2444490 16081117 14986274 18071297 11287661 15968718 16109766 11834606 16227642 10774834 15619225
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 9.199327722 16177239 15998439 7440962 4309450 2869522 11566570 21278145 7120509 16227642 3786805 15968718 17522070 19085960 6623471 10915739 7179309 6884620 15027814 19336974 10092053 3732212
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 9.1920420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.2719426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8411462148
MESH:D015352 Dry Eye Syndromes Vitamin A 5.9616146918
MESH:C538011 Eales disease Vitamin A 5.799068938
MESH:D004480 Ectromelia Vitamin A 6.0016054864
MESH:D004487 Edema pirinixic acid 12.1212083418
MESH:D004487 Edema rosiglitazone 12.1212083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 12.1211000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 12.5316714409 18230668 15322242
MESH:D004489 Edema, Cardiac Tretinoin 12.5318230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 9.3712538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 9.3719031437
MESH:D016889 Endometrial Neoplasms Tamoxifen 7.6717893378 16202921 19155303 20544844
MESH:D016889 Endometrial Neoplasms Tretinoin 7.6716569247
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.1210568697 9294722
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 2.133581430
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 9.1111564622
MESH:D005124 Eye Abnormalities Tretinoin 9.1116938888 9664655
MESH:D005234 Fatty Liver Carbon Tetrachloride 25.9112631006 16239168 15959796 19224547 12795759 61145 16045604 17595544
MESH:D005234 Fatty Liver Ethinyl Estradiol 25.9115345470
MESH:D005234 Fatty Liver pirinixic acid 25.9119236843 20131406
MESH:D005234 Fatty Liver rosiglitazone 25.9119196556
MESH:D005234 Fatty Liver Tamoxifen 25.9119224547 14986274
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.3016709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.5911858732
MESH:D005327 Fetal Resorption Vitamin A 5.5416054864
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.196705139
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.6814745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.3419069698
MESH:D005355 Fibrosis Carbon Tetrachloride 15.6018705752
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 15.6020067830
MESH:D005355 Fibrosis Tretinoin 15.6017994277
MESH:D005756 Gastritis Acetaminophen 3.8516983495
MESH:D005909 Glioblastoma Tretinoin 3.0717312396
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.157505956
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.7710696789
MESH:D006258 Head and Neck Neoplasms Tretinoin 3.2616096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.3316084493
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 11.5810048152 11294989
MESH:D006330 Heart Defects, Congenital Tretinoin 11.5814991402 9664655
MESH:D006330 Heart Defects, Congenital Vitamin A 11.5816080930 10992263
MESH:D006333 Heart Failure pirinixic acid 2.6020558911
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.4411000095
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 9.656705139
MESH:D006505 Hepatitis Carbon Tetrachloride 9.6519110552 19900420
MESH:D006529 Hepatomegaly pirinixic acid 8.7319176532 16221962 18467677 19772884
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 8.7315340226 12621046 16120746
MESH:D006548 Hernia, Diaphragmatic Vitamin A 3.6516490937 15707848 16292552 16863852 17436238 16877224
MESH:D015658 HIV Infections Vitamin A 3.8716960176
MESH:D006679 HIV Seropositivity Vitamin A 5.7517209195
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.2218606429 16959395 16354765 15340226 8697196
MESH:D006930 Hyperalgesia Acetaminophen 13.6216870215
MESH:D006930 Hyperalgesia rosiglitazone 13.6212083418
MESH:D006930 Hyperalgesia Tretinoin 13.6216870215
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.6916899240
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.7116778211
MESH:D006943 Hyperglycemia pirinixic acid 3.2920558911
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.0815034207
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9418670907 18850075
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.2315338365
MESH:D006986 Hypervitaminosis A Vitamin A 6.3416054864
MESH:D007021 Hypospadias Ethinyl Estradiol 3.9516945680 16569931
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.5812013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.5617937319
MESH:D007249 Inflammation rosiglitazone 8.6912083418
MESH:D007249 Inflammation Tamoxifen 8.6919457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 8.6912878042 12200463
MESH:D007333 Insulin Resistance pirinixic acid 7.7316306350
MESH:D007333 Insulin Resistance rosiglitazone 7.7316306350
MESH:D007410 Intestinal Diseases Tretinoin 3.9017994277
MESH:D019586 Intracranial Hypertension Vitamin A 6.0015955940
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.198074119 9022650
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 10.3016580747
MESH:D007569 Jaw Abnormalities Tretinoin 10.3017551590 15992940
MESH:D007674 Kidney Diseases Acetaminophen 2.2612587719 15629191
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 7.696582329
MESH:D007680 Kidney Neoplasms Tamoxifen 7.6918625569
MESH:D007938 Leukemia Tretinoin 2.8217143497
MESH:D007951 Leukemia, Myeloid Tretinoin 3.8116482212 16932348 19285840
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 2.0916294345 17596541 19850784
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 3.2219225113 17217047 19029980 17712046 16766008 16891316 19075265 16788101 16331271 19642359 15748426 9834237 17301526 19035177 16935935 17294898 17368321 16140955 17506722 16823087 12679006 17649720 17361223 17339181 17107899
MESH:D017880 Limb Deformities, Congenital Tretinoin 8.769224671
MESH:D017880 Limb Deformities, Congenital Vitamin A 8.7616054864
MESH:D008064 Lipidoses Tamoxifen 3.2317567588 15342952
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 7.1916239168 16943688 21278145 11408273 17334410 17157831 16221502 11903743 17174718
MESH:D008103 Liver Cirrhosis Vitamin A 7.1916256175
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.2615034207 9327722
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 13.5314748882 12741479 18156304 17976157 18395914 18705752 17708605 13678700 17557913 16033810 16192424 18205269 12546737 17721639 18472094 17900296 18210741 15057751 17761835 15996030 15818738 17698563 15673190 16097048 12649538 18317297 16136751 15123356 16248980 16015684 17631135 15052691 12898905 18054572 15338365 16638106 12632514 18166357 18418968 14724832 17640975 15370692 12667390 12445418 12445421 20821823 18187930 10355542 15876570 17944888 17869086 17922224 17805973 16116963 17481882 12389079 12958196 17823541 18376398 12586293 17766677 18279442 18412020 16027843 17525996 14512876 18472332 15925388 15730626 15959796 18277467 18263696 12632512 14716833 15931870 14716496 17714472 14620537 18251166 15650968 18481824 18006644 12666154 12609069 18395095 17565644 15362042 11481614 18420326 16011737 18339082 15893842 18429990
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 13.5315474484
MESH:D008106 Liver Cirrhosis, Experimental Retinaldehyde 13.5316248980
MESH:D008106 Liver Cirrhosis, Experimental rosiglitazone 13.5315980055 17347453
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 13.5318564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 13.5312878042
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 13.5318397230 16248980
MESH:D008106 Liver Cirrhosis, Experimental Vitamin A 13.5316248980
MESH:D008107 Liver Diseases Acetaminophen 6.7712587719 19784758 11587558 19460945 16611625 12969438 19014921 16610002
MESH:D008107 Liver Diseases Carbon Tetrachloride 6.7715830285 16246199 16964402 17285989 15720792
MESH:D008107 Liver Diseases Vitamin A 6.7716175620
MESH:D008108 Liver Diseases, Alcoholic Vitamin A 5.2916762690
MESH:D017093 Liver Failure Carbon Tetrachloride 4.3015123358
MESH:D017114 Liver Failure, Acute Acetaminophen 9.7616871587 17185352
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 9.7616899240 14706259
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 10.9919294768
MESH:D008113 Liver Neoplasms pirinixic acid 10.9916377806 20007298 15890375
MESH:D008113 Liver Neoplasms Tamoxifen 10.9916684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 10.9916984957
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 14.71598648 3712494 6587162 1399818
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 14.7115583823 12014681
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 14.7112151625
MESH:D008114 Liver Neoplasms, Experimental Vitamin A 14.7117113696
MESH:D008171 Lung Diseases Vitamin A 4.1616863852
MESH:D008175 Lung Neoplasms Tamoxifen 2.2818625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 2.2811884234 19555203
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 3.9119428831
MESH:D008325 Mammary Neoplasms, Experimental rosiglitazone 6.5016827153
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 6.5019196722 11731420 16827153 14580682 19196723
MESH:D020149 Manganese Poisoning Tamoxifen 4.7219453300
MESH:D008527 Medulloblastoma Tretinoin 2.8217453147
MESH:D008545 Melanoma Tamoxifen 3.3419393235 12393984
MESH:D008545 Melanoma Tretinoin 3.3416752155
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.3415990972
MESH:D008546 Melanoma, Experimental Acetaminophen 3.7119513568
MESH:D008591 Meningomyelocele Tretinoin 4.5616940565
MESH:D024821 Metabolic Syndrome X rosiglitazone 4.4717261469
MESH:D009101 Multiple Myeloma Vitamin A 4.1316374440
MESH:D009135 Muscular Diseases pirinixic acid 3.6416239165
MESH:D009190 Myelodysplastic Syndromes Tretinoin 3.1417596541
MESH:D009203 Myocardial Infarction pirinixic acid 2.1819151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.1112213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.0316411023
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 5.833581430
MESH:D009362 Neoplasm Metastasis Tamoxifen 5.8319393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.5519410462
MESH:D009369 Neoplasms pirinixic acid 5.0817405874
MESH:D009369 Neoplasms Tretinoin 5.0816946489 16594593
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 4.1719196722 19200415 19189210
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 9.9414600291
MESH:D009421 Nervous System Malformations Tretinoin 9.949125849
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 12.666679447
MESH:D009436 Neural Tube Defects Tretinoin 12.669142499
MESH:D009436 Neural Tube Defects Vitamin A 12.6617400914
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.9618514411
MESH:D009765 Obesity pirinixic acid 1.8420558911
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 3.524026338 6482804
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.193988306
MESH:D010051 Ovarian Neoplasms Tretinoin 2.3716936753
MESH:D010146 Pain Acetaminophen 6.8916870215
MESH:D010146 Pain Tretinoin 6.8916870215
MESH:D010190 Pancreatic Neoplasms Tretinoin 2.5015976015
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.8011578682
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.627296757
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.4212520081
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.646228378
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.6918163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.3411118676 11399792 11222880 11896295
MESH:D011471 Prostatic Neoplasms Tamoxifen 3.1315067354
MESH:D011507 Proteinuria Tretinoin 3.7216636307
MESH:D011537 Pruritus Ethinyl Estradiol 3.4715861022 16919318
MESH:D011625 Pterygium Tretinoin 4.9516723453
MESH:D015427 Reperfusion Injury pirinixic acid 2.4319058328
MESH:D012127 Respiratory Distress Syndrome, Newborn Vitamin A 5.9616877224
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.9618990726
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.463692021
MESH:D012208 Rhabdomyosarcoma Tretinoin 4.2216283617 16116481
MESH:D012871 Skin Diseases Vitamin A 3.3818709164
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.7216192470
MESH:D012878 Skin Neoplasms Tretinoin 5.7216467112
MESH:D013088 Spermatocele Ethinyl Estradiol 12.1516709447
MESH:D013088 Spermatocele Tamoxifen 12.1516709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 4.1919457130
MESH:D013274 Stomach Neoplasms Tretinoin 1.8017261132
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.7411994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.2515669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.0812697716
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 7.416582329 3712494 1399818 6587162 7505956
MESH:D013964 Thyroid Neoplasms Tretinoin 7.4117045167 16026305
MESH:D014062 Tongue Neoplasms Tretinoin 3.8916051514
MESH:D014376 Tuberculosis Tretinoin 3.2916040207
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 5.168074119
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 5.168653321 17572228 16712894
MESH:D014581 Urticaria Acetaminophen 3.0910982225
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 3.7816129372
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.4214692618
MESH:D014604 Uveal Neoplasms Tretinoin 4.7816752155
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.7712125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.6514671159 15869587
MESH:D014802 Vitamin A Deficiency Vitamin A 5.3916960172 16146918 16175781
MESH:D014820 Vitiligo Tretinoin 4.1816761959
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.4215886252
MESH:D009396 Wilms Tumor Tretinoin 4.0716287080
Pathway ID Pathway Name
KEGG:01100 Metabolic pathways
KEGG:00830 Retinol metabolism
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Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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