AutismKB 2.0

Annotation Detail for FBXO16


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Basic Information Top
Gene Symbol:FBXO16 ( FBX16,MGC125923,MGC125924,MGC125925 )
Gene Full Name: F-box protein 16
Band: 8p21.1
Quick LinksEntrez ID:157574; OMIM: 608519; Uniprot ID:FBX16_HUMAN; ENSEMBL ID: ENSG00000214050; HGNC ID: 13618
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in decreased expression of FBXO16 mRNAdecreases expression 18648102
D000638 Amiodarone Amiodarone results in increased expression of FBXO16 mRNAincreases expression 19774075
D001104 Arbutin Arbutin results in increased expression of FBXO16 mRNAincreases expression 17103032
D016572 Cyclosporine Cyclosporine results in increased expression of FBXO16 mRNAincreases expression 20106945
C097613 imatinib [tetraarsenic tetrasulfide co-treated with imatinib] results in increased expression of FBXO16 mRNAaffects cotreatment|increases expression 19208803
C011890 kojic acid kojic acid results in increased expression of FBXO16 mRNAincreases expression 16595896
C534735 tetraarsenic tetrasulfide [tetraarsenic tetrasulfide co-treated with imatinib] results in increased expression of FBXO16 mRNAaffects cotreatment|increases expression 19208803
C534735 tetraarsenic tetrasulfide tetraarsenic tetrasulfide results in increased expression of FBXO16 mRNAincreases expression 19208803
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of FBXO16 mRNAdecreases expression 18495758
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.1814514962 15322242 11752688
MESH:D000015 Abnormalities, Multiple imatinib 5.5018322153
MESH:D000022 Abortion, Spontaneous imatinib 6.5918322153
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 2.883712494
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.7116835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.1711748828
MESH:D001145 Arrhythmias, Cardiac Amiodarone 4.0318218290 18057881 20041841
MESH:D001281 Atrial Fibrillation Amiodarone 4.0819698954 18651412
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.401440618 11289319
MESH:D001778 Blood Coagulation Disorders Amiodarone 9.8719483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 9.8712125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.1715340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.9115746008
MESH:D001859 Bone Neoplasms imatinib 5.5815867366
MESH:D001943 Breast Neoplasms imatinib 2.4817614352
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.4820435547
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.9916835633
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 1.777296757 3581430
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.777296757
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4918670907 18850075 16120746
MESH:D002311 Cardiomyopathy, Dilated Amiodarone 2.9619225199 15710769
MESH:D002341 Carotid Artery Thrombosis Amiodarone 5.4218974383
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 7.107505956
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 7.1012371664
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.3816835633
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 8.4719486331 9022650
MESH:D002779 Cholestasis Cyclosporine 8.4719486331
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.198697196 15668235 15340226 12621046 16354765
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.2714669216 17141729
MESH:D019465 Craniofacial Abnormalities imatinib 3.0218322153
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 3.0220055451 10048152 15322242
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 3.108156756 14531868 12868966 18759878 11906362 2524372 8970840 11298694
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.753621924 2952479
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7117107852
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 6.581440618 18289764 8291058 6679447 9653073 18692083 9328219 11289319 7440962 6482804 9022650 18648102 16192314
MESH:D056486 Drug-Induced Liver Injury Amiodarone 6.5815265979 18218290
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 6.5820420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.9311462148
MESH:D004487 Edema imatinib 8.0419703484
MESH:D004487 Edema Tetrachlorodibenzodioxin 8.0412711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.2815322242 16714409 18230668
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.2510568697 9294722
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 2.153581430
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.1911564622
MESH:D005234 Fatty Liver Amiodarone 8.6514986274
MESH:D005234 Fatty Liver Cyclosporine 8.6519224547
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.7611858732
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.406705139
MESH:D018222 Fibromatosis, Aggressive imatinib 5.9817453242
MESH:D005355 Fibrosis Cyclosporine 9.5212639820 12168785
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 9.5220067830
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.568708960
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.307505956
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.9710696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.4411294989 10048152
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.7615720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.5811000095
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.796705139
MESH:D006529 Hepatomegaly Amiodarone 9.5815265979
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 9.5812621046 15340226 16120746
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.428697196 16354765 18606429 15340226 16959395
MESH:D006937 Hypercholesterolemia Amiodarone 4.129751232 8137927
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.2515034207
MESH:D006973 Hypertension Cyclosporine 5.2110903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.2118670907 18850075
MESH:D007037 Hypothyroidism Amiodarone 4.8218020914 17991464
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 1.9612878042 12200463
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.408074119 9022650
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.5816580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.8215604871
MESH:D007674 Kidney Diseases Cyclosporine 2.4618776723 10903974 8314463
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 7.956582329
MESH:D007680 Kidney Neoplasms Cyclosporine 7.9512371664
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive imatinib 10.0515748426 17301526 15107311 19208803
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive tetraarsenic tetrasulfide 10.0519208803
MESH:D007951 Leukemia, Myeloid imatinib 5.3417236224
MESH:D008064 Lipidoses Amiodarone 3.6815342952 17567588
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.3315034207 9327722
MESH:D008106 Liver Cirrhosis, Experimental imatinib 2.8816596278
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.8812878042
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 1.7916984957
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 10.71598648 1399818 6587162 3712494
MESH:D008114 Liver Neoplasms, Experimental kojic acid 10.7118544905
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 10.7112151625
MESH:D008133 Long QT Syndrome Amiodarone 3.7611989578 17391786 15350150
MESH:D008171 Lung Diseases Amiodarone 3.5312587719
MESH:D017563 Lung Diseases, Interstitial Amiodarone 4.8518516814
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 1.2411884234 19555203
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.1616801185
MESH:D009181 Mycoses Amiodarone 5.2817974566 12754197
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.2112213967
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 6.513581430
MESH:D009362 Neoplasm Metastasis imatinib 6.5115867366
MESH:D009376 Neoplasms, Hormone-Dependent imatinib 5.8417614352
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.8217954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.5019348381 18481113
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.4914600291
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 3.066679447
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 3.656482804 4026338
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.403988306
MESH:D010014 Osteolysis imatinib 6.0715867366
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.797296757
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.6212520081
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.856228378
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.8418163543
MESH:D011230 Precancerous Conditions Cyclosporine 3.4412371664
MESH:D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma imatinib 4.6012476293
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.5311222880 11896295 11399792 11118676
MESH:D011565 Psoriasis Cyclosporine 2.3016882103
MESH:D011658 Pulmonary Fibrosis Amiodarone 2.9312490602 12832656 11597910
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.1218990726
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.553692021
OMIM:609620 SHORT QT SYNDROME 1 Amiodarone 5.4218724381
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.1416192470
MESH:D013274 Stomach Neoplasms imatinib 3.2015786421
MESH:D013276 Stomach Ulcer Amiodarone 3.5518087811
MESH:D013610 Tachycardia Amiodarone 4.5711238279
MESH:D017180 Tachycardia, Ventricular Amiodarone 4.4719225199
MESH:D013959 Thyroid Diseases Amiodarone 13.3419731979
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 13.3412697716
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 8.267505956 6582329 3712494 1399818 6587162
MESH:D013964 Thyroid Neoplasms imatinib 8.2616940797
MESH:D013971 Thyrotoxicosis Amiodarone 5.1718020914 19584973
MESH:D016171 Torsades de Pointes Amiodarone 4.5317467628 11989578
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 2.358074119
MESH:D014605 Uveitis Cyclosporine 4.361336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.9712125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.6215886252
MESH:D014985 Xerophthalmia Cyclosporine 4.8217120751
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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