AutismKB 2.0

Annotation Detail for CYP3A5


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Basic Information Top
Gene Symbol:CYP3A5 ( CP35,CYPIIIA5,DKFZp686L16231,FLJ31317,P450PCN3,PCN3 )
Gene Full Name: cytochrome P450, family 3, subfamily A, polypeptide 5
Band: 7q22.1
Quick LinksEntrez ID:1577; OMIM: 605325; Uniprot ID:CP3A5_HUMAN; ENSEMBL ID: ENSG00000106258; HGNC ID: 2638
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa00830Retinol metabolism
hsa00140Steroid hormone biosynthesis
hsa00980Metabolism of xenobiotics by cytochrome P450
hsa00982Drug metabolism - cytochrome P450
hsa00983Drug metabolism - other enzymes
hsa01100Metabolic pathways
hsa00591Linoleic acid metabolism
Pathway IDPathway Name
Biological oxidations
No data
No data
Pathway IDPathway Name
500197Xenobiotics
Related Diseases/Disorders Top
No data
No data
Desease Name
hypercholesterolemia
cholesterol
oral cancer
lung transplant complications
NORMALVARIATION
blood pressure, arterial
CARDIOVASCULAR
liver cancer
cholesterol, LDL
prostate cancer
nephropathy
muscle damage
CANCER
PHARMACOGENOMIC
kidney transplant
RENAL
breast cancer
thyroid cancer
IMMUNE
aflatoxin-albumin
METABOLIC
ABT-773 plasma levels
lung cancer
cyclosporine pharmacokinetics
cervical cancer
No data
Desease Name
Hypertension, salt-sensitive essential, susceptibility to
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C035342 1,4-naphthoquinone CYP3A5 protein results in increased abundance of 1,4-naphthoquinoneincreases abundance 16243959
C112765 17-(allylamino)-17-demethoxygeldanamycin CYP3A5 protein affects the metabolism of 17-(allylamino)-17-demethoxygeldanamycinaffects metabolic processing 15718306
C029350 1-naphthol CYP3A5 protein results in increased abundance of 1-naphtholincreases abundance 16243959
C038345 3-hydroxytamoxifen 3-hydroxytamoxifen results in decreased activity of CYP3A5 proteindecreases activity 12419016
C028657 3-methoxymorphinan CYP3A5 protein affects the chemical synthesis of 3-methoxymorphinanaffects chemical synthesis 15988119
C016601 4-hydroxytamoxifen 4-hydroxytamoxifen results in decreased activity of CYP3A5 proteindecreases activity 12419016
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of CYP3A5 proteinaffects expression 20106945
D016604 Aflatoxin B1 CYP3A5 protein results in increased activity of Aflatoxin B1increases activity 15454734
C027955 aflatoxin G1 CYP3A5 protein results in increased susceptibility to aflatoxin G1increases response to substance 11189750
D015760 Alfentanil CYB5 protein promotes the reaction [CYP3A5 protein affects the metabolism of Alfentanil]affects metabolic processing|increases reaction 15557344
D015760 Alfentanil CYP3A5 protein affects the metabolism of Alfentanilaffects metabolic processing 15731592
15557344
D015760 Alfentanil Ketoconazole inhibits the reaction [CYP3A5 protein affects the metabolism of Alfentanil]affects metabolic processing|decreases reaction 15731592
D015760 Alfentanil Troleandomycin inhibits the reaction [CYP3A5 protein affects the metabolism of Alfentanil]affects metabolic processing|decreases reaction 15731592
D000525 Alprazolam CYP3A5 protein results in increased hydroxylation of Alprazolamincreases hydroxylation 15903124
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of CYP3A5 mRNAincreases expression 20106945
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of CYP3A5 mRNAdecreases expression 20018196
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of CYP3A5 mRNAincreases expression 19150397
D002065 Buspirone CYP3A5 protein results in increased oxidation of Buspironeincreases oxidation 15640381
D002220 Carbamazepine Carbamazepine results in increased expression of CYP3A5 mRNAincreases expression 12673034
C035038 carbosulfan CYP3A5 protein results in increased metabolism of carbosulfanincreases metabolic processing 20307514
C088453 Celsior Celsior results in decreased expression of CYP3A5 mRNAdecreases expression 15448115
D020111 Chlorodiphenyl (54% Chlorine) Chlorodiphenyl (54% Chlorine) results in increased expression of CYP3A5 mRNAincreases expression 17851650
D004390 Chlorpyrifos Chlorpyrifos results in increased expression of CYP3A5 mRNAincreases expression 16757081
D004390 Chlorpyrifos CYP3A5 protein affects the metabolism of Chlorpyrifosaffects metabolic processing 17079358
17110060
C010087 cineole CYP3A5 protein results in increased hydroxylation of cineoleincreases hydroxylation 15715982
D002990 Clobetasol Clobetasol results in increased expression of CYP3A5 mRNAincreases expression 16882163
D003022 Clotrimazole Clotrimazole results in increased expression of CYP3A5 proteinincreases expression 8632764
D003345 Corticosterone Corticosterone results in increased metabolism of CYP3A5 proteinincreases metabolic processing 20032461
C059483 CQA 206-291 CYP3A5 protein results in increased metabolism of CQA 206-291increases metabolic processing 1346997
D016572 Cyclosporine Cyclosporine results in decreased expression of CYP3A5 mRNAdecreases expression 20106945
D016572 Cyclosporine Cyclosporine results in increased expression of CYP3A5 mRNAincreases expression 12673034
D016572 Cyclosporine CYP3A5 protein affects the metabolism of Cyclosporineaffects metabolic processing 15964336
15454731
15808586
15450954
D016572 Cyclosporine CYP3A5 protein polymorphism affects the metabolism of Cyclosporineaffects metabolic processing 15808586
C064445 dechloroethylcyclophosphamide CYP3A5 protein affects the chemical synthesis of dechloroethylcyclophosphamideaffects chemical synthesis 15875221
D003671 DEET CYP3A5 protein results in increased metabolism of DEETincreases metabolic processing 11854147
D003687 Dehydroepiandrosterone CYP3A5 protein results in increased hydroxylation of Dehydroepiandrosteroneincreases hydroxylation 15845858
D003907 Dexamethasone Dexamethasone results in increased expression of CYP3A5 mRNAincreases expression 10696073
D003917 Dextrorphan CYP3A5 protein affects the metabolism of Dextrorphanaffects metabolic processing 15988119
D003976 Diazinon Diazinon results in increased expression of CYP3A5 mRNAincreases expression 16757081
D002117 Calcitriol Calcitriol results in increased expression of CYP3A5 mRNAincreases expression 16002434
D004110 Diltiazem CYP3A5 protein affects the metabolism of Diltiazemaffects metabolic processing 16024008
D004110 Diltiazem CYP3A5 protein polymorphism affects the metabolism of Diltiazemaffects metabolic processing 16024008
D004110 Diltiazem CYP3A5 protein results in decreased methylation of Diltiazemdecreases methylation 15499178
D004121 Dimethyl Sulfoxide Dimethyl Sulfoxide affects the expression of CYP3A5 mRNAaffects expression 12843640
D004726 Endosulfan CYP3A5 protein affects the metabolism of Endosulfanaffects metabolic processing 16581944
D004917 Erythromycin CYP3A5 protein results in decreased methylation of Erythromycindecreases methylation 15383492
D004997 Ethinyl Estradiol CYP3A5 protein results in increased hydroxylation of Ethinyl Estradiolincreases hydroxylation 15304426
D005047 Etoposide CYP3A5 gene polymorphism affects the susceptibility to Etoposideaffects response to substance 12969965
D005047 Etoposide CYP3A5 protein results in decreased methylation of Etoposidedecreases methylation 8114683
D005284 Fenthion CYP3A5 protein affects the metabolism of Fenthionaffects metabolic processing 17110060
D005445 Flunitrazepam CYP3A5 protein results in increased hydroxylation of Flunitrazepamincreases hydroxylation 15383492
D005473 Fluoxetine Fluoxetine inhibits the reaction [CYP3A5 protein results in increased oxidation of and results in increased activity of Haloperidol]decreases reaction|increases activity|increases oxidation 12584149
D016666 Fluvoxamine Fluvoxamine inhibits the reaction [CYP3A5 protein results in increased oxidation of and results in increased activity of Haloperidol]decreases reaction|increases activity|increases oxidation 12584149
C419708 gefitinib CYP3A5 protein affects the metabolism of gefitinibaffects metabolic processing 15788367
D006220 Haloperidol CYP3A5 protein results in increased oxidation of and results in increased activity of Haloperidolincreases activity|increases oxidation 12584149
D006220 Haloperidol Fluoxetine inhibits the reaction [CYP3A5 protein results in increased oxidation of and results in increased activity of Haloperidol]decreases reaction|increases activity|increases oxidation 12584149
D006220 Haloperidol Fluvoxamine inhibits the reaction [CYP3A5 protein results in increased oxidation of and results in increased activity of Haloperidol]decreases reaction|increases activity|increases oxidation 12584149
D006220 Haloperidol nefazodone inhibits the reaction [CYP3A5 protein results in increased oxidation of and results in increased activity of Haloperidol]decreases reaction|increases activity|increases oxidation 12584149
D006220 Haloperidol norfluoxetine inhibits the reaction [CYP3A5 protein results in increased oxidation of and results in increased activity of Haloperidol]decreases reaction|increases activity|increases oxidation 12584149
D006220 Haloperidol Trazodone inhibits the reaction [CYP3A5 protein results in increased oxidation of and results in increased activity of Haloperidol]decreases reaction|increases activity|increases oxidation 12584149
D007069 Ifosfamide CYP3A5 protein affects the metabolism of Ifosfamideaffects metabolic processing 15875221
D007069 Ifosfamide CYP3A5 protein results in decreased ethylation of Ifosfamidedecreases ethylation 15821045
C051890 irinotecan [selenomethylselenocysteine co-treated with irinotecan] results in increased expression of CYP3A5affects cotreatment|increases expression 15897249
C051890 irinotecan CYP3A5 protein results in increased metabolism of irinotecanincreases metabolic processing 16271446
D007654 Ketoconazole Ketoconazole inhibits the reaction [CYP3A5 protein affects the metabolism of Alfentanil]affects metabolic processing|decreases reaction 15731592
D007654 Ketoconazole Ketoconazole results in decreased activity of CYP3A5 proteindecreases activity 15557344
D008012 Lidocaine CYP3A5 protein results in decreased methylation of Lidocainedecreases methylation 15383492
D008294 Malathion CYP3A5 protein affects the metabolism of Malathionaffects metabolic processing 17110060
D003915 Dextromethorphan CYP3A5 protein affects the metabolism of Dextromethorphanaffects metabolic processing 15988119
D003915 Dextromethorphan CYP3A5 protein results in decreased methylation of Dextromethorphandecreases methylation 15383492
D003915 Dextromethorphan CYP3A5 protein results in increased oxidation of Dextromethorphanincreases oxidation 15383492
D008874 Midazolam CYP3A5 protein affects the metabolism of Midazolamaffects metabolic processing 15801540
D008874 Midazolam CYP3A5 gene polymorphism affects the metabolism of Midazolamaffects metabolic processing 15900284
D008874 Midazolam CYP3A5 protein affects the metabolism of Midazolamaffects metabolic processing 15801540
15900284
19557931
D008874 Midazolam CYP3A5 protein results in increased hydroxylation of Midazolamincreases hydroxylation 15499178
15383492
D008874 Midazolam shengmaisan affects the reaction [CYP3A5 protein affects the metabolism of Midazolam]affects metabolic processing|affects reaction 19557931
D008874 Midazolam CYP3A5 protein affects the metabolism of Midazolamaffects metabolic processing 15801540
D009173 Mycophenolic Acid CYP3A5 protein results in increased methylation of Mycophenolic Acidincreases methylation 15570183
C028787 N-desmethyltamoxifen N-desmethyltamoxifen results in decreased activity of CYP3A5 proteindecreases activity 12419016
C051752 nefazodone nefazodone inhibits the reaction [CYP3A5 protein results in increased oxidation of and results in increased activity of Haloperidol]decreases reaction|increases activity|increases oxidation 12584149
D019888 Nelfinavir Nelfinavir results in decreased activity of CYP3A5 proteindecreases activity 15523003
C454678 N-ethyl-3-toluamide CYP3A5 protein results in increased chemical synthesis of N-ethyl-3-toluamideincreases chemical synthesis 11854147
C036139 norfluoxetine norfluoxetine inhibits the reaction [CYP3A5 protein results in increased oxidation of and results in increased activity of Haloperidol]decreases reaction|increases activity|increases oxidation 12584149
C016904 norverapamil norverapamil results in decreased activity of CYP3A5 proteindecreases activity 15689501
C025589 ochratoxin A CYP3A5 protein results in increased susceptibility to ochratoxin Aincreases response to substance 11189750
D010278 Parathion CYP3A5 protein affects the metabolism of Parathionaffects metabolic processing 12669189
17110060
17079358
D026023 Permethrin Permethrin results in increased expression of CYP3A5 mRNAincreases expression 19326768
D010622 Phencyclidine CYP3A5 protein affects the metabolism of Phencyclidineaffects metabolic processing 16782764
D010634 Phenobarbital Phenobarbital results in increased expression of CYP3A5 mRNAincreases expression 15629111
10696073
D010672 Phenytoin Phenytoin results in increased expression of CYP3A5 mRNAincreases expression 12673034
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of CYP3A5 mRNAaffects binding|increases activity|increases expression 19710929
D010936 Plant Extracts Plant Extracts results in decreased activity of CYP3A5 proteindecreases activity 15900287
D012110 Reserpine Reserpine results in increased expression of CYP3A5 proteinincreases expression 8632764
D012293 Rifampin Rifampin results in increased expression of CYP3A5 mRNAincreases expression 12040753
15681896
12673034
15629111
D019438 Ritonavir Ritonavir results in decreased activity of CYP3A5 proteindecreases activity 15523003
C087123 romidepsin CYP3A5 protein affects the metabolism of romidepsinaffects metabolic processing 15635176
D012643 Selenium Selenium results in decreased expression of CYP3A5 mRNAdecreases expression 19244175
C002979 selenomethylselenocysteine [selenomethylselenocysteine co-treated with irinotecan] results in increased expression of CYP3A5affects cotreatment|increases expression 15897249
C009252 shengmaisan shengmaisan affects the reaction [CYP3A5 protein affects the metabolism of Midazolam]affects metabolic processing|affects reaction 19557931
D016559 Tacrolimus CYP3A5 gene affects the susceptibility to Tacrolimusaffects response to substance 15723604
D016559 Tacrolimus CYP3A5 gene polymorphism affects the metabolism of Tacrolimusaffects metabolic processing 15919447
D016559 Tacrolimus CYP3A5 gene SNP affects the metabolism of Tacrolimusaffects metabolic processing 15729180
D016559 Tacrolimus CYP3A5 protein affects the metabolism of Tacrolimusaffects metabolic processing 15964336
15808586
15502717
D016559 Tacrolimus CYP3A5 protein polymorphism affects the metabolism of Tacrolimusaffects metabolic processing 15502717
15808586
D016559 Tacrolimus CYP3A5 protein results in decreased methylation of Tacrolimusdecreases methylation 15951320
D013629 Tamoxifen CYP3A5 protein affects the metabolism of Tamoxifenaffects metabolic processing 15596297
D013629 Tamoxifen CYP3A5 protein polymorphism affects the metabolism of Tamoxifenaffects metabolic processing 15596297
D013629 Tamoxifen Tamoxifen results in decreased activity of CYP3A5 proteindecreases activity 12419016
D013713 Teniposide CYP3A5 protein results in decreased methylation of Teniposidedecreases methylation 8114683
D016593 Terfenadine CYP3A5 protein affects the metabolism of Terfenadineaffects metabolic processing 15383492
D013739 Testosterone CYP3A5 protein results in increased hydroxylation of Testosteroneincreases hydroxylation 15876487
15845858
15499178
16012074
15383492
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of CYP3A5 mRNAincreases expression 20106945
D013852 Thiotepa CYP3A5 gene SNP affects the export of Thiotepaaffects export 19076156
D013852 Thiotepa CYP3A5 protein affects the susceptibility to Thiotepaaffects response to substance 19076156
D014196 Trazodone Trazodone inhibits the reaction [CYP3A5 protein results in increased oxidation of and results in increased activity of Haloperidol]decreases reaction|increases activity|increases oxidation 12584149
D013721 Triethylenephosphoramide CYP3A5 gene SNP affects the export of Triethylenephosphoramideaffects export 19076156
D013721 Triethylenephosphoramide CYP3A5 protein affects the susceptibility to Triethylenephosphoramideaffects response to substance 19076156
C057693 troglitazone troglitazone results in decreased expression of CYP3A5decreases expression 15618651
D014217 Troleandomycin Troleandomycin inhibits the reaction [CYP3A5 protein affects the metabolism of Alfentanil]affects metabolic processing|decreases reaction 15731592
D014217 Troleandomycin Troleandomycin results in decreased activity of CYP3A5 proteindecreases activity 15557344
D014217 Troleandomycin Troleandomycin results in decreased activity of CYP3A5decreases activity 10910959
D014700 Verapamil Verapamil results in decreased activity of CYP3A5 proteindecreases activity 15689501
D002762 Cholecalciferol CYP3A5 protein results in increased hydroxylation of Cholecalciferolincreases hydroxylation 16207822
D014810 Vitamin E Vitamin E results in decreased expression of CYP3A5 mRNAdecreases expression 19244175
D014859 Warfarin CYP3A5 gene polymorphism affects the susceptibility to Warfarinaffects response to substance 19752777
D014859 Warfarin CYP3A5 protein affects the susceptibility to Warfarinaffects response to substance 19752777
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 3.7314745880
MESH:D000014 Abnormalities, Drug-Induced Carbamazepine 13.978986270
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 13.976195326
MESH:D000014 Abnormalities, Drug-Induced Phenytoin 13.979118846 10563481 6195326 9677735 3425630 8986270
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 13.9715322242 11752688 14514962
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.1317505938
MESH:D055371 Acute Lung Injury pirinixic acid 2.3818653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 3.2420127859 20464547
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 3.2414692618
MESH:D000236 Adenoma Benzo(a)pyrene 2.146695378
MESH:D018248 Adenoma, Liver Cell Phenobarbital 12.6917620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 12.6916434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 12.6916835633
MESH:D000309 Adrenal Insufficiency Dehydroepiandrosterone 4.9817302879
MESH:D000382 Agricultural Workers' Diseases Chlorpyrifos 14.1317119214 11874814 16611668
MESH:D000382 Agricultural Workers' Diseases Diazinon 14.1316487989
MESH:D000382 Agricultural Workers' Diseases Malathion 14.1317119214 11874814
MESH:D000382 Agricultural Workers' Diseases Parathion 14.1317119214 11874814
OMIM:607154 ALLERGIC RHINITIS Terfenadine 4.9316037679
MESH:D000544 Alzheimer Disease Plant Extracts 4.1816962711
MESH:D000544 Alzheimer Disease Trazodone 4.1816856516 17897735
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.2511748828
MESH:D000787 Angina Pectoris Diltiazem 5.7715929820
MESH:D000987 Antisocial Personality Disorder Testosterone 5.047506515
MESH:D001008 Anxiety Disorders Fluoxetine 4.2718083778
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 3.2919183758
MESH:D001145 Arrhythmias, Cardiac Lidocaine 4.86513065
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 8.0511256880
MESH:D001161 Arteriosclerosis Reserpine 8.0510729376
MESH:D001169 Arthritis, Experimental Dexamethasone 9.1917659584
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 9.1915885639
MESH:D001169 Arthritis, Experimental Plant Extracts 9.1914686799
MESH:D050197 Atherosclerosis Phenytoin 3.4115136057
MESH:D001289 Attention Deficit Disorder with Hyperactivity Dextromethorphan 4.7617175572
MESH:D001321 Autistic Disorder Buspirone 2.5818056831
MESH:D001321 Autistic Disorder Fluoxetine 2.5818775368 19232924
MESH:D001321 Autistic Disorder Fluvoxamine 2.5819232924 18775368 12607287
MESH:D001321 Autistic Disorder Haloperidol 2.5819368416 18080171
MESH:D001327 Autoimmune Diseases Cholecalciferol 4.2516142846
MESH:D001714 Bipolar Disorder Carbamazepine 3.6620046352 17594078
MESH:D001778 Blood Coagulation Disorders pirinixic acid 6.3719483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 6.3712125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 2.9815340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.2015746008
MESH:D019046 Bone Marrow Neoplasms Etoposide 4.3514601052
MESH:D002545 Brain Ischemia Plant Extracts 3.9416041641
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 6.5620146248 17474063
MESH:D001943 Breast Neoplasms Calcitriol 6.5611237771
MESH:D001943 Breast Neoplasms Etoposide 6.5616322251
MESH:D001943 Breast Neoplasms Malathion 6.5612762645
MESH:D001943 Breast Neoplasms ochratoxin A 6.5611921183
MESH:D001943 Breast Neoplasms Parathion 6.5612762645
MESH:D001943 Breast Neoplasms Reserpine 6.5611921183
MESH:D001943 Breast Neoplasms selenomethylselenocysteine 6.5618855134
MESH:D001943 Breast Neoplasms Tamoxifen 6.5620005174 20390343 18855134 18821012 18351453 18997820 19011961 20065188 19115204 19066611 15668708 19487384 11161223 17049068 20135344 19244106 18629630 16818667 20544844 17261762 15565566 17440819 19155303 19103187 18984771 17242785 18425577 19410462 16202921 19059307 19142967 21138602 19289846 16273361 18815881 19288272 19200415 19189212 16873071 20859285 19084267 19189210 19221464 21152245 17893378
MESH:D001943 Breast Neoplasms Testosterone 6.5617261762
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 6.5620435547
MESH:D002057 Burns, Chemical Plant Extracts 4.529625245
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 3.1616050911
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.1516835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 3.7219066611
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 5.0121507988 12907637 12619106
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 5.011701930 17173139 6705139 20935162 20007298
MESH:D006528 Carcinoma, Hepatocellular Plant Extracts 5.0118834353
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 5.0116924424
MESH:D002289 Carcinoma, Non-Small-Cell Lung gefitinib 3.6118347146 19233551 20005069 16230376 15496427 17290066
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 3.6420419170
MESH:D002294 Carcinoma, Squamous Cell Calcitriol 3.6411237771
MESH:D002295 Carcinoma, Transitional Cell romidepsin 7.8017230511
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 7.8017572228
MESH:D006332 Cardiomegaly Plant Extracts 5.2817645561
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 5.2816120746 18670907 18850075
MESH:D002318 Cardiovascular Diseases Tacrolimus 4.0317703430
MESH:D002340 Carotid Artery Diseases shengmaisan 5.9719557931
MESH:D002375 Catalepsy Haloperidol 4.1115215559 1977408
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 4.6020889678
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 4.6012371664
MESH:D002493 Central Nervous System Diseases Phenobarbital 9.084080065
MESH:D002493 Central Nervous System Diseases Phenytoin 9.084080065
MESH:D002543 Cerebral Hemorrhage Warfarin 5.0811061249
MESH:D002637 Chest Pain Trazodone 5.2115238202
MESH:D002653 Child Behavior Disorders Dextromethorphan 6.4217175572
MESH:D002659 Child Development Disorders, Pervasive Testosterone 3.3220678186
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 2.4716835633
MESH:D002779 Cholestasis Cyclosporine 9.7119486331
MESH:D002779 Cholestasis Ethinyl Estradiol 9.7117110522 16919318 17681005 16105132 15861022 17333356 11677210
MESH:D002779 Cholestasis pirinixic acid 9.7119176532
OMIM:601042 CHOREOATHETOSIS/SPASTICITY, EPISODIC Phenytoin 5.0711748493
MESH:D002971 Cleft Lip Phenytoin 3.672227380
MESH:D002972 Cleft Palate Phenytoin 4.772227380 6862529 1687470 3877104 6856622 10789828
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 4.7715668235 15340226 16354765 12621046 8697196
MESH:D003092 Colitis Selenium 3.0117936198
MESH:D003103 Coloboma Phenytoin 4.429212184
MESH:D003110 Colonic Neoplasms 17-(allylamino)-17-demethoxygeldanamycin 4.8215993848
MESH:D003110 Colonic Neoplasms Dexamethasone 4.8215824018
MESH:D003110 Colonic Neoplasms irinotecan 4.8217287894 17725105
MESH:D015179 Colorectal Neoplasms gefitinib 2.9117594712
MESH:D015179 Colorectal Neoplasms irinotecan 2.9116303861 16391804 17454858 17159606 15273666 18259882 18509181
MESH:D003128 Coma Trazodone 5.3210836866
MESH:D000013 Congenital Abnormalities Phenytoin 7.0910627286
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 7.0917141729 14669216
MESH:D023903 Coronary Restenosis Warfarin 4.9112872399
MESH:D003371 Cough Dextromethorphan 5.3317323712
OMIM:122700 COUMARIN RESISTANCE Warfarin 5.0720579077 20497562
MESH:D019465 Craniofacial Abnormalities Carbamazepine 9.479014606
MESH:D019465 Craniofacial Abnormalities Dexamethasone 9.4717728286
MESH:D019465 Craniofacial Abnormalities ochratoxin A 9.4720036863
MESH:D019465 Craniofacial Abnormalities Permethrin 9.4719861644
MESH:D019465 Craniofacial Abnormalities Phenytoin 9.4719952982 8986270 9212184
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 9.4710048152 20055451 15322242
MESH:D019465 Craniofacial Abnormalities Vitamin E 9.4719769572
MESH:D003490 Cyanosis Endosulfan 4.767900959
MESH:D016757 Death, Sudden, Cardiac Haloperidol 4.1020210726
MESH:D003704 Dementia Haloperidol 8.1911575062
MESH:D003704 Dementia Trazodone 8.1911575062 12587811
MESH:D003711 Demyelinating Diseases Tamoxifen 3.5819031437
MESH:D003866 Depressive Disorder Fluoxetine 13.6915014590
MESH:D003866 Depressive Disorder Fluvoxamine 13.6919571598
MESH:D003866 Depressive Disorder nefazodone 13.6918083778 16410371
MESH:D003866 Depressive Disorder Trazodone 13.6915014590 18083778 20305041 3378227 19623435 4066620 3690436
MESH:D003865 Depressive Disorder, Major Fluvoxamine 8.8017474826
MESH:D003865 Depressive Disorder, Major Trazodone 8.8016968574
MESH:D017449 Dermatitis, Allergic Contact Dexamethasone 2.6912438553
MESH:D003876 Dermatitis, Atopic pirinixic acid 1.9918249437
MESH:D003877 Dermatitis, Contact Permethrin 4.2514617103
MESH:D018500 Diabetes Insipidus, Nephrogenic 17-(allylamino)-17-demethoxygeldanamycin 5.4618854434
MESH:D003922 Diabetes Mellitus, Type 1 Dehydroepiandrosterone 5.2916616286
MESH:D003922 Diabetes Mellitus, Type 1 Warfarin 5.2918772604
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 3.8017107852
MESH:D003924 Diabetes Mellitus, Type 2 troglitazone 3.8016023994
MESH:D003925 Diabetic Angiopathies troglitazone 4.8612601628
MESH:D003928 Diabetic Nephropathies Plant Extracts 11.3319706694
MESH:D003928 Diabetic Nephropathies Tamoxifen 11.3319279558
MESH:D003928 Diabetic Nephropathies Warfarin 11.3312644472
MESH:D003967 Diarrhea Dexamethasone 2.977237001
OMIM:607208 DRAVET SYNDROME Carbamazepine 9.8111748493
OMIM:607208 DRAVET SYNDROME Phenytoin 9.8111748493
MESH:D003875 Drug Eruptions Phenytoin 10.3815024534
MESH:D003875 Drug Eruptions Warfarin 10.3814723717
MESH:D004342 Drug Hypersensitivity Carbamazepine 3.8616538175 20216337 15057820 16538176
MESH:D056486 Drug-Induced Liver Injury Carbamazepine 13.6217465707
MESH:D056486 Drug-Induced Liver Injury Chlorodiphenyl (54% Chlorine) 13.6217851650
MESH:D056486 Drug-Induced Liver Injury Ketoconazole 13.6218289764
MESH:D056486 Drug-Induced Liver Injury Ritonavir 13.6214986274
MESH:D056486 Drug-Induced Liver Injury Selenium 13.6215131321
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 13.6220420201
MESH:D056486 Drug-Induced Liver Injury troglitazone 13.6214986274
MESH:D004362 Drug Toxicity Carbamazepine 6.3120216337
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 6.3111462148
MESH:D004381 Duodenal Ulcer Tacrolimus 4.3917202747
MESH:D004409 Dyskinesia, Drug-Induced Trazodone 5.123690436
MESH:D004417 Dyspnea Diazinon 8.2316487989
MESH:D004417 Dyspnea Endosulfan 8.237900959 3388749
MESH:D004421 Dystonia Phenobarbital 8.551851702
MESH:D004421 Dystonia Trazodone 8.553700695
MESH:C538011 Eales disease Vitamin E 3.899068938
MESH:D004485 Eczema Dexamethasone 3.7012438553
MESH:D004487 Edema Dexamethasone 17.8719703484
MESH:D004487 Edema Fluoxetine 17.8712798668
MESH:D004487 Edema pirinixic acid 17.8712083418
MESH:D004487 Edema Plant Extracts 17.8712787963
MESH:D004487 Edema Tetrachlorodibenzodioxin 17.8711000095 12711302
MESH:D004487 Edema Trazodone 17.8712798668
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.0916714409 18230668 15322242
MESH:D004646 Emphysema Endosulfan 5.747900959
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Calcitriol 20.7715138306
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Carbamazepine 20.7717654737
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 20.7712538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Phenytoin 20.7717654737
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 20.7719031437
MESH:D018159 Endolymphatic Hydrops Dimethyl Sulfoxide 5.7420641076
MESH:D016889 Endometrial Neoplasms 4-hydroxytamoxifen 5.9019148513
MESH:D016889 Endometrial Neoplasms Tamoxifen 5.9019155303 16202921 17893378 20544844
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.329294722 10568697
MESH:D004719 Endomyocardial Fibrosis Plant Extracts 4.8715268973
MESH:D004816 Epidermal Necrolysis, Toxic Carbamazepine 9.1918855540 16538176 16415921 19915237 20485159
MESH:D004816 Epidermal Necrolysis, Toxic Phenytoin 9.1920235791
MESH:D004820 Epidermolysis Bullosa Phenytoin 5.421399206 6251365
MESH:D004831 Epilepsies, Myoclonic Carbamazepine 8.5917275665
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 8.593659116
MESH:D004828 Epilepsies, Partial Carbamazepine 12.4317116037 16628512 15008574
MESH:D004828 Epilepsies, Partial Phenobarbital 12.4311558140 3922381
MESH:D004828 Epilepsies, Partial Phenytoin 12.4311558140 17116037
MESH:D004827 Epilepsy Carbamazepine 11.879014606 17465707 19700373 821787 19620853 20417680 19439326 7988514 17178248 18234410
MESH:D004827 Epilepsy Phenobarbital 11.8720417680
MESH:D004827 Epilepsy Phenytoin 11.87821787 20417680 11434505
MESH:D004827 Epilepsy Plant Extracts 11.8719439326 19700373
MESH:D004832 Epilepsy, Absence Phenobarbital 2.866401628
MESH:D017029 Epilepsy, Complex Partial Carbamazepine 15.067750514
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 15.067750514
MESH:D017029 Epilepsy, Complex Partial Phenytoin 15.067750514
MESH:D004830 Epilepsy, Tonic-Clonic Carbamazepine 13.4315276670 3659116
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 13.433659116
MESH:D004830 Epilepsy, Tonic-Clonic Phenytoin 13.433659116
MESH:D007172 Erectile Dysfunction Trazodone 4.727604472
MESH:D004916 Erythromelalgia Carbamazepine 4.9219549232
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 3.3920426865
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 3.3916530937
MESH:D020329 Essential Tremor Trazodone 5.313296121
MESH:D005076 Exanthema Carbamazepine 4.6720485159
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.3811564622
MESH:D005198 Fanconi Syndrome Ifosfamide 5.7917481685
MESH:D005234 Fatty Liver Cyclosporine 17.0719224547
MESH:D005234 Fatty Liver Ethinyl Estradiol 17.0715345470
MESH:D005234 Fatty Liver pirinixic acid 17.0719236843 20131406
MESH:D005234 Fatty Liver Plant Extracts 17.0715975614
MESH:D005234 Fatty Liver Tamoxifen 17.0719224547 14986274
MESH:D052776 Female Urogenital Diseases Tamoxifen 2.6916709447
MESH:D005313 Fetal Death Phenytoin 8.1510627286
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 8.1511858732
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 3.7314745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 3.3819069698
MESH:D005355 Fibrosis Cyclosporine 5.9212168785 12639820
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 5.9220067830
MESH:D005391 Firesetting Behavior Testosterone 5.047506515
MESH:D005499 Folliculitis Clobetasol 6.551671328
MESH:D006471 Gastrointestinal Hemorrhage Warfarin 5.9011794436
MESH:D005776 Gaucher Disease Warfarin 5.1912359135
MESH:D005885 Gingival Hyperplasia Cyclosporine 10.268708960
MESH:D005885 Gingival Hyperplasia Phenytoin 10.269029455
MESH:D019214 Gingival Overgrowth Phenytoin 5.4216390469 14659971
MESH:D005909 Glioblastoma Testosterone 3.4917162496
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 3.7810696789
MESH:D006086 Graft vs Host Disease Tacrolimus 5.0916376943
MESH:D006130 Growth Disorders Tacrolimus 4.3511041285
MESH:D034381 Hearing Loss Dimethyl Sulfoxide 4.4820641076
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 8.2320471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 8.2310048152 11294989
MESH:D006330 Heart Defects, Congenital Vitamin E 8.2316080930
MESH:D006333 Heart Failure pirinixic acid 8.6820558911
MESH:D006333 Heart Failure Plant Extracts 8.6818097624
MESH:D006333 Heart Failure Selenium 8.6817162251
MESH:D006406 Hematoma Warfarin 5.9017493413
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 3.6215720958
MESH:D006470 Hemorrhage Endosulfan 13.327900959
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 13.3211000095
MESH:D006470 Hemorrhage Warfarin 13.3218429757
MESH:D006505 Hepatitis Diazinon 3.8216487989
MESH:D006529 Hepatomegaly Phenobarbital 9.9116109766
MESH:D006529 Hepatomegaly pirinixic acid 9.9118467677 16221962 19772884 19176532
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 9.9116120746 15340226 12621046
MESH:D006548 Hernia, Diaphragmatic Dexamethasone 4.757520565
MESH:D006548 Hernia, Diaphragmatic Vitamin E 4.7516490937 16863852
MESH:D006561 Herpes Simplex Etoposide 7.6310809021
MESH:D006561 Herpes Simplex Plant Extracts 7.6310715843
MESH:D006628 Hirsutism Testosterone 4.8417019078
MESH:D015658 HIV Infections Nelfinavir 8.4911362904 15388451
MESH:D015658 HIV Infections Plant Extracts 8.4912878215
MESH:D015658 HIV Infections Ritonavir 8.4915388451 11363243 17378895 11141242
MESH:D006689 Hodgkin Disease Etoposide 6.1115147373 17606976 18180244 16200630 16135485
MESH:D006689 Hodgkin Disease Ifosfamide 6.1116135485
MESH:D019584 Hot Flashes Fluoxetine 17.9114716179
MESH:D019584 Hot Flashes Plant Extracts 17.9116566672 14716179 17454163
MESH:D019584 Hot Flashes Trazodone 17.9119711746
MESH:D019584 Hot Flashes Vitamin E 17.9114716179
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.2316354765 8697196 18606429 15340226 16959395
MESH:D006930 Hyperalgesia Trazodone 4.2312790215
MESH:D017588 Hyperandrogenism Testosterone 4.4917019078
MESH:D006943 Hyperglycemia pirinixic acid 2.4820558911
MESH:D020138 Hyperhomocysteinemia Carbamazepine 11.7510459572
MESH:D020138 Hyperhomocysteinemia Phenytoin 11.7510459572
MESH:D020138 Hyperhomocysteinemia Plant Extracts 11.7516484555
MESH:D006949 Hyperlipidemias Plant Extracts 3.7415975614 15268973
MESH:D006965 Hyperplasia Carbamazepine 4.4318773962
MESH:D006967 Hypersensitivity Terfenadine 4.542570798
MESH:D006973 Hypertension Cyclosporine 9.2110903974
MESH:D006973 Hypertension Dexamethasone 9.2117042910
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 9.2118670907 18850075
MESH:D006973 Hypertension Verapamil 9.2117700361
OMIM:145500 HYPERTENSION, ESSENTIAL marker/mechanism
MESH:D006976 Hypertension, Pulmonary gefitinib 7.0118424623
MESH:D006976 Hypertension, Pulmonary Warfarin 7.0112359135
MESH:D017380 Hypertrophy, Right Ventricular gefitinib 5.4318424623
MESH:D007006 Hypogonadism Testosterone 3.9812002444
MESH:C537153 Hypomagnesemia primary Tacrolimus 5.3511041285
MESH:D007018 Hypopituitarism Testosterone 5.3817426086
MESH:D007021 Hypospadias Ethinyl Estradiol 3.0316945680 16569931
MESH:D007022 Hypotension Tacrolimus 4.3811041285
MESH:D007024 Hypotension, Orthostatic Trazodone 5.2115811171
MESH:D007035 Hypothermia Reserpine 5.511977408
MESH:D007174 Impulse Control Disorders Testosterone 5.047506515
MESH:D007247 Infertility, Female Ethinyl Estradiol 2.7212013081
MESH:D007248 Infertility, Male Diazinon 11.4512948887 16466525
MESH:D007248 Infertility, Male Endosulfan 11.459432128 8588293
MESH:D007248 Infertility, Male Ethinyl Estradiol 11.4517937319
MESH:D007248 Infertility, Male Parathion 11.4516029889
MESH:D007249 Inflammation Dexamethasone 16.7911099482 8960868
MESH:D007249 Inflammation Erythromycin 16.7919502290
MESH:D007249 Inflammation Fluoxetine 16.7912798668
MESH:D007249 Inflammation Plant Extracts 16.7916366677 12787963 15997105 19332304
MESH:D007249 Inflammation Tamoxifen 16.7919457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 16.7912878042 12200463
MESH:D007249 Inflammation Trazodone 16.7912798668
MESH:D007251 Influenza, Human Selenium 8.2616624496
MESH:D007251 Influenza, Human Vitamin E 8.2616624496
MESH:D007299 Insect Bites and Stings Permethrin 5.0112971516 12749493 15189238
MESH:D007333 Insulin Resistance pirinixic acid 2.0716306350
MESH:D007414 Intestinal Neoplasms Plant Extracts 3.9112584176 12351151 12628509
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 2.6116580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 3.6315604871
MESH:D007674 Kidney Diseases Cyclosporine 13.5918776723 10903974 8314463
MESH:D007674 Kidney Diseases Ifosfamide 13.5917035713 16221203
MESH:D007674 Kidney Diseases ochratoxin A 13.5911409539
MESH:D007674 Kidney Diseases Tacrolimus 13.5911041285
MESH:D007674 Kidney Diseases Vitamin E 13.5912488133
MESH:D007676 Kidney Failure, Chronic Selenium 3.1616518626
MESH:D007680 Kidney Neoplasms Cyclosporine 12.4412371664
MESH:D007680 Kidney Neoplasms gefitinib 12.4418625569
MESH:D007680 Kidney Neoplasms ochratoxin A 12.4416251485
MESH:D007680 Kidney Neoplasms Tamoxifen 12.4418625569
MESH:D007859 Learning Disorders Endosulfan 4.338157075
MESH:D016773 Leishmaniasis, Cutaneous Ketoconazole 4.032166429 19744259 8889330 1311351
MESH:D007898 Leishmaniasis, Visceral Ketoconazole 3.9211332679
MESH:D007938 Leukemia Permethrin 3.6712937054
MESH:D004915 Leukemia, Erythroblastic, Acute troglitazone 5.3316085563
MESH:D007945 Leukemia, Lymphoid Thiotepa 5.4810069464
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell Ritonavir 4.7816174765
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive Thiotepa 4.5810373061
MESH:D007951 Leukemia, Myeloid Thiotepa 4.8110069464
MESH:D008064 Lipidoses Fluoxetine 9.9217567588 15342952
MESH:D008064 Lipidoses Ketoconazole 9.9217567588
MESH:D008064 Lipidoses Tamoxifen 9.9217567588 15342952
MESH:D054068 Livedo Reticularis Warfarin 5.9018280355
MESH:D008103 Liver Cirrhosis Phenobarbital 5.2921047994
MESH:D008103 Liver Cirrhosis Plant Extracts 5.2917157831
MESH:D008106 Liver Cirrhosis, Experimental Dexamethasone 8.4016718785
MESH:D008106 Liver Cirrhosis, Experimental Dimethyl Sulfoxide 8.4011682029
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 8.4015474484
MESH:D008106 Liver Cirrhosis, Experimental Plant Extracts 8.4015479170
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 8.4018564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 8.4012878042
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 8.4016169303
MESH:D008107 Liver Diseases Chlorpyrifos 7.0815991261
MESH:D008107 Liver Diseases Phenobarbital 7.0819363144
MESH:D008107 Liver Diseases Phenytoin 7.0814986274
MESH:D008107 Liver Diseases Plant Extracts 7.0817034775
MESH:D017114 Liver Failure, Acute Trazodone 4.7019857765
MESH:D008113 Liver Neoplasms Aflatoxin B1 19.0318177683 2125692 9163691 15890375
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 19.0320195826 21137059
MESH:D008113 Liver Neoplasms Dehydroepiandrosterone 19.0318709148
MESH:D008113 Liver Neoplasms Phenobarbital 19.038742319 19812893 19073162 15975961 21047994 19482888
MESH:D008113 Liver Neoplasms pirinixic acid 19.0315890375 20007298 16377806
MESH:D008113 Liver Neoplasms Plant Extracts 19.0319168119
MESH:D008113 Liver Neoplasms Tamoxifen 19.0316684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 19.0316984957
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 9.648603461
MESH:D008114 Liver Neoplasms, Experimental Dehydroepiandrosterone 9.648603461
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 9.6418308698 1399818 2563599 6150874 17172636
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 9.6412151625
MESH:D008133 Long QT Syndrome Terfenadine 7.218772706
MESH:D008133 Long QT Syndrome Trazodone 7.2118167038
MESH:D008171 Lung Diseases Vitamin E 2.6016863852
MESH:D008175 Lung Neoplasms Aflatoxin B1 8.2114755239
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 8.2120464547 6695378 18816296 18520028 18569708 20135361 20064080 17053015 20869020
MESH:D008175 Lung Neoplasms Dexamethasone 8.2115824018 11195469
MESH:D008175 Lung Neoplasms Plant Extracts 8.2120869020
MESH:D008175 Lung Neoplasms Tamoxifen 8.2118625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 8.2119555203 11884234
MESH:D008175 Lung Neoplasms Vitamin E 8.2111062179
MESH:D008178 Lupus Erythematosus, Cutaneous Rifampin 5.3311422169
MESH:D008180 Lupus Erythematosus, Systemic Carbamazepine 5.1116628512
MESH:D008180 Lupus Erythematosus, Systemic Rifampin 5.1111422169
MESH:D008223 Lymphoma Etoposide 6.4412854902 12556972
MESH:D008223 Lymphoma Thiotepa 6.4410069464
MESH:D017728 Lymphoma, Large-Cell, Anaplastic 17-(allylamino)-17-demethoxygeldanamycin 5.8117157164
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 2.9719428831
MESH:D008325 Mammary Neoplasms, Experimental Corticosterone 23.6612807724
MESH:D008325 Mammary Neoplasms, Experimental Dehydroepiandrosterone 23.6616457693
MESH:D008325 Mammary Neoplasms, Experimental gefitinib 23.6618375820
MESH:D008325 Mammary Neoplasms, Experimental ochratoxin A 23.6611921183
MESH:D008325 Mammary Neoplasms, Experimental Reserpine 23.6611921183
MESH:D008325 Mammary Neoplasms, Experimental Selenium 23.6615318939
MESH:D008325 Mammary Neoplasms, Experimental selenomethylselenocysteine 23.6615318939
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 23.6619196723 19196722 16827153 14580682 11731420
MESH:D020149 Manganese Poisoning Tamoxifen 3.7319453300
MESH:D008545 Melanoma Tamoxifen 1.7619393235 12393984
MESH:D018328 Melanoma, Amelanotic Tamoxifen 3.3815990972
MESH:D001523 Mental Disorders Fluoxetine 16.3016856516
MESH:D001523 Mental Disorders Fluvoxamine 16.3016856516
MESH:D001523 Mental Disorders Haloperidol 16.3016856516
MESH:D001523 Mental Disorders norfluoxetine 16.3016856516
MESH:D001523 Mental Disorders Trazodone 16.3016856516
MESH:D008607 Mental Retardation Carbamazepine 5.349014606
MESH:D008607 Mental Retardation Phenytoin 5.349212184
MESH:D008654 Mesothelioma Selenium 2.4015107826
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 3.9716801185
MESH:D008708 Methemoglobinemia Lidocaine 4.873537620
MESH:D008850 Microphthalmos ochratoxin A 5.0320036863
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 2.5516381670
MESH:D009069 Movement Disorders Trazodone 5.024066620
MESH:D052016 Mucositis irinotecan 4.2117159606
MESH:D009101 Multiple Myeloma Dexamethasone 2.9116118317 15867202 15744524
MESH:D009135 Muscular Diseases pirinixic acid 2.7316239165
MESH:D009164 Mycobacterium Infections Rifampin 9.0318474467
MESH:D009164 Mycobacterium Infections Ritonavir 9.0321442799
MESH:D009190 Myelodysplastic Syndromes Dexamethasone 3.029809623
MESH:D009203 Myocardial Infarction pirinixic acid 1.7519151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.3612213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 2.3116411023
MESH:D009205 Myocarditis shengmaisan 6.2919557931
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 9.8417484760
MESH:D020191 Myoclonic Epilepsies, Progressive Phenytoin 9.8417484760
MESH:D009207 Myoclonus Fluoxetine 5.088041377
MESH:D009224 Myotonia Congenita Carbamazepine 9.8320399394
MESH:D009224 Myotonia Congenita Phenytoin 9.831896199
MESH:D009336 Necrosis Warfarin 4.7514723717
MESH:D009362 Neoplasm Metastasis irinotecan 4.6118259882
MESH:D009362 Neoplasm Metastasis Tamoxifen 4.6119393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.1819410462
MESH:D009369 Neoplasms Benzo(a)pyrene 5.7411141357
MESH:D009369 Neoplasms pirinixic acid 5.7417405874
MESH:D009369 Neoplasms Thiotepa 5.7418854779
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 3.1919200415 19196722 19189210
MESH:D009402 Nephrosis, Lipoid Cyclosporine 3.6317954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 2.6018481113 19348381
MESH:D009421 Nervous System Malformations Carbamazepine 7.4016990009
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 7.4014600291
MESH:D009436 Neural Tube Defects ochratoxin A 6.2820036863
MESH:D009436 Neural Tube Defects Phenytoin 6.289118846
MESH:D019954 Neurobehavioral Manifestations Plant Extracts 4.4017168769
MESH:D009447 Neuroblastoma irinotecan 6.098761367
MESH:D009447 Neuroblastoma Thiotepa 6.098761367
MESH:D019636 Neurodegenerative Diseases Tacrolimus 4.2815081597
MESH:D017599 Neuroectodermal Tumors irinotecan 9.308761367
MESH:D017599 Neuroectodermal Tumors Thiotepa 9.3012837982 8761367
MESH:D020258 Neurotoxicity Syndromes Chlorpyrifos 6.8515081274
MESH:D020258 Neurotoxicity Syndromes Malathion 6.8515081274
MESH:D009503 Neutropenia Ritonavir 4.6417378895
MESH:D009765 Obesity pirinixic acid 3.8120558911
MESH:D009765 Obesity Plant Extracts 3.8120132043 19056576
MESH:D009771 Obsessive-Compulsive Disorder Fluoxetine 4.7120418887
MESH:D053578 Opsoclonus-Myoclonus Syndrome Trazodone 5.651318289
MESH:D010018 Osteomalacia Carbamazepine 15.7317016548
MESH:D010018 Osteomalacia Phenobarbital 15.7317016548
MESH:D010018 Osteomalacia Phenytoin 15.7317016548
MESH:D015663 Osteoporosis, Postmenopausal Dehydroepiandrosterone 4.2916397352
MESH:D010146 Pain Carbamazepine 14.3315215642
MESH:D010146 Pain Fluoxetine 14.3312798668
MESH:D010146 Pain Lidocaine 14.3315215642
MESH:D010146 Pain Phenytoin 14.3315215642
MESH:D010146 Pain Trazodone 14.3312790215 12798668
MESH:D010190 Pancreatic Neoplasms Etoposide 4.3419003803
MESH:D010190 Pancreatic Neoplasms Phenobarbital 4.3416965848
MESH:D016584 Panic Disorder Ethinyl Estradiol 2.9411578682
MESH:D010212 Papilloma Plant Extracts 3.7216517061 15173996
MESH:D010267 Parapsoriasis Carbamazepine 4.9216538176
MESH:D010302 Parkinson Disease, Secondary Trazodone 4.963378227
OMIM:167400 PAROXYSMAL EXTREME PAIN DISORDER Carbamazepine 5.1217145499 17679678
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 3.4312520081
MESH:D020774 Pick Disease of the Brain Fluoxetine 5.228041377
MESH:D010954 Plasmacytoma Selenium 4.0715087411
MESH:D011041 Poisoning Diazinon 3.6217603234
MESH:D017689 Polydactyly Phenytoin 4.359212184
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 2.8018163543
MESH:D011230 Precancerous Conditions Cyclosporine 6.6812371664
MESH:D011230 Precancerous Conditions Phenobarbital 6.682563599
MESH:D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma Dexamethasone 3.0421297632
MESH:D011248 Pregnancy Complications Carbamazepine 4.379014606
MESH:D011297 Prenatal Exposure Delayed Effects Carbamazepine 7.229014606
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 7.2211222880 11896295 11399792 11118676
MESH:D011470 Prostatic Hyperplasia Calcitriol 3.9815572423
MESH:D019048 Prostatic Intraepithelial Neoplasia Testosterone 4.3320887781
MESH:D011471 Prostatic Neoplasms marker/mechanism 18306354
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.4817292933
MESH:D011471 Prostatic Neoplasms Calcitriol 2.4816289102 15754350 12479363 18247401 16644109
MESH:D011471 Prostatic Neoplasms Cholecalciferol 2.4817024972
MESH:D011471 Prostatic Neoplasms Etoposide 2.4817172428
MESH:D011471 Prostatic Neoplasms gefitinib 2.4817914592 15651060 16685379
MESH:D011471 Prostatic Neoplasms Ketoconazole 2.4817404083
MESH:D011471 Prostatic Neoplasms Plant Extracts 2.4814666653 17804756
MESH:D011471 Prostatic Neoplasms Tamoxifen 2.4815067354
MESH:D011471 Prostatic Neoplasms Vitamin E 2.4815084515
MESH:D020151 Protein C Deficiency Warfarin 5.5518376272
MESH:D011537 Pruritus Ethinyl Estradiol 2.5315861022 16919318
MESH:D019310 Pseudolymphoma Carbamazepine 16.6212752131 9591791
MESH:D019310 Pseudolymphoma Phenobarbital 16.6212752131
MESH:D019310 Pseudolymphoma Phenytoin 16.621419762 8603615 12752131
MESH:D011565 Psoriasis Cyclosporine 1.8816882103
MESH:D011595 Psychomotor Agitation Haloperidol 4.1711575062
MESH:D011618 Psychotic Disorders Haloperidol 3.6411575062
MESH:D011655 Pulmonary Embolism Warfarin 5.5519300499
MESH:D011657 Pulmonary Eosinophilia Trazodone 5.328520792
MESH:D011658 Pulmonary Fibrosis gefitinib 5.3218424623
MESH:D011658 Pulmonary Fibrosis troglitazone 5.3218162602
MESH:D015427 Reperfusion Injury pirinixic acid 1.9319058328
MESH:D012128 Respiratory Distress Syndrome, Adult Dexamethasone 3.2818379247 11700416
MESH:D012131 Respiratory Insufficiency Trazodone 5.028520792
MESH:D012135 Respiratory Sounds Chlorpyrifos 12.0411874814 17119214 16611668
MESH:D012135 Respiratory Sounds Malathion 12.0417119214 11874814
MESH:D012135 Respiratory Sounds Parathion 12.0417119214 11874814
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.0718990726
MESH:D012140 Respiratory Tract Diseases Chlorpyrifos 13.4116611668 17119214
MESH:D012140 Respiratory Tract Diseases Malathion 13.4117119214
MESH:D012140 Respiratory Tract Diseases Parathion 13.4117119214
MESH:D012221 Rhinitis, Allergic, Perennial Terfenadine 5.108201490
MESH:D012509 Sarcoma Ifosfamide 4.9415625365 18313854 17710206
MESH:D012512 Sarcoma, Ewing's Etoposide 3.9414601052
MESH:D012559 Schizophrenia Haloperidol 3.8319369910 18513383 1830565 20107430
MESH:D012559 Schizophrenia Trazodone 3.837868106
MESH:D012640 Seizures Carbamazepine 12.4916938433 9046859 19414003 16876388 15946322 9844417 16180713
MESH:D012640 Seizures Endosulfan 12.4910698677 7539098
MESH:D012640 Seizures Midazolam 12.4910087439
MESH:D012640 Seizures Phenobarbital 12.493137016 16876388 11442880 4039156
MESH:D012640 Seizures Phenytoin 12.4916876388 15946322 3691417 11044598 9844417 3137016 19919933 10029267
MESH:D003294 Seizures, Febrile Phenobarbital 4.026407741
MESH:D020230 Serotonin Syndrome Fluoxetine 10.598704074
MESH:D020230 Serotonin Syndrome Trazodone 10.599050436 8704074 7854515
MESH:D012729 Sex Chromosome Aberrations Chlorpyrifos 5.276418539
MESH:D012735 Sexual Dysfunction, Physiological Testosterone 5.3816631401
MESH:D012851 Sinus Thrombosis, Intracranial Warfarin 5.0912269725
MESH:D012871 Skin Diseases Vitamin E 2.1818709164
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 6.8619755658 10029692
MESH:D012878 Skin Neoplasms Plant Extracts 6.8616517061 15173996
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 6.8616192470
MESH:D012892 Sleep Deprivation Trazodone 5.4519798453
MESH:D012893 Sleep Disorders Carbamazepine 13.7819414003
MESH:D012893 Sleep Disorders Midazolam 13.786138072
MESH:D012893 Sleep Disorders Trazodone 13.7819395429
MESH:D007319 Sleep Initiation and Maintenance Disorders Alprazolam 12.5915341891
MESH:D007319 Sleep Initiation and Maintenance Disorders Midazolam 12.596138071
MESH:D007319 Sleep Initiation and Maintenance Disorders Trazodone 12.5917225163 15341891 15062207
MESH:D012983 Soft Tissue Neoplasms Ifosfamide 5.4415625365
MESH:D013088 Spermatocele Ethinyl Estradiol 8.8616709447
MESH:D013088 Spermatocele Tamoxifen 8.8616709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 3.2419457130
MESH:D013262 Stevens-Johnson Syndrome Carbamazepine 8.9816538176 20485159 19915237 16415921 19694795 18855540 15057820
MESH:D013262 Stevens-Johnson Syndrome Phenytoin 8.9820235791
MESH:D013272 Stomach Diseases Dexamethasone 3.5315472012
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 2.932093021 20155912
MESH:D013274 Stomach Neoplasms irinotecan 2.9315723263
MESH:D013274 Stomach Neoplasms troglitazone 2.9315930296
MESH:D013276 Stomach Ulcer Dexamethasone 5.3415138204
MESH:D013276 Stomach Ulcer Plant Extracts 5.3415255614 17135157 18237397 18193104 12787963
MESH:D020521 Stroke Trazodone 10.97810300
MESH:D020521 Stroke Vitamin E 10.9716517955
MESH:D020521 Stroke Warfarin 10.9719300499
MESH:D013375 Substance Withdrawal Syndrome Trazodone 4.70393279 12749364
MESH:D015173 Supratentorial Neoplasms Thiotepa 5.3712837982
MESH:D017180 Tachycardia, Ventricular Haloperidol 8.5120210726
MESH:D017180 Tachycardia, Ventricular Trazodone 8.512424891
MESH:D013705 Temporomandibular Joint Disorders Plant Extracts 4.6617997062
MESH:D013742 Tetanus Midazolam 5.822903605
MESH:D013923 Thromboembolism Warfarin 5.3518698879 16960144
MESH:D019851 Thrombophilia Ethinyl Estradiol 8.5511994571
MESH:D019851 Thrombophilia Warfarin 8.5517493413
MESH:D013927 Thrombosis Ethinyl Estradiol 7.1315669648
MESH:D013927 Thrombosis Warfarin 7.1315720958 17245631 19300499 11518727 11307788 17672075
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.0912697716
MESH:D013964 Thyroid Neoplasms gefitinib 5.6316940797
MESH:D013964 Thyroid Neoplasms Phenobarbital 5.631399818
MESH:D016171 Torsades de Pointes Terfenadine 4.908256756
MESH:D014376 Tuberculosis Rifampin 4.2218397238 15236969
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 3.7017053015
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 3.7017572228 8653321 16712894
MESH:D014570 Urologic Diseases Diazinon 4.4616487989
MESH:D014581 Urticaria Terfenadine 4.552569995 2565098 2568013 2885854 2859714
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 2.5414692618
MESH:D014605 Uveitis Cyclosporine 9.071336536
MESH:D014605 Uveitis Dexamethasone 9.071336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 3.7812125929
MESH:D014657 Vasculitis Warfarin 5.0920337814
MESH:D054556 Venous Thromboembolism Warfarin 5.5518776969
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 8.3315869587 14671159
MESH:D020246 Venous Thrombosis Warfarin 8.3314723717 15733061
MESH:D018487 Ventricular Dysfunction, Left Plant Extracts 3.9718097624
MESH:D018879 Ventricular Premature Complexes Trazodone 6.012424891
MESH:D020257 Ventricular Remodeling Plant Extracts 4.5218097624
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 3.4315886252
MESH:D014947 Wounds and Injuries Plant Extracts 3.5919894650 20213670
MESH:D014985 Xerophthalmia Cyclosporine 3.6317120751
Pathway ID Pathway Name
REACT:13433 Biological oxidations
KEGG:00982 Drug metabolism - cytochrome P450
KEGG:00983 Drug metabolism - other enzymes
KEGG:00591 Linoleic acid metabolism
KEGG:01100 Metabolic pathways
KEGG:00980 Metabolism of xenobiotics by cytochrome P450
KEGG:00830 Retinol metabolism
KEGG:00140 Steroid hormone biosynthesis
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA131
    • Releated gene ID Related gene Name
    PA124CYP2C19
    PA131CYP3A5
    PA378NR1I2
    Releated disease ID Related disease Name
    PA444760Leukemia, Myeloid, Acute
    PA443560Breast Neoplasms
    PA445062Neoplasms
    PA443937Drug Toxicity
    PA446661Carcinoma, Small Cell
    PA443626Carcinoma, Squamous Cell
    PA444682Kidney Diseases
    PA445113Neutropenia
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    PA444761Leukemia, Myeloid
    PA447178Pulmonary Disease, Chronic Obstructive
    PA134850491Transplantation
    PA446213HIV Infections
    PA444997Muscular Diseases
    PA447216Schizophrenia
    PA446116Inflammatory Bowel Diseases
    PA444552Hypertension
    PA444101Esophageal Neoplasms
    PA447247liver transplantation
    PA151958383Gastrointestinal Stromal Tumors
    PA446171Leukemia, Myelogenous, Chronic, BCR-ABL Positive
    PA446108Colorectal Neoplasms
    PA133888799Organ Transplantation
    PA443265Adenocarcinoma
    PA443557Brain Neoplasms
    PA443756Colonic Neoplasms
    PA444840Lymphoma
    PA444903Melanoma
    PA445204Ovarian Neoplasms
    PA445425Prostatic Neoplasms
    PA447230HIV
    PA443523Blood Coagulation Disorders
    PA445083Nephritis, Interstitial
    PA444447Carcinoma, Hepatocellular
    PA133888799Organ Transplantation
    PA134850491Transplantation
    PA443340Anemia
    PA444773Leukopenia
    PA445846Thrombocytopenia
    PA446975Neurotoxicity Syndromes
    PA445742Stomach Neoplasms
    Releated drug ID Related drug Name
    PA152207466farnesyltransferase inhibitors
    PA165110778Tipifarnib
    PA164713176Platinum compounds
    PA449412doxorubicin
    PA449943hydroxyzine
    PA450704omeprazole
    PA448015acetaminophen
    PA449686fluticasone propionate
    PA450530modafinil
    PA10075esomeprazole
    PA450546montelukast
    PA451257risperidone
    PA451344sibutramine
    PA451866venlafaxine
    PA448383amiodarone
    PA451333sertraline
    PA449035clindamycin
    PA450741oxycodone
    PA451746tretinoin
    PA450344medroxyprogesterone
    PA451201quetiapine
    PA451123progesterone
    PA130232992bevacizumab
    PA128406956fluorouracil
    PA131285527oxaliplatin
    PA164746311everolimus
    PA165260403arteether
    PA165111698artemether
    PA165111696artemisinin
    PA165111697artesunate
    PA450947phenytoin
    PA451753triazolam
    PA450631nifedipine
    PA451627testosterone
    PA448689buspirone
    PA449594fenofibrate
    PA450353meloxicam
    PA449918hydromorphone
    PA449028clarithromycin
    PA451974ziprasidone
    PA451744trazodone
    PA451612terazosin
    PA450128isotretinoin
    PA451976zolpidem
    PA449493erythromycin
    PA162630444eszopiclone
    PA449160cyclobenzaprine
    PA450970pioglitazone
    PA449394donepezil
    PA10074escitalopram
    PA448960chlorpheniramine
    PA449015citalopram
    PA450522mirtazapine
    PA449527ethinyl estradiol
    PA10333tadalafil
    PA448385amitriptyline
    PA449599fentanyl
    PA449900hydrocodone
    PA451346sildenafil
    PA451735tramadol
    PA451142propoxyphene
    PA449283diazepam
    PA451583tamsulosin
    PA448871celecoxib
    PA449841haloperidol
    PA450369meperidine
    PA450266loratadine
    PA450268losartan
    PA448685buprenorphine
    PA451300salmeterol
    PA451668thiotepa
    PA450272lovastatin
    PA449673fluoxetine
    PA448785carbamazepine
    PA448333alprazolam
    PA449688fluvastatin
    PA133950441hmg coa reductase inhibitors
    PA451089pravastatin
    PA134308647rosuvastatin
    PA449383docetaxel
    PA10832corticosteroids
    PA450566mycophenolate mofetil
    PA452609aflatoxin b1
    PA450262loperamide
    PA451627testosterone
    PA164746334cilostazol
    PA448803carboplatin
    PA451581tamoxifen
    PA451213quinine
    PA451899vitamin d and analogues
    PA451611teniposide
    PA130620651anthracyclines and related substances
    PA450401methadone
    PA448388amlodipine
    PA451365sirolimus
    PA452620tegafur
    PA449167cyclosporine
    PA452609aflatoxin b1
    PA451363simvastatin
    PA451868verapamil
    PA131301952gefitinib
    PA449512estrone
    PA450180lansoprazole
    PA450774pantoprazole
    PA451216rabeprazole
    PA450264lopinavir
    PA451260ritonavir
    PA449319digoxin
    PA449653fluconazole
    PA448500atorvastatin
    PA452233antipsychotics
    PA448681budesonide
    PA451305saquinavir
    PA10804imatinib
    PA450761paclitaxel
    PA448492asparaginase
    PA449177cytarabine
    PA449212daunorubicin
    PA449247dexamethasone
    PA449552etoposide
    PA450198leucovorin
    PA450379mercaptopurine
    PA450428methotrexate
    PA451100prednisone
    PA451879vincristine
    PA451578tacrolimus
    PA448084alfentanil
    PA449165cyclophosphamide
    PA452621antineoplastic agents
    PA450085irinotecan
    PA449053clopidogrel
    PA450496midazolam
    PA452604xenobiotics
    PA449011cisapride
    PA449977indinavir
    PA450616nevirapine
    PA452347glucocorticoids
    PA451906warfarin
    PA165290926fluticasone/salmeterol
    PA449334diltiazem
    PA164712468Antimalarials
    PA449167cyclosporine
    PA449957ibuprofen
    Drug Bank Top
    No data
    Drugbank ID Action Drug Name Description
    DB00091 inducer Cyclosporine Antirheumatic Agents;Immunomodulatory Agents;Enzyme Inhibitors;Dermatologic Agents;Immunosuppressive Agents;Antifungal Agents
    DB00175 substrate Pravastatin Anticholesteremic Agents;HMG-CoA Reductase Inhibitors;Hydroxymethylglutaryl-CoA Reductase Inhibitors
    DB00176 inhibitor Fluvoxamine Anti-anxiety Agents;Selective Serotonin Reuptake Inhibitors (SSRIs);Antidepressive Agents;Serotonin Uptake Inhibitors;Antidepressive Agents, Second-Generation
    DB00196 inhibitor Fluconazole Antifungals;Antifungal Agents
    DB00197 inducer Troglitazone Antineoplastic Agents;Hypoglycemic Agents;Vasodilator Agents;Platelet Aggregation Inhibitors;Fibrinolytic Agents
    DB00199 inhibitor T-Stat Pad-Lot Anti-Bacterial Agents;Macrolides
    DB00201 substrate Wigraine Tab Central Nervous System Stimulants;Anorexigenic Agents;Phosphodiesterase Inhibitors
    DB00203 substrate Sildenafil Vasodilator Agents;Phosphodiesterase Inhibitors
    DB00206 inducer SER-AP-ES Tab Antihypertensive Agents;Adrenergic Uptake Inhibitors;Antipsychotics;Peripheral Adrenergic Inhibitors;Antipsychotic Agents
    DB00220 inhibitor Nelfinavir Anti-HIV Agents;HIV Protease Inhibitors
    DB00224 inhibitor Indinavir Anti-HIV Agents;HIV Protease Inhibitors
    DB00227 substrate Lovastatin Antineoplastic Agents;Anticholesteremic Agents;HMG-CoA Reductase Inhibitors;Hydroxymethylglutaryl-CoA Reductase Inhibitors
    DB00238 substrate Nevirapine Anti-HIV Agents;Nonnucleoside Reverse Transcriptase Inhibitors;Reverse Transcriptase Inhibitors
    DB00246 substrate Ziprasidone Antipsychotics;Dopamine Antagonists;Serotonin Antagonists;Antipsychotic Agents
    DB00250 substrate Dapsone Anti-Infective Agents;Anti-Infectives;Anti-inflammatory Agents;Antimalarials;Folic Acid Antagonists;Leprostatic Agents;Antimycobacterials
    DB00252 inducer Dilantin W Phenobarbital 30mg Cap Anticonvulsants
    DB00278 substrate Argatroban Anticoagulants;Platelet Aggregation Inhibitors
    DB00281 substrate Xylonor Spray Antiarrhythmic Agents;Anesthetics;Anesthetics, Local;Anti-Arrhythmia Agents
    DB00313 substrate Valproic Acid Anticonvulsants;Enzyme Inhibitors;Antimanic Agents;GABA Agents
    DB00318 substrate Co-codamol Narcotics;Analgesics;Opiate Agonists;Antitussives;Analgesics, Opioid;Antitussive Agents
    DB00321 substrate Triavil Tab Adrenergic Uptake Inhibitors;Analgesics, Non-Narcotic;Antidepressive Agents, Tricyclic
    DB00333 substrate Methadone Narcotics;Analgesics;Opiate Agonists;Antitussives;Analgesics, Opioid;Antitussive Agents
    DB00342 substrate Terfenadine Antiarrhythmic Agents;Anti-Allergic Agents;Antihistamines;Histamine H1 Antagonists, Non-Sedating
    DB00343 inhibitor Diltiazem Antihypertensive Agents;Vasodilator Agents;Calcium Channel Blockers;Cardiovascular Agents
    DB00381 substrate Lotrel Antihypertensive Agents;Vasodilator Agents;Calcium Channel Blockers;Antianginals
    DB00393 substrate Nimodipine Antihypertensive Agents;Vasodilator Agents;Calcium Channel Blockers
    DB00394 inducer Beclomethasone Anti-Asthmatic Agents;Anti-inflammatory Agents;Antiarrhythmic Agents;Corticosteroids;Glucocorticoids
    DB00396 substrate Synovex S Contraceptives;Progestins
    DB00398 substrate Sorafenib Antineoplastic Agents;Protein Kinase Inhibitors;Anticancer Agents
    DB00401 substrate Nisoldipine Antihypertensive Agents;Vasodilator Agents;Calcium Channel Blockers
    DB00404 substrate Alprazolam Anti-anxiety Agents;Hypnotics and Sedatives;Benzodiazepines;GABA Modulators
    DB00425 substrate Zolpidem GABA Agonists;Hypnotics and Sedatives
    DB00439 substrate Cerivastatin Anticholesteremic Agents;Antilipemic Agents;Hydroxymethylglutaryl-CoA Reductase Inhibitors
    DB00444 substrate Teniposide Antineoplastic Agents;Enzyme Inhibitors;Nucleic Acid Synthesis Inhibitors
    DB00446 inhibitor Zoomycetine Spray Anti-Bacterial Agents;Protein Synthesis Inhibitors
    DB00468 substrate Triogene for Antimalarials;Analgesics, Non-Narcotic;Muscle Relaxants, Central
    DB00490 substrate Buspirone Anti-anxiety Agents;Serotonin Agonists;Anxiolytics sedatives and hypnotics
    DB00497 substrate Tylox Narcotics;Opiate Agonists;Antitussives;Analgesics, Opioid
    DB00499 substrate Flutamide Antineoplastic Agents, Hormonal;Androgen Antagonists
    DB00501 inhibitor Cimetidine Anti-Ulcer Agents;Analgesics;Enzyme Inhibitors;Adjuvants;Histamine Antagonists;Histamine H2 Antagonists
    DB00502 substrate Haloperidol Antiemetics;Antidyskinetics;Antipsychotics;Dopamine Antagonists;Antipsychotic Agents;Butyrophenones;Anti-Dyskinesia Agents
    DB00503 inhibitor Kaletra Anti-HIV Agents;HIV Protease Inhibitors
    DB00514 substrate Tussin Cough Medicine Dm Antitussive Expectorant Decongestant Analgesics, Opioid;Antitussive Agents;Excitatory Amino Acid Antagonists
    DB00528 substrate Lercanidipine Antihypertensive Agents;Calcium Channel Blockers
    DB00530 substrate Erlotinib Protein Kinase Inhibitors
    DB00532 - Mephenytoin Anticonvulsants
    DB00537 inhibitor Ciprodex Anti-Infective Agents;Anti-Infectives;Quinolones;Nucleic Acid Synthesis Inhibitors
    DB00540 substrate Nortriptyline Antidepressants;Adrenergic Uptake Inhibitors;Antidepressive Agents, Tricyclic;Norepinephrine-Reuptake Inhibitors
    DB00541 substrate Vincristine Antineoplastic Agents;Antineoplastic Agents, Phytogenic;Tubulin Modulators
    DB00564 inducer Carbamazepine Anticonvulsants;Analgesics;Antimanic Agents;Analgesics, Non-Narcotic
    DB00571 substrate Propranolol Anti-anxiety Agents;Antihypertensive Agents;Adrenergic Agents;Adrenergic beta-Antagonists;Vasodilator Agents;Antiarrhythmic Agents;Anti-Arrhythmia Agents
    DB00582 inhibitor Voriconazole Antifungals;Antifungal Agents
    DB00588 inhibitor Fluticasone Propionate Anti-inflammatory Agents;Adrenergic Agents;Dermatologic Agents;Bronchodilator Agents;Anti-Allergic Agents
    DB00593 substrate Ethosuximide Anticonvulsants;Succinimides
    DB00604 substrate Cisapride Anti-Ulcer Agents;Gastrointestinal Agents;Serotonin Agonists;Prokinetic Agents
    DB00608 substrate Chloroquine Antirheumatic Agents;Antimalarials;Amebicides
    DB00619 inhibitor Imatinib Antineoplastic Agents;Protein Kinase Inhibitors
    DB00622 inhibitor Nicardipine Antihypertensive Agents;Vasodilator Agents;Antiarrhythmic Agents;Calcium Channel Blockers;Dihydropyridines
    DB00624 substrate Uni-Bol Androgens
    DB00637 substrate Astemizole Anti-Allergic Agents;Antihistamines;Histamine H1 Antagonists, Non-Sedating
    DB00641 substrate Vytorin Anticholesteremic Agents;Antilipemic Agents;Hydroxymethylglutaryl-CoA Reductase Inhibitors
    DB00655 substrate Holis 98 Antineoplastic Agents;Estrogens;Osteoporosis Prophylactic;Anti-menopausal Agents
    DB00656 substrate Trazodone Anti-anxiety Agents;Antidepressants, Second-Generation;Serotonin Uptake Inhibitors;Antidepressive Agents, Second-Generation
    DB00661 inhibitor Tarka Vasodilator Agents;Antiarrhythmic Agents;Calcium Channel Blockers;Anti-Arrhythmia Agents
    DB00673 inhibitor Aprepitant Antiemetics
    DB00675 substrate Tamoxifen Antineoplastic Agents, Hormonal;Selective Estrogen Receptor Modulators;Estrogen Antagonists;Bone Density Conservation Agents
    DB00678 substrate Hyzaar Antihypertensive Agents;Angiotensin II Receptor Antagonists;Antiarrhythmic Agents;Angiotensin II Type 1 Receptor Blockers;Anti-Arrhythmia Agents
    DB00683 substrate Midazolam Anti-anxiety Agents;Hypnotics and Sedatives;Adjuvants, Anesthesia;GABA Modulators;Anesthetics, Intravenous
    DB00694 - Daunorubicin Antineoplastic Agents;Antibiotics;Antibiotics, Antineoplastic
    DB00700 substrate Eplerenone Antihypertensive Agents;Aldosterone Antagonists
    DB00701 substrate Amprenavir Anti-HIV Agents;HIV Protease Inhibitors;Antibiotics, Antitubercular
    DB00705 inhibitor Delavirdine Anti-HIV Agents;Nonnucleoside Reverse Transcriptase Inhibitors;Reverse Transcriptase Inhibitors
    DB00717 substrate Synphasic (28 day) Contraceptives, Oral, Synthetic;Progestins
    DB00731 substrate Nateglinide Hypoglycemic Agents;Meglitinides
    DB00734 substrate Risperidone Antipsychotics;Dopamine Antagonists;Serotonin Antagonists;Antipsychotic Agents
    DB00738 substrate Pentamidine Antifungal Agents;Trypanocidal Agents;Antiprotozoal Agents
    DB00741 substrate Vosol Hc Anti-inflammatory Agents
    DB00745 inducer Modafinil Central Nervous System Stimulants;Central Nervous System Agents;Anorexigenic Agents;Stimulants;Neuroprotective Agents
    DB00755 substrate Tretinoin Antineoplastic Agents;Keratolytic Agents;Cell Stimulants and Proliferants
    DB00758 substrate Clopidogrel Antiplatelet Agents;Platelet Aggregation Inhibitors;Fibrinolytic Agents
    DB00762 substrate Irinotecan Antineoplastic Agents;Radiation-Sensitizing Agents;Parasympathomimetics;Enzyme Inhibitors;Prodrugs;Antineoplastic Agents, Phytogenic
    DB00773 inducer Etoposide Nucleic Acid Synthesis Inhibitors;Antineoplastic Agents, Phytogenic
    DB00776 inducer Oxcarbazepine Anticonvulsants
    DB00780 inhibitor Phenelzine Antidepressants;Antidepressive Agents;Monoamine Oxidase Inhibitors
    DB00783 substrate Triquilar 21 Anticholesteremic Agents;Estrogens;Anti-menopausal Agents
    DB00795 substrate Sulfasalazine Antirheumatic Agents;Anti-Infective Agents;Sulfonamides;Gastrointestinal Agents
    DB00802 substrate Alfentanil Narcotics;Analgesics;Anesthetics;Anesthetics, Intravenous;Opiate Agonists;Analgesics, Opioid
    DB00813 substrate Innovar Injection Narcotics;Analgesics;Adjuvants, Anesthesia;Anesthetics;Anesthetics, Intravenous;Opiate Agonists;Analgesics, Opioid;Adjuvants
    DB00822 substrate Disulfiram Enzyme Inhibitors;Alcohol Deterrents
    DB00829 substrate Diazepam Anti-anxiety Agents;Hypnotics and Sedatives;Antiemetics;Anticonvulsants;Adjuvants, Anesthesia;GABA Modulators;Anesthetics, Intravenous;Muscle Relaxants, Central
    DB00834 inhibitor Mifepristone Contraceptives, Oral, Synthetic;Menstruation-Inducing Agents;Luteolytic Agents;Contraceptives, Postcoital, Synthetic;Hormone Antagonists;Abortifacient Agents, Steroidal
    DB00842 substrate Oxazepam Anti-anxiety Agents;Hypnotics and Sedatives;GABA Modulators
    DB00862 substrate Vardenafil Vasoconstrictor Agents;Phosphodiesterase Inhibitors;Anti-Impotence Agents
    DB00863 inhibitor Tritec Anti-Ulcer Agents;Histamine H2 Antagonists
    DB00864 substrate Tacrolimus Immunosuppressive Agents
    DB00877 substrate Sirolimus Anti-Bacterial Agents;Antifungals;Immunosuppressive Agents;Antifungal Agents;Antibiotics, Antineoplastic;Macrolides
    DB00889 substrate Granisetron Antiemetics;Serotonin Antagonists
    DB00897 substrate Triazolam Anti-anxiety Agents;Benzodiazepines;Adjuvants, Anesthesia;GABA Modulators
    DB00904 substrate Ondansetron Anti-anxiety Agents;Antiemetics;Antipsychotics;Serotonin Antagonists;Antipruritics;Antipsychotic Agents
    DB00907 substrate Cocaine Vasoconstrictor Agents;Dopamine Uptake Inhibitors;Anesthetics;Local Anesthetics;Anesthetics, Local
    DB00921 substrate Buprenorphine Narcotics;Analgesics, Opioid;Narcotic Antagonists
    DB00938 substrate Advair 500 Diskus Bronchodilator Agents;Adrenergic beta-Agonists;Sympathomimetic
    DB00943 substrate Zalcitabine Anti-HIV Agents;Antimetabolites;Nucleoside and Nucleotide Reverse Transcriptase Inhibitors;Reverse Transcriptase Inhibitors
    DB00962 substrate Zaleplon Hypnotics and Sedatives;Anticonvulsants;Anxiolytics sedatives and hypnotics
    DB00972 substrate Azelastine Lipoxygenase Inhibitors;Platelet Aggregation Inhibitors;Bronchodilator Agents;Anti-Allergic Agents;Histamine H1 Antagonists;Histamine H1 Antagonists, Non-Sedating
    DB00976 inhibitor Telithromycin Anti-Bacterial Agents;Ketolides
    DB01023 substrate Lexxel Antihypertensive Agents;Vasodilator Agents;Calcium Channel Blockers;Dihydropyridines
    DB01026 inhibitor Ketoconazole Antifungals;Antifungal Agents
    DB01041 inducer Thalidomide Immunosuppressive Agents;Leprostatic Agents;Teratogens;Angiogenesis Inhibitors
    DB01045 inducer Rifater Enzyme Inhibitors;Antituberculosis Agents;Nucleic Acid Synthesis Inhibitors;Leprostatic Agents;Antibiotics;Antibiotics, Antitubercular
    DB01054 substrate Nitrendipine Antihypertensive Agents;Vasodilator Agents;Calcium Channel Blockers
    DB01058 substrate Drontal Tab Anthelmintics
    DB01059 inhibitor Norfloxacin Anti-Infectives;Anti-Bacterial Agents;Enzyme Inhibitors;Quinolones;Nucleic Acid Synthesis Inhibitors
    DB01062 substrate Oxybutynin Muscarinic Antagonists;Antispasmodics;Anticholinergic Agents;Parasympatholytics;Genitourinary Smooth Muscle Relaxants
    DB01076 substrate Caduet Anticholesteremic Agents;HMG-CoA Reductase Inhibitors;Hydroxymethylglutaryl-CoA Reductase Inhibitors
    DB01098 inhibitor Rosuvastatin Anticholesteremic Agents;HMG-CoA Reductase Inhibitors;Hydroxymethylglutaryl-CoA Reductase Inhibitors
    DB01100 substrate Pimozide Dopamine Antagonists;Antipsychotic Agents;Anti-Dyskinesia Agents
    DB01103 substrate Quinacrine Antineoplastic Agents;Enzyme Inhibitors;Antiprotozoals;Antimalarials;Anticestodal Agents;Antinematodal Agents;Antihelmintics
    DB01114 substrate Triaminicol Dm Syrup Antipruritics;Anti-Allergic Agents;Histamine H1 Antagonists;Antihistamines
    DB01115 substrate Nifedipine Vasodilator Agents;Calcium Channel Blockers;Tocolytic Agents;Dihydropyridines
    DB01118 inhibitor Amiodarone Vasodilator Agents;Enzyme Inhibitors;Anti-Arrhythmia Agents
    DB01126 substrate Dutasteride Enzyme Inhibitors;Anti-baldness Agents;Antihyperplasia Agents
    DB01149 inhibitor Nefazodone Antidepressants;Analgesics;Antidepressive Agents, Second-Generation;Serotonin Agents
    DB01166 substrate Cilostazol Vasodilator Agents;Platelet Aggregation Inhibitors;Fibrinolytic Agents;Phosphodiesterase Inhibitors;Bronchodilator Agents;Neuroprotective Agents
    DB01167 inhibitor Itraconazole Antifungals;Antiprotozoals;Antifungal Agents;Antiprotozoal Agents
    DB01174 inducer Phenobarbital Hypnotics and Sedatives;Anticonvulsants;GABA Modulators;Excitatory Amino Acid Antagonists
    DB01181 substrate Ifosfamide Antineoplastic Agents;Immunosuppressive Agents;Antineoplastic Agents, Alkylating
    DB01184 substrate Domperidone Antiemetics;Dopamine Antagonists
    DB01201 inducer Rifapentine Leprostatic Agents;Antimycobacterials;Antibiotics, Antitubercular
    DB01211 inhibitor Clarithromycin Anti-Bacterial Agents;Other Macrolides;Protein Synthesis Inhibitors;Macrolides
    DB01216 substrate Finasteride Enzyme Inhibitors;Skin and Mucous Membrane Agents;Anti-baldness Agents;Antihyperplasia Agents
    DB01218 substrate Halofantrine Antiprotozoals;Antimalarials
    DB01224 substrate Quetiapine Antipsychotics;Antipsychotic Agents
    DB01227 substrate Levomethadyl Acetate Narcotics;Analgesics, Opioid
    DB01229 substrate Paclitaxel Antineoplastic Agents;Antineoplastic Agents, Phytogenic;Tubulin Modulators
    DB01232 inhibitor Saquinavir Anti-HIV Agents;HIV Protease Inhibitors
    DB01234 inducer Tresaderm Dermatologic Solution Anti-inflammatory Agents;Adrenergic Agents;Antiemetics;Antineoplastic Agents, Hormonal;Glucocorticoids
    DB01238 substrate Aripiprazole Antipsychotics;Antipsychotic Agents
    DB01248 substrate Docetaxel Antineoplastic Agents;Radiation-Sensitizing Agents;Antimalarials;Antineoplastic Agents, Phytogenic
    DB01254 substrate Dasatinib Protein Kinase Inhibitors
    DB01259 substrate Lapatinib Antineoplastic Agents;Protein Kinase Inhibitors
    DB01268 substrate Sunitinib Antineoplastic Agents;Angiogenesis Inhibitors
    DB01361 - Troleandomycin Anti-Bacterial Agents;Antibacterial Agents;Macrolides
    DB01388 inhibitor Mibefradil Antihypertensive Agents;Vasodilator Agents;Calcium Channel Blockers
    DB06267 substrate Udenafil Vasodilator Agents;Phosphodiesterase Inhibitors
    DB06287 inhibitor Temsirolimus Antineoplastic Agents;Protein Kinase Inhibitors
    DB06335 substrate Saxagliptin
    DB06697 substrate Riamet Antimalarials;Antiprotozoal Agents;Antimalarial Agents
    DB06730 inhibitor Gestodene
    DB06731 inhibitor Seproxetine
    DB06772 substrate Cabazitaxel Antineoplastic Agents;Anticancer Agents
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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