AutismKB 2.0

Annotation Detail for TDH


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Basic Information Top
Gene Symbol:TDH ( FLJ25033,SDR14E1P )
Gene Full Name: L-threonine dehydrogenase
Band: 8p23.1
Quick LinksEntrez ID:157739; OMIM: NA; Uniprot ID:; ENSEMBL ID: ; HGNC ID: 15547
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in increased expression of TDH mRNAincreases expression 18648102
D004997 Ethinyl Estradiol Ethinyl Estradiol results in decreased expression of TDH mRNAdecreases expression 17475347
D008767 Methylmercury Compounds Methylmercury Compounds results in decreased expression of TDH mRNAdecreases expression 16966085
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.8117505938
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.8914692618
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 2.983712494
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 4.1211256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.9115885639
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.891440618 11289319
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 1.783581430 7296757
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.847296757
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 3.057505956
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 8.969022650 19486331
MESH:D002779 Cholestasis Ethinyl Estradiol 8.9615861022 16919318 17110522 17681005 17333356 16105132 11677210
MESH:D003704 Dementia Methylmercury Compounds 5.4816140633
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 3.4411298694 18759878 14531868 8156756 11906362 2524372 12868966 8970840
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 4.022952479 3621924
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 2.056482804 8291058 18289764 6679447 18692083 9653073 11289319 18648102 7440962 16192314 9328219 1440618 9022650
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.7712538720
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 2.193581430
MESH:D005234 Fatty Liver Ethinyl Estradiol 3.2915345470
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.896705139
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.577505956
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 4.106705139
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.5915034207
MESH:D007021 Hypospadias Ethinyl Estradiol 4.4616945680 16569931
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.9912013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.7617937319
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.899022650 8074119
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 3.356582329
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.4415034207 9327722
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 2.78598648 6587162 1399818 3712494
MESH:D008569 Memory Disorders Methylmercury Compounds 5.4918436314
MESH:D009069 Movement Disorders Methylmercury Compounds 5.8518436314
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 2.613581430
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 3.186679447
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 3.876482804 4026338
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.893988306
MESH:D016584 Panic Disorder Ethinyl Estradiol 4.2211578682
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 4.137296757
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 5.346228378
MESH:D011297 Prenatal Exposure Delayed Effects Methylmercury Compounds 5.7218436314
MESH:D011537 Pruritus Ethinyl Estradiol 4.0516919318 15861022
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.703692021
MESH:D013088 Spermatocele Ethinyl Estradiol 4.8116709447
MESH:D019851 Thrombophilia Ethinyl Estradiol 4.1511994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.5715669648
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 3.221399818 7505956 6587162 3712494 6582329
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 2.418074119
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.8814692618
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 4.0215869587 14671159
Pathway ID Pathway Name
KEGG:00260 Glycine, serine and threonine metabolism
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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