AutismKB 2.0

Annotation Detail for CYP4B1


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Basic Information Top
Gene Symbol:CYP4B1 ( CYPIVB1,P-450HP )
Gene Full Name: cytochrome P450, family 4, subfamily B, polypeptide 1
Band: 1p33
Quick LinksEntrez ID:1580; OMIM: 124075; Uniprot ID:CP4B1_HUMAN; ENSEMBL ID: ENSG00000142973; HGNC ID: 2644
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
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Pathway IDPathway Name
Biological oxidations
No data
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Pathway IDPathway Name
500200Fatty acids
Related Diseases/Disorders Top
No data
No data
Desease Name
CARDIOVASCULAR
hypertension
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C001042 2',3-dimethyl-4-aminobiphenyl CYP4B1 protein results in increased metabolism of 2',3-dimethyl-4-aminobiphenylincreases metabolic processing 9310344
C012177 2-aminofluorene CYP4B1 protein results in increased metabolism of 2-aminofluoreneincreases metabolic processing 18713828
C093383 3-methylbenzaldehyde 3-methylbenzaldehyde affects the activity of CYP4B1 proteinaffects activity 12791539
C042289 3-methylbenzyl alcohol 3-methylbenzyl alcohol results in decreased activity of CYP4B1 proteindecreases activity 12791539
C031285 3-xylene 3-xylene affects the activity of CYP4B1 proteinaffects activity 15204773
C031285 3-xylene 3-xylene results in decreased activity of CYP4B1 proteindecreases activity 8598570
12791539
C001470 4-ipomeanol CYP4B1 protein results in increased activity of 4-ipomeanolincreases activity 15892579
C001470 4-ipomeanol CYP4B1 protein affects the metabolism of 4-ipomeanolaffects metabolic processing 8248926
C001470 4-ipomeanol CYP4B1 protein results in increased susceptibility to 4-ipomeanolincreases response to substance 8248926
D000082 Acetaminophen Acetaminophen affects the expression of CYP4B1 mRNAaffects expression 17562736
D015081 2-Naphthylamine CYP4B1 protein results in increased metabolism of 2-Naphthylamineincreases metabolic processing 9310344
D015081 2-Naphthylamine CYP4B1 protein results in increased metabolism of 2-Naphthylamineincreases metabolic processing 9310344
D015081 2-Naphthylamine CYP4B1 protein results in increased metabolism of 2-Naphthylamineincreases metabolic processing 18713828
D000643 Ammonium Chloride Ammonium Chloride affects the expression of CYP4B1 mRNAaffects expression 16483693
C029876 benzidine CYP4B1 protein results in increased metabolism of benzidineincreases metabolic processing 18713828
D019324 beta-Naphthoflavone beta-Naphthoflavone results in decreased expression of CYP4B1 mRNAdecreases expression 16985168
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of CYP4B1 mRNAdecreases expression 20106945
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of CYP4B1 mRNAaffects expression 16239168
D016572 Cyclosporine Cyclosporine results in decreased expression of CYP4B1 mRNAdecreases expression 20106945
D015101 3,3'-Dichlorobenzidine CYP4B1 protein results in increased metabolism of 3,3'-Dichlorobenzidineincreases metabolic processing 9310344
D015101 3,3'-Dichlorobenzidine lauric acid inhibits the reaction [CYP4B1 protein results in increased metabolism of 3,3'-Dichlorobenzidine]decreases reaction|increases metabolic processing 9310344
D015101 3,3'-Dichlorobenzidine CYP4B1 protein results in increased metabolism of 3,3'-Dichlorobenzidineincreases metabolic processing 9310344
D004041 Dietary Fats Dietary Fats results in decreased expression of CYP4B1 mRNAdecreases expression 18042831
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with kojic acid] results in decreased expression of CYP4B1 mRNAaffects cotreatment|decreases expression 17917374
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of CYP4B1 mRNAaffects cotreatment|decreases expression 18544905
D004052 Diethylnitrosamine [Fenofibrate co-treated with Diethylnitrosamine] results in decreased expression of CYP4B1 mRNAaffects cotreatment|decreases expression 18253720
D004052 Diethylnitrosamine [gum mastic co-treated with Diethylnitrosamine] results in decreased expression of CYP4B1 mRNAaffects cotreatment|decreases expression 18977376
D004958 Estradiol [Progesterone co-treated with Estradiol] results in increased expression of CYP4B1 mRNAaffects cotreatment|increases expression 17404688
D004958 Estradiol Estradiol results in decreased expression of CYP4B1 mRNAdecreases expression 14664709
D000431 Ethanol Ethanol results in decreased expression of CYP4B1 mRNAdecreases expression 15353170
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of CYP4B1 mRNAaffects expression 17555576
D004997 Ethinyl Estradiol Ethinyl Estradiol results in decreased expression of CYP4B1 mRNAdecreases expression 16174780
17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in decreased expression of CYP4B1 mRNAaffects cotreatment|decreases expression 17942748
D004997 Ethinyl Estradiol Ethinyl Estradiol results in decreased expression of CYP4B1 mRNAdecreases expression 16174780
17351261
D011345 Fenofibrate [Fenofibrate co-treated with Diethylnitrosamine] results in decreased expression of CYP4B1 mRNAaffects cotreatment|decreases expression 18253720
D005419 Flavonoids Flavonoids results in decreased expression of CYP4B1 mRNAdecreases expression 18035473
C071834 glycidamide glycidamide results in decreased expression of CYP4B1 mRNAdecreases expression 17822822
C043285 gum mastic [gum mastic co-treated with Diethylnitrosamine] results in decreased expression of CYP4B1 mRNAaffects cotreatment|decreases expression 18977376
C011890 kojic acid [Diethylnitrosamine co-treated with kojic acid] results in decreased expression of CYP4B1 mRNAaffects cotreatment|decreases expression 17917374
C011890 kojic acid [Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of CYP4B1 mRNAaffects cotreatment|decreases expression 18544905
C030358 lauric acid lauric acid inhibits the reaction [CYP4B1 protein results in increased metabolism of 3,3'-Dichlorobenzidine]decreases reaction|increases metabolic processing 9310344
D015735 Mifepristone Mifepristone results in decreased expression of CYP4B1 mRNAdecreases expression 17584828
D010126 Ozone Ozone results in decreased expression of CYP4B1 mRNAdecreases expression 16183385
C041786 palm oil palm oil results in decreased expression of CYP4B1 mRNAdecreases expression 18042831
C023036 perfluorooctanoic acid perfluorooctanoic acid results in increased expression of CYP4B1 mRNAincreases expression 16221955
D010634 Phenobarbital Phenobarbital results in increased expression of CYP4B1 mRNAincreases expression 12082028
C006253 pirinixic acid pirinixic acid results in decreased expression of CYP4B1 mRNAdecreases expression 18467677
C006253 pirinixic acid pirinixic acid results in increased expression of CYP4B1 mRNAincreases expression 17426115
C006253 pirinixic acid PPARA protein promotes the reaction [pirinixic acid results in decreased expression of CYP4B1 mRNA]decreases expression|increases reaction 18467677
D011285 Pregnenolone Carbonitrile Pregnenolone Carbonitrile results in decreased expression of CYP4B1 mRNAdecreases expression 15596064
D011374 Progesterone [Progesterone co-treated with Estradiol] results in increased expression of CYP4B1 mRNAaffects cotreatment|increases expression 17404688
D011374 Progesterone Progesterone results in increased expression of CYP4B1 mRNAincreases expression 17404688
D012643 Selenium Selenium deficiency results in increased expression of CYP4B1 mRNAincreases expression 11444866
D013629 Tamoxifen Tamoxifen affects the expression of CYP4B1 mRNAaffects expression 17555576
C011363 terephthalic acid terephthalic acid results in increased expression of CYP4B1 mRNAincreases expression 16673812
D013739 Testosterone Testosterone results in increased expression of CYP4B1 mRNAincreases expression 11311483
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of CYP4B1 mRNAdecreases expression 20106945
16985168
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in decreased expression of CYP4B1 mRNAaffects cotreatment|decreases expression 17942748
D014050 Toluene Toluene affects the expression of CYP4B1 mRNAaffects expression 18653662
D014212 Tretinoin Tretinoin results in decreased expression of CYP4B1 mRNAdecreases expression 16985168
D014212 Tretinoin Tretinoin results in increased expression of CYP4B1 mRNAincreases expression 16249480
C025643 vinclozolin vinclozolin affects the expression of CYP4B1 mRNAaffects expression 19015723
D015032 Zinc Zinc results in increased expression of CYP4B1 mRNAincreases expression 17074742
D019287 Zinc Sulfate Zinc Sulfate results in increased expression of CYP4B1 mRNAincreases expression 17074742
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.0714745880
MESH:D000014 Abnormalities, Drug-Induced Ethanol 11.5718926900 17676605
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 11.576195326
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 11.5715322242 11752688 14514962
MESH:D000138 Acidosis Ammonium Chloride 15.1618287403
MESH:D000138 Acidosis Ethanol 15.1611192467
MESH:D000138 Acidosis Zinc Sulfate 15.167265320
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.4717505938
MESH:D000169 Acrodermatitis Zinc 4.9416889938 17190629 17202136
MESH:D055371 Acute Lung Injury 3-xylene 8.0915204773
MESH:D055371 Acute Lung Injury pirinixic acid 8.0918653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 6.1820127859 20464547
MESH:D000230 Adenocarcinoma Estradiol 6.1811473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 6.1814692618
MESH:D000236 Adenoma Benzo(a)pyrene 9.576695378
MESH:D000236 Adenoma beta-Naphthoflavone 9.5719389873
MESH:D000236 Adenoma Diethylnitrosamine 9.5710737359 6695378
MESH:D018248 Adenoma, Liver Cell 2-aminofluorene 27.7519052882
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 27.7516434500 17620307 19061943 17162532 18056438 19052882
MESH:D018248 Adenoma, Liver Cell Phenobarbital 27.7517620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 27.7516434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 27.7516835633
MESH:D020268 Alcohol-Induced Disorders, Nervous System Ethanol 4.8415451040 15451039
MESH:D000505 Alopecia Tretinoin 3.2515955085
MESH:D000544 Alzheimer Disease Ozone 4.0315513908
MESH:D000544 Alzheimer Disease Zinc 4.0317119284 16325427 16580781 16410023
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.5511748828
MESH:D000755 Anemia, Sickle Cell Zinc 4.4616916123
MESH:D000799 Angioedema Acetaminophen 3.3710982225
MESH:D000853 Anophthalmos Ethanol 4.3715513904
MESH:D000860 Anoxia Zinc Sulfate 4.557265320
MESH:D000987 Antisocial Personality Disorder Testosterone 5.387506515
MESH:D001008 Anxiety Disorders Ethanol 7.7911141031
MESH:D001008 Anxiety Disorders vinclozolin 7.7919015723
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 3.6219183758
MESH:D001161 Arteriosclerosis Dietary Fats 8.4015238619
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 8.4011256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 6.2215885639
MESH:D001169 Arthritis, Experimental Tretinoin 6.2216412693
MESH:D001172 Arthritis, Rheumatoid Ozone 4.2315570426
MESH:D001172 Arthritis, Rheumatoid Tretinoin 4.2316292516
MESH:D001249 Asthma Ozone 7.0216373670 17854713
MESH:D001249 Asthma Tretinoin 7.0216456186
MESH:D001249 Asthma Zinc 7.0217085522
MESH:D001321 Autistic Disorder Acetaminophen 1.4718445737
MESH:D001471 Barrett Esophagus Tretinoin 3.9616935849
MESH:D001778 Blood Coagulation Disorders pirinixic acid 12.8619483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 12.8612125929
MESH:D001778 Blood Coagulation Disorders Tretinoin 12.8616206674 16197459
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.3215340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.4615746008
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 4.8617868700
MESH:D001930 Brain Injuries Progesterone 9.5315380490 15665606 15845082
MESH:D001930 Brain Injuries Zinc 9.5317109824
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 5.2620146248 17474063
MESH:D001943 Breast Neoplasms Dietary Fats 5.2620435547
MESH:D001943 Breast Neoplasms Diethylnitrosamine 5.2617474063
MESH:D001943 Breast Neoplasms Estradiol 5.2616675129 12948864 17261762 14630087 17018787 17289903 19861407 18497071
MESH:D001943 Breast Neoplasms Progesterone 5.2617614352 15562024 16175315
MESH:D001943 Breast Neoplasms Tamoxifen 5.2611161223 16873071 18855134 19244106 20135344 19059307 19115204 17049068 15668708 19066611 18629630 17261762 19155303 18821012 19011961 16202921 19084267 18425577 19288272 20005174 20544844 19410462 17893378 17242785 18815881 19200415 15565566 19289846 20390343 21152245 19189212 17440819 19189210 16818667 20859285 18984771 19221464 21138602 19103187 18997820 19142967 18351453 20065188 19487384 16273361
MESH:D001943 Breast Neoplasms Testosterone 5.2617261762
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 5.2620435547
MESH:D001943 Breast Neoplasms Tretinoin 5.2616443354 16166294 16873071
MESH:D016535 Bronchial Hyperreactivity Ozone 3.3117626835 15516495 14754758 18315731 19059883 16777450 18417511
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.1216813970
MESH:D002056 Burns Ethanol 4.2016374292
MESH:D002100 Cachexia Ozone 4.2716183385
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.0016111702
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.3316192424 15673190 16050911 15721981 10355542 15700767 16097048 16227642 16124888 16011737 3786805 18705752
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.4316835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.0519066611
MESH:D018236 Carcinoma, Embryonal Tretinoin 4.6816168501
MESH:D006528 Carcinoma, Hepatocellular 2-aminofluorene 18.0319052882
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 18.033084413
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 18.0318788625
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 18.0311831363 3084413 20432363 17978847 18494052 17761372 16779866 16878318 17428255 19394651 18056438 18785209 18691550 18788625 16681979 18506893 17162532 19171122 18665156 20514400 20524982 18210153 20101231 19539802 10737359 10672840 19383236 17173139 19107877 3581430 19418558 17055752 19822196 17138121 20007298 16502159 18971187 19335982 21159647 19052882 18978308 18393292 20512989 16328049 16935385 19919837 19208518 16807293 16830150 20084675 16698587 20935162 20214788 19519916 20727157 19701751 16540662 16288022 16569478
MESH:D006528 Carcinoma, Hepatocellular Estradiol 18.0316924424
MESH:D006528 Carcinoma, Hepatocellular Ethanol 18.0315289165 15763234 18788625
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 18.036705139 20935162 20007298 17173139 1701930
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 18.0316924424
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 18.031917145
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 6.6620419170
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 6.6616096774 16051514
MESH:D002294 Carcinoma, Squamous Cell Zinc 6.6616543248
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.2117572228
MESH:D006332 Cardiomegaly Ethanol 5.9419332462
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 5.9418850075 18670907 16120746
MESH:D002318 Cardiovascular Diseases Zinc 3.3416936243
MESH:D002386 Cataract Acetaminophen 6.2810977129
MESH:D002386 Cataract Tretinoin 6.2817460283
MESH:D002471 Cell Transformation, Neoplastic 2',3-dimethyl-4-aminobiphenyl 13.451399818
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 13.4512371664
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 13.4517174075 21159647 7505956 2727394
MESH:D002471 Cell Transformation, Neoplastic Estradiol 13.4518566989
MESH:D002493 Central Nervous System Diseases Phenobarbital 3.804080065
MESH:D002547 Cerebral Palsy Toluene 5.389294310
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.1216129372
MESH:D002659 Child Development Disorders, Pervasive Testosterone 3.4920678186
MESH:D018281 Cholangiocarcinoma 2-aminofluorene 14.0619052882
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 14.0619052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 14.0616835633
MESH:D002779 Cholestasis Cyclosporine 11.3319486331
MESH:D002779 Cholestasis Ethinyl Estradiol 11.3316919318 11677210 16105132 15861022 17681005 17110522 17333356
MESH:D002779 Cholestasis pirinixic acid 11.3319176532
MESH:D002822 Choriocarcinoma Tretinoin 4.6816461808
MESH:D002971 Cleft Lip Ethanol 3.3315513904
MESH:D002972 Cleft Palate Ethanol 8.6015513904
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 8.6015668235 8697196 16354765 12621046 15340226
MESH:D002972 Cleft Palate Tretinoin 8.609407595
MESH:D003092 Colitis Selenium 7.9917936198
MESH:D003092 Colitis Tretinoin 7.9917035595
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.6714669216 17141729
MESH:D019465 Craniofacial Abnormalities Ethanol 6.6611873399 15451039 15513904 19302082 15451040 10194807 11198716
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 6.6620055451 15322242 10048152
MESH:D019465 Craniofacial Abnormalities Toluene 6.669294310
MESH:D019465 Craniofacial Abnormalities Tretinoin 6.6617551590 9664655 9142499 14991402 16925845 9211117 10589399 9125849 9224671 8800419
MESH:D019465 Craniofacial Abnormalities Zinc 6.6619302082
MESH:D003456 Cryptorchidism vinclozolin 3.9014966744
MESH:D003643 Death Toluene 5.196431079
MESH:D003711 Demyelinating Diseases Tamoxifen 3.9119031437
MESH:D003872 Dermatitis 3-xylene 5.4315902427 12717741
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.2018249437
MESH:D003920 Diabetes Mellitus Zinc 3.8116479319
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 3.7720387270
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 3.7717107852
MESH:D003928 Diabetic Nephropathies Estradiol 7.5419279558
MESH:D003928 Diabetic Nephropathies Tamoxifen 7.5419279558
MESH:D003929 Diabetic Neuropathies Progesterone 4.0417187935
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 13.1512540782 16109766 10915739 19164858 12705907 16393943 18071297 11739529 14550746 11743745 11529661 12392966 11287661 17562736 17906064 16081117 12153990 10774834 19739265 12594235 14986274 18713872 12958197 15619225 15968718 10663392 14725611 19370779 16781746 19420014 17522070 19923254 11421492 16485898 19416960 2444490 16177239 11461765 11834606 16227642 19085960
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 13.1519336974 16177239 15027814 17522070 3732212 15968718 7179309 19085960 11566570 9327722 6884620 10915739 2869522 4309450 10092053 21278145 6623471 7120509 15998439 7440962 3786805 16227642
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 13.1519107877
MESH:D056486 Drug-Induced Liver Injury Ethanol 13.1511566570
MESH:D056486 Drug-Induced Liver Injury Selenium 13.1515131321
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 13.1520420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.6219426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.4111462148
MESH:D050171 Dyslipidemias Dietary Fats 7.8218367378
MESH:D050171 Dyslipidemias Fenofibrate 7.8216707586
MESH:D004421 Dystonia Phenobarbital 3.581851702
MESH:D004487 Edema perfluorooctanoic acid 9.0917259670 12083418
MESH:D004487 Edema pirinixic acid 9.0912083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 9.0911000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 10.3615322242 18230668 16714409
MESH:D004489 Edema, Cardiac Tretinoin 10.3618230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 12.7712538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 12.7717692515
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 12.7719031437
MESH:D016889 Endometrial Neoplasms Estradiol 15.2519148513 18566989 11473722
MESH:D016889 Endometrial Neoplasms Fenofibrate 15.2516569247
MESH:D016889 Endometrial Neoplasms Tamoxifen 15.2516202921 20544844 17893378 19155303
MESH:D016889 Endometrial Neoplasms Tretinoin 15.2516569247
MESH:D004715 Endometriosis Mifepristone 13.0016134523
MESH:D004715 Endometriosis Progesterone 13.0016134523
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 13.009294722 10568697
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 3.653659116
MESH:D004828 Epilepsies, Partial Phenobarbital 3.403922381 11558140
MESH:D004827 Epilepsy Phenobarbital 2.6420417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.156401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 3.807750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 3.553659116
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 4.6416302075
MESH:D004938 Esophageal Neoplasms 2',3-dimethyl-4-aminobiphenyl 9.381399818
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 9.3816530937
MESH:D004938 Esophageal Neoplasms Ethanol 9.3816704527
MESH:D004938 Esophageal Neoplasms Zinc 9.3816543248
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 7.6711564622
MESH:D005124 Eye Abnormalities Tretinoin 7.679664655 16938888
MESH:D005234 Fatty Liver Carbon Tetrachloride 36.0415959796 17595544 12795759 61145 12631006 16045604 16239168 19224547
MESH:D005234 Fatty Liver Cyclosporine 36.0419224547
MESH:D005234 Fatty Liver Dietary Fats 36.0417967931 19551842 19004024 18296743
MESH:D005234 Fatty Liver Diethylnitrosamine 36.0421071580 20387270
MESH:D005234 Fatty Liver Ethanol 36.0418620774 16409862 19236843
MESH:D005234 Fatty Liver Ethinyl Estradiol 36.0415345470
MESH:D005234 Fatty Liver pirinixic acid 36.0420131406 19236843
MESH:D005234 Fatty Liver Tamoxifen 36.0414986274 19224547
MESH:D005235 Fatty Liver, Alcoholic Ethanol 5.1917920746
MESH:D052776 Female Urogenital Diseases Tamoxifen 2.9416709447
MESH:D005310 Fetal Alcohol Syndrome Ethanol 4.8316946407 15513904 15451040 10194807
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.0011858732
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.0614745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 3.7219069698
MESH:D005355 Fibrosis Carbon Tetrachloride 22.9118705752
MESH:D005355 Fibrosis Cyclosporine 22.9112168785 12639820
MESH:D005355 Fibrosis Dietary Fats 22.9118296743
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 22.9120067830
MESH:D005355 Fibrosis Tretinoin 22.9117994277
MESH:D005391 Firesetting Behavior Testosterone 5.387506515
MESH:D005756 Gastritis Acetaminophen 16.3216983495
MESH:D005756 Gastritis Ethanol 16.3215046732
MESH:D005756 Gastritis Zinc 16.3217241300
MESH:D030342 Genetic Diseases, Inborn vinclozolin 4.4716973722
MESH:D005832 Genital Diseases, Male vinclozolin 4.8216417039
MESH:D005885 Gingival Hyperplasia Cyclosporine 3.758708960
MESH:D005909 Glioblastoma Testosterone 6.4617162496
MESH:D005909 Glioblastoma Tretinoin 6.4617312396
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.1210696789
MESH:D006130 Growth Disorders Zinc 3.6617217573
MESH:D006258 Head and Neck Neoplasms Tretinoin 2.8716096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 4.6816084493
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 9.5820471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 9.5811294989 10048152
MESH:D006330 Heart Defects, Congenital Tretinoin 9.5814991402 9664655
MESH:D006333 Heart Failure pirinixic acid 10.1220558911
MESH:D006333 Heart Failure Selenium 10.1217162251
MESH:D006333 Heart Failure Zinc 10.1217162251
MESH:D006335 Heart Injuries Zinc 5.2917074742
MESH:D016481 Helicobacter Infections Zinc 4.1017241300
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 3.9515720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 2.9211000095
MESH:D006505 Hepatitis Carbon Tetrachloride 3.1619900420 19110552
MESH:D006527 Hepatolenticular Degeneration Zinc 9.8117276780
MESH:D006527 Hepatolenticular Degeneration Zinc Sulfate 9.8117063115
MESH:D006529 Hepatomegaly perfluorooctanoic acid 16.973609246
MESH:D006529 Hepatomegaly Phenobarbital 16.9716109766
MESH:D006529 Hepatomegaly pirinixic acid 16.9719772884 16221962 18467677 19176532
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 16.9715340226 12621046 16120746
MESH:D006558 Herpes Genitalis Estradiol 4.5615709030
MESH:D006628 Hirsutism Testosterone 5.1817019078
MESH:D019584 Hot Flashes Estradiol 3.2817088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.5718606429 16959395 15340226 16354765 8697196
MESH:D006930 Hyperalgesia Acetaminophen 15.6716870215
MESH:D006930 Hyperalgesia Ethanol 15.6718783367
MESH:D006930 Hyperalgesia perfluorooctanoic acid 15.6712083418
MESH:D006930 Hyperalgesia Tretinoin 15.6716870215
MESH:D017588 Hyperandrogenism Testosterone 4.8317019078
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.0716899240
MESH:D006937 Hypercholesterolemia Dietary Fats 3.1821332399
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.1116778211
MESH:D006943 Hyperglycemia pirinixic acid 2.7820558911
MESH:D006949 Hyperlipidemias Dietary Fats 3.1921332399
MESH:D006973 Hypertension Cyclosporine 4.2910903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 4.2918670907 18850075
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 3.6315338365
MESH:D007006 Hypogonadism Testosterone 4.2512002444
MESH:D007018 Hypopituitarism Testosterone 5.7317426086
MESH:D007021 Hypospadias Ethinyl Estradiol 3.3616569931 16945680
MESH:D007022 Hypotension Zinc Sulfate 4.057265320
MESH:D007174 Impulse Control Disorders Testosterone 5.387506515
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 3.9515869954
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.0312013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 5.6117937319
MESH:D007248 Infertility, Male vinclozolin 5.6116467254
MESH:D007249 Inflammation Dietary Fats 20.2920412841
MESH:D007249 Inflammation Diethylnitrosamine 20.2918785209
MESH:D007249 Inflammation Flavonoids 20.2917296493
MESH:D007249 Inflammation perfluorooctanoic acid 20.2912083418
MESH:D007249 Inflammation Progesterone 20.2915869954
MESH:D007249 Inflammation Tamoxifen 20.2919457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 20.2912878042 12200463
MESH:D007251 Influenza, Human Selenium 3.7216624496
MESH:D007333 Insulin Resistance Dietary Fats 10.4811836018 18457598
MESH:D007333 Insulin Resistance Estradiol 10.4816627594 16393666
MESH:D007333 Insulin Resistance pirinixic acid 10.4816306350
MESH:D007410 Intestinal Diseases Tretinoin 3.3217994277
MESH:D007511 Ischemia Zinc 4.1816584753
MESH:D007569 Jaw Abnormalities Ethanol 14.7715513904
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 14.7716580747
MESH:D007569 Jaw Abnormalities Tretinoin 14.7717551590 15992940
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 3.9715604871
MESH:D007674 Kidney Diseases Acetaminophen 12.1315629191 12587719
MESH:D007674 Kidney Diseases Cyclosporine 12.1318776723 10903974 8314463
MESH:D007674 Kidney Diseases Estradiol 12.1315618244
MESH:D007674 Kidney Diseases Zinc 12.1316960431
MESH:D007676 Kidney Failure, Chronic Selenium 8.7016518626
MESH:D007676 Kidney Failure, Chronic Zinc 8.7016518626
MESH:D007680 Kidney Neoplasms Cyclosporine 10.1912371664
MESH:D007680 Kidney Neoplasms Estradiol 10.1915610895
MESH:D007680 Kidney Neoplasms Tamoxifen 10.1918625569
MESH:D007859 Learning Disorders Ethanol 3.7615451040
MESH:D016773 Leishmaniasis, Cutaneous Zinc Sulfate 3.8915237267
MESH:D007938 Leukemia Tretinoin 2.5317143497
MESH:D007951 Leukemia, Myeloid Tretinoin 3.2816482212 16932348 19285840
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 1.9919850784 17596541 16294345
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 2.8417649720 16823087 17712046 16788101 19075265 17294898 19035177 17506722 16891316 12679006 9834237 16766008 19642359 17217047 17361223 16331271 17368321 19225113 16140955 17339181 17301526 16935935 17107899 19029980 15748426
MESH:D007984 Leydig Cell Tumor perfluorooctanoic acid 11.398812269
MESH:D007984 Leydig Cell Tumor vinclozolin 11.3916417039
MESH:D017880 Limb Deformities, Congenital Ethanol 7.1917676605
MESH:D017880 Limb Deformities, Congenital Tretinoin 7.199224671
MESH:D008064 Lipidoses Tamoxifen 2.8215342952 17567588
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 17.8716943688 17334410 11408273 17174718 16221502 11903743 16239168 17157831 21278145
MESH:D008103 Liver Cirrhosis Dietary Fats 17.8718296743
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 17.8720032147 18407596 18665156 19638242 18522880
MESH:D008103 Liver Cirrhosis Ethanol 17.8715289165
MESH:D008103 Liver Cirrhosis Phenobarbital 17.8721047994
MESH:D008104 Liver Cirrhosis, Alcoholic Ethanol 4.6318295389
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 11.9418376398 17631135 15996030 12632512 12586293 16192424 17714472 18263696 15362042 14716833 18251166 10355542 15123356 15052691 16027843 17721639 18429990 18279442 12741479 12958196 18339082 17900296 17708605 13678700 12649538 18205269 18472332 15893842 12632514 18418968 17823541 16097048 18472094 14724832 15057751 16033810 18210741 17525996 16015684 15650968 14716496 12667390 18705752 17766677 11481614 12445421 17481882 17640975 14620537 15876570 16116963 16011737 14748882 17976157 15338365 18187930 17805973 18395095 18412020 12609069 17565644 18156304 15925388 18420326 17869086 15959796 18481824 17698563 16136751 15818738 18166357 14512876 16638106 17944888 18054572 12666154 17557913 15730626 17761835 12546737 18006644 20821823 15370692 12445418 15931870 15673190 17922224 12389079 18277467 18317297 18395914 12898905 16248980
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 11.9414659978 14716833
MESH:D008106 Liver Cirrhosis, Experimental Ethanol 11.9418166357
MESH:D008106 Liver Cirrhosis, Experimental Fenofibrate 11.9415474484
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 11.9415474484
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 11.9418564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 11.9412878042
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 11.9418397230 16248980
MESH:D008107 Liver Diseases Acetaminophen 8.1819460945 11587558 19014921 16610002 12969438 16611625 19784758 12587719
MESH:D008107 Liver Diseases Carbon Tetrachloride 8.1815830285 15720792 16246199 16964402 17285989
MESH:D008107 Liver Diseases Diethylnitrosamine 8.1817034775
MESH:D008107 Liver Diseases Phenobarbital 8.1819363144
MESH:D008108 Liver Diseases, Alcoholic Ethanol 4.2017347304 17207112
MESH:D017093 Liver Failure Carbon Tetrachloride 3.7115123358
MESH:D017114 Liver Failure, Acute Acetaminophen 8.0716871587 17185352
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 8.0716899240 14706259
MESH:D008113 Liver Neoplasms 2-aminofluorene 38.2019499222 19850985 20452335 20492335
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 38.2021137059 20195826
MESH:D008113 Liver Neoplasms beta-Naphthoflavone 38.2021295105 19389873
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 38.2019294768
MESH:D008113 Liver Neoplasms Diethylnitrosamine 38.2019073162 19255062 15885732 21167192 19427195 19254457 2862719 20434301 20501860 19850985 9163691 18977376 16942905 20583210 21071580 15175105 20118626 19294768 19833225 19996281 18978307 19426721 19551842 19690152 19642983 12771043 2422723 21047994 19090486 19812893 20492335 18644402 19256749 18648771 21278145 10737359 18754104 20452335 20137499 20101389 19499222 19638242 20405173 12112319
MESH:D008113 Liver Neoplasms Fenofibrate 38.2018978307
MESH:D008113 Liver Neoplasms gum mastic 38.2018977376
MESH:D008113 Liver Neoplasms perfluorooctanoic acid 38.2014757943 18709148
MESH:D008113 Liver Neoplasms Phenobarbital 38.2019073162 19812893 19482888 21047994 8742319 15975961
MESH:D008113 Liver Neoplasms pirinixic acid 38.2016377806 15890375 20007298
MESH:D008113 Liver Neoplasms Tamoxifen 38.2016684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 38.2016984957
MESH:D008114 Liver Neoplasms, Experimental 2',3-dimethyl-4-aminobiphenyl 28.021399818
MESH:D008114 Liver Neoplasms, Experimental beta-Naphthoflavone 28.0218164116
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 28.0215583823 12014681
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 28.029362446 16267830 18164116 17942915 18093689 3124819 18253720 18544905 19004024 18775883 19126423 19539802 17174075 18079962 2563599 19009564 21159647 17854601 19519916 18282651 16842330 18308698
MESH:D008114 Liver Neoplasms, Experimental Fenofibrate 28.0218253720 18775883
MESH:D008114 Liver Neoplasms, Experimental kojic acid 28.0218544905
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 28.0217172636 18308698 1399818 6150874 2563599
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 28.0212151625
MESH:D008171 Lung Diseases Ozone 3.0619066396 8266340
MESH:D055370 Lung Injury 4-ipomeanol 8.512384072
MESH:D055370 Lung Injury Ozone 8.5120417186
MESH:D008175 Lung Neoplasms 2',3-dimethyl-4-aminobiphenyl 7.631399818
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 7.6320064080 20464547 20869020 18816296 18569708 6695378 17053015 18520028 20135361
MESH:D008175 Lung Neoplasms Diethylnitrosamine 7.6321163286 20512841 20970405 6695378
MESH:D008175 Lung Neoplasms Ozone 7.637614698 8597069
MESH:D008175 Lung Neoplasms Tamoxifen 7.6318625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 7.6311884234 19555203
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 3.3019428831
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 15.5616891317 11807958 11408345 17203775
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 15.5617203775 11408345
MESH:D008325 Mammary Neoplasms, Experimental Selenium 15.5615318939
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 15.5619196722 14580682 19196723 11731420 16827153
MESH:D008325 Mammary Neoplasms, Experimental Zinc 15.5612773700
MESH:D020149 Manganese Poisoning Estradiol 11.0719453300
MESH:D020149 Manganese Poisoning Tamoxifen 11.0719453300
MESH:D008527 Medulloblastoma Tretinoin 2.5917453147
MESH:D008545 Melanoma Tamoxifen 2.9812393984 19393235
MESH:D008545 Melanoma Tretinoin 2.9816752155
MESH:D018328 Melanoma, Amelanotic Tamoxifen 3.7215990972
MESH:D008546 Melanoma, Experimental Acetaminophen 3.1119513568
MESH:D008569 Memory Disorders Ethanol 3.7518411066 15451040
MESH:D008591 Meningomyelocele Tretinoin 3.9716940565
MESH:D008607 Mental Retardation Toluene 3.489294310
MESH:D008654 Mesothelioma Selenium 2.5915107826
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.3116801185
MESH:D008679 Metaplasia Ozone 4.6310496685
MESH:D019957 Motor Skills Disorders Toluene 4.809294310
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 2.8316381670
MESH:D009135 Muscular Diseases pirinixic acid 3.0516239165
MESH:D009190 Myelodysplastic Syndromes Tretinoin 2.8017596541
MESH:D009203 Myocardial Infarction pirinixic acid 1.9419151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.6512213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 7.0616810080
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 7.0616411023
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.0117484760
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 5.059029167 3581430
MESH:D009362 Neoplasm Metastasis Tamoxifen 5.0519393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.3519410462
MESH:D009369 Neoplasms Benzo(a)pyrene 6.7611141357
MESH:D009369 Neoplasms pirinixic acid 6.7617405874
MESH:D009369 Neoplasms Tretinoin 6.7616594593 16946489
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 3.5319189210 19200415 19196722
MESH:D009389 Neovascularization, Pathologic Estradiol 3.2717289903
MESH:D009402 Nephrosis, Lipoid Cyclosporine 3.9717954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 2.8918481113 19348381
MESH:D009421 Nervous System Malformations Estradiol 13.7816427766 11399458
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 13.7814600291
MESH:D009421 Nervous System Malformations Tretinoin 13.789125849
MESH:D009436 Neural Tube Defects Tretinoin 2.759142499
MESH:D019636 Neurodegenerative Diseases Acetaminophen 6.9218514411
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 6.9220387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 4.6420387270
MESH:D020258 Neurotoxicity Syndromes 3-xylene 4.668907413 7820390
MESH:D052556 Niemann-Pick Disease, Type C perfluorooctanoic acid 4.509802331
MESH:D009765 Obesity Dietary Fats 3.9820132043 21332399 19632207 17217161 16723640 18674790 18457598 20518802 11836018
MESH:D009765 Obesity pirinixic acid 3.9820558911
MESH:D010018 Osteomalacia Phenobarbital 3.9017016548
MESH:D010051 Ovarian Neoplasms Estradiol 9.9419401270
MESH:D010051 Ovarian Neoplasms Mifepristone 9.9416525653
MESH:D010051 Ovarian Neoplasms Progesterone 9.9416525653 17393432
MESH:D010051 Ovarian Neoplasms Tretinoin 9.9416936753
MESH:D010146 Pain Acetaminophen 5.3516870215
MESH:D010146 Pain Tretinoin 5.3516870215
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 10.8016540662
MESH:D010190 Pancreatic Neoplasms Ethanol 10.8012384795
MESH:D010190 Pancreatic Neoplasms Phenobarbital 10.8016965848
MESH:D010190 Pancreatic Neoplasms Tretinoin 10.8015976015
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.2611578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 3.7712520081
MESH:D010538 Peritonitis Ozone 3.6816369182
MESH:D010954 Plasmacytoma Selenium 4.4115087411
MESH:D011014 Pneumonia Ozone 3.9318381685 18007984 18929643
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.1218163543
MESH:D011230 Precancerous Conditions Cyclosporine 13.0112371664
MESH:D011230 Precancerous Conditions Diethylnitrosamine 13.012563599
MESH:D011230 Precancerous Conditions Phenobarbital 13.012563599
MESH:D011225 Pre-Eclampsia Zinc 3.8217114810
MESH:D011297 Prenatal Exposure Delayed Effects perfluorooctanoic acid 13.6217132714
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 13.6211222880 11118676 11399792 11896295
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 13.6218042343 18220299 19015723
MESH:D011469 Prostatic Diseases vinclozolin 4.4718220299
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 9.4820887781
MESH:D019048 Prostatic Intraepithelial Neoplasia Testosterone 9.4820887781
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.1917292933
MESH:D011471 Prostatic Neoplasms Estradiol 2.1916740699
MESH:D011471 Prostatic Neoplasms Tamoxifen 2.1915067354
MESH:D011471 Prostatic Neoplasms Zinc 2.1916700911 16517595 16606632 12429649
MESH:D011472 Prostatitis vinclozolin 4.4718629315
MESH:D011507 Proteinuria Tretinoin 3.1816636307
MESH:D011537 Pruritus Ethinyl Estradiol 2.8515861022 16919318
MESH:D019310 Pseudolymphoma Phenobarbital 4.0212752131
MESH:D011565 Psoriasis Cyclosporine 2.0516882103
MESH:D011625 Pterygium Tretinoin 4.3316723453
MESH:D015427 Reperfusion Injury pirinixic acid 2.1519058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.3918990726
MESH:D012162 Retinal Degeneration Zinc 3.7816584753
MESH:D012208 Rhabdomyosarcoma Tretinoin 3.6716283617 16116481
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.6818045962
MESH:D012640 Seizures 3-xylene 11.598907413 6431079
MESH:D012640 Seizures Ethanol 11.599754883
MESH:D012640 Seizures Phenobarbital 11.594039156 11442880 16876388 3137016
MESH:D012640 Seizures Toluene 11.596431079 9294310
MESH:D003294 Seizures, Febrile Phenobarbital 4.366407741
MESH:D012735 Sexual Dysfunction, Physiological Testosterone 5.7316631401
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 8.0110029692 19755658
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 8.0116192470
MESH:D012878 Skin Neoplasms Tretinoin 8.0116467112
MESH:D013088 Spermatocele Ethinyl Estradiol 9.9816709447
MESH:D013088 Spermatocele Tamoxifen 9.9816709447
MESH:D013119 Spinal Cord Injuries Progesterone 9.3215862959 16503802
MESH:D013119 Spinal Cord Injuries Tamoxifen 9.3219457130
MESH:D013274 Stomach Neoplasms 2',3-dimethyl-4-aminobiphenyl 5.801399818
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 5.8020155912 2093021
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 5.8018456281
MESH:D013274 Stomach Neoplasms Ethanol 5.8018456281
MESH:D013274 Stomach Neoplasms Tretinoin 5.8017261132
MESH:D013276 Stomach Ulcer Ethanol 3.1317189318 17918041 9211565 11906479 9562338 16755016
MESH:D013375 Substance Withdrawal Syndrome Ethanol 3.859754883
MESH:D013733 Testicular Diseases Toluene 4.4910514026 10048760
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.1911994571
MESH:D013927 Thrombosis Ethinyl Estradiol 2.7615669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.4312697716
MESH:D013964 Thyroid Neoplasms 2',3-dimethyl-4-aminobiphenyl 14.301399818
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 14.307505956
MESH:D013964 Thyroid Neoplasms Phenobarbital 14.301399818
MESH:D013964 Thyroid Neoplasms Tretinoin 14.3016026305 17045167
MESH:D013978 Tibial Fractures Estradiol 4.2119048282
MESH:D014062 Tongue Neoplasms Tretinoin 8.6416051514
MESH:D014062 Tongue Neoplasms Zinc 8.6416543248
MESH:D014376 Tuberculosis Tretinoin 2.9316040207
MESH:D001749 Urinary Bladder Neoplasms marker/mechanism 18713828
MESH:D001749 Urinary Bladder Neoplasms 2',3-dimethyl-4-aminobiphenyl 17.301399818
MESH:D001749 Urinary Bladder Neoplasms 2-Naphthylamine 17.3011144890
MESH:D001749 Urinary Bladder Neoplasms benzidine 17.3011144890 12500666 16003747
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 17.3017053015
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 17.3016712894 8653321 17572228
MESH:D001749 Urinary Bladder Neoplasms terephthalic acid 17.3016621493 16896691
MESH:D014581 Urticaria Acetaminophen 2.5510982225
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 3.2716129372
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 2.8614692618
MESH:D014604 Uveal Neoplasms Tretinoin 4.1416752155
MESH:D014605 Uveitis Cyclosporine 3.511336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.1212125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.1215869587 14671159
MESH:D014820 Vitiligo Tretinoin 3.6116761959
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 3.7715886252
MESH:D015430 Weight Gain Dietary Fats 3.3516723640
MESH:D009396 Wilms Tumor Tretinoin 3.5716287080
MESH:D014985 Xerophthalmia Cyclosporine 3.9717120751
Pathway ID Pathway Name
REACT:13433 Biological oxidations
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA27119
    • No data
    Releated disease ID Related disease Name
    PA445425Prostatic Neoplasms
    Releated drug ID Related drug Name
    PA449383docetaxel
    PA451644thalidomide
    PA452604xenobiotics
    Drug Bank Top
    No data
    Drugbank ID Action Drug Name Description
    DB00683 substrate Midazolam Anti-anxiety Agents;Hypnotics and Sedatives;Adjuvants, Anesthesia;GABA Modulators;Anesthetics, Intravenous
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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