AutismKB 2.0

Annotation Detail for CYP11A1


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Basic Information Top
Gene Symbol:CYP11A1 ( CYP11A,P450SCC )
Gene Full Name: cytochrome P450, family 11, subfamily A, polypeptide 1
Band: 15q24.1
Quick LinksEntrez ID:1583; OMIM: 118485; Uniprot ID:CP11A_HUMAN; ENSEMBL ID: ENSG00000140459; HGNC ID: 2590
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Pathway IDPathway Name
PWY66-377pregnenolone biosynthesis
Pathway IDPathway Name
hsa00140Steroid hormone biosynthesis
hsa01100Metabolic pathways
Pathway IDPathway Name
Hormone biosynthesis
Metabolism of lipids and lipoproteins
Biological oxidations
No data
No data
Pathway IDPathway Name
500195Endogenous sterols
500773Pregnenolone biosynthesis
Related Diseases/Disorders Top
Desease IDDesease Name
Inherited disorders of lipid/glycolipid metabolism
H00216Congenital adrenal hyperplasia
Genetic disorders
No data
Desease Name
advanced prostate cancer
prostate cancer
CANCER
breast cancer
lung cancer
No data
Desease Name
Lipoid congenital adrenal hyperplasia
Adrenal insufficiency, congenital with or without 46, XY sex reversal
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C003582 11-hydroxyandrostenedione 11-hydroxyandrostenedione results in decreased expression of CYP11A1 mRNAdecreases expression 15858796
C120129 2,2',3,4',5',6-hexachlorobiphenyl 2,2',3,4',5',6-hexachlorobiphenyl results in increased expression of CYP11A1 mRNAincreases expression 16216300
C404910 2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane 2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane affects the activity of CYP11A1 proteinaffects activity 15336722
C404910 2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane 2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane inhibits the reaction [FSHB protein results in increased expression of CYP11A1 mRNA]decreases reaction|increases expression 19414516
16737795
C404910 2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane 2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane results in decreased activity of CYP11A1 proteindecreases activity 18065196
16199348
C404910 2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane 2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane results in decreased expression of CYP11A1 mRNAdecreases expression 10684797
C014024 2,4,5,2',4',5'-hexachlorobiphenyl 2,4,5,2',4',5'-hexachlorobiphenyl results in decreased activity of CYP11A1 proteindecreases activity 16151981
C009828 2,4,5,2',5'-pentachlorobiphenyl 2,4,5,2',5'-pentachlorobiphenyl metabolite results in increased expression of CYP11A1 mRNAincreases expression 16216300
C009828 2,4,5,2',5'-pentachlorobiphenyl 2,4,5,2',5'-pentachlorobiphenyl results in increased expression of CYP11A1 mRNAincreases expression 16216300
C023035 3,4,5,3',4'-pentachlorobiphenyl 3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of CYP11A1 mRNAdecreases expression 12781204
C023035 3,4,5,3',4'-pentachlorobiphenyl 3,4,5,3',4'-pentachlorobiphenyl results in decreased activity of CYP11A1 proteindecreases activity 16151981
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in decreased expression of CYP11A1 mRNAdecreases expression 18648102
D020106 Acrylamide Acrylamide results in decreased expression of CYP11A1 mRNAdecreases expression 15749267
D000324 Adrenocorticotropic Hormone Adrenocorticotropic Hormone results in increased expression of CYP11A1 mRNAincreases expression 16410306
D000324 Adrenocorticotropic Hormone beta-Naphthoflavone inhibits the reaction [Adrenocorticotropic Hormone results in increased expression of CYP11A1 mRNA]decreases reaction|increases expression 16410306
D000324 Adrenocorticotropic Hormone resveratrol inhibits the reaction [beta-Naphthoflavone inhibits the reaction [Adrenocorticotropic Hormone results in increased expression of CYP11A1 mRNA]]decreases reaction|increases expression 16410306
C031143 AICA ribonucleotide AICA ribonucleotide affects the reaction [FSHB protein results in increased expression of CYP11A1 protein]affects reaction|increases expression 16837613
C031143 AICA ribonucleotide AICA ribonucleotide results in increased expression of CYP11A1 proteinincreases expression 17478073
16837613
C011512 alpha-naphthoflavone alpha-naphthoflavone results in decreased expression of CYP11A1 mRNAdecreases expression 15635147
C011512 alpha-naphthoflavone [beta-Naphthoflavone co-treated with alpha-naphthoflavone] results in decreased expression of CYP11A1 mRNAaffects cotreatment|decreases expression 15635147
D017311 Amlodipine Amlodipine results in decreased expression of CYP11A1 mRNAdecreases expression 11086231
D000643 Ammonium Chloride Ammonium Chloride affects the expression of CYP11A1 mRNAaffects expression 16483693
C103016 antalarmin antalarmin results in decreased expression of CYP11A1 mRNAdecreases expression 16014403
C006632 arsenic trioxide arsenic trioxide results in decreased expression of CYP11A1 mRNAdecreases expression 18630931
D001205 Ascorbic Acid Ascorbic Acid inhibits the reaction [Chlorodiphenyl (54% Chlorine) results in decreased activity of CYP11A1 protein]decreases activity|decreases reaction 16298753
D001205 Ascorbic Acid Ascorbic Acid inhibits the reaction [Chlorodiphenyl (54% Chlorine) results in decreased expression of CYP11A1 mRNA]decreases expression|decreases reaction 17280759
C104416 astressin astressin results in decreased expression of CYP11A1 mRNAdecreases expression 16014403
D001280 Atrazine Atrazine results in increased expression of CYP11A1 mRNAincreases expression 18461179
D001280 Atrazine NR5A1 protein promotes the reaction [Atrazine results in increased expression of CYP11A1 mRNA]increases expression|increases reaction 18461179
D001280 Atrazine SGK1 protein affects the reaction [Atrazine results in increased expression of CYP11A1 mRNA]affects reaction|increases expression 18461179
D019324 beta-Naphthoflavone [beta-Naphthoflavone co-treated with alpha-naphthoflavone] results in decreased expression of CYP11A1 mRNAaffects cotreatment|decreases expression 15635147
D019324 beta-Naphthoflavone beta-Naphthoflavone inhibits the reaction [Adrenocorticotropic Hormone results in increased expression of CYP11A1 mRNA]decreases reaction|increases expression 16410306
D019324 beta-Naphthoflavone beta-Naphthoflavone results in decreased expression of CYP11A1 mRNAdecreases expression 15635147
D019324 beta-Naphthoflavone resveratrol inhibits the reaction [beta-Naphthoflavone inhibits the reaction [Adrenocorticotropic Hormone results in increased expression of CYP11A1 mRNA]]decreases reaction|increases expression 16410306
C006780 bisphenol A bisphenol A results in decreased expression of CYP11A1 mRNAdecreases expression 20956811
C006780 bisphenol A bisphenol A results in increased expression of CYP11A1 mRNAincreases expression 12021184
C006780 bisphenol A bisphenol A affects the expression of CYP11A1 mRNAaffects expression 18191889
C006780 bisphenol A [bisphenol A affects the expression of CYP11A1 mRNA] which affects the abundance of Progesteroneaffects abundance|affects expression 18191889
C006780 bisphenol A [bisphenol A affects the expression of CYP11A1 mRNA] which affects the abundance of Testosteroneaffects abundance|affects expression 18191889
C006780 bisphenol A bisphenol A results in decreased expression of CYP11A1 mRNAdecreases expression 15901920
20144698
C006780 bisphenol A bisphenol A results in decreased expression of CYP11A1 proteindecreases expression 20144698
D019256 Cadmium Chloride Cadmium Chloride results in decreased expression of CYP11A1 mRNAdecreases expression 17719163
D002713 Chlorine [Ozone co-treated with Chlorine] results in increased expression of CYP11A1 mRNAaffects cotreatment|increases expression 18636392
D020111 Chlorodiphenyl (54% Chlorine) Ascorbic Acid inhibits the reaction [Chlorodiphenyl (54% Chlorine) results in decreased activity of CYP11A1 protein]decreases activity|decreases reaction 16298753
D020111 Chlorodiphenyl (54% Chlorine) Ascorbic Acid inhibits the reaction [Chlorodiphenyl (54% Chlorine) results in decreased expression of CYP11A1 mRNA]decreases expression|decreases reaction 17280759
D020111 Chlorodiphenyl (54% Chlorine) Chlorodiphenyl (54% Chlorine) results in decreased activity of CYP11A1 proteindecreases activity 16298753
15808795
17283232
D020111 Chlorodiphenyl (54% Chlorine) Chlorodiphenyl (54% Chlorine) results in decreased expression of CYP11A1 mRNAdecreases expression 17280759
17283232
D020111 Chlorodiphenyl (54% Chlorine) Vitamin E inhibits the reaction [Chlorodiphenyl (54% Chlorine) results in decreased activity of CYP11A1 protein]decreases activity|decreases reaction 16298753
D020111 Chlorodiphenyl (54% Chlorine) Vitamin E inhibits the reaction [Chlorodiphenyl (54% Chlorine) results in decreased expression of CYP11A1 mRNA]decreases expression|decreases reaction 17280759
D002772 Cholera Toxin Cholera Toxin results in increased expression of CYP11A1 mRNAincreases expression 11226075
D002772 Cholera Toxin Dichlorodiphenyl Dichloroethylene inhibits the reaction [Cholera Toxin results in increased expression of CYP11A1 mRNA]decreases reaction|increases expression 11226075
D002772 Cholera Toxin Methoxychlor promotes the reaction [Cholera Toxin results in increased expression of CYP11A1 mRNA]increases expression|increases reaction 11226075
D002784 Cholesterol Cholesterol inhibits the reaction [Methoxychlor results in decreased activity of CYP11A1 protein]decreases activity|decreases reaction 8431464
D002784 Cholesterol CYP11A1 protein affects the metabolism of Cholesterolaffects metabolic processing 16054388
D002784 Cholesterol CYP11A1 protein affects the metabolism of Cholesterolaffects metabolic processing 16199348
10888668
D002784 Cholesterol CYP11A1 protein results in increased metabolism of Cholesterolincreases metabolic processing 11226075
D003634 DDT DDT results in increased expression of CYP11A1 mRNAincreases expression 12858341
C007262 deoxynivalenol deoxynivalenol inhibits the reaction [[FSHB protein co-treated with IGF1 protein] results in increased expression of CYP11A1 mRNA]affects cotreatment|decreases reaction|increases expression 17656051
D003993 Dibutyl Phthalate Dibutyl Phthalate results in decreased expression of CYP11A1 mRNAdecreases expression 15987825
14617579
15141095
D003993 Dibutyl Phthalate Dibutyl Phthalate results in decreased expression of CYP11A1 proteindecreases expression 15141095
14617579
16037377
D003633 Dichlorodiphenyl Dichloroethylene Dichlorodiphenyl Dichloroethylene inhibits the reaction [Cholera Toxin results in increased expression of CYP11A1 mRNA]decreases reaction|increases expression 11226075
D003633 Dichlorodiphenyl Dichloroethylene Dichlorodiphenyl Dichloroethylene results in decreased expression of CYP11A1 mRNAdecreases expression 11226075
D019259 Lamivudine [Zidovudine co-treated with Lamivudine] results in decreased expression of CYP11A1 mRNAaffects cotreatment|decreases expression 18313992
D004051 Diethylhexyl Phthalate Diethylhexyl Phthalate results in decreased expression of CYP11A1 mRNAdecreases expression 16690193
D004051 Diethylhexyl Phthalate Diethylhexyl Phthalate results in decreased expression of CYP11A1 proteindecreases expression 16690193
D004054 Diethylstilbestrol Diethylstilbestrol results in decreased expression of CYP11A1 mRNAdecreases expression 12858341
D004054 Diethylstilbestrol Diethylstilbestrol results in increased expression of CYP11A1 mRNAincreases expression 14648872
C025605 diisobutyl phthalate diisobutyl phthalate results in decreased expression of CYP11A1 proteindecreases expression 16458459
D004117 Dimethoate Dimethoate results in decreased activity of CYP11A1 proteindecreases activity 11054639
D004121 Dimethyl Sulfoxide Dimethyl Sulfoxide results in increased expression of CYP11A1 mRNAincreases expression 17365614
D004365 Drugs, Chinese Herbal Drugs, Chinese Herbal results in increased expression of CYP11A1 mRNAincreases expression 14711788
D004365 Drugs, Chinese Herbal Drugs, Chinese Herbal results in decreased activity of CYP11A1 proteindecreases activity 17895526
D004365 Drugs, Chinese Herbal Drugs, Chinese Herbal results in decreased expression of CYP11A1 mRNAdecreases expression 17895526
D004365 Drugs, Chinese Herbal Drugs, Chinese Herbal results in decreased expression of CYP11A1 proteindecreases expression 17895526
D004958 Estradiol Estradiol results in increased expression of CYP11A1 mRNAincreases expression 12858341
D004958 Estradiol Estradiol results in decreased expression of CYP11A1 mRNAdecreases expression 14648872
D004958 Estradiol Estradiol results in decreased expression of CYP11A1 mRNAdecreases expression 20144698
16311018
18191889
D004958 Estradiol Estradiol results in decreased expression of CYP11A1 proteindecreases expression 20144698
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of CYP11A1 mRNAincreases expression 17606305
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of CYP11A1 mRNAincreases expression 17555576
17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CYP11A1 mRNAaffects cotreatment|increases expression 17942748
D004997 Ethinyl Estradiol Ethinyl Estradiol results in decreased expression of CYP11A1 mRNAdecreases expression 15858796
D004997 Ethinyl Estradiol Ethinyl Estradiol results in decreased expression of CYP11A1 mRNAdecreases expression 15834898
15901920
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of CYP11A1 mRNAincreases expression 17365614
D015025 Zearalenone Zearalenone inhibits the reaction [[FSHB protein co-treated with IGF1 protein] results in increased expression of CYP11A1 mRNA]affects cotreatment|decreases reaction|increases expression 17656051
C017690 fenvalerate fenvalerate results in decreased activity of CYP11A1 proteindecreases activity 18053657
C017690 fenvalerate fenvalerate results in decreased expression of CYP11A1 mRNAdecreases expression 18053657
C017690 fenvalerate fenvalerate results in decreased expression of CYP11A1 proteindecreases expression 18053657
C017690 fenvalerate fenvalerate results in decreased expression of CYP11A1 mRNAdecreases expression 15907653
C017690 fenvalerate fenvalerate results in decreased expression of CYP11A1 proteindecreases expression 15907653
C017690 fenvalerate fenvalerate results in increased expression of CYP11A1 mRNAincreases expression 16001830
D005485 Flutamide Flutamide results in increased expression of CYP11A1 mRNAincreases expression 14967917
D005576 Forskolin Forskolin results in increased expression of CYP11A1 mRNAincreases expression 17080404
14691014
D005576 Forskolin Lindane inhibits the reaction [Forskolin results in increased expression of CYP11A1 mRNA]decreases reaction|increases expression 17080404
D018684 Glycine Agents Glycine Agents results in decreased activity of CYP11A1 proteindecreases activity 10964798
C081021 Go 6976 CRH protein inhibits the reaction [Go 6976 results in increased expression of CYP11A1 mRNA]decreases reaction|increases expression 17170093
C081021 Go 6976 Go 6976 results in increased expression of CYP11A1 mRNAincreases expression 17170093
D006064 Gonadotropins, Equine Gonadotropins, Equine inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of CYP11A1 mRNA]decreases expression|decreases reaction 19276399
C473027 GW 3965 GW 3965 results in decreased expression of CYP11A1 mRNAdecreases expression 17449538
D055768 Halogenated Diphenyl Ethers Halogenated Diphenyl Ethers metabolite results in increased expression of CYP11A1 mRNAincreases expression 18313098
D006063 Chorionic Gonadotropin Chorionic Gonadotropin results in increased expression of CYP11A1 mRNAincreases expression 15930178
D006063 Chorionic Gonadotropin Chorionic Gonadotropin results in increased expression of CYP11A1 proteinincreases expression 15930178
D006063 Chorionic Gonadotropin Tetrachlorodibenzodioxin inhibits the reaction [Chorionic Gonadotropin results in increased expression of CYP11A1 mRNA]decreases reaction|increases expression 15930178
D006063 Chorionic Gonadotropin Tetrachlorodibenzodioxin inhibits the reaction [Chorionic Gonadotropin results in increased expression of CYP11A1 protein]decreases reaction|increases expression 15930178
D001556 Lindane Lindane inhibits the reaction [Forskolin results in increased expression of CYP11A1 mRNA]decreases reaction|increases expression 17080404
D001556 Lindane Lindane results in decreased expression of CYP11A1 mRNAdecreases expression 17080404
D001556 Lindane Lindane inhibits the reaction [[FSHB protein co-treated with TGFB1 protein] results in increased expression of CYP11A1 protein]affects cotreatment|decreases reaction|increases expression 15749814
D008687 Metformin Metformin inhibits the reaction [FSH protein results in increased expression of CYP11A1 protein]decreases reaction|increases expression 16760380
D008694 Methamphetamine Methamphetamine results in increased expression of CYP11A1 mRNAincreases expression 19149911
D008731 Methoxychlor Cholesterol inhibits the reaction [Methoxychlor results in decreased activity of CYP11A1 protein]decreases activity|decreases reaction 8431464
D008731 Methoxychlor Methoxychlor binds to and results in decreased activity of CYP11A1 proteinaffects binding|decreases activity 8431464
D008731 Methoxychlor Methoxychlor results in increased expression of CYP11A1 mRNAincreases expression 12858341
D008731 Methoxychlor Methoxychlor metabolite affects the activity of CYP11A1 proteinaffects activity 15336722
D008731 Methoxychlor Methoxychlor metabolite inhibits the reaction [FSHB protein results in increased expression of CYP11A1 mRNA]decreases reaction|increases expression 16737795
D008731 Methoxychlor Methoxychlor metabolite results in decreased activity of CYP11A1 proteindecreases activity 16199348
D008731 Methoxychlor Methoxychlor metabolite results in decreased expression of CYP11A1 mRNAdecreases expression 10684797
D008731 Methoxychlor Methoxychlor results in decreased activity of CYP11A1 proteindecreases activity 16226009
D008731 Methoxychlor Methoxychlor promotes the reaction [Cholera Toxin results in increased expression of CYP11A1 mRNA]increases expression|increases reaction 11226075
D008731 Methoxychlor Methoxychlor results in increased expression of CYP11A1 mRNAincreases expression 11226075
D008797 Metyrapone Metyrapone results in increased expression of CYP11A1 mRNAincreases expression 15265784
D026423 S-Nitroso-N-Acetylpenicillamine S-Nitroso-N-Acetylpenicillamine results in decreased expression of CYP11A1 mRNAdecreases expression 16303614
D026423 S-Nitroso-N-Acetylpenicillamine S-Nitroso-N-Acetylpenicillamine results in decreased expression of CYP11A1 proteindecreases expression 16303614
C025256 nonylphenol nonylphenol affects the expression of CYP11A1 mRNAaffects expression 17365614
D010100 Oxygen Oxygen affects the expression of CYP11A1 mRNAaffects expression 16740971
D010126 Ozone [Ozone co-treated with Chlorine] results in increased expression of CYP11A1 mRNAaffects cotreatment|increases expression 18636392
D010795 Phthalic Acids Phthalic Acids results in decreased expression of CYP11A1 mRNAdecreases expression 15728792
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of CYP11A1 mRNAaffects binding|increases activity|increases expression 19710929
D010936 Plant Extracts Plant Extracts results in decreased activity of CYP11A1 proteindecreases activity 16254570
D010936 Plant Extracts Plant Extracts results in decreased expression of CYP11A1 mRNAdecreases expression 16254570
D010936 Plant Extracts Plant Extracts results in decreased expression of CYP11A1 proteindecreases expression 16254570
C025299 polyphenols polyphenols results in decreased expression of CYP11A1 mRNAdecreases expression 16293270
D011284 Pregnenolone CYP11A1 protein results in increased chemical synthesis of Pregnenoloneincreases chemical synthesis 16054388
D011284 Pregnenolone CYP11A1 protein affects the chemical synthesis of Pregnenoloneaffects chemical synthesis 16199348
10888668
D011284 Pregnenolone CYP11A1 protein results in increased chemical synthesis of Pregnenoloneincreases chemical synthesis 11226075
C045362 prochloraz prochloraz results in decreased expression of CYP11A1 mRNAdecreases expression 19733639
C035988 procymidone procymidone results in increased expression of CYP11A1 mRNAincreases expression 15686871
D011374 Progesterone Progesterone results in increased expression of CYP11A1 mRNAincreases expression 16303614
D011374 Progesterone Progesterone results in increased expression of CYP11A1 proteinincreases expression 16303614
D011374 Progesterone CYP11A1 protein affects the chemical synthesis of Progesteroneaffects chemical synthesis 15819722
D011374 Progesterone [bisphenol A affects the expression of CYP11A1 mRNA] which affects the abundance of Progesteroneaffects abundance|affects expression 18191889
D011374 Progesterone CYP11A1 mRNA affects the abundance of Progesteroneaffects abundance 10964264
C059514 resveratrol resveratrol inhibits the reaction [beta-Naphthoflavone inhibits the reaction [Adrenocorticotropic Hormone results in increased expression of CYP11A1 mRNA]]decreases reaction|increases expression 16410306
D013739 Testosterone CYP11A1 protein affects the chemical synthesis of Testosteroneaffects chemical synthesis 15932923
D013739 Testosterone [bisphenol A affects the expression of CYP11A1 mRNA] which affects the abundance of Testosteroneaffects abundance|affects expression 18191889
D013749 Tetrachlorodibenzodioxin AHR protein promotes the reaction [Tetrachlorodibenzodioxin results in decreased expression of CYP11A1 mRNA]decreases expression|increases reaction 15223135
D013749 Tetrachlorodibenzodioxin AHR protein promotes the reaction [Tetrachlorodibenzodioxin results in decreased expression of CYP11A1 protein]decreases expression|increases reaction 15223135
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CYP11A1 mRNAaffects cotreatment|increases expression 17942748
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of CYP11A1 mRNAdecreases expression 15223135
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of CYP11A1 proteindecreases expression 15223135
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of CYP11A1 mRNAincreases expression 16962184
D013749 Tetrachlorodibenzodioxin Gonadotropins, Equine inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of CYP11A1 mRNA]decreases expression|decreases reaction 19276399
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin inhibits the reaction [Chorionic Gonadotropin results in increased expression of CYP11A1 mRNA]decreases reaction|increases expression 15930178
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin inhibits the reaction [Chorionic Gonadotropin results in increased expression of CYP11A1 protein]decreases reaction|increases expression 15930178
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of CYP11A1 mRNAdecreases expression 16141434
16254025
18637154
19276399
D014050 Toluene Toluene results in increased expression of CYP11A1 mRNAincreases expression 15707876
D014212 Tretinoin Tretinoin results in increased expression of CYP11A1 mRNAincreases expression 16621909
D014212 Tretinoin Tretinoin results in increased expression of CYP11A1 mRNAincreases expression 16604517
D014236 Trichlorfon Trichlorfon results in decreased activity of CYP11A1 proteindecreases activity 17350742
D014236 Trichlorfon Trichlorfon results in decreased expression of CYP11A1 mRNAdecreases expression 17350742
D014236 Trichlorfon Trichlorfon results in decreased expression of CYP11A1 proteindecreases expression 17350742
D014260 Triclosan Triclosan results in decreased expression of CYP11A1 mRNAdecreases expression 19118620
D014635 Valproic Acid Valproic Acid results in decreased expression of CYP11A1 mRNAdecreases expression 19566492
D014635 Valproic Acid Valproic Acid results in increased expression of CYP11A1 mRNAincreases expression 14576182
D014635 Valproic Acid Valproic Acid results in increased expression of CYP11A1 proteinincreases expression 14576182
C034028 vanadyl sulfate vanadyl sulfate results in increased expression of CYP11A1 mRNAincreases expression 16330358
C025643 vinclozolin vinclozolin results in increased expression of CYP11A1 mRNAincreases expression 14967917
C025643 vinclozolin vinclozolin results in increased expression of CYP11A1 proteinincreases expression 14967917
D014810 Vitamin E Vitamin E inhibits the reaction [Chlorodiphenyl (54% Chlorine) results in decreased activity of CYP11A1 protein]decreases activity|decreases reaction 16298753
D014810 Vitamin E Vitamin E inhibits the reaction [Chlorodiphenyl (54% Chlorine) results in decreased expression of CYP11A1 mRNA]decreases expression|decreases reaction 17280759
D014812 Vitamin K Vitamin K affects the expression of CYP11A1 mRNAaffects expression 16844298
D015215 Zidovudine [Zidovudine co-treated with Lamivudine] results in decreased expression of CYP11A1 mRNAaffects cotreatment|decreases expression 18313992
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Diethylhexyl Phthalate 10.096734493
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 10.0911752688 15322242 14514962
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 10.098875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 3.2519490988
MESH:D000038 Abscess Drugs, Chinese Herbal 5.5515043669
MESH:D000138 Acidosis Ammonium Chloride 2.8218287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.1817505938
MESH:D000163 Acquired Immunodeficiency Syndrome Zidovudine 4.109612607
MESH:D058186 Acute Kidney Injury resveratrol 3.1916538975
MESH:D055371 Acute Lung Injury Chlorine 11.4120601635
MESH:D055371 Acute Lung Injury Oxygen 11.4116759491
MESH:D055371 Acute Lung Injury pirinixic acid 11.4118653653
MESH:D000230 Adenocarcinoma arsenic trioxide 5.5011798837 19825857
MESH:D000230 Adenocarcinoma Estradiol 5.5011473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 5.5014692618
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 8.463712494
MESH:D000236 Adenoma beta-Naphthoflavone 8.4619389873
MESH:D000236 Adenoma resveratrol 8.4615688382
MESH:D018248 Adenoma, Liver Cell 3,4,5,3',4'-pentachlorobiphenyl 18.9216628245
MESH:D018248 Adenoma, Liver Cell DDT 18.9212597452
MESH:D018248 Adenoma, Liver Cell pirinixic acid 18.9216434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 18.9216835633
MESH:D000309 Adrenal Insufficiency marker/mechanism
MESH:D000382 Agricultural Workers' Diseases Atrazine 14.5311874814
MESH:D000382 Agricultural Workers' Diseases DDT 14.5312584743 16487989
MESH:D000382 Agricultural Workers' Diseases Dichlorodiphenyl Dichloroethylene 14.5316487989
MESH:D000382 Agricultural Workers' Diseases Lindane 14.5312661182
MESH:D000505 Alopecia Tretinoin 3.0015955085
MESH:D000544 Alzheimer Disease Ozone 7.5415513908
MESH:D000544 Alzheimer Disease Plant Extracts 7.5416962711
MESH:D000544 Alzheimer Disease resveratrol 7.5416183991 16162502
MESH:D000544 Alzheimer Disease Trichlorfon 7.5411419566
MESH:D000550 Amblyopia Valproic Acid 4.4717688650
MESH:D000686 Amyloidosis Diethylstilbestrol 3.7715469931
MESH:D000740 Anemia Drugs, Chinese Herbal 6.8515504547 17963324
MESH:D000740 Anemia Tetrachlorodibenzodioxin 6.8511748828
MESH:D000787 Angina Pectoris Drugs, Chinese Herbal 4.6611477813
MESH:D000860 Anoxia Oxygen 4.3120872349
MESH:D000987 Antisocial Personality Disorder Testosterone 5.097506515
MESH:D001004 Anus Diseases Drugs, Chinese Herbal 5.2015043669
MESH:D001008 Anxiety Disorders Valproic Acid 6.8217497229
MESH:D001008 Anxiety Disorders vinclozolin 6.8219015723
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 2.7411256880
MESH:D018771 Arthralgia Amlodipine 6.219825082
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 13.3815885639
MESH:D001169 Arthritis, Experimental Plant Extracts 13.3814686799
MESH:D001169 Arthritis, Experimental resveratrol 13.3817115116
MESH:D001169 Arthritis, Experimental Tretinoin 13.3816412693
MESH:D015210 Arthritis, Gouty Drugs, Chinese Herbal 5.0019655406
MESH:D001172 Arthritis, Rheumatoid Ozone 3.8415570426
MESH:D001172 Arthritis, Rheumatoid Tretinoin 3.8416292516
MESH:D001249 Asthma Ozone 3.9517854713 16373670
MESH:D001249 Asthma Tretinoin 3.9516456186
MESH:D050197 Atherosclerosis Cholesterol 8.4316632123
MESH:D050197 Atherosclerosis Oxygen 8.4316391483
MESH:D050197 Atherosclerosis resveratrol 8.4317967414 16873680
MESH:D001289 Attention Deficit Disorder with Hyperactivity Phthalic Acids 3.8220106747
MESH:D001321 Autistic Disorder Valproic Acid 2.1419232924 18558336 18177632 15238991 16609825 17507914 18775368 18316065 17157402 18940202 19460635 18985861 17688650 18396377 20603192
MESH:D001471 Barrett Esophagus Tretinoin 3.6916935849
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 4.2611289319 1440618
MESH:D001714 Bipolar Disorder Valproic Acid 2.6420046352 17594078
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 16.4416206674
MESH:D001778 Blood Coagulation Disorders pirinixic acid 16.4419483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 16.4412125929
MESH:D001778 Blood Coagulation Disorders Tretinoin 16.4416206674 16197459
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.0315340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 6.2815746008
MESH:D001848 Bone Diseases, Developmental Valproic Acid 6.288888407
MESH:D001862 Bone Resorption bisphenol A 7.6011985600
MESH:D001862 Bone Resorption Drugs, Chinese Herbal 7.609881647
MESH:D001919 Bradycardia antalarmin 5.6216710322
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 4.5817868700
MESH:D001930 Brain Injuries Progesterone 3.5315845082 15380490 15665606
MESH:D002545 Brain Ischemia Plant Extracts 8.0116041641
MESH:D002545 Brain Ischemia resveratrol 8.0117600658
MESH:D001943 Breast Neoplasms Acrylamide 10.5818183576 16253758
MESH:D001943 Breast Neoplasms Ascorbic Acid 10.5816443354
MESH:D001943 Breast Neoplasms bisphenol A 10.5817123778
MESH:D001943 Breast Neoplasms DDT 10.5816792888 12709520
MESH:D001943 Breast Neoplasms Dichlorodiphenyl Dichloroethylene 10.5815061365
MESH:D001943 Breast Neoplasms Diethylstilbestrol 10.5817129689 15324884
MESH:D001943 Breast Neoplasms Estradiol 10.5817289903 19861407 12948864 17018787 16675129 17261762 14630087 18497071
MESH:D001943 Breast Neoplasms Lindane 10.5814688026
MESH:D001943 Breast Neoplasms Oxygen 10.5817263869
MESH:D001943 Breast Neoplasms Progesterone 10.5815562024 17614352 16175315
MESH:D001943 Breast Neoplasms resveratrol 10.5817534123 17651959 16393696
MESH:D001943 Breast Neoplasms Testosterone 10.5817261762
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 10.5820435547
MESH:D001943 Breast Neoplasms Tretinoin 10.5816166294 16873071 16443354
MESH:D016535 Bronchial Hyperreactivity Ozone 3.0715516495 16777450 18417511 18315731 14754758 17626835 19059883
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 3.8416813970
MESH:D002051 Burkitt Lymphoma arsenic trioxide 3.6311589617
MESH:D002057 Burns, Chemical Plant Extracts 4.589625245
MESH:D002100 Cachexia Ozone 3.9916183385
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 3.7216111702
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 3.2116050911
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.2016835633
MESH:D018236 Carcinoma, Embryonal Tretinoin 4.4016168501
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 16.163581430 7296757
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 16.1615553829 15073043 14691202 11135700 16217749
MESH:D006528 Carcinoma, Hepatocellular DDT 16.1612597452
MESH:D006528 Carcinoma, Hepatocellular Diethylstilbestrol 16.1616924424 15948411
MESH:D006528 Carcinoma, Hepatocellular Estradiol 16.1616924424
MESH:D006528 Carcinoma, Hepatocellular Plant Extracts 16.1618834353
MESH:D006528 Carcinoma, Hepatocellular resveratrol 16.1619321006 16227395
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 16.161917145
MESH:D006528 Carcinoma, Hepatocellular Vitamin K 16.1616328049
MESH:D002278 Carcinoma in Situ bisphenol A 4.2417123778
MESH:D018827 Carcinoma, Lewis Lung resveratrol 3.8516675471
MESH:D002291 Carcinoma, Papillary arsenic trioxide 4.1119014326
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.277296757
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 3.4612490120
MESH:D002294 Carcinoma, Squamous Cell resveratrol 3.8616227395
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 3.8616096774 16051514
MESH:D006332 Cardiomegaly Plant Extracts 5.4117645561
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 5.4118670907 18850075 16120746
MESH:D002318 Cardiovascular Diseases resveratrol 2.9315458977
MESH:D002386 Cataract Tretinoin 2.6117460283
MESH:D002418 Cattle Diseases Acrylamide 9.6112510666
MESH:D002418 Cattle Diseases Trichlorfon 9.6114651886
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 4.857505956
MESH:D002471 Cell Transformation, Neoplastic Estradiol 4.8518566989
MESH:D002547 Cerebral Palsy Toluene 5.109294310
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 3.8416129372
MESH:D002659 Child Development Disorders, Pervasive Testosterone 5.1220678186
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 5.1220734317
MESH:D018281 Cholangiocarcinoma 3,4,5,3',4'-pentachlorobiphenyl 7.6816628245
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 7.6816835633
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 10.019022650 19486331
MESH:D002779 Cholestasis Ethinyl Estradiol 10.0117681005 17110522 16919318 15861022 16105132 11677210 17333356
MESH:D002779 Cholestasis pirinixic acid 10.0119176532
MESH:D002822 Choriocarcinoma Tretinoin 4.4016461808
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 4.4915668235 16354765 12621046 15340226 8697196
MESH:D002972 Cleft Palate Tretinoin 4.499407595
MESH:D003092 Colitis resveratrol 7.2216474422
MESH:D003092 Colitis Tretinoin 7.2217035595
MESH:D003110 Colonic Neoplasms polyphenols 3.4216293270
MESH:D003110 Colonic Neoplasms resveratrol 3.4216338953
MESH:D015179 Colorectal Neoplasms arsenic trioxide 2.3820501625
MESH:D015179 Colorectal Neoplasms resveratrol 2.3816550006
MESH:D003139 Common Cold Ascorbic Acid 4.7217323712
MESH:D000013 Congenital Abnormalities DDT 12.1015095906
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 12.1014669216 17141729
MESH:D000013 Congenital Abnormalities Triclosan 12.1019283420
MESH:D003327 Coronary Disease resveratrol 3.2316507316
MESH:D023903 Coronary Restenosis arsenic trioxide 3.4712609071
MESH:D019465 Craniofacial Abnormalities 3,4,5,3',4'-pentachlorobiphenyl 9.7117686920
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 9.7110525206
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 9.7110048152 15322242 20055451
MESH:D019465 Craniofacial Abnormalities Toluene 9.719294310
MESH:D019465 Craniofacial Abnormalities Tretinoin 9.719142499 17551590 14991402 10589399 9125849 16925845 9224671 9211117 9664655 8800419
MESH:D019465 Craniofacial Abnormalities Valproic Acid 9.7116575769 17688650 8888407
MESH:D019465 Craniofacial Abnormalities Vitamin E 9.7119769572
MESH:D003456 Cryptorchidism Dibutyl Phthalate 15.2616037377
MESH:D003456 Cryptorchidism Diethylstilbestrol 15.2612952375 16002989
MESH:D003456 Cryptorchidism vinclozolin 15.2614966744
MESH:D003643 Death Toluene 4.916431079
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 3.4015213294
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 2.1312868966 11906362 11298694 14531868 18759878 2524372 8156756 8970840
MESH:D003876 Dermatitis, Atopic Diethylhexyl Phthalate 5.6016882537
MESH:D003876 Dermatitis, Atopic pirinixic acid 5.6018249437
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 2.802952479 3621924
MESH:D003920 Diabetes Mellitus Metformin 4.6817446233
MESH:D003921 Diabetes Mellitus, Experimental resveratrol 6.7216873680
MESH:D003921 Diabetes Mellitus, Experimental vanadyl sulfate 6.7216684804
MESH:D003924 Diabetes Mellitus, Type 2 Ascorbic Acid 5.9116506275
MESH:D003924 Diabetes Mellitus, Type 2 Metformin 5.9121186350
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 5.9117107852
MESH:D003925 Diabetic Angiopathies Metformin 5.3116385087
MESH:D003928 Diabetic Nephropathies Estradiol 11.4519279558
MESH:D003928 Diabetic Nephropathies Plant Extracts 11.4519706694
MESH:D003928 Diabetic Nephropathies resveratrol 11.4516286809
MESH:D003929 Diabetic Neuropathies Progesterone 3.7617187935
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 11.3818289764 11289319 9022650 9328219 18692083 9653073 8291058 18648102 7440962 6482804 16192314 6679447 1440618
MESH:D056486 Drug-Induced Liver Injury Chlorodiphenyl (54% Chlorine) 11.3817851650
MESH:D056486 Drug-Induced Liver Injury Drugs, Chinese Herbal 11.3815027814
MESH:D056486 Drug-Induced Liver Injury polyphenols 11.3819370779
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 11.3820420201
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 11.381733752 19641884
MESH:D004362 Drug Toxicity Lamivudine 10.5115040536
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 10.5111462148
MESH:D004362 Drug Toxicity Zidovudine 10.5115040536
MESH:D004417 Dyspnea Chlorine 18.3620016425
MESH:D004417 Dyspnea DDT 18.3616487989
MESH:D004417 Dyspnea Dichlorodiphenyl Dichloroethylene 18.3616487989
MESH:D004417 Dyspnea Oxygen 18.3620016425
MESH:D004421 Dystonia Valproic Acid 3.361851702
MESH:C538011 Eales disease Ascorbic Acid 10.559068938
MESH:C538011 Eales disease Vitamin E 10.559068938
MESH:D004487 Edema pirinixic acid 11.0412083418
MESH:D004487 Edema Plant Extracts 11.0412787963
MESH:D004487 Edema resveratrol 11.048985016
MESH:D004487 Edema Tetrachlorodibenzodioxin 11.0412711302 11000095
MESH:D004489 Edema, Cardiac 3,4,5,3',4'-pentachlorobiphenyl 16.7217686920
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 16.7215322242 18230668 16714409
MESH:D004489 Edema, Cardiac Tretinoin 16.7218230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 11.3012538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 11.3017692515
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental resveratrol 11.3017872969
MESH:D018159 Endolymphatic Hydrops Dimethyl Sulfoxide 5.8020641076
MESH:D004714 Endometrial Hyperplasia Diethylstilbestrol 3.9516402032
MESH:D016889 Endometrial Neoplasms Diethylstilbestrol 9.4116804899 15700306
MESH:D016889 Endometrial Neoplasms Estradiol 9.4119148513 18566989 11473722
MESH:D016889 Endometrial Neoplasms Tretinoin 9.4116569247
MESH:D004715 Endometriosis Progesterone 6.7516134523
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 6.759294722 10568697
MESH:D004719 Endomyocardial Fibrosis Plant Extracts 4.9215268973
MESH:D020345 Enterocolitis, Necrotizing resveratrol 4.1217923197
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 3.4317275665 3659116
MESH:D004828 Epilepsies, Partial Valproic Acid 3.163922381 16628512
MESH:D004827 Epilepsy Plant Extracts 5.4919439326 19700373
MESH:D004827 Epilepsy Valproic Acid 5.4918234410 20417680
MESH:D004832 Epilepsy, Absence Valproic Acid 2.956254150 6426943 7562514
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 3.577750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 3.323659116
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 3.603581430
MESH:D004938 Esophageal Neoplasms arsenic trioxide 3.6012903497
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 6.8911564622
MESH:D005124 Eye Abnormalities Tretinoin 6.899664655 16938888
MESH:D005234 Fatty Liver arsenic trioxide 22.0915073043
MESH:D005234 Fatty Liver Ethinyl Estradiol 22.0915345470
MESH:D005234 Fatty Liver pirinixic acid 22.0919236843 20131406
MESH:D005234 Fatty Liver Plant Extracts 22.0915975614
MESH:D005234 Fatty Liver Valproic Acid 22.0914986274 19224547
MESH:D005234 Fatty Liver Zidovudine 22.0918299183
MESH:D052776 Female Urogenital Diseases Diethylstilbestrol 3.1516513791 16534752 16611131 15751030 16002989
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 2.7311858732
MESH:D005315 Fetal Diseases Valproic Acid 4.1316575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 3.4218558336 8888407
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 4.266705139
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 6.2220067830
MESH:D005355 Fibrosis Tretinoin 6.2217994277
MESH:D005391 Firesetting Behavior Testosterone 5.097506515
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 3.5516904648
MESH:D005739 Gas Poisoning Chlorine 9.5120016425
MESH:D005739 Gas Poisoning Oxygen 9.5120016425
MESH:D030342 Genetic Diseases, Inborn vinclozolin 4.1916973722
MESH:D005832 Genital Diseases, Male vinclozolin 4.5416417039
MESH:D005833 Genital Neoplasms, Female Diethylstilbestrol 4.2016452187
MESH:D005909 Glioblastoma Testosterone 5.7517162496
MESH:D005909 Glioblastoma Tretinoin 5.7517312396
MESH:D005922 Glomerulonephritis, IGA deoxynivalenol 4.4015173396 16524712
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 3.347505956
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 3.8310696789
MESH:D006258 Head and Neck Neoplasms Tretinoin 2.6516096774
MESH:D034381 Hearing Loss Dimethyl Sulfoxide 4.5320641076
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 4.4016084493
MESH:D006330 Heart Defects, Congenital 3,4,5,3',4'-pentachlorobiphenyl 16.2720471113 17686920
MESH:D006330 Heart Defects, Congenital Ascorbic Acid 16.2716080930
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 16.2711294989 10048152
MESH:D006330 Heart Defects, Congenital Tretinoin 16.2714991402 9664655
MESH:D006330 Heart Defects, Congenital Vitamin E 16.2716080930
MESH:D006333 Heart Failure pirinixic acid 5.5620558911
MESH:D006333 Heart Failure Plant Extracts 5.5618097624
MESH:D006402 Hematologic Diseases Zidovudine 4.0212579204
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 2.6611000095
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 16.776705139
MESH:D006505 Hepatitis DDT 16.7716487989
MESH:D006505 Hepatitis Dichlorodiphenyl Dichloroethylene 16.7716487989
MESH:D006505 Hepatitis Drugs, Chinese Herbal 16.7718339527
MESH:D006509 Hepatitis B Lamivudine 4.4217703166
MESH:D019694 Hepatitis B, Chronic Lamivudine 4.4212044531 16476009 15309715 15631357 15274664
MESH:D006529 Hepatomegaly DDT 14.892387028
MESH:D006529 Hepatomegaly fenvalerate 14.8915602828
MESH:D006529 Hepatomegaly pirinixic acid 14.8919772884 16221962 19176532 18467677
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 14.8916120746 15340226 12621046
MESH:D006548 Hernia, Diaphragmatic Ascorbic Acid 5.0116490937 16863852
MESH:D006548 Hernia, Diaphragmatic Vitamin E 5.0116490937 16863852
MESH:D006558 Herpes Genitalis Estradiol 4.2715709030
MESH:D006561 Herpes Simplex Plant Extracts 7.6610715843
MESH:D006561 Herpes Simplex resveratrol 7.6616876885
MESH:D006628 Hirsutism Testosterone 4.8917019078
MESH:D015658 HIV Infections Lamivudine 8.4211141242 9296927 20032539 17530837
MESH:D015658 HIV Infections Plant Extracts 8.4212878215
MESH:D015658 HIV Infections Zidovudine 8.4211363243 17358032 11141242 20032539 11698656
MESH:D019584 Hot Flashes Estradiol 12.7717088409
MESH:D019584 Hot Flashes Plant Extracts 12.7717454163 16566672 14716179
MESH:D019584 Hot Flashes Vitamin E 12.7714716179
MESH:D006849 Hydrocephalus Valproic Acid 4.1217688650
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.2915340226 18606429 8697196 16959395 16354765
MESH:D006930 Hyperalgesia Tretinoin 2.6216870215
MESH:D017588 Hyperandrogenism Flutamide 15.6615356085
MESH:D017588 Hyperandrogenism Metformin 15.6615356085 17062894
MESH:D017588 Hyperandrogenism Testosterone 15.6617019078
MESH:D006937 Hypercholesterolemia Cholesterol 7.4916933029
MESH:D006937 Hypercholesterolemia resveratrol 7.4917188708
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 3.8416778211
MESH:D006943 Hyperglycemia pirinixic acid 2.5320558911
MESH:D020138 Hyperhomocysteinemia Plant Extracts 3.8216484555
MESH:D006948 Hyperkinesis Methamphetamine 4.7617658665
MESH:D006949 Hyperlipidemias Plant Extracts 7.3215268973 15975614
MESH:D006949 Hyperlipidemias resveratrol 7.3216873680
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 8.4215034207
MESH:D006965 Hyperplasia Diethylstilbestrol 8.4212960047 14722030
MESH:D006973 Hypertension Amlodipine 4.7812850387 9825082
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 4.7818850075 18670907
MESH:D017379 Hypertrophy, Left Ventricular resveratrol 3.6417488730
MESH:D007006 Hypogonadism Testosterone 4.0212002444
MESH:D007018 Hypopituitarism Testosterone 5.4417426086
MESH:D007021 Hypospadias Diethylstilbestrol 8.8216002989
MESH:D007021 Hypospadias Ethinyl Estradiol 8.8216945680 16569931
MESH:D007174 Impulse Control Disorders Testosterone 5.097506515
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 9.0715869954
MESH:D020244 Infarction, Middle Cerebral Artery resveratrol 9.0717600658
MESH:D007246 Infertility Diethylstilbestrol 3.6415036965
MESH:D007247 Infertility, Female Acrylamide 8.0911020651
MESH:D007247 Infertility, Female Ethinyl Estradiol 8.0912013081
MESH:D007248 Infertility, Male Acrylamide 27.9615355880 12507653 11020651 15749267
MESH:D007248 Infertility, Male Atrazine 27.9612948887
MESH:D007248 Infertility, Male DDT 27.9617157474 17192596
MESH:D007248 Infertility, Male Dichlorodiphenyl Dichloroethylene 27.9617192596 12948891
MESH:D007248 Infertility, Male Ethinyl Estradiol 27.9617937319
MESH:D007248 Infertility, Male Methoxychlor 27.9616467254 11955947
MESH:D007248 Infertility, Male Triclosan 27.9620821571
MESH:D007248 Infertility, Male vinclozolin 27.9616467254
MESH:D007249 Inflammation Plant Extracts 14.1715997105 12787963 16366677 19332304
MESH:D007249 Inflammation polyphenols 14.1716366677
MESH:D007249 Inflammation Progesterone 14.1715869954
MESH:D007249 Inflammation resveratrol 14.1716366677
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 14.1712200463 12878042
MESH:D007249 Inflammation Triclosan 14.1720507366 9584910
MESH:D007251 Influenza, Human resveratrol 8.5716624496
MESH:D007251 Influenza, Human Vitamin E 8.5716624496
MESH:D007333 Insulin Resistance bisphenol A 13.3716393666
MESH:D007333 Insulin Resistance Estradiol 13.3716393666 16627594
MESH:D007333 Insulin Resistance Metformin 13.3717062894
MESH:D007333 Insulin Resistance pirinixic acid 13.3716306350
MESH:D007410 Intestinal Diseases Tretinoin 3.0417994277
MESH:D007414 Intestinal Neoplasms Plant Extracts 3.9612628509 12584176 12351151
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 4.269022650 8074119
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 7.6916580747
MESH:D007569 Jaw Abnormalities Tretinoin 7.6915992940 17551590
MESH:D007674 Kidney Diseases Cadmium Chloride 7.4116962696
MESH:D007674 Kidney Diseases Estradiol 7.4115618244
MESH:D007674 Kidney Diseases Vitamin E 7.4112488133
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 12.746582329
MESH:D007680 Kidney Neoplasms Diethylstilbestrol 12.7416762066 14681315 15003126
MESH:D007680 Kidney Neoplasms Estradiol 12.7415610895
MESH:D007680 Kidney Neoplasms Zidovudine 12.7412579204
MESH:D007859 Learning Disorders Cholesterol 12.2017134702
MESH:D007859 Learning Disorders DDT 12.207589230
MESH:D007859 Learning Disorders Diethylstilbestrol 12.2017184923
MESH:D007938 Leukemia arsenic trioxide 4.8915070760
MESH:D007938 Leukemia Tretinoin 4.8917143497
MESH:D015451 Leukemia, Lymphocytic, Chronic, B-Cell Drugs, Chinese Herbal 3.5515802533
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 7.6017077332 12560223
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell Zidovudine 7.6020370541
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 3.5616972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 2.8514633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 7.2319077051
MESH:D007951 Leukemia, Myeloid Tretinoin 7.2316482212 19285840 16932348
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 4.9220471514 17050201 19850784 16467208 16968895
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 4.9216294345 19850784 17596541
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 4.9217596541 16294345
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 9.7011468182 19225113 17107899 12018890 19035177 16330433 19642359 11161223 17649720 15336539 16112521 15748426 12712474 16331271 19075265 17217047 9834237 16966277 16891316 12679006 17712046 15213294 16823087 15622746 17869043
MESH:D015473 Leukemia, Promyelocytic, Acute resveratrol 9.7016087638
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 9.7017294898 16766008 16788101 15748426 16891316 19225113 17361223 16935935 17712046 17217047 16823087 16331271 17107899 17301526 19642359 19029980 19035177 17506722 17339181 12679006 17649720 17368321 9834237 16140955 19075265
MESH:D015458 Leukemia, T-Cell arsenic trioxide 3.6416882451
MESH:D007984 Leydig Cell Tumor vinclozolin 3.9916417039
MESH:D017880 Limb Deformities, Congenital Dichlorodiphenyl Dichloroethylene 6.7512745335
MESH:D017880 Limb Deformities, Congenital Tretinoin 6.759224671
MESH:C537027 Lipoid congenital adrenal hyperplasia marker/mechanism
MESH:D008103 Liver Cirrhosis Drugs, Chinese Herbal 5.8317163593
MESH:D008103 Liver Cirrhosis Plant Extracts 5.8317157831
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 2.689327722 15034207
MESH:D008106 Liver Cirrhosis, Experimental Dimethyl Sulfoxide 10.6111682029
MESH:D008106 Liver Cirrhosis, Experimental Drugs, Chinese Herbal 10.6115744066 15754396 16610055 15818738 18606216 18237412 15763062 12632512 15641146 17881167 17036385 18371158 15383259 15864749 15849816 17629604 17666798 17348192 15339415 18567088
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 10.6114716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 10.6115474484
MESH:D008106 Liver Cirrhosis, Experimental Plant Extracts 10.6115479170
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 10.6112878042
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 10.6118397230 16248980
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 10.6116169303
MESH:D008107 Liver Diseases DDT 9.7215729006
MESH:D008107 Liver Diseases Drugs, Chinese Herbal 9.7217207593
MESH:D008107 Liver Diseases Lindane 9.721715830
MESH:D008107 Liver Diseases Plant Extracts 9.7217034775
MESH:D008107 Liver Diseases polyphenols 9.7216698588
MESH:D008113 Liver Neoplasms 2,4,5,2',4',5'-hexachlorobiphenyl 30.0816835634 18644402
MESH:D008113 Liver Neoplasms arsenic trioxide 30.0814682389
MESH:D008113 Liver Neoplasms beta-Naphthoflavone 30.0819389873 21295105
MESH:D008113 Liver Neoplasms DDT 30.0811948501 15975961
MESH:D008113 Liver Neoplasms Diethylhexyl Phthalate 30.0811940454
MESH:D008113 Liver Neoplasms Diethylstilbestrol 30.0815890375 16712894
MESH:D008113 Liver Neoplasms Drugs, Chinese Herbal 30.0818339527
MESH:D008113 Liver Neoplasms pirinixic acid 30.0820007298 16377806 15890375
MESH:D008113 Liver Neoplasms Plant Extracts 30.0819168119
MESH:D008113 Liver Neoplasms resveratrol 30.0819812893 20405173 19321006 19073162
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 30.0816984957
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 13.26598648 3712494 6587162 1399818
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 13.2620377131
MESH:D008114 Liver Neoplasms, Experimental Ascorbic Acid 13.2618544905
MESH:D008114 Liver Neoplasms, Experimental beta-Naphthoflavone 13.2618164116
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 13.2612151625
MESH:D008133 Long QT Syndrome arsenic trioxide 2.7615213294
MESH:D008171 Lung Diseases Ascorbic Acid 9.3416863852
MESH:D008171 Lung Diseases Ozone 9.3419066396 8266340
MESH:D008171 Lung Diseases Vitamin E 9.3416863852
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 3.5017228818
MESH:D055370 Lung Injury Oxygen 7.0318339021
MESH:D055370 Lung Injury Ozone 7.0320417186
MESH:D008175 Lung Neoplasms arsenic trioxide 10.4011798837 19825857
MESH:D008175 Lung Neoplasms Ascorbic Acid 10.4016401635
MESH:D008175 Lung Neoplasms Drugs, Chinese Herbal 10.4018339527
MESH:D008175 Lung Neoplasms Ozone 10.408597069 7614698
MESH:D008175 Lung Neoplasms Plant Extracts 10.4020869020
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 10.4019555203 11884234
MESH:D008175 Lung Neoplasms Vitamin E 10.4011062179
MESH:D008175 Lung Neoplasms Zidovudine 10.4018800350
MESH:D008181 Lupus Nephritis Diethylstilbestrol 4.4015166399
MESH:D008223 Lymphoma Diethylstilbestrol 2.9215700306
MESH:D016393 Lymphoma, B-Cell resveratrol 3.6117088997
MESH:D008228 Lymphoma, Non-Hodgkin resveratrol 3.2514749477
MESH:D052801 Male Urogenital Diseases Diethylstilbestrol 4.7516002989
MESH:D015674 Mammary Neoplasms, Animal resveratrol 3.5115688416
MESH:D008325 Mammary Neoplasms, Experimental Drugs, Chinese Herbal 13.3614758024
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 13.3611807958 16891317 11408345 17203775
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 13.3611408345 17203775
MESH:D008325 Mammary Neoplasms, Experimental resveratrol 13.368985016 11606380
MESH:D008325 Mammary Neoplasms, Experimental Triclosan 13.3615358634
MESH:D020149 Manganese Poisoning Estradiol 3.7219453300
MESH:D008527 Medulloblastoma Tretinoin 2.4317453147
MESH:D008545 Melanoma resveratrol 2.8817992120
MESH:D008545 Melanoma Tretinoin 2.8816752155
MESH:D008569 Memory Disorders Trichlorfon 5.0015957009
MESH:D008591 Meningomyelocele Tretinoin 3.6916940565
MESH:D008607 Mental Retardation Toluene 3.349294310
MESH:D008654 Mesothelioma Atrazine 3.171916698
MESH:D008659 Metabolic Diseases resveratrol 3.7017112576
MESH:D008679 Metaplasia Ozone 4.3510496685
MESH:D048629 Micronuclei, Chromosome-Defective Zidovudine 5.0817358032
MESH:D008881 Migraine Disorders Valproic Acid 2.6418765137 18803445
MESH:D019957 Motor Skills Disorders Toluene 4.549294310
MESH:D009101 Multiple Myeloma arsenic trioxide 5.5619417148 14977855 11468182 15949261 19549372
MESH:D009101 Multiple Myeloma resveratrol 5.5617164350 16267019 14749477 16490592 17935668 17049120
MESH:D009134 Muscular Atrophy, Spinal resveratrol 4.1217962980
MESH:D009135 Muscular Diseases pirinixic acid 2.7816239165
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 3.358888407
MESH:D009182 Mycosis Fungoides arsenic trioxide 3.9118349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 9.5116882451 16105982
MESH:D009190 Myelodysplastic Syndromes Tretinoin 9.5117596541
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 9.5117596541
MESH:D009203 Myocardial Infarction pirinixic acid 4.4819151258
MESH:D009203 Myocardial Infarction resveratrol 4.4817188708 16317513 16525036 17125593 17015251 16456233
MESH:D017202 Myocardial Ischemia resveratrol 6.9817125593 17015251
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 6.9812213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 6.2716810080
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 6.2716411023
MESH:D009205 Myocarditis resveratrol 4.0117322642
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 3.2516624393
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 2.123581430
MESH:D009369 Neoplasms 2,4,5,2',4',5'-hexachlorobiphenyl 17.428820588
MESH:D009369 Neoplasms DDT 17.428820588
MESH:D009369 Neoplasms Diethylstilbestrol 17.4215313581
MESH:D009369 Neoplasms fenvalerate 17.422895627
MESH:D009369 Neoplasms Lindane 17.4212807735 16818664
MESH:D009369 Neoplasms pirinixic acid 17.4217405874
MESH:D009369 Neoplasms Tretinoin 17.4216594593 16946489
MESH:D009374 Neoplasms, Experimental resveratrol 3.288985016
MESH:D009389 Neovascularization, Pathologic Estradiol 2.9917289903
MESH:D009410 Nerve Degeneration Acrylamide 4.1012387366 11264303 12387367
MESH:D009422 Nervous System Diseases Acrylamide 4.3512164553 12507653
MESH:D009421 Nervous System Malformations bisphenol A 23.2711399458 16427766
MESH:D009421 Nervous System Malformations Diethylstilbestrol 23.2711399458
MESH:D009421 Nervous System Malformations Estradiol 23.2716427766 11399458
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 23.2714600291
MESH:D009421 Nervous System Malformations Tretinoin 23.279125849
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 12.986679447
MESH:D009436 Neural Tube Defects arsenic trioxide 12.9810525206
MESH:D009436 Neural Tube Defects Tretinoin 12.989142499
MESH:D009436 Neural Tube Defects Valproic Acid 12.988888407 16359493
MESH:D019954 Neurobehavioral Manifestations Plant Extracts 4.4517168769
MESH:D019636 Neurodegenerative Diseases resveratrol 3.1917652729
MESH:D020078 Neurogenic Inflammation resveratrol 3.7117929310
MESH:D009468 Neuromuscular Diseases Amlodipine 6.209825082
MESH:D052556 Niemann-Pick Disease, Type C Cholesterol 4.9720557099 9802331
MESH:D009765 Obesity Ascorbic Acid 6.0817217161
MESH:D009765 Obesity pirinixic acid 6.0820558911
MESH:D009765 Obesity Plant Extracts 6.0820132043 19056576
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 2.774026338 6482804
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 4.263988306
MESH:D015663 Osteoporosis, Postmenopausal Drugs, Chinese Herbal 8.1816548355
MESH:D015663 Osteoporosis, Postmenopausal resveratrol 8.1817513867
MESH:D010049 Ovarian Diseases bisphenol A 4.2411985600
MESH:D010051 Ovarian Neoplasms arsenic trioxide 8.7119769630 16624393 12452020
MESH:D010051 Ovarian Neoplasms Estradiol 8.7119401270
MESH:D010051 Ovarian Neoplasms Progesterone 8.7117393432 16525653
MESH:D010051 Ovarian Neoplasms Tretinoin 8.7116936753
MESH:D010146 Pain Tretinoin 2.3216870215
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 4.1615580305
MESH:D010190 Pancreatic Neoplasms Tretinoin 4.1615976015
MESH:D016584 Panic Disorder Ethinyl Estradiol 2.9911578682
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 7.067296757
MESH:D010212 Papilloma Plant Extracts 7.0615173996 16517061
MESH:D010235 Paraganglioma arsenic trioxide 3.4719927285
MESH:D010243 Paralysis fenvalerate 5.268952708
MESH:D010300 Parkinson Disease Atrazine 2.9517218051
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 3.4912520081
MESH:D010523 Peripheral Nervous System Diseases Acrylamide 4.4011510240
MESH:D010538 Peritonitis Ozone 3.4116369182
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 3.716228378
MESH:D010900 Pituitary Diseases Diethylstilbestrol 4.4114722030
MESH:D010911 Pituitary Neoplasms Diethylstilbestrol 3.9415687265 16977796
MESH:D011000 Pleurodynia, Epidemic Amlodipine 6.769825082
MESH:D011014 Pneumonia Ozone 3.6518381685 18007984 18929643
MESH:D011085 Polycystic Ovary Syndrome Flutamide 8.6615356085
MESH:D011085 Polycystic Ovary Syndrome Metformin 8.6617062894 15356085
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 2.8518163543
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 28.3310548101
MESH:D011297 Prenatal Exposure Delayed Effects Diethylstilbestrol 28.3317184923
MESH:D011297 Prenatal Exposure Delayed Effects resveratrol 28.3316679765
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 28.3311896295 11118676 11222880 11399792
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 28.3320603192
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 28.3318220299 18042343 19015723
MESH:D011469 Prostatic Diseases vinclozolin 4.1918220299
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 14.1520887781
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 14.1520887781
MESH:D019048 Prostatic Intraepithelial Neoplasia Testosterone 14.1520887781
MESH:D011471 Prostatic Neoplasms arsenic trioxide 2.9919131511
MESH:D011471 Prostatic Neoplasms bisphenol A 2.9916740699
MESH:D011471 Prostatic Neoplasms DDT 2.9912584743
MESH:D011471 Prostatic Neoplasms Diethylstilbestrol 2.9917136230 15846301 15046698
MESH:D011471 Prostatic Neoplasms Estradiol 2.9916740699
MESH:D011471 Prostatic Neoplasms Flutamide 2.993169114
MESH:D011471 Prostatic Neoplasms Lindane 2.9914688026 12661182
MESH:D011471 Prostatic Neoplasms Plant Extracts 2.9917804756 14666653
MESH:D011471 Prostatic Neoplasms resveratrol 2.9917636462 16731767 17675339 17718901 17804756 15767336
MESH:D011471 Prostatic Neoplasms Vitamin E 2.9915084515
MESH:D011472 Prostatitis vinclozolin 4.1918629315
MESH:D011507 Proteinuria Tretinoin 2.9216636307
MESH:D011537 Pruritus Ethinyl Estradiol 2.5815861022 16919318
MESH:D019310 Pseudolymphoma Valproic Acid 3.7812752131 11422049
MESH:D011625 Pterygium Tretinoin 4.0516723453
MESH:D011629 Puberty, Precocious bisphenol A 4.0410548101
MESH:D011657 Pulmonary Eosinophilia Ascorbic Acid 4.5714606601
MESH:D011658 Pulmonary Fibrosis Drugs, Chinese Herbal 3.3816987627
MESH:D012003 Rectal Fistula Drugs, Chinese Herbal 5.2015043669
MESH:D051436 Renal Insufficiency, Chronic resveratrol 4.8216325855
MESH:D015427 Reperfusion Injury pirinixic acid 5.1419058328
MESH:D015427 Reperfusion Injury resveratrol 5.1415827377 16314181 17520802 16317513 17058453
MESH:D012120 Respiration Disorders Chlorine 4.4518579056
MESH:D012128 Respiratory Distress Syndrome, Adult Oxygen 3.8218339021 17627322
MESH:D012135 Respiratory Sounds Atrazine 3.8011874814
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.1218990726
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 2.793692021
MESH:D012174 Retinitis Pigmentosa Ascorbic Acid 3.0516849425
MESH:D012206 Rhabdomyolysis Lamivudine 4.799296927
MESH:D012208 Rhabdomyosarcoma Tretinoin 8.5616283617 16116481
MESH:D012208 Rhabdomyosarcoma Valproic Acid 8.5619155313
MESH:D012221 Rhinitis, Allergic, Perennial Drugs, Chinese Herbal 4.5215015336
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.5318045962
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 3.2516646077
MESH:D012559 Schizophrenia Valproic Acid 1.9519110320 15737665
MESH:D012640 Seizures Lindane 7.0012842176 15475178 7539098
MESH:D012640 Seizures Toluene 7.009294310 6431079
MESH:D012640 Seizures Valproic Acid 7.0011044598 17978042 3137016 11738929 14763951 15475178 1511512 16876388
MESH:D012735 Sexual Dysfunction, Physiological Testosterone 5.4416631401
MESH:D012871 Skin Diseases Ascorbic Acid 4.3318709164
MESH:D012871 Skin Diseases Vitamin E 4.3318709164
MESH:D012878 Skin Neoplasms Plant Extracts 10.1716517061 15173996
MESH:D012878 Skin Neoplasms resveratrol 10.1715837718 8985016
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 10.1716192470
MESH:D012878 Skin Neoplasms Tretinoin 10.1716467112
MESH:D013088 Spermatocele Diethylstilbestrol 9.1916002989 16709447
MESH:D013088 Spermatocele Ethinyl Estradiol 9.1916709447
MESH:D013119 Spinal Cord Injuries Progesterone 3.5415862959 16503802
MESH:D016135 Spinal Dysraphism Valproic Acid 3.1819490988
MESH:D013226 Status Epilepticus Valproic Acid 3.7812833885
MESH:D013274 Stomach Neoplasms arsenic trioxide 3.8717007042
MESH:D013274 Stomach Neoplasms Drugs, Chinese Herbal 3.8718339527
MESH:D013274 Stomach Neoplasms Tretinoin 3.8717261132
MESH:D013274 Stomach Neoplasms Zidovudine 3.8717696246
MESH:D013276 Stomach Ulcer Ascorbic Acid 5.6518726076
MESH:D013276 Stomach Ulcer Plant Extracts 5.6518193104 12787963 15255614 17135157 18237397
MESH:D020521 Stroke Ascorbic Acid 6.8616403987 16517955
MESH:D020521 Stroke Vitamin E 6.8616517955
OMIM:601367 STROKE, ISCHEMIC resveratrol 3.8216321402
MESH:D013322 Strongyloidiasis Trichlorfon 5.8714651886
MESH:D013345 Subarachnoid Hemorrhage Drugs, Chinese Herbal 5.0017634840
MESH:D019966 Substance-Related Disorders bisphenol A 3.2516684133 16045194
MESH:D013398 Sudden Infant Death Oxygen 4.8012563064
MESH:D013705 Temporomandibular Joint Disorders Plant Extracts 10.7517997062
MESH:D013705 Temporomandibular Joint Disorders polyphenols 10.7517997062
MESH:D013733 Testicular Diseases Acrylamide 8.5415864552
MESH:D013733 Testicular Diseases Toluene 8.5410514026 10048760
MESH:D019851 Thrombophilia Ethinyl Estradiol 2.9311994571
MESH:D013927 Thrombosis Ethinyl Estradiol 2.5115669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 9.9812697716
MESH:D013959 Thyroid Diseases Triclosan 9.9819910387
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 8.566582329 1399818 6587162 3712494 7505956
MESH:D013964 Thyroid Neoplasms arsenic trioxide 8.5619014326
MESH:D013964 Thyroid Neoplasms Tretinoin 8.5616026305 17045167
MESH:D013978 Tibial Fractures Estradiol 3.9219048282
MESH:D014062 Tongue Neoplasms resveratrol 7.7216227395
MESH:D014062 Tongue Neoplasms Tretinoin 7.7216051514
MESH:D016171 Torsades de Pointes arsenic trioxide 3.2215213294
MESH:D014178 Translocation, Genetic Valproic Acid 4.4717262798
MESH:D014202 Tremor fenvalerate 4.818952708
MESH:D014376 Tuberculosis Tretinoin 2.7216040207
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 3.783119515
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 6.258074119
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 6.2511780464 20435036 12973940 12845720
MESH:D001749 Urinary Bladder Neoplasms Diethylstilbestrol 6.2517306315 16452187 16712894
MESH:D014564 Urogenital Abnormalities Valproic Acid 3.918888407
MESH:D014570 Urologic Diseases DDT 10.2016487989
MESH:D014570 Urologic Diseases Dichlorodiphenyl Dichloroethylene 10.2016487989
MESH:D002583 Uterine Cervical Neoplasms Diethylstilbestrol 12.1316175088
MESH:D002583 Uterine Cervical Neoplasms resveratrol 12.1317473185
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 12.1316129372
MESH:D014591 Uterine Diseases bisphenol A 11.2914652134
MESH:D014591 Uterine Diseases Diethylstilbestrol 11.2914652134
MESH:D014594 Uterine Neoplasms Diethylstilbestrol 11.9816690809 15809267
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 11.9814692618
MESH:D014594 Uterine Neoplasms resveratrol 11.9817044934
MESH:D014604 Uveal Neoplasms Tretinoin 3.8516752155
MESH:D014625 Vaginal Neoplasms Diethylstilbestrol 8.7216002989 16513791
MESH:D014625 Vaginal Neoplasms Zidovudine 8.7212579204
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 3.8312125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 2.8614671159 15869587
MESH:D018487 Ventricular Dysfunction, Left Plant Extracts 8.1218097624
MESH:D018487 Ventricular Dysfunction, Left resveratrol 8.1217488730
MESH:D020257 Ventricular Remodeling Plant Extracts 4.5718097624
MESH:D014820 Vitiligo Tretinoin 3.3516761959
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 3.4915886252
MESH:D009396 Wilms Tumor Tretinoin 3.3216287080
MESH:D014947 Wounds and Injuries Drugs, Chinese Herbal 7.0616313111
MESH:D014947 Wounds and Injuries Plant Extracts 7.0620213670 19894650
Pathway ID Pathway Name
REACT:13433 Biological oxidations
REACT:15314 Hormone biosynthesis
KEGG:01100 Metabolic pathways
REACT:22258 Metabolism of lipids and lipoproteins
KEGG:00140 Steroid hormone biosynthesis
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA27089
    • No data
    No data
    Releated drug ID Related drug Name
    PA449512estrone
    PA451123progesterone
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB00357 antagonist Aminoglutethimide Antineoplastic Agents;Adrenergic Agents;Antineoplastic Agents, Hormonal;Aromatase Inhibitors
    Drugbank ID Action Drug Name Description
    DB00169 substrate Women's Timed Release Ultra Mega Without Iron Essential Vitamin;Antihypocalcemic Agents;Antihypoparathyroid Agents;Vitamins (Vitamin D);Bone Density Conservation Agents;Vitamins
    DB00257 - Lotrisone Antifungal Agents;Anti-Infective Agents, Local;Growth Inhibitors
    DB00338 inhibitor Omeprazole Anti-Ulcer Agents;Enzyme Inhibitors;Proton-pump Inhibitors
    DB00390 - Digoxin Enzyme Inhibitors;Antiarrhythmic Agents;Cardiotonic Agents;Anti-Arrhythmia Agents
    DB00396 - Synovex S Contraceptives;Progestins
    DB00501 - Cimetidine Anti-Ulcer Agents;Analgesics;Enzyme Inhibitors;Adjuvants;Histamine Antagonists;Histamine H2 Antagonists
    DB00624 - Uni-Bol Androgens
    DB00857 inhibitor Terbinafine Antifungals;Enzyme Inhibitors;Antifungal Agents;Trypanocidal Agents;Allylamines
    DB00882 inhibitor Clomifene Selective Estrogen Receptor Modulators;Estrogen Antagonists;Fertility Agents, Female
    DB00917 substrate Dinoprostone Oxytocics;Prostaglandins
    DB01026 inhibitor Ketoconazole Antifungals;Antifungal Agents
    DB01092 - Ouabain Enzyme Inhibitors;Cardiotonic Agents
    DB01108 - Trilostane Antiadrenal;Anticorticosteroids
    DB01232 substrate Saquinavir Anti-HIV Agents;HIV Protease Inhibitors
    DB01234 inhibitor Tresaderm Dermatologic Solution Anti-inflammatory Agents;Adrenergic Agents;Antiemetics;Antineoplastic Agents, Hormonal;Glucocorticoids
    DB01396 - Digitoxin Enzyme Inhibitors;Antiarrhythmic Agents;Cardiotonic Agents;Anti-Arrhythmia Agents
    DB01437 inhibitor Glutethimide Hypnotics and Sedatives
    DB02901 substrate Dihydrotestosterone Androgens;Steroidal
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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