AutismKB 2.0

Annotation Detail for CYP11B1


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Basic Information Top
Gene Symbol:CYP11B1 ( CPN1,CYP11B,DKFZp686B05283,FHI,FLJ36771,P450C11 )
Gene Full Name: cytochrome P450, family 11, subfamily B, polypeptide 1
Band: 8q24.3
Quick LinksEntrez ID:1584; OMIM: 610613; Uniprot ID:C11B1_HUMAN; ENSEMBL ID: ENSG00000160882; HGNC ID: 2591
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Pathway IDPathway Name
PWY66-381glucocorticoid biosynthesis
Pathway IDPathway Name
hsa00140Steroid hormone biosynthesis
hsa01100Metabolic pathways
Pathway IDPathway Name
Hormone biosynthesis
Metabolism of lipids and lipoproteins
Biological oxidations
No data
No data
Pathway IDPathway Name
500195Endogenous sterols
500772Steroid hormones
500775Mineralocorticoid biosynthesis
500774Glucocorticoid biosynthesis
500832Metabolism of steroid hormones and vitamin D
Related Diseases/Disorders Top
Desease IDDesease Name
Inherited disorders of lipid/glycolipid metabolism
H00216Congenital adrenal hyperplasia
Genetic disorders
No data
Desease Name
PHARMACOGENOMIC
METABOLIC
11beta-hydroxylase activity
aldosterone
No data
Desease Name
Aldosteronism, glucocorticoid-remediable
Adrenal hyperplasia, congenital, due to 11-beta-hydroxylase deficiency
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C003582 11-hydroxyandrostenedione 11-hydroxyandrostenedione results in decreased expression of CYP11B1 mRNAdecreases expression 15858796
C033689 18-hydroxycortisol CYP11B1 protein affects the chemical synthesis of 18-hydroxycortisolaffects chemical synthesis 15356073
C042509 18-hydroxydeoxycorticosterone 18-hydroxydeoxycorticosterone results in decreased activity of CYP11B1 proteindecreases activity 11549669
C094859 2,2',3,3',4,6'-hexachlorobiphenyl 2,2',3,3',4,6'-hexachlorobiphenyl results in increased expression of CYP11B1 mRNAincreases expression 16396990
C120129 2,2',3,4',5',6-hexachlorobiphenyl 2,2',3,4',5',6-hexachlorobiphenyl metabolite inhibits the reaction [2,2',3,4',5',6-hexachlorobiphenyl results in increased expression of CYP11B1 mRNA]decreases reaction|increases expression 16216300
C120129 2,2',3,4',5',6-hexachlorobiphenyl 2,2',3,4',5',6-hexachlorobiphenyl results in increased expression of CYP11B1 mRNAincreases expression 16216300
C087667 2,3,3',4,4',5-hexachlorobiphenyl 2,3,3',4,4',5-hexachlorobiphenyl results in increased expression of CYP11B1 mRNAincreases expression 16396990
C009828 2,4,5,2',5'-pentachlorobiphenyl 2,4,5,2',5'-pentachlorobiphenyl metabolite inhibits the reaction [2,4,5,2',5'-pentachlorobiphenyl results in increased expression of CYP11B1 mRNA]decreases reaction|increases expression 16216300
C009828 2,4,5,2',5'-pentachlorobiphenyl 2,4,5,2',5'-pentachlorobiphenyl results in increased expression of CYP11B1 mRNAincreases expression 16216300
C104564 2-(4-acetoxyphenyl)-2-chloro-N-methylethylamine 2-(4-acetoxyphenyl)-2-chloro-N-methylethylamine results in decreased activity of CYP11B1 proteindecreases activity 9037251
C104564 2-(4-acetoxyphenyl)-2-chloro-N-methylethylamine 2-(4-acetoxyphenyl)-2-chloro-N-methylethylamine results in decreased activity of CYP11B1 proteindecreases activity 9037251
C028451 3,4,3',4'-tetrachlorobiphenyl 3,4,3',4'-tetrachlorobiphenyl results in increased expression of CYP11B1 mRNAincreases expression 16396990
C027309 3,4,5,3',4',5'-hexachlorobiphenyl 3,4,5,3',4',5'-hexachlorobiphenyl results in increased expression of CYP11B1 mRNAincreases expression 16396990
C023035 3,4,5,3',4'-pentachlorobiphenyl 3,4,5,3',4'-pentachlorobiphenyl results in increased activity of CYP11B1 proteinincreases activity 15703266
C023035 3,4,5,3',4'-pentachlorobiphenyl 3,4,5,3',4'-pentachlorobiphenyl results in increased expression of CYP11B1 mRNAincreases expression 16216300
16396990
15703266
C023035 3,4,5,3',4'-pentachlorobiphenyl 3',4'-dimethoxyflavone promotes the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of CYP11B1 mRNA]increases expression|increases reaction 16396990
C509288 3',4'-dimethoxyflavone 3',4'-dimethoxyflavone promotes the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of CYP11B1 mRNA]increases expression|increases reaction 16396990
C509288 3',4'-dimethoxyflavone 3',4'-dimethoxyflavone results in increased expression of CYP11B1 mRNAincreases expression 16396990
D000324 Adrenocorticotropic Hormone Adrenocorticotropic Hormone results in increased expression of CYP11B1 mRNAincreases expression 16410306
D000735 Androstenedione CYP11B1 protein results in increased hydroxylation of Androstenedioneincreases hydroxylation 12153581
C061004 benidipine benidipine inhibits the reaction [AGT protein results in increased expression of CYP11B1 mRNA]decreases reaction|increases expression 18331727
C061004 benidipine benidipine inhibits the reaction [Potassium Chloride results in increased expression of CYP11B1 mRNA]decreases reaction|increases expression 18331727
D003345 Corticosterone CYP11B1 protein results in increased chemical synthesis of Corticosteroneincreases chemical synthesis 16054388
D003345 Corticosterone CYP11B1 protein affects the chemical synthesis of Corticosteroneaffects chemical synthesis 11196410
D003350 Cortodoxone CYP11B1 protein affects the metabolism of Cortodoxoneaffects metabolic processing 16030167
16054388
15780661
15522937
15985365
D004997 Ethinyl Estradiol Ethinyl Estradiol results in decreased expression of CYP11B1 mRNAdecreases expression 15858796
D017316 Fadrozole Fadrozole results in decreased activity of CYP11B1 proteindecreases activity 15771425
15985365
15743198
D005576 Forskolin Forskolin results in increased activity of CYP11B1 proteinincreases activity 12525251
D005576 Forskolin Forskolin results in increased expression of CYP11B1 mRNAincreases expression 17080404
D005576 Forskolin Lindane inhibits the reaction [Forskolin results in increased expression of CYP11B1 mRNA]decreases reaction|increases expression 17080404
D006854 Hydrocortisone CYP11B1 protein affects the metabolism of Hydrocortisoneaffects metabolic processing 16030167
D006854 Hydrocortisone CYP11B1 protein results in increased chemical synthesis of Hydrocortisoneincreases chemical synthesis 16054388
D003900 Desoxycorticosterone CYP11B1 protein affects the metabolism of Desoxycorticosteroneaffects metabolic processing 16054388
D003900 Desoxycorticosterone CYP11B1 protein affects the metabolism of Desoxycorticosteroneaffects metabolic processing 11196410
D003900 Desoxycorticosterone Plant Extracts inhibits the reaction [Desoxycorticosterone binds to CYP11B1 protein]affects binding|decreases reaction 15666820
D007189 Indans Indans results in decreased activity of CYP11B1 proteindecreases activity 15743198
D007654 Ketoconazole Ketoconazole results in decreased activity of CYP11B1 proteindecreases activity 15771425
D007654 Ketoconazole Ketoconazole results in decreased activity of CYP11B1 proteindecreases activity 15743198
D001556 Lindane Lindane inhibits the reaction [Forskolin results in increased expression of CYP11B1 mRNA]decreases reaction|increases expression 17080404
D008797 Metyrapone Metyrapone results in increased expression of CYP11B1 proteinincreases expression 9832454
D010936 Plant Extracts Plant Extracts inhibits the reaction [Desoxycorticosterone binds to CYP11B1 protein]affects binding|decreases reaction 15666820
D010936 Plant Extracts Plant Extracts results in decreased activity of CYP11B1 proteindecreases activity 12766951
D011189 Potassium Chloride benidipine inhibits the reaction [Potassium Chloride results in increased expression of CYP11B1 mRNA]decreases reaction|increases expression 18331727
D011189 Potassium Chloride Potassium Chloride results in increased expression of CYP11B1 mRNAincreases expression 18331727
C045362 prochloraz prochloraz results in decreased expression of CYP11B1 mRNAdecreases expression 19733639
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of CYP11B1 mRNAdecreases expression 16254025
D013764 Tetrahydronaphthalenes Tetrahydronaphthalenes results in decreased activity of CYP11B1 proteindecreases activity 15743198
C017953 tetramethylpyrazine tetramethylpyrazine results in increased expression of CYP11B1 mRNAincreases expression 15520497
D014050 Toluene Toluene affects the expression of CYP11B1 mRNAaffects expression 18653662
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.5315322242 11752688 14514962
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.6117505938
MESH:D058186 Acute Kidney Injury Desoxycorticosterone 5.1419564549
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.7314692618
MESH:D018248 Adenoma, Liver Cell 3,4,5,3',4'-pentachlorobiphenyl 9.4616628245
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 9.4616835633
MESH:D000382 Agricultural Workers' Diseases Lindane 4.0512661182
MESH:D000544 Alzheimer Disease Plant Extracts 2.9416962711
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.6711748828
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.1511256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 6.8615885639
MESH:D001169 Arthritis, Experimental Plant Extracts 6.8614686799
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 2.7612125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.4615340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.5615746008
MESH:D002545 Brain Ischemia Plant Extracts 4.4016041641
MESH:D001943 Breast Neoplasms Lindane 2.4014688026
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.4020435547
MESH:D002057 Burns, Chemical Plant Extracts 5.009625245
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.5516835633
MESH:D006528 Carcinoma, Hepatocellular Plant Extracts 2.7218834353
MESH:D006332 Cardiomegaly Desoxycorticosterone 10.6719564549
MESH:D006332 Cardiomegaly Plant Extracts 10.6717645561
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 10.6716120746 18670907 18850075
MESH:D002547 Cerebral Palsy Toluene 5.529294310
MESH:D002659 Child Development Disorders, Pervasive Androstenedione 4.4721398041
MESH:D018281 Cholangiocarcinoma 3,4,5,3',4'-pentachlorobiphenyl 8.9116628245
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 8.9116835633
MESH:D002779 Cholestasis Ethinyl Estradiol 2.6417110522 16919318 15861022 17681005 11677210 16105132 17333356
MESH:D002972 Cleft Palate Hydrocortisone 5.8415826874
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 5.8415668235 15340226 12621046 8697196 16354765
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.7914669216 17141729
MESH:C535978 Congenital adrenal hyperplasia due to 11-Beta-hydroxylase deficiency marker/mechanism
MESH:D019465 Craniofacial Abnormalities 3,4,5,3',4'-pentachlorobiphenyl 5.2517686920
MESH:D019465 Craniofacial Abnormalities Hydrocortisone 5.2517728286
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 5.2510048152 15322242 20055451
MESH:D019465 Craniofacial Abnormalities Toluene 5.259294310
MESH:D003643 Death Toluene 5.346431079
MESH:D002658 Developmental Disabilities 2,3,3',4,4',5-hexachlorobiphenyl 5.2019647017
MESH:D003924 Diabetes Mellitus, Type 2 benidipine 4.7016387788
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.7017107852
MESH:D003928 Diabetic Nephropathies Plant Extracts 4.1419706694
MESH:D003967 Diarrhea Hydrocortisone 4.427237001
MESH:D056486 Drug-Induced Liver Injury Ketoconazole 3.9118289764
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 3.9120420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.5211462148
MESH:D004487 Edema Plant Extracts 6.0812787963
MESH:D004487 Edema Tetrachlorodibenzodioxin 6.0811000095 12711302
MESH:D004489 Edema, Cardiac 3,4,5,3',4'-pentachlorobiphenyl 11.3117686920
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 11.3115322242 18230668 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 2.8812538720
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.7410568697 9294722
MESH:D004719 Endomyocardial Fibrosis Plant Extracts 5.3515268973
MESH:D004827 Epilepsy Plant Extracts 3.5619439326 19700373
MESH:D004938 Esophageal Neoplasms 3',4'-dimethoxyflavone 4.6516530937
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.7711564622
MESH:D005234 Fatty Liver Ethinyl Estradiol 7.0815345470
MESH:D005234 Fatty Liver Plant Extracts 7.0815975614
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.1411858732
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 2.6320067830
OMIM:103900 GLUCOCORTICOID-REMEDIABLE ALDOSTERONISM marker/mechanism 1472060 1731223
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.2610696789
MESH:D006330 Heart Defects, Congenital 3,4,3',4'-tetrachlorobiphenyl 10.5211294989
MESH:D006330 Heart Defects, Congenital 3,4,5,3',4'-pentachlorobiphenyl 10.5220471113 17686920
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 10.5211294989 10048152
MESH:D006333 Heart Failure Plant Extracts 3.6718097624
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.0511000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 2.5815340226 16120746 12621046
MESH:D006561 Herpes Simplex Plant Extracts 4.3010715843
MESH:D015658 HIV Infections Plant Extracts 3.5112878215
MESH:D019584 Hot Flashes Plant Extracts 4.4216566672 17454163 14716179
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.7116959395 15340226 16354765 8697196 18606429
MESH:D020138 Hyperhomocysteinemia Plant Extracts 4.1916484555
MESH:D006949 Hyperlipidemias Plant Extracts 4.1715268973 15975614
MESH:D006973 Hypertension Desoxycorticosterone 5.3919564549 11507004
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.3918850075 18670907
MESH:D007021 Hypospadias Ethinyl Estradiol 3.4916945680 16569931
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.1612013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.2717937319
MESH:D007249 Inflammation Plant Extracts 4.6712787963 16366677 19332304 15997105
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 4.6712878042 12200463
MESH:D007414 Intestinal Neoplasms Plant Extracts 4.3412584176 12351151 12628509
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.0516580747
MESH:D007673 Kidney Cortex Necrosis tetramethylpyrazine 6.3818842672
MESH:D016773 Leishmaniasis, Cutaneous Ketoconazole 4.431311351 8889330 19744259 2166429
MESH:D007898 Leishmaniasis, Visceral Ketoconazole 4.3011332679
MESH:D008064 Lipidoses Ketoconazole 4.3417567588
MESH:D008103 Liver Cirrhosis Plant Extracts 3.5617157831
MESH:D008106 Liver Cirrhosis, Experimental Plant Extracts 2.5215479170
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.5212878042
MESH:D008107 Liver Diseases Lindane 4.481715830
MESH:D008107 Liver Diseases Plant Extracts 4.4817034775
MESH:D008113 Liver Neoplasms Plant Extracts 4.3219168119
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 4.3216984957
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 1.9112151625
MESH:D008175 Lung Neoplasms Plant Extracts 2.4920869020
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 2.4919555203 11884234
MESH:D008325 Mammary Neoplasms, Experimental Corticosterone 3.4312807724
MESH:D008607 Mental Retardation Toluene 3.549294310
MESH:D019957 Motor Skills Disorders Toluene 4.939294310
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.7612213967
MESH:D009369 Neoplasms Lindane 3.2216818664 12807735
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 2.9114600291
MESH:D019954 Neurobehavioral Manifestations 2,3,3',4,4',5-hexachlorobiphenyl 11.6519647017
MESH:D019954 Neurobehavioral Manifestations Plant Extracts 11.6517168769
MESH:D009765 Obesity Plant Extracts 3.0620132043 19056576
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.3911578682
MESH:D010212 Papilloma Plant Extracts 4.1816517061 15173996
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 3.9212520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.2518163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 2.8711222880 11118676 11399792 11896295
MESH:D011471 Prostatic Neoplasms Ketoconazole 3.0917404083
MESH:D011471 Prostatic Neoplasms Lindane 3.0914688026 12661182
MESH:D011471 Prostatic Neoplasms Plant Extracts 3.0917804756 14666653
MESH:D011537 Pruritus Ethinyl Estradiol 2.9916919318 15861022
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.5318990726
MESH:D012640 Seizures Lindane 5.9815475178 7539098 12842176
MESH:D012640 Seizures Toluene 5.989294310 6431079
MESH:D012878 Skin Neoplasms Plant Extracts 5.3615173996 16517061
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.3616192470
MESH:D013088 Spermatocele Ethinyl Estradiol 3.6116709447
MESH:D013276 Stomach Ulcer Plant Extracts 3.6112787963 17135157 18193104 18237397 15255614
MESH:D013705 Temporomandibular Joint Disorders Plant Extracts 5.1517997062
MESH:D013733 Testicular Diseases Toluene 4.6310514026 10048760
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.3211994571
MESH:D013927 Thrombosis Ethinyl Estradiol 2.8815669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.5712697716
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 2.9914692618
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.2612125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.2514671159 15869587
MESH:D018487 Ventricular Dysfunction, Left Plant Extracts 4.4318097624
MESH:D020257 Ventricular Remodeling Plant Extracts 4.9918097624
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 3.9215886252
MESH:D014947 Wounds and Injuries Plant Extracts 3.9920213670 19894650
Pathway ID Pathway Name
REACT:13433 Biological oxidations
REACT:15314 Hormone biosynthesis
KEGG:01100 Metabolic pathways
REACT:22258 Metabolism of lipids and lipoproteins
KEGG:00140 Steroid hormone biosynthesis
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA133
    • No data
    Releated disease ID Related disease Name
    PA443796Coronary Artery Disease
    Releated drug ID Related drug Name
    PA164712308Ace Inhibitors, Plain
    PA450877perindopril
    PA449512estrone
    PA451123progesterone
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB00648 agonist Mitotane Antineoplastic Agents;Antineoplastic Agents, Hormonal
    DB01011 antagonist Metyrapone Antimetabolites;Enzyme Inhibitors
    Drugbank ID Action Drug Name Description
    DB00196 inhibitor Fluconazole Antifungals;Antifungal Agents
    DB00252 inhibitor Dilantin W Phenobarbital 30mg Cap Anticonvulsants
    DB00257 inhibitor Lotrisone Antifungal Agents;Anti-Infective Agents, Local;Growth Inhibitors
    DB00292 inhibitor Etomidate Hypnotics and Sedatives;Anesthetics, Intravenous
    DB00421 inducer Novo-Spirozine-50 Tab Diuretics;Aldosterone Antagonists
    DB00501 inhibitor Cimetidine Anti-Ulcer Agents;Analgesics;Enzyme Inhibitors;Adjuvants;Histamine Antagonists;Histamine H2 Antagonists
    DB00741 substrate Vosol Hc Anti-inflammatory Agents
    DB01011 inhibitor Metyrapone Antimetabolites;Enzyme Inhibitors
    DB01026 inhibitor Ketoconazole Antifungals;Antifungal Agents
    DB01110 inhibitor Miconazole Antifungal Agents
    DB01233 inhibitor Metoclopramide Antiemetics;Dopamine Antagonists;Prokinetic Agents
    DB01388 inhibitor Mibefradil Antihypertensive Agents;Vasodilator Agents;Calcium Channel Blockers
    DB04630 substrate Aldosterone
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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