AutismKB 2.0

Annotation Detail for PRUNE2


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Basic Information Top
Gene Symbol:PRUNE2 ( A214N16.3,BMCC1,BNIPXL,C9orf65,DKFZp762K117,FLJ50060,FLJ54876,FLJ59118,KIAA0367,RP11-58J3.2,bA214N16.3 )
Gene Full Name: prune homolog 2 (Drosophila)
Band: 9q21.2
Quick LinksEntrez ID:158471; OMIM: 610691; Uniprot ID:PRUN2_HUMAN; ENSEMBL ID: ENSG00000106772; HGNC ID: 25209
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
No data
Desease Name
NEUROLOGICAL
hippocampal atrophy
Desease Name
Hippocampal atrophy
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of PRUNE2 mRNAdecreases expression 20106945
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in decreased expression of PRUNE2 mRNAdecreases expression 15336504
D016572 Cyclosporine Cyclosporine results in increased expression of PRUNE2 mRNAincreases expression 20106945
D004958 Estradiol [Progesterone co-treated with Estradiol] results in increased expression of PRUNE2 mRNAaffects cotreatment|increases expression 17404688
C030589 methylmercury cysteine methylmercury cysteine results in decreased expression of PRUNE2 mRNAdecreases expression 19465457
D011374 Progesterone [Progesterone co-treated with Estradiol] results in increased expression of PRUNE2 mRNAaffects cotreatment|increases expression 17404688
C004648 testosterone enanthate testosterone enanthate affects the expression of PRUNE2 mRNAaffects expression 17440010
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of PRUNE2 mRNAdecreases expression 20106945
D014212 Tretinoin Tretinoin results in increased expression of PRUNE2 mRNAincreases expression 16288218
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.1314514962 15322242 11752688
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 4.4320127859 20464547
MESH:D000230 Adenocarcinoma Estradiol 4.4311473722
MESH:D000236 Adenoma Benzo(a)pyrene 2.766695378
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.6616835633
MESH:D000505 Alopecia Tretinoin 3.7815955085
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.1411748828
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.3319183758
MESH:D001169 Arthritis, Experimental Tretinoin 3.1916412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.3016292516
MESH:D001249 Asthma Tretinoin 2.3916456186
MESH:D001471 Barrett Esophagus Tretinoin 4.6416935849
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 9.6312125929
MESH:D001778 Blood Coagulation Disorders Tretinoin 9.6316206674 16197459
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.1115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8915746008
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 5.6617868700
MESH:D001930 Brain Injuries Progesterone 4.5215665606 15380490 15845082
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.3817474063 20146248
MESH:D001943 Breast Neoplasms Estradiol 2.3812948864 17261762 18497071 16675129 14630087 19861407 17289903 17018787
MESH:D001943 Breast Neoplasms Progesterone 2.3817614352 16175315 15562024
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.3820435547
MESH:D001943 Breast Neoplasms Tretinoin 2.3816873071 16443354 16166294
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.8816813970
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.7516111702
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.9616835633
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.4816168501
MESH:D006528 Carcinoma, Hepatocellular Estradiol 3.0916924424
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 3.091917145
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 4.7420419170
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 4.7416096774 16051514
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4716120746 18670907 18850075
MESH:D002386 Cataract Tretinoin 3.2017460283
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 7.0312371664
MESH:D002471 Cell Transformation, Neoplastic Estradiol 7.0318566989
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.8816129372
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.3416835633
MESH:D002779 Cholestasis Cyclosporine 3.0619486331
MESH:D002822 Choriocarcinoma Tretinoin 5.4816461808
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 6.0215340226 8697196 12621046 15668235 16354765
MESH:D002972 Cleft Palate Tretinoin 6.029407595
MESH:D003092 Colitis Tretinoin 3.9617035595
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.2417141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.5010048152 15322242 20055451
MESH:D019465 Craniofacial Abnormalities Tretinoin 2.509224671 17551590 9142499 16925845 14991402 10589399 9211117 9664655 9125849 8800419
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7117107852
MESH:D003928 Diabetic Nephropathies Estradiol 3.5919279558
MESH:D003929 Diabetic Neuropathies Progesterone 4.7517187935
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 1.5820420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.9111462148
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.5811000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 13.0316714409 18230668 15322242
MESH:D004489 Edema, Cardiac Tretinoin 13.0318230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 4.0217692515
MESH:D016889 Endometrial Neoplasms Estradiol 7.8411473722 18566989 19148513
MESH:D016889 Endometrial Neoplasms Tretinoin 7.8416569247
MESH:D004715 Endometriosis Progesterone 9.5816134523
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 9.5810568697 9294722
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 2.0516530937
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 9.3411564622
MESH:D005124 Eye Abnormalities Tretinoin 9.3416938888 9664655
MESH:D005234 Fatty Liver Cyclosporine 3.0619224547
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.7111858732
MESH:D005355 Fibrosis Cyclosporine 16.2912168785 12639820
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 16.2920067830
MESH:D005355 Fibrosis Tretinoin 16.2917994277
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.508708960
MESH:D005909 Glioblastoma Tretinoin 3.1317312396
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.9110696789
MESH:D006258 Head and Neck Neoplasms Tretinoin 3.3216096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.4816084493
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 11.6620471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 11.6610048152 11294989
MESH:D006330 Heart Defects, Congenital Tretinoin 11.6614991402 9664655
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.7115720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.5411000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.1516120746 12621046 15340226
MESH:D006558 Herpes Genitalis Estradiol 5.3515709030
MESH:D019247 HIV Wasting Syndrome testosterone enanthate 6.0617440010
MESH:D019584 Hot Flashes Estradiol 4.0717088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.368697196 16959395 16354765 15340226 18606429
MESH:D006930 Hyperalgesia Tretinoin 3.3716870215
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.8316778211
MESH:D006973 Hypertension Cyclosporine 5.1710903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.1718850075 18670907
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 4.6615869954
MESH:D007249 Inflammation Progesterone 5.3015869954
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 5.3012200463 12878042
MESH:D007333 Insulin Resistance Estradiol 3.0916627594 16393666
MESH:D007410 Intestinal Diseases Tretinoin 4.0217994277
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 10.6316580747
MESH:D007569 Jaw Abnormalities Tretinoin 10.6315992940 17551590
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.7615604871
MESH:D007674 Kidney Diseases Cyclosporine 6.308314463 10903974 18776723
MESH:D007674 Kidney Diseases Estradiol 6.3015618244
MESH:D007680 Kidney Neoplasms Cyclosporine 7.8512371664
MESH:D007680 Kidney Neoplasms Estradiol 7.8515610895
MESH:D007938 Leukemia Tretinoin 2.8617143497
MESH:D007951 Leukemia, Myeloid Tretinoin 3.9016482212 16932348 19285840
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 2.1016294345 19850784 17596541
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 3.2817107899 17217047 16891316 19075265 17294898 19225113 17339181 19029980 17361223 17301526 9834237 16766008 19035177 17506722 19642359 16331271 17649720 17368321 16140955 15748426 17712046 16788101 16823087 16935935 12679006
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.459224671
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 3.5514716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.5512878042
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 3.5516248980 18397230
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 4.5520195826 21137059
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 4.5516984957
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 2.2212151625
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 2.2320869020 20464547 20135361 18816296 18520028 18569708 6695378 20064080 17053015
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 2.2319555203 11884234
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 6.4811807958 11408345 17203775 16891317
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 6.4817203775 11408345
MESH:D020149 Manganese Poisoning Estradiol 4.8019453300
MESH:D008527 Medulloblastoma Tretinoin 2.8517453147
MESH:D008545 Melanoma Tretinoin 1.9616752155
MESH:D008591 Meningomyelocele Tretinoin 4.6816940565
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.1116801185
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.3516381670
MESH:D009190 Myelodysplastic Syndromes Tretinoin 3.1917596541
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.1812213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 3.4416810080
MESH:D009369 Neoplasms Benzo(a)pyrene 5.2911141357
MESH:D009369 Neoplasms Tretinoin 5.2916594593 16946489
MESH:D009389 Neovascularization, Pathologic Estradiol 4.0217289903
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.7617954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.4719348381 18481113
MESH:D009421 Nervous System Malformations Estradiol 17.7811399458 16427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 17.7814600291
MESH:D009421 Nervous System Malformations Tretinoin 17.789125849
MESH:D009436 Neural Tube Defects Tretinoin 3.189142499
MESH:D010051 Ovarian Neoplasms Estradiol 8.2119401270
MESH:D010051 Ovarian Neoplasms Progesterone 8.2117393432 16525653
MESH:D010051 Ovarian Neoplasms Tretinoin 8.2116936753
MESH:D010146 Pain Tretinoin 3.0716870215
MESH:D010190 Pancreatic Neoplasms Tretinoin 2.5215976015
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.5712520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.8018163543
MESH:D011230 Precancerous Conditions Cyclosporine 3.4012371664
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.4811896295 11399792 11118676 11222880
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 4.0920887781
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 3.0617292933
MESH:D011471 Prostatic Neoplasms Estradiol 3.0616740699
MESH:D011507 Proteinuria Tretinoin 3.8216636307
MESH:D011565 Psoriasis Cyclosporine 2.2916882103
MESH:D011625 Pterygium Tretinoin 5.0816723453
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.0818990726
MESH:D012208 Rhabdomyosarcoma Tretinoin 4.3216283617 16116481
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.9118045962
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 14.2710029692 19755658
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 14.278532709
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 14.2716192470
MESH:D012878 Skin Neoplasms Tretinoin 14.2716467112
MESH:D013119 Spinal Cord Injuries Progesterone 4.5615862959 16503802
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 2.3920155912 2093021
MESH:D013274 Stomach Neoplasms Tretinoin 2.3917261132
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.2212697716
MESH:D013964 Thyroid Neoplasms Tretinoin 3.1816026305 17045167
MESH:D013978 Tibial Fractures Estradiol 5.0019048282
MESH:D014062 Tongue Neoplasms Tretinoin 3.9816051514
MESH:D014376 Tuberculosis Tretinoin 3.3416040207
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 2.2417053015
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 3.8716129372
MESH:D014604 Uveal Neoplasms Tretinoin 4.9316752155
MESH:D014605 Uveitis Cyclosporine 4.301336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.9112125929
MESH:D014820 Vitiligo Tretinoin 4.2916761959
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.5715886252
MESH:D009396 Wilms Tumor Tretinoin 4.1516287080
MESH:D014985 Xerophthalmia Cyclosporine 4.7617120751
Pathway ID Pathway Name
KEGG:00230 Purine metabolism
Pharmacogenomics Knowledge Base Top
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Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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