AutismKB 2.0

Annotation Detail for CYP17A1


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Basic Information Top
Gene Symbol:CYP17A1 ( CPT7,CYP17,P450C17,S17AH )
Gene Full Name: cytochrome P450, family 17, subfamily A, polypeptide 1
Band: 10q24.32
Quick LinksEntrez ID:1586; OMIM: 609300; Uniprot ID:CP17A_HUMAN; ENSEMBL ID: ENSG00000148795; HGNC ID: 2593
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Pathway IDPathway Name
PWY66-381glucocorticoid biosynthesis
PWY66-378androgen biosynthesis
Pathway IDPathway Name
hsa00140Steroid hormone biosynthesis
hsa01100Metabolic pathways
Pathway IDPathway Name
Hormone biosynthesis
Metabolism of lipids and lipoproteins
Biological oxidations
No data
No data
Pathway IDPathway Name
500195Endogenous sterols
500772Steroid hormones
500776Androgen biosynthesis
500774Glucocorticoid biosynthesis
500832Metabolism of steroid hormones and vitamin D
Related Diseases/Disorders Top
Desease IDDesease Name
Inherited disorders of lipid/glycolipid metabolism
H00216Congenital adrenal hyperplasia
Genetic disorders
No data
Desease Name
rheumatoid arthritis
ovarian cancer
oral cancer
Parkinson's disease
polycystic ovary syndrome
menarche
colorectal cancer
prostate cancer prostate specific antigen
CARDIOVASCULAR
height
urinary calculus
endometriosis
serum androgen concentrations
Osteoporosis
menopause
hormone disturbance
bone size
prostate cancer
male breast cancer
prostatic hyperplasia
Bone Mineral Density
CANCER
liver disease
systolic blood pressure
Osteoporosis, Postmenopausal
intrauterine growth
serum estrogen and progesterone concentrations
bone density
endometrial cancer
Polycystic ovaries and premature male pattern baldness
breast cancer
Lymphoma, Non-Hodgkin
IMMUNE
NEUROLOGICAL
pregnancy loss, recurrent
METABOLIC
spondyloarthropathies
Body Weight
stature
acne
sex hormones
REPRODUCTION
INFECTION
Overweight
prostate volume/histology endocrine patterns
testosterone
Insulin Resistance
Desease Name
Parkinson's disease
Systolic blood pressure
Desease Name
17-alpha-hydroxylase/17,20-lyase deficiency
17,20-lyase deficiency, isolated
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C003582 11-hydroxyandrostenedione 11-hydroxyandrostenedione results in decreased expression of CYP17A1 mRNAdecreases expression 15858796
C483839 2,2',3,4,4',5',6-heptabromodiphenyl ether 2,2',3,4,4',5',6-heptabromodiphenyl ether results in decreased activity of CYP17A1 proteindecreases activity 16828825
C404910 2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane 2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane results in decreased expression of CYP17A1 mRNAdecreases expression 11509743
C404910 2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane [Estradiol co-treated with 2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane] results in decreased expression of CYP17A1 mRNAaffects cotreatment|decreases expression 11509743
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of CYP17A1 mRNAaffects expression 21346803
C023035 3,4,5,3',4'-pentachlorobiphenyl 3,4,5,3',4'-pentachlorobiphenyl results in decreased activity of CYP17A1 proteindecreases activity 15703266
C023035 3,4,5,3',4'-pentachlorobiphenyl 3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of CYP17A1 mRNAdecreases expression 15703266
C023035 3,4,5,3',4'-pentachlorobiphenyl 3,4,5,3',4'-pentachlorobiphenyl results in increased expression of CYP17A1 mRNAincreases expression 16216300
C023035 3,4,5,3',4'-pentachlorobiphenyl 3,4,5,3',4'-pentachlorobiphenyl results in increased expression of CYP17A1 mRNAincreases expression 12781204
C439677 3-hydroxy-17-(1H-1,2,3-triazol-1-yl)androsta-5,16-diene 3-hydroxy-17-(1H-1,2,3-triazol-1-yl)androsta-5,16-diene results in decreased activity of CYP17A1 proteindecreases activity 15555909
C500627 3-hydroxy-17-(1H-benzimidazole-1-yl)androsta-5,16-diene 3-hydroxy-17-(1H-benzimidazole-1-yl)androsta-5,16-diene results in decreased activity of CYP17A1 proteindecreases activity 15828836
C495960 3-hydroxy-17-(imidazol-1-yl)androsta-5,16-diene 3-hydroxy-17-(imidazol-1-yl)androsta-5,16-diene results in decreased activity of CYP17A1 proteindecreases activity 15555909
C494060 4-nitro-3-phenylphenol [4-nitro-3-phenylphenol co-treated with 8-Bromo Cyclic Adenosine Monophosphate] results in decreased expression of CYP17A1 proteinaffects cotreatment|decreases expression 18336853
D000082 Acetaminophen Acetaminophen affects the expression of CYP17A1 mRNAaffects expression 17562736
D000082 Acetaminophen Acetaminophen results in decreased expression of CYP17A1 mRNAdecreases expression 17202762
D000324 Adrenocorticotropic Hormone Adrenocorticotropic Hormone results in increased expression of CYP17A1 mRNAincreases expression 15625562
D043582 5-alpha-Dihydroprogesterone CYP17A1 protein results in increased hydroxylation of 5-alpha-Dihydroprogesteroneincreases hydroxylation 14522586
D006907 17-alpha-Hydroxypregnenolone CYP17A1 protein affects the chemical synthesis of 17-alpha-Hydroxypregnenoloneaffects chemical synthesis 16030167
D006907 17-alpha-Hydroxypregnenolone CYP17A1 protein affects the metabolism of 17-alpha-Hydroxypregnenoloneaffects metabolic processing 16030167
D006907 17-alpha-Hydroxypregnenolone CYP17A1 protein results in decreased acetylation of 17-alpha-Hydroxypregnenolonedecreases acetylation 15562394
D000643 Ammonium Chloride Ammonium Chloride affects the expression of CYP17A1 mRNAaffects expression 16483693
D000728 Androgens CYP17A1 protein affects the chemical synthesis of Androgensaffects chemical synthesis 15761033
D000728 Androgens CYP17A1 protein affects the chemical synthesis of Androgensaffects chemical synthesis 14624484
D000728 Androgens CYP17A1 protein affects the chemical synthesis of Androgensaffects chemical synthesis 15862817
C000152 androsta-5,16-dien-3 beta-ol CYP17A1 protein affects the chemical synthesis of androsta-5,16-dien-3 beta-olaffects chemical synthesis 12631293
C000152 androsta-5,16-dien-3 beta-ol CYP17A1 protein affects the chemical synthesis of androsta-5,16-dien-3 beta-olaffects chemical synthesis 12631293
D000735 Androstenedione Androstenedione results in decreased expression of CYP17A1 mRNAdecreases expression 15625562
D000735 Androstenedione Androstenedione results in decreased expression of CYP17A1 mRNAdecreases expression 15625562
D000735 Androstenedione CYP17A1 protein affects the chemical synthesis of Androstenedioneaffects chemical synthesis 14522586
16030167
15562394
D000735 Androstenedione TNF protein inhibits the reaction [CYP17A1 protein affects the chemical synthesis of Androstenedione]affects chemical synthesis|decreases reaction 16030167
D000735 Androstenedione CYP17A1 protein affects the chemical synthesis of Androstenedioneaffects chemical synthesis 15555913
D000735 Androstenedione CYP17A1 protein affects the chemical synthesis of Androstenedioneaffects chemical synthesis 15640159
D000738 Androsterone CYP17A1 protein affects the chemical synthesis of Androsteroneaffects chemical synthesis 14522586
C103016 antalarmin antalarmin results in decreased expression of CYP17A1 mRNAdecreases expression 16014403
C432165 anthra(1,9-cd)pyrazol-6(2H)-one anthra(1,9-cd)pyrazol-6(2H)-one inhibits the reaction [FGF19 protein results in decreased expression of CYP17A1 mRNA]decreases expression|decreases reaction 16269825
C432165 anthra(1,9-cd)pyrazol-6(2H)-one anthra(1,9-cd)pyrazol-6(2H)-one results in increased expression of CYP17A1 mRNAincreases expression 16269825
D001151 Arsenic CYP17A1 protein affects the metabolism of Arsenicaffects metabolic processing 18682255
C006632 arsenic trioxide arsenic trioxide results in decreased expression of CYP17A1 mRNAdecreases expression 18630931
C104416 astressin astressin results in decreased expression of CYP17A1 mRNAdecreases expression 16014403
C006780 bisphenol A bisphenol A results in increased expression of CYP17A1 mRNAincreases expression 17706920
C006780 bisphenol A bisphenol A results in decreased expression of CYP17A1 mRNAdecreases expression 20144698
15901920
C006780 bisphenol A bisphenol A results in decreased expression of CYP17A1 proteindecreases expression 20144698
14605012
C006780 bisphenol A [bisphenol A results in decreased expression of CYP17A1 protein] which results in decreased abundance of Testosteronedecreases abundance|decreases expression 14605012
C006780 bisphenol A bisphenol A results in increased expression of CYP17A1 mRNAincreases expression 18191889
C006780 bisphenol A [bisphenol A results in increased expression of CYP17A1 mRNA] which affects the abundance of Testosteroneaffects abundance|increases expression 18191889
D015124 8-Bromo Cyclic Adenosine Monophosphate [4-nitro-3-phenylphenol co-treated with 8-Bromo Cyclic Adenosine Monophosphate] results in decreased expression of CYP17A1 proteinaffects cotreatment|decreases expression 18336853
D002220 Carbamazepine Carbamazepine results in decreased activity of CYP17A1 proteindecreases activity 15730543
D002220 Carbamazepine Carbamazepine results in decreased expression of CYP17A1 mRNAdecreases expression 19566492
D002784 Cholesterol CYP17A1 protein affects the chemical synthesis of Cholesterolaffects chemical synthesis 15761033
C029010 cinnamic acid cinnamic acid analog results in decreased activity of CYP17A1 proteindecreases activity 15072549
D002995 Clofibric Acid [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of CYP17A1 mRNAaffects cotreatment|affects expression 17602206
D003314 Corn Oil Corn Oil affects the expression of CYP17A1 mRNAaffects expression 16360708
C010902 decabromobiphenyl ether decabromobiphenyl ether results in decreased activity of CYP17A1 proteindecreases activity 18495385
D003687 Dehydroepiandrosterone Dehydroepiandrosterone results in decreased expression of CYP17A1 mRNAdecreases expression 15625562
D003687 Dehydroepiandrosterone CYP17A1 protein affects the chemical synthesis of Dehydroepiandrosteroneaffects chemical synthesis 16030167
15562394
D003687 Dehydroepiandrosterone Dehydroepiandrosterone results in decreased expression of CYP17A1 mRNAdecreases expression 15625562
D003687 Dehydroepiandrosterone CYP17A1 protein affects the chemical synthesis of Dehydroepiandrosteroneaffects chemical synthesis 15666818
D003687 Dehydroepiandrosterone CYP17A1 protein affects the chemical synthesis of Dehydroepiandrosteroneaffects chemical synthesis 15934942
D003687 Dehydroepiandrosterone CYP17A1 protein affects the metabolism of Dehydroepiandrosteroneaffects metabolic processing 15261307
D003687 Dehydroepiandrosterone CYP17A1 protein affects the chemical synthesis of Dehydroepiandrosteroneaffects chemical synthesis 15640159
D003993 Dibutyl Phthalate Dibutyl Phthalate results in decreased expression of CYP17A1 mRNAdecreases expression 15987825
15141095
14617579
D003993 Dibutyl Phthalate Dibutyl Phthalate results in decreased expression of CYP17A1 proteindecreases expression 14617579
15141095
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of CYP17A1 mRNAaffects cotreatment|affects expression 17602206
D004054 Diethylstilbestrol Diethylstilbestrol affects the expression of CYP17A1 mRNAaffects expression 15196701
D004054 Diethylstilbestrol Diethylstilbestrol affects the expression of CYP17A1 proteinaffects expression 15196701
D004128 Dimethylnitrosamine Dimethylnitrosamine results in decreased expression of CYP17A1 mRNAdecreases expression 17072980
C035144 drospirenone [Ethinyl Estradiol co-treated with drospirenone] results in decreased activity of CYP17A1 proteinaffects cotreatment|decreases activity 17418832
D004958 Estradiol ESR1 protein affects the reaction [Estradiol results in decreased expression of CYP17A1 mRNA]affects reaction|decreases expression 17158782
D004958 Estradiol [Estradiol co-treated with 2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane] results in decreased expression of CYP17A1 mRNAaffects cotreatment|decreases expression 11509743
D004958 Estradiol [Estradiol co-treated with Methoxychlor metabolite] results in decreased expression of CYP17A1 mRNAaffects cotreatment|decreases expression 11509743
D004958 Estradiol Estradiol results in decreased expression of CYP17A1 mRNAdecreases expression 11509743
17158782
D004958 Estradiol Estradiol results in decreased expression of CYP17A1 mRNAdecreases expression 20144698
D004958 Estradiol Estradiol results in decreased expression of CYP17A1 proteindecreases expression 20144698
D004967 Estrogens CYP17A1 promoter polymorphism affects the metabolism of Estrogensaffects metabolic processing 16850246
D004967 Estrogens CYP17A1 protein affects the chemical synthesis of Estrogensaffects chemical synthesis 15341023
D002393 Estrogens, Catechol CYP17A1 protein polymorphism results in increased chemical synthesis of Estrogens, Catecholincreases chemical synthesis 15288375
D004997 Ethinyl Estradiol [Ethinyl Estradiol co-treated with drospirenone] results in decreased activity of CYP17A1 proteinaffects cotreatment|decreases activity 17418832
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of CYP17A1 mRNAaffects expression 14976129
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of CYP17A1 mRNAincreases expression 12072388
D004997 Ethinyl Estradiol Ethinyl Estradiol results in decreased expression of CYP17A1 mRNAdecreases expression 15858796
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of CYP17A1 mRNAaffects expression 17222921
D004997 Ethinyl Estradiol Ethinyl Estradiol results in decreased expression of CYP17A1 mRNAdecreases expression 12655037
16140622
15901920
15834898
C026098 etiracetam etiracetam results in decreased expression of CYP17A1 mRNAdecreases expression 19566492
D017316 Fadrozole Fadrozole results in decreased activity of CYP17A1 proteindecreases activity 15771425
15743198
D005485 Flutamide Flutamide results in increased expression of CYP17A1 mRNAincreases expression 11509743
D005485 Flutamide Flutamide affects the expression of CYP17A1 mRNAaffects expression 17222921
D005485 Flutamide Flutamide results in increased expression of CYP17A1 mRNAincreases expression 14967917
D005576 Forskolin Forskolin results in increased expression of CYP17A1 mRNAincreases expression 15625562
D005576 Forskolin Forskolin results in increased expression of CYP17A1 mRNAincreases expression 15625562
15886251
17080404
D005576 Forskolin Lindane inhibits the reaction [Forskolin results in increased expression of CYP17A1 mRNA]decreases reaction|increases expression 17080404
D005576 Forskolin TGFB1 protein inhibits the reaction [Forskolin results in increased expression of CYP17A1 mRNA]decreases reaction|increases expression 15625562
D005576 Forskolin AGT protein inhibits the reaction [Forskolin results in increased expression of CYP17A1 protein]decreases reaction|increases expression 15666819
D005576 Forskolin Forskolin results in increased expression of CYP17A1 proteinincreases expression 15666819
D005576 Forskolin Tetradecanoylphorbol Acetate inhibits the reaction [Forskolin results in increased expression of CYP17A1 protein]decreases reaction|increases expression 15666819
D005576 Forskolin AGT protein inhibits the reaction [Forskolin results in increased expression of CYP17A1 protein]decreases reaction|increases expression 15666819
D005576 Forskolin Forskolin results in increased expression of CYP17A1 proteinincreases expression 15666819
D005576 Forskolin Tetradecanoylphorbol Acetate inhibits the reaction [Forskolin results in increased expression of CYP17A1 protein]decreases reaction|increases expression 15666819
C070081 fulvestrant fulvestrant results in increased expression of CYP17A1 mRNAincreases expression 17158782
C056933 fumonisin B1 fumonisin B1 results in decreased expression of CYP17A1 mRNAdecreases expression 16221962
C001277 geldanamycin geldanamycin results in increased expression of CYP17A1 mRNAincreases expression 15711029
D019833 Genistein Genistein results in decreased expression of CYP17A1 mRNAdecreases expression 15901920
D012739 Gonadal Steroid Hormones CYP17A1 protein affects the chemical synthesis of Gonadal Steroid Hormonesaffects chemical synthesis 16045239
D006064 Gonadotropins, Equine Gonadotropins, Equine inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of CYP17A1 mRNA]decreases expression|decreases reaction 19276399
D055768 Halogenated Diphenyl Ethers Halogenated Diphenyl Ethers metabolite results in decreased expression of CYP17A1 mRNAdecreases expression 18313098
D055768 Halogenated Diphenyl Ethers Halogenated Diphenyl Ethers metabolite results in increased expression of CYP17A1 mRNAincreases expression 18313098
D006063 Chorionic Gonadotropin Chorionic Gonadotropin results in increased expression of CYP17A1 mRNAincreases expression 15930178
C029424 hydrazine hydrazine results in increased expression of CYP17A1 mRNAincreases expression 15370871
D019326 17-alpha-Hydroxyprogesterone CYP17A1 protein affects the chemical synthesis of 17-alpha-Hydroxyprogesteroneaffects chemical synthesis 16030167
D019326 17-alpha-Hydroxyprogesterone CYP17A1 protein affects the metabolism of 17-alpha-Hydroxyprogesteroneaffects metabolic processing 16030167
D019326 17-alpha-Hydroxyprogesterone TNF protein inhibits the reaction [CYP17A1 protein affects the metabolism of 17-alpha-Hydroxyprogesterone]affects metabolic processing|decreases reaction 16030167
D006908 Hydroxyprogesterones CYP17A1 protein results in decreased acetylation of Hydroxyprogesteronesdecreases acetylation 15562394
D007189 Indans Indans results in decreased activity of CYP17A1 proteindecreases activity 15743198
D007529 Isoflavones Isoflavones results in increased activity of CYP17A1 proteinincreases activity 15698548
D007654 Ketoconazole Ketoconazole results in decreased activity of CYP17A1 proteindecreases activity 15771425
15743198
D007654 Ketoconazole Ketoconazole results in decreased activity of CYP17A1 proteindecreases activity 15934942
D007657 Ketone Bodies Ketone Bodies results in decreased expression of CYP17A1 mRNAdecreases expression 15469884
C047781 lamotrigine lamotrigine results in decreased activity of CYP17A1 proteindecreases activity 15730543
D001556 Lindane Lindane inhibits the reaction [Forskolin results in increased expression of CYP17A1 mRNA]decreases reaction|increases expression 17080404
C013598 methoxyacetic acid methoxyacetic acid results in increased expression of CYP17A1 mRNAincreases expression 18486176
D008731 Methoxychlor [Estradiol co-treated with Methoxychlor metabolite] results in decreased expression of CYP17A1 mRNAaffects cotreatment|decreases expression 11509743
D008731 Methoxychlor Methoxychlor metabolite results in decreased expression of CYP17A1 mRNAdecreases expression 11509743
D008797 Metyrapone Metyrapone results in increased expression of CYP17A1 mRNAincreases expression 15265784
C016599 mono-(2-ethylhexyl)phthalate mono-(2-ethylhexyl)phthalate results in decreased expression of CYP17A1 mRNAdecreases expression 16809437
C016599 mono-(2-ethylhexyl)phthalate mono-(2-ethylhexyl)phthalate results in increased expression of CYP17A1 mRNAincreases expression 16809437
C406082 monomethylarsonous acid monomethylarsonous acid results in decreased expression of CYP17A1 mRNAdecreases expression 20024957
D009281 Naphthalenes Naphthalenes analog results in decreased activity of CYP17A1 proteindecreases activity 15449729
C042763 olive oil olive oil analog affects the expression of CYP17A1 mRNAaffects expression 17349074
D010126 Ozone Ozone results in decreased expression of CYP17A1 mRNAdecreases expression 16183385
C093973 PD 98059 PD 98059 results in decreased expression of CYP17A1 mRNAdecreases expression 15817663
C093973 PD 98059 PD 98059 results in increased activity of CYP17A1 proteinincreases activity 17138841
C093973 PD 98059 PD 98059 results in increased expression of CYP17A1 mRNAincreases expression 17138841
C093973 PD 98059 pioglitazone inhibits the reaction [PD 98059 results in increased activity of CYP17A1 protein]decreases reaction|increases activity 17138841
C093973 PD 98059 pioglitazone inhibits the reaction [PD 98059 results in increased expression of CYP17A1 mRNA]decreases reaction|increases expression 17138841
C076994 perfluorooctane sulfonic acid perfluorooctane sulfonic acid results in increased expression of CYP17A1 mRNAincreases expression 16221955
C023036 perfluorooctanoic acid perfluorooctanoic acid results in increased expression of CYP17A1 mRNAincreases expression 17681415
C023036 perfluorooctanoic acid perfluorooctanoic acid results in increased expression of CYP17A1 mRNAincreases expression 16221955
D010634 Phenobarbital Phenobarbital results in increased expression of CYP17A1 mRNAincreases expression 19270015
C060836 pioglitazone pioglitazone inhibits the reaction [PD 98059 results in increased activity of CYP17A1 protein]decreases reaction|increases activity 17138841
C060836 pioglitazone pioglitazone inhibits the reaction [PD 98059 results in increased expression of CYP17A1 mRNA]decreases reaction|increases expression 17138841
C060836 pioglitazone pioglitazone results in decreased activity of CYP17A1 proteindecreases activity 15072549
17138841
C060836 pioglitazone pioglitazone results in decreased expression of CYP17A1 mRNAdecreases expression 17138841
C006253 pirinixic acid pirinixic acid results in increased expression of CYP17A1 mRNAincreases expression 20059764
18301758
C006253 pirinixic acid PPARA protein promotes the reaction [pirinixic acid results in increased expression of CYP17A1 mRNA]increases expression|increases reaction 20059764
D010936 Plant Extracts Plant Extracts inhibits the reaction [Pregnenolone binds to CYP17A1 protein]affects binding|decreases reaction 15666820
D011075 Polybrominated Biphenyls Polybrominated Biphenyls analog results in decreased activity of CYP17A1 proteindecreases activity 16828825
D011280 Pregnanolone CYP17A1 protein results in increased hydroxylation of Pregnanolone analogincreases hydroxylation 14522586
D011284 Pregnenolone CYP17A1 protein results in increased hydroxylation of Pregnenoloneincreases hydroxylation 15459122
D011284 Pregnenolone CYP17A1 protein affects the metabolism of Pregnenoloneaffects metabolic processing 15993106
D011284 Pregnenolone CYP17A1 protein affects the metabolism of Pregnenoloneaffects metabolic processing 16030167
16054388
D011284 Pregnenolone CYP17A1 protein mutant form results in increased hydroxylation of Pregnenoloneincreases hydroxylation 15844475
D011284 Pregnenolone CYP17A1 protein results in increased hydroxylation of Pregnenoloneincreases hydroxylation 15562394
15844475
D011284 Pregnenolone CYP17A1 protein results in increased hydroxylation of Pregnenoloneincreases hydroxylation 15459122
D011284 Pregnenolone Plant Extracts inhibits the reaction [Pregnenolone binds to CYP17A1 protein]affects binding|decreases reaction 15666820
D011284 Pregnenolone CYP17A1 protein results in increased hydroxylation of Pregnenoloneincreases hydroxylation 15640159
C045362 prochloraz prochloraz results in decreased activity of CYP17A1 proteindecreases activity 19733639
C045362 prochloraz prochloraz results in decreased expression of CYP17A1 mRNAdecreases expression 19733639
C045362 prochloraz prochloraz results in increased expression of CYP17A1 mRNAincreases expression 19767443
C045362 prochloraz prochloraz results in decreased activity of CYP17A1 proteindecreases activity 17369198
16375936
17234647
C045362 prochloraz [prochloraz results in decreased activity of CYP17A1 protein] which results in decreased chemical synthesis of Testosteronedecreases activity|decreases chemical synthesis 17369198
17234647
C045362 prochloraz prochloraz results in increased expression of CYP17A1 mRNAincreases expression 16375936
C045362 prochloraz prochloraz results in increased expression of CYP17A1 proteinincreases expression 16375936
D011374 Progesterone CYP17A1 protein affects the metabolism of Progesteroneaffects metabolic processing 16054388
16030167
D011374 Progesterone CYP17A1 protein binds to and affects the metabolism of Progesteroneaffects binding|affects metabolic processing 14522586
D011374 Progesterone CYP17A1 protein results in increased hydroxylation of Progesteroneincreases hydroxylation 15562394
D011374 Progesterone CYP17A1 protein affects the metabolism of Progesteroneaffects metabolic processing 15261307
D011374 Progesterone CYP17A1 protein results in increased hydroxylation of Progesteroneincreases hydroxylation 15640159
C031280 pyrazole pyrazole results in decreased expression of CYP17A1 mRNAdecreases expression 17945193
D019289 Pyruvic Acid Pyruvic Acid promotes the reaction [CTBP1 protein binds to CYP17A1 promoter]affects binding|increases reaction 18184656
D019289 Pyruvic Acid Pyruvic Acid promotes the reaction [CTBP2 protein binds to CYP17A1 promoter]affects binding|increases reaction 18184656
D019289 Pyruvic Acid Pyruvic Acid promotes the reaction [NR5A1 protein binds to CYP17A1 promoter]affects binding|increases reaction 18184656
D019289 Pyruvic Acid Pyruvic Acid results in increased expression of CYP17A1 mRNAincreases expression 18184656
D012176 Retinoids Retinoids results in increased expression of CYP17A1 mRNAincreases expression 15914525
C089730 rosiglitazone rosiglitazone results in decreased activity of CYP17A1 proteindecreases activity 15072549
D013110 Sphingosine Sphingosine results in increased expression of CYP17A1 mRNAincreases expression 15666826
C060506 sphingosine 1-phosphate sphingosine 1-phosphate results in increased expression of CYP17A1 mRNAincreases expression 15666826
D013739 Testosterone Testosterone results in decreased expression of CYP17A1 mRNAdecreases expression 15625562
D013739 Testosterone Testosterone results in decreased expression of CYP17A1 mRNAdecreases expression 15625562
D013739 Testosterone AMH protein inhibits the reaction [CYP17A1 protein affects the chemical synthesis of Testosterone]affects chemical synthesis|decreases reaction 14630719
D013739 Testosterone CYP17A1 protein affects the chemical synthesis of Testosteroneaffects chemical synthesis 15932923
D013739 Testosterone [bisphenol A results in decreased expression of CYP17A1 protein] which results in decreased abundance of Testosteronedecreases abundance|decreases expression 14605012
D013739 Testosterone [bisphenol A results in increased expression of CYP17A1 mRNA] which affects the abundance of Testosteroneaffects abundance|increases expression 18191889
D013739 Testosterone [prochloraz results in decreased activity of CYP17A1 protein] which results in decreased chemical synthesis of Testosteronedecreases activity|decreases chemical synthesis 17369198
17234647
D043343 Testosterone Propionate Testosterone Propionate results in decreased expression of CYP17A1 mRNAdecreases expression 15601916
C517826 tetrabrominated diphenyl ether 47 tetrabrominated diphenyl ether 47 analog results in decreased activity of CYP17A1 proteindecreases activity 16828825
D013749 Tetrachlorodibenzodioxin Gonadotropins, Equine inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of CYP17A1 mRNA]decreases expression|decreases reaction 19276399
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of CYP17A1 mRNAdecreases expression 17291543
19276399
16960034
19490992
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of CYP17A1 proteindecreases expression 17291543
19276399
D013752 Tetracycline Tetracycline results in decreased expression of CYP17A1 mRNAdecreases expression 16917069
D013755 Tetradecanoylphorbol Acetate Tetradecanoylphorbol Acetate inhibits the reaction [Forskolin results in increased expression of CYP17A1 protein]decreases reaction|increases expression 15666819
D013755 Tetradecanoylphorbol Acetate Tetradecanoylphorbol Acetate results in decreased expression of CYP17A1 proteindecreases expression 15666819
D013755 Tetradecanoylphorbol Acetate Tetradecanoylphorbol Acetate inhibits the reaction [Forskolin results in increased expression of CYP17A1 protein]decreases reaction|increases expression 15666819
D013755 Tetradecanoylphorbol Acetate Tetradecanoylphorbol Acetate results in decreased expression of CYP17A1 proteindecreases expression 15666819
D013764 Tetrahydronaphthalenes Tetrahydronaphthalenes results in decreased activity of CYP17A1 proteindecreases activity 15743198
C020809 tetrathiomolybdate tetrathiomolybdate results in increased expression of CYP17A1 mRNAincreases expression 16731777
C052342 topiramate topiramate results in decreased activity of CYP17A1 proteindecreases activity 15730543
D014212 Tretinoin Tretinoin results in increased expression of CYP17A1 mRNAincreases expression 16621909
D014212 Tretinoin Tretinoin results in decreased expression of CYP17A1 mRNAdecreases expression 14960491
D014260 Triclosan Triclosan results in decreased expression of CYP17A1 mRNAdecreases expression 19118620
C057693 troglitazone troglitazone results in decreased activity of CYP17A1 proteindecreases activity 15072549
D014635 Valproic Acid Valproic Acid results in decreased expression of CYP17A1 mRNAdecreases expression 19566492
D014635 Valproic Acid Valproic Acid results in increased expression of CYP17A1 mRNAincreases expression 14576182
D014635 Valproic Acid Valproic Acid results in increased expression of CYP17A1 proteinincreases expression 14576182
C025643 vinclozolin vinclozolin results in increased expression of CYP17A1 mRNAincreases expression 14967917
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Carbamazepine 17.588986270
MESH:D000014 Abnormalities, Drug-Induced methoxyacetic acid 17.5812805644 1761407 1761404 3652986 15959878
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 17.586195326
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 17.5815322242 14514962 11752688
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 17.588875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 3.1319490988
MESH:D000138 Acidosis Ammonium Chloride 2.6918287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.0517505938
MESH:D055371 Acute Lung Injury pirinixic acid 2.3118653653
MESH:D000230 Adenocarcinoma arsenic trioxide 9.9619825857 11798837
MESH:D000230 Adenocarcinoma Dimethylnitrosamine 9.9616033868
MESH:D000230 Adenocarcinoma Estradiol 9.9611473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 9.9614692618
MESH:D000230 Adenocarcinoma Genistein 9.9611473722
MESH:D000236 Adenoma Diethylnitrosamine 5.016695378 10737359
MESH:D000236 Adenoma Dimethylnitrosamine 5.0119555203
MESH:D018248 Adenoma, Liver Cell 3,4,5,3',4'-pentachlorobiphenyl 23.5116628245
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 23.5118056438 19061943 17162532 19052882 17620307 16434500
MESH:D018248 Adenoma, Liver Cell Phenobarbital 23.5117620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 23.5116434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 23.5116835633
OMIM:202110 ADRENAL HYPERPLASIA, CONGENITAL, DUE TO 17-ALPHA-HYDROXYLASE DEFICIENCY marker/mechanism
MESH:D000309 Adrenal Insufficiency Dehydroepiandrosterone 4.9017302879
MESH:D018246 Adrenocortical Adenoma Arsenic 4.3217306315
MESH:D000382 Agricultural Workers' Diseases Lindane 3.5212661182
MESH:D000437 Alcoholism topiramate 4.3117925516 18552399 19331489
MESH:D000505 Alopecia Isoflavones 7.1517569567
MESH:D000505 Alopecia Tretinoin 7.1515955085
MESH:D000544 Alzheimer Disease Androgens 6.9817182789 17917157
MESH:D000544 Alzheimer Disease Ozone 6.9815513908
MESH:D000544 Alzheimer Disease Plant Extracts 6.9816962711
MESH:D000544 Alzheimer Disease rosiglitazone 6.9819621015
MESH:D000550 Amblyopia Valproic Acid 4.3417688650
MESH:D000686 Amyloidosis Diethylstilbestrol 3.6415469931
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.1811748828
MESH:D000799 Angioedema Acetaminophen 2.9510982225
MESH:D000987 Antisocial Personality Disorder Testosterone 4.967506515
MESH:D001008 Anxiety Disorders etiracetam 10.8519265183
MESH:D001008 Anxiety Disorders Valproic Acid 10.8517497229
MESH:D001008 Anxiety Disorders vinclozolin 10.8519015723
MESH:D020261 Arsenic Poisoning Arsenic 2.5412569548 18414634 16835338 16251483
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 2.6111256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 8.7615885639
MESH:D001169 Arthritis, Experimental Plant Extracts 8.7614686799
MESH:D001169 Arthritis, Experimental Tretinoin 8.7616412693
MESH:D001172 Arthritis, Rheumatoid Ozone 3.6315570426
MESH:D001172 Arthritis, Rheumatoid Tretinoin 3.6316292516
MESH:D001249 Asthma Ozone 3.7116373670 17854713
MESH:D001249 Asthma Tretinoin 3.7116456186
MESH:D050197 Atherosclerosis Arsenic 7.9012928151 19371607
MESH:D050197 Atherosclerosis Cholesterol 7.9016632123
MESH:D050197 Atherosclerosis olive oil 7.9016216721
MESH:D001284 Atrophy fulvestrant 4.0111514358
MESH:D001321 Autistic Disorder Acetaminophen 2.7918445737
MESH:D001321 Autistic Disorder etiracetam 2.7919232924 19265183
MESH:D001321 Autistic Disorder pioglitazone 2.7917207275
MESH:D001321 Autistic Disorder tetrabrominated diphenyl ether 47 2.7919211157
MESH:D001321 Autistic Disorder Valproic Acid 2.7917157402 18985861 17688650 17507914 20603192 18316065 15238991 18558336 18775368 16609825 19460635 18177632 18396377 18940202 19232924
MESH:D001471 Barrett Esophagus Tretinoin 3.5616935849
MESH:D001714 Bipolar Disorder Carbamazepine 9.1317594078 20046352
MESH:D001714 Bipolar Disorder etiracetam 9.1319265183
MESH:D001714 Bipolar Disorder Valproic Acid 9.1320046352 17594078
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 15.4416206674
MESH:D001778 Blood Coagulation Disorders pirinixic acid 15.4419483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 15.4412125929
MESH:D001778 Blood Coagulation Disorders Tretinoin 15.4416206674 16197459
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 2.9015340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 5.9115746008
MESH:D001848 Bone Diseases, Developmental Valproic Acid 5.918888407
MESH:D001862 Bone Resorption bisphenol A 3.0711985600
MESH:D001919 Bradycardia antalarmin 5.4916710322
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 4.4417868700
MESH:D001930 Brain Injuries Pregnanolone 8.7615380490 15665606
MESH:D001930 Brain Injuries Progesterone 8.7615665606 15380490 15845082
MESH:D002545 Brain Ischemia Plant Extracts 3.8616041641
MESH:D001943 Breast Neoplasms Androgens 9.8617018787
MESH:D001943 Breast Neoplasms bisphenol A 9.8617123778
MESH:D001943 Breast Neoplasms Diethylnitrosamine 9.8617474063
MESH:D001943 Breast Neoplasms Diethylstilbestrol 9.8615324884 17129689
MESH:D001943 Breast Neoplasms Estradiol 9.8619861407 17018787 16675129 12948864 17261762 17289903 14630087 18497071
MESH:D001943 Breast Neoplasms Estrogens, Catechol 9.8617261777
MESH:D001943 Breast Neoplasms fulvestrant 9.8618984771
MESH:D001943 Breast Neoplasms Genistein 9.8617200150 16873071 16541309
MESH:D001943 Breast Neoplasms Lindane 9.8614688026
MESH:D001943 Breast Neoplasms Progesterone 9.8615562024 16175315 17614352
MESH:D001943 Breast Neoplasms Retinoids 9.8617368321 17491551 19340624
MESH:D001943 Breast Neoplasms Testosterone 9.8617261762
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 9.8620435547
MESH:D001943 Breast Neoplasms Tretinoin 9.8616166294 16443354 16873071
MESH:D016535 Bronchial Hyperreactivity Ozone 2.9614754758 16777450 19059883 18315731 17626835 15516495 18417511
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 3.7116813970
MESH:D002051 Burkitt Lymphoma arsenic trioxide 3.5111589617
MESH:D002057 Burns, Chemical Plant Extracts 4.449625245
MESH:D002100 Cachexia Ozone 3.8616183385
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 3.5816111702
MESH:D002277 Carcinoma Dimethylnitrosamine 5.9419555203
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 5.9416835633
MESH:D002280 Carcinoma, Basal Cell Arsenic 3.0215504454 17687452
MESH:D018236 Carcinoma, Embryonal Tretinoin 4.2616168501
MESH:D006528 Carcinoma, Hepatocellular marker/mechanism 15341023
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 25.7316705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 25.733084413
MESH:D006528 Carcinoma, Hepatocellular anthra(1,9-cd)pyrazol-6(2H)-one 25.7319418558
MESH:D006528 Carcinoma, Hepatocellular Arsenic 25.7316507464 17306315
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 25.7314691202 11135700 15073043 15553829 16217749
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 25.7319383236 16935385 19107877 16569478 17428255 20514400 18665156 16328049 10737359 19539802 19418558 16698587 19394651 16830150 20512989 18506893 20935162 19701751 20084675 18978308 18971187 19919837 21159647 16502159 16807293 17138121 16779866 20727157 11831363 16540662 18785209 18788625 20432363 17978847 18494052 19171122 20524982 19208518 18056438 16878318 16681979 17173139 18691550 10672840 17162532 20214788 20101231 17055752 19822196 16288022 19519916 3084413 20007298 18393292 17761372 18210153 19052882 3581430 19335982
MESH:D006528 Carcinoma, Hepatocellular Diethylstilbestrol 25.7316924424 15948411
MESH:D006528 Carcinoma, Hepatocellular Estradiol 25.7316924424
MESH:D006528 Carcinoma, Hepatocellular Estrogens 25.7315341023
MESH:D006528 Carcinoma, Hepatocellular Genistein 25.7316924424
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 25.7317173139 6705139 20007298 20935162 1701930
MESH:D006528 Carcinoma, Hepatocellular Plant Extracts 25.7318834353
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 25.731917145
MESH:D002278 Carcinoma in Situ bisphenol A 4.1117123778
MESH:D002291 Carcinoma, Papillary arsenic trioxide 3.9819014326
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 3.3312490120
MESH:D002294 Carcinoma, Squamous Cell Arsenic 7.8118922899 15504454 17687452
MESH:D002294 Carcinoma, Squamous Cell Dimethylnitrosamine 7.8116033868
MESH:D002294 Carcinoma, Squamous Cell Tetradecanoylphorbol Acetate 7.8118922899
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 7.8116096774 16051514
MESH:D002295 Carcinoma, Transitional Cell Arsenic 3.3018640142
MESH:D006332 Cardiomegaly Plant Extracts 5.0817645561
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 5.0816120746 18850075 18670907
MESH:D009202 Cardiomyopathies tetrathiomolybdate 4.7516242529
MESH:D002318 Cardiovascular Diseases Arsenic 12.0219152805 15738583 17938729
MESH:D002318 Cardiovascular Diseases Genistein 12.0216332659
MESH:D002318 Cardiovascular Diseases Isoflavones 12.0217689850
MESH:D002318 Cardiovascular Diseases olive oil 12.0216216721
MESH:D002340 Carotid Artery Diseases Arsenic 3.5418022660 16973168
MESH:D002386 Cataract Acetaminophen 5.2410977129
MESH:D002386 Cataract Tretinoin 5.2417460283
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 7.542727394 7505956 17174075 21159647
MESH:D002471 Cell Transformation, Neoplastic Estradiol 7.5418566989
MESH:D002471 Cell Transformation, Neoplastic monomethylarsonous acid 7.5419716837
MESH:D002493 Central Nervous System Diseases Phenobarbital 3.394080065
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 3.7116129372
MESH:D002659 Child Development Disorders, Pervasive Androstenedione 10.4821398041
MESH:D002659 Child Development Disorders, Pervasive Testosterone 10.4820678186
MESH:D002659 Child Development Disorders, Pervasive topiramate 10.4815650499
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 10.4820734317
MESH:D018281 Cholangiocarcinoma 3,4,5,3',4'-pentachlorobiphenyl 11.8116628245
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 11.8119052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 11.8116835633
MESH:D002779 Cholestasis Ethinyl Estradiol 5.4316919318 17333356 16105132 17110522 11677210 17681005 15861022
MESH:D002779 Cholestasis pirinixic acid 5.4319176532
MESH:D002822 Choriocarcinoma Tretinoin 4.2616461808
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 4.2012621046 15340226 15668235 8697196 16354765
MESH:D002972 Cleft Palate Tretinoin 4.209407595
MESH:D003092 Colitis Tretinoin 2.8617035595
MESH:D003110 Colonic Neoplasms Genistein 2.1117182828
MESH:D015179 Colorectal Neoplasms arsenic trioxide 2.5720501625
MESH:D015179 Colorectal Neoplasms Isoflavones 2.5717116718
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 7.0117141729 14669216
MESH:D000013 Congenital Abnormalities Triclosan 7.0119283420
MESH:D023903 Coronary Restenosis arsenic trioxide 3.3512609071
MESH:D019465 Craniofacial Abnormalities 3,4,5,3',4'-pentachlorobiphenyl 7.2117686920
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 7.2110525206
MESH:D019465 Craniofacial Abnormalities Carbamazepine 7.219014606
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 7.2110048152 20055451 15322242
MESH:D019465 Craniofacial Abnormalities Tretinoin 7.219125849 17551590 9664655 10589399 8800419 16925845 14991402 9142499 9224671 9211117
MESH:D019465 Craniofacial Abnormalities Valproic Acid 7.218888407 17688650 16575769
MESH:D016638 Critical Illness Androgens 10.7816670151
MESH:D016638 Critical Illness Estrogens 10.7816670151
MESH:D003456 Cryptorchidism Dibutyl Phthalate 14.5216037377
MESH:D003456 Cryptorchidism Diethylstilbestrol 14.5216002989 12952375
MESH:D003456 Cryptorchidism vinclozolin 14.5214966744
MESH:D003490 Cyanosis 2,4-dinitrotoluene 3.1618551238
MESH:D003550 Cystic Fibrosis pioglitazone 4.1619747007
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 3.2815213294
MESH:D003876 Dermatitis, Atopic pirinixic acid 1.9318249437
MESH:D003920 Diabetes Mellitus rosiglitazone 3.5417446233
MESH:D003922 Diabetes Mellitus, Type 1 Dehydroepiandrosterone 3.3416616286
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 15.9020387270
MESH:D003924 Diabetes Mellitus, Type 2 Genistein 15.9016647724
MESH:D003924 Diabetes Mellitus, Type 2 pioglitazone 15.9016023994 12642470
MESH:D003924 Diabetes Mellitus, Type 2 rosiglitazone 15.9012642470
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 15.9017107852
MESH:D003924 Diabetes Mellitus, Type 2 topiramate 15.9016979414
MESH:D003924 Diabetes Mellitus, Type 2 troglitazone 15.9016023994
MESH:D003925 Diabetic Angiopathies troglitazone 4.7812601628
MESH:D003928 Diabetic Nephropathies Estradiol 6.6619279558
MESH:D003928 Diabetic Nephropathies Plant Extracts 6.6619706694
MESH:D003929 Diabetic Neuropathies Pregnanolone 9.5917187935
MESH:D003929 Diabetic Neuropathies Progesterone 9.5917187935
OMIM:607208 DRAVET SYNDROME Carbamazepine 4.5911748493
MESH:D004342 Drug Hypersensitivity Carbamazepine 3.8020216337 15057820 16538176 16538175
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 27.4718551238 21346803
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 27.4716227642 10915739 11834606 19420014 19416960 2444490 18071297 15619225 11461765 12594235 14986274 10663392 12705907 12540782 15968718 14550746 11421492 11529661 17522070 19164858 16781746 19923254 14725611 17906064 16177239 11287661 12958197 18713872 16485898 11743745 16081117 12153990 19370779 19739265 17562736 11739529 16109766 19085960 12392966 10774834 16393943
MESH:D056486 Drug-Induced Liver Injury Carbamazepine 27.4717465707
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 27.4719107877
MESH:D056486 Drug-Induced Liver Injury Dimethylnitrosamine 27.478172417
MESH:D056486 Drug-Induced Liver Injury fumonisin B1 27.4716221962
MESH:D056486 Drug-Induced Liver Injury Ketoconazole 27.4718289764
MESH:D056486 Drug-Induced Liver Injury pyrazole 27.4712499123
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 27.4720420201
MESH:D056486 Drug-Induced Liver Injury Tetracycline 27.4717522070
MESH:D056486 Drug-Induced Liver Injury troglitazone 27.4714986274
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 27.471733752 19641884
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.2019426721
MESH:D004362 Drug Toxicity Carbamazepine 6.0920216337
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 6.0911462148
MESH:D004421 Dystonia Phenobarbital 7.711851702
MESH:D004421 Dystonia Valproic Acid 7.711851702
MESH:D004487 Edema perfluorooctanoic acid 16.9517259670 12083418
MESH:D004487 Edema pirinixic acid 16.9512083418
MESH:D004487 Edema Plant Extracts 16.9512787963
MESH:D004487 Edema rosiglitazone 16.9512083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 16.9512711302 11000095
MESH:D004487 Edema Tetradecanoylphorbol Acetate 16.9516716910 9599246 11698051 7812673 15177302 8273558 8113982
MESH:D004489 Edema, Cardiac 3,4,5,3',4'-pentachlorobiphenyl 15.9617686920
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 15.9615322242 16714409 18230668
MESH:D004489 Edema, Cardiac Tretinoin 15.9618230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Carbamazepine 10.6717654737
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 10.6712538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 10.6717692515
MESH:D004714 Endometrial Hyperplasia Diethylstilbestrol 8.9816402032
MESH:D004714 Endometrial Hyperplasia Genistein 8.9816402032
MESH:D016889 Endometrial Neoplasms Diethylstilbestrol 16.6415700306 16804899
MESH:D016889 Endometrial Neoplasms Estradiol 16.6418566989 11473722 19148513
MESH:D016889 Endometrial Neoplasms Estrogens, Catechol 16.6418566989
MESH:D016889 Endometrial Neoplasms Genistein 16.6411473722
MESH:D016889 Endometrial Neoplasms Tretinoin 16.6416569247
MESH:D004715 Endometriosis Progesterone 6.3416134523
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 6.3410568697 9294722
MESH:D004719 Endomyocardial Fibrosis Plant Extracts 4.7915268973
MESH:D004816 Epidermal Necrolysis, Toxic Carbamazepine 9.2919915237 16538176 20485159 16415921 18855540
MESH:D004816 Epidermal Necrolysis, Toxic lamotrigine 9.2920235791
MESH:D004831 Epilepsies, Myoclonic Carbamazepine 19.4217275665
MESH:D004831 Epilepsies, Myoclonic lamotrigine 19.4217275665
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 19.423659116
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 19.4217275665 3659116
MESH:D004828 Epilepsies, Partial Carbamazepine 22.2116628512 17116037 15008574
MESH:D004828 Epilepsies, Partial etiracetam 22.2119265183
MESH:D004828 Epilepsies, Partial lamotrigine 22.2117116037
MESH:D004828 Epilepsies, Partial Phenobarbital 22.213922381 11558140
MESH:D004828 Epilepsies, Partial Valproic Acid 22.2116628512 3922381
MESH:D004827 Epilepsy Carbamazepine 18.8418234410 7988514 17465707 17178248 19620853 19439326 19700373 821787 9014606 20417680
MESH:D004827 Epilepsy lamotrigine 18.8419668019
MESH:D004827 Epilepsy Phenobarbital 18.8420417680
MESH:D004827 Epilepsy Plant Extracts 18.8419700373 19439326
MESH:D004827 Epilepsy topiramate 18.8419148780
MESH:D004827 Epilepsy Valproic Acid 18.8418234410 20417680
MESH:D004832 Epilepsy, Absence etiracetam 10.7419265183
MESH:D004832 Epilepsy, Absence Phenobarbital 10.746401628
MESH:D004832 Epilepsy, Absence Valproic Acid 10.747562514 6254150 6426943
MESH:D017029 Epilepsy, Complex Partial Carbamazepine 14.487750514
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 14.487750514
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 14.487750514
MESH:D004833 Epilepsy, Temporal Lobe lamotrigine 11.9316499746
MESH:D004833 Epilepsy, Temporal Lobe topiramate 11.9316499746
MESH:D004830 Epilepsy, Tonic-Clonic Carbamazepine 18.3915276670 3659116
MESH:D004830 Epilepsy, Tonic-Clonic etiracetam 18.3919265183
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 18.393659116
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 18.393659116
MESH:C535500 Epileptic encephalopathy, Lennox-Gastaut type etiracetam 5.9419265183
MESH:D004916 Erythromelalgia Carbamazepine 4.8419549232
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 4.2216302075
MESH:D004938 Esophageal Neoplasms arsenic trioxide 3.6812903497
MESH:D004938 Esophageal Neoplasms Dimethylnitrosamine 3.6817016578
MESH:D005076 Exanthema Carbamazepine 4.5920485159
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 6.5111564622
MESH:D005124 Eye Abnormalities Tretinoin 6.5116938888 9664655
MESH:D015785 Eye Diseases, Hereditary Retinoids 5.1416968212
MESH:D005234 Fatty Liver arsenic trioxide 29.5115073043
MESH:D005234 Fatty Liver Diethylnitrosamine 29.5120387270 21071580
MESH:D005234 Fatty Liver Ethinyl Estradiol 29.5115345470
MESH:D005234 Fatty Liver pirinixic acid 29.5119236843 20131406
MESH:D005234 Fatty Liver Plant Extracts 29.5115975614
MESH:D005234 Fatty Liver rosiglitazone 29.5119196556
MESH:D005234 Fatty Liver Tetracycline 29.5119224547 16917069
MESH:D005234 Fatty Liver Valproic Acid 29.5119224547 14986274
MESH:D052776 Female Urogenital Diseases Diethylstilbestrol 3.0516002989 16611131 15751030 16513791 16534752
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 2.6011858732
MESH:D005315 Fetal Diseases Valproic Acid 3.9916575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 3.2918558336 8888407
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 5.8020067830
MESH:D005355 Fibrosis Tretinoin 5.8017994277
MESH:D005391 Firesetting Behavior Testosterone 4.967506515
MESH:D005532 Foot Deformities, Congenital methoxyacetic acid 4.883652986
MESH:D005534 Foot Diseases Arsenic 4.666392382
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 3.4216904648
MESH:D005756 Gastritis Acetaminophen 2.7916983495
MESH:D030342 Genetic Diseases, Inborn vinclozolin 4.0516973722
MESH:D005832 Genital Diseases, Male vinclozolin 4.4016417039
MESH:D005833 Genital Neoplasms, Female Diethylstilbestrol 4.0716452187
MESH:D005909 Glioblastoma Genistein 11.8216598420
MESH:D005909 Glioblastoma perfluorooctane sulfonic acid 11.8217162496
MESH:D005909 Glioblastoma Testosterone 11.8217162496
MESH:D005909 Glioblastoma Tretinoin 11.8217312396
MESH:D005923 Glomerulosclerosis, Focal Segmental pioglitazone 4.5116687628
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 3.7010696789
MESH:D006258 Head and Neck Neoplasms Retinoids 6.2117368321
MESH:D006258 Head and Neck Neoplasms Tretinoin 6.2116096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 4.2616084493
MESH:D006330 Heart Defects, Congenital 3,4,5,3',4'-pentachlorobiphenyl 8.0817686920 20471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 8.0810048152 11294989
MESH:D006330 Heart Defects, Congenital Tretinoin 8.089664655 14991402
MESH:D006333 Heart Failure pirinixic acid 5.2120558911
MESH:D006333 Heart Failure Plant Extracts 5.2118097624
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 2.5411000095
MESH:D006527 Hepatolenticular Degeneration tetrathiomolybdate 5.4217276780
MESH:D006529 Hepatomegaly fumonisin B1 18.2016221962
MESH:D006529 Hepatomegaly perfluorooctanoic acid 18.203609246
MESH:D006529 Hepatomegaly Phenobarbital 18.2016109766
MESH:D006529 Hepatomegaly pirinixic acid 18.2019772884 19176532 18467677 16221962
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 18.2015340226 16120746 12621046
MESH:D006558 Herpes Genitalis Estradiol 4.1415709030
MESH:D006561 Herpes Simplex Plant Extracts 3.7610715843
MESH:D006628 Hirsutism Androgens 10.6817019078 16914592
MESH:D006628 Hirsutism Testosterone 10.6817019078
MESH:D015658 HIV Infections Plant Extracts 3.1512878215
MESH:D019584 Hot Flashes Estradiol 12.1617088409
MESH:D019584 Hot Flashes Isoflavones 12.1614716179 17290160
MESH:D019584 Hot Flashes Plant Extracts 12.1617454163 16566672 14716179
MESH:D006849 Hydrocephalus Valproic Acid 3.9917688650
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.1516354765 16959395 15340226 8697196 18606429
MESH:D006930 Hyperalgesia Acetaminophen 12.7816870215
MESH:D006930 Hyperalgesia perfluorooctanoic acid 12.7812083418
MESH:D006930 Hyperalgesia rosiglitazone 12.7812083418
MESH:D006930 Hyperalgesia Tretinoin 12.7816870215
MESH:D017588 Hyperandrogenism Androgens 14.8717019078
MESH:D017588 Hyperandrogenism Flutamide 14.8715356085
MESH:D017588 Hyperandrogenism Testosterone 14.8717019078
MESH:D006937 Hypercholesterolemia Cholesterol 4.1816933029
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 3.7116778211
MESH:D006943 Hyperglycemia pirinixic acid 2.4120558911
MESH:D020138 Hyperhomocysteinemia Carbamazepine 7.3010459572
MESH:D020138 Hyperhomocysteinemia Plant Extracts 7.3016484555
MESH:D017488 Hyperkeratosis, Epidermolytic Arsenic 3.6717050553
MESH:D006949 Hyperlipidemias Plant Extracts 3.6615268973 15975614
MESH:D006965 Hyperplasia Carbamazepine 8.4618773962
MESH:D006965 Hyperplasia Diethylstilbestrol 8.4612960047 14722030
MESH:D006968 Hypersensitivity, Delayed Corn Oil 4.9211484837
MESH:D006973 Hypertension Arsenic 3.7911953799 16076760 9931084
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 3.7918850075 18670907
MESH:D006987 Hypesthesia Arsenic 4.6616093927
MESH:D007006 Hypogonadism Testosterone 3.9112002444
MESH:D007018 Hypopituitarism Testosterone 5.3117426086
MESH:D007021 Hypospadias Diethylstilbestrol 8.3916002989
MESH:D007021 Hypospadias Ethinyl Estradiol 8.3916569931 16945680
MESH:D007174 Impulse Control Disorders Testosterone 4.967506515
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 3.5415869954
MESH:D007246 Infertility Diethylstilbestrol 3.5215036965
MESH:D007247 Infertility, Female Ethinyl Estradiol 2.6512013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 14.3517937319
MESH:D007248 Infertility, Male fulvestrant 14.3511514358
MESH:D007248 Infertility, Male Methoxychlor 14.3511955947 16467254
MESH:D007248 Infertility, Male Triclosan 14.3520821571
MESH:D007248 Infertility, Male vinclozolin 14.3516467254
MESH:D007249 Inflammation Diethylnitrosamine 22.3118785209
MESH:D007249 Inflammation perfluorooctanoic acid 22.3112083418
MESH:D007249 Inflammation pioglitazone 22.3116908763
MESH:D007249 Inflammation Plant Extracts 22.3115997105 12787963 16366677 19332304
MESH:D007249 Inflammation Progesterone 22.3115869954
MESH:D007249 Inflammation rosiglitazone 22.3112083418
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 22.3112878042 12200463
MESH:D007249 Inflammation Tetradecanoylphorbol Acetate 22.3111698051 8273558 15177302 7812673 7562506
MESH:D007249 Inflammation Triclosan 22.319584910 20507366
MESH:D007333 Insulin Resistance bisphenol A 12.4316393666
MESH:D007333 Insulin Resistance Estradiol 12.4316393666 16627594
MESH:D007333 Insulin Resistance pirinixic acid 12.4316306350
MESH:D007333 Insulin Resistance rosiglitazone 12.4316306350
MESH:D007410 Intestinal Diseases Tretinoin 2.9217994277
MESH:D007414 Intestinal Neoplasms Plant Extracts 3.8412351151 12584176 12628509
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 7.2716580747
MESH:D007569 Jaw Abnormalities Tretinoin 7.2715992940 17551590
MESH:D007642 Keratosis Arsenic 4.1112749816 16930632
MESH:D007674 Kidney Diseases Acetaminophen 3.9712587719 15629191
MESH:D007674 Kidney Diseases Estradiol 3.9715618244
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 8.2116705839
MESH:D007680 Kidney Neoplasms Diethylstilbestrol 8.2115003126 16762066 14681315
MESH:D007680 Kidney Neoplasms Estradiol 8.2115610895
MESH:D007859 Learning Disorders Cholesterol 7.2817134702
MESH:D007859 Learning Disorders Diethylstilbestrol 7.2817184923
MESH:D016773 Leishmaniasis, Cutaneous Ketoconazole 3.968889330 2166429 19744259 1311351
MESH:D007898 Leishmaniasis, Visceral Ketoconazole 3.8511332679
MESH:D007938 Leukemia arsenic trioxide 7.4015070760
MESH:D007938 Leukemia Genistein 7.4017468513 18980019
MESH:D007938 Leukemia Tretinoin 7.4017143497
MESH:D004915 Leukemia, Erythroblastic, Acute troglitazone 5.2516085563
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 3.0017077332 12560223
MESH:D007948 Leukemia, Monocytic, Acute anthra(1,9-cd)pyrazol-6(2H)-one 14.6416972261
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 14.6416972261
MESH:D007948 Leukemia, Monocytic, Acute PD 98059 14.6416972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 2.7414633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 11.6019077051
MESH:D007951 Leukemia, Myeloid Retinoids 11.6016482212
MESH:D007951 Leukemia, Myeloid Tretinoin 11.6016482212 16932348 19285840
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 4.5919850784 16467208 16968895 20471514 17050201
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 4.5919850784 17596541 16294345
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 4.5917596541 16294345
MESH:D015473 Leukemia, Promyelocytic, Acute Arsenic 9.0717339181
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 9.0716331271 17869043 11468182 16891316 9834237 19225113 16330433 17217047 16112521 11161223 15748426 15622746 15336539 16966277 12712474 12018890 19035177 15213294 19642359 12679006 17107899 16823087 17712046 17649720 19075265
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 9.0716331271 17361223 17506722 17339181 19029980 16823087 17301526 17294898 16766008 16788101 12679006 19642359 16935935 17649720 19225113 17712046 17368321 17107899 15748426 16891316 19075265 9834237 17217047 16140955 19035177
MESH:D015458 Leukemia, T-Cell arsenic trioxide 3.5116882451
MESH:D007984 Leydig Cell Tumor perfluorooctanoic acid 10.038812269
MESH:D007984 Leydig Cell Tumor vinclozolin 10.0316417039
MESH:D017880 Limb Deformities, Congenital methoxyacetic acid 6.3912805644 15959878
MESH:D017880 Limb Deformities, Congenital Tretinoin 6.399224671
MESH:D008064 Lipidoses Ketoconazole 3.9017567588
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 7.8318522880 18665156 19638242 20032147 18407596
MESH:D008103 Liver Cirrhosis Phenobarbital 7.8321047994
MESH:D008103 Liver Cirrhosis Plant Extracts 7.8317157831
MESH:D008106 Liver Cirrhosis, Experimental marker/mechanism 17072980
MESH:D008106 Liver Cirrhosis, Experimental Dimethylnitrosamine 11.8016544323 18637143 15339415 17534399 18095165 17198567 15298665 16169303 18672772 14726149 15942678 17201889 12918455 18567088 17348192 15504291 17432682 18239293 15842777 18629640 17196135 15798949 16270385 15793283 18364076 16627068 15369754 15744066 15864749 15383259 18371158 15577212 15492853 12925901 17719030 17203207 17724770 15723089 15099470 17881167 15086199 16570917 14709902 16603200 15366600 15138612 15479170 15161499 15571005 14659978 15733078 15591649 17465448 15081153 15067225 17640959 18237412 18210741 17666798 16042886 17036385 15763062 14568256 16009107 14643895
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 11.8014659978 14716833
MESH:D008106 Liver Cirrhosis, Experimental Genistein 11.8017823541
MESH:D008106 Liver Cirrhosis, Experimental pioglitazone 11.8015052691 16484506
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 11.8015474484
MESH:D008106 Liver Cirrhosis, Experimental Plant Extracts 11.8015479170
MESH:D008106 Liver Cirrhosis, Experimental rosiglitazone 11.8017347453 15980055
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 11.8012878042
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 11.8018397230 16248980
MESH:D008107 Liver Diseases Acetaminophen 11.4119014921 16610002 12969438 16611625 19460945 19784758 11587558 12587719
MESH:D008107 Liver Diseases Arsenic 11.4111134558
MESH:D008107 Liver Diseases Diethylnitrosamine 11.4117034775
MESH:D008107 Liver Diseases Lindane 11.411715830
MESH:D008107 Liver Diseases Phenobarbital 11.4119363144
MESH:D008107 Liver Diseases Plant Extracts 11.4117034775
MESH:D017114 Liver Failure, Acute Acetaminophen 7.0817185352 16871587
MESH:D017114 Liver Failure, Acute Dimethylnitrosamine 7.0817457977
MESH:D008113 Liver Neoplasms Arsenic 31.4516368122
MESH:D008113 Liver Neoplasms arsenic trioxide 31.4514682389
MESH:D008113 Liver Neoplasms Clofibric Acid 31.4517602206
MESH:D008113 Liver Neoplasms Dehydroepiandrosterone 31.4518709148
MESH:D008113 Liver Neoplasms Diethylnitrosamine 31.4520452335 12112319 19427195 20583210 16942905 18977376 19833225 19499222 21047994 18648771 18644402 15175105 19812893 19254457 18754104 19690152 9163691 19996281 20434301 19294768 19850985 20101389 19256749 19638242 19551842 12771043 2422723 2862719 19090486 21278145 21167192 19255062 19073162 19426721 10737359 20137499 20492335 15885732 20405173 20501860 19642983 18978307 20118626 21071580
MESH:D008113 Liver Neoplasms Diethylstilbestrol 31.4515890375 16712894
MESH:D008113 Liver Neoplasms Dimethylnitrosamine 31.4515890375 3113478
MESH:D008113 Liver Neoplasms perfluorooctanoic acid 31.4514757943 18709148
MESH:D008113 Liver Neoplasms Phenobarbital 31.458742319 19812893 15975961 21047994 19482888 19073162
MESH:D008113 Liver Neoplasms pirinixic acid 31.4515890375 20007298 16377806
MESH:D008113 Liver Neoplasms Plant Extracts 31.4519168119
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 31.4516984957
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 15.4220377131
MESH:D008114 Liver Neoplasms, Experimental Dehydroepiandrosterone 15.428603461
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 15.4218775883 3124819 19519916 18544905 9362446 18079962 19009564 18093689 16267830 19126423 16842330 21159647 18282651 17174075 19539802 17942915 17854601 2563599 18308698 18253720 18164116 19004024
MESH:D008114 Liver Neoplasms, Experimental Dimethylnitrosamine 15.4215603536 6150874 1848544
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 15.421399818 18308698 17172636 6150874 2563599
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 15.4212151625
MESH:D008133 Long QT Syndrome arsenic trioxide 2.6515213294
MESH:D008171 Lung Diseases Ozone 2.748266340 19066396
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 3.3717228818
MESH:D055370 Lung Injury Ozone 3.0120417186
MESH:D008175 Lung Neoplasms Arsenic 9.6217306315 17976673 19168569
MESH:D008175 Lung Neoplasms arsenic trioxide 9.6211798837 19825857
MESH:D008175 Lung Neoplasms Diethylnitrosamine 9.6220970405 21163286 6695378 20512841
MESH:D008175 Lung Neoplasms Dimethylnitrosamine 9.6216061637 11884234 19555203
MESH:D008175 Lung Neoplasms Ozone 9.627614698 8597069
MESH:D008175 Lung Neoplasms Plant Extracts 9.6220869020
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 9.6211884234 19555203
MESH:D008175 Lung Neoplasms Tetradecanoylphorbol Acetate 9.6211807781
MESH:D008180 Lupus Erythematosus, Systemic Carbamazepine 3.2416628512
MESH:D008181 Lupus Nephritis Diethylstilbestrol 4.2715166399
MESH:D008223 Lymphoma Diethylstilbestrol 2.8115700306
MESH:D052801 Male Urogenital Diseases Diethylstilbestrol 4.6216002989
MESH:D008325 Mammary Neoplasms, Experimental Dehydroepiandrosterone 18.9416457693
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 18.9416891317 11807958 17203775 11408345
MESH:D008325 Mammary Neoplasms, Experimental Genistein 18.9414578162 12929590
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 18.9417203775 11408345
MESH:D008325 Mammary Neoplasms, Experimental rosiglitazone 18.9416827153
MESH:D008325 Mammary Neoplasms, Experimental Tetradecanoylphorbol Acetate 18.948985016
MESH:D008325 Mammary Neoplasms, Experimental Triclosan 18.9415358634
MESH:D020149 Manganese Poisoning Estradiol 3.5919453300
MESH:D008415 Mastocytosis Retinoids 5.7116953078
MESH:D008527 Medulloblastoma Tretinoin 2.3417453147
MESH:D008545 Melanoma Tretinoin 1.8116752155
MESH:D008546 Melanoma, Experimental Acetaminophen 2.7119513568
MESH:D008591 Meningomyelocele Tretinoin 3.5616940565
MESH:D008607 Mental Retardation Carbamazepine 3.349014606
MESH:D024821 Metabolic Syndrome X rosiglitazone 3.6317261469
MESH:D008679 Metaplasia Ozone 4.2110496685
MESH:D008881 Migraine Disorders topiramate 5.8118765137 18803445 16942474 18759728
MESH:D008881 Migraine Disorders Valproic Acid 5.8118765137 18803445
MESH:D019964 Mood Disorders etiracetam 5.4819265183
MESH:D009101 Multiple Myeloma arsenic trioxide 2.4515949261 19417148 14977855 19549372 11468182
MESH:D009135 Muscular Diseases pirinixic acid 2.6516239165
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 3.238888407
MESH:D009182 Mycosis Fungoides arsenic trioxide 3.7818349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 8.9116105982 16882451
MESH:D009190 Myelodysplastic Syndromes Tretinoin 8.9117596541
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 8.9117596541
MESH:D009203 Myocardial Infarction Genistein 4.1217141266
MESH:D009203 Myocardial Infarction pirinixic acid 4.1219151258
MESH:D017202 Myocardial Ischemia Arsenic 6.5715371236
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 6.5712213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 10.0516810080
MESH:D015428 Myocardial Reperfusion Injury Genistein 10.0517141266
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 10.0516411023
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 3.6017484760
MESH:D020190 Myoclonic Epilepsy, Juvenile etiracetam 5.1619265183
MESH:D009224 Myotonia Congenita Carbamazepine 4.5920399394
MESH:D009336 Necrosis 2,4-dinitrotoluene 2.9918551238
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 3.1216624393
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 2.143581430 9029167
MESH:D009369 Neoplasms Diethylstilbestrol 7.6015313581
MESH:D009369 Neoplasms Lindane 7.6012807735 16818664
MESH:D009369 Neoplasms pirinixic acid 7.6017405874
MESH:D009369 Neoplasms Tretinoin 7.6016594593 16946489
MESH:D009389 Neovascularization, Pathologic Estradiol 2.8617289903
MESH:D009395 Nephritis, Interstitial Tetracycline 3.909884423
MESH:D009421 Nervous System Malformations bisphenol A 33.4111399458 16427766
MESH:D009421 Nervous System Malformations Carbamazepine 33.4116990009
MESH:D009421 Nervous System Malformations Diethylstilbestrol 33.4111399458
MESH:D009421 Nervous System Malformations Estradiol 33.4116427766 11399458
MESH:D009421 Nervous System Malformations Genistein 33.4116427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 33.4114600291
MESH:D009421 Nervous System Malformations Tretinoin 33.419125849
MESH:D009436 Neural Tube Defects Arsenic 12.1216620997
MESH:D009436 Neural Tube Defects arsenic trioxide 12.1210525206
MESH:D009436 Neural Tube Defects Tretinoin 12.129142499
MESH:D009436 Neural Tube Defects Valproic Acid 12.128888407 16359493
MESH:D019954 Neurobehavioral Manifestations Plant Extracts 4.3217168769
MESH:D019636 Neurodegenerative Diseases Acetaminophen 5.7218514411
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 5.7220387270
MESH:D020078 Neurogenic Inflammation Arsenic 3.5617056641
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 4.2220387270
MESH:D052556 Niemann-Pick Disease, Type C Cholesterol 9.499802331 20557099
MESH:D052556 Niemann-Pick Disease, Type C perfluorooctanoic acid 9.499802331
MESH:D009765 Obesity pirinixic acid 3.6820558911
MESH:D009765 Obesity Plant Extracts 3.6819056576 20132043
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 2.6616049721 12819281
MESH:D010018 Osteomalacia Carbamazepine 9.1917016548
MESH:D010018 Osteomalacia Phenobarbital 9.1917016548
MESH:D010024 Osteoporosis Genistein 5.5519401787
MESH:D010024 Osteoporosis Isoflavones 5.5516562857
MESH:D015663 Osteoporosis, Postmenopausal Dehydroepiandrosterone 7.7216397352
MESH:D015663 Osteoporosis, Postmenopausal Genistein 7.7216169203
MESH:D010049 Ovarian Diseases bisphenol A 4.1111985600
MESH:D010051 Ovarian Neoplasms Arsenic 13.7817306315
MESH:D010051 Ovarian Neoplasms arsenic trioxide 13.7819769630 12452020 16624393
MESH:D010051 Ovarian Neoplasms Estradiol 13.7819401270
MESH:D010051 Ovarian Neoplasms Genistein 13.7819005980
MESH:D010051 Ovarian Neoplasms Progesterone 13.7816525653 17393432
MESH:D010051 Ovarian Neoplasms Tretinoin 13.7816936753
MESH:D010146 Pain Acetaminophen 7.1416870215
MESH:D010146 Pain Carbamazepine 7.1415215642
MESH:D010146 Pain Tretinoin 7.1416870215
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 11.7715580305
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 11.7716540662
MESH:D010190 Pancreatic Neoplasms Phenobarbital 11.7716965848
MESH:D010190 Pancreatic Neoplasms Tetradecanoylphorbol Acetate 11.7715976015
MESH:D010190 Pancreatic Neoplasms Tretinoin 11.7715976015
MESH:D016584 Panic Disorder Ethinyl Estradiol 8.7011578682
MESH:D016584 Panic Disorder etiracetam 8.7019265183
MESH:D010212 Papilloma Plant Extracts 6.9415173996 16517061
MESH:D010212 Papilloma Tetradecanoylphorbol Acetate 6.948330346 12065085 18404319 18922899
MESH:D010235 Paraganglioma arsenic trioxide 3.3419927285
MESH:D010267 Parapsoriasis Carbamazepine 4.8416538176
OMIM:167400 PAROXYSMAL EXTREME PAIN DISORDER Carbamazepine 5.0417145499 17679678
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 3.3512520081
MESH:D010391 Pemphigoid, Bullous Tetracycline 4.5411026799
MESH:D010523 Peripheral Nervous System Diseases Arsenic 3.3516093927
MESH:D016491 Peripheral Vascular Diseases Arsenic 4.116392382 15371236 16905509
MESH:D010538 Peritonitis Ozone 3.2816369182
MESH:D010900 Pituitary Diseases Diethylstilbestrol 4.2714722030
MESH:D010911 Pituitary Neoplasms Diethylstilbestrol 3.8115687265 16977796
MESH:D011014 Pneumonia Ozone 3.5218381685 18929643 18007984
MESH:D011085 Polycystic Ovary Syndrome Flutamide 4.2115356085
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 2.7218163543
MESH:D011230 Precancerous Conditions Corn Oil 11.1214668109
MESH:D011230 Precancerous Conditions Diethylnitrosamine 11.122563599
MESH:D011230 Precancerous Conditions Phenobarbital 11.122563599
MESH:D011248 Pregnancy Complications Carbamazepine 4.309014606
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 32.3510548101
MESH:D011297 Prenatal Exposure Delayed Effects Carbamazepine 32.359014606
MESH:D011297 Prenatal Exposure Delayed Effects Diethylstilbestrol 32.3517184923
MESH:D011297 Prenatal Exposure Delayed Effects perfluorooctanoic acid 32.3517132714
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 32.3511222880 11118676 11399792 11896295
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 32.3520603192
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 32.3518220299 18042343 19015723
MESH:D017096 Prion Diseases Tetracycline 4.5310903871
MESH:D011469 Prostatic Diseases vinclozolin 4.0518220299
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 13.4320887781
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 13.4320887781
MESH:D019048 Prostatic Intraepithelial Neoplasia Testosterone 13.4320887781
MESH:D011471 Prostatic Neoplasms marker/mechanism 15538743 16424004 16859836 16998812 17592021
MESH:D011471 Prostatic Neoplasms Androgens 5.4015389811 17909013 16998812
MESH:D011471 Prostatic Neoplasms Arsenic 5.4016140617
MESH:D011471 Prostatic Neoplasms arsenic trioxide 5.4019131511
MESH:D011471 Prostatic Neoplasms bisphenol A 5.4016740699
MESH:D011471 Prostatic Neoplasms Diethylstilbestrol 5.4017136230 15846301 15046698
MESH:D011471 Prostatic Neoplasms Estradiol 5.4016740699
MESH:D011471 Prostatic Neoplasms Estrogens, Catechol 5.4017261777
MESH:D011471 Prostatic Neoplasms Flutamide 5.403169114
MESH:D011471 Prostatic Neoplasms Genistein 5.4015256057 15378649 16925846
MESH:D011471 Prostatic Neoplasms Isoflavones 5.4017374662 17571952 16365062 17219775
MESH:D011471 Prostatic Neoplasms Ketoconazole 5.4017404083
MESH:D011471 Prostatic Neoplasms Lindane 5.4014688026 12661182
MESH:D011471 Prostatic Neoplasms Plant Extracts 5.4017804756 14666653
MESH:D011471 Prostatic Neoplasms Retinoids 5.4016166285 16724957
MESH:D011472 Prostatitis vinclozolin 4.0518629315
MESH:D011507 Proteinuria Arsenic 10.9421343184
MESH:D011507 Proteinuria pioglitazone 10.9416687628
MESH:D011507 Proteinuria Tretinoin 10.9416636307
MESH:D011537 Pruritus Ethinyl Estradiol 2.4515861022 16919318
MESH:D019310 Pseudolymphoma Carbamazepine 16.039591791 12752131
MESH:D019310 Pseudolymphoma Phenobarbital 16.0312752131
MESH:D019310 Pseudolymphoma Valproic Acid 16.0311422049 12752131
MESH:D011625 Pterygium Tretinoin 3.9116723453
MESH:D011629 Puberty, Precocious bisphenol A 3.9110548101
MESH:D011658 Pulmonary Fibrosis tetrathiomolybdate 5.4312624602 15541506
MESH:D011658 Pulmonary Fibrosis troglitazone 5.4318162602
MESH:D015427 Reperfusion Injury pirinixic acid 1.8819058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 2.9918990726
MESH:D012208 Rhabdomyosarcoma Tretinoin 8.1416283617 16116481
MESH:D012208 Rhabdomyosarcoma Valproic Acid 8.1419155313
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.4518045962
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 3.1216646077
MESH:D012559 Schizophrenia Valproic Acid 1.9219110320 15737665
MESH:D012640 Seizures 2,4-dinitrotoluene 21.7618551238
MESH:D012640 Seizures Carbamazepine 21.7616180713 16938433 9844417 15946322 16876388 19414003 9046859
MESH:D012640 Seizures etiracetam 21.7615946322 11738929
MESH:D012640 Seizures lamotrigine 21.7616499746 9844417
MESH:D012640 Seizures Lindane 21.767539098 12842176 15475178
MESH:D012640 Seizures Phenobarbital 21.763137016 16876388 4039156 11442880
MESH:D012640 Seizures topiramate 21.7616499746
MESH:D012640 Seizures Valproic Acid 21.7611738929 15475178 1511512 17978042 3137016 14763951 11044598 16876388
MESH:D003294 Seizures, Febrile Phenobarbital 3.946407741
OMIM:608579 SEVERE CUTANEOUS ADVERSE REACTION, SUSCEPTIBILITY TO lamotrigine 5.7320485159 19668019
MESH:D012735 Sexual Dysfunction, Physiological Testosterone 5.3116631401
MESH:D012871 Skin Diseases Arsenic 4.2719834688 15952646 6392382 17050553 16702368 18709164 16759981 17938729 17548696 16353154 17453740
MESH:D012871 Skin Diseases monomethylarsonous acid 4.2717431481
MESH:D012878 Skin Neoplasms Arsenic 15.8617050553 19538983 16251483 15504454 17029826 17976673
MESH:D012878 Skin Neoplasms Plant Extracts 15.8615173996 16517061
MESH:D012878 Skin Neoplasms Retinoids 15.8617538947
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 15.8616192470
MESH:D012878 Skin Neoplasms Tetradecanoylphorbol Acetate 15.8611807781 8330346 8985016 18404319 12065085
MESH:D012878 Skin Neoplasms Tretinoin 15.8616467112
MESH:D012893 Sleep Disorders Carbamazepine 4.2519414003
MESH:D013088 Spermatocele Diethylstilbestrol 8.7616709447 16002989
MESH:D013088 Spermatocele Ethinyl Estradiol 8.7616709447
MESH:D013119 Spinal Cord Injuries Progesterone 3.4115862959 16503802
MESH:D016135 Spinal Dysraphism Valproic Acid 3.0619490988
MESH:D013158 Splenic Diseases Dimethylnitrosamine 4.3812587719
MESH:D013226 Status Epilepticus Valproic Acid 3.6512833885
MESH:D013262 Stevens-Johnson Syndrome Carbamazepine 9.0718855540 15057820 16415921 16538176 20485159 19694795 19915237
MESH:D013262 Stevens-Johnson Syndrome lamotrigine 9.0720235791
MESH:D013274 Stomach Neoplasms arsenic trioxide 4.7717007042
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 4.7718456281
MESH:D013274 Stomach Neoplasms Dimethylnitrosamine 4.7716033868
MESH:D013274 Stomach Neoplasms Tretinoin 4.7717261132
MESH:D013274 Stomach Neoplasms troglitazone 4.7715930296
MESH:D013276 Stomach Ulcer olive oil 5.4912498302 16252198
MESH:D013276 Stomach Ulcer Plant Extracts 5.4917135157 12787963 15255614 18237397 18193104
MESH:D019966 Substance-Related Disorders bisphenol A 3.1216045194 16684133
MESH:D013576 Syndactyly methoxyacetic acid 4.791761404 1761407
MESH:D013705 Temporomandibular Joint Disorders Plant Extracts 4.5917997062
MESH:D013733 Testicular Diseases methoxyacetic acid 8.1018486176 6499806
MESH:D013733 Testicular Diseases pyrazole 8.106499806
MESH:D019851 Thrombophilia Ethinyl Estradiol 2.8011994571
MESH:D013927 Thrombosis Ethinyl Estradiol 2.4015669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 9.5412697716
MESH:D013959 Thyroid Diseases Triclosan 9.5419910387
MESH:D013964 Thyroid Neoplasms arsenic trioxide 15.0819014326
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 15.087505956
MESH:D013964 Thyroid Neoplasms Phenobarbital 15.081399818
MESH:D013964 Thyroid Neoplasms Retinoids 15.0816940797
MESH:D013964 Thyroid Neoplasms Tretinoin 15.0817045167 16026305
MESH:D013978 Tibial Fractures Estradiol 3.7919048282
MESH:D014062 Tongue Neoplasms Tretinoin 3.0116051514
MESH:D016171 Torsades de Pointes arsenic trioxide 3.0915213294
MESH:D005879 Tourette Syndrome etiracetam 5.5919265183
MESH:D014178 Translocation, Genetic Valproic Acid 4.3417262798
MESH:D014376 Tuberculosis Tretinoin 2.6116040207
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 3.643119515
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 11.0216049721
MESH:D001749 Urinary Bladder Neoplasms Arsenic 11.0219322015 15987713 11144890 18640142 17306315 19429237 17976673
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 11.0212845720 12973940 20435036 11780464
MESH:D001749 Urinary Bladder Neoplasms Diethylstilbestrol 11.0216452187 17306315 16712894
MESH:D001749 Urinary Bladder Neoplasms monomethylarsonous acid 11.0220375083
MESH:D014564 Urogenital Abnormalities Valproic Acid 3.788888407
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 3.4410091137
MESH:D014581 Urticaria Acetaminophen 2.1710982225
MESH:D002583 Uterine Cervical Neoplasms Diethylstilbestrol 6.9216175088
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 6.9216129372
MESH:D014591 Uterine Diseases bisphenol A 10.8514652134
MESH:D014591 Uterine Diseases Diethylstilbestrol 10.8514652134
MESH:D014594 Uterine Neoplasms Diethylstilbestrol 6.7015809267 16690809
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 6.7014692618
MESH:D014604 Uveal Neoplasms Tretinoin 3.7216752155
MESH:D014625 Vaginal Neoplasms Diethylstilbestrol 3.5816002989 16513791
MESH:D014652 Vascular Diseases Arsenic 3.8617056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 3.7012125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 2.7414671159 15869587
MESH:D018487 Ventricular Dysfunction, Left Plant Extracts 3.8918097624
MESH:D020257 Ventricular Remodeling Plant Extracts 4.4418097624
MESH:D014820 Vitiligo Tretinoin 3.2216761959
MESH:D014839 Vomiting etiracetam 5.3217157078
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 3.3515886252
MESH:D015431 Weight Loss tetrathiomolybdate 5.6512624602
MESH:D009396 Wilms Tumor Tretinoin 3.2016287080
MESH:D014947 Wounds and Injuries Estrogens 10.3611172683
MESH:D014947 Wounds and Injuries Plant Extracts 10.3619894650 20213670
MESH:D014947 Wounds and Injuries sphingosine 1-phosphate 10.3615541073
Pathway ID Pathway Name
REACT:13433 Biological oxidations
REACT:15314 Hormone biosynthesis
KEGG:01100 Metabolic pathways
REACT:22258 Metabolism of lipids and lipoproteins
KEGG:00140 Steroid hormone biosynthesis
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA27090
    • Releated gene ID Related gene Name
    PA27090CYP17A1
    Releated disease ID Related disease Name
    PA443560Breast Neoplasms
    Releated drug ID Related drug Name
    PA449512estrone
    PA451627testosterone
    PA451123progesterone
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB00157 - NADH Dietary supplement;Micronutrient
    DB00396 inhibitor Synovex S Contraceptives;Progestins
    Drugbank ID Action Drug Name Description
    DB00396 inhibitor Synovex S Contraceptives;Progestins
    DB01233 inhibitor Metoclopramide Antiemetics;Dopamine Antagonists;Prokinetic Agents
    DB01234 inhibitor Tresaderm Dermatologic Solution Anti-inflammatory Agents;Adrenergic Agents;Antiemetics;Antineoplastic Agents, Hormonal;Glucocorticoids
    DB01424 substrate Aminophenazone Analgesics;Pyrazolones
    DB02901 substrate Dihydrotestosterone Androgens;Steroidal
    DB04630 inducer Aldosterone
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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